Can tizanidine cause addiction. How does tizanidine affect the body. What are the dangers of abusing tizanidine. How to recognize signs of tizanidine abuse. What treatment options are available for tizanidine addiction.

Understanding Tizanidine: Uses and Mechanisms

Tizanidine, commonly known by its brand name Zanaflex, is a prescription medication primarily used as a muscle relaxant. It belongs to a class of drugs called alpha-2 adrenergic agonists and works by reducing muscle spasms and relieving pain associated with various conditions.

How does tizanidine work in the body. Tizanidine functions by slowing down brain and nervous system activity, which in turn allows muscle systems to relax. This mechanism of action makes it effective in treating muscle spasticity caused by conditions such as:

• Multiple sclerosis
• Spinal cord injuries
• Traumatic brain injuries
• Stroke

Additionally, tizanidine has shown efficacy in managing pain associated with:

• Lumbosacral neuralgia
• Chronic neck issues
• Musculoskeletal pain syndrome
• Migraine headaches

In some cases, healthcare providers may prescribe tizanidine off-label as an anticonvulsant to manage severe insomnia or migraines.

The Potential for Tizanidine Abuse and Addiction

Despite its therapeutic benefits, tizanidine carries a risk of abuse and addiction. This risk is often underestimated due to the misconception that non-narcotic medications are inherently safer or less addictive than narcotics.

Can tizanidine cause addiction. Yes, tizanidine can be addictive, especially when misused or taken for prolonged periods. A study conducted by the National Institutes of Health (NIH) reported that addiction to tizanidine typically occurs when the average dose exceeds 20 to 36 mg per day.

Why do people abuse tizanidine. Some individuals may initially misuse tizanidine to alleviate pain beyond their prescribed dosage. However, the euphoric effects experienced at higher doses can lead to psychological dependence and continued abuse.

Factors Contributing to Tizanidine Addiction

1. Prolonged use beyond the recommended duration
2. Taking higher doses than prescribed
3. Combining tizanidine with other substances for enhanced effects
4. Self-medicating for undiagnosed mental health issues
5. Genetic predisposition to substance abuse disorders

Recognizing the Signs of Tizanidine Abuse

Identifying tizanidine abuse early is crucial for preventing long-term health consequences and addiction. What are the signs of tizanidine abuse. Here are some indicators to watch for:

• Taking higher doses or using the medication more frequently than prescribed
• Seeking multiple prescriptions from different healthcare providers
• Experiencing withdrawal symptoms when not taking the medication
• Neglecting personal responsibilities due to drug use
• Continuing to use tizanidine despite negative consequences

Physical symptoms of tizanidine abuse may include:

• Extreme drowsiness or weakness
• Blurred vision
• Intense dry mouth
• Abnormal liver function
• Chronic runny nose or sore throat
• Urination problems
• Sporadic muscle movements

The Dangers of Tizanidine Abuse

Abusing tizanidine can lead to serious health risks and complications. What are the dangers of abusing tizanidine. Some of the most significant risks include:

Short-term Risks

• Severe drowsiness and impaired cognitive function
• Increased risk of accidents and injuries
• Potential for overdose, especially when combined with other substances
• Respiratory depression
• Cardiovascular issues, such as low blood pressure

Long-term Risks

• Development of physical and psychological dependence
• Liver damage due to prolonged abuse
• Chronic sleep disturbances
• Increased risk of mental health disorders
• Potential for severe withdrawal symptoms upon cessation

It’s important to note that the risks of tizanidine abuse are significantly amplified when the drug is combined with other substances, particularly central nervous system depressants like alcohol or opioids.

Tizanidine Withdrawal: Symptoms and Management

When a person who has been taking tizanidine regularly for an extended period stops using the medication abruptly, they may experience withdrawal symptoms. These symptoms occur because the body has become accustomed to the presence of the drug and needs time to readjust to functioning without it.

What are the common withdrawal symptoms of tizanidine. Withdrawal symptoms may include:

• Tachycardia (rapid heart rate)
• Hypertension (high blood pressure)
• Tremors
• Hypertonia (increased muscle tone)
• Severe anxiety
• Rebound muscle spasticity
• Insomnia
• Nausea and vomiting
• Sweating

How long do tizanidine withdrawal symptoms last. The duration and severity of withdrawal symptoms can vary depending on factors such as the length of use, dosage, and individual physiology. Typically, withdrawal symptoms may begin within 12-24 hours after the last dose and can persist for several days to weeks.

