Heparin side effects in elderly: Heparin (Intravenous Route, Subcutaneous Route) Side Effects
Side Effects, Dosage, Uses, and More
Highlights for heparin
- Heparin injectable solution only comes as a generic drug. It doesn’t have a brand-name version.
- Heparin comes in two forms. One is an injectable solution, which you inject under your skin. The other is a solution that’s injected intravenously (into one of your veins). Only your doctor can give you the intravenous form.
- Heparin injectable solution is a blood thinner that’s used to treat and prevent blood clots.
- Low platelet levels warning. This drug can decrease your platelet levels. This is known as heparin-induced thrombocytopenia (HIT), which can eventually lead to the formation of blood clots in your veins. These clots can form even several weeks after you stop taking heparin. Your doctor will check you for low platelet levels.
- Bleeding risk warning. This drug may cause serious bleeding. This happens because this drug reduces your body’s ability to make your blood clot.
Heparin may cause you to bruise more easily. It also may take your body longer to stop bleeding. This can cause death in rare cases. Let your doctor know if you have frequent nosebleeds, unusual bleeding from your gums, periods that are heavier than normal, red or brown urine, or dark or tarry stools. Also let your doctor know if you vomit blood, if your vomit looks like coffee grounds, or if you have headaches, dizziness, or weakness.
Heparin may cause you to bruise more easily. It also may take your body longer to stop bleeding. This can cause death in rare cases. Let your doctor know if you have frequent nosebleeds, unusual bleeding from your gums, periods that are heavier than normal, red or brown urine, or dark or tarry stools. Also let your doctor know if you vomit blood, if your vomit looks like coffee grounds, or if you have headaches, dizziness, or weakness.Heparin is a prescription drug. It comes as a self-injectable solution that you inject under your skin. It also comes as a solution that a healthcare provider injects intravenously (into one of your veins). You can only receive the intravenous form in the hospital.
For the injectable solution, you’ll receive your first injection at a hospital. A healthcare provider will show you how to give yourself the injection. You will give yourself the remaining doses at home.
Heparin injectable solution is only available as a generic drug.
Why it’s used
Heparin is a blood thinner that’s used to treat and prevent blood clots.
These can include venous thrombosis, pulmonary embolism, and peripheral arterial embolism.
How it works
Heparin belongs to a class of drugs called anticoagulants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Heparin works by disrupting the formation of blood clots in your veins. It can prevent blood clots from forming, or stop clots that have already formed from getting larger.
Heparin injectable solution doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects of this drug include:
- bruising more easily
- bleeding that takes longer to stop
- irritation, pain, redness, or sores at the injection site
- allergic reactions, such as hives, chills, and fever
- increased liver enzymes on liver function test results
If these effects are mild, they may go away within a few days or a couple of weeks.
If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Severe bleeding. Symptoms can include:
- bruising more easily
- unexpected bleeding or bleeding that lasts a long time, such as:
- unusual bleeding from your gums
- frequent nosebleeds
- periods that are heavier than normal
- pink or brown urine
- dark, tarry stool (may be a sign of bleeding in your stomach)
- severe bleeding or bleeding that you can’t stop
- coughing up blood or blood clots
- vomit that contains blood or looks like coffee grounds
- headaches
- weakness
- dizziness
- Serious allergic reactions. Symptoms can include:
- skin tissue death at the injection site
- chills
- fever
- rash and hives
- itching
- burning
- shortness of breath
- swelling of your face, lips, throat, or tongue
- Heparin-induced thrombocytopenia. This is low platelet levels caused by heparin use. It can cause new or worsening clots in your blood vessels. These may lead to a stroke or heart attack. Symptoms of new or worsening blood clots can include:
- reddening and swelling of one leg or arm
- coughing up blood
This is low platelet levels caused by heparin use. It can cause new or worsening clots in your blood vessels. These may lead to a stroke or heart attack. Symptoms of new or worsening blood clots can include:Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Heparin injectable solution can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully.
Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with heparin are listed below.
Interactions that can increase your risk of side effects
Taking heparin with certain drugs can increase your risk of bleeding and make you bruise more easily. Examples of these drugs include:
- aspirin
- nonsteroidal anti-inflammatory drugs such as celecoxib, ibuprofen, and naproxen
- antiplatelet drugs such as clopidogrel and dipyridamole
- hydroxychloroquine
- herbal supplements such as ginkgo biloba, fish oil, and garlic
Interactions that can make heparin less effective
When used with heparin, certain drugs can make heparin less effective. Examples of these drugs include:
- digoxin
- tetracycline antibiotics such as doxycycline and minocycline
- nicotine
- nitrates, such as isosorbide, mononitrate, and nitroglycerin
- antihistamines such as diphenhydramine
Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Allergy warning
Heparin can cause a severe allergic reaction. Symptoms can include:
- skin tissue death at the injection site
- chills
- fever
- rash
- hives
- itching
- burning
- shortness of breath
- swelling of your face, lips, throat, or tongue
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Heparin is derived from animal tissue. It should be used with caution in people with a history of allergy to this drug or to pig proteins.
Taking heparin could be fatal (cause death).
Warnings for people with certain health conditions
For people with pig protein sensitivity: Do not take this drug. This drug is made from pork tissue and can cause a life-threatening allergic reaction in people who are sensitive or allergic to other pig proteins.
For people with uncontrolled high blood pressure: You are at an increased risk of bleeding from this drug. Talk to your doctor before using heparin.
