Does tramadol make you gain weight: Does Flexeril and/or tramadol cause weight gain?
Tramadol and Weight gain, a phase IV clinical study of FDA data
Weight gain is found among people who take Tramadol, especially for people who are female, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Tramadol and have Weight gain. It is created by eHealthMe based on reports of 194,214 people who have side effects when taking Tramadol from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
On Apr, 07, 2023
194,214 people reported to have side effects when taking Tramadol.
Among them, 3,141 people (1.62%) have Weight gain.
What is Tramadol?
Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 200,114 Tramadol users for its effectiveness, alternative drugs and more.
What is Weight gain?
Weight gain is found to be associated with 3,942 drugs and 3,845 conditions by eHealthMe.
Number of Tramadol and Weight gain reports submitted per year:
Time on Tramadol when people have Weight gain *:
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Gender of people who have Weight gain when taking Tramadol*:
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Age of people who have Weight gain when taking Tramadol *:
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Common drugs people take besides Tramadol *:
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Common side effects people have besides Weight gain *:
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Common conditions people have *:
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* Approximation only.
Some reports may have incomplete information.
Do you take Tramadol and have Weight gain?
Check whether Weight gain is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Mansour HM, “Tramadol and Disseminated Intravascular Coagulopathy: A Case Report”, Medicine Science, 2015 Jan .
- Eslami Shahrbabaki M, Nasirian M, Eslami Shahrbabaki P, “Extreme Weight Gain due to Short-term Use of Low-dose Propranolol”, Journal of Mazandaran University of Medical Sciences, 2015 Jan .
Related studies
How severe was Weight gain and when was it recovered:
- Weight gain in Tramadol
Expand to all the drugs that have ingredients of
tramadol hydrochloride:
- Weight gain and drugs with ingredients of tramadol hydrochloride (3,731 reports)
Alternative drugs to, pros and cons of Tramadol:
- Tramadol (200,114 reports)
Common Tramadol side effects:
- Pain: 14,785 reports
- Fatigue (feeling of tiredness): 12,058 reports
- Drug ineffective: 10,171 reports
- Headache (pain in head): 9,391 reports
- Diarrhea: 9,053 reports
- Nausea and vomiting: 8,804 reports
Browse all side effects of Tramadol:
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Weight gain treatments and more:
- Weight gain (238,319 reports)
COVID vaccines that are related to Weight gain:
- Weight gain in Moderna COVID Vaccine
- Weight gain in Pfizer BioNTech Covid Vaccine
- Weight gain in Johnson and Johnson Covid Vaccine
Common drugs associated with Weight gain:
- Prednisone: 18,993 reports
- Lyrica: 12,245 reports
- Methotrexate: 11,836 reports
- Risperdal: 9,118 reports
- Aspirin: 8,715 reports
- Humira: 8,227 reports
- Metformin: 7,862 reports
- Synthroid: 7,760 reports
- Enbrel: 6,641 reports
- Abilify: 6,390 reports
All the drugs that are associated with Weight gain:
- Weight gain (3,942 drugs)
Common conditions associated with Weight gain:
- Rheumatoid arthritis: 16,063 reports
- Depression: 10,701 reports
- High blood pressure: 8,581 reports
- Pain: 7,919 reports
- Crohn’s disease: 7,365 reports
- Multiple sclerosis: 6,565 reports
- Birth control: 6,336 reports
All the conditions that are associated with Weight gain:
- Weight gain (3,845 conditions)
How the study uses the data?
The study uses data from the FDA.
It is based on tramadol hydrochloride (the active ingredients of Tramadol) and Tramadol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.
com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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Weight gain after getting off of Tramadol Hydrochloride | Narcotic (Opioids) Drugs Dependence discussions | Emotional & Mental Health center
bubble08
I was on Tramadol/ Ultram for over a year now. I recently realized that I was taking them habitually instead of only when needed, so I stopped cold turkey. I went through a really bad week of withdrawals, but everything is better now. That was about three weeks ago and since then, I have gained over 10 pounds & all of my clothes are tight! I actually eat healthier, excercise more often, and take better care of myself now than I did on the drugs… I know that I had more energy to keep going & going on the Tramadol, but why such an increase in weight so quickly? (It’s definitely not muscle).
Also, I have a feeling of fullness in my legs constantly and was wondering if there is any relation there as well. Thank you for any advice, stories, support, etc…
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Guest
Hi Bubble08,
I can only speak from personal experience…I have been taking a very high dose of tramadol for about 2.5 years now, and have noticed significant weight gain throughout the past 2 years. I have not done anything different (lifestyle wise) except take tramadol. Eating and exercise habits have remained the same and yet I have put on a total of 30 lbs over 2 years! So, I do believe Tramadol has the ability to have an effect on weight. I just read a recent study about how a psyciatrist effectively treated an anorexic patient of hers with 50 mg of Tramadol a day and after 2 months she gained 13 lbs.
!
Hope this helps!
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Guest
Hello!
I have been on Tramadol for about a year now and have gained about 20 pounds. I also have not had any lifestyle changes, and had a very puffy stomach-my pharmacist thought I was expecting!! Ugh!! Now that Im doing some research, Im finding it is also just as if not more addictive than any opiate painkiller out there. Please be careful, quitting this is not pleasant.
