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High blood pressure calcium. Calcium Supplementation and Blood Pressure: A Comprehensive Analysis

by alexxlab

How does calcium intake affect blood pressure in normotensive individuals. What are the implications of calcium supplementation for hypertension prevention. Can increased calcium consumption lead to significant health benefits.

The Relationship Between Calcium Intake and Blood Pressure

Hypertension, or high blood pressure, is a major public health concern that significantly increases the risk of cardiovascular and kidney diseases. Recent studies have shown an inverse association between calcium intake and blood pressure, suggesting that increased calcium consumption may have potential benefits for cardiovascular health.

A comprehensive review of 20 randomized controlled trials, involving 3,512 participants, aimed to assess the efficacy and safety of calcium supplementation in normotensive individuals. The primary focus was on evaluating the potential of calcium supplementation as a preventive measure against hypertension.

Effects of Calcium Supplementation on Systolic and Diastolic Blood Pressure

The meta-analysis of 18 studies, encompassing 3,140 participants, revealed significant reductions in both systolic and diastolic blood pressure with calcium supplementation:

  • Systolic blood pressure: Mean difference of -1.37 mmHg (95% CI: -2.08 to -0.66)
  • Diastolic blood pressure: Mean difference of -1.45 mmHg (95% CI: -2.23 to -0.67)

These findings were supported by high-certainty evidence, indicating a consistent and reliable effect of calcium supplementation on blood pressure reduction.

Age-Specific Effects of Calcium Supplementation

The review revealed interesting age-related differences in the effects of calcium supplementation on blood pressure:

Individuals Younger Than 35 Years

  • Systolic blood pressure: Mean difference of -1.86 mmHg (95% CI: -3.45 to -0.27)
  • Diastolic blood pressure: Mean difference of -2.50 mmHg (95% CI: -4.22 to -0.79)

Individuals 35 Years or Older

  • Systolic blood pressure: Mean difference of -0.97 mmHg (95% CI: -1.83 to -0.10)
  • Diastolic blood pressure: Mean difference of -0.59 mmHg (95% CI: -1.13 to -0.06)

These results suggest that younger individuals may experience more pronounced benefits from calcium supplementation in terms of blood pressure reduction.

Gender-Specific Effects of Calcium Supplementation

The analysis also explored potential gender differences in the effects of calcium supplementation on blood pressure:

Women

  • Systolic blood pressure: Mean difference of -1.25 mmHg (95% CI: -2.53 to 0.03)
  • Diastolic blood pressure: Mean difference of -1.04 mmHg (95% CI: -1.86 to -0.22)

Men

  • Systolic blood pressure: Mean difference of -2.14 mmHg (95% CI: -3.71 to -0.59)
  • Diastolic blood pressure: Mean difference of -1.99 mmHg (95% CI: -3.25 to -0.74)

Interestingly, the effect was consistent in both genders regardless of baseline calcium intake, suggesting that calcium supplementation may benefit individuals across different dietary backgrounds.

Implications for Cardiovascular Health

While the observed reductions in blood pressure may seem modest, they could have significant implications for cardiovascular health. Research suggests that even small reductions in blood pressure can lead to substantial health benefits:

  • A 2 mmHg reduction in systolic blood pressure is associated with approximately 10% lower stroke mortality
  • The same reduction is linked to about 7% lower mortality from ischemic heart disease

These findings underscore the potential importance of calcium supplementation as a preventive measure against cardiovascular diseases, particularly in normotensive individuals.

Optimal Dosage and Supplementation Strategies

The review also examined the effects of different calcium dosages on blood pressure. For systolic blood pressure, the results were as follows:

  • Doses less than 1000 mg: Mean difference of -0.02 mmHg (95% CI: -2.23 to 2.20)
  • Doses of 1000 mg or more: Mean difference of -1.05 mmHg (95% CI: -1.89 to -0.22)

These findings suggest that higher doses of calcium supplementation may be more effective in reducing blood pressure. However, further research is needed to determine the optimal dosage and supplementation strategy for maximum benefit.

Future Research Directions

While the current evidence supports the potential benefits of calcium supplementation for blood pressure reduction, several areas require further investigation:

  1. Long-term effects of calcium supplementation on hypertension prevention
  2. Optimal dosage and duration of supplementation for different age groups and populations
  3. Potential side effects and safety concerns associated with long-term calcium supplementation
  4. Interaction between calcium supplementation and other dietary factors affecting blood pressure
  5. Cost-effectiveness of calcium supplementation as a preventive measure against hypertension

Additionally, there is a need for adequately-powered clinical trials focusing on young people, as this group showed the most promising results in terms of blood pressure reduction.