For people with bleeding or clotting problems: If you have abnormal bleeding or a condition that puts you at an increased risk of bleeding, using heparin could increase your risk even more. Use heparin with caution.
For people with a history of stomach ulcers or bleeding: If you have active stomach ulcers, you should not use heparin. It could make your ulcers worse and cause dangerous bleeding. If you have a history of stomach ulcers but don’t have active ulcers, using heparin puts you at an increased risk of bleeding.
You should talk to your doctor before using heparin.
For people with kidney disease: If you have severe kidney disease or a history of kidney disease, taking heparin can increase your risk of bleeding. Talk to your doctor before using heparin.
For people with liver disease: If you have severe liver disease or a history of liver disease, taking heparin can increase your risk of bleeding. Talk to your doctor before using heparin.
For people with asthma or sulfite sensitivity: People with asthma are likely to be sensitive to sulfites. Sulfites can cause a life-threatening allergic reaction in some people. Some forms of this drug contain sulfites. Talk to your doctor about using a sulfite-free version of heparin.
Warnings for other groups
For pregnant women: Research in animals has shown negative effects to the fetus when the mother uses heparin. However, there haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should only be used if the potential benefit justifies the potential risk. Ask your doctor if using the preservative-free version of heparin would be better for you than the version that contains benzyl alcohol.
If you become pregnant while taking this drug, call your doctor right away.
For women who are breastfeeding: Heparin is unlikely to pass into breast milk and be absorbed by an infant who is breastfed. Talk to your doctor about the best way to feed your child while you’re taking heparin.
Some forms of heparin contain a preservative called benzyl alcohol. This ingredient can slow down the central nervous system in some infants. It has also caused trouble breathing and changes in the blood chemistry in some infants. These effects can be deadly. If you breastfeed your child, talk to your doctor about preservative-free heparin.
For seniors: If you are older than 60 years, you may be at a higher risk of bleeding.
Heparin also increases your risk of bleeding, so your doctor may start you on a reduced dosage.
For children: This medication has not been studied in children. Dosage recommendations are based on clinical experience.
Newborns and infants should receive preservative-free heparin. The preservative benzyl alcohol has been linked to serious side effects and even death in newborns and infants.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Drug forms and strengths
Generic: Heparin
- Form: injectable solution, preservative-free
- Strengths: 1,000 units/mL, 10,000 units/mL
- Form: injectable solution preserved with benzyl alcohol
- Strengths: 1,000 units/mL, 5,000 units/mL, 10,000 units/mL, 20,000 units/mL
Dosage for deep vein thrombosis and pulmonary embolism
Adult dosage (ages 18–59 years)
- Typical starting dosage: 333 units/kg of body weight injected under your skin.
- Typical maintenance dosage: 250 units/kg of body weight injected under your skin every 12 hours. Change the injection site each time to prevent a blood clot from forming at the injection site.
Child dosage (ages 0–17 years)
Your doctor will determine your child’s dosage based on your child’s condition and medical history.
Senior dosage (ages 60 years and older)
You may be at higher risk of bleeding. Your doctor may start you on a reduced dosage.
Dosage for preventing deep vein thrombosis after surgery
Adult dosage (ages 18–59 years)
- Typical dosage: Your doctor or nurse will give you 5,000 units about 2 hours before your surgery.
- Typical maintenance dosage: 5,000 units injected under your skin every 8–12 hours. You’ll give yourself this dosage for 7 days or until you can start walking.
Child dosage (ages 0–17 years)
Your doctor will determine your child’s dosage based on your child’s condition and medical history.
Senior dosage (ages 60 years and older)
You may be at higher risk of bleeding. Your doctor may start you on a reduced dosage.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Heparin injectable solution is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: You may develop a blood clot, or an existing blood clot could get worse. These blood clots can be fatal (cause death).
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely.
For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body, which could lead to serious bleeding. This can be deadly. Symptoms of an overdose of this drug can include:
- bruising easily
- unexpected bleeding or bleeding that lasts a long time, such as:
- unusual bleeding from your gums
- frequent nosebleeds
- in women: periods that are heavier than normal
- pink or brown urine
- dark, tarry stool (may be a sign of bleeding in the stomach)
- severe bleeding or bleeding that you can’t stop
- coughing up blood or blood clots
- vomit that contains blood or looks like coffee grounds
- headaches
- weakness
- dizziness
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects, such as serious bleeding.
How to tell if the drug is working: You should not develop a blood clot, or the clot you currently have should go away.
Keep these considerations in mind if your doctor prescribes heparin for you.
Self-management
- Your doctor will show you how to give yourself the injection.
- Use this drug only if the solution is clear and the seal is intact. Do not use this drug if the solution is cloudy, discolored, or has particles in it.
Storage
Store heparin at room temperature between 68°F and 77°F (20°F and 25°C).
Refills
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled.
Your doctor will write the number of refills authorized on your prescription.
Travel
When traveling with your medication:
- Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
- Don’t worry about airport x-ray machines. They can’t harm your medication.
- You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
- Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
- You need needles and syringes to take this medication. Check for special rules about traveling with your medication, needles, and syringes.
Clinical monitoring
Your doctor will monitor how well heparin is working for you by doing coagulation or clotting tests. The results of these tests will also help your doctor choose the right dosage of heparin for you.
Your doctor should test you to help make sure you stay safe while you take this drug. These tests check your:
- Kidney function. If your kidneys are not working well, you may have a higher risk of bleeding. Your doctor will monitor your kidneys to make sure this drug is safe for you to take.
