What is Endocet 5/325. How does this medication work. What are the potential side effects and interactions. Who should not take Endocet 5/325. How to use this medication safely and effectively.

Composition and Purpose of Endocet 5/325

Endocet 5/325 is a combination medication containing two active ingredients: oxycodone (5 mg) and acetaminophen (325 mg). This powerful pain reliever is designed to address moderate to moderately severe pain, including conditions associated with fever. Let’s explore the roles of each component:

• Oxycodone: A narcotic analgesic belonging to the opioid class of medications
• Acetaminophen: An analgesic (pain reliever) and antipyretic (fever reducer)

Why combine these two medications? The synergistic effect of oxycodone and acetaminophen provides more effective pain relief than either component alone, allowing for lower doses of each ingredient and potentially reducing the risk of side effects.

Mechanism of Action: How Endocet 5/325 Works

Understanding how Endocet 5/325 functions in the body is crucial for appreciating its effectiveness and potential risks. The medication works through two distinct mechanisms:

Oxycodone’s Action

Oxycodone, an opioid, binds to specific receptors in the brain and spinal cord, altering the perception of pain and emotional response to it. This results in:

• Reduced pain signaling
• Increased pain tolerance
• Potential euphoric effects

Acetaminophen’s Role

While the exact mechanism of acetaminophen is not fully understood, it is believed to work by:

• Inhibiting prostaglandin synthesis in the central nervous system
• Modulating the body’s pain and temperature-regulating centers

This dual-action approach allows Endocet 5/325 to provide comprehensive pain relief for various conditions.

Proper Usage and Dosage Guidelines

Adhering to proper usage and dosage guidelines is essential for maximizing the benefits of Endocet 5/325 while minimizing potential risks. How should patients take this medication?

• Typical adult dose: One tablet every 6 hours as needed for pain
• Maximum duration: 7 days
• Administration: Swallow tablets whole with fluid; do not cut, break, crush, chew, or dissolve

Can the dosage be adjusted? The dosage may vary based on individual factors such as:

• Severity of pain
• Patient’s response to the medication
• Body weight
• Other medical conditions
• Concurrent medications

It’s crucial to use Endocet 5/325 at the lowest effective dose for the shortest duration possible to minimize the risk of dependence and other adverse effects. Always consult with a healthcare provider before altering the prescribed dosage.

Potential Side Effects and Risks

While Endocet 5/325 can be an effective pain management tool, it’s important to be aware of potential side effects and risks associated with its use. What are some common side effects patients might experience?

• Drowsiness and dizziness
• Constipation
• Nausea and vomiting
• Dry mouth
• Headache
• Itching

More serious side effects that require immediate medical attention include:

• Shallow or slowed breathing
• Confusion or severe drowsiness
• Seizures
• Unusual mood changes
• Signs of allergic reaction (rash, itching, swelling)

Are there long-term risks associated with Endocet 5/325 use? Prolonged use of this medication can lead to:

• Physical dependence and withdrawal symptoms upon discontinuation
• Tolerance, requiring higher doses for the same pain relief
• Increased risk of liver damage due to acetaminophen content
• Potential for opioid addiction

Drug Interactions and Precautions

Understanding potential drug interactions and necessary precautions is crucial for safe use of Endocet 5/325. What other medications or substances might interact with this drug?

• Other opioid medications
• Benzodiazepines and other CNS depressants
• Monoamine oxidase inhibitors (MAOIs)
• Certain antidepressants
• Alcohol

Patients should exercise caution and inform their healthcare provider if they are taking any of these substances. Additionally, certain medical conditions may increase the risk of adverse effects from Endocet 5/325, including:

• Liver or kidney disease
• Respiratory disorders
• History of substance abuse
• Head injuries or increased intracranial pressure
• Gastrointestinal conditions

It’s essential for patients to provide a comprehensive medical history to their healthcare provider before starting Endocet 5/325 to ensure safe and appropriate use.

Contraindications: Who Should Not Take Endocet 5/325

Certain individuals should not use Endocet 5/325 due to increased risk of severe adverse effects. Who falls into this category?