Managing Tizanidine Withdrawal

To minimize the risk and severity of withdrawal symptoms, healthcare providers often employ a gradual tapering strategy. This approach involves slowly reducing the dosage over time, allowing the body to adjust more comfortably.

What steps are involved in a tizanidine tapering plan.

1. Assessment: The healthcare provider evaluates the patient’s current dosage, duration of use, and overall health status.
2. Customized plan: A personalized tapering schedule is developed, typically reducing the dosage by 10-25% every 1-2 weeks.
3. Monitoring: Regular check-ins to assess progress and adjust the plan as needed.
4. Supportive care: Additional treatments may be provided to manage specific withdrawal symptoms.
5. Counseling: Psychological support to address any underlying issues contributing to drug use.

It’s crucial to emphasize that any attempt to discontinue tizanidine should be done under medical supervision to ensure safety and minimize discomfort.

Treatment Options for Tizanidine Addiction

Overcoming tizanidine addiction often requires a comprehensive treatment approach that addresses both the physical dependence and underlying psychological factors contributing to substance abuse.

What treatment options are available for tizanidine addiction. Effective treatment typically involves a combination of the following approaches:

1. Medical Detoxification

Supervised detoxification is often the first step in treatment, allowing the body to safely eliminate tizanidine while managing withdrawal symptoms. This process may involve:

• Gradual tapering of tizanidine dosage
• Administration of supportive medications to manage specific symptoms
• Continuous monitoring of vital signs and overall health

2. Inpatient Rehabilitation

For individuals with severe addiction or those who require a structured environment, inpatient rehabilitation programs offer:

• 24/7 medical supervision
• Intensive therapy sessions
• Peer support groups
• Holistic treatments (e.g., nutrition counseling, exercise programs)

3. Outpatient Treatment

Outpatient programs provide flexibility for those with less severe addictions or as a step-down from inpatient care. These programs typically include:

• Regular therapy sessions
• Medication management
• Support group meetings
• Life skills training

4. Cognitive Behavioral Therapy (CBT)

CBT is a widely used therapeutic approach that helps individuals:

• Identify triggers for drug use
• Develop coping strategies
• Address underlying mental health issues
• Modify thought patterns and behaviors associated with addiction

5. Support Groups

Participation in support groups, such as Narcotics Anonymous or SMART Recovery, can provide:

• Peer support and understanding
• Accountability
• Opportunities to learn from others’ experiences
• Long-term recovery support

6. Dual Diagnosis Treatment

For individuals with co-occurring mental health disorders, integrated treatment addressing both addiction and mental health is crucial. This may involve:

• Psychiatric evaluation and medication management
• Specialized therapy for specific mental health conditions
• Holistic approaches to overall well-being

Preventing Tizanidine Abuse and Addiction

While treatment options are available for tizanidine addiction, prevention remains the best approach. How can tizanidine abuse be prevented. Here are some strategies to reduce the risk of developing an addiction:

For Patients:

• Follow prescribed dosages and schedules strictly
• Communicate openly with healthcare providers about pain management
• Explore non-pharmacological pain management techniques
• Be aware of potential interactions with other medications or substances
• Regularly reassess the need for continued tizanidine use with your healthcare provider

For Healthcare Providers:

• Conduct thorough patient assessments before prescribing tizanidine
• Educate patients about the risks of misuse and potential for addiction
• Monitor patients closely for signs of dependence or abuse
• Consider alternative treatments for patients at high risk of substance abuse
• Implement prescription drug monitoring programs

For Family and Friends:

• Be aware of the signs of tizanidine abuse and addiction
• Encourage open communication about medication use
• Offer support for exploring alternative pain management strategies
• Help create a supportive environment that promotes healthy coping mechanisms

By implementing these preventive measures and maintaining open communication between patients, healthcare providers, and support systems, the risk of tizanidine abuse and addiction can be significantly reduced.

The Future of Tizanidine Use and Abuse Prevention

As awareness of the potential for tizanidine abuse grows, researchers and healthcare professionals are exploring new approaches to maximize the therapeutic benefits of the medication while minimizing the risk of addiction.

