What is the role of bismuth subsalicylate in suppressing Helicobacter pylori infection. How does the salicylate component affect H. pylori flagella. Why is flagella motility important for H. pylori colonization. What are the immune system’s protective mechanisms against flagellated bacteria. How does salicylate impact flagellin synthesis in gram-negative bacteria.

The Unexpected Discovery: Bismuth Subsalicylate’s Effect on H. pylori

In a recent study by Geng et al., published in Open Forum Infectious Diseases, researchers made an intriguing observation regarding the suppression of drug-resistant Helicobacter pylori infection using bismuth subsalicylate. This finding has sparked discussions about which component of the medication – bismuth or salicylate – is primarily responsible for its efficacy against H. pylori.

The Crucial Role of Flagella in H. pylori Colonization

H. pylori’s ability to colonize the human gastric mucosa is largely dependent on its flagella-driven motility. This bacterial appendage plays a vital role in the pathogen’s survival and proliferation within the stomach environment.

Evidence Supporting Flagella’s Importance

• Studies have shown that mice immunized with vaccines targeting H. pylori flagella experienced significantly reduced colonization rates.
• The motility provided by flagella allows H. pylori to navigate through the gastric mucus layer and reach the epithelial surface.
• Flagella also help the bacteria resist the constant flow of gastric contents, enabling them to establish a stable niche.

The Immune System’s Defense Against Flagellated Bacteria

Our immune system has evolved various mechanisms to protect against flagellated microbiota, particularly in the colon. These defenses are crucial in maintaining gut homeostasis and preventing pathogenic colonization.

Key Immune Components

1. Toll-like receptor 5 (TLR5): This receptor specifically recognizes flagellin, the main protein component of bacterial flagella.
2. NOD-like receptor 4 (NLRC4): Upon detecting flagellin, this receptor protein activates the inflammasome, triggering an inflammatory response.

Salicylate’s Impact on Bacterial Flagella

The salicylate component of bismuth subsalicylate has been found to have a significant effect on bacterial flagella, particularly in gram-negative bacteria like H. pylori.

Mechanism of Action

Salicylate acts by reversibly blocking the synthesis of flagellin and flagella in enteric gram-negative bacteria. This inhibition may serve a dual purpose:

• Reducing bacterial motility, thereby hindering colonization
• Potentially protecting against an inflammatory response by preventing flagellin recognition by the immune system

The Salicylate Hypothesis: A New Perspective on Bismuth Subsalicylate’s Efficacy

Given the evidence supporting salicylate’s effect on bacterial flagella, it is proposed that the salicylate component of bismuth subsalicylate may be an active ingredient against H. pylori. This hypothesis challenges the traditional view that bismuth alone is responsible for the medication’s antimicrobial properties.

Implications for Future Research

This new perspective opens up several avenues for further investigation:

• Comparative studies of bismuth compounds with and without salicylate
• In-depth analysis of salicylate’s effects on H. pylori flagella formation and function
• Exploration of potential synergistic effects between bismuth and salicylate

Potential Applications Beyond H. pylori Treatment

The insights gained from studying salicylate’s effect on H. pylori flagella could have broader implications for treating other flagellated bacterial infections.

Possible Areas of Application

• Development of novel antimicrobial strategies targeting bacterial motility
• Design of anti-inflammatory therapies that modulate flagellin-induced immune responses
• Creation of vaccines targeting bacterial flagella components

Challenges and Considerations in Salicylate-Based Treatments

While the potential of salicylate in treating H. pylori infections is promising, several factors need to be considered before its widespread application.

Key Considerations

1. Dosage optimization: Determining the ideal concentration of salicylate for maximum efficacy without adverse effects
2. Resistance development: Assessing the potential for H. pylori to develop resistance to salicylate-based treatments
3. Side effects: Evaluating any potential side effects of long-term salicylate use, particularly on the gastrointestinal system
4. Interactions: Investigating possible interactions between salicylate and other medications commonly used in H. pylori treatment regimens

The Future of H. pylori Treatment: Integrating New Insights

The hypothesis proposing salicylate as an active component against H. pylori opens up new possibilities for improving treatment strategies. As research in this area progresses, we may see a shift in how bismuth subsalicylate and similar compounds are used in clinical practice.

