Gout otc treatment: Febuxostat Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Febuxostat Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Warnings:
Febuxostat may rarely cause very serious side effects including heart attack, stroke, or possibly fatal heart-related problems. Before taking this medication, tell your doctor if you have heart disease, chest pain (angina), or have had a heart attack or stroke in the past since these conditions may increase your risk. Discuss the risks and benefits of this medication and treatment options with your doctor. Get medical help right away if you have any of these very serious side effects: chest/jaw/left arm pain, unusual sweating, shortness of breath, fast/irregular heartbeat, dizziness, fainting, weakness on one side of the body, sudden vision changes, confusion, trouble speaking, sudden severe headache.
Warnings:
Febuxostat may rarely cause very serious side effects including heart attack, stroke, or possibly fatal heart-related problems. Before taking this medication, tell your doctor if you have heart disease, chest pain (angina), or have had a heart attack or stroke in the past since these conditions may increase your risk.
Discuss the risks and benefits of this medication and treatment options with your doctor. Get medical help right away if you have any of these very serious side effects: chest/jaw/left arm pain, unusual sweating, shortness of breath, fast/irregular heartbeat, dizziness, fainting, weakness on one side of the body, sudden vision changes, confusion, trouble speaking, sudden severe headache.
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Uses
Febuxostat is used to lower uric acid levels in people with gout. Febuxostat works by reducing the amount of uric acid made by the body. An increased uric acid level can cause gout.Because of the risk of very serious heart-related problems and stroke with febuxostat (see also Warning section), febuxostat should be used only after treatment with a medication called allopurinol did not work to lower your uric acid level, caused serious side effects, or is not recommended by your doctor. Febuxostat should be used only if you have symptoms caused by a high blood uric acid level.
How to use Febuxostat 80 Mg Tablet Hyperuricemia Agents (Non-Uricosuric)
Read the Medication Guide provided by your pharmacist before you start taking febuxostat and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Febuxostat is not a pain reliever. Your doctor may prescribe medication (such as colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent/treat a gout attack during the first several months you are taking febuxostat. Continue to take your prescribed medicines for gout attacks as directed by your doctor.
Tell your doctor if your condition lasts or gets worse.
Side Effects
See also Warning section.
Nausea may occur. If this effect lasts or gets worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Febuxostat may rarely cause serious (possibly fatal) liver disease. It may also cause an increase in liver enzymes. Your doctor will order blood tests to measure these enzymes. Keep all medical/lab appointments. Tell your doctor right away if you develop symptoms of liver disease, including nausea that doesn’t stop, stomach/abdominal pain, dark urine, yellowing eyes/skin.
Tell your doctor right away if you have any serious side effects, including: pink/bloody urine, painful urination.
Febuxostat may cause a rash that could be a sign of a severe reaction.
Get medical help right away if you develop any rash.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
See also Warning section.
Before taking febuxostat, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: cancer, heart disease (such as heart attack, chest pain/angina), stroke, liver disease, kidney disease, organ transplant.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if febuxostat passes into breast milk. Consult your doctor before breast-feeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: azathioprine, mercaptopurine.
Does Febuxostat 80 Mg Tablet Hyperuricemia Agents (Non-Uricosuric) interact with other drugs you are taking?
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Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
Lab and/or medical tests (such as uric acid blood level, liver function tests) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.
If you miss a dose, take it as soon as you remember.
If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
febuxostat 40 mg tablet
Color: light greenShape: roundImprint: 54 554
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 40 mg tablet
Color: greenShape: roundImprint: 40 F
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 40 mg tablet
Color: light greenShape: roundImprint: L 440
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 80 mg tablet
Color: light greenShape: teardropImprint: L441
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 80 mg tablet
Color: light greenShape: teardropImprint: 19 I
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 40 mg tablet
Color: light greenShape: roundImprint: 18 I
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 80 mg tablet
Color: light greenShape: roundImprint: 54 244
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 40 mg tablet
Color: whiteShape: roundImprint: M FX1
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 80 mg tablet
Color: yellowShape: oblongImprint: 80
This medicine is a light green, round, tablet imprinted with “54 554”.
febuxostat 80 mg tablet
Color: whiteShape: ovalImprint: M FX2
This medicine is a light green, round, tablet imprinted with “54 554”.
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Today on WebMD
10 natural treatments and home remedies
There is no cure for gout. However, a combination of medications and home remedies, such as staying hydrated and applying ice, may help to keep gout in remission.
Gout is a form of inflammatory arthritis that causes pain and discomfort, often in the toes, ankles, and knees. Making dietary changes can help people reduce their purine levels and the likelihood of having a gout flare.
This article discusses several natural remedies for gout.
