Exforge side effects: Side Effects of Exforge (Amlodipine and Valsartan), Warnings, Uses
Exforge HCT (amlodipine besilate/valsartan/hydrochlorothiazide) Drug / Medicine Information
5/160/12.5, 5/160/25, 10/160/12.5, 10/160/25, 10/320/25
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Exforge HCT.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
The information in this leaflet was last updated on the date listed on the final page.
More recent information on the medicine may be available.
You should ensure that you speak to your pharmacist or doctor to obtain the most up
to date information on the medicine. You can also download the most up to date leaflet
Those updates may contain important information about the medicine and its use of
which you should be aware.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What Exforge HCT is used for
Exforge HCT is used to control high blood pressure, also called hypertension.
Everybody has blood pressure. This pressure helps get your blood all around your body.
Your blood pressure may be different at different times of the day, depending on how
busy or worried you are. You have hypertension (high blood pressure) when your blood
pressure stays higher than is needed, even when you are calm and relaxed.
High blood pressure increases the workload of the heart and blood vessels. If it continues
for a long time, it can damage the blood vessels in the brain, heart and kidneys.
This can lead to stroke, heart failure or kidney failure. High blood pressure increases
the risk of heart attacks. Lowering your blood pressure reduces the chance of these
Exforge HCT contains amlodipine besilate, valsartan and hydrochlorothiazide. These
medicines reduce blood pressure in three different ways.
1. Amlodipine besilate blocks the movement of calcium into the cells of the heart and
blood vessels. As a result, they relax blood vessels and increase the supply of blood
and oxygen to the heart while reducing its workload.
2. Valsartan blocks the effect of angiotensin II, which is a substance in the body that
tightens blood vessels and makes your blood pressure rise. When the effect of angiotensin
II is blocked, your blood vessels relax and your blood pressure goes down.
3. Hydrochlorothiazide helps reduce the amount of excess fluid in the body by increasing
the amount of urine produced. This helps lower your blood pressure.
Ask your doctor if you have any questions about why this medicine has been prescribed
Your doctor may have prescribed it for another purpose.
There is not enough information to recommend the use of Exforge HCT in children.
This medicine is only available with a doctor’s prescription. It is not addictive.
Before you take Exforge HCT
When you must not take it
Do not take Exforge HCT if you have ever had an allergic reaction after taking:
amlodipine besilate, valsartan or hydrochlorothiazide (the active ingredients in Exforge
medicines belonging to a group of chemicals called dihydropyridines, used to treat
blood pressure and other heart problems
medicines belonging to a group of chemicals called sulfonamide-derived (such as some
antibiotics e.g. Bactrim trimethoprim and sulfamethoxazole)
any of the other ingredients listed at the end of this leaflet.
Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin.
Do not take Exforge HCT if you are pregnant or intend to become pregnant.
Exforge HCT is not recommended for use in pregnancy. Like other similar medicines,
it could affect your unborn baby.
Do not take Exforge HCT if you have any of the following medical conditions:
severe kidney disease or are having dialysis
severe liver disease including biliary cirrhosis
cholestasis, which is reduced or stopped bile flow
anuria, which is a condition where you are unable to urinate
high uric acid levels in the blood, which may cause gout
low level of potassium or sodium, or high level of calcium in your blood.
Check with your doctor if you are unsure if you have any of the above conditions.
Do not take Exforge HCT if you are also taking other blood pressure medicines containing
aliskiren and have type 2 diabetes.
Do not take Exforge HCT after the expiry date printed on the pack or if the packaging
is torn or shows signs of tampering.
In that case, return it to your pharmacist.
Before you start to take it
Tell your doctor if you have/have had any of the following health problems/medical
kidney problems or received a kidney transplant
systemic lupus erythematosus, a disease affecting the skin, joints and kidneys
heart problems, including obstructed blood flow from narrowing of valves (stenosis)
or enlarged septum (HOCM)
swelling, mainly of the face and throat, while taking other medicines (including an
ACE inhibitor or aliskiren)
a hormone disorder causing fluid retention known as primary hyperaldosteronism (Conn’s
passing less urine than is normal for you or difficulty passing urine
salt restricted diet
suffering from several episodes of vomiting or diarrhoea.
Your doctor may want to take special precautions if you have any of the above conditions.
Tell your doctor if you are breast-feeding a baby. Ask your doctor about the risks
and benefits of taking Exforge HCT in this case.
Hydrochlorothiazide and amlodipine are known to pass into the breast milk, however
it is not known if valsartan, the other active ingredient of Exforge HCT, passes into
the breast milk and could affect your baby. Therefore, Exforge HCT is not recommended
if you are breast-feeding.
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Your doctor will want to know if you are prone to allergies.
If you have not told your doctor about any of these things, tell him/her before you
take Exforge HCT.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including medicines
that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines and Exforge HCT may interfere with each other. These include:
medicines used to treat high blood pressure and some other heart conditions including
fluid tablets or diuretic medicines, ACE-inhibitors, aliskiren and beta blockers
simvastatin (a medicine used to help lower cholesterol levels), since the dose may
have to be reduced when taken with Exforge HCT
intravenous dantrolene used to treat malignant hyperthermia
some antibiotics (rifampicin), anti-rejection drugs (cyclosporin), antiretrovirals
(ritonavir) which may increase the effect of valsartan
tablets, preparations or supplements which increase the potassium levels in your blood
(such as certain types of diuretics, potassium supplements, salt substitutes etc.)
non-steroidal anti-inflammatory drugs (NSAIDs) and selective Cyclooxygenase-2 Inhibitors
(Cox-2 inhibitors), medicines used to relieve swelling and other symptoms of inflammation,
including arthritis (Your doctor may also check your kidney function)
medicines or supplements containing calcium
medicines used to relax muscles before or during surgery
steroid medicines such as cortisone, prednisone and ACTH
lithium, antidepressants, antipsychotics, medicines used to treat mood swings and
some types of depression
cyclophosphamide or methotrexate
amphotericin, a medicine used to treat fungal infections
insulin and tablets used to treat diabetes
medicines used to treat gout
carbamazepine, an anticonvulsant and mood stabilising drug used primarily in the treatment
of epilepsy and bipolar disorder
digoxin or other digitalis glycosides (medicines used to treat heart problems)
antiarrhythmics (medicines used to treat heart problems)
medicines used for oesophageal ulceration and inflammation
amantadine, and anti-Parkinson therapy also used to treat or prevent certain illnesses
caused by viruses
cytotoxic drugs used in cancer therapy
medicine used to treat gastrointestinal cramps, urinary bladder spasm, asthma, motion
sickness, muscular spasms, Parkinson’s disease and as aid to anaesthesia from a class
called anticholinergic agents
cholestyramine, colestipol, and other resins (medicines used mainly to treat high
levels of lipids in the blood)
pressor amines, such as noradrenaline (substances that raise blood pressure)
barbiturates, narcotics (medicines with sleep-inducing properties) and alcohol.
radioactive iodine, used as a medical tracer or diagnosis.
Your doctor and pharmacist have a more complete list of medicines to be careful of
while taking Exforge HCT.
How to take Exforge HCT
Follow carefully all directions given to you by your doctor and pharmacist.
These instructions may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist
How much to take
Your doctor will tell you how many tablets to take each day. The usual dose is one
tablet a day.
When to take it
Take your Exforge HCT dose at the same time each day.
This also helps you remember to take it, especially if you take it as part of your
usual routine (e.g. at breakfast time). This medicine will keep working for the whole
24 hours until the next dose is due.
How to take it
Swallow the tablet with a full glass of water.
Always take Exforge HCT in the same way, with or without food.
You can take it with or without food but it will work best if you always take it in
the same way every day.
How long to take it
Take this medicine until your doctor tells you to stop even if you feel quite well.
People who have high blood pressure often feel well and do not notice any signs of
If you forget to take it
If it is almost time for your next dose, skip the missed dose and take the next one
when you are meant to.
Otherwise, take the dose as soon as you remember and then go back to taking it as
you would normally.
Do not take a double dose to make up for the one that you missed.
This may increase the chance of side effects.
If you have trouble remembering when to take your medicine, ask your pharmacist for
If you take too much (Overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone number:
13 11 26) for advice, or go to Accident and Emergency at your nearest hospital if
you think that you or anyone else may have taken too much Exforge HCT. Do this even
if there are no signs of discomfort or poisoning.
Keep the telephone numbers for these places handy.
Too much Exforge HCT may make you feel dizzy, light headed or faint. You may experience
rapid, shallow breathing or cold, clammy skin. Your heartbeat may be faster than usual.
This is because your blood pressure is too low.
While you are taking Exforge HCT
Things you must do
If you become pregnant while taking Exforge HCT, tell your doctor immediately.
You should not take this medicine while you are pregnant.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Otherwise your doctor may think that it was not effective and change your treatment
Be sure to keep all of your doctor’s appointments so that your progress can be checked.
Do this even if you feel well.
People with high blood pressure often do not notice any signs of this problem. But
it is important to keep track of your progress. Your doctor will want to check your
blood pressure and your kidney and liver function from time to time.
