How does drysol work. Drysol for Hyperhidrosis: Mechanism, Efficacy, and Alternatives

16.04.202111.07.2023 by alexxlab

How does Drysol work to treat excessive sweating. What are the potential side effects of using Drysol. What alternative treatments are available for hyperhidrosis.

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Understanding Hyperhidrosis: Causes and Types

Hyperhidrosis is a medical condition characterized by excessive sweating beyond what is necessary for normal thermoregulation. This condition affects approximately 5% of Americans, which translates to about 15.3 million people. However, this number may be an underestimate as many individuals do not report their symptoms to healthcare providers.

There are two main types of hyperhidrosis:

Primary focal hyperhidrosis
Secondary generalized hyperhidrosis

Primary Focal Hyperhidrosis

Primary focal hyperhidrosis is a condition where excessive sweating is the primary medical issue, not caused by medications or other underlying conditions. It typically affects specific areas of the body, such as:

Hands
Feet
Underarms
Face/head

Characteristics of primary focal hyperhidrosis include:

Symmetrical sweating (affects both sides of the body equally)
Onset during childhood or teenage years
Sweating episodes occur at least once a week
Rare occurrence during sleep
Possible genetic component (family history of excessive sweating)

Secondary Generalized Hyperhidrosis

Secondary generalized hyperhidrosis is excessive sweating caused by an underlying medical condition or medication side effects. Some key features include:

Affects larger areas of the body
Often starts in adulthood
Can occur during sleep (night sweats)
May be caused by conditions such as hyperthyroidism or menopause

Drysol: A Prescription Solution for Excessive Sweating

Drysol is a prescription-strength antiperspirant used to treat hyperhidrosis. Its active ingredient is aluminum chloride hexahydrate, a metallic salt that effectively reduces perspiration.

How does Drysol differ from over-the-counter antiperspirants?

The main difference between Drysol and over-the-counter antiperspirants lies in the concentration of active ingredients:

Drysol can contain up to 20% aluminum chloride hexahydrate
Over-the-counter antiperspirants are limited to a maximum of 15% aluminum chloride hexahydrate

Additionally, over-the-counter products may use other metallic salts, such as aluminum chlorohydrate and aluminum zirconium salts, in varying concentrations.

The Science Behind Drysol’s Effectiveness

Drysol’s mechanism of action involves the interaction between its active ingredient, aluminum chloride hexahydrate, and sweat. Here’s how it works:

Sweat glands produce and pump sweat onto the skin’s surface
The metallic salts in Drysol mix with the sweat
This mixture is pulled into the sweat duct
A chemical reaction occurs, forming a plug that blocks the sweat gland
The blockage reduces perspiration in the treated area

Potential Side Effects of Drysol

While Drysol can be highly effective in managing hyperhidrosis, it may cause some side effects. These are typically limited to the application site and resolve after discontinuation of use.

Common side effects include:

Skin irritation
Stinging sensation
Itching
Burning or prickling sensation
Skin darkening (hyperpigmentation)

Alternative Treatments for Hyperhidrosis

While prescription antiperspirants like Drysol are often the first line of treatment for hyperhidrosis, several alternative options are available:

Over-the-Counter Antiperspirants

These products can be effective for mild cases of hyperhidrosis, though they may not provide sufficient relief for more severe cases. They are readily available and can be a good starting point for managing excessive sweating.

Iontophoresis

This treatment involves immersing the hands or feet in water while a low-voltage electric current is passed through it. The current helps to temporarily shut down sweat glands in the treated area.

Botulinum Toxin Injections

Botox injections can be used to treat hyperhidrosis by blocking the nerves that stimulate sweat glands. This treatment is particularly effective for axillary (underarm) hyperhidrosis.

Oral Medications

Anticholinergic drugs, such as glycopyrrolate or oxybutynin, can be prescribed to reduce sweating. However, these medications may have systemic side effects and should be used under close medical supervision.

Microwave Therapy

This non-invasive treatment uses microwave energy to destroy sweat glands in the underarm area. It’s a relatively new approach that has shown promising results in clinical studies.

Lifestyle Modifications to Complement Hyperhidrosis Treatment

In addition to medical treatments, certain lifestyle changes can help manage hyperhidrosis:

Wearing breathable, moisture-wicking fabrics
Using absorbent shoe insoles
Avoiding triggers such as spicy foods or caffeine
Practicing stress-reduction techniques like meditation or yoga
Using antiperspirant at night for maximum effectiveness

When to Seek Medical Advice for Excessive Sweating

While some degree of sweating is normal and necessary for thermoregulation, excessive sweating can significantly impact quality of life. Consider consulting a healthcare provider if:

Sweating interferes with daily activities
You experience night sweats without an apparent cause
You suddenly start sweating more than usual
You experience sweating accompanied by chest pain, shortness of breath, or fever

A healthcare professional can help diagnose the underlying cause of excessive sweating and recommend appropriate treatment options, which may include Drysol or other interventions.