Potential Developments

• Formulation of new medications that optimize the ratio of bismuth to salicylate
• Development of targeted therapies that specifically inhibit flagella formation in H. pylori
• Creation of combination therapies that leverage both bismuth’s and salicylate’s unique properties

As we continue to unravel the complexities of H. pylori infection and treatment, the role of salicylate in bismuth subsalicylate presents an intriguing area for further exploration. This new perspective not only challenges our current understanding but also paves the way for innovative approaches in combating this persistent pathogen.

The journey of scientific discovery often leads us down unexpected paths, and the case of bismuth subsalicylate’s efficacy against H. pylori is no exception. By questioning established beliefs and exploring new hypotheses, researchers can unlock novel treatment strategies that may ultimately improve patient outcomes and public health.

As we move forward, it is crucial to maintain an open mind and continue investigating the multifaceted nature of H. pylori infection and its treatment. The potential role of salicylate in suppressing this stubborn pathogen serves as a reminder that sometimes, the answers we seek may be hiding in plain sight, waiting for a fresh perspective to bring them to light.

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate?

• Journal List
• Open Forum Infect Dis
• PMC9394760

As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with,
the contents by NLM or the National Institutes of Health.

Learn more about our disclaimer.

Open Forum Infect Dis. 2022 Aug; 9(8): ofac413.

Published online 2022 Aug 11. doi: 10.1093/ofid/ofac413

Author information Article notes Copyright and License information Disclaimer

To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Potential conflicts of interest.
The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

1.
Geng C, Prokesch BC, Vemulapali R. Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate. Open Forum Infect Dis 2022; 9:ofac165. [PMC free article] [PubMed] [Google Scholar]

2.
Spohn G, Scarlato V. Motility, chemotaxis, and flagella. In: Mobley HLT, Mendz GL, Hazell SL, eds. Chapter 21: Helicobacter pylori: physiology and genetics. Washington, DC: ASM Press; 2001. [PubMed] [Google Scholar]

3.
Skene C, Young A, Every A, Sutton P. Helicobacter pylori flagella: antigenic profile and protective immunity. FEMS Microbiol Immunol 2007; 50:249–56. [PubMed] [Google Scholar]

4.
Ley RE, Gewirtz AT. Corralling colonic flagellated microbiota. N Engl J Med 2016; 375:85–7. [PubMed] [Google Scholar]

5.
Kunin CM, Tong HH, Bakaletz LO. Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp. Infect Immun 1995; 63:1796–9. [PMC free article] [PubMed] [Google Scholar]

Articles from Open Forum Infectious Diseases are provided here courtesy of Oxford University Press

Suppression of Helicobacter pylori Infection With Bismuth Subsalicylate: Was It the Bismuth or the Salicylate? | Open Forum Infectious Diseases

Navbar Search Filter

Open Forum Infectious DiseasesThis issueIDSA JournalsInfectious DiseasesBooksJournalsOxford Academic
Mobile Enter search term

Close

Navbar Search Filter

Open Forum Infectious DiseasesThis issueIDSA JournalsInfectious DiseasesBooksJournalsOxford Academic
Enter search term

Advanced Search

Journal Article

Calvin M Kunin

Calvin M Kunin

Search for other works by this author on:

Oxford Academic

Google Scholar

Open Forum Infectious Diseases, Volume 9, Issue 8, August 2022, ofac413, https://doi. org/10.1093/ofid/ofac413

Published:

11 August 2022

Article history

Received:

29 July 2022

Editorial decision:

05 August 2022

Accepted:

09 August 2022

Published:

11 August 2022

Corrected and typeset:

22 August 2022

Navbar Search Filter

Open Forum Infectious DiseasesThis issueIDSA JournalsInfectious DiseasesBooksJournalsOxford Academic
Mobile Enter search term

Close

Navbar Search Filter

Open Forum Infectious DiseasesThis issueIDSA JournalsInfectious DiseasesBooksJournalsOxford Academic
Enter search term