- Liver function. If your liver is not working well, you may have a higher risk of bleeding. Your doctor will monitor your liver to make sure this drug is safe for you to take.
- Signs of bleeding. Your doctor may check your platelet and hematocrit levels. They may do a test that checks for blood that may be hidden in your stool. This monitoring helps make sure you don’t bleed too much while you take this drug.
Availability
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Hidden costs
You may need to purchase:
- sterile alcohol wipes
- needles and syringes
- a sharps container (a bin for disposing used needles safely)
There are other drugs available to treat your condition.
Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Side Effects, Dosage, Uses, and More
Highlights for heparin
- Heparin injectable solution only comes as a generic drug. It doesn’t have a brand-name version.
- Heparin comes in two forms. One is an injectable solution, which you inject under your skin. The other is a solution that’s injected intravenously (into one of your veins). Only your doctor can give you the intravenous form.
- Heparin injectable solution is a blood thinner that’s used to treat and prevent blood clots.
It doesn’t have a brand-name version.- Low platelet levels warning. This drug can decrease your platelet levels. This is known as heparin-induced thrombocytopenia (HIT), which can eventually lead to the formation of blood clots in your veins. These clots can form even several weeks after you stop taking heparin. Your doctor will check you for low platelet levels.
- Bleeding risk warning. This drug may cause serious bleeding. This happens because this drug reduces your body’s ability to make your blood clot. Heparin may cause you to bruise more easily. It also may take your body longer to stop bleeding. This can cause death in rare cases. Let your doctor know if you have frequent nosebleeds, unusual bleeding from your gums, periods that are heavier than normal, red or brown urine, or dark or tarry stools. Also let your doctor know if you vomit blood, if your vomit looks like coffee grounds, or if you have headaches, dizziness, or weakness.
Let your doctor know if you have frequent nosebleeds, unusual bleeding from your gums, periods that are heavier than normal, red or brown urine, or dark or tarry stools. Also let your doctor know if you vomit blood, if your vomit looks like coffee grounds, or if you have headaches, dizziness, or weakness.Heparin is a prescription drug. It comes as a self-injectable solution that you inject under your skin. It also comes as a solution that a healthcare provider injects intravenously (into one of your veins). You can only receive the intravenous form in the hospital.
For the injectable solution, you’ll receive your first injection at a hospital. A healthcare provider will show you how to give yourself the injection. You will give yourself the remaining doses at home.
Heparin injectable solution is only available as a generic drug.
Why it’s used
Heparin is a blood thinner that’s used to treat and prevent blood clots. These can include venous thrombosis, pulmonary embolism, and peripheral arterial embolism.
How it works
Heparin belongs to a class of drugs called anticoagulants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Heparin works by disrupting the formation of blood clots in your veins. It can prevent blood clots from forming, or stop clots that have already formed from getting larger.
Heparin injectable solution doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects of this drug include:
- bruising more easily
- bleeding that takes longer to stop
- irritation, pain, redness, or sores at the injection site
- allergic reactions, such as hives, chills, and fever
- increased liver enzymes on liver function test results
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Severe bleeding. Symptoms can include:
- bruising more easily
- unexpected bleeding or bleeding that lasts a long time, such as:
- unusual bleeding from your gums
- frequent nosebleeds
- periods that are heavier than normal
- pink or brown urine
- dark, tarry stool (may be a sign of bleeding in your stomach)
- severe bleeding or bleeding that you can’t stop
- coughing up blood or blood clots
- vomit that contains blood or looks like coffee grounds
- headaches
- weakness
- dizziness
- Serious allergic reactions. Symptoms can include:
- skin tissue death at the injection site
- chills
- fever
- rash and hives
- itching
- burning
- shortness of breath
- swelling of your face, lips, throat, or tongue
- Heparin-induced thrombocytopenia. This is low platelet levels caused by heparin use. It can cause new or worsening clots in your blood vessels. These may lead to a stroke or heart attack. Symptoms of new or worsening blood clots can include:
- reddening and swelling of one leg or arm
- coughing up blood
This is low platelet levels caused by heparin use. It can cause new or worsening clots in your blood vessels. These may lead to a stroke or heart attack. Symptoms of new or worsening blood clots can include:Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Heparin injectable solution can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully.
Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with heparin are listed below.
Interactions that can increase your risk of side effects
Taking heparin with certain drugs can increase your risk of bleeding and make you bruise more easily. Examples of these drugs include:
- aspirin
- nonsteroidal anti-inflammatory drugs such as celecoxib, ibuprofen, and naproxen
- antiplatelet drugs such as clopidogrel and dipyridamole
- hydroxychloroquine
- herbal supplements such as ginkgo biloba, fish oil, and garlic
Interactions that can make heparin less effective
When used with heparin, certain drugs can make heparin less effective. Examples of these drugs include:
- digoxin
- tetracycline antibiotics such as doxycycline and minocycline
- nicotine
- nitrates, such as isosorbide, mononitrate, and nitroglycerin
- antihistamines such as diphenhydramine
Disclaimer: Our goal is to provide you with the most relevant and current information.
However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Allergy warning
Heparin can cause a severe allergic reaction. Symptoms can include:
- skin tissue death at the injection site
- chills
- fever
- rash
- hives
- itching
- burning
- shortness of breath
- swelling of your face, lips, throat, or tongue
If you develop these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Heparin is derived from animal tissue. It should be used with caution in people with a history of allergy to this drug or to pig proteins.