The Future of Hyperhidrosis Treatment

Research into hyperhidrosis treatment is ongoing, with several promising avenues being explored:

Gene Therapy

Scientists are investigating the genetic factors contributing to hyperhidrosis, which could lead to targeted gene therapies in the future.

Sweat Gland Inhibitors

New topical treatments that directly inhibit sweat gland function without the use of metallic salts are in development.

Advanced Neuromodulation Techniques

Researchers are exploring more precise methods of interrupting the nerve signals that trigger excessive sweating, potentially offering longer-lasting results with fewer side effects.

As our understanding of hyperhidrosis grows, so too does the potential for more effective and personalized treatment options. While Drysol remains a valuable tool in managing excessive sweating, the future may hold even more targeted and efficient solutions for those affected by this condition.

The Psychological Impact of Hyperhidrosis

Excessive sweating can have significant psychological effects on individuals, often leading to:

Social anxiety
Embarrassment
Decreased confidence
Isolation
Depression

Addressing these psychological aspects is crucial in the comprehensive management of hyperhidrosis. Healthcare providers may recommend:

Cognitive-behavioral therapy
Support groups
Stress management techniques

By combining medical treatments like Drysol with psychological support, individuals with hyperhidrosis can experience improved quality of life and better overall well-being.

Navigating Insurance Coverage for Hyperhidrosis Treatments

Insurance coverage for hyperhidrosis treatments, including Drysol, can vary widely. Some key points to consider:

Many insurance plans cover prescription antiperspirants like Drysol
Coverage for more advanced treatments (e.g., Botox injections) may require pre-authorization
Some treatments might be considered cosmetic and not covered by insurance

To navigate insurance coverage:

Check your policy details or contact your insurance provider
Discuss coverage options with your healthcare provider
Consider appealing denials with supporting documentation from your doctor

Understanding your insurance coverage can help you make informed decisions about your hyperhidrosis treatment plan and manage associated costs effectively.

In conclusion, while Drysol offers an effective solution for many individuals struggling with hyperhidrosis, it’s important to consider all available options and work closely with healthcare providers to develop a comprehensive treatment plan. As research continues and new treatments emerge, the future looks promising for those affected by excessive sweating.

What Is Drysol? How Does Treat Excessive Sweating?

What is hyperhidrosis?
What is Drysol?
How does Drysol work?
Potential side effects of Drysol
Alternative hyperhidrosis treatments

If you have any medical questions or concerns, please talk to your healthcare provider. The articles on Health Guide are underpinned by peer-reviewed research and information drawn from medical societies and governmental agencies. However, they are not a substitute for professional medical advice, diagnosis, or treatment.

When your body senses a rise in temperature, it turns on your sweat glands—whether you want it to or not! Several things can lead to sweating, including warm temperatures, exercise, or feelings of anger, embarrassment, nervousness, or fear. Sweating is a necessary and natural response to an increase in body temperature to help you cool off. However, if you sweat excessively, you may have a medical condition known as hyperhidrosis.

People with hyperhidrosis often sweat more than usual, even without the typical triggers. If you think you may have hyperhidrosis, you are not alone—almost 5% of Americans (15.3 million people) have hyperhidrosis (Doolittle, 2016). This number is likely lower than the actual amount of people with hyperhidrosis because many never mention it to their healthcare provider. Most people don’t realize that their excessive sweating is a medical problem.

Hyperhidrosis is divided into two types: primary focal hyperhidrosis and secondary generalized hyperhidrosis.

If the excessive sweating itself is the medical condition, then you have primary hyperhidrosis. In other words, your hyperhidrosis is not caused by any medications you may be taking or by another medical condition. Primary focal hyperhidrosis most commonly affects the hands, feet, underarms, and/or face/head. These areas are usually affected equally on both sides of the body.

Most people with primary hyperhidrosis report that their symptoms began in childhood or during their teenage years. In addition, the sweating episodes usually happen at least once a week, but rarely during sleep. Genetics seems to play a role as most people with primary hyperhidrosis also have a family member with excessive sweating.

Secondary generalized hyperhidrosis, on the other hand, is sweating is caused by another medical condition (like hyperthyroidism or menopause) or medication side effects. People with secondary generalized hyperhidrosis may complain of sweating “all over” as this condition often affects larger areas of the body. Unlike primary focal hyperhidrosis, secondary generalized hyperhidrosis usually starts in adulthood, and sweating can happen while asleep (night sweats).