If you are going to have surgery, tell your doctor and anaesthetist that you are taking
Exforge HCT may affect some medicines you receive during surgery.
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking Exforge HCT.
Tell any other doctor, dentist or pharmacist who treats you that you are taking Exforge
Things you must not do
Do not take Exforge HCT to treat any other complaints unless your doctor says you
Do not give this medicine to anyone else, even if their condition seems to be similar
Things to be careful of
Avoid eating grapefruit or drinking grapefruit juice.
Grapefruit juice can affect the metabolism of some medicines, including amlodipine.
Be careful driving, operating machinery or doing jobs that require you to be alert
while you are taking Exforge HCT until you know how it affects you.
This medicine can cause tiredness, sleepiness or dizziness in some people. If you
have these symptoms, do not drive or do anything else that could be dangerous.
If this medicine makes you feel dizzy or light-headed, be careful when getting up
from a sitting or lying position.
Dizziness can usually be prevented by getting up slowly and flexing leg muscles and
toes to get the blood flowing. When getting out of bed, dangle your legs over the
side for a minute or two before standing up.
When you are outdoors, wear protective clothing and use a factor 30 (or higher), water
Do not use a sunlamp.
This medicine may cause your skin to be much more sensitive to sunlight than it normally
Exposure to sunlight may cause a skin rash, itching, redness or severe sunburn. If
your skin does appear to be burning, tell your doctor.
Treatment with Exforge HCT, particularly long-term use with high doses, may increase
the risk of some types of skin and lip cancer (non-melanoma skin cancer).
Protect your skin from sun exposure and UV rays while taking Exforge HCT. Regularly
check your skin for any new lesions and promptly report any suspicious skin lesions
to your doctor.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Exforge HCT, even if you do not think it is connected with the medicine.
All medicines can have side effects. Sometimes they are serious, but most of the time
they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects. You may not experience any
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of these side effects and they worry you:
buzzing, whistling, ringing or other persistent noise in the ears
dizziness, spinning sensation, changes in vision, uncoordinated movements
dizziness on standing up, especially when getting up from a sitting or lying position
sleepiness, tiredness, weakness or difficulty sleeping
pain in the back or joints
muscle pain, muscle tenderness or weakness, cramps
runny nose or congested sinuses
dry cough, sore throat or hoarse voice
bleeding, tender or enlarged gums
indigestion, loss of appetite, stomach upset, pain, diarrhoea, constipation or wind
nausea (feeling sick) or vomiting
tingling or numbness in hands or feet
rash, redness, blistering or peeling of skin, itching
appearance of a lump or discoloured patch on the skin
lip cancer; the signs and symptoms include:
a sore that doesn’t heal or comes back after healing
pale white or yellow flat areas that look like scars
raised and scaly red patches
small, smooth and shiny lumps that are pearly white, pink or red
a pink growth with raised edges and indents in the centre
a growth that has small blood vessels on the surface.
feeling anxious or sad
problems with sexual function
breast enlargement in men
unusual hair loss or thinning
pain when passing urine, passing more urine than normal or frequent urge to urinate
redness and warm feeling of the face and/or neck
swelling of the ankles, feet, face or hands
unusual tiredness or weakness
feeling nervous, depressed or moody
distorted sense of taste
sensitivity to light
symptoms of sunburn which happens more quickly than normal
Tell your doctor immediately or go to Accident and Emergency at your nearest hospital
if you notice any of the following:
signs of allergy such as rash, itching or hives on the skin; swelling of the face,
lips, tongue or other parts of the body; shortness of breath, wheezing or troubled
feeling of fast or irregular heart beat (pounding, racing, skipping beats)
tiredness or lack of energy, being short of breath when exercising
bleeding or bruising more easily than normal
constant “flu-like” symptoms such as chills, fever, sore throat, aching joints, sores
in mouth, swollen glands
severe dizziness or fainting
stomach pain with nausea, vomiting, loss of appetite, feeling generally unwell, fever,
itching, yellowing of the skin and eyes, and dark coloured urine
signs of a serious skin reaction such as painful red areas, large blisters, peeling
of layers of skin, bleeding in the lips, eyes, mouth, nose or genitals. These signs
may be accompanied by fever and chills, aching muscles and feeling generally unwell
unusual bleeding or bruising under the skin
passing less urine than normal
decrease in vision or pain in your eyes due to high pressure.
Tell your doctor immediately if you notice any new skin or lip lesions during or after
treatment or if an existing lesion changes its appearance.
The above list includes serious side effects which may require medical attention.
These side effects do not occur frequently.
Tell your doctor if you notice anything else that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After taking Exforge HCT
Keep your tablets in the original container until it is time to take them.
Store them in a cool dry place below 30°C (room temperature).
Do not store Exforge HCT or any other medicine in the bathroom or near a sink.
Do not leave Exforge HCT in the car or on window sills.
Heat and dampness can destroy some medicines. Exforge HCT will keep well if it is
cool and dry.
Keep medicines where children cannot reach them.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
If your doctor tells you to stop taking Exforge HCT, or it has passed its expiry date,
ask your pharmacist what to do with any tablets that are left over.
What it looks like
Exforge HCT 5/160/12.5 (5 mg amlodipine, 160 mg valsartan and 12.5 mg hydrochlorothiazide)
tablets are white, ovaloid, biconvex with bevelled edge and imprinted with NVR on
one side and VCL on the other. Packs of 7’s and 28’s.
Exforge HCT 10/160/12.5 (10 mg amlodipine, 160 mg valsartan and 12.5 mg hydrochlorothiazide)
tablets are pale yellow, ovaloid, biconvex with bevelled edge and imprinted with NVR
on one side and VDL on the other. Packs of 7’s and 28’s.
Exforge HCT 5/160/25 (5 mg amlodipine, 160 mg valsartan and 25 mg hydrochlorothiazide)
tablets are yellow, ovaloid, biconvex with bevelled edge and imprinted with NVR on
one side and VEL on the other. Packs of 7’s and 28’s.
Exforge HCT 10/160/25 (10 mg amlodipine, 160 mg valsartan and 25 mg hydrochlorothiazide)
tablets are brown yellow, ovaloid, biconvex with bevelled edge and imprinted with
NVR on one side and VHL on the other. Packs of 7’s and 28’s.
Exforge HCT 10/320/25 (10 mg amlodipine, 320 mg valsartan and 25 mg hydrochlorothiazide)
tablets are brown yellow, ovaloid, biconvex with bevelled edge and imprinted with
NVR on one side and VFL on the other. Packs of 7’s and 28’s.
Exforge HCT tablets are non-divisible and cannot be divided into equal doses.
Exforge HCT tablets contain amlodipine besilate (5 mg or 10 mg), valsartan (160 mg
or 320 mg) and hydrochlorothiazide (12.5 mg or 25 mg) as the active ingredients.
The tablets contain the following inactive ingredients:
cellulose – microcrystalline
silica – colloidal anhydrous
talc – purified
Exforge HCT 5/160/12.5 tablets also contain:
Exforge HCT 5/160/25 and also contain:
iron oxide yellow.
Exforge HCT 10/160/12.5 tablets also contain:
iron oxide yellow
iron oxide red.
Exforge HCT 10/160/25 and 10/320/25 tablets also contain:
iron oxide yellow.
Exforge HCT is supplied in Australia by:
ABN 18 004 244 160
54 Waterloo Road
Macquarie Park NSW 2113
Telephone: 1 800 671 203.
Australian Registration Numbers:
Exforge HCT 5/160/12.5: AUST R 157954
Exforge HCT 5/160/25: AUST R 158162
Exforge HCT 10/160/12.5: AUST R 158164
Exforge HCT 10/160/25: AUST R 158166
Exforge HCT 10/320/25: AUST R 158168.
This leaflet was prepared in August 2019.
© Copyright 2019.
® = Registered Trademark.
Internal document code: exh050821c based on PI exh050821i
Valsartan: medicine to treat high blood pressure
It’s usual to take valsartan once or twice a day.
If you take valsartan once a day, your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take valsartan at any time of day. Try to take it at the same time every day.
You can take valsartan tablets with or without food. Swallow the tablets whole with a drink of water.
How much will I take?
The dose of valsartan you take depends on why you need the medicine. Take it as instructed by your doctor.
The usual dose for adults is:
- 80mg to 320mg once a day for high blood pressure
- 40mg to 160mg twice a day for heart failure
- 20mg to 160mg twice a day after a recent heart attack
The dose may be lower if you’ve recently lost body fluids (for example because you’ve been sick or have diarrhoea).
The dose for children depends on their weight. The usual dose for children is:
- 40mg to 80mg once a day (for children weighing 18kg to 35kg)
- 80mg to 160mg once a day (for children weighing 35kg to 80kg)
- 80mg to 320mg once a day (for children weighing 80kg and more)
Will my dose go up or down?
After a few weeks your doctor will check your blood pressure and ask you if you’re getting any side effects. You may also have blood tests to check how well your kidneys are working and the amount of potassium in your blood. Your doctor will then decide whether to change your dose of valsartan.