Taking heparin could be fatal (cause death).
Warnings for people with certain health conditions
For people with pig protein sensitivity: Do not take this drug. This drug is made from pork tissue and can cause a life-threatening allergic reaction in people who are sensitive or allergic to other pig proteins.
For people with uncontrolled high blood pressure: You are at an increased risk of bleeding from this drug. Talk to your doctor before using heparin.
For people with bleeding or clotting problems: If you have abnormal bleeding or a condition that puts you at an increased risk of bleeding, using heparin could increase your risk even more. Use heparin with caution.
For people with a history of stomach ulcers or bleeding: If you have active stomach ulcers, you should not use heparin. It could make your ulcers worse and cause dangerous bleeding. If you have a history of stomach ulcers but don’t have active ulcers, using heparin puts you at an increased risk of bleeding.
You should talk to your doctor before using heparin.
For people with kidney disease: If you have severe kidney disease or a history of kidney disease, taking heparin can increase your risk of bleeding. Talk to your doctor before using heparin.
For people with liver disease: If you have severe liver disease or a history of liver disease, taking heparin can increase your risk of bleeding. Talk to your doctor before using heparin.
For people with asthma or sulfite sensitivity: People with asthma are likely to be sensitive to sulfites. Sulfites can cause a life-threatening allergic reaction in some people. Some forms of this drug contain sulfites. Talk to your doctor about using a sulfite-free version of heparin.
Warnings for other groups
For pregnant women: Research in animals has shown negative effects to the fetus when the mother uses heparin. However, there haven’t been enough studies done in humans to be certain how the drug might affect the fetus.
Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should only be used if the potential benefit justifies the potential risk. Ask your doctor if using the preservative-free version of heparin would be better for you than the version that contains benzyl alcohol.
If you become pregnant while taking this drug, call your doctor right away.
For women who are breastfeeding: Heparin is unlikely to pass into breast milk and be absorbed by an infant who is breastfed. Talk to your doctor about the best way to feed your child while you’re taking heparin.
Some forms of heparin contain a preservative called benzyl alcohol. This ingredient can slow down the central nervous system in some infants. It has also caused trouble breathing and changes in the blood chemistry in some infants. These effects can be deadly. If you breastfeed your child, talk to your doctor about preservative-free heparin.
For seniors: If you are older than 60 years, you may be at a higher risk of bleeding.
Heparin also increases your risk of bleeding, so your doctor may start you on a reduced dosage.
For children: This medication has not been studied in children. Dosage recommendations are based on clinical experience.
Newborns and infants should receive preservative-free heparin. The preservative benzyl alcohol has been linked to serious side effects and even death in newborns and infants.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Drug forms and strengths
Generic: Heparin
- Form: injectable solution, preservative-free
- Strengths: 1,000 units/mL, 10,000 units/mL
- Form: injectable solution preserved with benzyl alcohol
- Strengths: 1,000 units/mL, 5,000 units/mL, 10,000 units/mL, 20,000 units/mL
Dosage for deep vein thrombosis and pulmonary embolism
Adult dosage (ages 18–59 years)
- Typical starting dosage: 333 units/kg of body weight injected under your skin.
- Typical maintenance dosage: 250 units/kg of body weight injected under your skin every 12 hours. Change the injection site each time to prevent a blood clot from forming at the injection site.
Child dosage (ages 0–17 years)
Your doctor will determine your child’s dosage based on your child’s condition and medical history.
Senior dosage (ages 60 years and older)
You may be at higher risk of bleeding. Your doctor may start you on a reduced dosage.
Dosage for preventing deep vein thrombosis after surgery
Adult dosage (ages 18–59 years)
- Typical dosage: Your doctor or nurse will give you 5,000 units about 2 hours before your surgery.
- Typical maintenance dosage: 5,000 units injected under your skin every 8–12 hours. You’ll give yourself this dosage for 7 days or until you can start walking.
Child dosage (ages 0–17 years)
Your doctor will determine your child’s dosage based on your child’s condition and medical history.
Senior dosage (ages 60 years and older)
You may be at higher risk of bleeding. Your doctor may start you on a reduced dosage.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Heparin injectable solution is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: You may develop a blood clot, or an existing blood clot could get worse. These blood clots can be fatal (cause death).
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely.
For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body, which could lead to serious bleeding. This can be deadly. Symptoms of an overdose of this drug can include:
- bruising easily
- unexpected bleeding or bleeding that lasts a long time, such as:
- unusual bleeding from your gums
- frequent nosebleeds
- in women: periods that are heavier than normal
- pink or brown urine
- dark, tarry stool (may be a sign of bleeding in the stomach)
- severe bleeding or bleeding that you can’t stop
- coughing up blood or blood clots
- vomit that contains blood or looks like coffee grounds
- headaches
- weakness
- dizziness
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects, such as serious bleeding.
How to tell if the drug is working: You should not develop a blood clot, or the clot you currently have should go away.
Keep these considerations in mind if your doctor prescribes heparin for you.
Self-management
- Your doctor will show you how to give yourself the injection.
- Use this drug only if the solution is clear and the seal is intact. Do not use this drug if the solution is cloudy, discolored, or has particles in it.
Storage
Store heparin at room temperature between 68°F and 77°F (20°F and 25°C).
Refills
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled.
Your doctor will write the number of refills authorized on your prescription.