• Those allergic to oxycodone, acetaminophen, or any ingredients in the medication
• Individuals with severe liver dysfunction or active liver disease
• Patients with seizure disorders
• Those with pre-existing respiratory depression
• Individuals with status asthmaticus (unresponsive asthma)
• Pregnant or breastfeeding women
• Patients taking or who have recently taken MAO inhibitors
• Those with head injuries or brain tumors
• Individuals with acute alcoholism
• Patients with mild pain that can be managed with occasional use of over-the-counter pain medications
• Those with acute asthma or other obstructive airway diseases
• Individuals with cor pulmonale (heart failure caused by chronic high blood pressure in the lungs)
• Patients experiencing delirium tremens

It’s crucial for patients to disclose their full medical history and current medications to their healthcare provider to determine if Endocet 5/325 is appropriate and safe for their use.

Safe Storage and Disposal of Endocet 5/325

Proper storage and disposal of Endocet 5/325 are essential to prevent misuse, accidental ingestion, and environmental contamination. How should patients store this medication?

• Keep at room temperature
• Protect from light and moisture
• Store in a secure location out of reach of children and pets
• Keep in original labeled container

When it comes to disposal, what steps should patients take?

1. Do not flush medications down the toilet or sink
2. Do not dispose of in household garbage
3. Consult a pharmacist for proper disposal methods
4. Consider participating in medication take-back programs if available in your area

Proper storage and disposal not only ensure the medication’s effectiveness but also play a crucial role in preventing prescription drug abuse and environmental contamination.

Monitoring and Follow-up: Ensuring Safe Long-term Use

For patients prescribed Endocet 5/325, especially for extended periods, regular monitoring and follow-up are crucial. What aspects should healthcare providers and patients pay attention to?

• Effectiveness of pain relief
• Development of tolerance or dependence
• Presence and severity of side effects
• Changes in overall health status
• Liver function tests (due to acetaminophen content)

How often should patients follow up with their healthcare provider? This can vary based on individual circumstances, but generally:

• Initial follow-up within 1-2 weeks of starting treatment
• Regular check-ins every 1-3 months for long-term users
• Immediate consultation if experiencing severe side effects or changes in pain patterns

What signs indicate a need for dosage adjustment or discontinuation?

• Inadequate pain relief despite proper use
• Increasing tolerance requiring higher doses
• Persistent or severe side effects
• Signs of dependence or addictive behavior

Regular communication between patients and healthcare providers is key to ensuring the safe and effective use of Endocet 5/325 over time.

Alternative Pain Management Strategies

While Endocet 5/325 can be effective for managing moderate to severe pain, it’s important to consider alternative or complementary pain management strategies, especially for long-term pain conditions. What other options might patients explore?

Non-pharmacological Approaches

• Physical therapy and exercise
• Acupuncture
• Massage therapy
• Cognitive behavioral therapy
• Mindfulness and meditation techniques
• Heat or cold therapy

Alternative Medications

• Non-steroidal anti-inflammatory drugs (NSAIDs)
• Topical analgesics
• Antidepressants with pain-modulating properties
• Anticonvulsants for neuropathic pain

How can patients determine the best pain management strategy for their condition? It’s essential to work closely with healthcare providers to develop a comprehensive pain management plan that may include:

• Combination of pharmacological and non-pharmacological approaches
• Regular reassessment of pain levels and treatment efficacy
• Gradual tapering of opioid medications when appropriate
• Addressing underlying conditions contributing to pain

By exploring a range of pain management options, patients can often achieve better long-term outcomes and reduce reliance on opioid medications like Endocet 5/325.

Patient Education: Empowering Informed Decision-Making

Effective use of Endocet 5/325 relies heavily on patient education and informed decision-making. What key information should patients be aware of?

• Potential for dependence and addiction
• Importance of adhering to prescribed dosage
• Recognition of side effects and when to seek medical attention
• Safe storage and disposal practices
• Risks of combining with alcohol or other medications

How can healthcare providers effectively educate patients about Endocet 5/325?

• Provide clear, written instructions
• Discuss potential risks and benefits thoroughly
• Encourage open communication about concerns or side effects
• Offer resources for additional information and support

What role do patients play in their own education and safety?