If valsartan doesn’t bring your blood pressure down, your doctor may want to increase the dose. If your blood pressure gets too low or you get side effects, your doctor may want to lower your dose of valsartan.
How to take it
You can take valsartan tablets with or without food. Swallow the tablets with a drink of water.
If you’re taking valsartan as a liquid, it will come with a plastic syringe or spoon to help you measure out the right dose. If you don’t have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount of medicine.
Some people take valsartan in combination with other medicines:
- with amlodipine (brand name Exforge) to treat high blood pressure
- with hydrochlorothiazide (brand name Co-Diovan) to treat high blood pressure
- with sacubitril (brand name Entresto) to treat a type of long-term heart failure
What if I get sick while I’m taking it?
If you get severe diarrhoea or vomiting for any reason, contact your doctor or a pharmacist. They’ll be able to advise you about what to do.
They may recommend that you stop taking valsartan until you’re better, and you’re able to eat and drink normally again.
What if I forget to take it?
If you miss a dose of valsartan, take it as soon as you remember, unless it’s almost time for your next dose. Do not take a double dose to make up for a forgotten one.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
What if I take too much?
If you take too many valsartan tablets by accident, contact your doctor or go to your nearest hospital A&E department straight away. An overdose of valsartan can cause dizziness, sleepiness and a pounding heartbeat.
The amount of valsartan that can lead to an overdose varies from person to person.
Valsartan Side Effects | Liver Damage, Tumors & Other Effects
Valsartan is a high blood pressure drug that is considered generally safe and tolerated better by patients than alternative treatments. Like any drug, however, it comes with side effects.
Some side effects of the blood pressure medication are more serious than others and require medical attention. Possible serious side effects include allergic reactions and rare instances of liver damage.
Less serious, but more common, side effects include headache and dizziness. The medication may also cause weight gain, and it poses a serious risk to the unborn if taken during pregnancy.
Cancer is not a known side effect of valsartan, but in July 2018 manufacturers issued a valsartan recall for some batches of medication contaminated with N-nitrosodimethylamine (NDMA) — a toxic chemical known to cause cancer and death in animals. NDMA may also cause liver damage in humans.
Suffering from liver damage, tumors or cancer after taking Valsartan?
Common Side Effects
Common side effects of valsartan are generally mild and brief. They don’t necessarily require patients to stop taking valsartan, which is sold under the Diovan brand name. In addition to side effects listed on the label, people also reported weight gain and hair loss after taking the drug.
The most common side effects of valsartan include:
Pain in the abdomen
Lower blood pressure
High blood potassium
Weight Gain Reports
Weight gain is not listed on the valsartan label as a side effect. But a study of FDA reports found incidents of weight gain among patients who took the drug. Weight gain was more pronounced for women 60 and older who took the drug for less than one month or between two and five years and also took the drug Lyrica and had high cholesterol or asthma. eHealthMe published the study online.
No Proven Link to Hair Loss
Hair loss is not among the side effects listed on valsartan’s label. A review of FDA reports found that out of more than 29,000 people reporting side effects while taking the drug, 297 people reported hair loss. It’s not clear whether those people might have experienced hair loss without taking the medication.
Serious Side Effects
The drug carries warnings about the potential for low blood pressure. If you also take water pills and are on a low-salt diet while taking the drug, you are most likely to develop low blood pressure.
The drug’s label warns health care providers to monitor kidney function and potassium in vulnerable patients. The medication has also been linked to rare instances of acute liver injury.
Valsartan is considered extremely dangerous to the unborn. Patients should not take the medication when they may be pregnant. The drug carries a black box warning against use during pregnancy.
Potentially serious side effects include:
- Allergic reactions
Acute liver injury
Low blood pressure
Reduced renal (kidney) function
Hyperkalemia (higher than normal potassium in the blood)
Patients taking the drug have reported renal (kidney) impairment to the FDA. For patients with kidney disease, this medication can make it worse. Symptoms of kidney impairment include unexplained weight gain and swelling in hands, feet or ankles.
The drug may increase the level of potassium in your blood. This risk is increased in people with heart failure and kidney problems.
The drug may cause serious allergic reactions. If you have trouble breathing, develop hives or if your tongue or throat swells, seek immediate medical help. In rare cases, some people suffered angioedema, or severe swelling beneath the skin’s surface.
Some patients who took valsartan and experienced angioedema had previously suffered the problem with other drugs, including ACE inhibitors. The drug’s label advises patients not to take it again if they had angioedema.
Pregnancy Side Effects
Women should not take valsartan if they are pregnant. It can cause injury or even death to a developing fetus when taken during the second and third trimesters of pregnancy, according to a black box warning on the drug’s label. You should stop taking the drug as soon as possible after you know you are pregnant.
Women who may be pregnant should not take valsartan.
It’s not known if valsartan passes through breast milk and harms infants. Because of this, you should talk to your doctor before breastfeeding.
The FDA has received reports of elevated liver enzymes and very rare reports of hepatitis in patients taking the drug. In clinical trials, patients treated with Diovan experienced occasional elevations of liver chemistries, according to the drug label. Three patients treated with valsartan stopped taking the drug because of elevated liver chemistries.
Sexual Function of ED Patients Improved
The FDA has received reports of impotence among patients taking valsartan. The drug label does not specify whether that impotence refers to erectile dysfunction. However, some studies have suggested that drugs in the same category may actually have a beneficial effect on the sexual function of patients with high blood pressure.
Erectile Dysfunction Study
Valsartan did not increase the risk of ED, and it improved sexual function in men with ED and hypertension.
Two studies found that the drug improved all aspects of sexual function, particularly erectile function. The Journal of Clinical Hypertension included the research in a January 2007 study.
The findings are significant because many patients won’t stay on their blood pressure drugs, fearing erectile dysfunction, researchers said.
One study of 2,202 patients with high blood pressure reported an increase of sexual activity for those taking valsartan compared to people using other drugs or no medications. Each patient filled out a questionnaire about their health and sex life during three visits to their doctor over a four-month period.
“Valsartan increases the rate of sexual intercourse per week, whereas conventional therapy affects sexual activity adversely,” researchers said in the 2003 study.
Another study of more than 3,500 patients found “valsartan therapy markedly reduced” erectile dysfunction. That study, originally published in Blood Pressure Supplement journal in 2003, found that the drug reduced ED by as much as 53 percent. Additionally, it improved “orgasmic function, intercourse and overall satisfaction.”
Please seek the advice of a medical professional before making health care decisions.
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Exforge – Overview
Exforge is a combination medication that is sometimes prescribed to people for the treatment of hypertension. People who might need an Exforge medication prescription, including Exforge HCT and Exforge generic tablets, can use Push Health to connect with a local medical provider who can prescribe Exforge when appropriate to do so.
What Is Exforge?
Exforge is a combination medication that consists of amlodipine (Norvasc) and valsartan (Diovan). In doing so, Exforge provides a dihydropyridine calcium channel blocker and an angiotensin II receptor blocker (ARB) which can be used in treating high blood pressure in some patients – particularly ones who are not well controlled on one medication only. Exforge exerts its antihypertensive effects through a mechanism of action involving reduction in peripheral vascular resistance through smooth muscle relaxation and through blocking angiotensin II. The combined effect of these two actions caused by Exforge medication use often reduces blood pressure to a greater degree when compared to using either drug alone.
Exforge – Dosage and Coupon
Exforge is typically available as Exforge 5/160 tablets, Exforge 10/160 tablets, Exforge 5/320 tablets and Exforge 10/320 tablets. Many patients are started at Exforge 5/160 although the determination of the best dosage to use depends on the prescribing medical provider and the health characteristics of the patient. Following oral administration of Exforge, both component drugs will have passed their elimination half-life within five days. The drug components of Exforge are eliminated via both the liver and the kidney. Exforge is a slightly expensive medication, costing approximately 70 cents per Exforge 5mg / 160 mg tablet at many pharmacies in the United States. For people paying for their Exforge medication, Exforge coupons can sometimes be found online or through other sources. Additionally, some insurance plans may cover costs associated with an Exforge medication prescription.
Can I Buy Exforge Online?
Exforge OTC is not available in the United States because Exforge is a prescription medication and requires a consultation with a licensed medical provider before it can be dispensed by a pharmacy. Prior to a consultation, one cannot just buy Exforge online, either. People who might need an Exforge prescription, however, can use Push Health to connect with a local medical provider who can prescribe Exforge medication, including Exforge HCT and Exforge generic tablets, when appropriate to do so.
Exforge – Side Effects
Exforge, like similar medications, can cause side effects when used. Side effects that can result from Exforge use include vertigo, edema, low blood pressure, dizziness and nasopharyngitis. Exforge should be titrated slowly in people with kidney or liver dysfunction. Drug-drug interactions can occur in selected cases while using Exforge. Exforge and alcohol should not be used together. People with a known hypersensitivity to Exforge or ingredients in the formulation should not take Exforge medication. Before using Exforge tablets, it is important to discuss concerns and possible side effects with a pharmacist and qualified medical practitioner.