What developments are on the horizon for safer tizanidine use. Some promising areas of research and development include:

1. Novel Drug Formulations

Researchers are investigating new formulations of tizanidine that may have lower abuse potential, such as:

• Extended-release versions that provide steady pain relief with less potential for misuse
• Transdermal patches that deliver consistent doses over time
• Abuse-deterrent formulations that make the drug more difficult to misuse

2. Personalized Medicine Approaches

Advances in genetic testing and pharmacogenomics may allow healthcare providers to:

• Identify patients at higher risk for addiction
• Tailor dosing regimens based on individual metabolic profiles
• Predict potential drug interactions more accurately

3. Integration of Technology in Monitoring

The use of digital health technologies could enhance the monitoring of tizanidine use and early detection of misuse through:

• Smart pill dispensers that track medication adherence
• Mobile apps for real-time symptom and side effect reporting
• Wearable devices that monitor physiological responses to the medication

4. Enhanced Education and Training

Improving education for both healthcare providers and patients is crucial. Future initiatives may focus on:

• Mandatory continuing education for prescribers on the latest pain management guidelines
• Comprehensive patient education programs on the risks and proper use of tizanidine
• Public awareness campaigns to reduce the stigma associated with seeking help for medication misuse

5. Alternative Pain Management Strategies

Research into non-pharmacological and alternative treatments for muscle spasticity and pain may lead to:

• Advanced physical therapy techniques
• Innovative neuromodulation therapies
• Integration of mind-body practices in standard treatment protocols

As these developments progress, the goal is to create a more balanced approach to tizanidine use that maximizes its therapeutic potential while minimizing the risk of abuse and addiction. This ongoing research and innovation underscore the importance of staying informed about the latest advancements in pain management and substance abuse prevention.

In conclusion, while tizanidine remains an important tool in managing muscle spasticity and certain types of pain, it’s crucial to approach its use with caution and awareness. By understanding the potential for abuse, recognizing the signs of addiction, and being proactive in prevention and treatment, we can work towards safer and more effective use of this medication. As research continues to evolve, it’s important for patients, healthcare providers, and the general public to stay informed and engaged in the ongoing dialogue about responsible pain management and substance use.

Tizanidine Profile: Abuse, Effects and Treatment

Like many other prescription FDA-approved medications, tizanidine can be addictive. Tizanidine is not a narcotic. The drug is considered to be a muscle relaxer that helps to reduce pain, but in a different way than a narcotic. Rather than binding to pain receptors in the central nervous system, tizanidine blocks pain involving the skeletal muscle areas. Because tizanidine is not a narcotic, there is a societal perception that it is not as dangerous or addictive as narcotics. Consequently, tizanidine abuse has become more socially acceptable.

Identifying Tizanidine

Tizanidine comes in the form of small white tablets, commonly imprinted with E34. The most common brand name is Zanaflex and it is most often prescribed to treat muscle spasms. When abused, the medication is taken more often and for a longer duration than medically recommended. Tizanidine is a generic prescription drug but is known by other brand names, including:

• Zanaflex
• Sirdalud
• Relentus
• Tizanadine (intentional misspelling)
• Xanaflex

What Does Tizanidine Do?

Tizanidine is an antispasmodic prescription drug prescribed to be taken orally at designated intervals of time. It is typically used to treat symptoms occurring as the result of multiple sclerosis, stroke, spinal and brain injury. The drug is a controlled, pain-relief medicine that must be prescribed by a doctor. A common question asked is, “Is Tizanidine a narcotic?” The answer is that it is not a narcotic because it is a muscle relaxer. Technically speaking, it is an alpha-2 adrenergic agonist used for treating:

• Muscle cramping
• Muscle spasms
• Extreme tightening of muscles

Traumatic injuries and some diseases may require the use of tizanidine including:

• Spine or central nervous system injuries
• Spastic diplegia
• Severe and persistent back pain
• Multiple sclerosis

Tizanidine is an FDA-approved muscle relaxer medication used to treat muscle spasticity caused by:

• Traumatic brain injury
• Multiple sclerosis
• Spinal cord injury

It can also be effectively used to manage pain associated with:

• Lumbosacral neuralgia
• Chronic neck issues
• Musculoskeletal pain syndrome
• Migraine headaches

Tizanidine is used in some cases as an anti-convulsant effective for the managing of migraine headaches and severe insomnia. Spasm and muscle tone are symptoms in those who have had a stroke, multiple sclerosis, brain or spinal injury. Tizanidine is effective for slowing down brain and nervous system action, allowing the muscle systems to relax. Muscle relaxers have a half-life of about 37 hours, and it takes 3-5 days for the drug to be completely eliminated from your body.

