Can essential oils help manage multiple sclerosis symptoms. How do essential oils work for MS. Which essential oils are best for MS fatigue, pain, and cognitive issues. Are there any risks or side effects of using essential oils for MS.

Understanding Essential Oils and Their Potential Benefits for MS

Essential oils have gained popularity as natural remedies for various health conditions, including multiple sclerosis (MS). These concentrated plant extracts capture the essence and aroma of their source, offering potential therapeutic benefits. While scientific evidence is limited, some studies suggest that certain essential oils may help manage MS symptoms and associated conditions.

Common essential oils include:

• Chamomile
• Jasmine
• Lavender
• Lemon
• Peppermint
• Rose
• Sandalwood
• Tea tree

These oils are typically used in aromatherapy, a form of complementary medicine with ancient roots in Asian and Mediterranean cultures. While research on essential oils for MS is limited, some studies have shown promising results for managing symptoms like fatigue, anxiety, cognitive problems, and pain.

The Science Behind Essential Oils and Their Effects on MS Symptoms

Essential oils are believed to work by stimulating the limbic system, the part of the brain responsible for regulating mood, breathing, heart rate, and blood pressure. This interaction may contribute to their potential medicinal properties. But how exactly can essential oils impact MS symptoms?

Cognitive Function and Memory

A recent study published in the Journal of Medicine and Life found that lavender aromatherapy improved working memory in women with MS. This is particularly significant as cognitive changes, including memory problems, are common in MS patients. While these results are preliminary and require further validation, they offer hope for natural cognitive support.

Anxiety and Depression

Many MS patients experience anxiety and depression as co-occurring conditions. Essential oils like chamomile, jasmine, lavender, rose, and sandalwood are often used to calm nerves, relieve stress, and boost mood. A study published in Nursing in Critical Care demonstrated that lavender aromatherapy improved sleep quality and reduced anxiety in patients with coronary artery disease, suggesting potential benefits for MS patients with similar symptoms.

Pain Management

Pain is a common and often debilitating symptom of MS. Essential oils such as peppermint, lavender, frankincense, and vanilla have shown potential in alleviating various types of pain. A review published in the International Journal of Molecular Sciences highlighted the therapeutic potential of these oils for pain conditions, although most studies were conducted on animals rather than humans.

Popular Essential Oils for Managing MS Symptoms

While research specific to MS is limited, certain essential oils have shown promise in managing symptoms commonly associated with the condition. Here are some of the most popular options:

Lavender

Lavender is perhaps the most versatile essential oil for MS patients. Its potential benefits include:

• Improved memory and cognitive function
• Reduced anxiety and stress
• Better sleep quality
• Pain relief

Peppermint

Peppermint oil may help with:

• Pain management
• Improved focus and mental clarity
• Digestive issues

Frankincense

This ancient oil is believed to offer:

• Anti-inflammatory properties
• Pain relief
• Improved mood and reduced stress

Methods of Using Essential Oils for MS Symptom Relief

Essential oils can be used in various ways to potentially alleviate MS symptoms. It’s crucial to note that these oils should never be ingested, as this can be dangerous. Instead, consider the following methods:

Aromatherapy

Inhaling essential oil aromas is the most common and safest method. This can be done through:

• Diffusers
• Steam inhalation
• Inhaler sticks
• Adding a few drops to a tissue or cotton ball

Topical Application

Some essential oils can be applied to the skin when properly diluted with a carrier oil. Always perform a patch test first and consult with a healthcare professional. Topical applications include:

• Massage oils
• Lotions or creams
• Compresses

Bathing

Adding a few drops of essential oil to bathwater can provide a relaxing and potentially therapeutic experience. This method combines aromatherapy with the soothing effects of warm water.

Potential Risks and Side Effects of Essential Oils for MS Patients

While essential oils are natural products, they are not without risks. Dr. Vijayshree Yadav, a neurologist at Oregon Health and Science University, emphasizes that “natural doesn’t always mean safe.” Some potential concerns include:

• Skin irritation or allergic reactions
• Photosensitivity (increased sensitivity to sunlight)
• Interference with medications
• Respiratory issues in some individuals

It’s crucial to remember that the essential oil industry is largely unregulated, which can lead to inconsistencies in product quality and purity. Always purchase from reputable sources and consult with a healthcare professional before incorporating essential oils into your MS management routine.

Integrating Essential Oils into a Comprehensive MS Management Plan

While essential oils may offer potential benefits for MS symptom management, they should not be viewed as a standalone treatment. Instead, consider integrating them into a comprehensive MS management plan that includes:

• Conventional medical treatments prescribed by your neurologist
• A healthy diet rich in anti-inflammatory foods
• Regular exercise tailored to your abilities
• Stress management techniques like meditation or yoga
• Adequate rest and sleep

Mary Ellen Ciganovich, an author and educator specializing in holistic healing who has MS herself, shares her experience: “I handle my own MS through diet, exercise, meditation, herbs, and essential oils, and I recommend these approaches to others with the condition. Anything natural that helps keep my MS monster in its cave is very useful.”

Future Research and Developments in Essential Oils for MS

While current research on essential oils for MS is limited, the field shows promise for future developments. Areas of potential study include:

• Large-scale clinical trials to validate preliminary findings
• Investigation of specific essential oil compounds and their effects on MS pathology
• Development of standardized essential oil formulations for MS symptom management
• Exploration of synergistic effects between essential oils and conventional MS treatments

As research progresses, we may gain a clearer understanding of how essential oils can be effectively and safely integrated into MS care protocols.