• Ask questions and seek clarification when needed
• Report any changes in pain levels or side effects promptly
• Keep track of medication usage and effectiveness
• Inform all healthcare providers about Endocet 5/325 use

By fostering a collaborative approach to pain management, patients and healthcare providers can work together to ensure the safe and effective use of Endocet 5/325 while minimizing potential risks.

Legal and Regulatory Considerations

As a controlled substance, Endocet 5/325 is subject to various legal and regulatory requirements. What are some key considerations for patients and healthcare providers?

• Prescription requirements and limitations
• State and federal regulations on opioid prescribing
• Reporting obligations for suspected misuse or diversion
• Restrictions on refills and quantity limits

How do these regulations impact patient care?

• May require more frequent doctor visits for prescription renewals
• Potential for increased scrutiny of long-term opioid use
• Emphasis on exploring alternative pain management strategies
• Enhanced monitoring and documentation requirements

What responsibilities do patients have regarding the legal use of Endocet 5/325?

• Never sharing or selling prescribed medication
• Safeguarding medication to prevent theft or misuse
• Adhering to all terms of opioid treatment agreements
• Properly disposing of unused medication

Understanding and complying with these legal and regulatory aspects is crucial for both healthcare providers and patients to ensure appropriate use of Endocet 5/325 and contribute to broader efforts to address the opioid crisis.

Endocet – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

This combination product contains two medications: oxycodone and acetaminophen. Acetaminophen belongs to the group of medications called analgesics (pain relievers) and antipyretics (fever reducers). Oxycodone belongs to the group of medications called narcotic analgesics. Oxycodone – acetaminophen is used to relieve moderate to moderately severe pain, including conditions associated with fever. This medication should only be used when other non-narcotic pain medications are not effective or tolerated.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Endocet is no longer being manufactured for sale in Canada. For brands that may still be available, search under oxycodone – acetaminophen. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

How should I use this medication?

The dosage varies according to each individual and can be affected by the severity of the pain as well as each person’s response to the medication.

The usual recommended adult dose of oxycodone – acetaminophen (each tablet contains 5 mg oxycodone and 325 mg acetaminophen) is one tablet every 6 hours as needed for pain. This medication should be used at the lowest dose that provides pain relief for a maximum of 7 days.

Swallow the tablets whole with fluid. Do not cut, break, crush, chew, or dissolve the tablets. Doing so can result in dangerous adverse events, including death.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

This medication may be habit-forming if taken for long periods of time. Do not stop taking this medication without talking with your doctor. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

It is important to take this medication exactly as prescribed by your doctor. If your doctor has told you to take this medication on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

• are allergic to oxycodone, acetaminophen, or to any of the ingredients of the medication
• have severely decreased liver function or active liver disease
• have a seizure disorder
• have pre-existing respiratory depression
• have status asthmaticus (unresponsive asthma)
• are pregnant, breast-feeding, or in labour
• are taking or have taken (within the last 14 days) MAO inhibitors (e. g., phenelzine, tranylcypromine)
• have a head injury
• have a brain tumour
• have acute alcoholism
• have mild pain that can be controlled by occasional use of pain medications
• have acute asthma or other obstructive airway diseases (e.g., chronic bronchitis, emphysema)
• have cor pulmonale (heart failure caused by chronic high blood pressure in the arteries of the lungs)
• have delirium tremens (e.g., confusion, diarrhea, shaking, fever, hallucinations, disorientation) associated with alcohol withdrawal
• have increased cerebral spinal fluid pressure
• have increased levels of carbon dioxide in the blood
• have an abdominal condition that may require immediate surgery (e.g., appendicitis, pancreatitis)
• have or may have bowel or digestive system problems (e.g., paralytic ileus), or may have a blockage in the digestive system

What side effects are possible with this medication?

