What is hematopoietic cell transplantation? How does it work? What are the key benefits and risks? Get a thorough overview of this medical treatment.

Understanding Hematopoietic Cell Transplantation

Hematopoietic cell transplantation (HCT), also known as bone marrow transplantation, is a medical procedure that replaces damaged or destroyed bone marrow with healthy stem cells. This treatment is primarily used for patients with certain types of cancer, such as leukemia, lymphoma, and multiple myeloma, as well as other diseases that affect the blood and immune system.

The HCT Procedure

The HCT process typically involves several steps:

1. Stem Cell Collection: The patient’s own stem cells (autologous HCT) or cells from a donor (allogeneic HCT) are collected through a process called apheresis, where blood is drawn and the stem cells are separated and collected.
2. Conditioning Regimen: The patient undergoes a conditioning regimen, which typically involves high-dose chemotherapy and/or radiation therapy, to destroy the existing diseased or abnormal cells in the bone marrow.
3. Stem Cell Infusion: The collected stem cells are then infused into the patient’s bloodstream, where they travel to the bone marrow and begin to grow and replace the damaged cells.
4. Engraftment: Over the next few weeks, the transplanted stem cells begin to produce new, healthy blood cells, a process known as engraftment.

Benefits of Hematopoietic Cell Transplantation

HCT can provide several benefits for patients with certain medical conditions:

• Improved Survival Rates: For many types of blood cancers, HCT can significantly improve the patient’s chances of long-term survival and remission.
• Restoration of Healthy Blood and Immune System: The transplanted stem cells can help restore the patient’s normal blood cell production and immune function.
• Treatment of Genetic Disorders: HCT can be used to treat certain genetic disorders, such as sickle cell disease and severe combined immunodeficiency (SCID).

Risks and Complications of HCT

While HCT can be a highly effective treatment, it is also associated with several risks and potential complications:

• Infection: Patients undergoing HCT are at a high risk of developing infections due to their weakened immune system.
• Graft-Versus-Host Disease (GVHD): In allogeneic HCT, where the stem cells come from a donor, the transplanted cells may recognize the patient’s body as foreign and attack it, leading to GVHD.
• Organ Damage: The conditioning regimen used before the transplant can damage the patient’s organs, such as the lungs, liver, or kidneys.
• Relapse: In some cases, the underlying disease may return after the transplant, requiring additional treatment.

Advancements and Future Developments in HCT

The field of hematopoietic cell transplantation is continuously evolving, with ongoing research and advancements in various areas:

• Improved Donor Matching: Advances in genetic testing and donor registries are helping to improve the chances of finding a suitable donor for allogeneic HCT.
• Novel Conditioning Regimens: Researchers are exploring new conditioning regimens that are less toxic and better targeted to the underlying disease.
• Emerging Therapies: Innovative treatments, such as chimeric antigen receptor (CAR) T-cell therapy, are being integrated with HCT to enhance its effectiveness.
• Expanded Indications: HCT is being studied for the treatment of an increasing number of diseases, including autoimmune disorders and solid tumors.

Selecting the Appropriate HCT Approach

The decision to undergo HCT and the choice between autologous or allogeneic transplantation depends on several factors, including the patient’s underlying condition, age, overall health, and the availability of a suitable donor. The healthcare team, including oncologists, hematologists, and transplant specialists, will work closely with the patient to determine the most appropriate HCT approach.

Importance of Comprehensive Care and Support

Undergoing HCT is a complex and challenging process, both physically and emotionally. Patients and their families require a comprehensive support system, including access to specialized medical care, psychological counseling, and community resources, to navigate the various stages of the transplant process and achieve the best possible outcomes.

Hydroxylating Conversion Treatment – PROSOCO HCT

Hydroxylating conversion treatment for marbles & limestone

Hydroxylating conversion treatment for marbles & limestone

Description

PROSOCO Conservare® Hydroxylating Conversion Treatment (HCT) is a two-component, waterborne treatment which protects and strengthens deteriorating carbonate building stones such as marble, limestone, dolomite and travertine. HCT (patents pending) dramatically increases the resistance of marble and limestone surfaces to acid rain, air pollution, and normal weathering.