Advanced Search

To the EDITOR—I read with great interest the publication by Geng et al [1] on their serendipitous observation that bismuth subsalicylate suppressed gastric infection in a patient with drug-resistant Helicobacter pylori. The purpose of this communication is to consider which of the components of the combination, or both, might be responsible for the efficacy of bismuth subsalicylate. The authors have reviewed the potential effects of bismuth. This letter focuses on the ability of the salicylate component to suppress flagella. There is convincing evidence that the motility of H pylori flagella has a key role in the colonization of the human gastric mucosa [2]. Mice immunized with a vaccine targeting H pylori flagella significantly reduced colonization [3]. The immune system has an extensive array of protective mechanisms to corral colonic flagellated microbiota [4]. These include the Toll-like receptor 5 that senses flagellin and the NOD-like receptor 4. On detection of flagellin, this receptor protein activates the inflammasome. Salicylate reversibly blocks the synthesis of flagellin and flagella in enteric gram-negative bacteria and may protect against an inflammatory response [5]. This supports the notion that the salicylate component of bismuth subsalicylate is an active ingredient against H pylori. This hypothesis is offered to stimulate further work in this important field.

Notes

Potential conflicts of interest. The author: No reported conflicts.

The author has submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

1

Geng

C

,

Prokesch

BC

,

Vemulapali

R

.

Successful suppression of drug-resistant Helicobacter pylori infection with bismuth subsalicylate

.

Open Forum Infect Dis

2022

;

9

:

.

2

Spohn

G

,

Scarlato

V

. Motility, chemotaxis, and flagella. In:

Mobley

HLT

,

Mendz

GL

,

Hazell

SL

, eds.

Chapter 21: Helicobacter pylori: physiology and genetics

.

Washington, DC

:

ASM Press

;

2001

.

3

Skene

C

,

Young

A

,

Every

A

,

Sutton

P

.

Helicobacter pylori flagella: antigenic profile and protective immunity

.

FEMS Microbiol Immunol

2007

;

50

:

249

–

56

.

4

Ley

RE

,

Gewirtz

AT

.

Corralling colonic flagellated microbiota

.

N Engl J Med

2016

;

375

:

85

–

7

.

5

Kunin

CM

,

Tong

HH

,

Bakaletz

LO

.

Effect of salicylate on expression of flagella by Escherichia coli and Proteus, Providencia, and Pseudomonas spp

.

Infect Immun

1995

;

63

:

1796

–

9

.

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]

Issue Section:

Correspondence

Download all slides

Advertisement

Citations

Altmetric

More metrics information

Email alerts

Article activity alert

Advance article alerts

New issue alert

In progress issue alert

Receive exclusive offers and updates from Oxford Academic

Citing articles via

• 
  

  
  Latest
  

• 
  

  
  Most Read
  

• 
  

  
  Most Cited
  

Sero-Epidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France

Unexpected Loa loa finding in an asymptomatic patient from The Gambia: A Case Report

Long Term Safety and Tolerability of Omadacycline for the Treatment of Mycobacterium Abscessus Infections

Distribution, trends, and antimicrobial susceptibility of Bacteroides, Clostridium, Fusobacterium, and Prevotella species causing bacteremia in Japan during 2011–2020: A retrospective observational study based on national surveillance data

Microalbuminuria in Perinatally HIV-Infected Children and Adolescents in the United States

Faculty Position Attending Physician

Boston, Massachusetts

DIRECTOR, CENTER FOR SLEEP & CIRCADIAN RHYTHMS

Winston-Salem, North Carolina

Academic Pulmonary Sleep Medicine Physician Opportunity in Scenic Central Pennsylvania

Hershey, Pennsylvania

ACADEMIC SURGICAL PATHOLOGIST

, Vermont

View all jobs

Advertisement

90,000 Helicobacter pylori. Who had it, how was it treated?