Calcium Supplementation: A Potential Tool for Hypertension Prevention

The comprehensive review of available evidence suggests that calcium supplementation may be a valuable tool in the prevention of hypertension, particularly in young and normotensive individuals. By slightly reducing both systolic and diastolic blood pressure, increased calcium intake could play a role in mitigating the risk of cardiovascular diseases.

Is calcium supplementation suitable for everyone? While the overall effects appear beneficial, individual responses may vary. Factors such as age, gender, baseline calcium intake, and existing health conditions should be considered when determining the appropriateness of calcium supplementation for blood pressure management.

Are there any potential risks associated with calcium supplementation? As with any dietary intervention, it’s essential to consider potential side effects and interactions with other medications or health conditions. Some studies have suggested a possible link between high calcium intake and an increased risk of kidney stones in susceptible individuals. Therefore, it’s crucial to consult with a healthcare professional before starting any supplementation regimen.

Integrating Calcium Supplementation into a Healthy Lifestyle

While calcium supplementation shows promise in blood pressure management, it should not be viewed as a standalone solution. Rather, it should be integrated into a comprehensive approach to cardiovascular health that includes:

  • A balanced diet rich in fruits, vegetables, and whole grains
  • Regular physical activity
  • Stress management techniques
  • Limiting alcohol consumption and avoiding tobacco use
  • Maintaining a healthy body weight

By combining calcium supplementation with these lifestyle factors, individuals may maximize their potential for maintaining healthy blood pressure levels and reducing their risk of cardiovascular diseases.

Calcium-Rich Foods vs. Supplements

Is it better to obtain calcium from dietary sources or supplements? While the studies reviewed primarily focused on calcium supplementation, it’s worth noting that dietary calcium may offer additional benefits. Calcium-rich foods often contain other nutrients that support cardiovascular health, such as potassium, magnesium, and vitamin D.

Some excellent dietary sources of calcium include:

  • Dairy products (milk, yogurt, cheese)
  • Leafy green vegetables (kale, spinach, collard greens)
  • Fish with edible bones (sardines, canned salmon)
  • Calcium-fortified foods (orange juice, cereals, plant-based milk alternatives)

Incorporating these foods into one’s diet may provide a natural and balanced approach to increasing calcium intake. However, for individuals who struggle to meet their calcium needs through diet alone, supplements may be a viable option under the guidance of a healthcare professional.

The Role of Vitamin D in Calcium Absorption

Can vitamin D supplementation enhance the blood pressure-lowering effects of calcium? Vitamin D plays a crucial role in calcium absorption and utilization in the body. Some studies suggest that combining calcium and vitamin D supplementation may have synergistic effects on blood pressure regulation.

Factors that may influence vitamin D status include:

  • Sun exposure
  • Skin pigmentation
  • Age
  • Geographical location
  • Dietary intake of vitamin D-rich foods

Future research should explore the potential benefits of combined calcium and vitamin D supplementation for blood pressure management and overall cardiovascular health.

Calcium Supplementation in Special Populations

How might the effects of calcium supplementation differ in specific populations? While the reviewed studies focused primarily on normotensive individuals, it’s important to consider the potential impact of calcium supplementation in other groups:

  • Pregnant women: Calcium supplementation during pregnancy has been associated with reduced risk of preeclampsia and gestational hypertension
  • Elderly individuals: Calcium supplementation may have dual benefits of supporting bone health and potentially lowering blood pressure
  • Individuals with lactose intolerance or dairy allergies: These groups may benefit from non-dairy calcium sources or supplements to meet their calcium needs
  • People with a history of kidney stones: Careful monitoring may be necessary when considering calcium supplementation in this population

Further research is needed to elucidate the specific effects and optimal supplementation strategies for these diverse groups.

Economic Implications of Calcium Supplementation

Could widespread calcium supplementation lead to significant healthcare cost savings? Given the potential reduction in cardiovascular disease risk associated with even small decreases in blood pressure, the economic implications of calcium supplementation as a preventive measure are worth considering.

Factors to consider in a cost-benefit analysis include:

  • Cost of calcium supplements
  • Potential reduction in healthcare expenditures related to hypertension and cardiovascular diseases
  • Quality of life improvements associated with better cardiovascular health
  • Comparison with other preventive strategies and interventions

Future economic studies could provide valuable insights into the potential cost-effectiveness of calcium supplementation as a public health strategy for hypertension prevention.