Addiction to Tizanidine

A case study conducted by NIH reported that addiction to tizanidine occurs when the average dose exceeds 20 to 36 mg. If you have been taking tizanidine regularly for a prolonged period of time, you will more than likely experience symptoms once you cease to take it.

Does Tizanidine Have Addictive Qualities?

Like many other similar drugs, tizanidine can be addictive. Sometimes addiction develops as the result of misuse; at other times, prolonged use may lead to addiction. Tizanidine affects the central nervous system, which leads to withdrawal symptoms when it is stopped immediately.

What Are the Dangers of Abusing Tizanidine

If you are taking tizanidine in high doses for a prolonged period (more than nine weeks), you may experience the following symptoms:

• Hypertension
• Tachycardia
• Spasticity

Those who abuse this drug typically mix it with other drugs, which can cause more complicated risks and side effects. Severe drowsiness, increased euphoria, confusion and/or other symptoms are common.

Doctors employ a gradual reduction plan for patients taking this drug to try to avoid withdrawal symptoms. The withdrawal symptoms experienced may include:

• Tachycardia
• Hypertension
• Tremor
• Hypertonia
• Severe anxiety

Tizanidine is a short-acting medication and its effects take 1-3 hours to activate.

Signs of Short-Term and Long-Term Abuse

Patients who abuse tizanidine may do so because they are experiencing pain and want to relieve their pain using the muscle relaxer. However, taking higher doses than what is prescribed often provides a euphoric feeling that can become addictive.

If you notice that a loved one is experiencing the following physical issues, they may be suffering from the potential side effects of tizanidine abuse or addiction:

• drowsiness or weakness;
• nervousness
• blurred vision
• flu-like symptoms
• intense dry mouth
• abnormal liver function
• chronic runny nose or sore throat
• urination problems
• sporadic muscle movements

The drug may impair thinking or reactions. The risks of poor judgment and falling asleep at the whee are high for those who drive while taking tizanidine. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

A short-term addiction to tizanidine can be tricky to identify: It does not manifest itself in the more obvious ways that a short-term addiction to narcotics would. The most dangerous part of tizanidine addiction are the risks associated with withdrawal when a long-term user stops taking the drug.

To prevent addiction, it is important that patients take the drug exactly as prescribed and stay in close communication with their healthcare provider.

Often patients are instructed to take tizanidine up to three times in one day if needed. Allow 6-8 hours to pass between doses.

Tizanidine may be taken with or without food, but it is important to take it the same way each time. Taking tizanidine with food sometimes and taking it without food other times can reduce the effectiveness of the medicine.

Follow your doctor’s instructions carefully and contact your doctor immediately if you notice any changes.

Treatment for Tizanidine Addiction

As with other drugs, treatment for tizanidine addiction will depend on the severity of the addiction. Withdrawal should be supervised by a doctor to minimize potentially dangerous withdrawal symptoms. A step-down regiment by which the dosage is gradually reduced over time is the best course for addressing dependency and addiction.

Tizanidine side effects are commonly present after the medication is abruptly stopped, which is why doctors will regulate the process. Most Tizanidine warnings are related to withdrawal of the medicine. Related warnings include:

• Hypotension
• Liver injury
• Increased drowsiness
• Hallucination
• Hypersensitivity reactions
• Withdrawal adverse reactions
• Nonclinical toxicology

Going off the drug on your own is dangerous and may lead to severe symptoms. The way in which other drugs interact with the drug can also increase the danger and complicate the treatment plan. Often, treatment for a tizanidine problem can be completed in an outpatient capacity. When an addiction is severe, inpatient treatment is the better choice.

Tizanidine: 7 things you should know

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Medically reviewed by Carmen Pope, BPharm. Last updated on April 4, 2023.

1. How it works

• Tizanidine may be used to treat spasticity associated with a brain or spinal injury.
• Tizanidine works by a central mechanism (this means it acts in the brain) but experts are not sure exactly how it works to reduce muscle tone and spasms, but suggest it may be due to tizanidine increasing presynaptic inhibition of the nerves that supply the muscles. Tizanidine works more on polysynaptic pathways rather than monosynaptic spinal reflexes. Tizanidine relaxes muscles by dampening down nerve impulses that are sent from spasming muscles along nerve fibers to the brain.
• Tizanidine belongs to the class of medicines known as central alpha-2-adrenergic agonists. It may also be called a centrally-acting muscle relaxant.