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Vauncele Pearson, 14 years of service

HCT

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Features

• Allows treated stone to become resistant to acid rain.
• Dramatically reduces dissolution of carbonate stones in acid rain.
• Does not form a film.
• Treated surfaces retain natural water vapor permeability.
• No gloss or yellowing; UV stable.

Technical Data

• SHELF LIFE1 year in tightly sealed, unopened container
• VOC CONTENTNon-applicable
• FORMClear, colorless liquid; slight odor
• Ph5.0 (+/- 0.2)
• COVERAGE RATE50-80 sq ft/gal. See Product Data Sheet for specific variations per substrate.
• FREEZE POINT32° F (0° C)
• FLASH POINTNon-applicable
• TOTAL SOLIDSNon-applicable
• WT/GAL8. 39 lbs
• AVAILABLE SIZES5-gal

OVERVIEW

Conservare Hydroxylating Conversion Treatment (HCT) is a novel, two-component, waterborne treatment which protects and strengthens deteriorating carbonate building stones such as marble, limestone, dolomite and travertine. HCT (patents pending) forms a stable, well-adhered, hydroxylated, conversion layer on carbonate mineral grains. This conversion layer dramatically increases the resistance of marble and limestone surfaces to acid attack, and improves the ability of a variety of chemical compositions to react with or bond to such surfaces.

“HCT Programs”

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HOME AND COMMUNITY BASED TREATMENT

Children’s Home and Community Based Treatment (HCT)

HCT is a home-based behavioral health treatment for youth and families in need of treatment more intensive than outpatient therapy. Services are delivered by a team including a master’s level Clinician and bachelor’s level Behavioral Health Professional (BHP), providing individual and family therapy and support, parenting education, behavior management, after-hours phone support, and collaboration with case managers, psychiatrists and other treatment team members to ensure the most effective treatment. Teams provide an average of 5 to 20 hours per week of treatment for a duration of 6-9 months.

Pathways utilizes a multi-systemic approach with the family to establish a comprehensive support network including Pathways staff, extended family, friends, neighbors, case managers, school personnel, and other professionals.  Both individual and family services are available as well as sibling work. These services are delivered in client homes, schools and at various community sites utilizing a family systems approach to maximize parental strengths in order to support effective family management. With Child and Family Behavioral Health Treatment services, the Clinician and BHP work to honor the authority of the parent(s) in the home setting and use clear directives when necessary.

Pathways’ model of focusing on the family system rather than solely on the individual child’s needs and behaviors helps to break generational patterns, which benefit the entire family system.

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Children’s Virtual Residential Program (VRP)Consistent with the call for community-based, least-restrictive alternatives, Pathways of Maine's Virtual Residential Program© was created to meet the needs of an underserved subset of children and adolescents with mental illnesses: those with emotional disturbances so severe that they are at imminent risk of out-of-home placement. VRP is a family-centered and strength-based intervention that combines the structure of residential programs with the benefits of in-home efficacy. Utilizing a mix of theoretical perspectives and therapies, VRP targets multiple-determinates of problems faced by the youth and their families. VRP provides families, schools, and communities with a diversion alternative to unnecessary out-of-home placements and/or to expedite successful step-down of youth following residential or psychiatric placements. 
All services are delivered in the client's home and community, allowing families the opportunity to address challenges in the environment in which they are most likely to occur. Interventions include behavior management, individual and family counseling, coordination with case management, crisis intervention, medication monitoring, parenting skills training and education. When appropriate, VRP staff will work with alternative education programs, to include on-site assistance, after school transition services and education/vocational planning. The average intensity of VRP services initially is thirty-five hours per week, with focus on defusing imminent risk factors and implementing crisis stabilization plans. Service delivery is designed to be flexible and available on a 24 hour, seven days a week basis. Intervention intensity is initially high, depending on the needs of the youth and family. Service intensity is stepped down as soon as clinically possible (typically within the first 2-3 weeks) to an average of 25 hours per week.  The intensity of the service is further stepped down as the youth and family achieve their individualized goals and greater stability. Step-down services are available to transition families toward less restrictive services at the earliest possible opportunity. 
As with most residential programs, the Virtual Residential Program utilizes a treatment team approach in the planning of all services. The VRP Treatment Team, including the client, referring agency representative and parent/guardian, establish the Virtual Residential Schedule, which individualizes daily routines and integrates treatment and behavior management components. The Team also introduces the Five-Phase System, which outlines the youth's goals, responsibilities and privileges while in each of the program phases: Orientation, Acceptance, Working, Consistency and Graduation.

