Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate?

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Open Forum Infect Dis. 2022 Aug; 9(8): ofac413.

Published online 2022 Aug 11. doi: 10.1093/ofid/ofac413

Author information Article notes Copyright and License information Disclaimer

To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Potential conflicts of interest.
The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

1.
Geng C, Prokesch BC, Vemulapali R. Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate. Open Forum Infect Dis 2022; 9:ofac165. [PMC free article] [PubMed] [Google Scholar]

2.
Spohn G, Scarlato V. Motility, chemotaxis, and flagella. In: Mobley HLT, Mendz GL, Hazell SL, eds. Chapter 21: Helicobacter pylori: physiology and genetics. Washington, DC: ASM Press; 2001. [PubMed] [Google Scholar]

3.
Skene C, Young A, Every A, Sutton P. Helicobacter pylori flagella: antigenic profile and protective immunity. FEMS Microbiol Immunol 2007; 50:249–56. [PubMed] [Google Scholar]

4.
Ley RE, Gewirtz AT. Corralling colonic flagellated microbiota. N Engl J Med 2016; 375:85–7. [PubMed] [Google Scholar]

5.
Kunin CM, Tong HH, Bakaletz LO. Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp. Infect Immun 1995; 63:1796–9. [PMC free article] [PubMed] [Google Scholar]

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Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate? | Open Forum Infectious Diseases

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Calvin M Kunin

Calvin M Kunin

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Open Forum Infectious Diseases, Volume 9, Issue 8, August 2022, ofac413, https://doi. org/10.1093/ofid/ofac413

Published:

11 August 2022

Article history

Received:

29 July 2022

Editorial decision:

05 August 2022

Accepted:

09 August 2022

Published:

11 August 2022

Corrected and typeset:

22 August 2022

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To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Notes

Potential conflicts of interest. The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

1

Geng

C

,

Prokesch

BC

,

Vemulapali

R

.

Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate

.

Open Forum Infect Dis

2022

;

9

:

.

2

Spohn

G

,

Scarlato

V

. Motility, chemotaxis, and flagella. In:

Mobley

HLT

,

Mendz

GL

,

Hazell

SL

, eds.

Chapter 21: Helicobacter pylori: physiology and genetics

.

Washington, DC

:

ASM Press

;

2001

.

3

Skene

C

,

Young

A

,

Every

A

,

Sutton

P

.

Helicobacter pylori flagella: antigenic profile and protective immunity

.

FEMS Microbiol Immunol

2007

;

50

:

249

–

56

.

4

Ley

RE

,

Gewirtz

AT

.

Corralling colonic flagellated microbiota

.

N Engl J Med

2016

;

375

:

85

–

7

.

5

Kunin

CM

,

Tong

HH

,

Bakaletz

LO

.

Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp

.

Infect Immun

1995

;

63

:

1796

–

9

.

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]

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90,000 Helicobacter pylori. Who had it, how was it treated?

Helicobacter pylori. At …

Jun 18, 2018 02:59 PM

31 replies

Last –

May 12, 05:40 Go to

June 18, 2018, 15:13

#1

June 18, 2018, 15:15

900 02 #2

June 18, 2018, 03:27 PM

#3

June 18, 2018, 16:32

#4

Guest

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

18 June 2018 16:52

#5

18 June 2018 17:00

#6

9 0055 June 18, 2018 06:11 PM

#7

Guest

By the way, even the doctor told me this. You stuff yourself with strong antibiotics, and the next day you pick up this bacteria again in a cafe … With this helik, in general, everything is still not completely clear.

18 June 2018 20:19

#8

18 June 2018 21:29

#9

90 077 30 August 2018, 00:26

#10

Irina

Today I had an endoscopy, they did a test for Helicobacter pylori and it turned out to be sharply positive (three pluses). After tomorrow I will go to the gastroenterologist with the analysis, probably. prescribe antibiotics. Who faced similar? How was the treatment? What were the symptoms? Did your hair fall out? 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9January 11, 2019 Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

January 17, 2019 00:01

#13

February 21, 2019 12:40

#14

Evgenia

hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

September 22, 2019 12:05

#16

February 05, 2020 17:38

#17

Y awn

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

August 04, 2020, 19:58

#18

Guest

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively.

March 07, 2021 12:37

#19

February 24, 2022 16:12

#20

Y awn

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively. 15 August 2022 I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i. e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

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December 08, 2022, 09:46

#24

February 06, 14:03

#25

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already crying… fictional stories

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March 21, 08:23

#28

Guest

“My friend was treated with strong antibiotics for a month.”
And that her friend did not have the mind to be treated with propolis tincture? Propolis is much more effective than all antibiotics and without any side effects!
Doctors won’t prescribe you propolis, of course. They stuff you with different things

March 22, 17:59

#29

Guest

Good afternoon! And how to be treated with propolis tincture? What are the proportions?

May 10, 10:46 AM

#30

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already bursting into tears ….

Attention

May 12, 05:40

#31

Guest

You will be prescribed everything by a doctor .. There are antibiotics and a bunch of other drugs. Treatment for a month – then repeat. It is necessary to treat the whole family – to be honest, because. eat and drink from the same glasses. Do not treat – the next stage is cancer..

