What are the 5 stages of cold sores. How long do cold sores typically last. What triggers cold sore outbreaks. How can cold sores be treated effectively. Are cold sores contagious. How can cold sores be prevented.

Understanding Cold Sores: Causes and Transmission

Cold sores, also known as herpes labialis, are caused by the nongenital herpes simplex virus type 1 (HSV-1). These painful blisters typically appear on or around the lips and mouth. While HSV-1 is often contracted during childhood through nonsexual contact, adults can also acquire the infection through sexual activity.

The virus has a unique ability to hibernate inside skin cells and neurons beneath the skin’s surface. It remains dormant until triggered by various factors, at which point it reactivates and causes a cold sore outbreak.

How is HSV-1 Transmitted?

HSV-1 transmission occurs through direct contact with the virus, typically through:

• Kissing an infected person
• Sharing utensils, drinkware, or cosmetics with someone who has an active cold sore
• Using towels or other personal items that have come into contact with the virus

It’s crucial to note that cold sores are most contagious during the third stage of their development, known as the ulcer or weeping stage. During this phase, the blister ruptures, releasing fluid containing the virus.

The Five Stages of Cold Sore Development

Cold sores typically progress through five distinct stages, with the entire cycle lasting between 9 and 12 days. Understanding these stages can help individuals recognize symptoms early and seek prompt treatment.

Stage 1: Prodrome (Day 1-2)

The first stage, known as the prodrome stage, is characterized by:

• A tingling, itching, or burning sensation beneath the skin around the mouth or base of the nose
• Possible symptoms of malaise, fever, and tender or swollen lymph nodes

At this stage, no visible blister is present. Individuals with recurring cold sores may experience milder symptoms. Medical professionals recommend initiating treatment as soon as these early signs appear.

Stage 2: Blister Formation (Day 2-3)

If left untreated, a fluid-filled blister typically develops within 1 to 2 days after the initial symptoms. This marks the beginning of the visible cold sore.

Stage 3: Ulceration (Day 4)

Around the fourth day, the blister opens up and releases its fluid. This stage, known as the ulcer or weeping stage, is when cold sores are most contagious and often most painful.

Stage 4: Crusting (Day 5-8)

Between days 5 and 8, the cold sore begins to dry up, forming a yellow or brown crust. This crust may crack or break, so care must be taken during this stage.

Stage 5: Healing (Day 9-12)

In the final stage, several scabs may form and flake off. Each new scab will be smaller than the previous one until the wound heals completely. In most cases, cold sores do not leave permanent scars.

Effective Treatment Options for Cold Sores

Treating cold sores promptly can significantly reduce their duration and severity. Both oral and topical medications are available, and in some cases, a combination of both may be recommended.

Oral Medications

Common oral medications for cold sores include:

• Acyclovir (Zovirax)
• Famciclovir (Famvir)
• Valacyclovir (Valtrex)

These antiviral drugs work by inhibiting the replication of the herpes simplex virus, thereby shortening the duration of the outbreak and reducing symptoms.

Topical Treatments

Topical treatments that can be applied directly to the affected area include:

• Acyclovir (Zovirax) cream
• Docosanol (Abreva)
• Penciclovir (Denavir) cream

These medications can help alleviate symptoms and may speed up the healing process when applied at the first sign of an outbreak.

Treatment Efficacy

Research has shown that early treatment can significantly impact the course of a cold sore outbreak. A study published in Antimicrobial Agents and Chemotherapy found that high doses and short courses of valacyclovir may reduce the duration of a cold sore by approximately one day. Moreover, starting medication at the first sign of symptoms may prevent the cold sore from fully developing.

Triggers and Risk Factors for Cold Sore Outbreaks

Understanding what triggers cold sore outbreaks can help individuals take preventive measures. According to the American Family Physician (AAP), several factors can reactivate the dormant virus, including:

• Stress
• Fever
• Sun exposure
• Extreme temperatures
• Ultraviolet radiation
• Compromised immune system
• Physical injury to the affected area

Identifying personal triggers can help individuals take steps to minimize their risk of recurrent outbreaks.