Travel
When traveling with your medication:
- Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
- Don’t worry about airport x-ray machines. They can’t harm your medication.
- You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
- Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
- You need needles and syringes to take this medication. Check for special rules about traveling with your medication, needles, and syringes.
Clinical monitoring
Your doctor will monitor how well heparin is working for you by doing coagulation or clotting tests. The results of these tests will also help your doctor choose the right dosage of heparin for you.
Your doctor should test you to help make sure you stay safe while you take this drug. These tests check your:
- Kidney function. If your kidneys are not working well, you may have a higher risk of bleeding. Your doctor will monitor your kidneys to make sure this drug is safe for you to take.
- Liver function. If your liver is not working well, you may have a higher risk of bleeding. Your doctor will monitor your liver to make sure this drug is safe for you to take.
- Signs of bleeding. Your doctor may check your platelet and hematocrit levels. They may do a test that checks for blood that may be hidden in your stool. This monitoring helps make sure you don’t bleed too much while you take this drug.
Availability
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Hidden costs
You may need to purchase:
- sterile alcohol wipes
- needles and syringes
- a sharps container (a bin for disposing used needles safely)
There are other drugs available to treat your condition.
Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
💊 Ingredients of Heparin ✅ Use of Heparin Keep for yourself Search for analogues Interaction Description of the active ingredients of the preparation Heparin The scientific information provided is general and cannot be used to make decisions. Update date: 2019.12.04 Marketing authorization holder: SYNTHESIS, PAO ATX code: B01AB01 (Heparin) Active substance: Rec. WHO registered Dosage form
Release form, packaging and composition |
5 thousand IU / ml: 1 ml or 2 ml amp. 5 or 10 pieces, 5 ml vial 5 or 50 pcs. (4363)
INN
Violates the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor X, to some extent reduces platelet aggregation.
Reduces the frequency of recurrent heart attacks and mortality in patients with myocardial infarction. In high doses, it is effective for pulmonary embolism and venous thrombosis, in small doses it is effective for the prevention of venous thromboembolism, incl. after surgical operations.
| D59.3 | Hemolytic uremic syndrome |
| D65 | Disseminated intravascular coagulation [defibrination syndrome] |
| I20.0 | Unstable angina |
| I21 | Acute myocardial infarction |
| I26 | Pulmonary embolism |
| I33.9 | Acute endocarditis, unspecified |
| I34.0 | Mitral (valvular) insufficiency |
| I48 | Atrial fibrillation and flutter |
| I74 | Arterial embolism and thrombosis |
| I80 | Phlebitis and thrombophlebitis |
| I82 | Embolism and thrombosis of other veins |
| N00 | Acute nephritic syndrome (acute glomerulonephritis) |
| N03 | Chronic nephritic syndrome |
N08. 5 | Glomerular lesions in systemic connective tissue diseases |
| Z51.4 | Preparatory procedures for subsequent treatment or examination, not elsewhere classified |
Dosage regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Individual, depending on the dosage form used, indications, clinical situation and age of the patient.
Side effects
On the part of the blood coagulation system: possible bleeding of the gastrointestinal tract and urinary tract, bleeding at the injection site, in areas subjected to pressure, from surgical wounds, as well as hemorrhages in other organs, hematuria, thrombocytopenia.
From the digestive system: nausea, loss of appetite, vomiting, diarrhea, increased activity of liver transaminases.
Allergic reactions: flushing of the skin, drug fever, urticaria, rhinitis, pruritus and sensation of heat in the soles, bronchospasm, collapse, anaphylactic shock.
On the part of the blood coagulation system: thrombocytopenia (may be severe up to death) with subsequent development of skin necrosis, arterial thrombosis, accompanied by the development of gangrene, myocardial infarction, stroke.
From the musculoskeletal system: with prolonged use – osteoporosis, spontaneous fractures, soft tissue calcification.
Local reactions: irritation, pain, hyperemia, hematoma and ulceration at the injection site.
Other: transient alopecia, hypoaldosteronism.
Contraindications for use
Bleeding, diseases accompanied by impaired blood coagulation, suspected intracranial hemorrhage, cerebral aneurysm, hemorrhagic stroke, dissecting aortic aneurysm, antiphospholipid syndrome, malignant arterial hypertension, subacute bacterial endocarditis, erosive ulcerative lesions of the gastrointestinal tract , severe lesions of the liver parenchyma, cirrhosis of the liver with varicose veins of the esophagus, malignant neoplasms in the liver, shock conditions, recent surgical interventions on the eyes, brain, prostate, liver and biliary tract, condition after spinal cord puncture, menstruation, threatened miscarriage, childbirth (including recent), hypersensitivity to heparin.
Use during pregnancy and lactation
Use during pregnancy is possible only under strict indications, under close medical supervision.
Contraindication: threatened miscarriage, childbirth (including recent).
Can be used during breastfeeding if indicated.
Use in violations of liver function
Contraindications: severe lesions of the liver parenchyma, cirrhosis of the liver with varicose veins of the esophagus, malignant neoplasms in the liver.
Use for impaired renal function
Used when indicated in patients with severe kidney disease.
Use in children
May be used in children if indicated.
Use in elderly patients
Use with caution in elderly patients (over 60 years, especially in women).
Special instructions
Use with caution in patients suffering from polyvalent allergies (including bronchial asthma), arterial hypertension, dental procedures, diabetes mellitus, endocarditis, pericarditis, in the presence of an intrauterine contraceptive, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years, especially women).
