How do Cymbalta and Lexapro differ in treating depression and anxiety. What are the key similarities and differences between these antidepressants. Which medication may be more effective for certain conditions.

Overview of Cymbalta and Lexapro

Cymbalta (duloxetine) and Lexapro (escitalopram) are two commonly prescribed antidepressant medications used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). While they have similar mechanisms of action involving serotonin levels in the brain, there are some key differences between these drugs.

Cymbalta is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by increasing levels of both serotonin and norepinephrine in the brain. Lexapro, on the other hand, is a selective serotonin reuptake inhibitor (SSRI) that specifically targets serotonin levels.

Key Differences Between Cymbalta and Lexapro

• Drug class: Cymbalta is an SNRI, Lexapro is an SSRI
• Generic names: Duloxetine vs. Escitalopram
• Standard dosage: Cymbalta 60mg daily, Lexapro 10mg daily
• Available strengths: Cymbalta – 20mg, 30mg, 60mg; Lexapro – 5mg, 10mg, 20mg
• Dosage forms: Cymbalta – oral capsule; Lexapro – oral tablet and solution
• Age groups: Cymbalta approved for ages 7+ (GAD) and 12+ (MDD); Lexapro approved for adults

Conditions Treated by Cymbalta and Lexapro

While both medications are approved to treat major depressive disorder and generalized anxiety disorder, they each have some unique indications as well:

Cymbalta FDA-Approved Uses

• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)
• Diabetic peripheral neuropathic pain
• Fibromyalgia
• Chronic musculoskeletal pain

Lexapro FDA-Approved Uses

• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)

Lexapro is also prescribed off-label for conditions like panic disorder, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder. Off-label prescribing means using a medication to treat a condition not officially approved by the FDA, which is legal but should be discussed thoroughly with your doctor.

Effectiveness of Cymbalta vs Lexapro

Comparative studies have shown some differences in the effectiveness and tolerability of Cymbalta and Lexapro:

• Short-term depression treatment: Lexapro was found to be superior to Cymbalta
• Long-term depression treatment: Lexapro was as effective as Cymbalta but more tolerable
• Withdrawal rates: 8% higher for Cymbalta compared to Lexapro due to adverse reactions

However, it’s important to note that individual responses to antidepressants can vary greatly. The most effective medication for you may depend on your specific symptoms, medical history, and other factors.

Side Effects and Tolerability

Both Cymbalta and Lexapro can cause side effects, but their profiles differ somewhat:

Common Side Effects of Cymbalta

• Nausea
• Dry mouth
• Constipation
• Fatigue
• Decreased appetite
• Increased sweating

Common Side Effects of Lexapro

• Nausea
• Insomnia
• Sexual dysfunction
• Drowsiness
• Dry mouth
• Dizziness

Studies have suggested that Lexapro may be better tolerated overall, with fewer patients discontinuing treatment due to side effects compared to Cymbalta.

Drug Interactions and Precautions

Both Cymbalta and Lexapro can interact with other medications and substances. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking.

Notable Interactions

• MAO inhibitors: Both drugs can cause serious interactions with MAOIs
• NSAIDs: Cymbalta may increase the risk of bleeding when combined with NSAIDs
• Alcohol: Both medications can interact with alcohol, potentially increasing side effects
• Other serotonergic drugs: Combining either medication with other drugs that affect serotonin levels can increase the risk of serotonin syndrome

Do antidepressants like Cymbalta and Lexapro carry any serious risks? Yes, both medications carry a boxed warning about the increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Close monitoring is essential, especially during the first few months of treatment or after dose changes.

Dosage and Administration

The dosage of Cymbalta and Lexapro can vary depending on the condition being treated and individual patient factors:

Cymbalta Dosage

• Major Depressive Disorder: Usually 40-60mg per day, starting at 30mg
• Generalized Anxiety Disorder: 60mg once daily
• Diabetic Peripheral Neuropathic Pain: 60mg once daily
• Fibromyalgia: 60mg once daily

Lexapro Dosage

• Major Depressive Disorder: Usually 10mg once daily, can be increased to 20mg
• Generalized Anxiety Disorder: 10mg once daily

How should these medications be taken? Both Cymbalta and Lexapro can be taken with or without food. It’s important to take them at the same time each day and not to abruptly stop taking either medication without consulting your doctor.

Cost and Insurance Coverage

The cost of Cymbalta and Lexapro can vary depending on factors such as insurance coverage, pharmacy pricing, and whether you’re using brand-name or generic versions.

• Generic versions (duloxetine and escitalopram) are typically more affordable than brand-name versions
• Many insurance plans cover both medications, but copays and tier placements may differ
• Patient assistance programs may be available for those who qualify

It’s advisable to check with your insurance provider and local pharmacies to compare costs. Generic versions are often significantly less expensive and equally effective as their brand-name counterparts.