More Exforge Information
Last updated May 28, 2021. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions.
Exforge HCT 10/320/25 | healthdirect
What it is used for
Exforge HCT is indicated ONLY as substitution therapy for the treatment of hypertension in patients whose blood pressure is already adequately controlled on the triple combination of amlodipine, valsartan and hydrochlorothiazide taken either as three single component formulations or as dual-component formulation with a single component formulation, all components at the same dose level. Treatment should not be initiated with these fixed-dose combinations (see DOSAGE AND ADMINISTRATION).
How to take it
The way to take this medicine is: Oral.
This medicine is taken by mouth.
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- Shelf lifetime is 2 Years.
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Always read the label. If symptoms persist see your healthcare professional.
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All medicines and poisons in Australia are categorised by how they are made available to the public. Medicines with a low safety risk are usually less tightly controlled than medicines with a higher safety risk. This system is called ‘scheduling’.
You can read more about the scheduling of medicines as well as the different scheduling categories on our Scheduling of medicines and poisons information page.
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Pregnant or planning a pregnancy?
For the active ingredient amlodipine + valsartan + hydrochlorothiazide
You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.
Consumer Medicines Information (CMI)
For side effects, taking other medicines and more
Print the CMI.
Reporting side effects
You can help ensure medicines are safe by reporting the side effects you experience.
You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems
Exforge (amlodipine, valsartan)
What is it used for?
- High blood pressure with no known cause (essential hypertension).
This combination of valsartan and amlodipine is used when blood pressure has not been lowered sufficiently by taking valsartan or amlodipine alone.
How does it work?
Exforge tablets contain two active ingredients, amlodipine and valsartan. Valsartan is a type of medicine called an angiotensin II receptor antagonist. Amlodipine is a type of medicine called a calcium-channel blocker. These are both medicines used to lower high blood pressure.
Valsartan works by preventing the action of a hormone in the body called angiotensin II. Angiotensin II normally acts on special receptors in the body, with two main results. It causes the peripheral blood vessels to narrow, and it also stimulates the production of another hormone called aldosterone. Aldosterone causes salt and water to be retained by the kidneys, which increases the volume of fluid in the blood vessels.
Valsartan blocks the receptors that angiotensin II acts on and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This helps lower blood pressure.
Amlodipine works by slowing the movement of calcium through the muscle cells that are found in the walls of blood vessels and heart. It does this by blocking ‘calcium channels’ in these muscle cells. Calcium is needed by muscle cells in order for them to contract, so by depriving them of calcium, amlodipine causes the muscle cells to relax. Amlodipine acts specifically on the muscle cells in the walls of arteries, causing them to relax. This allows the arteries in the body to widen.
The relaxing and widening of the small arteries in the body decreases the resistance that the heart has to push against in order to pump the blood around the body. This reduces the pressure within the blood vessels. Amlodipine can therefore be used to treat high blood pressure.
How do I take it?
- One Exforge tablet should be taken once a day, preferably at the same time each day.
- The tablets should be swallowed with a drink of water. They can be taken either with or without food.
- If you forget to take a dose don’t worry, just leave out that dose and take your next dose as usual. Don’t take a double dose to make up for a missed dose.
- Dizziness and weariness may occasionally occur during treatment with blood pressure lowering medicines. Dizziness can be relieved by lying down until the symptoms pass. You should take extra care performing potentially hazardous tasks such as driving or operating machinery until you know how this medicine affects you and you are sure you can perform these activities safely.
- Your blood pressure should be regularly monitored while you are taking this medicine.
- If you have any problems with your kidneys your kidney function and the amount of potassium in your blood should be regularly monitored while you are taking this medicine.
- People with high blood pressure caused by high levels of the hormone aldosterone (primary hyperaldosteronism) do not generally respond to this type of blood pressure lowering medicine, and it is not recommended for these people.
Use with caution in
- People over 65 years of age.
- Moderately decreased kidney function.
- People with narrowing of the arteries that supply blood to the kidneys (renal artery stenosis).
- People who have had a kidney transplant.
- Mild to moderately decreased liver function.
- People with a blockage of the bile ducts (biliary obstruction, eg due to gallstones).
- Heart failure.
- People with narrowing of the main artery that leaves the heart to supply blood to the body (aortic stenosis).
- Heart valve disease (mitral valve stenosis).
- People with low fluid volume or salt levels in the body, eg due to diuretic therapy, low-sodium diet, diarrhoea or vomiting.
- Hereditary blood disorders called porphyrias.
- People who have previously experienced an allergic reaction to a medicine that involved swelling of the lips, face, throat or tongue (angioedema).
Not to be used in
- People allergic to related calcium-channel blockers (dihydropyridines, eg nifedipine).
- People with very low blood pressure (hypotension).
- People with severely decreased liver function.
- People with a rare form of liver disease involving the bile ducts (biliary cirrhosis).
- People with failure of the normal flow of bile from the liver to the intestines (cholestasis).
- People with severely decreased kidney function or who are having kidney dialysis.
- A condition where the heart fails to maintain adequate circulation of blood (cardiogenic shock).
- People with significant narrowing of the main artery that leaves the heart to supply blood to the body (aortic stenosis).
- Heart disease characterised by thickening of the internal heart muscle and a blockage inside the heart (hypertrophic obstructive cardiomyopathy).
- People with unstable heart failure following a heart attack.
- Children or adolescents under the age of 18 years.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
- This medicine should not be used in pregnancy, particularly in the second and third trimesters, as it may be harmful to the unborn baby. Seek further medical advice from your doctor. If you get pregnant while taking this medicine, stop taking it and consult your doctor immediately.
- It is not known if valsartan and/or amlodipine pass into breast milk. This medicine should therefore not be used during breastfeeding. Mothers will need to either stop breastfeeding while taking this medicine, or not take this medicine. This will depend on how important the medicine is for treating the mother’s blood pressure. It is important to seek medical advice from your doctor.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Common (affect between 1 in 10 and 1 in 100 people)
- Excessive fluid retention in the body tissues, resulting in swelling (oedema).
- Swelling of feet or ankles (peripheral oedema).
- Weakness or loss of strength (asthenia).
- Hot flushes.
- Cold and flu like symptoms.
- Inflammation of the nose and throat, causing a blocked or runny nose and sore throat (nasopharyngitis).
- Decreased level of potassium in the blood (hypokalaemia).
Uncommon (affect between 1 in 100 and 1 in 1000 people)
- Pins and needles (paraesthesia).
- A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).
- Sensation of spinning (vertigo).
- Increased heart rate (tachycardia).
- Awareness of your heartbeat (palpitations).
- Pain in the muscles, joints or back.
- Skin reactions such as redness, rash.
- Disturbances of the gut such as nausea, vomiting, indigestion, diarrhoea, constipation, abdominal pain.
- Dry mouth.
- Loss of appetite.
- Raised level of calcium or uric acid in the blood (hypercalcaemia or hyperuricaemia).
- Raised levels of fats in the blood (hyperlipidaemia).
Rare (affect between 1 in 1000 and 1 in 10,000 people)
- Increased urinary frequency.
- Erectile dysfunction.
- Sensation of ringing, or other noise in the ears (tinnitus).
- Visual disturbances.
- Sensation of heaviness.
- Excessive sweating.
- Muscle spasms.
- Low blood pressure.
- Itchy skin.
The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.
This medicine is likely to have an additive effect with other medicines that decrease blood pressure, particularly medicines that are used to treat high blood pressure (antihypertensives). This may cause dizziness, which can usually be relieved by lying down until the symptoms pass. If you feel dizzy while taking this medicine in combination with other medicines that can lower blood pressure you should let your doctor know, as your doses may need adjusting. Other medicines that decrease blood pressure include the following:
- ACE inhibitors, eg enalapril
- alpha-blockers such as prazosin
- other angiotensin II receptor antagonists such as losartan
- antipsychotics such as chlorpromazine
- benzodiazepines, eg temazepam, diazepam
- beta-blockers such as propranolol
- other calcium-channel blockers such as verapamil, nifedipine
- diuretics, eg furosemide, bendroflumethiazide
- dopamine agonists, eg bromocriptine, apomorphine
- MAOI antidepressants, eg phenelzine
- nitrates, eg glyceryl trinitrate
Valsartan may increase the level of potassium in your blood. If this medicine is taken with other medicines that can increase blood potassium levels, this effect may be enhanced. Such medicines include those listed below. If any of these are used in combination with Exforge, the amount of potassium in your blood should be monitored:
- non-steroidal anti-inflammatory drugs, eg indometacin, diclofenac, ibuprofen
- potassium-sparing diuretics (eg spironolactone, triamterene, amiloride)
- potassium salts, eg potassium citrate for cystitis
- potassium supplements
- potassium-containing salt substitutes such as Lo-Salt
Valsartan may increase blood levels of the medicine lithium, and this medicine is therefore not recommended for people taking lithium. If it is necessary to take both, your doctor should carefully monitor your blood levels of lithium and you should let your doctor know if you experience any signs that your lithium level is increasing, for example, loss of appetite, diarrhoea, vomiting, blurred vision, muscle weakness, lack of co-ordination, drowsiness, tremor, unsteadiness, muscle twitching, ringing in the ears or confusion.