Expert Opinions and Patient Experiences with Essential Oils for MS

While scientific evidence is still emerging, many MS patients and some healthcare professionals report positive experiences with essential oils. Dr. Yadav acknowledges the potential benefits but cautions against overgeneralization: “It’s a big leap to say that these oils work well in mice so they must work just as well in humans.”

Patient testimonials often highlight the holistic benefits of essential oils, citing improvements in mood, relaxation, and overall well-being. However, it’s important to remember that individual experiences can vary widely, and what works for one person may not work for another.

Seeking Professional Guidance

Before incorporating essential oils into your MS management routine, consult with your healthcare team. A qualified aromatherapist or naturopathic doctor with experience in MS care can provide personalized recommendations and help you navigate potential risks and benefits.

Complementary Therapies and Lifestyle Changes to Support MS Management

While essential oils may offer potential benefits, they are just one piece of the puzzle when it comes to comprehensive MS management. Other complementary therapies and lifestyle changes that may support MS patients include:

Acupuncture

Some MS patients report relief from pain and spasticity through acupuncture treatments. While research is limited, this ancient Chinese practice may offer benefits for some individuals.

Mindfulness and Meditation

Stress management is crucial for MS patients. Mindfulness techniques and meditation can help reduce stress, improve mood, and potentially alleviate some MS symptoms.

Nutrition and Dietary Supplements

A balanced diet rich in anti-inflammatory foods may help manage MS symptoms. Some patients also find benefits from supplements like vitamin D, omega-3 fatty acids, and turmeric, though it’s essential to consult with a healthcare provider before starting any new supplement regimen.

Physical Therapy and Exercise

Regular physical activity tailored to individual abilities can help maintain muscle strength, flexibility, and overall well-being. A physical therapist can develop a personalized exercise plan for MS patients.

Cognitive Behavioral Therapy (CBT)

CBT can be beneficial for managing the psychological impacts of MS, including depression and anxiety. This therapy can help patients develop coping strategies and improve overall quality of life.

The Importance of a Holistic Approach to MS Management

While essential oils and other complementary therapies may offer potential benefits, it’s crucial to maintain a holistic approach to MS management. This includes:

• Regular check-ups with your neurologist and healthcare team
• Adherence to prescribed medications and treatments
• Open communication about all therapies, including complementary approaches, with your healthcare providers
• Staying informed about the latest MS research and treatment options
• Participating in MS support groups or communities for emotional support and shared experiences

By combining conventional medical treatments with carefully selected complementary therapies like essential oils, MS patients may be able to achieve a more comprehensive and personalized approach to symptom management and overall well-being.

Conclusion: The Role of Essential Oils in MS Care

Essential oils offer a promising avenue for complementary care in MS management, with potential benefits for symptoms like fatigue, pain, anxiety, and cognitive issues. While research is still in its early stages, many patients report positive experiences with these natural remedies.

However, it’s crucial to approach essential oils with caution and under professional guidance. They should be viewed as a potential complement to, not a replacement for, conventional MS treatments. As research continues to evolve, we may gain a clearer understanding of how essential oils can be safely and effectively integrated into comprehensive MS care plans.

Ultimately, the journey with MS is unique for each individual. By working closely with healthcare providers and exploring various management strategies, including essential oils, patients can develop a personalized approach that addresses their specific needs and improves their quality of life.

Can Essential Oils Help Manage Multiple Sclerosis?

Essential oils are plant extracts designed to capture the “essence,” or scent, of the original plant.

Examples of popular essential oils include:

• Chamomile
• Jasmine
• Lavender
• Lemon
• Peppermint
• Rose
• Sandalwood
• Tea tree

These essences are typically compounded and sold as natural remedies for a variety of conditions. They are most often used in the practice of aromatherapy, which today is considered a form of complementary or alternative medicine with roots in ancient civilizations in Asia as well as in the Mediterranean region.

Scientific evidence for the medicinal benefits of these products is limited. But some studies have found they help manage fatigue, anxiety, cognitive problems, skin disorders, digestive problems, and headaches, among other symptoms.

Although little research has been done on the possible benefits of essential oils for multiple sclerosis (MS), one recent study suggests lavender may improve memory problems in people who have MS (these results are preliminary and moderate to low quality, and require additional studies and validation).

Others believe essential oils can help people with the condition manage pain, fatigue, and digestive problems, as well as other health conditions often linked with MS, like depression and anxiety.

“Anything natural that helps keep my MS monster in its cave is very useful,” says Mary Ellen Ciganovich, an author and educator who specializes in holistic healing and has MS herself. “I handle my own MS through diet, exercise, meditation, herbs, and essential oils, and I recommend these approaches to others with the condition.”

So how can essential oils help you — if at all?

What Are Essential Oils?

Essential oils are collected from the source plants through several processes, including distillation (using steam) or cold pressing. Once extracted from the plant, the oils are combined with a “carrier” oil to create the final product.

It’s important to note that essential oils aren’t intended to be taken orally. In fact, swallowing them may be dangerous.

Instead, they are designed to be inhaled or, in some cases, applied to your skin.

It’s believed that inhaling the aromas of essential oils can stimulate areas of your limbic system, the part of your brain that regulates mood as well as breathing, heart rate, and blood pressure.

The effect of essential oils on the limbic system is what gives them their medicinal qualities.