Prevention Strategies for Cold Sores

While it’s not always possible to prevent cold sores entirely, several strategies can reduce the frequency and severity of outbreaks:

Preventive Medications

For individuals with chronic cold sores, doctors may recommend daily preventive treatments. The AAP suggests the following dosages:

• Acyclovir: 400 milligrams (mg), twice daily
• Valacyclovir: 500 mg, once daily

Lifestyle and Dietary Measures

Additional preventive measures recommended by healthcare professionals include:

• Consuming foods high in lysine, such as red meats, fish, and dairy products
• Applying sunscreen to the face and lips before sun exposure
• Managing stress through relaxation techniques or exercise
• Maintaining a strong immune system through a balanced diet and regular exercise
• Avoiding sharing personal items with others, especially during an active outbreak

The Impact of Cold Sores on Quality of Life

While cold sores are generally not dangerous for most people, they can significantly impact an individual’s quality of life. The physical discomfort, coupled with the visible nature of the sores, can lead to emotional distress and social anxiety.

Psychological Effects

Some individuals may experience:

• Embarrassment or self-consciousness about their appearance
• Anxiety about potential transmission to partners or loved ones
• Frustration with recurrent outbreaks
• Depression, especially in cases of frequent recurrences

It’s important for those affected by cold sores to seek support if they’re struggling with the psychological impact of the condition. Mental health professionals can provide valuable coping strategies and support.

Advancements in Cold Sore Research and Treatment

The field of cold sore treatment is continuously evolving, with researchers exploring new approaches to manage and prevent outbreaks more effectively.

Gene Editing Technologies

Recent studies have investigated the potential of gene editing technologies, such as CRISPR-Cas9, to target and eliminate the herpes simplex virus from infected cells. While still in the early stages, this research holds promise for developing more targeted treatments in the future.

Immunotherapy

Researchers are also exploring immunotherapy approaches to enhance the body’s natural defense against the herpes simplex virus. These treatments aim to boost the immune system’s ability to recognize and combat the virus, potentially reducing the frequency and severity of outbreaks.

Novel Antiviral Compounds

Ongoing research is focused on developing new antiviral compounds that can more effectively target the herpes simplex virus. These efforts aim to create treatments with fewer side effects and greater efficacy in preventing and treating cold sores.

Cold Sores in Special Populations

While cold sores are generally manageable for most people, certain populations may face additional challenges or risks associated with HSV-1 infections.

Pregnant Women

Pregnant women with active cold sores should consult their healthcare provider, as there is a small risk of transmitting the virus to the baby during delivery. In some cases, a cesarean section may be recommended to reduce this risk.

Immunocompromised Individuals

People with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy, may experience more severe or frequent cold sore outbreaks. These individuals may require more aggressive treatment and prevention strategies.

Infants and Young Children

HSV-1 infections can be particularly dangerous for newborns and young infants, potentially leading to severe complications. Parents and caregivers with active cold sores should take extra precautions to avoid transmitting the virus to infants.

Understanding the unique needs and risks of these special populations is crucial for healthcare providers in developing appropriate management strategies.

The Future of Cold Sore Management

As our understanding of the herpes simplex virus and its mechanisms continues to grow, the future of cold sore management looks promising. Researchers and healthcare professionals are working towards more effective prevention strategies, targeted treatments, and potentially even a cure for HSV-1 infections.

Personalized Medicine Approaches

Advancements in genetic testing and personalized medicine may lead to more tailored treatment plans for individuals with recurrent cold sores. By identifying specific genetic factors that influence susceptibility to outbreaks, healthcare providers may be able to develop more effective prevention and treatment strategies for each patient.

Nanotechnology in Drug Delivery

The application of nanotechnology in drug delivery systems holds potential for improving the efficacy of antiviral treatments. Nanoparticles could potentially deliver medications more precisely to infected cells, enhancing their effectiveness while minimizing side effects.