Mechanisms Linking Calcium Intake and Blood Pressure Regulation

What are the underlying physiological mechanisms by which calcium affects blood pressure? Several potential pathways have been proposed:

  1. Calcium’s role in vascular smooth muscle contraction and relaxation
  2. Influence on the renin-angiotensin-aldosterone system
  3. Effects on sodium and water balance
  4. Modulation of sympathetic nervous system activity
  5. Potential interactions with other electrolytes, such as potassium and magnesium

Understanding these mechanisms more thoroughly could lead to improved strategies for leveraging calcium’s blood pressure-lowering effects and potentially identifying synergistic interventions.

Long-Term Effects and Safety Considerations

Are there any long-term risks associated with calcium supplementation for blood pressure management? While the short-term effects appear promising, it’s crucial to investigate the long-term safety and efficacy of calcium supplementation:

  • Potential impact on bone health and osteoporosis risk
  • Effects on cardiovascular calcification
  • Interactions with other minerals and nutrients
  • Optimal duration of supplementation for sustained benefits

Long-term follow-up studies and comprehensive safety assessments will be essential to fully understand the risk-benefit profile of calcium supplementation for blood pressure management.

Personalized Approaches to Calcium Supplementation

Can genetic factors influence an individual’s response to calcium supplementation? As personalized medicine continues to advance, it’s worth exploring whether genetic variations may affect the blood pressure response to calcium intake:

  • Polymorphisms in calcium-sensing receptors
  • Genetic variations affecting calcium absorption and metabolism
  • Interactions between calcium intake and genes involved in blood pressure regulation

Future research in nutrigenomics could potentially lead to more targeted and effective calcium supplementation strategies based on individual genetic profiles.

Calcium Supplementation in the Context of Overall Dietary Patterns

How does the effect of calcium supplementation interact with other dietary factors? It’s important to consider calcium intake within the broader context of overall dietary patterns:

  • Potential synergistic effects with other minerals (e.g., potassium, magnesium)
  • Interactions with dietary approaches such as the DASH (Dietary Approaches to Stop Hypertension) diet
  • Impact of overall nutrient balance on calcium’s blood pressure-lowering effects

Future studies should aim to elucidate the complex interplay between calcium supplementation and other dietary components in blood pressure regulation.

Public Health Implications and Policy Considerations

Should calcium supplementation be considered as part of public health strategies for hypertension prevention? Given the potential benefits observed in the reviewed studies, policymakers and public health officials may need to consider the role of calcium supplementation in broader cardiovascular health initiatives:

  • Development of dietary guidelines that emphasize adequate calcium intake
  • Potential fortification of staple foods with calcium in populations at risk of deficiency
  • Education programs to raise awareness about the importance of calcium for cardiovascular health
  • Integration of calcium supplementation recommendations into existing hypertension prevention strategies

Careful consideration of the evidence, cost-effectiveness, and potential population-wide impacts will be crucial in formulating sound public health policies related to calcium intake and blood pressure management.

Conclusion

The comprehensive review of available evidence suggests that calcium supplementation may offer a promising approach to blood pressure management and hypertension prevention, particularly in young and normotensive individuals. The observed reductions in both systolic and diastolic blood pressure, while modest, could translate into significant cardiovascular health benefits at the population level.

However, it’s important to note that calcium supplementation should not be viewed as a standalone solution but rather as part of a holistic approach to cardiovascular health. Integrating increased calcium intake with other lifestyle modifications, such as a balanced diet, regular physical activity, and stress management, may provide the most comprehensive strategy for maintaining healthy blood pressure levels.

As research in this area continues to evolve, future studies should focus on addressing key questions such as optimal dosage, long-term safety, and potential interactions with other nutrients and medications. Additionally, exploring the effects of calcium supplementation in diverse populations and investigating the underlying mechanisms of action will be crucial in refining our understanding of calcium’s role in blood pressure regulation.

Ultimately, the potential of calcium supplementation as a tool for hypertension prevention highlights the importance of nutrition in maintaining cardiovascular health. As we continue to unravel the complex relationships between dietary factors and blood pressure, we may uncover new strategies to combat the global burden of hypertension and its associated complications.

Extra calcium to prevent high blood pressure

Authors’ conclusions: 

An increase in calcium intake slightly reduces both systolic and diastolic blood pressure in normotensive people, particularly in young people, suggesting a role in the prevention of hypertension. The effect across multiple prespecified subgroups and a possible dose response effect reinforce this conclusion. Even small reductions in blood pressure could have important health implications for reducing vascular disease. A 2 mmHg lower systolic blood pressure is predicted to produce about 10% lower stroke mortality and about 7% lower mortality from ischaemic heart disease.