Helicobacter pylori. At …

Jun 18, 2018 02:59 PM

31 replies

Last –

May 12, 05:40 Go to

June 18, 2018, 15:13

#1

June 18, 2018, 15:15

900 02 #2

June 18, 2018, 03:27 PM

#3

June 18, 2018, 16:32

#4

Guest

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

18 June 2018 16:52

#5

18 June 2018 17:00

#6

9 0055 June 18, 2018 06:11 PM

#7

Guest

By the way, even the doctor told me this. You stuff yourself with strong antibiotics, and the next day you pick up this bacteria again in a cafe … With this helik, in general, everything is still not completely clear.

18 June 2018 20:19

#8

18 June 2018 21:29

#9

90 077 30 August 2018, 00:26

#10

Irina

Today I had an endoscopy, they did a test for Helicobacter pylori and it turned out to be sharply positive (three pluses). After tomorrow I will go to the gastroenterologist with the analysis, probably. prescribe antibiotics. Who faced similar? How was the treatment? What were the symptoms? Did your hair fall out? 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9January 11, 2019 Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

January 17, 2019 00:01

#13

February 21, 2019 12:40

#14

Evgenia

hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

September 22, 2019 12:05

#16

February 05, 2020 17:38

#17

Y awn

All this nonsense! Every second suffers from helix. Treatment is not required! more organism suffers from antibiotics!

August 04, 2020, 19:58

#18

Guest

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively.

March 07, 2021 12:37

#19

February 24, 2022 16:12

#20

Y awn

I had. Revealed with a strong exacerbation of gastritis. It is necessary to treat. They prescribed antibiotics and a bunch of other drugs. It has been 6 years without recurrence, I am very pleased that I have treated it qualitatively. 15 August 2022 I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i. e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru 9Hello! I was diagnosed with gastritis at the age of 10, and no one had heard of Helicobacter at that time. I constantly suffered from the stomach: pain, nausea, heartburn, etc. After giving birth, my stomach condition only worsened ((very severe pain and constantly nauseous. After 2 years, I decided to take Helicobacter pylori (I looked for a lot of information on the Internet and found out that it is necessary to take it for immunoglobulin ji – this is a sluggish form of Helicobacteriosis, i.e. .. you need to take it for “Helicobacter pylori IgG”, I handed it over in the synlab in our Minsk). CARL!!!! , and this is just 2 months of treatment. Thanks to the herbs. I wish you a speedy recovery. If someone wants to ask a question – write, I will be happy to answer: my mail is ocean-super@mail. ru

Woman.ru experts

• Sadovnikov Ernest

  Psychologist . …

  244 answers

• Arkhipova Maria

  Coach. I work in a personal niche …

  2 answers

• Nina Babanakova

  Nutritionist, consultant on…

  84 answers

• Sergey Katyshev

  Nutritionist

  143 answers

• Oksana Nosachenko

  Psychologist

  37 answers

• Dmitry Olegovich Surotkin

  Psychotherapist

  41 answers

• Vladimir Weiss

  Neopsychologist

  226 answers

• Julia Lekomtseva

  Cosmetologist

  286 answers

• Maria Burlakova

  Psychologist

  391 answers

• Vera Vladimirovna Zolotykh

  Psychologist

  149 answers

December 08, 2022, 09:46

#24

February 06, 14:03

#25

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already crying… fictional stories

• Husband leaves to rest without me

  359 answers

• Is a man reasonable?

  27 answers

• Husband and maternity leaves 2

  404 answers

• 35 years – everything, the limit? Further into the coffin?

  71 answer

March 21, 08:23

#28

Guest

“My friend was treated with strong antibiotics for a month.”
And that her friend did not have the mind to be treated with propolis tincture? Propolis is much more effective than all antibiotics and without any side effects!
Doctors won’t prescribe you propolis, of course. They stuff you with different things

March 22, 17:59

#29

Guest

Good afternoon! And how to be treated with propolis tincture? What are the proportions?

May 10, 10:46 AM

#30

Guest

Yes. A friend was treated with strong antibiotics for a month. It seems to have recovered, as the tests showed. And a month later, a new one. Whether from the husband has caught, whether from the child. I was already bursting into tears ….