Vaccine Development

While a vaccine for HSV-1 is not yet available, ongoing research efforts are focused on developing preventive and therapeutic vaccines. These could potentially provide long-term protection against cold sore outbreaks or help manage symptoms in those already infected.

As research progresses, individuals affected by cold sores can look forward to more advanced and effective management options in the coming years. In the meantime, early recognition of symptoms, prompt treatment, and adherence to preventive measures remain the best strategies for managing cold sores and minimizing their impact on daily life.

Cold sore stages: Pictures, duration, and treatment

There are five stages of cold sores. These lead from the initial tingling in the area to the healing stage.

Cold sores, also known as herpes labialis, are caused by nongenital herpes simplex virus type 1. People can develop a cold sore on their lips or in their mouth.

Transmission of the nongenital herpes simplex virus type 1 (HSV-1) occurs during childhood through nonsexual contact, but adults can contract the infection through sexual activity. HSV-1 hibernates inside skin cells and neurons under the skin until a trigger stimulates it.

Before the cold sore appears, people may feel a burning, stinging, or itching sensation on their lips. For best results, doctors recommend starting treatment as soon as the tingling begins, before the cold sore appears.

In this article, we discuss the stages of a cold sore and what to do if a cold sore develops. We also explore how doctors treat the infection and how people can avoid getting a cold sore.

A cold sore develops in five stages and will typically last between 9 and 12 days.

Stage 1

Initially, people will feel a tingling, itching, or burning sensation underneath the skin around the mouth or base of the nose. Doctors call this the prodrome stage.

Other symptoms that may occur during this stage include:

• malaise
• fever
• tender or swollen lymph nodes

At this first stage of the cold sore, people will not see a blister. People with recurring cold sores may present milder symptoms. Doctors recommend starting treatment as soon as these symptoms begin.

Treatment for cold sores may include oral or topical medications. Sometimes people will use both types to treat a cold sore.

Oral medications for cold sores include:

• acyclovir (Zovirax)
• famciclovir (Famvir)
• valacyclovir (Valtrex)

Topical treatments for cold sores include:

• acyclovir (Zovirax) cream
• docosanol (Abreva)
• penciclovir (Denavir) cream

Treatment aims to shorten the duration of the cold sore. In one study published in Antimicrobial Agents and Chemotherapy, researchers found that high doses and short courses of valacyclovir may reduce the duration of a cold sore by about 1 day.

Taking medication when symptoms first appear can prevent or block the cold sore from appearing.

Stage 2

If the person does not use any medication, a fluid-filled blister will likely develop around 1 to 2 days after the initial symptoms.

Stage 3

The third stage, which occurs around day 4, involves the blister opening up and releasing its fluid. Doctors call this stage the ulcer or weeping stage. If another person comes into contact with the blister’s fluid, they may develop a cold sore as well.

Cold sores are contagious and tend to be painful during this stage.

Stage 4

Between days 5 and 8, the cold sore will dry up, leaving a yellow or brown crust. The crust will eventually flake off.

People must take care of the scab during this stage because it can crack or break.

Stage 5

The final stage of a cold sore is the healing stage.

Several scabs may form and flake off during this stage. Every new scab will be smaller and smaller until the wound heals completely. Most often, the cold sore will not leave a scar.

Some doctors suggest that a cold sore can last around 2 to 6 weeks.

People who come into contact with another person’s cold sore may be at risk of infection. However, they would have to come into contact with the fluid when the blister ruptures.

Some people may develop recurring cold sores. According to the American Family Physician (AAP), various stimuli can awaken the hibernating virus, such as:

• stress
• fever
• sun exposure
• extremes in temperature
• ultraviolet radiation
• a compromised immune system
• injury

When a cold sore enters the ulcer or weeping stage, around the fourth day, the cold sore becomes contagious.

People who come into contact with the fluid from another person’s open blister can develop a cold sore between 2 to 20 days after contact.

People can come into contact with fluid from another person’s cold sore through kissing or sharing utensils, drinkware, cosmetics, or towels.

Doctors suggest that treating a cold sore at the start of symptoms, before the blister appears, may prevent the cold sore from appearing.