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Guest
I have been on Tramadol now for 4 months and have lost around 9lbs.
I am doing nothing different, and the pounds are dropping off. I am a UK size 10 (I think that’s a US size 6), and was a healthy weight and size. My doctor is now considering changing my painkillers to something different as he is worried about this side effect. I am now worried that when I stop the Tramadol I will see significant and fast weight gain. Anyone else had this side effect?
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Guest
Hello, I started using Tramadol 50mg in Oct 2008 for knee pain in both knees…my dr. Prescribed this medication to a 28 yr old. Starting I Feb 2009 I noticed that I was gaining weight..this has continued and I have gained @ 30lbs in the last year or so. A direct correlation to my starting the medication. Switched to a different pahrmacy and even though the perscription was the same, the drug maker changed and the new med brand was MUCH stronger.
Has anyone else had this weight gain happen to them. Has anyone stopped taking Tramadol and lost the weight? Thank you!
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Guest
Hi
I took tramadol for 2.5 years and I have had weight problems ever since. I gained over 60lb and have difficulty losing it. I also notice huge fluctuations in weight. I also eat a healthy diet and exercise. i am getting quite upset about it all!
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niagrafalls99
in 2 years I gained 60 lbs!!! I didn’t change anything about my diet and excercise but I still got F.
A.T. …AND your stomach gets and stays really puffy and hard to the touch.
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Guest
Strange…I started taking tramadol and within 2 months lost 30 lbs.
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weightgain2012
I took tramadol for 1.5 years and lost 10 lbs. I stopped taking it 6 months ago and have had a 15 lbs weight gain! I eat VERY healthy and exercise. How much longer is this going to go on? I need to know when will my bodies metabolism go back to normal.
If there is anyone out there that has been off tramadol for a long time and have any insight to this please respond.
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dace2talon
I was on tramadol for a little over a year and have been off since December and since then have gained 15 pounds. My exercise and eating habits are not any different. This sucks!!. I hate this medicine!
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lookingprego
I had the same thing happen to me.. literally gained 15 lbs in less than 3 months..once I stopped taking the tramadol…I am wondering when it will be back to normal. My weight gain seems only in my abdomen. Where was yours?
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Filly239938
I was on Tramadol for 3 years after a serious bike accident. I went cold turkey about 6 weeks ago now. The first week was absolutely terrible but I was really proud of myself that I persevered and am now free of them after a previous failed attempt to get off them. But now I just seem to be getting bigger and bigger. I am eating very healthily (I always have) and am at he gym more now than I was before just because I was so concerned about this sudden weight gain. I go 4 times a week and really work hard. I’ve put on about a stone so far in the last 6 weeks for no apparent reason other than what I can only put down to Tramadol withdrawals? Its really troubling me and its so frustrating because nothing I am doing is helping.
The weight just seems to pile on. None of my trousers, jeans, skirts etc fit me at all anymore? Even clothes that used to be baggy will not even do up now? I am going to try and get to the doctors tomorrow to see if theres anything they can give me to help but I’m worried that they’re going to tell me thats its all in my head. Has anyone help us??!! Please!
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nobiku
In 18 months on tramadol I burned 135 pounds of fat! Of course, I changed my diet and exercised, but something about tramadol helped me to transform. My only complaint is it eventually causes severe depression. The euphoria is short lived, but if taken with the right mindset it can take a morbidly obese slob and turn them into a stud…a depressed stud, but a stud nonetheless! It is 50mg of will power!!!
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guntar492
Have you noticed when taking tramadol you get very thirsty.Tramadol dehydrates you and if you stop taking it you can put on a lot of water weight.I have taken it for many years and its terrible.Your body will get back to normal,it may take a year.
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pinkiepink
Hello all,
I have been on trammies fir about 5 years now I take 8 a day usually if not 12 maybe 13 and fly for a good 8 hours. As for the weight gain, wrong I llooked like a skeleton compared to the size 18 I was now I went from a size 10 back to a 14.
When I run out of them and it is always a good 10 days early then I eat cause I am so so depressed..So my thinkink is this,,it’s all in your state of mind ((grins))
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When beauty requires sacrifice – literally
Subscribe to our newsletter “Context”: it will help you understand the events.
Image caption,
Pills with weight gain as a side effect are not so difficult to obtain from illegal vendors
More and more young girls in Sudan are turning to drugs that can only be obtained on the black market. And this is done only for the sake of beauty.
While skin whitening has long been a staple beauty treatment among Sudanese women, a new trend has been gaining momentum.
Many young girls start using prescription-only pills to gain weight. Such is now the ideal of beauty in this country – to be the owner of a magnificent figure.
Weight-gaining pills are sold illegally in the same shops that sell whitening creams and other popular beauty products.
They are sold in small bags or empty candy boxes, and customers do not even realize the risk these pills pose to their health.
- “Healthy fatness” is a myth
An alleged secret
It is difficult to estimate how many women in Sudan use these pills, because many of them simply refuse to admit it.