Many medications can cause side effects.  A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• constipation
• decreased ability or interest in sexual activity
• decreased coordination
• dizziness
• drowsiness
• headache
• itching
• lightheadedness or feeling faint
• nausea
• sweating
• vomiting
• weakness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred or double vision or other changes in vision
• difficulty sleeping
• dizziness when rising from a lying down or sitting position
• dry mouth
• fast, slow, or pounding heartbeat
• loss of appetite
• symptoms of withdrawal (e.g., nausea, vomiting, diarrhea, anxiety, shivering, cold and clammy skin, body aches, loss of appetite, sweating)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• convulsions (seizures)
• signs of a bowel blockage (abdominal pain, nausea, severe constipation)signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
• signs of breathing problems (e.g., shallow, irregular breathing, or slow or troubled breathing)
• signs of severe skin reactions (e. g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
• symptoms of overdose (e.g., cold, clammy skin, abnormally slow or weak breathing, severe dizziness, confusion, slow heartbeat, or extreme drowsiness)
• symptoms of serotonin syndrome (e.g., confusion, fast heartbeat, hallucinations, restlessness, shaking, shivering, sudden jerking of muscles, sweating)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

HEALTH CANADA ADVISORY

February 19, 2021

Health Canada has issued new restrictions concerning the use of acetaminophen. To read the full Health Canada Advisory, visit Health Canada’s web site at https://recalls-rappels.canada.ca/en/alert-recall/unintentional-exposure-young-children-adult-acetaminophen-tablets-may-pose-serious

Abdominal conditions: Oxycodone may make the diagnosis of abdominal conditions more difficult or it may worsen these conditions. People with abdominal conditions such as inflammatory or obstructive bowel disease, acute cholecystitis, or pancreatitis should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Accidental use: When oxycodone – acetaminophen is used by anyone other than the person for whom it was prescribed, the effects of the medication may be fatal. Children are especially at risk. Keep this medication out of sight and reach of children.

Alcohol and other medications that cause drowsiness: People taking this medication should not combine it with alcohol, and should avoid combining it with other medications that cause drowsiness or slow down your breathing (e.g., antidepressants, sleeping pills, anxiety medications). Doing so can cause additive drowsiness and reduced breathing, as well as other side effects, which can be dangerous and possibly fatal.

Breathing: Oxycodone can suppress breathing. People at risk for breathing difficulties, such as asthma, should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Dependence and withdrawal: This medication contains oxycodone. Physical dependence, psychological dependence, and abuse have occurred with the use of oxycodone. People with a history of past or current substance use problems may be at greater risk of developing abuse or addiction while taking this medication. Abuse is not a problem with people who require this medication for pain relief. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shaking, pain, nausea, tremors, diarrhea, and hallucinations. If you have been taking this medication for a while, it should be stopped gradually as directed by your doctor.

Drowsiness/reduced alertness: This medication may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.

Head injury: People with head injuries or increased pressure in the head may have a higher risk of experiencing side effects (breathing problems) or worsening of their condition while taking this medication. These people should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: Decreased kidney function can cause this medication to build up in the body, causing side effects. If you have kidney disease or reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: Acetaminophen can cause severe and potentially fatal liver damage. Acetaminophen is a common ingredient in many non-prescription medications for colds and flu, pain, arthritis, and fever. Check the product label on all the medications you are taking to make sure that you are not exceeding the recommended dose of acetaminophen. An overdose of acetaminophen can lead to potentially fatal liver damage.

Contact your doctor immediately if you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin.

Low blood pressure: This medication can make low blood pressure worse or cause low blood pressure, which may be severe. If you experience severe dizziness, especially when standing from a lying or sitting position, contact your doctor.

Other medical conditions: People about to undergo surgery of the biliary tract should use caution while taking oxycodone as it may worsen their condition. Oxycodone will worsen the effects of acute alcohol intoxication and delirium tremens.

As well, people with an irregular heart rhythm, low blood pressure, low thyroid (hypothyroidism), Addison’s disease, benign prostatic hypertrophy (enlarged prostate), urethral stricture, decreased function of the adrenal glands, or porphyria should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Seizures: This medication may cause seizures, especially when higher doses are used or when taken with other medications that may increase the risk of seizures. The risk of seizures is also higher for people with epilepsy, a history of seizures, or who are at risk of seizures (e.g., people with head trauma).

Serotonin Syndrome: Although rare, severe reactions are possible when oxycodone is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. These combinations should be avoided if possible. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible. 

If you are taking antidepressants, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who have taken oxycodone during pregnancy have been born with signs of narcotic withdrawal. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking oxycodone and acetaminophen, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using full-strength oxycodone – acetaminophen have not been established for children under 18 years of age.