Amlodipine increases the blood level of the cholesterol-lowering medicine simvastatin and this could increase the chance of simvastatin having side effects on your muscles. Your dose of simvastatin should not be higher than 20mg daily if you are also taking Exforge.
The following medicines may increase the amount of amlodipine in your blood and this could increase the risk of its side effects:
- protease inhibitors for HIV infection, eg ritonavir, nelfinavir, saquinavir
If you take any of these with Exforge, you should tell your doctor if you feel dizzy or experience any other side effects, as the dose of your Exforge may need to be reduced.
The following medicines may decrease the amount of amlodipine in your blood and so could make it less effective. As a result, your doctor may need to prescribe you a higher dose of Exforge tablets if you are taking any of these:
- the herbal remedy St. John’s wort (Hypericum perforatum).
The following medicines may oppose the blood pressure lowering effect of this medicine:
- corticosteroids, such as dexamethasone or prednisolone
- oestrogens, such as those in the contraceptive pill
- regular use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, diclofenac or indomethacin (occasional painkilling doses are unlikely to have a significant effect).
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain both valsartan and amlodipine.
Diovan contains just valsartan.
Istin contains just amlodipine. Amlodipine tablets are also available as the generic medicine, ie without a brand name.
This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at piano.io
Buying Exforge – Brand & Generic Exforge Canada Drugs
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5 mg/160 mg
10 mg/160 mg
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Exforge (generic name: Amlodipine/Valsartan) is a drug which is prescribed for the treatment of high blood pressure, also known as hypertension. Valsartan is a diuretic which belongs to the group of drugs called angiotensin II receptor antagonists. Diuretics help to prevent the body from absorbing too much salt, which can cause fluid retention. Too much salt in the blood can cause high blood pressure, putting strain on the heart and increasing the risk of heart disease, heart attack and stroke. Amlodipine is a calcium channel blocker, and works by relaxing the muscles of the heart and blood vessels. Many patients with hypertension do not have any symptoms at all, which is why it has been dubbed ‘the silent killer’, it is therefore recommended that after age 60 you have your blood pressure checked on a regular basis – at least once every 6 months. Some people may experience symptoms such as dizziness and feelings of nausea. Exforge works by keeping the blood vessels from narrowing, meaning that blood pressure is kept at a lower level. Hypertension is more common in women than men and the risk increases with age.
Exforge Side Effects:
As with any drug, there may be side effects from taking Exforge including dizziness, sensation of spinning, cold symptoms such as stuffy/runny nose, sneezing and sore throat. More serious side effects may include feeling as though you might pass out, swelling in the hands or feet, rapid weight gain, fast or pounding heartbeat, jaundice (yellowing of the eyes and skin), chest pain, nausea, sweating and generally feeling ill. If you experience any side effects you must seek medical attention immediately for safety.
You should follow the instructions of the doctor who prescribed Exforge to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Exforge comes in tablet form. You should swallow Exforge whole with a glass of water. Do not crush or chew tablets as this may cause for too much of the drug to be released at once. Exforge should be stored at room temperature away from direct sunlight and heat.
If you are allergic to any of the ingredients of Exforge, you should avoid taking it and inform your doctor. You must consult your doctor if you have any pre-existing medical conditions including kidney or liver disease, congestive heart failure, angina, severe coronary artery disease, if you are experiencing vomiting or diarrhea or if you have suffered from a heart attack. You must consult your doctor if you are taking any other medications as they may interact with Exforge, including heart medications, potassium supplements, salt substitutes, diuretics and other medications that lower blood pressure. It is important that you inform your doctor if you are pregnant, planning to conceive or breastfeeding as Exforge may cause harm to unborn and new born babies. Do not drink alcohol while taking Exforge as this may increase the side effects of the drug. Do not use potassium supplements or salt substitutes while taking Exforge.
The content on this page has been supplied to canadadrugsonline.com by an independent third party contracted to provide information for our website. CanadaDrugsOnline relies on these third parties to create and maintain this information and cannot guarantee the medical efficacy, accuracy or reliability of the information that has been provided to us. If you require any advice or information about the drugs on this page, a medical condition or treatment advice, you should always speak to a health professional. Please note that not all products, including any referenced in this page, are shipped by our affiliated Canadian Pharmacy. We affiliate with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. The items in your order maybe shipped from any of the above jurisdictions. The products are sourced from various countries as well as those listed above. Rest assured, we only affiliate with our authorized dispensaries that procure product through reliable sources. All prices are in US dollars.
90,000 The first European country completely abandoned the AstraZeneca vaccine :: Society :: RBC
Denmark suspended use of the drug in March due to reports of blood clots in some vaccinated patients and several deaths.The country has now decided to exclude AstraZeneca from the vaccination program
Photo: Alessandro Garofalo / Reuters
Denmark has completely phased out the coronavirus vaccine developed by the British-Swedish pharmaceutical company AstraZeneca.This was reported by the country’s health department.
“According to our assessment, based on scientific findings, there is a real risk of serious side effects associated with the use of the vaccine <...>, so we decided to exclude it from our vaccination program,” said the head of the department Seren Brostrem.
The Danish authorities agree with the findings of the European Medicines Agency (EMA) that the benefits of the drug outweigh the potential risks, the management noted.At the same time, the department recalled the call of the European regulator during the vaccination campaign at the national level to separately take into account the situation in each country.
Thrombosis risk recognized as rare side effect of AstraZeneca vaccine
Denmark is thus the first European country to ban the use of the AstraZeneca vaccine for all population groups.
Botulinum facial therapy – prices for the procedure in St. Petersburg
Preparations for botulinum therapy
The most commonly used Botox is the trade name for a product manufactured by the American company Allergan. In recent years, the drug Dysport, produced by the French brand Ipsen, has become popular.
As part of Botox, onabotulinum toxin A is used, that is, botulinum toxin with associated proteins. Dysport is identical in composition, but the concentration of botulinum toxin in Dysport is several times lower.
At the cost of 1 unit of Botox, it is equal to 4 units of Dysport, but the final price of the procedure will be the same, since the concentration of botulinum toxin in the first preparation is higher. The doctor will select the most suitable remedy depending on the available indications and your individual characteristics.
The procedure is carried out in a few simple steps:
- The doctor cleanses the skin of cosmetics and impurities.
- The skin is treated with a disinfectant solution.At the request of the client, an anesthetic is applied.
- Marking is performed before injections.
- Injections are made directly.
- The skin is re-treated with a disinfectant solution.
The average time for performing a manipulation is about 20-40 minutes. The effect of the injections is enough for a period of 4 to 10 months. The duration of the results largely depends on the individual characteristics of the human body and the amount of the drug administered.The dosage is calculated individually, depending on the severity of the problem, the age of the patient and the desired effect.
It is mandatory to consult a cosmetologist before injections; if there are contraindications, the service is not performed. In this case, the specialist will select for you other cosmetic procedures that will be aimed at eliminating existing wrinkles.
It is recommended to stay upright for the first few hours.Do not touch the injection sites or massage them. You should also adhere to the following rules:
- Stop drinking alcohol for 1-2 days.
- During the week, do not expose your skin to heat, including excluding trips to the sauna and steam bath and solarium.
- During the rehabilitation period, refuse to visit the pool and swim in open water.
- Do not use decorative cosmetics at the injection sites, wait until the skin is completely healed.
- For 1-2 weeks, exclude peels, massage and various injection procedures.
After botulinum toxin injections, small marks, redness and bruising may remain on the skin. They go away on their own within 2-3 days. If this does not happen, then immediately consult a doctor.
Results of procedure
The effect is not immediately noticeable: the first results appear in 1-2 days, and the final ones – in about 10-12 days. In some cases, a correction is required 2 weeks after the procedure.
After the injections, the muscles of the face relax, which leads to the gradual disappearance of mimic wrinkles. With the correct introduction, the facial expressions of a person are completely preserved, the “mask” effect is not created.
The result after the first session lasts for 4-10 months, plus the fact that Botox and Dysport have a cumulative effect, therefore, with regular injections, you will need to do it less often.
90,000 What you need to know before being vaccinated against coronavirus: the epidemiologist answered the main questions
Social networks now have a sea of tips and life hacks and even more questions: how to properly prepare for vaccination against coronavirus? Violent disputes unfold, patients give advice to each other, but competent answers from specialists are sorely lacking.We collected urgent questions and asked them to one of the most authoritative experts – Deputy Director for Research of the Central Research Institute of Epidemiology of Rospotrebnadzor, Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences Alexander Gorelov.
1. Is it true that the day before the injection and immediately after the vaccination it would be good to drink antihistamines on drink? They are said to help reduce side effects such as fever, swelling and pain in the arm.
