What is L-lysine and why is it important for human health. How does L-lysine contribute to proper growth and bodily functions. What are the potential benefits of L-lysine supplementation for various health conditions.

Understanding L-Lysine: The Fundamental Amino Acid

L-lysine, commonly referred to as lysine, is an essential amino acid that plays a crucial role in human health. As an essential amino acid, our bodies cannot produce lysine on their own, making it necessary to obtain it through diet or supplementation. Lysine serves as a fundamental building block for proteins, which are vital for numerous bodily functions and structures.

Why is lysine considered essential? The human body relies on lysine for:

• Proper growth and development
• Production of carnitine, a nutrient that converts fatty acids into energy
• Cholesterol regulation
• Calcium absorption
• Formation of collagen, a key component in bones and connective tissues

The Role of L-Lysine in Bodily Functions

How does lysine contribute to overall health? This amino acid is involved in various physiological processes:

1. Protein synthesis: Lysine is crucial for the production of proteins, which are essential for tissue repair and growth.
2. Enzyme and antibody production: It aids in the formation of enzymes and antibodies, supporting immune function.
3. Hormone synthesis: Lysine plays a role in the production of certain hormones.
4. Calcium absorption: It enhances the body’s ability to absorb and retain calcium, promoting bone health.
5. Collagen formation: Lysine is a key component in the production of collagen, which is vital for skin, tendons, and cartilage.

Lysine Deficiency: Symptoms and Risks

Can a lack of lysine impact health? While lysine deficiency is rare in developed countries, certain groups may be at risk. Symptoms of lysine deficiency may include:

• Fatigue and weakness
• Nausea and dizziness
• Loss of appetite
• Agitation and mood changes
• Bloodshot eyes
• Slow growth in children
• Anemia
• Reproductive disorders

Who is most at risk for lysine deficiency? Athletes engaging in intense physical activities, burn patients with increased protein needs, and vegans who do not consume beans or other lysine-rich plant sources may require additional lysine intake.

Dietary Sources of L-Lysine

Where can one find natural sources of lysine? Lysine is abundant in various protein-rich foods:

• Red meat, pork, and poultry
• Fish, particularly cod and sardines
• Cheese, especially Parmesan
• Eggs
• Soybeans and soy products (tofu, isolated soy protein)
• Spirulina
• Fenugreek seeds
• Brewer’s yeast
• Beans and other legumes
• Dairy products

For vegans and vegetarians, what are the best plant-based sources of lysine? Legumes, including beans, peas, and lentils, are excellent sources of lysine for those following a plant-based diet. Additionally, quinoa, pistachios, and pumpkin seeds provide significant amounts of this essential amino acid.

L-Lysine Supplementation: Forms and Uses

In what forms is lysine available as a supplement? L-lysine supplements come in various forms to suit different preferences and needs:

• Tablets
• Capsules
• Creams
• Liquid formulations

Most supplements are sold in the L-lysine form, which is the biologically active version of the amino acid that our bodies can readily use.

Potential Health Benefits of L-Lysine Supplementation

Can L-lysine supplementation offer health benefits beyond meeting basic nutritional needs? Research suggests several potential applications:

1. Herpes simplex virus (HSV) management: Some studies indicate that regular lysine intake may help prevent outbreaks of cold sores and genital herpes. Lysine’s antiviral effects work by blocking arginine, which promotes HSV replication.
2. Osteoporosis prevention: Lysine’s role in calcium absorption and retention may contribute to maintaining bone density, potentially reducing the risk of osteoporosis.
3. Athletic performance: Some athletes use lysine as a protein supplement to aid in muscle recovery after intense physical activity.
4. Anxiety reduction: Emerging research suggests lysine may have anxiolytic properties, potentially helping to reduce anxiety symptoms.
5. Wound healing: Lysine’s involvement in collagen production may support faster wound healing and tissue repair.