2. Upsides

• May be used to reduce muscle spasms that are associated with cerebral (brain) or spinal injury.
• May be used alone or together with other treatments for muscle spasms, such as baclofen.
• Effective at relaxing muscles (reduces muscle spasms).
• No direct effects on skeletal muscle fibers.
• May improve pain associated with muscle spasms.
• May be used on an as-needed basis.
• Despite being structurally related to clonidine, tizanidine has only 1/10th to 1/50th of clonidine’s antihypertensive effect which means it is less likely to lower blood pressure than clonidine.
• Tizanidine is usually started as a dosage of 2mg to 4mg to minimize the risk of side effects; however, dosages less than 8mg have been shown to be ineffective in clinical trials. The dosage should be increased by 2-4mg daily for 2 to 4 weeks until the best effects are seen.
• No dosage adjustments are needed for liver disease.
• Generic tizanidine is available.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

• Low blood pressure, drowsiness, dizziness, energy loss, and a dry mouth.
• Has been associated with hallucinations and rarely psychosis in approximately 3% of people.
• The dosage of tizanidine needs to be individualized according to a person’s requirements and response.
• May not be suitable for people that rely on spasticity to sustain their posture and balance.
• May cause a drop in blood pressure when going from a sitting or lying down position to standing. This may increase the risk of falls.
• May affect a person’s ability to drive or operate machinery. Alcohol should be avoided.
• May cause withdrawal symptoms such as high blood pressure and a fast heartbeat if stopped abruptly after regular extended dosing (decrease dose slowly under a doctor’s advice). Withdraw tizanidine slowly. Decrease by about 2mg to 4mg per day.
• Seniors may be more susceptible to the side effects of tizanidine.
• Tizanidine may cause allergic reactions in some people, such as anaphylaxis and urticaria.
• May interact with several other drugs including those metabolized by hepatic enzymes CYP1A2 (such as fluvoxamine, ciprofloxacin, and some antiarrhythmics), and oral contraceptives. Alcohol increases the peak concentration of tizanidine and also the likelihood of side effects.
• Liver enzymes (specifically aminotransferase) should be monitored when starting treatment, when clinically indicated, and for at least one month after the maximum dosage is achieved.
• The different dosage forms of tizanidine (for example, the tablets vs capsules) and modification of the administration of tizanidine (for example swallowing the capsules whole vs opening them up and sprinkling them on applesauce) may cause clinically important differences in effect, such as more side effects or more rapid onset of activity.
• Needs to be given every 6 to 8 hours. The maximum single dose is 16mg and the maximum total daily dose is 36mg in 24 hours.
• The safety and effectiveness of tizanidine has not been established for people aged under 18 years.
• Lower total daily dosages may be necessary with kidney disease. Increase individual dosages if higher dosages are needed rather than increasing dosage frequency.

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be taken on an as needed basis. Monitoring of liver enzymes is required.

5.

Tips

• Capsules may be opened and the contents sprinkled on food.
• Taking with food increases absorption by 20% but slows the time for effect. Can be taken with or without food, but should be dosed consistently (either with or without food).
• Tizanidine is relatively short-acting; therefore it should be taken at times when relief of spasticity is the most important (such as before activities of daily living).
• Take tizanidine exactly as directed. Do not increase the dosage without your doctor’s advice. Tizanidine tablets and capsules are not directly interchangeable; a dosage adjustment may be necessary (talk with your doctor).
• Be careful when going from sitting or lying down position to standing as tizanidine may increase your risk of falls. Remove any fall hazards (such as loose rugs) from your home.
• Seek immediate medical advice if you experience any worrying side effects including hallucinations, fainting, sleepiness, or allergic-type reactions.
• Do not stop taking tizanidine suddenly without your doctor’s advice as high blood pressure and a fast heartbeat may result.
• Effects are dose-related (the bigger the dose, the stronger the effect, but the more noticeable any side effects are).
• Tizanidine can make you sleepy. The risk is greater if you also take other drugs, such as benzodiazepines, or sleeping pills. Do not drink any alcohol while taking tizanidine.
• Do not take any other medication, including medicines brought over-the-counter, in addition to tizanidine, without checking with your doctor or pharmacist to make sure they are compatible.

6. Response and effectiveness

• The effects of tizanidine peak within 1-2 hours and start to wear off within 3 to 6 hours. Because of this short duration of effect, tizanidine may be dosed on an “as needed” basis during times when muscle spasms are at their most severe.