Special Considerations and Populations

Certain groups may require special consideration when using Cymbalta or Lexapro:

Pregnancy and Breastfeeding

Both medications are classified as Pregnancy Category C drugs, meaning potential risks to the fetus cannot be ruled out. The decision to use these medications during pregnancy or while breastfeeding should be made in consultation with a healthcare provider, weighing the potential benefits against the risks.

Elderly Patients

Older adults may be more sensitive to the effects of these medications and may require lower doses. They may also be at higher risk for certain side effects, such as hyponatremia (low sodium levels).

Liver or Kidney Impairment

Patients with liver or kidney problems may need dose adjustments or may not be suitable candidates for these medications, particularly Cymbalta in the case of severe liver impairment.

Children and Adolescents

Cymbalta is approved for use in children 7 years and older for GAD, and 12 years and older for MDD. Lexapro is approved for adolescents 12-17 years old for MDD. The use of these medications in younger populations requires careful monitoring due to the increased risk of suicidal thoughts and behaviors.

Are there any lifestyle changes that can complement antidepressant treatment? Yes, several lifestyle modifications can enhance the effectiveness of antidepressant medications:

• Regular exercise
• Maintaining a healthy sleep schedule
• Practicing stress-reduction techniques like meditation or yoga
• Engaging in psychotherapy or counseling
• Building a strong support network
• Avoiding alcohol and recreational drugs

These lifestyle changes, when combined with appropriate medication, can significantly improve outcomes for individuals dealing with depression or anxiety disorders.

Switching Between Cymbalta and Lexapro

In some cases, a healthcare provider may recommend switching from one antidepressant to another. This process requires careful management to minimize withdrawal symptoms and ensure continued efficacy.

Cross-Tapering Method

One common approach is cross-tapering, where the dose of the current medication is gradually reduced while the new medication is introduced at a low dose and slowly increased. This method can help minimize discontinuation symptoms and allow for a smoother transition.

Potential Challenges

• Discontinuation syndrome: Abruptly stopping either medication can lead to withdrawal-like symptoms
• Adjustment period: It may take several weeks to determine the effectiveness of the new medication
• Side effect profile changes: The patient may experience different side effects with the new medication

How long does it typically take to see improvement when starting a new antidepressant? While some people may notice improvements in sleep, appetite, or energy levels within the first 1-2 weeks, it often takes 4-6 weeks to experience the full therapeutic effects of antidepressants like Cymbalta or Lexapro.

It’s crucial to work closely with a healthcare provider when considering a switch between antidepressants. They can provide personalized guidance based on your specific situation and medical history.

Long-Term Use and Prognosis

Both Cymbalta and Lexapro are often prescribed for long-term use in the treatment of chronic conditions like major depressive disorder and generalized anxiety disorder.

Long-Term Efficacy

Studies have shown that both medications can be effective for long-term management of depression and anxiety. Some patients may need to continue treatment for several months or even years to maintain symptom relief and prevent relapse.

Monitoring and Adjustments

Regular follow-ups with a healthcare provider are important for:

• Assessing ongoing effectiveness
• Monitoring for side effects
• Adjusting dosage as needed
• Evaluating the need for continued treatment

Discontinuation

If it’s determined that the medication is no longer needed, a gradual tapering of the dose under medical supervision is typically recommended to minimize discontinuation symptoms.

Can long-term use of antidepressants like Cymbalta or Lexapro lead to dependence? While these medications are not considered addictive in the traditional sense, the body can become accustomed to their effects. This is why it’s important to work with a healthcare provider when considering stopping or changing antidepressant medication.

The long-term prognosis for individuals using Cymbalta or Lexapro can be positive, especially when combined with other forms of treatment like psychotherapy and lifestyle changes. However, individual responses can vary, and what works best may differ from person to person.

In conclusion, while Cymbalta and Lexapro share some similarities in their use for treating depression and anxiety, they also have distinct differences in their mechanisms of action, side effect profiles, and additional approved uses. The choice between these medications should be made in consultation with a healthcare provider, taking into account individual factors such as specific symptoms, medical history, potential drug interactions, and personal preferences. Regular follow-up and open communication with your healthcare team are key to ensuring the most effective and well-tolerated treatment plan.

Cymbalta vs. Lexapro: Similarities, Differences, & Side Effects

About 13.2% of adults in the U.S. take antidepressants.

Of the many types of antidepressants available, Cymbalta and Lexapro are commonly prescribed for the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD). 

You may be experiencing adverse reactions with your current medication and considering your other options.

Although these two drugs have a similar mechanism of action—both affect the levels of serotonin in the brain—there are some differences.

In this article, we’ll discuss the differences and similarities between Cymbalta and Lexapro, the conditions they treat, and their effectiveness.

We’ll also compare the coverage and the cost of the medication, the common side effects, and the possible drug interactions of Cymbalta and Lexapro.

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What Are the Differences & Similarities Between Cymbalta and Lexapro?

Cymbalta and Lexapro are prescription drug antidepressants used to treat major depression and generalized anxiety disorder.  

Cymbalta, the brand name for duloxetine, is a serotonin-norepinephrine reuptake inhibitor (SNRI).