Attention

May 12, 05:40

#31

Guest

You will be prescribed everything by a doctor .. There are antibiotics and a bunch of other drugs. Treatment for a month – then repeat. It is necessary to treat the whole family – to be honest, because. eat and drink from the same glasses. Do not treat – the next stage is cancer..

New topics in 3 days: 244 topics

• Is it true that 60 of us..?

  4 answers

• Father’s health problems

  3 answers

• 312

  17 answers

• Feet very swollen

  8 answers

• Is it allowed to take pills?

  1 answer

• Health, what to do?

  5 answers

• Faeces in a smear: how to cure?

  1 answer

• Eating disorder

  2 answers

• Been dizzy for a year

  11 answers

• Pain in the left shoulder blade, what is it?

  6 answers

Popular topics in 3 days: 73,633 topics

• Stop poisoning!

  185 answers

• Doctors and forensic experts, a question for you

  11 answers

• What can you advise for diseases of the joints?

  9 answers

• Feet very swollen

  8 answers

• No period and hair falls out after weight loss

  7 answers 2

  6 answers

• Pain in the left shoulder blade, what is it?

  6 answers

• Health, what to do?

  5 answers

• Can laxatives provoke oncology?

  5 answers

Next topic

Previous topic

• Why do doctors advise everyone to take vitamins with selenium?

  19 answers

Helicobacter pylori bacterium, how to treat?

Helicobacter bacterium . ..

September 07, 2016, 11:15

42 responses

Last –

July 06, 2021, 09:55 Go to

September 07, 2016, 12:25

#1

September 07, 2016, 12:29 9000 3

#2

September 07, 2016, 12:29

#3

September 07, 2016 12:36

#4

September 07, 2016 13:19

#5

robicheva

I was treated with both de-nol and ulcavis, but I did not see any difference in effect.

September 07, 2016, 13:21

#6 0647 September 07, 2016, 02:41 PM

#8

Guest

20% propolis was advised. .. The tests were in the clinic..positive. Also ginger 2 hours before meals with tea.. Nothing else helps.. Again it comes back.

September 07, 2016, 14:50

#9

September 07, 2016 03:07 PM

#10

September 07, 2016 04:28 PM

9 0002 #11

Guest

The same yaytsa, only in profile, not even import substitution.
The active substance is identical, the difference in the amount is 0.3%.
The problem is rather the presence of resistant strains, and a shorter “therapeutic window” than SOME bismuth-free drugs used in multicomponent regimens or as mono(-antimicrobial-) therapy.
Helic is an opportunistic pathogen, in minimal quantities it is present in 90% of those living near rivers, wetlands.
If there is a lot of it, bismuth preparations and other AMHT have the function of “buying time” (treatment of the main metabolic defect, chronic burn or frostbite of the upper gastrointestinal tract, etc. .).
The term “eradication therapy”, which has taken root in medicine, is somewhat incorrect; eradication is significant in terms of removal from the bloodstream, submucosal layers, cellular spaces in various microbial associations, and not just from the body (intestinal lumen, mucosal surface).

September 07, 2016, 16:29

#12

Guest

20% propolis advised… Tests were in the clinic..positive Also ginger 2 hours before meals with tea.. Nothing else helps. .It comes back again.

September 07, 2016, 16:29

#13

robicheva

The doctor prescribed de-nol for me, but after completing the course of treatment with this medicine, I didn’t get rid of the problems, because as it turned out, helicobacter was only a complex of drugs , including antibiotics can be cured. Already again after a few months, when it became clear that I had not got rid of the problem, I was prescribed De-nol, only in combination with antibiotics and an inhibitor. And in the pharmacy, my favorite pharmacist advised Ulcavis, it is much cheaper.

September 07, 2016, 18:46

#14

September 07, 2016, 21:20

#15

roksana.visloukhova

Significantly, as much as almost 2 times.

September 07, 2016, 09:37

#16

September 08, 2016, 08:25

#17

roksana.visloukhova

Significantly, as much as almost 2 times.

September 08, 2016, 11:32 AM

#18

Lyusechka Ionova

Is it possible to save on health?