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Helicobacter pylori bacterium, how to treat?

Helicobacter bacterium . ..

September 07, 2016, 11:15

42 responses

Last –

July 06, 2021, 09:55 Go to

September 07, 2016, 12:25

#1

September 07, 2016, 12:29 9000 3

#2

September 07, 2016, 12:29

#3

September 07, 2016 12:36

#4

September 07, 2016 13:19

#5

robicheva

I was treated with both de-nol and ulcavis, but I did not see any difference in effect.

September 07, 2016, 13:21

#6 0647 September 07, 2016, 02:41 PM

#8

Guest

20% propolis was advised. .. The tests were in the clinic..positive. Also ginger 2 hours before meals with tea.. Nothing else helps.. Again it comes back.

September 07, 2016, 14:50

#9

September 07, 2016 03:07 PM

#10

September 07, 2016 04:28 PM

9 0002 #11

Guest

The same yaytsa, only in profile, not even import substitution.
The active substance is identical, the difference in the amount is 0.3%.
The problem is rather the presence of resistant strains, and a shorter “therapeutic window” than SOME bismuth-free drugs used in multicomponent regimens or as mono(-antimicrobial-) therapy.
Helic is an opportunistic pathogen, in minimal quantities it is present in 90% of those living near rivers, wetlands.
If there is a lot of it, bismuth preparations and other AMHT have the function of “buying time” (treatment of the main metabolic defect, chronic burn or frostbite of the upper gastrointestinal tract, etc. .).
The term “eradication therapy”, which has taken root in medicine, is somewhat incorrect; eradication is significant in terms of removal from the bloodstream, submucosal layers, cellular spaces in various microbial associations, and not just from the body (intestinal lumen, mucosal surface).

September 07, 2016, 16:29

#12

Guest

20% propolis advised… Tests were in the clinic..positive Also ginger 2 hours before meals with tea.. Nothing else helps. .It comes back again.

September 07, 2016, 16:29

#13

robicheva

The doctor prescribed de-nol for me, but after completing the course of treatment with this medicine, I didn’t get rid of the problems, because as it turned out, helicobacter was only a complex of drugs , including antibiotics can be cured. Already again after a few months, when it became clear that I had not got rid of the problem, I was prescribed De-nol, only in combination with antibiotics and an inhibitor. And in the pharmacy, my favorite pharmacist advised Ulcavis, it is much cheaper.

September 07, 2016, 18:46

#14

September 07, 2016, 21:20

#15

roksana.visloukhova

Significantly, as much as almost 2 times.

September 07, 2016, 09:37

#16

September 08, 2016, 08:25

#17

roksana.visloukhova

Significantly, as much as almost 2 times.

September 08, 2016, 11:32 AM

#18

Lyusechka Ionova

Is it possible to save on health?

September 08, 2016, 15:26

#19

roksana.visloukhova

Yes, look at the composition: bismuth tripotassium dicitrate 303.03 mg, excipients: corn starch ny – 72. 17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate

September 08, 2016, 20:17

#20

Lusechka Ionova body substances: corn starch – 72.17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate
Really almost identical medicines…. But de-nol has more bismuth!

September 09, 2016, 11:35

#21

September 09, 2016, 16:43

#22

robicheva

The main thing is that it helps!

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September 09, 2016, 21:09

#23

September 10, 2016, 08:27

#24

September 11, 2016 11:29 AM

#25

September 11, 2016, 04:53 PM

#26

Lyusechka Ionova

As far as I know, you still need to follow a strict diet in addition to drugs

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September 11, 2016, 18:57 2 Of course, this is one of the main conditions for recovery, and only then, along with the diet, taking medication.

September 12, 2016, 08:48

#28

Lyusechka Ionova

Has your sister been tested?

September 12, 2016, 17:49

#29

September 12, 2016, 20:42

How could they prescribe medicines for her without the necessary tests?

September 13, 2016 09:09 AM

#31

September 13, 2016 01:30 PM

#32

September 13, 2016 03:19 PM

#33

September 16 20 16, 18:03

#34

Lyusechka Ionova

This Fine! Only now I doubt that I only need Ulcavis, especially in the analyzes this terrible bacterium! It is necessary to clarify with the doctor again how we will destroy it!

September 16, 2016, 19:40

#35

October 03, 2016, 13:45

#36

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January 03, 2017, 23:50

#38 900 03

Lyusechka Ionova

I don’t know anything about this medicine, I read that this bacterium is usually treated with De-nol. Has anyone been treated with Ulcavis?

September 18, 2017 02:37 PM

#39

October 11, 2017 01:12 PM

#40

December 06, 2017, 15:04

#41

Guest

Proton pump inhibitor + metronidazole + antibiotic. Wash all utensils with soap and disinfect daily. I drank a week, or 10 days, I forgot about a ten-year gastritis. I read the treatment regimen on the Internet, since the gastroenterologist, an old aunt, does not read anything except serials, and I have never heard about the treatment of Helicobacter. It was in 2008.

September 02, 2018 11:26 am

#42

April 08, 2019. a few months later, when it became clear that I had not got rid of the problem, I was prescribed De-nol, only in combination with antibiotics and an inhibitor.