People with a history of cold sores can usually detect the initial symptoms and know they need to start treatment right away.

Some people get chronic cold sores and may require preventive treatments. Taking acyclovir or valacyclovir every day may prevent cold sores.

According to the AAP, the recommended doses for each drug are:

• acyclovir 400 milligrams (mg), twice daily
• valacyclovir 500 mg, once daily

People with chronic cold sores will need to take preventive treatments regularly. Also, doctors and dentists recommend:

• eating foods high in lysine, such as red meats, fish, and dairy
• applying sunscreen to the face and lips before going outside throughout the year
• shaving with a disposable razor blade when a cold sore appears
• replacing toothbrushes
• avoiding stress

People should avoid intimate contact with people who have cold sores. Avoid sharing utensils, toothbrushes, towels, and razors.

People with cold sores should avoid touching the blister, and if they do, they need to wash their hands thoroughly.

Cold sores are a common infection of nongenital HSV-1 that people can contract through sexual and nonsexual activities.

People who start treatment when they feel tingling and itching around their lips may block the cold sore from appearing.

If a cold sore appears, it will go through five stages from the prodrome stage to healing. During the ulcer stage, people can transmit the virus to another person. The fluid in the blister contains the virus. People with cold sores must avoid kissing and sharing utensils, towels, and drinkware.

A person may have a cold sore for about 2 weeks, but some doctors suggest that a cold sore can last up to 6 weeks. Medications can help shorten the duration of a cold sore.

Cold sore stages: Pictures, duration, and treatment

There are five stages of cold sores. These lead from the initial tingling in the area to the healing stage.

Cold sores, also known as herpes labialis, are caused by nongenital herpes simplex virus type 1. People can develop a cold sore on their lips or in their mouth.

Transmission of the nongenital herpes simplex virus type 1 (HSV-1) occurs during childhood through nonsexual contact, but adults can contract the infection through sexual activity. HSV-1 hibernates inside skin cells and neurons under the skin until a trigger stimulates it.

Before the cold sore appears, people may feel a burning, stinging, or itching sensation on their lips. For best results, doctors recommend starting treatment as soon as the tingling begins, before the cold sore appears.

In this article, we discuss the stages of a cold sore and what to do if a cold sore develops. We also explore how doctors treat the infection and how people can avoid getting a cold sore.

A cold sore develops in five stages and will typically last between 9 and 12 days.

Stage 1

Initially, people will feel a tingling, itching, or burning sensation underneath the skin around the mouth or base of the nose. Doctors call this the prodrome stage.

Other symptoms that may occur during this stage include:

• malaise
• fever
• tender or swollen lymph nodes

At this first stage of the cold sore, people will not see a blister. People with recurring cold sores may present milder symptoms. Doctors recommend starting treatment as soon as these symptoms begin.

Treatment for cold sores may include oral or topical medications. Sometimes people will use both types to treat a cold sore.

Oral medications for cold sores include:

• acyclovir (Zovirax)
• famciclovir (Famvir)
• valacyclovir (Valtrex)

Topical treatments for cold sores include:

• acyclovir (Zovirax) cream
• docosanol (Abreva)
• penciclovir (Denavir) cream

Treatment aims to shorten the duration of the cold sore. In one study published in Antimicrobial Agents and Chemotherapy, researchers found that high doses and short courses of valacyclovir may reduce the duration of a cold sore by about 1 day.

Taking medication when symptoms first appear can prevent or block the cold sore from appearing.

Stage 2

If the person does not use any medication, a fluid-filled blister will likely develop around 1 to 2 days after the initial symptoms.

Stage 3

The third stage, which occurs around day 4, involves the blister opening up and releasing its fluid. Doctors call this stage the ulcer or weeping stage. If another person comes into contact with the blister’s fluid, they may develop a cold sore as well.

Cold sores are contagious and tend to be painful during this stage.

Stage 4

Between days 5 and 8, the cold sore will dry up, leaving a yellow or brown crust. The crust will eventually flake off.