– Not just useless, but harmful advice! The experience of previous vaccinations shows that antihistamines are needed only for people who have an appropriate allergic history.They take these pills as directed by a doctor on a routine basis. For all others, these drugs are not indicated. Moreover, one recent large study showed that taking antihistamines “prophylactically” during vaccination slows down the immune response to the vaccine.
In a word, any medicine should be used according to indications, the expert emphasizes. If you do not have them, then there will be no benefit, and harm is possible.
2. If flu-like syndrome occurs after vaccination – fever, chills, headaches and muscle aches – what is the best way to relieve these symptoms?
– The best option is paracetamol.If you need a slightly stronger pain relieving effect, ibuprofen. In general, both of these drugs have anti-inflammatory and analgesic effects.
3. After the first dose of vaccination, I caught a cold. What to do?
– The allowable interval between two doses of anticoid vaccines is up to two months. In this case, the second vaccination can be no earlier than two weeks after suffering an acute respiratory illness (cold).
The fact is that after vaccination, a weakened infectious process takes place in the body.If a respiratory virus is added to this, the body has to overexert itself, choose what to fight with. Such overloads are best avoided.
Therefore, we recommend that you be especially careful about your health between vaccinations, minimize contacts, visit crowded places, use masks – after all, they protect not only from covid, but also from any ARVI.
4. If a person still did not save himself and after the first vaccination caught a coronavirus – what then?
– In this case, no second vaccination is given.I also want to remind you: the vaccine begins to give real protection on average 32-42 days after the first vaccination. Therefore, do not relax, take care of yourself from infection.
5. Are inflammations in the mouth, bleeding of the gums a contraindication for vaccination?
– This will not interfere with vaccination in any way. After all, the injection is done intramuscularly, only for children they begin to test the vaccine in the form of nasal drops (they can drain into the mouth, and then inflammation of the gums would play a role. – Ed.).
6. Many are worried: they need to have their teeth treated, but the dentist will have to remove the mask, the risk of contracting covid increases. Is it true that first you need to get vaccinated against coronavirus, albeit with aching teeth, and then treat them?
– This is the correct tactic – first get vaccinated, and then go to the dentist. A contraindication for vaccination can only be a strong inflammatory process in the oral cavity, which is accompanied by fever and other systemic problems.
7. Chronic gastritis, abdominal pain, other diseases of the gastrointestinal tract can be contraindications?
– People with any chronic illness need to be vaccinated first, as they are at increased risk of severe covid complications. But if you have an exacerbation, then it is better to treat it first, and after two weeks go for a vaccination.
8. A person has chronic rhinitis (runny nose, nasal congestion), and Sputnik V, as you know, can give a flu-like syndrome and further aggravate a runny nose.Then, to relieve swelling of the nasal mucosa, you may need a spray with corticosteroids – will its use interfere with the development of immunity?
– We know that only hormones (corticosteroids) that are taken as pills or injections reduce the effectiveness of vaccinations. Inhalation hormones and others that are used topically (for example, in the form of ointments) do not have a systemic effect on the body.
So that with an exacerbation of rhinitis after vaccination, you can safely use antihistamines and corticosteroids prescribed by your doctor intranasally (sprays and nasal drops).
9. Do I need to pass any tests or examinations before vaccination?
– No. The main thing is that on the day of vaccination you have an ordinary, normal state of health and not have any sensations of discomfort. Before vaccination, the patient is examined by a doctor, measures the pressure, checks the temperature, and the condition of the mucous membranes (nose, throat) – in order to exclude acute diseases.
10. If you are afraid of an injection, side effects of vaccination – can you take sedatives?
– Yes, of course.In addition, pressure can rise due to anxiety. Therefore, on the day of vaccination, I would recommend that you measure your blood pressure yourself in the morning. And if it is increased, take the appropriate drugs recommended by your doctor.
11. I was allergic to some medications – can I get vaccinated against covid?
– Be sure to inform your doctor before vaccination. Depending on the medicinal components to which you were allergic, your doctor may recommend one or another vaccine – they have a different composition.
12. Do I need to get tested for antibodies after vaccination?
– I would say: it is possible, but not necessary. The level of antibodies is measured for population, epidemiological studies – to understand which part of the population has developed herd immunity. If you are personally very interested in the level of antibodies, you can take an analysis, but this will not be indicative. Over time, this level in any case drops, but all the same, cellular immunity remains, which will provide protection.
TELEPHONE TO CALL THE VETERINARY DOCTOR FOR STERILIZATION OF THE CAT – +7 (812) -903-97-27
Type of sterilization
Sterilization of a cat “Economy” (arrival, domestic anesthesia, removal of ovaries, consultation on feeding and maintenance)
Sterilization of a cat “Classic” (arrival, import anesthesia, removal of the ovaries and uterus, intradermal cosmetic suture, consultation on feeding and maintenance)
Sterilization of a “VIP” cat (arrival, import anesthesia, removal of the ovaries and uterus, intradermal cosmetic suture, consultation on feeding and maintenance, anti-sedan or dropper for quick awakening of the pet)
Existing diseases such as ovarian cysts, uterine inflammation (pyometra) and cancers can be prevented by spaying the animal.Many of the above diseases can lead to the death of the animal.
Pros and cons of neutering cats.
Despite the widespread belief that these procedures are not entirely humane in relation to animals, they are necessary to maintain the health of animals, especially those living in city apartments. Here’s why:
A neutered cat does not bring kittens. If it is not possible to regularly give kittens into good hands, spaying a mother is much more humane than regularly killing them or throwing them out into the street.
Sterilized cats stop marking territory to attract the opposite sex.
They do not have leaks and rutters, so they do not suffer from unsatisfied desires and do not feel like being in solitary confinement in a prison.
Sterilized animals are much easier and happier to endure being in a closed room in an apartment.
Sterilization does not distort the hormonal background of the animal, in contrast to the means of temporary contraception (drops, pills, etc.), which introduce a complete imbalance in the animal’s body.
After castration, the role of the ovaries is partially performed by the adrenal glands, due to which the animal remains healthy and almost complete.
Before castration, the cat’s body is fully tuned to active reproduction, competition and search for a mate; after the procedure, the life of the animal becomes calmer, but it finds many other activities to its liking and in most cases does not lose its hunting instinct.
TELEPHONE TO CALL THE VETERINARY DOCTOR FOR STERILIZATION OF THE CAT – +7 (812) -903-97-27
However, like any intervention in the affairs of nature, neutering cats has its own side effects:
The animal becomes more lazy, which makes it fat and begins to suffer from obesity.To avoid this, you need to maintain a specific diet and try to select a diet specially designed for neutered cats. In some cases, an initially lazy cat, after castration, begins to behave the other way around, like a kitten.
Obesity-related cardiovascular disease risk.
The risk of developing urolithiasis, which can be excluded with proper nutrition and taking special dietary supplements developed for castrated animals.
Few have heard that feline ovaries are a regenerating organ and if you leave a few cells, the animal can begin to reproduce some time after the operation and bring unexpected offspring, which happens quite often.
The most serious risk is anesthesia. Many cats are very sensitive to it and then get sick for a long time or may not bear it at all. This is due to the fact that such drugs for animals are not tested as thoroughly as for humans and there is a risk of getting a poor-quality injection or an incorrectly calculated dose. Therefore, for the operation, it is imperative to find a good veterinarian and a reliable veterinary service.
How the sterilization procedure is carried out.
Sterilization is an operation.In cats, the sterilization procedure is an intracavitary operation, which takes place either by completely opening the animal along the “white line” of the abdomen, or using laparoscopy. Laparoscopy is a modern method of performing intracavitary operations through a small incision in the side, more expensive and painstaking, but allowing the body to regenerate much faster and significantly reducing the risk of complications after surgery.
When is the best time to neuter your cat.
Veterinarians of the “Miravet” service recommend sterilization at the age of 9-12 months, during this period cats are easier to tolerate anesthesia and recover faster.This operation, if indicated, can be performed at a later age. The operation is abdominal, everything takes place under general anesthesia; in the postoperative period (10 days), special attention should be paid to the cat.
Preparing the cat for neutering.
Set the date of the operation so that it is somewhere in the middle between preventive vaccinations, or at least a couple of months before or after they are carried out. You can not feed the animal for 12 hours and drink for 2-3 hours before the operation.The cat should prepare a special place in advance where it will come to its senses after the operation and where the risk of infection of the suture will be minimized. For cats, it is necessary to prepare a couple of postoperative blankets in advance: one will be in the wash and ironing, and the second directly on the animal. It is very important that the blankets are perfect in size, do not have too long strings and are changed about a couple of times a day.
Postoperative care for cats.
After the operation, it is necessary to constantly monitor the condition of the pet, especially on the first day after the operation, for which someone from the family needs a day off.You should not trust this child, since in case of complications he will not be able to provide proper assistance, and the unforeseen death of a pet can cause moral injury.
Do not lay the animal on elevated objects and allow it to climb onto any furniture, because after the operation it has poor coordination, and the pet can easily get a fracture. You should put a clean tray without filler near the animal and in no case scold him for the fact that the pussy will go in the wrong place in the first days after the operation.