L-Lysine and Herpes Simplex Virus Management

How effective is lysine in managing herpes simplex virus infections? The efficacy of lysine for HSV management has been a subject of scientific inquiry:

• Prevention: Some studies suggest that regular lysine supplementation may help prevent HSV outbreaks.
• Symptom reduction: While lysine may be more effective at preventing outbreaks, its impact on reducing the severity and duration of active outbreaks is less clear.
• Mechanism of action: Lysine’s antiviral effects are believed to stem from its ability to block arginine, an amino acid that promotes HSV replication.

Is lysine equally effective for all types of herpes infections? Research indicates that lysine may be more beneficial for oral herpes (cold sores) than genital herpes, but individual responses can vary. It’s important to note that while some people report significant benefits, others may not experience noticeable improvements.

Recommended Dosage for Herpes Management

What is the optimal dosage of lysine for herpes prevention and treatment? While there’s no universally agreed-upon dosage, some guidelines suggest:

• For prevention: 1,000 to 3,000 mg daily, taken in divided doses
• During an outbreak: Up to 3,000 mg daily, also in divided doses

It’s crucial to consult with a healthcare provider before starting any supplementation regimen, as individual needs and potential interactions with medications or health conditions can vary.

L-Lysine’s Potential Role in Bone Health

How might lysine contribute to maintaining strong bones? Lysine’s potential benefits for bone health stem from several mechanisms:

1. Enhanced calcium absorption: Lysine helps the body absorb calcium more efficiently from the digestive tract.
2. Reduced calcium loss: It may decrease the amount of calcium excreted in urine, helping to maintain calcium levels in the body.
3. Collagen production: Lysine is crucial for the formation of collagen, a key component of bone matrix.
4. Synergy with other nutrients: When combined with L-arginine, lysine may enhance the activity of bone-building cells and stimulate collagen production.

While these mechanisms are promising, it’s important to note that human studies specifically examining lysine’s role in preventing osteoporosis are limited. More research is needed to fully understand its potential in this area.

L-Lysine and Calcium Absorption

How does lysine enhance calcium absorption? Lysine is thought to improve calcium absorption through several pathways:

• Increasing intestinal calcium transport
• Enhancing the retention of absorbed calcium
• Potentially influencing the production of hormones involved in calcium metabolism

This improved calcium absorption and retention may contribute to better bone mineralization and strength, particularly when combined with adequate calcium intake and other bone-supporting nutrients.

L-Lysine for Athletic Performance and Muscle Recovery

Can lysine supplementation benefit athletes and fitness enthusiasts? While research is ongoing, lysine may offer several advantages for those engaged in regular physical activity:

1. Protein synthesis: As a building block of protein, lysine is crucial for muscle repair and growth.
2. Energy production: Lysine’s role in carnitine synthesis may support energy metabolism during exercise.
3. Recovery support: Some studies suggest lysine may help reduce muscle damage and inflammation after intense physical activity.
4. Immune function: Lysine’s involvement in antibody production may help maintain immune health in athletes undergoing rigorous training.

How much lysine do athletes need? The optimal dosage can vary based on factors such as body weight, activity level, and overall diet. Some general guidelines suggest:

• For maintenance: 1 to 3 grams daily
• For increased demands: Up to 6 grams daily, divided into multiple doses

As with any supplement, it’s advisable to consult with a sports nutritionist or healthcare provider to determine the most appropriate dosage for individual needs.

Safety and Precautions with L-Lysine Supplementation

Is lysine supplementation safe for everyone? While lysine is generally considered safe for most people when taken in appropriate doses, there are some considerations:

• Potential side effects: High doses may cause gastrointestinal discomfort, including nausea, abdominal pain, and diarrhea.
• Interactions: Lysine may interact with certain medications, particularly those used to treat osteoporosis or calcium supplements.
• Pregnancy and breastfeeding: Pregnant or nursing women should consult their healthcare provider before taking lysine supplements.
• Kidney or liver disease: Individuals with these conditions should use caution and seek medical advice before supplementing with lysine.