People must take care of the scab during this stage because it can crack or break.

Stage 5

The final stage of a cold sore is the healing stage.

Several scabs may form and flake off during this stage. Every new scab will be smaller and smaller until the wound heals completely. Most often, the cold sore will not leave a scar.

Some doctors suggest that a cold sore can last around 2 to 6 weeks.

People who come into contact with another person’s cold sore may be at risk of infection. However, they would have to come into contact with the fluid when the blister ruptures.

Some people may develop recurring cold sores. According to the American Family Physician (AAP), various stimuli can awaken the hibernating virus, such as:

• stress
• fever
• sun exposure
• extremes in temperature
• ultraviolet radiation
• a compromised immune system
• injury

When a cold sore enters the ulcer or weeping stage, around the fourth day, the cold sore becomes contagious.

People who come into contact with the fluid from another person’s open blister can develop a cold sore between 2 to 20 days after contact.

People can come into contact with fluid from another person’s cold sore through kissing or sharing utensils, drinkware, cosmetics, or towels.

Doctors suggest that treating a cold sore at the start of symptoms, before the blister appears, may prevent the cold sore from appearing.

People with a history of cold sores can usually detect the initial symptoms and know they need to start treatment right away.

Some people get chronic cold sores and may require preventive treatments. Taking acyclovir or valacyclovir every day may prevent cold sores.

According to the AAP, the recommended doses for each drug are:

• acyclovir 400 milligrams (mg), twice daily
• valacyclovir 500 mg, once daily

People with chronic cold sores will need to take preventive treatments regularly. Also, doctors and dentists recommend:

• eating foods high in lysine, such as red meats, fish, and dairy
• applying sunscreen to the face and lips before going outside throughout the year
• shaving with a disposable razor blade when a cold sore appears
• replacing toothbrushes
• avoiding stress

People should avoid intimate contact with people who have cold sores. Avoid sharing utensils, toothbrushes, towels, and razors.

People with cold sores should avoid touching the blister, and if they do, they need to wash their hands thoroughly.

Cold sores are a common infection of nongenital HSV-1 that people can contract through sexual and nonsexual activities.

People who start treatment when they feel tingling and itching around their lips may block the cold sore from appearing.

If a cold sore appears, it will go through five stages from the prodrome stage to healing. During the ulcer stage, people can transmit the virus to another person. The fluid in the blister contains the virus. People with cold sores must avoid kissing and sharing utensils, towels, and drinkware.

A person may have a cold sore for about 2 weeks, but some doctors suggest that a cold sore can last up to 6 weeks. Medications can help shorten the duration of a cold sore.

Herpes (colds on the lips)

Herpes on the lips has several names: “cold” on the lips, fever on the lips, herpes of the lips, herpes labialis, labial or labial herpes.

“Cold” on the lips, mainly caused by herpes simplex virus type I (HSV-I) . 95% of people have this virus in their body. In rare cases, the cause of herpes lips is the herpes simplex virus type 2, (transmitted through oral sex).

The herpes simplex virus, which causes a “cold” on the lips, remains inside the human body for life. At the moment, no medicines and treatments have been developed that would completely destroy the herpes simplex virus in the human body.

Up to 10,000,000 Russians annually suffer from “colds” on the lips. Approximately every 5 Russians get herpes of the lips from 2 to 10 times a year. And only about 5% of the human race has immunity to HSV-I, the reasons for which are still unclear.

The virus enters the body in early childhood: at 3-4 years old, when the antibodies against the herpes virus transmitted to the baby by the mother are depleted. Most often, infection occurs if the child is kissed by carriers of the infection. For example, parents, brothers, sisters and other relatives. In addition to a kiss, the virus can enter the body along with the biological fluids of others, for example, with saliva.

Having come to visit us, it penetrates into the mucous membranes, reaches the nerve endings. Through them, with a current of fluid that feeds the nerves, it rises into the cranial cavity, where it “hides” in the nerve plexus, called the trigeminal ganglion , and “sleeps” there until the moment of reactivation.