Usually cats wake up from anesthesia in 2-3 hours or longer, depending on the drug used, it is imperative to check this with the veterinarian. Immediately after waking up, you need to give a little water from a pipette in the amount necessary to wet the mucous membrane. You can drink it a couple of hours after waking up, and feed it a little with light and preferably liquid food that does not cause gas formation and constipation – after 6 hours, but you can wait longer.
In no case should you give water and especially feed an animal if its legs are twisted and its head sways violently: it may choke.This risk cannot be ignored, because after the operation, the animal physically cannot cough up – it is too painful, and the cat has not yet had time to heal and restore its abdominal muscle function. In the subsequent period of rehabilitation, it is worth feeding with semi-liquid and very soft food, and soaking dry food. Your veterinarian may recommend a specific diet.
Until the stitches have healed, it is worth paying special attention to the hygiene of the animal in order to avoid various inflammations and suppurations. The rehabilitation period lasts 10-15 days.
How to feed sterilized cats.
After a course of rehabilitation, the animal can eat anything, but in order to eliminate the side effects of castration described above, it is better to choose a special diet or a premium food complex designed for castrated animals. Food restrictions are the same as for non-castrated foods: spicy, salty, spices, fatty, fried and other unhealthy foods. It is recommended to give fish no more than 1 time a week, but only boiled and with selected bones.
It should be remembered that it is necessary to monitor the health of the pet and regularly show it to the veterinarian, regardless of whether it is neutered or not.
In the veterinary service “Miravet” you can order a service at home, the doctor will operate on the animal, apply an intradermal suture, inject drugs that accelerate the recovery from anesthesia, advise on changing the pet’s diet, care and maintenance after the operation.
Prices for sterilization of cats
Type of sterilization
Sterilization of a cat “Economy” (arrival, domestic anesthesia, removal of ovaries, consultation on feeding and maintenance)
Sterilization of a cat “Classic” (arrival, import anesthesia, removal of the ovaries and uterus, consultation on feeding and maintenance)
Sterilization of a “VIP” cat (arrival, import anesthesia, removal of the ovaries, consultation on feeding and maintenance, anti-sedan or drip for quick waking up of the pet)
GKB №31 – Ligation of internal hemorrhoids: methods, features
Briefly about the main points
Ligation of hemorrhoids with latex rings is a minimally invasive non-surgical method, the mechanism of action of which consists in mechanical clamping of the node leg in order to stop feeding the pathological element with blood.
The technique is used for bloodless removal of internal hemorrhoids and is characterized by a short list of contraindications, a minimal risk of complications and a short recovery period.
Before the operation, you should cleanse the intestines, and during a short rehabilitation period, adhere to a diet, observe a protective regime and take medications prescribed by a doctor.
The only drawback of the low-traumatic technique is its limited use.Ligation is not recommended for irreducible hemorrhoids, for large and multiple elements, as well as for complicated pathology. Therefore, you should contact the proctologist as early as possible!
The essence of the method
Ligation with latex rings is used for radical treatment of uncomplicated internal hemorrhoids I-II, in some cases – III stage of development.
The essence of the method is the mechanical disconnection of the node from the blood supply by ligating its legs.Cessation of the blood supply leads to the death of the node.
Departure of the nodes occurs together with the imposed ligature. This is an absolutely painless process, imperceptible to the patient.
Ligation of hemorrhoids with latex rings is an effective method. To prevent the disease from returning, it is necessary to adhere to the rules of prevention.
The most common indication for latex ring ligation – is chronic internal hemorrhoids I-III stages.In advanced cases, doctors will have to turn to a full-fledged surgical operation to excision the nodes.
In order to choose the right method of intervention, a minimum amount of diagnostic procedures is prescribed.
The main diagnostic procedure is endoscopic examination of the rectum (anoscopy). This absolutely harmless method for the body will provide a full amount of information:
___ • the number of internal hemorrhoids, their size and location,
___ • the state of the intestinal mucosa,
___ • the presence of complications and concomitant pathologies of the rectum
In cases where there is reason to suspect a pathological process in the overlying parts of the large intestine, a colonoscopy is prescribed.
If the decision is made in favor of ligation, standard preoperative diagnostic examinations (laboratory tests) are prescribed.
The ligation procedure will have to be postponed in case of an acute inflammatory process, as well as exacerbations of chronic diseases. Treatment is not carried out during the recovery period after serious illnesses, vascular accidents, injuries, operations.
Ligation of the internal node is not indicated for combined (internal and external) hemorrhoids, as well as in cases where the underlying disease is accompanied by other pathologies of the rectum:
___ • proctitis,
___ • anal fissure,
___ • polyps,
___ • malignant intestinal tumors.
In addition, minimally invasive interventions are not prescribed for complicated forms of pathology (thrombosis, rectal fistulas, bleeding).
Carefully carry out interventions in case of blood clotting disorders, liver pathologies, diabetes mellitus, severe pathologies of the cardiovascular system.
Preparation for the procedure starts in 2-3 days . It is necessary to stop taking medications that affect blood clotting (aspirin, ibuprofen), and switch to an intestinal-friendly diet.
The list of restrictions includes:
___ • coarse vegetable fiber (cabbage, fresh vegetables and fruits),
___ • legumes,
___ • whole milk,
___ • fatty foods,
___ • sweets,
___ • pickles, pickles, spices ,
___ • carbonated drinks,
___ • alcohol.
On the eve of the visit to the doctor , an early light supper is recommended, and a light breakfast in the morning. Intestinal cleansing is carried out twice: in the evening and in the morning with the help of Mikrolax microclysters.
The procedure is performed with the patient lying on his side with bent legs. The doctor-proctologist inserts an anoscope into the anus in order to apply an elastic hypoallergenic loop – a ligature to the base of the node under visual control.
For the operation, a special device is used – vacuum ligator , with the help of which the pathological element is captured, and a latex ring is put on it.
The manipulation is absolutely painless for the patient and therefore can be performed without anesthetic aid.Carrying out time – less than an hour. At the end of the procedure, the patient can go home.
The doctor applies only one ligature per session. If there are several nodes, the procedure will have to be repeated. The interval between operations should be at least 1 week. Large formations are removed in stages. Your doctor will set the date for your return visit.
Unpleasant consequences and methods of dealing with them
The most common side effect after placing a latex ring on an internal hemorrhoid is foreign body sensation in the rectum. Medical measures in such cases are not indicated; over time, the intensity of sensations decreases and does not cause anxiety to the patient.
In some cases, the appearance of pain syndrome is possible, the severity of which depends on a number of factors (the size of the node, its location, the characteristics of the patient’s individual sensitivity).
Pain should be relieved with the medication recommended by the attending physician. In case of resistant (permanent) pain syndrome, you should consult a specialist, since pain can be a symptom of the development of complications.
Thrombus formation, bleeding, inflammation
___1. Thrombus formation is a very rare complication. The actions of doctors will depend on the situation: both conservative and surgical treatment can be prescribed.
___2. Sometimes there is such an unpleasant side effect as staining of feces with blood . Most often, blood in the feces appears during the natural discharge of the pathological element. Less often, a symptom indicates trauma to the node with feces and / or the development of complications.If severe bleeding occurs, an urgent need to consult a doctor.
___3. Inflammatory processes with minimally invasive interventions are extremely rare. As a rule, an infectious and inflammatory process occurs as a result of injury to the nodule with solid feces, therefore, to prevent complications, it is necessary to adhere to a diet.
Latex Ring Slip
Premature slipping of the latex ligature is a rather rare complication that invalidates the result of the operation.As a rule, excessive physical effort (lifting weights, sports, straining with constipation) becomes the cause of slipping. If this happens, contact your healthcare professional for a repeat procedure.
Conservation regime and hygiene procedures
All ongoing rehabilitation measures are aimed at speedy wound healing and prevention of complications:
___ • In the first days of , it is necessary to limit physical activity.You can not lift weights over 5 kg and go to the bathhouse.
___ • One week 90 076 after the operation, moderate physical activity is allowed: swimming and walking.
___ • The ban on power sports and hard physical labor remains for a month.
___ • The perineal toilet is performed as usual (twice a day, morning and evening).
The vast majority of complications after ligation are caused by trauma from hard feces.Therefore, it is necessary to exclude from the menu products that have an irritating and strengthening effect:
___ • semolina, rice,
___ • potatoes,
___ • legumes,
___ • spicy and smoked dishes,
___ • bakery products from wheat,
___ • carbonated drinks, 90 238 ___ • alcohol.
It is necessary to observe the temperature regime: you must not eat too hot, as well as too cold dishes. The optimal solution is warm, soft food: stewed, boiled, mashed (fried and smoked foods are strictly prohibited).
In order for the rehabilitation process to proceed at a normal pace, you need good nutrition: dietary meat, poultry, fish, boiled or stewed vegetables, dairy products.
To prevent complications of hemorrhoid ligation, proctologists prescribe drugs of several groups.