How Essential Oils Might Help Symptoms Related to MS

To date, the use of essential oils in the treatment of MS itself hasn’t been well studied, according to Vijayshree Yadav, MD, a neurologist at Oregon Health and Science University in Portland. But symptoms have been addressed in research.

A study published in the November–December 2021 Journal of Medicine and Life found that inhalation aromatherapy with lavender essential oil improved working memory in women with multiple sclerosis (this small study requires further validation through larger and higher-quality studies). Cognitive changes, including memory problems, are common in MS, according to the National Multiple Sclerosis Society (NMSS).

Essential oils may also treat other health problems often linked to MS.

For example, anxiety and depression are behavioral health conditions that are common in people with MS. Several essential oils — including chamomile, jasmine, lavender, rose, and sandalwood — are used to calm nerves, relieve stress, and boost mood.

A study of aromatherapy using lavender published in the March 2017 issue of the journal Nursing in Critical Care found that the essential oil improved sleep quality and reduced anxiety in people with coronary artery disease.

In addition, a review published in May 2017 in Frontiers in Aging Neuroscience suggested that aromatherapy with essential oils — including lavender and rosemary — improved cognitive function and slowed the progression of memory loss in people with Alzheimer’s disease and dementia. Cognitive function problems and memory loss are both symptoms of MS, although the underlying causes are not the same as in Alzheimer’s disease.

Pain, another common symptom of MS, may also be alleviated by essential oils such as peppermint, lavender, frankincense, and vanilla, among others. A review of existing research published in December 2017 in International Journal of Molecular Sciences found these oils and others have “therapeutic potential” for a variety of pain conditions.

But most of the studies included in the review involved the use of oils in animals as opposed to human participants.

“It’s a big leap to say that these oils work well in mice so they must work just as well in humans,” Dr. Yadav cautions.

What Are the Potential Downsides of Essential Oils?

Yadav emphasizes that “natural doesn’t always mean safe.” Essential oils are products of an unregulated industry, so the quality and composition of different brands and essences may vary, she says.

In general, it’s best to find an essential oil product that contains only the aromatic plant compound, with no additives or synthetic fragrances. Also, do your research and try to purchase products from a manufacturer with a reputation for quality and safety.

Although aromatherapy is generally safe for people, it may not be for pets. In addition, inhaling certain oils may be harmful for pregnant women and young children.

Finally, essentially oils applied directly to the skin have been known to cause allergic reactions, including rashes, breathing problems, and headaches.

“Don’t overdo it with essential oils, or any other natural remedy,” Ciganovich notes. “It’s important to use these products as directed and not use more, even if it’s working really well. These products, just like prescription meds, can have side effects, so begin slowly to see if they work for you. Also, don’t discontinue your other MS meds without consulting your doctor.”

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Multiple Sclerosis and Essential Oils: A Potential Natural Therapy

What is Multiple Sclerosis?

Multiple sclerosis (MS) is a lifelong autoimmune condition where the body mistakenly attacks a critical layer of cells surrounding and protecting the brain and the spinal cord. This sheath of cells is made of an unusual set of cells called oligodendrocytes. Sclerosis can be translated to lesions – multiple sclerosis, lots of lesions – and these lesions damage the sheath, meaning that it can no longer transmit messages as well as it should, so signaling is slowed or disrupted.

Multiple sclerosis is associated with symptoms varying from person to person but includes problems with arm or leg movement, sensation or balance, and vision. They can affect any part of the body.

The Main Symptoms Include:

• Muscle stiffness and spasms
• Difficulty walking and problems with balance and coordination
• Numbness or tingling in different parts of the body
• Problems with thinking, learning, and planning
• Vision problems, such as blurred vision
• Problems controlling the bladder
• Fatigue

These symptoms may come and go in phases or worsen over time, depending on your MS form.

The variation in the severity of symptoms is vast. Some people only have very mild symptoms, but it can cause severe debility for some. While MS is rarely fatal in its own right, complications like chest or bladder infections or swallowing difficulties can arise in severe MS. Aggressive multiple sclerosis life expectancies are around 5 to 10 years lower than average life expectancy would be. The gap is constantly reducing as new therapies and technologies are introduced.

Types of Multiple Sclerosis

Generally, MS begins in 1 of ways: these can manifest as one-off attacks, known as individual relapses (or exacerbations), or with a gradual progression of specific symptoms like numbness or pain in the limbs.

Relapsing-Remitting Ms

The vast majority of people diagnosed with MS have the relapsing-remitting type. This group will have episodes of new or worsening symptoms, known as relapses, that typically worsen over a few days; these episodes can last for days to weeks to months. Then, these slowly improve over similar periods, and the person will be said to be in remission when their symptoms are absent.

Around 80-90% of people diagnosed with MS have this form.

For these people, relapses will often occur without warning, and while there can sometimes be no apparent triggers, they can sometimes be associated with stress or periods of illness.

The symptoms may disappear with or without treatment, but some can persist. Further, a person with MS may experience repeated attacks of the same (or different) symptoms recurring over several years.

Periods of remission – times when symptoms are absent – can last for years at a time.

After many years (usually decades), about two-thirds of people with relapsing-remitting MS will develop secondary progressive MS. Rather than presenting as episodic attacks, symptoms of progressive MS gradually worsen over time. However, some people with this form will continue to have occasional relapses during this stage.

Primary Progressive MS

Between 1 and 2 in every 10 people with the condition start their MS with gradually worsening symptoms. This is known as Primary Progressive MS. Here, symptoms slowly worsen and accumulate over several years. There are no periods of remission. However, people often have periods when their condition stabilizes a little.