Gout occurs when the body produces too much uric acid. This acid is a byproduct of when the body breaks down purines found in foods.
This excess uric acid forms crystals, which the body can deposit in all tissues. However, the crystals mainly build up in and around the joints, causing irritation, inflammation, and discomfort.
The crystals can also form growths around affected joints, known as tophi.
Home remedies for gout include:
1. Drinking plenty of water
When a person has gout, they can experience significant swelling and inflammation. One of the ways to reduce symptoms is by drinking more water.
Increasing fluid consumption can kick-start a person’s kidneys to release excess fluid, reducing swelling in a person with gout.
Water is best. However, other clear fluids, such as broths and herbal teas, are also good choices. People should avoid alcohol and sodas, which are high in purines.
However, anyone with congestive heart failure or kidney disease should talk with their doctor before increasing their fluid intake.
Discover more benefits of drinking water here.
2. Applying ice to affected joints
Applying a cloth-covered ice pack to the joint can help reduce gout-related inflammation.
Try applying an ice pack or other cold object wrapped in a thin towel for 20–30 minutes to help relieve pain.
Discover the best ways to make a cold compress here.
3. Reducing stress
Heightened stress can worsen gout symptoms. While it is not always possible to eliminate all sources of stress, the following tips might help:
- exercising if the pain does not limit movement
- asking for time off from work
- journaling or reading a favorite book
- meditating
Getting enough rest can also help a person feel less stressed.
Discover the causes of stress and how it impacts the body here.
4. Elevating the affected joints
Gout can cause pain and swelling, especially in the feet, hands, knees, and ankles.
One way to reduce swelling is by elevating the affected joints. This encourages blood and fluid to move away from the joint and back toward the heart.
A person can also use an ice pack with elevation to reduce their gout symptoms. These two remedies form part of the rest, ice, compression, and elevation (RICE) method.
Learn more about the RICE method here.
5. Taking over-the-counter pain relievers
While over-the-counter (OTC) anti-inflammatory medications, such as ibuprofen (Advil) and naproxen sodium (Aleve), may not be “natural,” they are good options for treating pain and inflammation due to gout.
People should never take more than the recommended dose and always ask a doctor whether OTC medicines might interfere with their other medications.
If OTC pain relievers do not help, a person may wish to ask a doctor about stronger prescription medications.
6. Drinking coffee
Some people believe drinking coffee may decrease the risk of experiencing gout.
A 2016 review and meta-analysis showed that those who drank more coffee were less likely to have gout. This may be because coffee can lower uric acid levels.
A further 2019 analysis reported that coffee consumption lowers gout risk, and may do this independently of lowering serum uric acid levels.
However, just because the study showed a correlation between higher coffee consumption and a lower risk of gout, this does not mean that coffee caused the lower risk.
Discover more potential health benefits of coffee here.
7. Eating a balanced diet
A balanced diet containing a variety of nutrient-dense, minimally processed foods can help lower uric acid levels and reduce a person’s risk of gout flares.
Plant-based diets can be of particular benefit for people with gout. Many fruits and vegetables are rich in antioxidants that can help reduce inflammation.
Learn more about the best diet for gout here.
8. Drinking lemon water
A 2015 study found that adding the juice of two freshly squeezed lemons to 2 liters of water each day reduced uric acid in people with gout.
The researchers concluded that lemon water helps neutralize uric acid in the body, thus helping to reduce levels.
Discover the benefits of drinking lemon water.
9. Limiting alcohol intake
According to the Arthritis Foundation, drinking more than two liquor-based drinks or two beers per day increases a person’s risk of gout.
Beer is high in purines, so avoiding it can benefit a person with gout.
Learn more about the link between beer and gout here.
10. Avoiding high-purine meats
Some meats contain high amounts of purines. Avoiding these might help to reduce a person’s gout symptoms.
Meats and fish that are high in purines include:
- bacon
- turkey
- veal
- venison
- organ meats, such as liver
- anchovies
- sardines
- mussels
- herring
- cod
- haddock
- trout
- scallops
Learn more about a low-purine diet here.
Doctors may prescribe medications to reduce symptoms of serious gout flares. These can include:
- Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as aspirin and ibuprofen can reduce pain and inflammation from gout.
- Colchicine: This medication helps stop uric acid from forming into crystals. Colchicine can help treat existing gout symptoms and help prevent future flares.
- Corticosteroids: Doctors may recommend oral or IV corticosteroids in cases where other medications have not reduced gout symptoms. These medications can reduce inflammation and pain.
Rarely, doctors may recommend surgery to treat severe cases of gout. A person may be a candidate for surgery if gout causes extreme pain, a major abnormality, or there is a severe infection at the site.
Surgery options for gout include:
- Joint fusion: If chronic gout causes significant tissue damage, surgeons may fuse a joint together to stabilize it.