This class of antidepressants works by preventing the reuptake (reabsorption) of two neurotransmitters in the brain called serotonin and norepinephrine. 

The resulting increased levels of these chemical messengers helps to relieve symptoms of major depressive disorder and generalized anxiety disorder.

The FDA has also approved Cymbalta for the treatment of some pain conditions. 

Lexapro, the brand name for escitalopram, is a selective serotonin reuptake inhibitor (SSRI).

It works by preventing the reuptake of serotonin in the brain, thereby increasing the levels of available serotonin. 

Since serotonin is a neurotransmitter responsible for mood, sleep, and other bodily functions, increased amounts in the brain help ease symptoms of major depressive disorder and generalized anxiety disorder. 

The table below provides an overview of how the two antidepressant medications compare:

What Conditions Are Treated with Cymbalta and Lexapro?

Both Cymbalta and Lexapro are prescription medications for the treatment of major depressive disorder and generalized anxiety disorder.  

Cymbalta is also approved for treating some pain-related conditions, including fibromyalgia, diabetic peripheral neuropathic pain, and chronic musculoskeletal pain.

Cymbalta is the only antidepressant approved to treat neuropathic pain. 

Lexapro is prescribed off-label for the treatment of conditions such as panic disorder, premenstrual dysphoric disorder, and obsessive-compulsive disorder. 

When a doctor or healthcare provider prescribes a drug off-label, they prescribe it for a condition that the FDA has not approved.

Off-label prescription is not illegal, but your doctor should explain how the drug may help your condition.

Below is a summary of the conditions that Cymbalta and Lexapro are used to treat:

This list is not conclusive.

Consult your doctor to know which medication is suitable for you. 

Effectiveness of Cymbalta and Lexapro

A comparative study of escitalopram (Lexapro) and duloxetine (Cymbalta) found that escitalopram was superior to duloxetine for short-term treatment of depression.

The researchers also concluded that escitalopram is as effective as and more tolerable than duloxetine for long-term treatment.

Due to adverse reactions, the withdrawal rate of patients on duloxetine was 8% higher than that of patients on escitalopram. 

Another study showed similar results: Escitalopram was better tolerated and at least as effective as duloxetine for treating major depressive disorder.

This is not to say that Lexapro is better than Cymbalta for treating depression, but rather that people were more likely to discontinue Cymbalta due to common adverse reactions.

Coverage & Cost of Cymbalta and Lexapro

Medicare and commercial insurance plans usually cover at least some of the cost of both generic versions and brand-name Cymbalta and Lexapro.  

The exact cost of your medication varies depending on the brand and dosage, as well as your insurance and pharmacy.

A month’s supply of 30-milligram Cymbalta can cost almost $390, while a month of 20-milligram Lexapro can cost up to $260.

You may be able to save money using coupon codes with participating pharmacies.

Common Side Effects of Cymbalta and Lexapro

Cymbalta and Lexapro share similar side effects, although some are more pronounced using one drug than the other.

The table below covers the possible side effects, though this list is not exhaustive.

Most symptoms do not last past the first few weeks of starting either medication.

If you experience any of these symptoms, speak with your doctor.

They can help you manage them and, depending on how severe they are, may suggest switching to another antidepressant.

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Drug Interactions & Warnings 

Cymbalta and Lexapro can have unpleasant reactions with other drugs.

Before starting either medication, inform your doctor of the other medicines you’re using, including vitamins and supplements.

Cymbalta and Lexapro should not be used within 14 days of using any monoamine oxidase inhibitors (MAOIs).

This class of antidepressants includes:

• Isocarboxazid (Marplan)
• Phenelzine (Nardil)
• Selegiline (Emsam)
• Tranylcypromine (Parnate)
• Linezolid (Zyvox)
• Intravenous methylene blue

Cymbalta and Lexapro also interact with other serotonergic medications such as:

• Tricyclic antidepressants
• Triptans
• Lithium
• Fentanyl
• Buspirone
• Tramadol
• Tryptophan
• St. John’s wort
• Amphetamine

Lastly, using Cymbalta and Lexapro with aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anticoagulants increases bleeding risk, including life-threatening hemorrhages.

Cymbalta or Lexapro also have side effects of their own.

People taking either medication for major depressive disorder or other psychiatric disorders are at risk for increased suicidal thoughts and behavior.

If you have any concerning thoughts, seek care immediately.

How K Health Can Help 

Your choice of an antidepressant can affect the quality of your life. You need to consult a doctor to know which treatment plan will be best for you.

Think you might need a prescription for Cymbalta (duloxetine) or a prescription for Lexapro (escitalopram)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine which prescription is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.

Frequently Asked Questions

Which is better for depression, Cymbalta or Lexapro?

Studies show that duloxetine (Cymbalta) and escitalopram (Lexapro) are equally effective at treating major depressive disorder long term. However, a randomized controlled trial reported that escitalopram was better tolerated. Your doctor can discuss all of the pros and cons with you when prescribing the right antidepressant for you.

Is Cymbalta a good replacement for Lexapro?