MS is one of the most common causes of disability in younger adults and is most commonly diagnosed in people in their 20s, 30s, and 40s, although it can develop at any age.

A Strange Correlation

An estimated 2.5k people in the world have multiple sclerosis. According to the Society, around 1 million are in the United States. 

The distribution of MS around the world is uneven. Generally, its prevalence increases the further north or south you journey away from the equator. Those parts of Asia, Africa, and America that lie close to the equator have deficient levels of MS, whereas Scotland and Canada have exceptionally high rates.

It is still unclear precisely what causes the body to attack itself in this way suddenly, but most experts believe it involves a combination of genetic and environmental factors.

It has been noted that certain ethnic groups have more resistance than others. The Sami or Lapps of northern Scandinavia and the Inuits in Canada have meager rates of MS, and similar patterns are observed amongst the Maoris of New Zealand.

Since multiple sclerosis is most prevalent in northern Europe, North America, Australia, and New Zealand, it has been suggested that it may have been carried around the world by European colonists and settlers and that the origins might be traceable to the Vikings and their colonization of parts of Northern Europe where MS is most pronounced. 

Do ‘Viking genes’ make people particularly susceptible to MS? 

It’s a compelling theory.

Similarly, it has been suggested that the gene pool may have widened as Scottish immigrants moved around the world (Scotland has much higher rates of multiple sclerosis than England or Wales).  

The Multiple Sclerosis Trust website has more about these exciting genetics theories.

Research suggests that the proportion of women with MS is increasing and is roughly 2 to 3 times more common in women than men.

Essential Oils for Multiple Sclerosis

Essential oils can be beneficial for managing symptoms of multiple sclerosis. There are two layers to this. The surface layer is that certain oils will help with fatigue, pain, etc., and are tremendously good for managing stress. 

But then, there is a deeper level, where researchers have observed how well certain oils improve symptoms and want to learn more about this, perhaps its functions, or to be able to verify precisely why this might be. 

So, it’s difficult to decide whether to list the oils I suggest and explain why they might be helpful or to go by symptoms. I will opt for the latter, but as such, you will find that oils like lavender (now one of the most well-researched essential oils for multiple sclerosis) keep popping up repeatedly.  

However, I’d like to begin unconventionally by talking about the neurotransmitter GABA, its associations with symptoms, and how aromatherapy can help overall. 

Understanding Essential Oils for Multiple Sclerosis Through its Actions on GABA 

Emotions, movement, and sensation are all governed by the nervous system.

Nerves transmit information from the limbs and organs back and forth through the brain. 

All nerves send messages via the spinal cord, except for the olfactory nerves, whose messages go straight to the brain. 

That last sentence was rich with information. 

The spinal cord is one of the areas affected by lesions. This is where messages become dysregulated because of lesions in the myelin. 

Olfactory nerves take messages about smells – which encompasses essential oils – to the brain via a less affected pathway. 

Anatomically, the nervous system is made of nerves sending electrical energy along them. The speed this energy moves along the nerves depends on the thickness of the surrounding myelin insulation.  

Information is passed from nerve to nerve at the synapse. 

Synapses are gaps between nerves. 

Consider it like when the baton is passed between two runners in a relay race.

Electrical messages cannot traverse the synaptic gap (or synaptic cleft), so the chemical nervous system takes over here. 

Chemicals called neurotransmitters feed information from nerve to nerve. 

You may have heard of the ordinary neurotransmitters serotonin, dopamine, and GABA…but there are many more…around a hundred, that we know o,f in total.

This synaptic gap is like a soup full of wonders, and the richness of the ingredients affects the nature of how we feel from day to day. 

For example, serotonin is involved in around 300 processes, from making sure our stools move through the body quickly to modulating our mood. Depression is associated with low levels of serotonin. However, it is unclear whether serotonin deficiency causes depression or depression causes the levels to drop.  

Either way, balanced levels are associated with feeling well. 

Central to well-being is the balance of GABA, the primary inhibitory neurotransmitter in the body. Instead of the word inhibitory, we could read calming. 

Dysfunctional levels of GABA are associated with stress, insomnia, anxiety, fear, pain, and sleeplessness. 

GABA is expressed by several different cells; significantly, in the case of this article, it is defined by immune cells and olfactory cells. 

That immune cells are connected with GABA also means that GABA also modulates inflammation. Therefore therapeutic strategies using GABAergic agents (agents that will affect GABA) are being explored as the possible next phase in multiple sclerosis treatments. 

In a recent rodent experiment, rats were chemically given encephalomyelitis to injure their brains; then, the researchers compared the differences between lots of GABA versus brains with deficient levels of it.  

The studies showed that GABA gave significant neuroprotection because it modulated the immune response, preventing the brain from becoming inflamed. Less inflammation meant less pain and other related symptoms. (Stamula, 2022)

Olfactory neurons also express GABA. 

In other words, when we smell calming things, our body makes calming neurotransmitters…

I mentioned lavender essential oil earlier, for example.

“Obvious…” you might say. And yes, it is, but bear in mind that all of those other aspects GABA influences- pain, memory, sleep -are all mediated through smelling calming things. 

Incidentally, the nervous system also expresses other neurotransmitters and neurohormones via olfaction—Serotonin, dopamine, oxytocin, nitric oxide, and estrogen…all influenced by various essential oils. 

So, next, I’d like to talk about the role of GABA in chronic pain conditions.