September 08, 2016, 15:26

#19

roksana.visloukhova

Yes, look at the composition: bismuth tripotassium dicitrate 303.03 mg, excipients: corn starch ny – 72. 17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate

September 08, 2016, 20:17

#20

Lusechka Ionova body substances: corn starch – 72.17 mg; povidone K30 – 18 mg; potassium polycrilin – 23.8 mg; macrogol 6000 – 6 mg; magnesium stearate – 2 mg
And for denol: bismuth tripotassium dicitrate 304.6 mg, excipients: corn starch; povidone K30; potassium polyacrylate; macrogol 6000; magnesium stearate
Really almost identical medicines…. But de-nol has more bismuth!

September 09, 2016, 11:35

#21

September 09, 2016, 16:43

#22

robicheva

The main thing is that it helps!

Woman. ru experts

• Sadovnikov Ernest

  Psychologist ….

  244 answers

• Arkhipova Maria

  Coach. I work in a personal niche …

  2 answers

• Nina Babanakova

  Nutritionist, consultant on…

  84 answers

• Sergey Katyshev

  Nutritionist

  143 answers

• Oksana Nosachenko

  Psychologist

  37 answers

• Dmitry Olegovich Surotkin

  Psychotherapist

  41 answers

• Vladimir Weiss

  Neopsychologist

  226 answers

• Julia Lekomtseva

  Cosmetologist

  286 answers

• Maria Burlakova

  Psychologist

  391 answers

• Vera Vladimirovna Zolotykh

  Psychologist

  149 answers

September 09, 2016, 21:09

#23

September 10, 2016, 08:27

#24

September 11, 2016 11:29 AM

#25

September 11, 2016, 04:53 PM

#26

Lyusechka Ionova

As far as I know, you still need to follow a strict diet in addition to drugs

Non-invented stories

• 90 002
  

  Husband goes on vacation without me

  359 answers

• Is a reasonable person?

  27 answers

• Husband and maternity leave

  150 answers

• I like a married colleague

  404 answers

• 35 years – everything, the limit? Further into the coffin?

  71 replies

September 11, 2016, 18:57 Of course, this is one of the main conditions for recovery, and only then, along with the diet, taking medication.

September 12, 2016, 08:48

#28

Lyusechka Ionova

Has your sister been tested?

September 12, 2016, 17:49

#29

September 12, 2016, 20:42

How could they prescribe medicines for her without the necessary tests?

September 13, 2016 09:09 am

#310003 September 13, 2016 03:19 PM

#33

September 16, 2016 06:03 PM

#34

Liu Ionov’s cut

It’s good! Only now I doubt that I only need Ulcavis, especially in the analyzes this terrible bacterium! It is necessary to clarify with the doctor again how we will destroy it!

September 16, 2016, 19:40

#35

October 03, 2016, 13:45

#36

New themes

• An ideal lover for an older woman

  1 answer

• How to stop communicating with your husband’s relatives often?

  7 answers

• Honey and wormwood (6)

  No answers

• 35 neither children nor husband 903 12

  3 answers

• Husband’s son

  1 answer

January 03, 2017, 23:50

#38

Lyusechka Ionova

I don’t know anything about this medicine, I read that this bacterium is usually treated with De-nol. Has anyone been treated with Ulcavis?

September 18, 2017 02:37 PM

#39

October 11, 2017 01:12 PM

#40

December 06, 2017, 03:04 PM

#41

Guest

Proton pump inhibitor + metronidazole + antibiotic. Wash all utensils with soap and disinfect daily. I drank a week, or 10 days, I forgot about a ten-year gastritis. I read the treatment regimen on the Internet, since the gastroenterologist, an old aunt, does not read anything except serials, and I have never heard about the treatment of Helicobacter. It was in 2008.

September 02, 2018, 11:26

#42

April 08, 2019, 20:45

#42

robicheva

The doctor prescribed de-nol for me, but after completing the course of treatment with this medicine to the end I didn’t get rid of the problems, because as it turned out, Helicobacter pylori can be cured only with a complex of drugs, including antibiotics.