Reactivation of the virus is possible at the moment when immunity “decreases”. “Decrease” in immunity can occur under the influence of: colds, flu, menstruation, emotional distress and stress, strong ultraviolet radiation, excessive alcohol consumption, indigestion and fatigue.

Causes of recurrence of herpes on the lips:

– Stress or emotional disorder;

– Various somatic diseases, in particular colds, flu, diabetes, HIV;

– Poisoning or intoxication;

– Alcohol, caffeine and smoking;

– Excessive ultraviolet exposure;

– Hypothermia or overheating;

– Coming of menstruation;

– Overwork and exhaustion;

– Malnutrition/diet or indigestion;

– Other individual factors;

After “awakening” the virus is sent to the nerves (like a train on rails) from the trigeminal ganglion back to the skin. It is important to know that branches that innervate the lips, oral mucosa, gums, skin on the earlobe and part of the cheek depart from the trigeminal plexus. In accordance with the outgoing nerves, lesions on the skin will also be located. As it passes through the nerve, the virus causes inflammation of the nerve tissue, which causes pain along the course of the nerve fiber.

Stages of development of a “cold” on the lips

In its development, the disease goes through stages IV:

Stage I – tingling.

At this time, most people feel that they are getting sick. Before a “cold” appears, the skin at the corners of the mouth or the inside of the lips, or on the tongue, or even all over the face begins to itch.
In a place where a recurrence of herpes will soon develop, harbingers of the disease appear: pain, tingling, tingling, itching. The skin over the site of the future relapse turns red.

The development of the disease can be prevented if drugs based on acyclovir (Zovirax ointment) are used at this stage. If you suffer from severe itching, you can take an aspirin or paracetamol tablet.

Stage II – the stage of inflammation, begins with a small painful vesicle, which gradually increases in size. The bubble is tense and filled with a clear liquid, which later becomes cloudy.

Stage III – stage of ulceration. The bubble bursts, and a colorless liquid flows out of it, stuffed with billions of viral particles. In its place, an ulcer is formed.

At this point, the sick person is highly contagious, as she releases a huge amount of viral particles into the environment. Because of the soreness and sores on the face, people are most annoyed by this stage.

IV stage eschar formation. A crust forms over the sores, if damaged, pain and bleeding can occur.

Herpes rashes are most often located on the red border of the lips, but can also be on the nose, on the cheeks, in the ears, on the forehead, in the oral cavity: on the gums, the inner surface of the lips and cheeks.

Complications of the “cold” on the lips

If personal hygiene rules are not followed, the virus can affect other parts of the body: if you rub your eyes with your hands after touching the blisters or sores, you can provoke ophthalmic herpes 9 0006 or herpes eye – severe eye damage, sometimes leading to decreased vision and even blindness. Herpetic eczema may develop – a virus infection of the skin of the fingers.

If you kiss someone with ulcerated lips, you can pass the infection to the child or loved ones.

Oral sex with a partner with an active “cold” on the lips can lead to “ genital herpes “. Those. during an outbreak of a “cold” on the lips, herpes can be mechanically transferred from the lips of an “active” sexual partner in oral sex to the genitals of the recipient of oral caresses.

This is how patient M. describes the severe course of herpetic infection on the lips: He is very worried about headaches and intoxication, as a rule, for no apparent reason, symptoms of severe poisoning appear. Tablets from the “head” help with difficulty, more or less saves an injection of analgin with diphenhydramine. Not a single doctor even wanted to talk about a headache and listen .”

In people with reduced immunity (immunosuppression, HIV infection), necrotic forms of the course with the formation of scars on the skin are possible. 6.” Colds are contagious! Always wash your hands with soap and water before and after touching cold sores, including after applying antiviral cream.

– Don’t touch your eyes! Especially women during make-up;

– Do not use saliva to wet contact lenses.

– Despite itching and pain, do not touch rashes, kiss, especially with children, use someone else’s lipstick or borrow your own, smoke one cigarette with a friend (girlfriend).