Why Inhaling Essential Oils for Multiple Sclerosis is So Powerful

Pain messages are transmitted to the brain through many mediums, and our perceptions of pain can, likewise, be affected by many things. For example, certain ethnicities experience pain more acutely than others, or being tired may make us feel like we are in more pain. Again, though, if we are distracted by something exciting, it’s often the case that we don’t even notice pain for a while. 

In short, the brain is a trickster. 

One of the main areas it can play tricks is through the actual nerves in the body itself. 

We’ve talked about this sheath of myelin that goes around nerves.

That’s oversimplified. 

Within each nerve are many bundles of fibers, and each one of those has its sheath. So rather than the image you might have that the nerve has myelin around the outside of it, there are many layers of it all butting up against each other right the way through the nerve. 

Easier to see how messaging can become confusing now.

They can be divided up into three groups based on their thicknesses. 

How fast it transmits messages is dictated by how much myelin there is insulating it. So loads of myelin should mean fast messaging, and less myelin should mean the messages naturally reach the brain a bit later. 

There is no reason to enter into the details of all the fibers here, only the ones with skinny myelin layers.  

These are known as C Fibers, 

Imagine if you have to burn your hand; these nerves keep reminding you afterward to be careful not to touch it again. (The others transmitted the immediate response to remove your hand from the heat and the Ouch, ow, ow…)

C fibers transmit a much longer, slower pulse that we experience as dull throbbing aches.

So the exciting thing about C-fibers is that they change shape. It has been recently discovered that they branch out and can act like a kissing gate based on the tone of the nervous system.

They can transmit to two different parts of the brain. 

(Incidentally, this is very useful to know people who have fibromyalgia and explains why sometimes they might feel pressure like a feather-like touch or when they have a flare up their pain levels can go off the charts.)

This transmission depends on how much GABA is in the system and also how many enkephalins are at the synapse. Enkephalins are like endorphins that exist within the spinal column and the brain. They are natural analgesics created when we exercise.

C Fibers open and close, branching out and changing direction based on how much GABA is in the system. 

With healthy levels of GABA, pain should be manageable. 

However, low levels of GABA mean that the C fibers that transmit low throbbing aches send information to a different part of the brain – a pain center- that always reads messages as pain, pain, pain.

As such then, stress management is vital. Keeping calmer can be achieved by inhaling essential oils (and using them topically for massage etc.), doing exercise and meditation, and other lifestyle therapies.

In these situations, sit and inhale the oil for 5 to 10 minutes daily. No great science is involved in that, simply contemplating music, reading a poem, or watching the telly—anything to keep the mind occupied and calm. I have several meditations on my YouTube channel that you could use if you wanted to.

The most calming essential oils for stress would be lavender, chamomile, geranium, rose, sandalwood crown, frankincense, vetiver, valerian, cedarwood patchouli, and palo santo.

One final point in this before we move on. Neurodegeneration is often first recognized in conditions like Parkinson’s and Alzheimer’s because the sense of smell weakens. This is because the cell turnover of olfactory neurons is so fast. So as the neurons deteriorate, they stop turning over so fast and begin to die off. 

Until recently, it had been thought this might not happen with MS because the sense of smell is rarely affected. However, recent data show that the same phenomenon occurs more slowly. As such, then, it’s the adage…use it, or lose it…the more you use them, the more vital that particular rain part should remain. 

Understanding the Essential Oils for Multiple Sclerosis

Lavender

Lavender has high levels of lineal acetate and linalool, which have proven analgesic properties. They are also proven to have anxiolytic and antidepressant qualities helping to balance mood.

Importantly, research shows that inhaling lavender reduces explicit fear of falling over in people with MS and improves balance by acting upon the proprioception centers of the brain. (Seddighi Kavidak 2022)

It is proven to alleviate feelings of MS fatigue (Motaghi, 2022) and improves working memory for patients with MS (Rezaie, 2021)

All the oils in this list will help you sleep, but lavender will always be on top of that list. 

Just a few notes on sleep because sleep difficulties are more common in MS than in the general population. This has many dimensions. The high prevalence of fatigue during relapses means you can often be more prone to napping. This can interrupt sleep patterns and make sleeping harder for some people. 

If you are taking corticosteroids to counter your symptoms of fatigue, these are stimulating and can make nighttime less restful. Other MS medications can also disturb sleep.

Naturally, on days when movement may be painful, or you feel exhausted, it makes sense to rest, but the less activity we do, the harder it is for us to sleep at night.  

Restless legs (use clary sage), pain, urinary or bowel symptoms, and hot flushes (Use a lavender hydrolat)… make sleep harder, as do stress, anxiety, and depression. 

Worry is the greatest of all the thieves of rest. 

Good quality sleep is vital to maintaining overall wellness anyway. Still, when you can’t get it, it adds to fatigue, memory, and pain.. Lack of restful sleep can cause daytime drowsiness and worsen some MS symptoms.

Lavender is soothing and is lovely used in massage or bath oils in particular.

Consider using lavender essential oil in a blender in a rollerball to use small amounts of pain daily.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Chamomile

When you are choosing essential oils for Multiple Sclerosis, I would be inclined to opt for Roman chamomile over German chamomile.

Roman chamomile essential oil is proven to have an anti-inflammatory nature. It’s calming to the spirit, which is tremendous for helping support during stressful times.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Geranium

The geranium essential oil supports healthy circulation and is wonderful for hormonal support, both of which can offer extra challenges on top of symptoms of Multiple Sclerosis.