Filorga NCTF-135 – preparations, composition, price, description

Filorga NTFC – French line of preparations based on hyaluronic acid for biorevitalization and mesotherapy. The products moisturize the skin, stimulate the production of natural collagen, provide a lifting effect, eliminate mimic wrinkles and increase skin elasticity.

Used in services

Facial Mesotherapy

Mesotherapy is an injection procedure designed for point impact on a problem area of ​​the body. This method is used to rejuvenate…

Eye mesotherapy

Periorbital mesotherapy helps to get rid of dark circles under the eyes and smooth wrinkles. Also, with the help of the procedure, you can reduce swelling …

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Product line

The Filorga nctf product line includes three products for anti-aging treatments:

• Filorga NCTF 135 innovative – with a concentration of hyaluronic acid 0.25 mg. It is used to prevent photoaging, eliminate fine wrinkles in patients under 30 years of age.
• Filorga NCTF 135 HA fortified – 5 mg. It perfectly copes with the correction of rosacea in patients aged 30-35 years, eliminates skin laxity.
• Filorga NCTF 135 HA+ Extra Enriched – 10mg. Designed for procedures for patients aged 30+. It is used to combat the pronounced signs of aging.

Filorga Gels 135 are complete balanced cocktails. In addition to hyaluronic acid, they include: vitamins, coenzymes, antioxidants, amino acids. Filorga injections are made in the areas of the face, neck and décolleté, décolleté, neck and face. The beautician selects the type of drug individually. So, for the prevention of photoaging, an innovative Filorga gel is used, and for the correction of pronounced wrinkles, an extra-enriched gel is used.

To achieve the best effect, cosmetologists recommend taking a course of Filorga meso of 4-5 procedures with an interval of 14-20 days.

Indications and contraindications

Indications:

• mimic and deeper wrinkles;
• laxity of the skin;
• redness and rosacea;
• decreased moisture and elasticity, dry skin;
• acne, post-acne scarring;
• change in complexion.

Contraindications:

The procedure is not recommended in the following cases:

• malignant neoplasms in the body;
• inflammatory processes and diseases in acute form;
• blood diseases;
• allergy to drug components;
• scars of facial skin changes of mild and moderate severity

Analogs of the drug:

• HYALREPAIR 04/06/08 – Russia
• Filorga NCTF 135 HA – France
• MesoWharton P199 – South Korea
• MesoXantin F199 – USA
• MesoSculpt C71 – South Korea

Procedure progress

The procedure will take 30-50 minutes. The cosmetologist performs step-by-step manipulations:

• interview of the patient, assessment of the skin condition and selection of the drug.
• removal of cosmetics from the skin of the face;
• application of an anesthetic gel or cream;
• drug administration;
• post-procedural antiseptic treatment;
• application of a soothing and anti-inflammatory agent.

Clinics

Losartan and Hydrochlorothiazide | Memorial Sloan Kettering Cancer Center

Adult Medication

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Hyzaar

Brand names: Canada

ACT Losartan/HCT; Apo-Losartan/HCTZ; Auro Losartan HCT; Hyzaar; Hyzaar DS; JAMP-Losartan HCTZ; Losartan-HCT; Losartan-HCTZ; Mint-Losartan/HCTZ; Mint-Losartan/HCTZ DS; Mylan-Losartan/HCTZ; PMS-Losartan/HCTZ; Sandoz-Losartan HCT; Sandoz-Losartan HCT DS; Teva-Losartan/HCTZ

Warning

• Not to be taken by pregnant women. The use of the drug during pregnancy may cause birth defects or intrauterine death of the child. If you become pregnant or plan to become pregnant while taking this drug, contact your doctor immediately.