What is the upper limit for lysine intake? While there is no established upper limit, most studies have used doses ranging from 1 to 3 grams daily without significant adverse effects. However, it’s always best to start with lower doses and increase gradually if needed, under the guidance of a healthcare professional.

Monitoring Lysine Intake

How can one ensure they’re getting the right amount of lysine? For most healthy individuals consuming a balanced diet, lysine deficiency is rare. However, those considering supplementation can:

1. Track dietary intake: Keep a food diary to estimate lysine consumption from natural sources.
2. Consult a nutritionist: Get personalized advice on whether supplementation is necessary based on individual dietary patterns and health goals.
3. Regular check-ups: Include amino acid levels in routine blood work to monitor overall protein status.
4. Be aware of symptoms: Pay attention to any unusual symptoms that might indicate excessive intake or potential interactions.

Future Research and Potential Applications of L-Lysine

What areas of lysine research show promise for future applications? Ongoing studies are exploring lysine’s potential in various health domains:

• Cancer research: Some preliminary studies suggest lysine may have anti-cancer properties, particularly in combination with other amino acids.
• Cardiovascular health: Lysine’s role in carnitine production may have implications for heart health and cholesterol management.
• Diabetes management: Research is investigating lysine’s potential to improve glucose tolerance and insulin sensitivity.
• Cognitive function: Some studies are exploring lysine’s impact on brain health and cognitive performance, especially in combination with other nutrients.
• Skin health: Given its role in collagen production, lysine is being studied for potential benefits in skin aging and wound healing.

As research progresses, our understanding of lysine’s diverse roles in human health continues to expand, potentially leading to new therapeutic applications and nutritional strategies.

Personalized Nutrition and Lysine

How might advances in personalized nutrition impact lysine recommendations? The growing field of nutrigenomics and personalized nutrition may lead to more tailored approaches to lysine intake:

1. Genetic testing: Identifying genetic variations that affect lysine metabolism and utilization.
2. Biomarker analysis: Using specific biomarkers to assess individual lysine needs and response to supplementation.
3. Microbiome considerations: Understanding how gut microbiota influence lysine absorption and metabolism.
4. Lifestyle integration: Developing lysine recommendations that account for factors like stress levels, exercise habits, and overall health status.

These advancements may allow for more precise and effective use of lysine in both preventive health strategies and targeted therapeutic interventions.

Lysine Information | Mount Sinai

Amino acid K; L-lysine

Lysine, or L-lysine, is an essential amino acid, meaning it is necessary for human health, but the body cannot make it. You have to get lysine from food or supplements. Amino acids like lysine are the building blocks of protein. Lysine is important for proper growth, and it plays an essential role in the production of carnitine, a nutrient responsible for converting fatty acids into energy and helping lower cholesterol. Lysine appears to help the body absorb calcium, and it plays an important role in the formation of collagen, a substance important for bones and connective tissues including skin, tendons, and cartilage.

Most people get enough lysine in their diet. Although athletes, burn patients, and vegans who do not eat beans may need more. If you do not have enough lysine, you may experience:

• Fatigue
• Nausea
• Dizziness
• Loss of appetite
• Agitation
• Bloodshot eyes
• Slow growth
• Anemia
• Reproductive disorders

For vegans, legumes (beans, peas, and lentils) are the best sources of lysine.

Uses

Herpes simplex virus (HSV)

Some studies suggest that taking lysine on a regular basis may help prevent outbreaks of cold sores and genital herpes. Others show no improvement. Lysine has antiviral effects by blocking the activity of arginine, which promotes HSV replication. One review found that oral lysine is more effective atpreventing an HSV outbreak than it is at reducing the severity and duration of an outbreak. One study found that taking lysine at the beginning of a herpes outbreak did not reduce symptoms. Most experts believe that lysine does not improve the healing of cold sores. But supplementation may reduce recurrences or improve symptoms.