Painkillers from the group of non-steroidal anti-inflammatory drugs reduce the severity of pain and inhibit the inflammatory response. Such drugs are prescribed by mouth (Nurofen, Ketanov).
To avoid injury from hard feces, softening stool laxatives (for example, Forlax) are taken.
How to prevent relapse
Hemorrhoid ligation is a reliable method of treatment. However, if the patient has a predisposition to the development of this disease, hemorrhoids may recur.
To prevent relapse, the number of factors contributing to the development of pathology should be minimized:
___ • normalize stool,
___ • get rid of excess weight,
___ • refuse spicy food and alcohol,
___ • avoid prolonged sitting,
___ • to limit heavy physical activity, to visit a bath, sauna,
___ • it is recommended to engage in physiotherapy exercises,
___ • to timely treat diseases of the gastrointestinal tract and genitourinary system.
Statistics show that if all recommendations are followed, the relapse-free period after ligation of the nodes can last indefinitely (10-15 years or more).
Can the operation be postponed?
Hemorrhoid ligation is a routine procedure that can always be postponed. Even a gentle intervention should be carried out against a background of physical and psychological well-being.
However, it should be borne in mind that chronic hemorrhoids are prone to the development of complications such as:
___ • thrombosis and bleeding of the node,
___ • infectious and inflammatory complications (proctitis, paraproctitis),
___ • anal fissure.
At the stage of irreducible hemorrhoids, with large and / or multiple nodes, as well as in the event of complications, doctors will have to abandon low-traumatic treatment methods in favor of traditional surgery (hemorrhoidectomy).
Prolonged course of chronic hemorrhoids, accompanied by bleeding, leads to anemia, physical and nervous exhaustion.
Ligation of nodes is the optimal solution for uncomplicated stage I-III hemorrhoids with a small number of small elements.
Our clinical experience proves that this procedure is highly effective and well tolerated by patients. Unpleasant side effects are extremely rare and can be successfully controlled by conservative measures. Compliance with the basic rules of relapse prevention guarantees a long-term effect of the operation.
Proctologists of the GKB № 31 clinic use the whole range of hemorrhoid treatment methods: conservative therapy, traditional surgical operations, as well as minimally invasive techniques:
___ • Sclerotherapy ,
___ • hemorrhoidal ligation,
___ • radio wave surgery.
Come, we are waiting for you!
Learn more about the direction Proctology
Make an appointment with our specialists
You can make an appointment for a paid appointment to the doctor by calling of the Consultative and Diagnostic Center +7 (499) 936-99-89 , or by filling out the form presented.
Conditions for the provision of paid services can be found here
You can make an appointment for the OMS policy and in the direction of by calling +7 (499) 936-99-71 .
90,000 Coronavirus vaccination: duration, side effects, where to do
TOMSK, January 16 – RIA Tomsk. Mass vaccination of the population against coronavirus started in Tomsk
area. Are there any contraindications, what side effects are possible, is it enough
one vaccination for life and whether it eliminates the need to wear a mask, RIA Tomsk told the head of the department of medical prevention
Regional Department of Health Rimma Voloshin.
it was reported that vaccination against COVID-19 in the Tomsk region started on November 11
2020.The first vaccinations were intended for health workers, and later –
teachers. By mid-January 7,042 doses of vaccine have been delivered to the region
“Gam-KOVID-vak” (trade mark “Sputnik-V”). By March their
the total number should be 53 thousand doses. An online service has been opened in the region for
prior appointment for vaccination.
Alexandrovna, tell us who has the right to a free vaccination?
supplied free of charge by the ministry of health, so it is put
free of charge, and everyone over 18 years of age has the right to such vaccination,
living in the Tomsk region.
do you need to be vaccinated?
© RIA Tomsk. Taisiya Vorontsova
There are several ways to do this: the residents themselves choose the most convenient for them.
For example, this is an appeal to a medical organization at the place of attachment. Also
a citizen can leave an application on the website,
after which these lists are processed and the data is sent to that medical
an organization where a citizen has expressed a desire to be vaccinated, after which he is invited
In addition, you can call the Health Department hotline by phone
8 (3822) 516-616 and inform about your desire to be vaccinated. Now it is being decided
the question of the possibility of registering for vaccination through the portal of public services.
vaccinated, can he go to work the next day and study
your usual business?
– Of course.
After the vaccination, the person works, the sick leave is not
the opinion that it is not necessary to wear a mask after vaccination. Is it so?
on the contrary, you need to be careful: after the vaccine is administered, you need to continue to wear a mask,
use antiseptics, keep distance and avoid mass
activities. The development of immunity occurs only three weeks after
the first stage and three weeks later from the second stage. In the end, we only have
42 days after vaccination, sufficient antibodies are produced to
this period, and especially in the first days after vaccination, must be excluded
hypothermia, visiting a bathhouse, alcohol abuse, exclude
foods that cause allergic reactions.
Side effects and duration
are there any side effects from the vaccine?
as we began to vaccinate residents of the Tomsk region (from October 2020.
– Ed.) No side reactions are observed.Also severe complications and fatal
no cases were recorded among those who received the vaccine. Yes there is
temperature reaction within one to two days, but this is considered normal. How
and to the introduction of any drug, an allergic reaction is possible.
When do I need to see a doctor after vaccination?
it is worth a visit to the doctor in case of temperature above 40 degrees, some convulsive
manifestations of or a severe allergic reaction, for example, a generalized rash,
contraindications, except for childhood, does this vaccine have?
severe allergic reactions, hypersensitivity, acute infectious and
non-infectious diseases in the acute stage, as well as pregnancy and breastfeeding
© provided by ZOLT
about vaccination is taken by a general practitioner who preliminarily examines
a person has already had a coronavirus, does it make sense for him to get vaccinated against
of this disease?
there is.It is believed that after the disease, short-term immunity is developed – from
three to six months, so after an illness, of course,
need to be vaccinated.
should be tested for antibodies before vaccination?
testing is not provided. If a person himself wants to know the level of antibodies,
then this is his right.
– Which one
the duration of the vaccine?
that immunity after vaccination is short-term, then, like influenza vaccination,
vaccination against coronavirus will be carried out annually.
are there options?
a person wants to supply an imported vaccine, that is, is there such an opportunity in
Russia has registered two vaccines: “Gam-COVID-vac” and
“EpiVacCorona”. So far only
“Gam-COVID-vac”, when the second vaccine will be delivered, we will
offer residents an alternative vaccination.
I have no information on the availability and cost of the imported vaccine.
will there be a vaccine for children?
children, the coronavirus passes in a different, more favorable form, so now
all efforts are devoted to the development of a vaccine for adults.
vaccines for children are underway, but while it is not available, you need to follow the usual measures
safety, such as avoiding crowds, not communicating with
a sick person, use personal protective equipment.
What is intimate plastic surgery – description of the operation
Intimate contour plastic is a method that allows you to replenish the volume of soft tissues by injecting drugs with hyaluronic acid.
Hyaluronic acid is the main component of the intercellular substance, which is responsible for its viscosity. With age, the amount of hyaluronic acid in the skin progressively decreases, which leads to degradation and wrinkling processes.
With the help of intimate filling, aesthetic and functional deficiencies associated with age-related changes or individual characteristics of the body are eliminated.
This technique is less traumatic, safe and, practically, painless.
There are medical, sexological, and aesthetic indications for intimate plastic surgery.
Medical indications include:
The asymmetry of the labia.
Gaping of the genital fissure, postpartum and involutive dilatation of the vestibule of the vagina.
Cicatricial changes of the vulva (postpartum ruptures, post-traumatic, postoperative)
Dry mucous membranes and kraurosis of the vulva, accompanied by persistent itching.
For sexological indications:
– to improve the quality of sexual life, by introducing fillers into the G-spot, the head of the clitoris, which, in turn, reduces psychological discomfort, increases libido, self-esteem
indicated for the correction of oligo- and anorgasmia
Aesthetic indications include:
-reduction of turgor and elasticity of the skin of the anogenital region, age-related changes, laxity and sagging of the soft tissues of the perineum and vaginal walls, lipodystrophy of the labia majora, for example, due to a sharp decrease in body weight
-correction of the shape and volume of large and small labia, including the elimination of acquired or congenital asymmetry
– restoration of elasticity and elasticity of tissues
-moistening and nutrition
– improving the accessibility of the clitoris and the G-spot to address the issue of the absence or decrease in the brightness of orgasm
-treatment of urinary incontinence, for example, due to hypermobility of the urethra
Contraindications: individual intolerance to drugs with hyaluronic acid, urinary tract infections, cancer, fever, of unknown origin, bleeding disorders, autoimmune diseases, mental illness, pregnancy, age up to 18 years
-inflammation at the injection site
– redness of erythema
– hematomas, induration
– minor bleeding
– exclude visits to the pool, gym, sauna for 7-10 days
– sexual rest for 5-7 days
– for several days, physical activity that causes compression of the injection area (cycling, horse riding) should be avoided
– exclude physiotherapy, taking enzyme preparations within a month
The duration of the effect after the intimate filling procedure is 180-240 days.