IM administration of heparin is not recommended due to the possibility of developing a hematoma, as well as IM administration of other drugs during treatment with heparin.
Use with caution externally for bleeding and conditions of increased bleeding, thrombocytopenia.
During treatment with heparin, monitoring of blood coagulation parameters is necessary.
Only normal saline is used to dilute heparin.
With the development of severe thrombocytopenia (a decrease in the number of platelets by 2 times from the original number or below 100,000 / µl), heparin should be urgently discontinued.
The risk of bleeding can be minimized with careful evaluation of contraindications, regular laboratory monitoring of blood clotting, and adequate dosing.
Drug interactions
The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and NSAIDs.
Ergot alkaloids, thyroxine, tetracycline, antihistamines, and nicotine reduce the effect of heparin.
Keep
If you want to place a link to the description of this drug – use this code
Heparin . Description of the drug in the reference book Vidal.
Everything you need to know about LMW Heparins: mechanism of action and uses
LMW heparins are a class of drugs used to prevent and treat hemostatic disorders. They are highly effective and safe when used in clinical practice. Learn more about the mechanism of action, indications for use and side effects of low molecular weight heparins.
Low molecular weight heparins are a class of anticoagulants that are a variant of heparin, one of the most common drugs used to prevent and treat thrombosis and its complications. However, low molecular weight heparins are distinguished by their unique properties, in particular, their lower molecular weight. This allows them to have more predictable pharmacokinetics and pharmacodynamics, and also reduces the risk of side effects.
The mechanism of action of low molecular weight heparins is based on their ability to bind to and activate a substance called antithrombin III. Activated antithrombin III is able to inactivate clotting factors such as factors Xa and IIa. As a result of this process, fewer thrombin molecules are formed, which leads to a decrease in blood clotting and prevention of blood clots. Due to their mechanism of action, low molecular weight heparins are widely used in the clinic for the prevention and treatment of thrombosis, both in patients in the hospital and on an outpatient basis.
In addition to the prevention and treatment of thrombosis, low molecular weight heparins are also used in other conditions associated with an increased risk of thrombosis, such as myocardial infarction, stroke, angina pectoris and lower extremity edema. In addition, low molecular weight heparins can be prescribed during surgical operations in order to prevent thromboembolic complications.
However, like any drug, low molecular weight heparins have their contraindications and side effects.
Therefore, when prescribing this drug, it is necessary to carefully evaluate the indications and risks of its use for each individual patient. Only by following all the recommendations and prescribing under the supervision of a physician can the best results of therapy with the use of low molecular weight heparins be achieved.
Low molecular weight heparins are small fragments of heparin that exhibit anticoagulant activity. They have a lower molecular weight and shorter chain length than conventional unfractionated heparin.
Inhibition of these clotting factors leads to the suppression of thrombin formation and the prevention of thrombus formation in the circulatory system. Also, low molecular weight heparins can stimulate the release of tissue plasminogen activator, which contributes to the destruction of already formed blood clots.
Low molecular weight heparins (LMWHs) are a heterogeneous group of polysaccharide compounds produced by the chemical or enzymatic degradation of heparin.
They differ from conventional heparin in their lower molecular weight and lower factor II (thrombin) activity. Low molecular weight heparins are often a mixture of different fragments with different molecular weights and chain lengths.
The structure of low molecular weight heparins includes some key components, such as D-glucosaminoglycans and L-iduronic acid, linked together by an ether or ester-ether bond. Also, low molecular weight heparins contain specific domains, including sulfated residues and terminal pre-Xiaodic saccharide structures. All these structural features give low molecular weight heparins unique properties and determine their pharmacological activity.
An important structural element of low molecular weight heparins is their anticoagulant molecules, which block the activity of thrombin and factor Xa. Therefore, they are actively used in clinical practice for the prevention and treatment of thromboembolic complications, such as deep venous thrombosis and pulmonary embolism, as well as for the prevention of thrombosis in surgical interventions and blood clotting disorders.
Q&A:
What are low molecular weight heparins?
Low molecular weight heparins (LMWHs) are a class of anticoagulants that are used to prevent and treat thromboembolic conditions. They are derivatives of native heparin but have a lower molecular weight and better bioavailability. Unlike native heparin, LMWHs have a predictable pharmacokinetic and pharmacodynamic profile, making them safer and more convenient to use.
How do low molecular weight heparins work?
LMWHs work by binding to antithrombin III and increasing its inhibitory effect on clotting factors such as factor IIa and factor Xa. This leads to suppression of the formation of thrombin and a decrease in blood clotting. LMWHs can also act on other coagulation factors and improve the body’s fibrinolytic activity. All this helps to prevent the formation of a blood clot and the development of thromboembolic complications.
Effect of low molecular weight heparins on blood coagulation factors
Low molecular weight heparins are among the most common anticoagulants used in clinical practice.
They exert their action on various blood coagulation factors, which makes them useful tools in the treatment and prevention of thromboembolic complications.
One of the main mechanisms of action of low molecular weight heparins is their ability to bind to antithrombin III, increasing its activity. Antithrombin III is one of the key inhibitors of blood coagulation factors and its activation helps prevent the formation of blood clots.
In addition, low molecular weight heparins are also able to inhibit the activity of factor Xa, which is one of the central links in the blood coagulation pathway. This is achieved by blocking factor Xa and inactivating thrombin, which prevents the formation of blood clots and reduces the risk of thrombosis.