Drysol is a prescription topical antiperspirant often used to treat hyperhidrosis. The active ingredient in Drysol is the metallic salt, aluminum chloride hexahydrate. Over-the-counter antiperspirants can also contain metallic salts, but the main difference between Drysol and over-the-counter antiperspirants is the type and concentration of metallic salts. The maximum concentration of aluminum chloride hexahydrate allowed by the FDA in over-the-counter antiperspirants is 15%. On the other hand, Drysol can go as high as 20% (FDA, 2019). Other metallic salts, like aluminum chlorohydrate and aluminum zirconium salts, can also be used in over-the-counter antiperspirants in varying concentrations.

Drysol’s effectiveness comes from the aluminum chloride salt, aluminum chloride hexahydrate. When you sweat, your sweat glands pump sweat onto your skin’s surface. After applying Drysol to your skin, the metallic salts mix with your sweat and then get pulled into the sweat duct. Once there, a chemical reaction occurs, and the salt-sweat mixture blocks the sweat gland, reducing perspiration.

Hyperhidrosis

Last updated: Feb 27, 2020

7 min read

Like any medication, there can be side effects with Drysol. Since this is a topical medication, the side effects are usually limited to the sites of application and then resolve after stopping it. Side effects include (Woolery-Lloyd, 2009):

Skin irritation
Stinging at the site of application
Itching at the site of application
Burning or prickling sensation at the site of application
Darkening of the skin (hyperpigmentation)

While prescription antiperspirants like Drysol are some of the first treatments recommended for hyperhidrosis, other options exist, including:

Over-the-counter antiperspirants: These are often less effective than the prescription antiperspirants for people with excessive sweating but are certainly an option to try.
Iontophoresis: Immersing your hands or feet in tap water while a medical device sends a low-voltage electric current through the water to shut down the sweat glands.
Anticholinergic medications: These oral medications prevent acetylcholine (a brain chemical or neurotransmitter) from turning on your sweat glands.
Botulinum toxin (brand name Botox): These are injections that temporarily block acetylcholine release to prevent the stimulation of sweat glands in affected areas.
Surgery: Some people have surgery to remove the sweat glands or cut the sympathetic nerves that stimulate you to sweat in a particular area (sympathectomy).

If you have hyperhidrosis, Drysol may be a treatment option for you. Talk to your healthcare provider about your symptoms and what remedies you have already tried. Hyperhidrosis can be embarrassing for some, but it is treatable

Doolittle, J., Walker, P., Mills, T., & Thurston, J. (2016). Hyperhidrosis: an update on prevalence and severity in the United States. Archives of Dermatological Research, 308(10), 743–749. doi: 10.1007/s00403-016-1697-9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099353/
U.S Food and Drug Administration (FDA) Code of Federal Regulations Title 21. (2019). Retrieved 9 June 2020, from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=350&showFR=1 https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=350&showFR=1
Woolery-Lloyd, H. , & Valins, W. (2009). Aluminum chloride hexahydrate in a salicylic Acid gel: a novel topical agent for hyperhidrosis with decreased irritation. The Journal of clinical and aesthetic dermatology, 2(6), 28–31. https://pubmed.ncbi.nlm.nih.gov/20729946/

Dr. Mike is a licensed physician and the Director, Medical Content & Education at Ro.

Drysol Dab-O-Matic Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

How to use Drysol Solution, Non-

Use this medication on the skin only. The affected area should be dry before the medication is applied. If needed, dry the affected area with a hair dryer on the warm setting for a few minutes. Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist.

Do not get the medication in your eyes or apply it to broken, irritated, or recently shaved skin. If you do get the medication on those areas, flush with plenty of water.

Apply a thin layer of this medication to the affected area, usually once daily at bedtime for 2 to 3 days until the sweating is controlled, then once or twice a week thereafter or as directed by your doctor. After applying the medication, let it dry. If applying on the hands or feet, wrap the area with plastic wrap and cover with a mitten or sock. If applying on the underarms, wear a shirt. If applying on the scalp, wear a plastic shower cap. Leave this medication on for 6 to 8 hours. In the morning, wash the area with soap (or shampoo if treating the scalp) and water, and then towel dry. Do not use other antiperspirants or deodorants while using this medication.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Tingling, mild itching, or irritation may occur when the medication is first applied. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using aluminum chloride, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may stain clothing or certain fabrics or harm metals. Use this medication cautiously to avoid contact with clothes, bed linens, other fabrics, or metals. Let this medication dry completely before putting clothing over the treated area.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: deodorants, other antiperspirants, disulfiram, metronidazole, tinidazole.

Does Drysol Solution, Non- interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from heat. Do not use near an open flame. Keep container tightly closed. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Drysol Dab-O-Matic 20 % topical solution

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This medicine is a solution