It is soothing and calming and makes you feel like the world’s weight is drifting away when used in the bath.

Geranium is one of the most important oils for treating stress.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Frankincense

Frankincense essential oil slows the breath and restores elasticity to the tissues. It has anti-inflammatory properties and is wonderful for stiffness and difficulties with mobility.

Frankincense is tranquilizing by nature. It is sensitive and soothing and feels exceptionally calming when you’re frustrated.

It’s not accidental that frankincense is associated with churches and prayer since it brings a sense that God is closer to you and that your prayers may be answered.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Patchouli

Patchouli is extremely good for meditation because it moves the energy from the brain into the body. 

It eliminates all that frenetic thoughts coming and going and slows everything down. 

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Sandalwood

Again, very pacifying and slow, quiet and prayerlike.  

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Vetiver

The oil of tranquility. It feels like a heavy blanket is being laid over you.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Valerian

It smells like dirty older men’s feet, so blend it with something else, but there is no better oil if you are struggling to sleep or anxious. 

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Dealing with Pain Symptoms and Muscle Stiffness

To clarify…in the section, by all means, inhale these oils, but topical use and putting these essential oils for multiple sclerosis in the bath will probably be better here. 

Juniper

Super for removing toxins from the joints that occur from muscular overwork 

Safety: Not suitable for use during pregnancy or if you have a kidney disorder.

Yarrow

Also, its Latin name is Achillea millefolium. “Millefolium,” “thousand leaves,” referring to its feathery leaves. Achillea…named after the Greek Hero Achilles, who could only be harmed on his heel. His mother had fortified the rest of him after she dipped him in the River Styx.

Yarrow somehow speaks to particular vulnerabilities that won’t go away.

This blue oil contains azulenes which are like a liquid anesthetic.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Frankincense

For all the reasons listed above, it moves the focus from how relaxed and comforted it makes you feel to the physical aspect of elasticity. It’s a beautiful oil for stiffness.

Safety: Not suitable for use topically during the first 16 weeks of pregnancy.

Fatigue

I’d think citruses here: lemon, orange, grapefruit, mandarin…all those happy, positive, upbeat vibes.

Safety: None of the citrus oils are suitable for use topically during the first 16 weeks of pregnancy. Do not use grapefruit essential oil if you have platelet disorder or are on blood thinning medications. Also, never use old oils. This group is rich in monoterpenes, small molecules that oxidize quickly and can lead to skin sensitization.

Sweet Basil

If you’ve got severe “Don’t want to’s” (I have them most days!) Sweet Basil will counter that by kicking your ass just as hard. She’s all about “Quit thinking about it and just do it.”

Memory

Rosemary

So rosemary is both specific for nerve pain and good for memory.

Rosemary essential oil is proven to be an antidepressant, anxiolytic (works against anxiety), and antinociceptive (works against pain signaling). (Abdelhalim, 2015)

So really, rosemary is probably one of the most effective essential oils for multiple sclerosis…but she is also invigorating and stimulating.

Thus, you must use rosemary (and peppermint) reservedly and only in the morning. 

However, if you made yourself a blend of lavender, rosemary, and Basil to use each morning, you’d feel much brighter, more confident, and command of the day. 

Safety: Not suitable for use in the first 16 weeks of pregnancy. Neither would I recommend using this oil if you suffer from high blood pressure, epilepsy, or any psychosis-related condition.

Peppermint

Again, definitely a morning oil. Improves focus, concentration, and memory.

Very upbeat and in control.

Safety: Not suitable for use during the first 16 weeks of pregnancy or on children under 6.

Best Vitamins For Multiple Sclerosis

Sadly, no cure has been found for MS, although there have been dramatic improvements in treatment strategies over the last twenty years. Another area of particular interest is trying to influence the fats of the myelin sheath through vitamin therapies. 

Vitamin D

Vitamin D plays a role in regulating how cells called oligodendrocytes mature in the myelin sheath. It could be that vitamin D3 may encourage the sheath to regenerate new cells. Vitamin D may reduce inflammation, preventing further damage to the sheath.

As one might imagine, depression is a cozy bedfellow of MS, especially when repasses happen, and research suggests that vitamin D may also influence symptoms of depression.

As stated, vitamin D is believed to support healthy sleep.

Biotin 

This regulates how our body metabolizes and uses fats and makes them. Since myelin comprises mainly fat, researchers speculate there may be benefits to supplementing with Biotin. Biotin may activate the carboxylases that increase how much myelin is made and may also support its repair.

Additionally, Biotin may enhance the manufacture of adenosine triphosphate (ATP), which may prevent neurodegeneration.

It’s hard to know if this option is viable since studies are inconclusive.

Some people feel Biotin helps them, and studies show that the optimal treatment plan would be to take Biotin for 12-15 months (https://pubmed.ncbi.nlm.nih.gov/34332461/). However, others suggest their symptoms have worsened while they are taking Biotin.

An important consideration, if you are considering taking this supplement, is that the presence of Biotin in the bloodstream skews blood results, particularly thyroid labs.

Its presence can lead to misdiagnosis of conditions and interrupted treatment plans (Ylli, 2021). It is vitally important to discuss taking the supplement with your physician if you are considering it, so its effects can be gauged and accounted for holistically.

Omega 3

Supplementation of Omega-3 fatty acids is associated with enhanced quality of life for people living with MS, although the mechanisms of why remain unclear. 