Seniors: Seniors who take this medication may be more likely to experience side effects or worsening of preexisting medical conditions.

What other drugs could interact with this medication?

There may be an interaction between oxycodone – acetaminophen and any of the following:

• acetazolamide
• aclidinium
• alcohol
• amphetamines (e. g., dextroamphetamine, lisdexamfetamine)
• anesthetics
• antihistamines (e.g., bilastine, cetirizine, dimenhydrinate, diphenhydramine, hydroxyzine, rupatadine)
• antipsychotics (e.g., haloperidol, quetiapine, olanzapine, perphenazine, risperidone, thioridazine)
• aprepitant
• atropine
• azelastine
• “azole” antifungal medications (e.g., fluconazole, itraconazole, ketoconazole)
• barbiturates (e.g., butalbital, phenobarbital)
• benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
• benztropine
• bosentan
• brimonidine
• buprenorphine
• bupropion
• buspirone
• butorphanol
• cannabis
• chloral hydrate
• clidinium
• cobicistat
• conivaptan
• diuretics (e.g., amiloride, bumetanide, furosemide, hydrochlorothiazide)
• desmopressin
• diltiazem
• diphenoxylate
• disopyramide
• domperidone
• dronedarone
• efavirenz
• etravirine
• eluxadoline
• entacapone
• enzalutamide
• eplerenone
• esketamine
• fesoterodine
• flibanserin
• flunarizine
• glycopyrrolate
• grapefruit juice
• HIV protease inhibitors (e. g., darunavir, indinavir, lopinavir, ritonavir saquinavir)
• ipratropium
• isoniazid
• kava kava
• lemborexant
• letermovir
• lidocaine
• linezolid
• lithium
• macrolide antibiotics (e.g., clarithromycin, erythromycin,)
• methylene blue
• metoclopramide
• mifepristone
• mirabegron
• mirtazapine
• modafinil
• monoamine oxidase inhibitors (MAOIs; e.g., tranylcypromine, phenelzine, moclobemide, rasagiline, selegiline)
• muscle relaxants (e.g., baclofen, methocarbamol, orphenadrine)
• naltrexone
• other narcotic analgesics (e.g., fentanyl, codeine, morphine)
• oxybutynin
• pegvisomant
• phenylephrine
• pomalidomide
• pregabalin
• protein kinase inhibitors (e.g., ceritinib, crizotinib, dabrafenib, dasatinib, imatinib, nilotinib)
• quinidine
• rifabutin
• rifampin
• ropinirole
• rotigotine
• St. John’s wort
• scopolamine
• seizure medications (e.g., carbamazepine, felbamate, lamotrigine, levetiracetam, phenytoin, primidone, topiramate, vigabatrin)
• selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, sertraline)
• serotonin/norepinephrine reuptake inhibitors (e.g., desvenlafaxine, duloxetine, venlafaxine)
• sodium oxybate
• somatostatin analogues (e.g., lanreotide, octreotide, pasireotide)
• tetrabenazine
• tiotropium
• tizanidine
• trazodone
• tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine)
• tryptophan
• valerian
• verapamil
• warfarin
• zolpidem
• zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Endocet