An important feature of low molecular weight heparins is their high predictability and low level of variability in the body’s response to their administration. This makes it possible to accurately dose and control the effectiveness of treatment, which is especially important in an individualized approach to the patient.
Mechanisms of anticoagulant action of low molecular weight heparins
Factor Xa inhibition: Low molecular weight heparins are potent inhibitors of factor Xa, a key factor in thrombin formation. Heparin binds to antithrombin III, which, in turn, is able to inhibit the activity of factor Xa. Thus, low molecular weight heparins further enhance the anticoagulant effect of natural antithrombins III in the body.
Platelet damage: One of the additional mechanisms of anticoagulant action of low molecular weight heparins is their ability to damage platelets. Damaged platelets release substances that break down clots and prevent their formation. This mechanism helps prevent the development of thrombosis and its complications.
Modulation of homeostasis: Low molecular weight heparins also affect the processes of blood coagulation. They are able to modulate the activity of cells responsible for thrombosis and regulate the levels of coagulation factors.
This allows you to maintain homeostasis in the body and prevent excessive blood clots.
Anti-inflammatory effect: In addition to the anticoagulant effect, low molecular weight heparins also have anti-inflammatory properties. They reduce the activity of inflammatory mediators and reduce inflammation in the body. This is especially useful in the treatment of vascular disease, where inflammation and thrombosis are closely related.
As a result, the mechanisms of anticoagulant action of low molecular weight heparins are combined and provide effective prevention and treatment of thrombosis. They help maintain normal hemostasis and prevent the development of serious complications associated with thrombosis.
Use of LMWH
LMWH is widely used in clinical practice due to its anticoagulant action. They are effective drugs for the prevention and treatment of thromboembolic complications such as venous thrombosis and pulmonary embolism. They are also used in surgical practice for the prevention of thrombosis during operations.
Low molecular weight heparins offer a number of advantages over conventional heparins, such as longer duration of action and more predictable pharmacokinetics, allowing for simplified regimens and regimens. They are also well tolerated by patients and have a low risk of side effects such as thrombocytopenia.
Low molecular weight heparins are used alone or in combination with other anticoagulants. They may be used to prevent thrombosis in high-risk patients, such as after hip or knee surgery, in patients with cancer, or who are sedentary.
In addition, low molecular weight heparins can be used in the treatment of acute coronary syndrome and ST-segment elevation myocardial infarction. They help prevent the formation of blood clots in the coronary arteries and improve the prognosis of patients with cardiovascular disease.
Low molecular weight heparins are also used in gynecology, for example for the prevention of thromboembolic complications in pregnant women or in surgery where there is a high risk of thrombosis.
Low molecular weight heparins are presented on the market in various preparations, each of which has its own characteristics and schemes of application. Before starting the use of low molecular weight heparins, it is necessary to consult a doctor who will select the optimal drug and dosage, taking into account the individual characteristics of the patient and the purpose of treatment.
Prevention and treatment of thromboembolic complications
Low molecular weight heparins are widely used for the prevention and treatment of thromboembolic complications. They are an effective means of preventing the formation of blood clots and preventing their consequences.
Prevention of thromboembolic complications is especially important in patients who are in the hospital and are at high risk of developing thrombosis. Low molecular weight heparins can be used alone or in combination with other anticoagulants, depending on the specific situation and indications.
Treatment of thromboembolic complications is carried out using low molecular weight heparins to resolve already formed clots and prevent their recurrence.
Different doses and regimens of heparins can be used depending on the severity and location of the thromboembolic process.
An important feature of low molecular weight heparins is their good tolerability and ease of use. They have a low risk of complications and allow the prevention and treatment of thromboembolic complications without the need for constant monitoring of blood clotting.
Use of low molecular weight heparins in surgery
Low molecular weight heparins are widely used in surgery to prevent thromboembolic complications in patients undergoing surgery. The mechanism of action of low molecular weight heparins is based on the suppression of the activation of factor Xa in prothrombinase.
Low molecular weight heparins have been successfully used in a variety of procedures ranging from small endoscopic procedures to large abdominal procedures. They help reduce the risk of thrombosis and embolism, which are among the most dangerous complications after an operative procedure.
Patients undergoing surgery, especially on the lower extremities or pelvic organs, have an increased risk of blood clots. The intake of low molecular weight heparins in the early postoperative period helps to reduce the risk of thromboembolic complications, such as venous thromboembolism or pulmonary embolism.
The selection of the dose of low molecular weight heparin depends on a number of factors, including the weight of the patient, the nature of the operation, and the presence of risk factors for thrombosis. The period of application of low molecular weight heparin can vary from several days to several weeks, depending on the surgical procedure and the individual characteristics of the patient.
LMW heparins in cardiology
LMW heparins are widely used in cardiology for the prevention and treatment of thrombosis in patients with cardiovascular disease. These drugs have high bioavailability, which allows to achieve stable therapeutic effects.
The mechanism of action of low molecular weight heparins is related to their ability to inhibit blood clotting factors such as thrombin and factor Xa.
This helps prevent blood clots and reduces the risk of serious complications such as myocardial infarction or thrombosis.
Low molecular weight heparins are effective in the treatment of acute conditions such as myocardial infarction or unstable angina. They are also widely used to prevent thromboembolic complications after heart surgery or during prolonged femoral immobilization.
The dosage of low molecular weight heparins in cardiology depends on the severity of the disease and the individual characteristics of the patient. Usually drugs are administered subcutaneously once a day or 2 times a day. The duration of treatment is determined by the doctor depending on the clinical situation and blood coagulation parameters.