This polyunsaturated fat contains two important anti-inflammatory compounds, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), also associated with improved brain function.

Additionally, Omega-3 is proven to raise “good” HDL cholesterol and lower triglycerides and harmful fats in the blood serum, which supports normal cardiac health.

Final Word

Like you, I look forward to the day a cure is found for MS. Until that time; I hope this research in the essential oils for multiple sclerosis proves helpful to you and helps to make your life easier, more restful, and enjoyable.

Identification of essential oils in lippia javanica

Introduction

As part of the implementation of the State Strategy for the Development of the Pharmaceutical Industry of the Russian Federation for the period up to 2030, the priority direction is the production of medicines, including those of plant origin. Interest in herbal medicines remains relevant today due to their mild action, low toxicity and the possibility of long-term use for the prevention and treatment of various diseases. With the development of science and medicine, more and more modern medicines are being created, but medicinal plants are still the main guarantor of the future in medicine and healthcare.

L. javanica is a perennial shrubby, herbaceous plant up to 4.5 m high with strong fragrant leaves that exude lemon flavor when crushed [15-17]. It occurs naturally in central, eastern and southern Africa. In southern Africa, this species grows in Botswana, Malawi, Mozambique, South Africa, Swaziland, Zambia, Zanzibar, and Zimbabwe [15–16].

For many years, the shrub has been used in medical practice in South Africa due to its rich chemical composition, which means it has a wide range of pharmacological activity. The main pharmacological effects include anti-inflammatory, antioxidant, anti-symplastic, anti-microbial, anti-tuberculosis and anti-viral effects, which will allow us to produce better and safer essential oils in the distant future [23-25].

Based on this, the shrub is used to treat a wide range of diseases [28-29]. According to various sources, it is used in the treatment of the following diseases and their symptoms (Table 1).

Table 1. List of diseases and methods of use Lippia Javanica

In medical practice

Based on the data in the table, it can be concluded that Lippia javanica is most often used in the treatment of otolaryngological and pulmonological diseases, which makes its long-term use in the medical field promising in the near future, including the receipt of new sprays and the production of new lozenges from cough, to help people.

Separately, it is worth noting the importance of drugs based on Lippia Javanica in the complex treatment of coronavirus infection (COVID-19). This plant has been widely used for many years in the treatment of infectious diseases, so it is not surprising that the local population of the South African region used essential oils, tinctures, inhalations and decoctions of Lippia Javanica for the prevention, and then in the complex therapy of new strains of COVID-19 [25] . From this it follows a simple conclusion that this medicinal plant opens the possibility for wider research, therefore, mass production of drugs against microbes and viruses will be launched in the near future, since the plant contains polyphenols and flavonoids, which have such effects.

The composition of essential oils varies considerably depending on the place of origin, harvest season and weather. The complex molecular composition of many essential oils requires high resolution separation in order to characterize the range of compounds that make up the oils. In addition, it is often necessary to study small differences between oils that correspond to differences in the geographic or genetic origin of the plant material.

Chromatography, especially gas chromatography (GC) and mass spectroscopy (MS), have been the most widely used analytical methods for analyzing essential oils. However, the limitations of GC and GC/MS have pushed chromatographers to search in depth for more efficient methods for analyzing essential oil volatiles, such as improved sample preparation prior to injection. The methods tested were steam distillation, dynamic headspace, static headspace and SPME (solid phase microextraction). As a result, the static headspace method (SPHX) is now the leading sampling method.

It is important to note that GC analysis of essential oils is usually done to evaluate a particular plant or herb for oil percentage and components. However, the analytical values ​​obtained in this way are not directly related to the volatiles in the herb itself, and may not correctly reflect the actual quality of the herb, depending on the isolation technique used. However, using a method such as the static headspace method in GC only allows you to get a profile of essential oils.

Mass spectrometry (MS) can be defined as the study of systems by the formation of gaseous ions with or without fragmentation, which are then characterized by mass-to-charge ratio (m/z) and relative amounts [41]. The analyte can be ionized thermally, by an electric field, or by exposure to high energy electrons, ions, or photons.

The last decade has seen a tremendous growth in the popularity of mass spectrometers as instruments for both standard analytical experiments and fundamental research. This is due to a number of features, including relatively low cost, simple design, and extremely high data acquisition rates. And, although the sample is destroyed by the mass spectrometer in the process, this method is very sensitive, and only a small amount of material is used in the analysis.

However, as is well known, compounds such as isomers can be misidentified by GC-MS analysis; this shortcoming is often observed in the analysis of essential oils. It is widely known that the composition of essential oils is mainly represented by terpenes, which give very similar mass spectra; therefore, a favorable match ratio is not sufficient for identification, and peak assignment becomes a difficult, if not impossible, task.

On the other hand, provided that the data contained in the mass spectrum libraries were recorded using genuine samples, it can be seen that the mass spectrum of a single terpene is usually sufficient to allow its identification in combination with the retention index obtained from methyl silicone stationary phases.