Since Cymbalta and Lexapro have similar efficacy in the treatment of depression, it can be a suitable replacement. One concern is that Cymbalta tends to be less tolerated, so people may be more likely to discontinue the medication. Also, Lexapro is prescribed off-label for some conditions that Cymbalta cannot be used for. Your doctor or healthcare provider can provide you with more information about whether it is a good choice for you.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

K Health has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions,
and medical associations. We avoid using tertiary references.

• Antidepressant Use Among Adults: United States, 2015–2018. (2020).
  https://www.cdc.gov/nchs/products/databriefs/db377.htm

• A Comparative Study of the Efficacy of Acute and Continuation Treatment With Escitalopram Versus Duloxetine in Patients With Major Depressive Disorder. (2007).
  https://pubmed.ncbi.nlm.nih.gov/17559755/

• Cymbalta Prices, Coupons and Patient Assistance Programs. (n.d.).
  https://www.drugs.com/price-guide/cymbalta

• Double-Blind Comparison of Escitalopram and Duloxetine in the Acute Treatment of Major Depressive Disorder. (2007).
  https://pubmed.ncbi.nlm.nih.gov/17563128/

• Lexapro Prices, Coupons and Patient Assistance Programs. (n.d.).
  https://www.drugs.com/price-guide/lexapro

• The Use of Antidepressants in the Treatment of Irritable Bowel Syndrome and Other Functional GI Disorders. (n.d.).
  https://www.med.unc.edu/ibs/wp-content/uploads/sites/450/2017/10/IBS-and-Antidepressants.pdf

Zoloft vs. Cymbalta: Similarities, Differences, & Side Effects

Cymbalta (duloxetine) is an antidepressant medication that falls under the medication category of selective serotonin-norepinephrine reuptake inhibitors (SNRIs). 

Zoloft (sertraline) is also an antidepressant medication but is a selective serotonin reuptake inhibitor (SSRI), which functions differently from SNRIs. 

While both medications are widely popular for treating mental health conditions such as depression (major depressive disorder), they have similarities and differences. 

In this article, we’ll compare Zoloft and Cymbalta by going over the conditions they’re used to treat, cost differences, potential side effects, and what you need to know to take Zoloft or Cymbalta safely.

What Are the Similarities & Differences Between Zoloft and Cymbalta?

Both medications are used to treat a variety of symptoms and mental health conditions. One of the biggest differences between Zoloft and Cymbalta is the medication class they’re in. 

Selective serotonin reuptake inhibitors (SSRIs) such as Zoloft work to increase the amount of serotonin in the brain and body to improve mood, stress, sleep, and metabolism. 

Selective serotonin-norepinephrine reuptake inhibitors (SNRIs) such as Cymbalta work to increase the amount of norepinephrine and serotonin in the brain and body to improve mood, stress, and pain symptoms. 

Here are some other comparisons of Cymbalta and Zoloft.

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What Conditions Are Treated with Zoloft and Cymbalta?

Zoloft and Cymbalta both treat various neurological and psychological disorders. The table below compares the conditions each medication treats.

One important difference between Zoloft and Cymbalta is that Cymbalta, an SNRI, is sometimes used to treat nerve pain symptoms. 

Research is yet to discover the particular mechanism behind how Cymbalta helps with pain, and studies are still exploring how Cymbalta affects patients with osteoarthritis, fibromyalgia, and other neuropathic pain. 

Zoloft has been on the market longer, as it was approved by the Federal Drug Administration (FDA) in 1990. Cymbalta was approved in 2004. 

This means that Zoloft has had more time to be extensively tested for a variety of symptoms and disorders. It is also one of just four medications approved by the FDA to use for children with obsessive-compulsive disorder (OCD). 

*  Off-label means it can be used for the condition but is not an official indication

Which Is More Effective, Zoloft or Cymbalta?

Each drug has been tested vigorously for a variety of health conditions and psychological disorders. Depending on which health concern you have, one may have more benefits over the other, and your healthcare provider will talk to you about which one may be best.

Some studies have directly compared Zoloft (sertraline) and Cymbalta (duloxetine) for patients with clinical depression. 

One study compared 63 patients who took either sertraline or duloxetine to treat Major Depressive Disorder (MDD). It found that the medications were overall similar for treatment efficacy, but each worked better for certain symptoms. 

Zoloft was more effective for symptoms relating to anxiety, agitation, and excessive fears of having an illness. But Cymbalta was more effective for treating physical symptoms slowed movement/thinking, and sexual problems.

Depending on your medical history, other current medications, and specific symptoms, either Zoloft or Cymbalta may be a better choice for you. Your healthcare provider will be able to work with you to determine which medication will be most effective for your needs.

Cost & Coverage of Zoloft vs. Cymbalta

Costs for prescriptions vary by state and city. The available insurance coverage for Zoloft and Cymbalta also differs depending on the area you live in.

Both Zoloft and Cymbalta are typically covered by commercial and Medicare/Medicaid healthcare plans, but costs can vary if you do not have prescription coverage or have to pay a copayment for prescriptions.