7. Interactions

Medicines that interact with tizanidine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with tizanidine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with tizanidine include:

• acyclovir
• amiodarone
• anti-anxiety medications
• anticonvulsants
• antidepressants, such as amitriptyline, imipramine, nortriptyline
• antihistamines that cause sedation, such as diphenhydramine
• azelastine
• chlormethiazole
• ciprofloxacin
• dronedarone
• duloxetine
• fluvoxamine
• HIV medications such as saquinavir
• medications that lower blood pressure, such as ACE inhibitors (eg, enalapril), barbiturates, beta-blockers (such as atenolol), or calcium channel antagonists (such as diltiazem)
• medicines that inhibit CYP1A2 enzymes such as cimetidine or rifampin
• metoclopramide
• opioid analgesics such as oxycodone and morphine
• other muscle relaxants such as methocarbamol
• pimozide
• sleeping pills, such as zolpidem
• some chemotherapy treatments
• some medications used to treat mental illness, such as clozapine and thioridazine
• smoked tobacco
• treatments for erectile dysfunction, such as sildenafil or tadalafil
• topiramate
• zolpidem.

Alcohol may worsen the side effects of tizanidine such as drowsiness and dizziness.

Note that this list is not all-inclusive and includes only common medications that may interact with tizanidine. You should refer to the prescribing information for tizanidine for a complete list of interactions.

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References

• Tizanidine. Revised 03/2023. NorthStar Rx LLC. https://www.drugs.com/pro/tizanidine.html

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tizanidine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Admission Campaign – 2023

On our website in the section Home / Applicants / Applicants (specialist / bachelor / master) there is a video that details the rules for admission to Ryazan State Medical University.

06/13/2023

ALL-RUSSIAN EDUCATIONAL AND LEGAL INTENSIVE FOR STUDENTS IN MEDICINE AND PHARMACY
Ryazan State Medical University is hosting the All-Russian Educational and Legal Intensive for students of medicine and pharmacy, dedicated to the issues of medical education and healthcare, which will be held on June 15-17, 2023 at the address: Ryazan, st. Shevchenko, 34, building 2.

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06/13/2023

Competition for a university grant
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In the Olympiad in Surgical Dentistry and Maxillofacial Surgery, our students showed excellent results and deservedly won not only in the individual, but also in the team competition

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Rector spoke at the regional political council
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RyazGMU student works as a minister
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Commonwealth of graduates of the Ryazan State Medical University
Today we are publishing the history of a medical family, which was sent to us by Irina Alexandrovna Ovchinnikova, a graduate of the Faculty of Medicine in 2004.

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22.02.2023

TRAINING UNDER THE PROGRAM “NURSING IN PEDIATRICS” IS COMPLETED
On February 16, the 144-hour advanced training program “Nursing in Pediatrics” ended. During the training, nurses in the Ryazan region improved their knowledge and skills in nursing care for a healthy and sick child with infectious and somatic pathology, prevention of somatic and infectious pathology in childhood in accordance with the regulatory framework, professional standards and clinical recommendations.

02/16/2023

WetLab

02/14/2023

BASIC EMERGENCY FIRST AID COURSE

02/14/2023

COURSE “METHODS OF NON-TEST PSYCHODIAGNOSIS OF PERSONALITY”

27.09.2022

Russian as a foreign language (speech practice course)

FDPO

06/09/2023

Conference of Psychologists

We invite you to take part in the student scientific and practical conference “Formation of professional research competence of future clinical psychologists”

06/02/2023

I Congress of Therapists of the Central Federal District
On June 8-9, Ryazan State Medical University will host a forum aimed at practical healthcare professionals. The organizers are RNMOT, the Ministry of Health of the Ryazan Region and the Ryazan State Medical University.

06/02/2023

In June, the second cycle of training “Fundamentals of Kinesiology Taping” starts
The cycle is intended for everyone, regardless of the presence or absence of a medical education. Listeners have the opportunity to get or improve the skill of using elastic bands, to learn everything or almost everything about teips!

29.05.2023

Physical and Rehabilitation Medicine in Pediatrics
On June 3, 2023, the University will host the Interregional Scientific and Practical Conference “Physical and Rehabilitation Medicine in Pediatrics”. Beginning at 10.00 in the hall of the Academic Council, at the address: Ryazan, st. Vysokovoltnaya, d. 7, bldg. 1, 4th floor.