– Do not attempt to remove blisters or crusts to avoid transmission of infection to other parts of the body or bacterial infection.

– Stop oral sex! Oral sex during a “cold” on the lips of an “active” partner can cause genital herpes in a partner who is passively participating in oral sex. In this case, herpes from the lips of the “active” partner can be transferred to the genitals of the partner receiving caresses.
– If you have a cold on your lips, use individual dishes or towels, do not drink from other people’s glasses…

Newborn care. To avoid contracting herpes in the newborn, women who have cold sores on the lips should thoroughly wash their hands before touching their baby. If there are blisters or sores on the lips, a disposable surgical mask or gauze bandage should be used while caring for the child until the sores dry out. During a cold on the lips, do not kiss or sniff the child. If there is herpes on any other part of the body, then it must be carefully closed and in no case should it come into contact with the skin of the child.

REMEMBER:

– By the time you feel the tingling, the virus has already started, which means it’s time to start using the antiviral cream or other antiviral drugs prescribed by your doctor without delay;

– Use your medicine!

Medicines can help stop a relapse or speed up recovery.

Use aciclovir creams and ointments to help heal blisters and ulcers quickly, supplements containing either zinc or L-LYSINE. Remember that the use of corticosteroids (hydrocortisone ointment) reduces itching, but dramatically increases the area and severity of the lesions and the duration of the painful period.

– Apply antiviral ointments with cosmetic sticks.

To apply antiviral ointments (Acyclovir, Zovirax) to herpetic eruptions, use special cosmetic sticks, as shown in this picture.

Applying ointments to the lesion directly with the fingers can cause the virus to be transferred from the lips to the skin of the fingers.

– If you have frequent relapses, then make sure that you always have the medicine at hand. Like a passport or money, keep it with you at all times;

– Aciclovir creams and ointments must be used at least 4 times a day for 5 days.

– Valaciclovir may be prescribed for one-day treatment of lip herpes by a physician. If you take two tablets of valaciclovir 500 mg first in the morning and then in the evening, within 24 hours from the onset of the disease, then a cold on the lips will not develop or the healing of herpetic lesions will occur faster.

– If a “cold” does not go away within 10 days, be sure to consult a dermatologist, as a “cold” on the lips can be a symptom of other serious diseases that require specialized treatment.

– Prolonged course of a cold on the lips (more than 30 days) may be a sign of a sharp decrease in immunity, benign tumors and oncological diseases, HIV infection, lymphoproliferative diseases.

Lip herpes diagnosis | Haleon HealthPartner

Lip Herpes Cycle Information

• Stage 1: Stinging

  The tingling sensation that occurs before the rash appears is caused by reactivation of a dormant HSV-1 virus located in the trigeminal ganglion. ^2.3

  • The virus migrates to the nerve ending near the oral mucosa (lips/oral cavity) ³
  • It invades cells in/near the oral mucosa ⁴
  • Infection begins with the spread of the virus to multiple lesions from a single infected nerve ³

• Stage 2: Redness/swelling

  The immune system triggers an inflammatory process that leads to redness and swelling. ⁵

• Stage 3: Bubble

  Without adequate treatment, there is a high probability of progression of herpes of the lips to the formation of a bubble. ³

  • After 2-3 cycles of viral replication, the points of infection expand and connect, forming a clinically pronounced lesion against the background of hyperemia ³
  • A collection of small, fluid-filled blisters appear, usually on the vermilion border of the lip (the line separating the lip from adjacent skin) ⁶

• Stage 4: Ulcer

  • Fluid-filled blisters burst, forming a shallow red ulcer. The excreted fluid is highly contagious. ² Soft crust starts to form ⁵
  • Often the most painful stage ²

• Stage 5: Crusting

  Ulcer dries up, forming a tougher yellow/brown crust. A scab is forming. ^2.5

• Stage 6: Healing

  Dry eschar flakes off leaving residual redness and swelling. Skin re-epithelialization is complete and the virus returns to a latent state. ^2.7

Symptoms and situations in which pharmacists should advise the patient to seek medical advice