There is a great need for adequately-powered clinical trials randomising young people. Subgroup analysis should involve basal calcium intake, age, sex, basal blood pressure, and body mass index. We also require assessment of side effects, optimal doses and the best strategy to improve calcium intake.

Read the full abstract. ..

Background: 

Hypertension is a major public health problem that increases the risk of cardiovascular and kidney diseases. Several studies have shown an inverse association between calcium intake and blood pressure, as small reductions in blood pressure have been shown to produce rapid reductions in vascular disease risk even in individuals with normal blood pressure ranges. This is the first update of the review to evaluate the effect of calcium supplementation in normotensive individuals as a preventive health measure.

Objectives: 

To assess the efficacy and safety of calcium supplementation versus placebo or control for reducing blood pressure in normotensive people and for the prevention of primary hypertension.

Search strategy: 

The Cochrane Hypertension Information Specialist searched the following databases for randomised controlled trials up to September 2020: the Cochrane Hypertension Specialised Register, CENTRAL (2020, Issue 9), Ovid MEDLINE, Ovid Embase, the WHO International Clinical Trials Registry Platform, and the US National Institutes of Health Ongoing Trials Register, ClinicalTrials. gov. We also contacted authors of relevant papers regarding further published and unpublished work. The searches had no language restrictions.

Selection criteria: 

We selected trials that randomised normotensive people to dietary calcium interventions such as supplementation or food fortification versus placebo or control. We excluded quasi-random designs. The primary outcomes were hypertension (defined as blood pressure ≥ 140/90 mmHg) and blood pressure measures.

Data collection and analysis: 

Two review authors independently selected trials for inclusion, abstracted the data and assessed the risks of bias. We used the GRADE approach to assess the certainty of evidence.

Main results: 

The 2020 updated search identified four new trials. We included a total of 20 trials with 3512 participants, however we only included 18 for the meta-analysis with 3140 participants. None of the studies reported hypertension as a dichotomous outcome. The effect on systolic and diastolic blood pressure was: mean difference (MD) -1. 37 mmHg, 95% confidence interval (CI) -2.08, -0.66; 3140 participants; 18 studies; I2 = 0%, high-certainty evidence; and MD -1.45, 95% CI -2.23, -0.67; 3039 participants; 17 studies; I2 = 45%, high-certainty evidence, respectively. The effect on systolic and diastolic blood pressure for those younger than 35 years was: MD -1.86, 95% CI -3.45, -0.27; 452 participants; eight studies; I2 = 19%, moderate-certainty evidence; MD -2.50, 95% CI -4.22, -0.79; 351 participants; seven studies ; I2 = 54%, moderate-certainty evidence, respectively. The effect on systolic and diastolic blood pressure for those 35 years or older was: MD -0.97, 95% CI -1.83, -0.10; 2688 participants; 10 studies; I2 = 0%, high-certainty evidence; MD -0.59, 95% CI -1.13, -0.06; 2688 participants; 10 studies; I2 = 0%, high-certainty evidence, respectively. The effect on systolic and diastolic blood pressure for women was: MD -1.25, 95% CI -2.53, 0.03; 1915 participants; eight studies; I2 = 0%, high-certainty evidence; MD -1. 04, 95% CI -1.86, -0.22; 1915 participants; eight studies; I2 = 4%, high-certainty evidence, respectively. The effect on systolic and diastolic blood pressure for men was MD -2.14, 95% CI -3.71, -0.59; 507 participants; five studies; I2 = 8%, moderate-certainty evidence; MD -1.99, 95% CI -3.25, -0.74; 507 participants; five studies; I2 = 41%, moderate-certainty evidence, respectively. The effect was consistent in both genders regardless of baseline calcium intake.

The effect on systolic blood pressure was: MD -0.02, 95% CI -2.23, 2.20; 302 participants; 3 studies; I2 = 0%, moderate-certainty evidence with doses less than 1000 mg; MD -1.05, 95% CI -1.91, -0.19; 2488 participants; 9 studies; I2 = 0%, high-certainty evidence with doses 1000 to 1500 mg; and MD -2.79, 95% CI -4.71, 0.86; 350 participants; 7 studies; I2 = 0%, moderate-certainty evidence with doses more than 1500 mg. The effect on diastolic blood pressure was: MD -0. 41, 95% CI -2.07, 1.25; 201 participants; 2 studies; I2 = 0, moderate-certainty evidence; MD -2.03, 95% CI -3.44, -0.62 ; 1017 participants; 8 studies; and MD -1.35, 95% CI -2.75, -0.05; 1821 participants; 8 studies; I2 = 51%, high-certainty evidence, respectively.