Oxycodone: Uses, Interactions, Mechanism of Action

Tablet, extended release	Oral	5 mg
Tablet, extended release	Oral	20. 0 mg
Tablet, extended release	Oral	5.0 mg
Tablet, extended release	Oral	80.0 mg
Tablet, extended release	Oral	10 MG
Tablet, extended release	Oral	2.5 MG
Tablet, extended release	Oral	20 MG
Tablet, extended release	Oral	5 MG
Tablet	Oral	5 mg
Capsule, extended release	Oral
Tablet, effervescent	Oral
Tablet, extended release	Oral	10 mg
Tablet, extended release	Oral	20 mg
Tablet, extended release	Oral	40 mg
Solution	Intramuscular; Intravenous; Subcutaneous	10 mg
Solution	Intramuscular; Intravenous; Subcutaneous	20 mg
Injection, solution	Parenteral	10 MG/ML
Injection, solution	Parenteral	50 MG/ML
Tablet	Oral	7. 5 mg/1
Tablet, multilayer, extended release	Oral	20 mg
Tablet, extended release	Oral
Injection, solution	Parenteral
Tablet, extended release	Oral
Capsule	Oral
Capsule, gelatin coated	Oral
Tablet	Oral
Tablet, coated	Oral
Capsule	Oral	5 mg/1
Solution	Oral	100 mg/5mL
Solution	Oral	20 mg/1mL
Solution, concentrate	Oral	20 mg/1mL
Tablet	Oral	10 mg/1
Tablet	Oral	15 mg/1
Tablet	Oral	20 mg/1
Tablet	Oral	30 mg/1
Tablet	Oral	40 mg/1
Tablet	Oral	5 mg/1
Tablet	Oral	80 mg/1
Tablet, film coated, extended release	Oral	10 mg/1
Tablet, film coated, extended release	Oral	20 mg/1
Tablet, film coated, extended release	Oral	40 mg/1
Tablet, film coated, extended release	Oral	80 mg/1
Tablet, film coated	Oral
Tablet, extended release	Oral	10 mg/1
Tablet, extended release	Oral	20 mg/1
Tablet, extended release	Oral	40 mg/1
Tablet, extended release	Oral	80 mg/1
Injection, solution	Intravenous; Subcutaneous	10. 00 mg/mL
Tablet, film coated, extended release	Oral	15 mg/1
Tablet, film coated, extended release	Oral	160 mg/1
Tablet, film coated, extended release	Oral	30 mg/1
Tablet, film coated, extended release	Oral	60 mg/1
Tablet, film coated, extended release	Oral	10 mg
Tablet, film coated, extended release	Oral	40 mg
Tablet, film coated, extended release	Oral	5 mg
Tablet, film coated, extended release	Oral	80.00 mg
Tablet, delayed release	Oral	15 mg
Tablet, delayed release	Oral	30 mg
Tablet, delayed release	Oral	60 mg
Tablet, delayed release	Oral	80 mg
Tablet, film coated	Oral
Tablet, film coated, extended release	Oral	10. 0 mg
Tablet, film coated, extended release	Oral	20 mg
Tablet, film coated, extended release	Oral	60 mg
Tablet, film coated, extended release	Oral	80 mg
Solution	Oral
Tablet, extended release	Oral	120 MG
Tablet, extended release	Oral	15 mg
Tablet, extended release	Oral	30 mg
Tablet, extended release	Oral	60 mg
Injection
Solution
Solution; syrup	Oral
Capsule	Oral
Capsule	Oral	10 mg
Injection, solution	Intravenous; Subcutaneous
Capsule	Oral	20 mg
Capsule	Oral	5 mg
Solution	Oral	10 mg/ml
Solution, concentrate	Oral	10 mg/ml
Solution	Oral	1 mg/ml
Injection, solution	Intravenous	9 mg/ml
Solution	Oral	1 g
Solution	Oral	0. 1 g
Solution	Intravenous; Subcutaneous	9 mg
Tablet, extended release	Oral	80 mg
Solution	Oral
Concentrate	Oral	20 mg/1mL
Solution	Oral	5 mg/5mL
Tablet, coated	Oral	15 mg/1
Tablet, coated	Oral	30 mg/1
Tablet, coated	Oral	5 mg/1
Tablet	Oral	20 mg
Suppository	Rectal	10 mg
Tablet	Oral	10 mg
Suppository	Rectal	20 mg
Tablet, extended release	Oral	10 MG/5MG
Tablet, extended release	Oral	20 MG/10MG
Tablet, extended release	Oral	40 MG/20MG
Tablet, extended release	Oral	5 MG/2.5MG
Tablet, film coated, extended release	Oral	5 mg
Tablet, film coated, extended release	Oral	10 mg
Tablet, film coated, extended release	Oral	20 mg
Tablet, film coated, extended release	Oral	2. 5 mg
Tablet, film coated, extended release	Oral
Capsule, extended release	Oral
Capsule, extended release	Oral	13.5 mg/1
Capsule, extended release	Oral	18 mg/1
Capsule, extended release	Oral	27 mg/1
Capsule, extended release	Oral	36 mg/1
Capsule, extended release	Oral	9 mg/1

Endocet vs Percocet: Key Differences and Similarities – Drug Vs. Friend

Home >> Drug Vs. Friend >> Endocet vs Percocet: Key Differences and Similarities

Drug Vs. Friend

Endocet and Percocet are two brand names for a combination of acetaminophen and oxycodone. This combination drug is often prescribed for moderate to severe pain that is not relieved by other treatments.