“Pills are distributed in the villages like candy,” says Imitithal Ahmed, a student at the University of Khartoum, “I was always afraid of these pills because I saw how they made my family feel sick and how my friends got hooked on appetite stimulants.
My aunt is now on the verge of kidney failure, she has a lot of plaque in her blood vessels – and all this is because she took too many of these pills because she wanted a big butt.
Everyone in the family knows why the aunt is sick, but she is not going to admit it. She had to give up these pills on the advice of a doctor.”
- Beauty for all time is just a myth?
“My mother suspects”
to their action – so desired by many women.0005
“The Neighbors’ Shock”, “Chicken Thighs”, “My Mom Suspects” – the clinical title is replaced by promises of a big booty, plush thighs and a belly that will make your mom assume you’re pregnant.
Tablets range from common appetite stimulants to allergy medications containing the steroid hormone cortisone.
Image copyright AFP
Image caption
Sudan’s ideal of beauty is a fair-skinned, plump woman
The side effects of cortisone have now become rich ground for the distributors of these pills. This hormone is known for slowing down metabolism, increasing appetite, retaining water in the body and creating fat deposits in the abdomen and face.
According to Salah Ibrahim, head of the Sudan Pharmacists Union, uncontrolled use of steroids can harm the heart, liver, kidneys and thyroid gland.
- Norwegian scientists: steroids stay in the muscles for years
He explains that cortisone is produced naturally, helping to regulate the body’s vital functions. And when artificially synthesized concentrated doses of this hormone enter the human body in the form of such pills or skin-whitening creams, the brain gives a signal to stop its production.
When a person abruptly stops taking a hormonal remedy, his most important organs may stop functioning normally.
Terrible consequences
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Health officials say young women in Sudan are dying of acute kidney failure or cardiac arrest caused by abrupt withdrawal of steroids.
Fatalities are especially common among brides, who traditionally dedicate a whole month before their wedding to beauty treatments, after which they abruptly stop taking weight gain pills and steroid bleaching creams. The cause of their deaths is the sudden failure of an organ.
Despite this, such beauty trends still continue to attract the fair sex.
The abuse of prescription pills is on the rise in Sudan’s conservative society because it’s not really considered reprehensible, after all, the pills don’t smell like alcohol or marijuana.
University students buy the powerful painkiller Tramadol in bulk, which costs 20 Sudanese pounds ($1.8) per pill.
Some of the roadside tea vendors in Khartoum can even add a painkiller directly to the tea, for which the customer needs to say a code word.
Image copyright, YOUTUBE
Image caption,
Many women in Sudan see singer Nada Algalaa as the ideal of beauty
Awareness campaigns have so far failed to materialize.
Dr. Ibrahim has repeatedly appeared on national television to warn of the dangers of overusing such pills.
At the university level, future pharmacists are trained to be vigilant and follow the requirements of the law and ethics.
But in a country where doctors and pharmacists are paid very little, the temptation to sell pills to illegal distributors becomes decisive.
“The last time I went shopping for my creams, the owner of the store took out a box of chocolates that was full of different pills that lead to weight gain,” says student Imitithal Ahmed. “Out of fear of embarrassment, girls do not ask pharmacists and doctors about the pills they buy in those stores.”
Police may be arresting vendors and blocking smuggling channels, but drug scammers’ profits are still on the rise. Pills go to the black market, which is considered the lesser evil.
Sudan is not the only African country where fullness is considered a symbol of power and prosperity and increases the chances of marriage among young girls.
However, it is in this country that fullness becomes the ideal.
It is here that she defines what a written beauty and a desirable wife should be – full and fair-skinned.
The iconic image of the singer Nada Algalaa, whom people admire and try to imitate, is another proof of this.
For some women, this becomes a goal for which absolutely all means are good, without exception. Even if they endanger their health and life.
Weight gain drugs – indications and contraindications
To improve physical performance, bodybuilders, bodybuilders and athletes buy weight gain drugs. One of the most popular varieties of such drugs are drugs that contain peptides. The class of medical devices in most cases is effective when an athlete needs a quick and high-quality weight gain.
Weight gain preparations with peptides
Peptides in weight gain preparations consist of protein fragments. Depending on the type of peptide preparation, the protein can be of both artificial and natural origin.
Amino acid residues in the composition of medical products are linked by a peptide bond, which is why they are called so. Otherwise, weight gain drugs with peptides are called “information agents.” The active substance is responsible for the transfer of data between the smallest particles of the body.
Peptide-based weight gainers have the following effects on the body:
- gain muscle mass;
- balance of body functioning;
- stress reduction;
- Increased stamina and strength.
The advantage of weight gain preparations with peptides is that they are easily absorbed, and the risk of negative consequences for the body during the course is minimized.
The best weight gain drugs with peptides
In sports pharmacology, there are 10 weight gain drugs with peptides that are in consistently high demand among athletes:
- Thymosin beta-4;
- Sermorelin;
- PEG-MGF;
- Melanotan 1;
- Melanotan 2;
- Ipamorelin;
- IGF1-LR3;
- GH FRAG 176-191;
- Hexarelin;
- GHRP-6 and GHRP-2;
- CJC-1295 DAC.