Like any other medication, the brand name is typically more costly than the generic brand.

The average cost for 30 days of brand-name 50mg Zoloft capsules is around $140. If you choose a generic brand of sertraline, a 30-day treatment may only cost $13.

The average cost for 30 days of brand-name 60mg Cymbalta capsules is around $390. If you choose a generic brand of duloxetine, a 30-day treatment is only around $20. 

What are the Side Effects of Zoloft and Cymbalta?

Zoloft and Cymbalta each have common side effects. See the table below for the most common side effects of each medication. This list does not include all of the possible side effects. 

If you are considering taking Zoloft or Cymbalta, be sure to ask your healthcare provider about any potential side effects.

Zoloft and other SSRIs can also sometimes cause weight gain. While the mechanisms behind the weight gain is not fully understood by experts, it may have something to do with changes in metabolism or appetite.

There is also data that shows some patients experience weight loss when they initially start Cymbalta.

Talk to your healthcare provider before stopping any antidepressant. 

If you stop taking Zoloft, Cymbalta, or another antidepressant without slowly reducing your dosage, you might experience uncomfortable symptoms or even antidepressant discontinuation syndrome. 

Symptoms of this syndrome include nausea, vomiting, headaches, and other flu-like symptoms. To be safe, notify your healthcare provider if you begin to experience any of these symptoms.

You can take some over-the-counter medications to improve some symptoms, and they typically subside after a couple of weeks.

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Drug Interactions and Warnings

Starting a new antidepressant has the potential to increase the risk of suicidal thoughts and depressive symptoms. If you experience any suicidal thoughts or are considering suicide, go to the nearest medical facility for immediate care. 

You can also call the National Suicide Prevention Lifeline (Lifeline) at 988, or text the Crisis Text Line (text HELLO to 741741). These services are free, confidential, and available 24/7.

Both SSRIs like Zoloft and SNRIs like Cymbalta are known to have negative interactions with the following treatments and medications:

• Treatments for seizure disorders
• Treatments for psychosis and schizophrenia
• Antiplatelet medications
• Lithium
• Triptans for migraines
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen
• Tricyclic antidepressants (TCAs)
• Monoamine oxidase inhibitors (MAOIs)

Certain drug interactions can result in dangerous and even fatal consequences.

Be sure to discuss your medical history and current medications with your healthcare providerbefore beginning any new treatment or medication.

Pregnancy and Breastfeeding

If you become pregnant while taking Zoloft or Cymbalta, notify your healthcare provider immediately.

Some SSRIs and SNRIs can cause negative effects on pregnancy or cause birth defects. 

People who are breastfeeding should discuss their medication options with their healthcare provider. 

Many times SNRIs like Cymbalta are not recommended while breastfeeding, but some SSRIs like Zoloft are approved for use while breastfeeding. 

Serotonin Syndrome

Both Zoloft and Cymbalta affect serotonin levels in the brain and body.

If too much serotonin is present, serotonin syndrome may occur. Serotonin syndrome is more likely to happen when you take other medications that increase serotonin in the body.

Examples include taking multiple antidepressants at the same time or using supplements such as  St. John’s Wort. 

Serotonin syndrome is considered a medical emergency and you should seek immediate emergency care if you display the following symptoms:

• Hallucinations
• Uncontrolled muscle spasms
• Unusual agitation or restlessness
• Nausea and vomiting
• Black, bloody stool
• Fever
• Rapid heart rate
• Severe dizziness
• Loss of coordination

How K Health Can Help

Think you might need a prescription for Zoloft (Sertraline) or a prescription for Cymbalta (Duloxetine)?

K Health has clinicians standing by 24/7 to evaluate your symptoms and determine which prescription is right for you.

Get started with our free assessment, which will tell you in minutes if treatment could be a good fit. If yes, we’ll connect you right to a clinician who can prescribe medication and have it shipped right to your door.

Frequently Asked Questions

Which is better for depression, Zoloft or Cymbalta?

When treating depression and depressive disorders, each medication has its specific benefits. Some studies have shown that Zoloft was more effective for symptoms relating to anxiety, agitation, and excessive fear of having an illness. But Cymbalta was more effective for treating physical symptoms, slowed movement/thinking, and sexual problems. The better medication option for the treatment of depression depends on the individual.

Can you switch from Zoloft to Cymbalta?

If you find that you are unhappy with the medication you’re currently taking, speak with your healthcare provider to learn about alternatives. Switching from an SNRI to an SSRI (or from an SSRI to an SNRI) must be carefully considered, as these drugs can interact with other medications and treatments.

What is stronger, Zoloft or Cymbalta?

Neither drug is stronger than the other, and they each have their own ways of affecting the brain and body. If you are looking to treat specific symptoms while experiencing clinical depression, one medication may be recommended over the other.

K Health articles are all written and reviewed by MDs, PhDs, NPs, or PharmDs and are for informational purposes only. This information does not constitute and should not be relied on for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.