Materials and methods

The object of the study was the herb Lippia Javanica. To determine the optimal results, pharmacognostic analysis, macroscopic analysis, microscopic analysis, quantitative analysis of essential oil and its qualitative analysis were carried out. Determination of the essential oil content was carried out by steam distillation of Verbena Officinalis herb and Lippia Javanica herb followed by volume measurement. The mass fraction was expressed as a percentage of the ratio of mass to volume based on absolutely dry raw material or preparation. For the experiment, Method 2 of the RF Pharmacopoeia .1.5.3.0010.15 “Determination of the content of essential oil in medicinal plant raw materials and medicinal herbal preparations” was used. Materials used: distilled water, 10% sodium hydroxide solution, glycerin, essential oil measurement equipment, analytical balance, microscopy, Petri dishes. 50 grams of ground Verbena Officinalis and Lippia Javanica, respectively, were weighed on an analytical balance. The sample was placed in a round bottom flask, where 500 ml of distilled water was added. The steam distillation process of the essential oil took two hours.

All data were acquired using the following equipment:

– TriPlus 500 PF autosampler (Thermo Scientific)

– TRACE 1300 gas chromatograph (Thermo Scientific)

– MS detection with ISQ 7000 (Thermo Scientific) 90 005

– PC workstation with Chromeleon CDS ver. 7.2.10

– MS NIST Library 16

Separation was carried out on a capillary column TraceGold 5 30 m x 0.32 mm x 0.25 mm (Thermo Scientific) in a programmed temperature mode.

Headspace parameters:

GC parameters:

MS parameters:

Peak identification provided by NIST Library 16 MS.

Results and Discussions

The result of pharmacognostic analysis is represented by microscopic features, including stomata, etherovascular glands, and short simple unicellular hairs shown in fig. 1-3.

Qualitative analysis revealed the presence of essential oil in the herb L. javanica. The collected volume reached about 20 ml. It did not have a viscous and oily consistency; most likely, Lippia Javanica essential oils are thermolabile. The result was a watery liquid with a characteristic strong odor and taste, Figure 4.

Qualitative analysis for other active substances was carried out within 30 minutes. The following reagents were used: ammonia 10%, sodium hydroxide 10%, ammonium ferrous sulfate, sodium molybdate, ferric chloride.

Figure 2. Lippia Javanica raw material under the microscope (1 – Essential oil cavities)

glandular simple unicellular hairs).

Figure 4. Organoleptic testing of essential oils Lippia Javanica

A qualitative analysis of possible active compounds was also carried out. L. javanica showed flavonoids when reacted with 10% ammonia, a yellow color and a pale yellow color with 10% sodium hydroxide solution. Yellow coloration with iron and ammonium sulfate indicates the presence of tannins. Dark green staining with ferric chloride showed the presence of phenol and flavonoids in both plants. Lippia Javanica gave a pale red color with sodium molybdate indicating the presence of phenols.

Crude essential oil from Lippia Javanica was extracted by steam distillation. Crude oil was placed in a 20 ml tube and sealed. The total ion chromatogram (SIC) obtained under the above conditions is shown in fig. 1.

Signals of 54 components were registered on the chromatogram. Some of the peaks, especially at the end of the chromatogram, were identified as components of the stationary liquid phase. Most of the minor components are identified as esters of C4-C10 alcohols and C2-C5 acids, as well as benzoic acid. Several minor peaks have been identified as simple terpenes such as geraniol, pinene and cineole. The main components were identified as benzoic acid (peak at 7.298), phenylmethyl benzoate (peak at 15.671), ethyllinolaol (peak at 16.581) and its cis isomer (peak at 16.690), mequinol (peak at 18.093), piperonal (peak at 18.442), isocitroneol, and corimbolone (peaks at 22.827 and 23.300, respectively). ). The results of the search in the MS library are shown in fig. 2.

Conclusions.

The chemical classification of essential oils has been carried out. The features of the chemical structure, and physico-chemical properties of essential oils are described.

Lippia Javanica has been reported in the literature as being used as an additive to other medicines to fight the coronavirus (COVID-19) in the South African region.

This scientific study presents a method for determining the content of essential oil, describes its quantitative assessment and assessment of the quality of raw materials. The study is ideally suited for practical application and will help in the near future to expand the field of medicine and pharmaceuticals through the introduction of such essential oils, obtained in the cheapest and most effective ways.

The study takes into account the appearance, geographical distribution and habitats of Lippia Javanica containing essential oils. The idea is to import a medicinal plant from South Africa at a lower cost and produce more drugs here in the Russian Federation, or build a pharmaceutical manufacturing company in Zimbabwe to produce high quality and safe essential oils for the local population. It has been found that L. javanica contains higher quality essential oils, which gives a positive result in the development of the concept for the production of medicinal and cosmetic essential oils of higher quality and safety for the population.

Literature review and practice showed that L. javanica has heat labile essential oils, but they lack viscosity and oily consistency, and research will be done with another way to isolate heat labile essential oils. An alternative method can be used to develop the production of essential oils from Lippia javanica individually or through grants.

In addition, macro- and microscopic signs were taken into account, and all possible diagnostic signs for Lippia Javanica were confirmed. Qualitative analysis showed that L. javanica contains flavonoids, tannins, and phenols, which manifests itself as a pale red color when interacting with sodium molybdate.

In this regard, the composition of the essential oil of L. javanica was studied by PF-GC-MS, which showed that the essential oil is composed of more than 50 compounds of terpenes, ethers, aldehydes and aromatic acids.

Thus, Lippia Javanica can be introduced into medical practice as a source of essential oils and other phytochemicals due to its medicinal value. Research needs to be done and then patented or sold to major pharmaceutical companies so that they can produce more essential oils and other drugs such as NSAIDs[1] based on Lippia javanica.

[1] Nonsteroidal anti-inflammatory drugs

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Antifungal potential of Mentha piperita and Cinnamomum verum essential oils | Sharma

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