None of the studies reported adverse events.

Daily calcium intake and its relation to blood pressure, blood lipids, and oxidative stress biomarkers in hypertensive and normotensive subjects

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Calcium supplement for prevention of high blood pressure

Review question

We wanted to find out how calcium intake affects blood pressure in people with normal blood pressure.

Relevance

Hypertension is a serious medical problem that increases the risk of heart and kidney disease. Several studies have shown that increasing calcium intake lowers blood pressure, even in people with normal blood pressure. Increasing calcium intake also has a beneficial effect on pregnancy outcomes – the effects of which are also believed to be mediated by lowering blood pressure. High blood pressure has been identified as a major risk factor for mortality, and even a small reduction in blood pressure can reduce the incidence of coronary artery disease, stroke, and death.

Study profile

We selected studies that evaluated the effect of calcium-supplemented dietary interventions, such as supplements or food fortification, on blood pressure in people of all ages with normal blood pressure. The last search was conducted in September 2020.

Main results

This review analyzed information from 20 trials, of which 18 trials (3140 participants) provided data on the effect(s) of the intervention. We found that increasing calcium intake slightly reduced both systolic and diastolic blood pressure by 1.37 mmHg. Art. and 1.45 mm Hg. Art. respectively. This effect was greater at calcium doses greater than 1000 mg/day. Systolic blood pressure decreased by 1.05 mm Hg. Art. at calcium dosages of 1000 to 1500 mg/day and 2.79mmHg Art. at doses equal to or greater than 1500 mg/day.

We noted a decrease in blood pressure in men and women aged 11 to 82, but the decrease was more pronounced among younger people. Systolic blood pressure decreased by 1.86 mm Hg. Art. among people under 35 and 0.97 mm Hg. Art. among people aged 35 years or older.

No studies reported adverse events. We need further research to determine the ideal dosage and whether it is more effective and safer as part of a diet or as a supplement.

Quality of evidence

We found high-quality evidence for systolic and diastolic blood pressure in men and women. The quality of the evidence was also high for participants aged 35 years or older and moderate for younger participants.

The quality of the evidence was high for calcium doses of 1000 to 1500 mg/day and moderate for lower or higher doses.

Five of the 18 trials were funded by manufacturers.

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Translation notes:

Translation: Vanzhula Victoria Alexandrovna. Editing: Yudina Ekaterina Viktorovna. Project coordination for translation into Russian: Cochrane Russia – Cochrane Russia on the basis of the Russian Medical Academy of Continuing Professional Education (RMANPE). For questions related to this translation, please contact us at: [email protected]

FROM EVERY DISEASE – A OWN MEDICINE

As new drugs were developed, the effectiveness of the treatment of hypertension increased.

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10-15 percent
cases of hypertension
associated with increased action
adrenaline hormone in the heart.
Heart beats faster
throws out more blood, and
pressure rises above normal.
This disease is especially common
occurs at a young age. For
medications are used,
impeding action
adrenaline in the heart: inderal,
obzidan, whisken
(pindodol), corguard (nadalol),
cordanum (talinolol). Help and
substances that reduce arousal
nerves responsible for tone
vessels: clonidine (hemiton,
catapresan), guanfacine (estulik).

Increased
the sodium content in the blood
increases pressure because
heart in one contraction
throws out more blood than
usually. With this form
help hypertension
diuretics that remove
excess water from the body and
affecting the exchange of salts, especially
potassium. This triampur and furosemide,
which is used to eliminate
hypertensive crises. To
make up for the lack of potassium in
body, prescribe veroshpiron
(aldactone). reserpine, apressin and
other means of expanding
small blood vessels
cause swelling, just like Adelfan,
which in this form of the disease
Not recommended. Unfortunately, to
all diuretic develops
addictive and they no longer render
the desired action.

Increase
intracellular calcium content
leads to a calcium-dependent form
hypertension. At the same time,
the patient has spasms
smooth muscle, including
the muscles that support
vessel walls. Regulation
blood pressure is disturbed.
To improve calcium metabolism
taking calcium gluconate
accumulating in the blood, it interferes
penetration of calcium into cells.
Can also be used crushed
eggshell powder. At the same time
reduced bone fragility
older people often suffer
especially women on the offensive
menopause. But much more
drugs are effective
preventing the entry of calcium into
cells: nifedipine (Corinfar),
nitrendipine (bypress), verapamil
(isoptin).

Some
due to lack of oxygen
angiotensin-I protein in tissues
contained in the blood of healthy
people, turns into matter
angiotensin II, which has
ability to constrict blood vessels.