Antidepressant Lilly Simbalta – « How to take antidepressants correctly and reduce the intensity of side effects ➡️ Those who know these secrets have a lower risk of interrupting treatment | Efficiency and withdrawal syndrome | Duloxetine or Cymbalta, is there a difference? »

Today I want to talk about such a drug as Simbalta, aka duloxetine. It is an SSRI antidepressant. In simple words, antidepressants of this group affect not only serotonin as antidepressants of the SSRI group, but also norepinephrine. Below I will talk about my experience with Cymbalta.

Packaging .

The preparation is sold in a cardboard box with a neutral design. The front side shows the name of the drug, the active substance and the number of tablets in the package. I now have two boxes of 14 capsules left. Prior to this, at the beginning of the course of treatment, I bought the drug in 28 capsules per package. It costs twice as much.

It should be borne in mind that 14 capsules are not enough even to understand whether an antidepressant works or not. It is better to buy a large package. The box contains a blister with capsules.

This format is quite a significant minus. When taking antidepressants, you initially need to go to the drug with a micro dose. In this case, you should start taking 30 milligrams, or even 15. But not 60 milligrams at once. At such high dosages, the approach to the drug turns out to be quite tough.

On sale, as far as I know, there are capsules with a volume of 30 milligrams, but I have never come across them all the time. It is impossible to divide the capsule, although there is still one way. I’ll tell you more in the “experience” section.

Active ingredient.

The active ingredient of the drug is duloxetine. I want to note that duloxetine is a relatively new antidepressant. In general, all antidepressants of the SSRI and SNRI groups are the latest developments of scientists.

Cymbalta side effects.

When buying a drug inside, you can find instructions for use, which will include side effects. I want to say the following, some are afraid of taking drugs and believe that since there are side effects in the instructions, then they will certainly happen. It is not true. Many side effects of the company are listed simply to avoid litigation. In general, the presence of large peppery side effects in the first place indicates that the drug is well studied. It is worse when the instructions say that there will be no side effects, but they eventually appear.

Application experience.

I had a standard dosage of simbalta. One dose of the drug in the morning, the course is at least half a year, ideally a year. It is possible to take antidepressants for life, including simbalts. I didn’t need something like that. I went on the drug with 30 milligrams a day. I took a capsule and poured everything on a dry surface. Then I took the capsules from the room where I first poured out all the contents. I divided the “powder” of simbalty into two equal parts and filled it into capsules from omez. It turned out two capsules of 15 milligrams. You can use any capsules, not necessarily omez. It’s just the cheapest and it’s not a pity to throw it away. Thus, I was able to enter the drug with a relatively small dosage.

In the first two weeks of taking antidepressants of this group (SSRIs and SSRIs), the condition noticeably worsens. If before that there was depression, anxiety and other conditions, then they intensify. This is absolutely normal. I once read a review where someone complained that you see the drug is ineffective and generally only made it worse. I don’t understand how people write things like this. Surely the doctor did not warn them about the peculiarities of the action of antidepressants.

In the first two weeks of taking, not only the condition worsens, but also side effects appear. If you need to go to the required dosage for more than two weeks, then the side effects will be much longer. On average, everything goes away in 10-14 days after establishing the desired dosage. No one evaluates the effect of using an antidepressant earlier than after a month of using the drug. It is necessary to drink daily strictly at the same time. You can not drink the drug anyhow, since there will not be a single concentration in the blood. You need to drink antidepressants for at least half a year, even if all the symptoms of depression have disappeared much earlier. It’s all the gold standard of care. Sometimes the effect comes too late. For example, when I drank cipralex, I got the effect only after a month and a half from the start of the intake.

I had side effects when I started taking simbalia. They won’t get stuck because it’s all individual. All side effects went away after I got to 60 milligrams a day. About a week after reaching this dosage, the side effects began to decrease and completely disappeared. In order for the side effects to be less pronounced, it is necessary to start taking it with a lower dosage. All this must be agreed with the doctor. In principle, any good doctor talks about it.

Depression began to disappear after about three weeks from the start of taking simbalta. Every day the condition began to improve until all the symptoms were completely gone. I had depression caused by taking one drug. Simply put, depression was a consequence of treatment with another drug and, in fact, was a side effect. Pl past this was anxiety and panic attacks. In general, everything went away after a few months from the start of treatment. I took the drug for about six months. I also tried duoloxenta, but still returned to simbalta.

To prevent insomnia, the drug should be taken in the morning. It is better not to do this at night. Nevertheless, simbalta affects norepinephrine and this must be taken into account. Anxiety is removed in about 2-3 months, respectively, and panic attacks pass. Also a huge plus is that simbalta relieves pain. Many people prescribe it for pain, not depression. Tolerability was generally good. I’ve had worse antidepressants with a bunch of side effects.