Osteoporosis

Lysine helps the body absorb calcium and reduces the amount of calcium that is lost in urine. Since calcium is crucial for bone health, some researchers think lysine may help prevent bone loss associated with osteoporosis. Lab studies suggest that lysine in combination with L-arginine (another amino acid) makes bone-building cells more active and enhances production of collagen. But no studies have examined whether lysine helps prevent osteoporosis in humans.

Athletic performance

Athletes sometimes use lysine as a protein supplement. Some studies suggest lysine helps muscle tissue recover after stress.

Dietary Sources

Good sources of lysine include foods that are rich in protein, such as:

• Meat, specifically red meat, pork, and poultry
• Cheese, particularly parmesan
• Certain fish, such as cod and sardines
• Eggs
• Soybeans, particularly tofu, isolated soy protein, and defatted soybean flour
• Spirulina
• Fenugreek seed

Brewer’s yeast, beans and other legumes, and dairy products also contain lysine.

Available Forms

Lysine is available in tablets, capsules, creams, and liquids, and is usually sold in the L-lysine form.

How to Take It

Pediatric

Speak with your pediatrician regarding appropriate dosages. Dosage is usually adjusted based on body weight.

Adult

Dosing depends on different factors. Talk to your doctor to determine the right dose for you.

Precautions

Because of the potential for side effects and interactions with medications, you should take dietary supplements under the supervision of a knowledgeable health care provider.

Lysine can increase the absorption of calcium. Use caution when taking large amounts of calcium while supplementing with lysine.

While lysine in the diet is considered safe, excessive doses may cause gallstones. There have also been reports of renal dysfunction, including Fanconi syndrome and renal failure.

Talk to your doctor before taking supplemental lysine if you have kidney disease, liver disease, or if you are pregnant or breastfeeding.

Possible Interactions

If you are currently being treated with any of the following medications or supplements, you should not use lysine supplements without first talking to your doctor.

Arginine: Arginine and lysine share common pathways in the body. High levels of arginine may lower lysine levels in the body.

Aminoglycoside antibiotics (gentamicin, neomycin, streptomycin, etc.): Use with lysine may increase the risk of nephrotoxicity.

Supporting Research

Beauman JG. Genital herpes: a review. Am Fam Physician. 2005 Oct 15;72(8):1527-34. Review.

Breau RH, Kokolo MB, Punjani N, et al. The effects of lysine anaolgs during pelvic surgery: a systematic review and meta-analysis. Transfus Med Rev. 2014;28(3):145-55.

Dietary Guidelines for Americans 2005. Rockville, MD: US Dept of Health and Human Services and US Dept of Agriculture; 2005.

Fini M, Torricelli P, Giavaresi G, Carpi A, Nicolini A, Giardino R. Effect of L-lysine and L-arginine osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001;55(4):213-220.

Gaby AR. Natural remedies for Herpes simplex. Altern Med Rev. 2006 Jun;11(2):93-101. Review.

Krymchantowski AV, Barbosa JS, Cheim C, Alves LA. Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study. Arq Neuropsiquiatr. 2001;59(1):46-49.

Rakel D. Integrative Medicine. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012.

Rao M, Chinnasamy N, Hong JA, et al. Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res. 2011;71(12):4129204.

Singh BB, Udani J, Vinjamury SP, et al., Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev. 2005;10(2):123-7.

Tfelf-Hansen P. The effectiveness of combined oral lysine acetylsalicylate and metoclopramide in the treatment of migraine attacks. Comparison with placebo and oral sumatriptan. Funct Neurol. 2000;15(Suppl 3):196-201.

4 Impressive Health Benefits of Lysine

Lysine is an amino acid that is found mostly in animal products. Though more research is needed, it may help reduce anxiety, prevent cold sores, improve calcium absorption, and promote wound healing.