- Joint replacement: Surgeons can remove affected joints and replace them with artificial structures.
- Tophi removal: A surgeon can remove tophi in cases of severe discomfort, abnormality, or infection.
Learn more about surgery for gout here.
Gout flares can be painful and exhausting. Treatments, including home remedies, can reduce symptoms and help prevent future flares.
Reaching or maintaining a moderate weight and exercising regularly can also help a person manage their condition.
If a flare does not start to ease after 48 hours, a person should call their doctor to determine if they need further medical treatments.
How to treat gout? – Lifehacker
August 24, 2020
Answers
This disease is difficult to confuse with something else. But only a doctor should make a diagnosis and prescribe drugs.
This question was sent by our reader. You can also ask your question to Lifehacker – if it is interesting, we will definitely answer.
What treatment is possible for a disease such as gout?
Anonymous
Vasily Kozak
Lifehacker editor.
What is gout
Sharp severe pain piercing the joint of the thumb, redness, swelling, “burning” skin – this is gout. Most often, it affects the joint of the big toe – one or both at once. But the disease is not limited to the foot. This form of arthritis can affect absolutely any joint in your body.
In this article you will find detailed information about what gout is, where it comes from, how to treat it and what to do to prevent the disease. Below we will consider only the last two points.
How to treat gout
First you need to accurately establish the diagnosis. Confusing gout with another disease is difficult, but the point in the question “Doctor, what’s wrong with me?” should be put only by a doctor – a therapist, surgeon or rheumatologist.
You may need to do more tests:
- Get a blood test to check your levels of uric acid and creatinine, a protein that is a marker of kidney function.
- X-ray the joint to rule out other causes of inflammation, such as trauma.
- Get an ultrasound to check for uric acid crystals in the joint.
- Make an analysis of the synovial fluid of the joint to determine the same uric acid crystals.
The necessary tests will again be prescribed by a doctor. If gout is confirmed, the doctor will prescribe medication. They fall into two categories:
- Medicines that relieve pain and prevent future attacks. These include both over-the-counter pain relievers (such as ibuprofen) and more serious prescription options. As well as corticosteroids – in the form of tablets or injections.
- Medicines that prevent complications from gout. Some of them block the production of uric acid in the body, while others improve kidney function.
Medicines are the most effective way to treat acute gout and prevent it from becoming chronic. But in order to make drug therapy more effective, it is necessary to supplement it with lifestyle changes.
By the way, they are also the prevention of this type of arthritis.
What to do in order not to get sick
- Eat a healthy diet. Limit the use of foods high in purines: meat (especially red), offal, semi-finished products (sausages, sausages), smoked meats. Do not abuse alcohol and sweetened soda.
- Drink more water. Fluid helps the body eliminate excess uric acid.
- Move more and exercise regularly. It is important to maintain normal weight. Just don’t overdo it. Exercising or eating too much can be harmful because it also causes the body to produce more uric acid.
- Eat low-fat fermented milk products. Such sour milk reduces the risk of gout, and therefore can serve as an alternative to meat in terms of obtaining protein.
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Arpimed
What Allopurinol is and what it is used for
Allopurinol is the active ingredient in Allopurinol.
Allopurinol slows down the rate of certain chemical reactions in the human body, resulting in lower levels of uric acid in the blood and urine.
Allopurinol is prescribed to reduce or prevent the deposition of uric acid and its salts (urates) in conditions where the body produces too much uric acid. These include gout, certain types of urolithiasis and kidney dysfunction, cancer treatment, and some other conditions. With gout, uric acid accumulates in the joints and in the muscle ligaments in the form of salt crystals. These crystals lead to the development of inflammatory reactions. Inflammatory reactions contribute to the development of edema of the periarticular tissue, excessive sensitivity and pain with a light touch. When moving in the joints, severe pain can begin.
What you need to know before you use Allopurinol
Do not take Allopurinol. If you are in any doubt, you should consult your doctor or pharmacist before using allopurinol. Warnings and precautions Talk to your doctor or pharmacist before using allopurinol, Special care must be taken when using allopurinol: If you develop a rash or other skin reaction, stop taking allopurinol and call your doctor right away. Children In children, the use of allopurinol is limited, except for some types of cancer (in particular, leukemia) and certain enzymatic disorders, such as Lesch syndrome – Nihena. Drug interactions Tell your doctor or pharmacist if you are taking the following medicines: Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including OTC and herbal products. Allopurinol may interfere with the effects of certain drugs. Some drugs can also interfere with the effects of allopurinol. Pregnancy and lactation Talk to your doctor before using allopurinol if you are pregnant, think you might be pregnant, or are breastfeeding. Influence on the ability to drive vehicles and mechanisms If you feel drowsiness, dizziness or incoordination, do not drive vehicles or other mechanisms. Important information about the ingredients of Allopurinol Allopurinol tablets contain lactose If you have been warned by your doctor that you have an intolerance to some sugars, check with your doctor before taking allopurinol. How to take Allopurinol doctor. If you have any doubts, you should consult your doctor or pharmacist. Allopurinol should be taken after meals with 1 glass of water. The recommended daily dose is 100-900 mg. Start treatment with allopurinol, usually at a low dose, gradually increasing to the optimal maintenance dose that meets the needs of the patient. If you are an elderly patient or have liver or kidney failure, your doctor may prescribe a lower dose or increase the interval between taking allopurinol. If you are on dialysis 2-3 times a week, your doctor may prescribe a dose of 300-400 mg to be taken immediately after the dialysis session.