Choice and dosage of low molecular weight heparins
Choice and dosage of low molecular weight heparins depends on various factors, including the patient’s weight, age, health status, and the purpose of the drug. It is important to carefully evaluate each patient to determine the optimal dose of low molecular weight heparin.
The low molecular weight heparin enoxaparin is often used to prevent deep vein thrombosis. The standard adult dose is 40 mg subcutaneously once daily. However, for patients at high risk of thrombosis, such as patients with cancer, an increased dose of low molecular weight heparin may be required.
The low molecular weight heparin nadroparin is often used to treat thrombosis. The dosage of nadroparin is also determined individually, depending on the weight of the patient and the severity of thrombosis. The usual starting dose is 85 Units per kg of body weight subcutaneously twice a day, with subsequent dose adjustments according to the results of blood coagulation monitoring.
When using low molecular weight heparins, it is important to regularly monitor blood coagulation to avoid the risk of bleeding or thrombosis. You should also consider possible contraindications and carefully use low molecular weight heparins in patients with impaired renal or hepatic function, as well as in the presence of other concomitant diseases.
Pharmacokinetics and pharmacodynamics of low molecular weight heparins
Pharmacokinetics: Low molecular weight heparins (LMWH) have better bioavailability and a more predictable pharmacokinetic profile compared to unfractionated heparins. After subcutaneous administration, they are rapidly absorbed and reach peak blood concentrations after a few hours. LMWH binds well to plasma proteins and can cross the vascular endothelium.
Pharmacodynamics: LMWH have antithrombotic properties due to interaction with factor Xa, factor Xa inhibitor and tissue factor plasminogen, which leads to inactivation of factor Xa and inhibition of thrombin formation. LMWHs also enhance the action of antithrombin III and prevent the formation of thrombotic clots. Due to their pharmacodynamic properties, LMWHs are effectively used in the prevention and treatment of thromboembolic complications.
Comparison with unfractionated heparins: Unlike LMWH, unfractionated heparins have a more variable pharmacokinetic profile.
They have a higher molecular weight and do not have a uniform chain length, resulting in inhomogeneous activity. Unfractionated heparins require more frequent monitoring of anticoagulation levels and dosing. They can also cause the development of heparin-induced thrombocytopenia. In turn, LMWHs have a lower incidence of such complications and do not require regular monitoring.
Factors affecting the choice of dose of low molecular weight heparins
The choice of dose of low molecular weight heparins depends on several factors that must be considered when prescribing treatment for a patient.
- Patient weight: The dose of low molecular weight heparins is proportional to the patient’s body weight. It is generally recommended to start at a low dose and adjust the dose according to weight.
- Sexual hormonal status: In women with hormonal disorders such as pregnancy or use of oral contraceptives, an increase in the dose of low molecular weight heparins may be required due to an increased risk of thromboembolic complications.
- Degree of functional activity of the liver: In patients with liver failure or reduced functional activity of the liver, it is necessary to reduce the dose of low molecular weight heparins to prevent accumulation of the drug and the development of bleeding.
- Degree of functional activity of the kidneys: Patients with impaired renal function may require a reduction in the dose of low molecular weight heparins due to an increased risk of bleeding.
- Age of the patient: In the elderly, dose adjustment of low molecular weight heparins may be required, since age can affect the metabolism of the drug and the risk of thromboembolic complications.
Before prescribing a dose of low molecular weight heparins, it is necessary to evaluate the above factors and the individual characteristics of the patient in order to select the most appropriate dosage and achieve the optimal treatment effect.
Monitoring of the anticoagulant effect of low molecular weight heparins
To ensure the safety and efficacy of low molecular weight heparin therapy, it is necessary to monitor and control their anticoagulant effect.
This allows you to detect and prevent the development of bleeding or insufficient anticoagulant effect.
Laboratory methods such as activated partial thromboplastin time (APTT) or anti-Xa factor Xa are used to monitor the level of anticoagulant effect of small molecular weight heparins. APTT is a widely used test and correlates well with the activity of low molecular weight heparins, but its main disadvantage is interlaboratory variability and dependence on the reagents used in each laboratory.
Measurement of anti-Xa factor Xa activity using specific drugs and calibrators allows more accurate determination of the concentration of low molecular weight heparins in plasma. This method is more sensitive and specific for measuring the anticoagulant effect of low molecular weight heparins. However, it requires special equipment and highly qualified personnel.
It should be noted that monitoring of the anticoagulant effect of low molecular weight heparins is recommended only in cases where there is a high risk of thrombosis or bleeding, or when the standard dosage is insufficiently effective.
In other cases, such as the prevention of thromboembolic complications, monitoring is not required and the dosage of low molecular weight heparin is carried out according to the manufacturer’s recommendations and the clinical protocol.
Side effects of low molecular weight heparins
Despite their effectiveness and widespread use, low molecular weight heparins can cause a number of side effects that must be considered when using them. First, common side effects include bleeding and uncontrolled bleeding syndromes. This is due to the fact that low molecular weight heparins have an anticoagulant effect, that is, they prevent blood clotting.
In addition, low molecular weight heparins may cause allergic reactions such as skin rash, itching or swelling. These side effects can be mild or severe, and if they occur, you should immediately consult your doctor.
It should also be noted that low molecular weight heparins can cause a decrease in the number of platelets in the blood in patients, which can lead to the development of thrombocytopenia.