05/25/2023

Mental health service: achievements and prospects
We invite you to take part in the IX Interregional Scientific and Practical Conference “Mental Health Service: Achievements and Prospects. Dedicated to the 135th anniversary of the Ryazan Regional Clinical Psychiatric Hospital. N.N. Bazhenov”, which will be held on June 2, 2023 on the basis of the Ryazan Regional Clinical Psychiatric Hospital. Bazhenova N.N.

05/22/2023

WE INVITE YOU TO READ THE PROGRAM OF THE CONFERENCE “TOPICAL ISSUES OF THERAPY AND GENERAL MEDICAL PRACTICE”

05/18/2023

To the attention of graduates, students and residents!
The annual large-scale event at the Ryazan Medical University – Job Fair 2023 – will be held on Tuesday, May 23 at 11 am in the foyer of the first and second floors of the medical and preventive building (Vysokovoltnaya st. , 7 building 1)!

05/17/2023

WE INVITE YOU TO JOIN THE ONLINE CONFERENCE
Dear Colleagues! 18 and 19May, the online conference “Psychological Research of Appearance and Body Image” is held by the Department of Clinical Psychology

05/17/2023

Day of the Lipetsk region in the Ryazan State Medical University
We invite graduates and students on May 18 to the Center for Culture and Leisure of the University for the “Day of the Lipetsk Region”.

05/16/2023

May 17 – World Hypertension Day
In the clinical divisions of the Ryazan State Medical University, as well as on the territory of the medical campus, from 12. 00 to 15.00, the action “Find out your pressure here and now!” At organized sites, university staff and students will measure the pressure of everyone.

Announcements

Session 11. Antidepressants and antiepileptics

11

Purpose
classes: form
ideas about the origin
antiepileptic and antidepressant
drug effect. Based on knowledge
their pharmacokinetics and pharmacodynamics,
as well as side effects and contraindications
be able to choose drugs for treatment
epilepsy and depression.

Questions and tasks for self-preparation of students for the lesson:

1. Classification,
   localization and mechanism of action
   antiepileptic drugs.

2. Facilities,
   used to treat large and
   focal epileptic seizures
   (phenobarbital, difenin, carbamazepine,
   acediprol, lamotrigine, topiramate,
   oxcarbazepine, levetiracetam, vigabatrin,
   felbamate). Pharmacodynamics and pharmacokinetics
   drugs. Comparative characteristics.
   Other pharmacological properties
   drugs (hypnotics, analgesics,
   muscle relaxant and others). Peculiarities
   applications.

3. Preparations
   for the treatment of small epileptic
   seizures (ethosuximide, pufemid,
   felbamate, clonazepam, trimetine, acediprol,
   Cavinton). Pharmacodynamics and pharmacokinetics
   Comparative characteristics of funds.
   Indications for use.

4. Preparations
   for the treatment of myoclonic seizures
   (ethosuximide, pufemide, clonazepam,
   sibazon).

5. Preparations
   for the treatment of status epilepticus
   (benzodiazepines, phenobarbital, general
   anesthetics).

6. Comparative
   characteristics of drugs used
   for the treatment of muscle spasticity and
   febrile seizures (tizanidine, dantrolene,
   mydocalm).

7. Side effects
   effects of major antiepileptic
   funds.

8.
Classification
antidepressants:

I.
Indiscriminate
neuronal blockers
monoamine capture:

imipramine,
amitriptyline, azafen, maprotiline

II.
Electoral
neuronal blockers
serotonin uptake:

milnacipran,
sertraline, fluoxetine

III.
Inhibitors
monoamine oxidase
(MAO)

nialamide,
befol, inkazan, moclobemide, pyrazidol

IV.
Atypical antidepressants: trazodone,
mirtazapine, tianeptine, mianserin

9.
Mechanisms of development of antidepressant
actions of drugs of different groups. Other
pharmacological effects of antidepressants.
Comparative characteristics
antidepressants
according to the scheme:
mechanism
actions, pharmacological effects and
indications for use. Side effects
effects of antidepressants.

Independent work

Compose
tables
on pharmacological and clinical
efficacy and safety of drugs:
phenobarbital, difenin, acediprol,
ethosuximide, clonazepam, imipramine,
amitriptyline, moclobemide, trazodone.

Clinical and pharmacological efficacy of drugs