The rash may progress, spreading throughout the body with the appearance of large blisters and accompanied by detachment of the epidermis. These severe skin reactions are more common among Han Chinese or Thais.
Children under 15:
The daily maintenance dose is usually 100-400 mg.
If you have taken more Allopurinol than recommended
If you have taken more Allopurinol than recommended, contact your doctor or go to the nearest hospital. Take the medicine package with you. Overdose symptoms are nausea, vomiting, diarrhea and dizziness.
If you forget to take Allopurinol
If you forget to take your next dose, take it as soon as you remember.
If it is time for your next allopurinol dose, skip the missed dose.
Do not take a double dose to make up for a missed one.
If you stop taking Allopurinol
You should talk to your doctor before stopping allopurinol.
If you have any further questions about taking this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, allopurinol can cause side effects, although not everybody gets them. These symptoms include:
Hypersensitivity
Uncommon side effects (may affect up to 1 in 100 people)
If you experience an allergic reaction, stop taking allopurinol immediately and contact your doctor or the nearest hospital.
These symptoms include:
- exfoliative dermatitis, furunculosis and stomatitis
- very rare symptoms such as sudden wheezing, anxiety and tightness in the chest and collapse
Rare side effects ( may affect up to 1 in 1000 people )
- fever, chills, headache, muscle aches (flu-like symptoms) and general malaise.
- severe allergic reactions, including fever, skin rash, joint pain, abnormal blood and liver tests, which are signs of multiple organ dysfunction.
- Bleeding from lips, eyes, mouth, nose and genitals.
- Any changes in the skin, such as sores in the mouth, throat, nose, genitals, conjunctivitis (red and swollen eyes), blistering and desquamation of the epidermis throughout the body.
Do not take more allopurinol than prescribed by your doctor.
Other possible side effects
Uncommon side effects (may affect up to 1 in 100 people)
- nausea and vomiting
- violation of liver tests
Rare side effects (may affect up to 1 in 1000 people)
- liver problems such as inflammation of the liver
Very rare side effects ( may affect up to 1 in 10,000 people )
- disorders of the hematopoietic system, which may lead to bruising from minor exposure or sore throat or other symptoms of infection. These symptoms often appear in patients with impaired liver or kidney function. In this case, you should immediately consult a doctor.
- lymph node involvement
- high temperature
- presence of blood in the urine (hematuria)
- elevated blood cholesterol level (hyperlipidemia)
- feeling generally unwell or feeling weak
- weakness, numbness, unsteadiness when standing, feeling unable to make voluntary muscle movements (paralysis) or loss of consciousness
- headache, dizziness, drowsiness or blurred vision
- chest pain (angina pectoris), high blood pressure or weak pulse
- male infertility or erectile dysfunction
- breast enlargement in both men and women
- bowel dysfunction
- taste disorders
- cataract
- hair loss or discoloration
- depression
- disorders of voluntary coordination of muscular movements (ataxia)
- tingling, tickling and burning sensation (paresthesia)
- swelling of the lower extremities, especially in the ankles.
- impaired glucose tolerance. If this occurs, your doctor will need to have your blood glucose checked periodically.
These symptoms often appear in patients with impaired liver or kidney function. In this case, you should immediately consult a doctor.
If you experience any serious side effects or side effects not listed in this package leaflet, contact your doctor or pharmacist.
Reporting side effects
If you notice any side effects, tell your doctor, pharmacist or pharmacist, including any side effects not listed in this package insert. You can also report side effects to Arpimed LLC by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Drugs and Medical Technologies named after. Academician E.Gabrielyan, by going to the website www.pharm.am in the section “Report a side effect of a drug” and fill out the form “Map of reporting a side effect of a drug”. Scientific center hotline: +37410237665; +37498773368
How to store Allopurinol
- The drug should be stored out of the reach of children, at a temperature not exceeding 25 0 C, in the original packaging.