Summing up, I can say that Cymbalta is a good and effective antidepressant. Side effects occur in the first weeks of treatment. When compared with other antidepressants that I drank, I can say that the side effects of simbalta are not the most harmless, but it happened worse. The drug works relatively quickly, which is a plus for me. Treats depression and gives energy. In addition, the drug effectively relieves pain. It is prescribed even for diabetes. There was no negative effect on weight. In fact, I did not see the difference between pure duloxetine and simbalta. The drug was satisfied.

The drug should be taken in consultation with the attending physician. Here I share my experience with Cymbalta, and this review is not a recommendation for treatment.

Cymbalta vs Effexor: Differences, Similarities and What’s Best for You – Drug Vs.

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Drug Overview and Key Differences | Conditions of treatment | Efficiency | Insurance coverage and cost comparison | Side effects | Drug Interactions | Warnings | Frequently Asked Questions

Cymbalta (duloxetine) and Effexor (venlafaxine) are brand name drugs used to treat mental illnesses such as depression and anxiety. They are commonly prescribed as antidepressants to relieve symptoms of major depressive disorder. Symptoms of major depressive disorder may include persistent sadness and a severe loss of interest in daily activities.

Cymbalta and Effexor belong to a class of drugs called serotonin and norepinephrine reuptake inhibitors (SNRIs). They work by increasing the availability of serotonin and norepinephrine in the brain. These chemicals, or neurotransmitters, are believed to play a role in causing mental disorders.

For the purposes of this comparison, the name Effexor may also refer to Effexor XR, the only Effexor brand currently available on the market.

What are the main differences between Cymbalta and Effexor?

Cymbalta

Cymbalta is the brand name for duloxetine. It is available as delayed-release oral capsules in 20mg, 30mg, or 60mg strengths. It is usually taken by mouth as one capsule once a day depending on the condition being treated. The maximum daily dose is 120 mg, although there is no evidence that doses greater than 60 mg provide a significant increase in benefit.

Cymbalta has a half-life of about 12 hours. It is metabolized and excreted through the liver and kidneys. It should be avoided in severe liver or kidney disease.

Effexor

Effexor is the brand name for venlafaxine. However, the brand name Effexor is only available as Effexor XR or venlafaxine extended release tablets. The immediate release effexor has been discontinued because it needs to be injected multiple times throughout the day and causes more nausea than the extended release version.

Effexor XR is available in 37.5 mg, 75 mg and 150 mg oral capsules. The dosage may vary depending on the condition being treated. However, Effexor XR is usually taken once a day with a target daily dose of 75 mg and a maximum daily dose of 225 mg.

Like Cymbalta, Effexor is metabolized in the liver and has a half-life of up to 11 hours. It can be used for liver or kidney problems at lower doses.

Conditions treated by Cymbalta and Effexor

Cymbalta approved by the FDA for the treatment of major depressive disorder (MDD) ) and generalized anxiety disorder (GAD). It can also be used to treat fibromyalgia and diabetic neuropathy pain, as well as general muscle, tendon, ligament and bone pain. Cymbalta may occasionally be used off-label for other anxiety disorders.

Effexor XR is FDA approved for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). It is also sometimes used off-label to treat obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and pain.

9014 8 yes

Are Cymbalta or Effexor more effective?

The effectiveness of Cymbalta or Effexor depends on the condition being treated. Very few studies have directly compared Cymbalta and Effexor. However, compared to placebo, Cymbalta and Effexor are more effective for conditions such as major depression.

One study combined several clinical trials and found venlafaxine to be a better short-term treatment option for major depression than duloxetine. Venlafaxine, the active ingredient in effexor, may also be preferred for those who do not respond well to initial treatment with selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants (TCAs). However, the study found that there were no significant differences in response and response rates between duloxetine and venlafaxine.

Another systematic review compared venlafaxine with duloxetine and other antidepressants such as paroxetine, fluoxetine and fluvoxamine. Compared to other options, venlafaxine was found to be one of the more effective antidepressants. However, both venlafaxine and duloxetine have been ranked among the least tolerated antidepressants in terms of side effects.

Consult with a mental health professional to determine the best treatment option for you.

Coverage and cost comparison of Cymbalta and Effexor

Cymbalta is a brand-name prescription drug used for depression. The generic duloxetine is usually covered by Medicare and insurance plans. With a 30-day supply, the average retail price can exceed $470. With the SingleCare Cymbalta coupon, the generic version starts at $15 at participating pharmacies.

Effexor XR tablets are available by prescription. Generic Effexor XR tablets are often covered by Medicare and insurance plans. At an average price of around $145, the Effexor XR is cheaper than the Cymbalta. However, using SingleCare’s Effexor XR Coupon can lower the cost even further. Ask a pharmacist for a generic and get it for about $15.

90 148 US$15+

Common side effects Cymbalta vs.

Effexor

The most common side effects of Cymbalta include nausea, headache, dry mouth, drowsiness or drowsiness, constipation and fatigue. Cymbalta may also cause diarrhea, decreased appetite, increased sweating, and abdominal pain, among other side effects.

The most common side effects of Effexor are nausea, headache, dry mouth, weakness and drowsiness. Effexor can also cause insomnia, constipation, dizziness, diarrhea, and decreased appetite.