What is this drug used for?

• Used to treat high blood pressure.
• This drug is used to reduce the chance of a stroke in people with high blood pressure and heart conditions such as left ventricular hypertrophy. This drug may not reduce the chance of stroke in black patients with these conditions.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you are allergic to sulfonamides.
• while taking dofetilide.
• When unable to urinate.
• If you are dehydrated, consult your doctor.
• If you are taking a medicine containing aliskiren if you have diabetes or kidney disease.

This list of drugs and conditions that may interact unfavorably with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving and other activities that require increased attention until you see how this drug affects you.
• To reduce the risk of dizziness or loss of consciousness, get up slowly from a lying or sitting position. Walking up and down stairs should be done with care.
• If you have high blood sugar (diabetes), you should check your blood sugar regularly.
• Check your blood pressure as directed.
• Perform blood tests as directed by your doctor. Consult with your doctor.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• If you are using a salt substitute containing potassium, a potassium-sparing diuretic, or a potassium supplement, check with your doctor.
• If you are on a salt-free or low-salt diet, please consult your doctor.
• Talk to your doctor before taking an over-the-counter drug that can raise blood pressure. These drugs include cough and cold medicines, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, and some natural products.
• Check with your doctor before using alcohol, marijuana or other forms of cannabis, or prescription or over-the-counter drugs that can slow you down.
• Caution should be exercised in hot weather and during vigorous activity. Drink plenty of fluids to prevent dehydration.
• Tell your doctor if you have excessive sweating, fluid loss, vomiting, or loose stools. This can lead to a decrease in blood pressure.
• If you are taking cholestyramine or colestipol, talk with your pharmacist about how to take them with this drug.
• Watch for gout attacks.
• This drug can cause high cholesterol and triglyceride levels. Consult your doctor.
• If you have lupus, this drug may turn on lupus or make it worse. If any new symptom occurs or symptoms worsen, contact your healthcare provider immediately.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• Tell your doctor if you are breastfeeding. It is necessary to consult whether the drug poses any risk to the child.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor or get medical help right away if you have any of the following signs or symptoms that could be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of high blood sugar such as confusion, drowsiness, unusual thirst and hunger, increased urination, flushing, rapid breathing, and fruity breath.
• Signs of kidney problems, including not passing urine, changes in the volume of urine, blood in the urine, or rapid weight gain.
• Signs of fluid and electrolyte imbalances such as mood changes, confusion, muscle pain or weakness, fast or irregular heart rate, severe dizziness or loss of consciousness, extreme thirst, seizures, feeling very tired or weak, decreased appetite, inability to urinate or change in the amount of urine produced, dry mouth, dry eyes, severe nausea or vomiting.
• Swelling of the hands or feet.
• This drug may cause certain eye problems. If left untreated, these problems can lead to long-term vision loss. In cases where such eye problems occurred, symptoms such as blurred vision or eye pain usually appeared in the period from the first hours to the first weeks after the start of the drug. If you experience these symptoms, contact your doctor immediately.
• In rare cases, the use of hydrochlorothiazide has been associated with the development of certain types of skin cancer. Protect your skin from the sun and have skin exams as directed by your doctor. If there is a change in the color or size of a birthmark, or any new or changing skin tumors or growths, contact your healthcare provider immediately.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Dizziness.
• Signs of a cold.
• Back pain.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• Take this drug with or without food.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.
• This drug may cause frequent urination. This can lead to sleep disturbances, so try not to take the drug shortly before going to bed.
• Drink plenty of non-caffeinated fluids, unless your doctor tells you to drink less fluids.

What if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
• The lid must be tightly closed.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General drug information

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options.