Acetaminophen is a non-steroidal anti-inflammatory drug (NSAID) that relieves pain and inflammation by reducing the production of prostaglandins. Oxycodone is an opioid that binds to mu receptors in the brain. This combination provides a powerful pain reliever, relieving pain from injuries, surgeries, and other conditions.

Endocet

Endocet is available in doses of 325–2.5 mg, 325–5 mg, 325–7.5 mg, and 325–10 mg of acetaminophen and oxycodone. The usual dose of Endocet is administered every 6 hours as needed for pain. Common side effects of Endocet include constipation, nausea, and drowsiness.

Percocet

Percocet is available in 325–2.5 mg, 325–5 mg, 325–7.5 mg, and 325–10 mg of acetaminophen and oxycodone. Percocet can be taken every 6 hours as needed for pain, as directed by your doctor. Common Percocet side effects include constipation, nausea, and drowsiness.

Endocet and Percocet: a side-by-side comparison

Endocet and Percocet are identical medicines used for pain. Their characteristics can be found in the table below.

90 041

• Moderate to severe pain

90 041 Is this covered by insurance?

Endocet	Percocet
Moderate to severe pain
Drug classification
Opioid	Opioid
Manufacturer
Endo Pharmaceuticals	Endo Pharmaceuticals
General side effects
Constipation Drowsiness Dizziness Headache Nausea Vomiting Itching Lethargy Fatigue 9 0051	Constipation Drowsiness Dizziness Headache Nausea Vomiting Itching Lethargy Fatigue
Is there a common one?
Yes, acetaminophen/oxycodone	Yes, acetaminophen/oxycodone
Depends on your ISP	Depends on your ISP 34	Dosage forms
Oral tablet	Oral tablet
Average cash price
9 0048 $152 per shipment of 100 2. 5 mg capsules	$152 per shipment 100 capsules 2.5 mg
SingleCare discount price
Endocet price	Percocet price
Drug interactions
Alcohol SSRI/SNRI antidepressants Triptans CNS depressants (opioids, antihistamines, neuroleptics, sedatives, sleeping pills, antiemetics, phenothiazines, tranquilizers) Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine) Anticholinergics MAO inhibitors Tricyclic antidepressants CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole antifungals, protease inhibitors) 9004 9 CYP3A4 inducers (rifampicin, carbamazepine, phenytoin) Muscle relaxants Diuretics Oral contraceptives Beta-blockers (propranolol) Lamotrigine Probenecid	Alcohol SSRI/SNRI antidepressants Triptans CNS depressants emetics, phenothiazines, tranquilizers) Mixed agonist/antagonist analgesics (butorphanol, nalbuphine, pentazocine, buprenorphine) Anticholinergics MAO inhibitors Tricyclic antidepressants CYP3A4 and CYP2D6 inhibitors (macrolide antibiotics, azole antifungals, protease inhibitors) CYP3A4 inducers (rifampicin, carbamazepine, phenytoin) Muscle relaxants 9004 9 Diuretics Oral contraceptives Beta-blockers (propranolol) Lamotrigine Probenecid
Can I use if I am planning to become pregnant, pregnant or breastfeeding?
Endocet is pregnancy category C. Although side effects have been reported in animals, there have been insufficient studies in humans. Talk to your doctor about steps to take when planning a pregnancy. Endocet is not recommended while breastfeeding.	Percocet is Category C. in pregnancy. Although side effects have been reported in animals, there have not been enough studies in humans. Talk to your doctor about steps to take when planning a pregnancy. Percocet is not recommended while breastfeeding.

Summary

Endocet and Percocet contain the same active ingredients, acetaminophen and oxycodone. As a powerful opioid combination, Endocet and Percocet can help relieve moderate to severe pain.

Both Endocet and Percocet are available in the same dosage forms. They can be taken several times throughout the day as needed for pain relief. However, the maximum recommended daily dose of paracetamol is 4000 mg. This is because high doses of paracetamol can cause liver damage.