Both Cymbalta and Effexor can also cause a decrease in sexual desire (libido). However, Effexor has been shown to cause more sexual dysfunction problems than Cymbalta.

The table below lists other common side effects of Cymbalta and Effexor.

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9014 8 1%

90 148 yes

*not reported 9011 4 Frequency not based on face-to-face trial data. This may not be a complete list of side effects that may occur. Please contact your doctor or health care provider for more information.
Source: DailyMed (Cymbalta), DailyMed (Effexor)

Cymbalta and Effexor drug interactions

Cymbalta and Effexor should not be used with monoamine oxidase inhibitors (MAOIs) such as selegiline and phenelzine. Cymbalta or Effexor should not be used within 14 days of stopping an MAOI. Otherwise, the risk of serotonin syndrome, a serious condition that may require emergency medical attention, increases.

There may also be a risk of serotonin syndrome when taking Cymbalta or Effexor together with another serotonergic drug. Serotonergic drugs include selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). Caution should be exercised when using serotonergic drugs with Cymbalta or Effexor.

Drugs such as paroxetine or fluoxetine may interfere with the metabolism of Cymbalta and increase its blood levels. This may lead to an increased risk of serious side effects when taking Cymbalta.

Cymbalta and Effexor should be used with caution or avoided with non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulants. Using these drugs together may increase your risk of bleeding.

9014 8 Selective serotonin reuptake inhibitors (SSRIs)

Talk to your doctor about other possible drug interactions.

Cymbalta and Effexor Warnings

Liver failure has been reported with Cymbalta. Those with a history of alcohol abuse or liver dysfunction should avoid taking Cymbalta. Cymbalta should be discontinued in those who develop signs of liver failure such as jaundice.

The use of Cymbalta or Effexor is associated with the risk of developing serotonin syndrome, which occurs when there is an excess of serotonin in the brain. Symptoms of serotonin syndrome may include palpitations, high blood pressure, sweating, tremors, and fever.

Cymbalta and Effexor may cause an increase in blood pressure. Patients with a history of high blood pressure should be monitored during treatment with Cymbalta or Effexor.

Cymbalta and Effexor should be used with caution in those with a history of bipolar disorder or seizures. These antidepressants can cause mania, hypomania, or seizures in some people.

Consult your physician for other possible warnings and precautions while using Cymbalta and Effexor.

Frequently asked questions about Cymbalta and Effexor

What is cymbalta?

Cymbalta is the brand name for duloxetine. It is used to treat major depression and anxiety disorders. It is also used to treat pain in diabetic neuropathy and fibromyalgia. Cymbalta is available in extended release capsules in doses of 20, 30, or 60 mg.

What is Effexor?

Effexor is the brand name for venlafaxine. It is used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. Regular Effexor has been discontinued; however, Effexor XR tablets are available in 37.5 mg, 75 mg, and 150 mg.

Are Cymbalta and Effexor the same thing?

Cymbalta and Effexor are serotonin and norepinephrine reuptake inhibitors (SNRIs). But they are not the same medicine. In addition to treating major depression and anxiety, Cymbalta is also FDA approved for treating certain types of nerve pain. On the other hand, Effexor is FDA approved for the treatment of panic attacks and social anxiety.

Cymbalta or Effexor is better?

The best antidepressant depends on the condition being treated and other medications the person may be taking. Venlafaxine may be a more effective short-term treatment option for depression. However, it may have a lower tolerance than Cymbalta in terms of side effects such as sexual dysfunction.

Can I use Cymbalta or Effexor while pregnant?

No conclusive studies have shown that Cymbalta or Effexor can be safe during pregnancy. An antidepressant should only be used during pregnancy if the benefit outweighs the potential risk. In some cases, it may be necessary to use Cymbalta or Effexor to control symptoms of depression during pregnancy. Talk to your doctor before using Cymbalta or Effexor during pregnancy.

Can I use Cymbalta or Effexor with alcohol?

Moderate drinking is probably safe when taking Cymbalta or Effexor. However, drinking alcohol at the beginning of treatment with Cymbalta or Effexor may lead to increased dizziness or drowsiness. It may be recommended to stop drinking alcohol for a few days after starting treatment.

Does Effexor affect memory?

There is no evidence that Effexor directly affects memory. Effexor XR is known to cause hyponatremia, or low blood sodium levels, especially if diuretics are also taken. Signs and symptoms of hyponatremia include headache, confusion, and memory impairment. Your doctor may recommend that you stop taking Effexor XR until the hyponatremia resolves.

What is a good alternative to Cymbalta?

Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Other SNRIs include Effexor (venlafaxine), Pristiq (desvenlafaxine), and Savella (milnacipran). Discuss your options for antidepressant treatment with your doctor.

How bad is Effexor withdrawal?

The dose of Effexor should be gradually reduced to prevent severe withdrawal symptoms. Abruptly stopping Effexor may result in symptoms such as nausea, dizziness, vomiting, nightmares, irritability and headaches.