Lysine is a building block for protein. It’s an essential amino acid because your body cannot make it, so you need to obtain it from food (1).

It’s important for normal growth and muscle turnover and used to form carnitine, a substance found in most cells of your body. What’s more, lysine helps transport fats across your cells to be burned for energy (2).

L-lysine is the form of lysine your body can utilize. It’s naturally found in food and is the type used in supplements.

Here are 4 impressive health benefits of lysine.

1. May protect against and treat cold sores by blocking arginine

Cold sores or fever blisters are symptoms of an infection, often appearing on the lip or the corners of your mouth (3).

They appear as fluid-filled blisters that can cause discomfort, such as tingling, pain, and burning (3).

Cold sores are caused by the herpes simplex virus type 1 (HSV-1), which can hide in your spine. In times of stress or if your immune system is weakened, HSV-1 can trigger the development of a cold sore (3).

According to some research, lysine supplements may help prevent HSV-1 from replicating and reduce the duration of a cold sore. It’s thought that lysine blocks another amino acid called arginine, which viruses need in order to multiply (4).

However, studies have turned up mixed results on the effects of lysine on HSV-1.

For example, one review found that supplementing with less than 1 gram (g) of lysine per day was ineffective for preventing cold sores in people who were consuming enough arginine in their diet, but taking doses over 3 g per day was able to improve symptoms of cold sores (5).

Furthermore, not all studies show that lysine is effective in reducing cold sore occurrence or duration. In fact, one review found insufficient evidence to recommend it for treating cold sores (6).

summary

Some studies suggest that lysine may help reduce the duration and frequency of cold sores, but the evidence is inconsistent.

Lysine may play a role in reducing anxiety.

One 2003 study found that it blocked receptors involved in stress response. Researchers observed that rats given lysine had reduced rates of stress-induced loose bowel movements (7).

Another older study in 50 people showed that supplementing with 2.64 g of lysine and arginine lowered stress-induced anxiety and reduced levels of the stress hormone cortisol after 1 week (8).

Similarly, an older study found that adding 4.2 g of lysine to each kilogram (kg), or 2.2 pounds (lbs.), of wheat flour in villages in Syria helped reduce anxiety scores in males with very high stress levels (9).

After 3 months, consuming the lysine-enriched flour also helped reduce cortisol levels in females (9).

Lysine may also be able to help people with schizophrenia, a mental disorder that disrupts an individual’s perception of the outside world, resulting in changes in thought and behavior (10).

Though research is still in its early stages and is limited to mostly older studies, lysine may have the potential to improve schizophrenia symptoms in combination with prescribed medication (11, 12).

summary

Lysine may help reduce feelings of anxiety and reduce levels of the stress hormone cortisol in some people. Early research indicates that it may even help improve symptoms in people with schizophrenia.

Lysine may help your body hold on to calcium (13).

It’s believed that lysine increases calcium absorption in your gut and helps your kidneys to hold on to the mineral (14, 15).

An older study in 30 females, including 15 with osteoporosis, found that supplementing with calcium and lysine reduced the loss of calcium in the urine (15).

Those given 3 g of calcium alone had a progressive increase in calcium in their urine. However, those who also received 400 milligrams (mg) of lysine lost less calcium through their urine (15).

Lysine appears to protect your bones and may also play a part in controlling where calcium is transported in your body.

For example, it has been shown to prevent the buildup of calcium in blood vessels in rats. This kind of buildup is a risk factor for heart disease (14).

Still, more high quality, recent research in humans is needed before lysine supplementation can be recommended to support bone or heart health.

summary

Lysine may help you absorb more calcium and reduce the loss of calcium in your urine. It could even reduce the risk of calcium buildup in your blood vessels. However, more high quality, recent research in humans is needed.

Lysine can improve wound healing in your body.

In animal tissue, lysine becomes more active at the site of a wound and helps speed up the repair process (16).

Lysine is required for the formation of collagen, a protein that acts as a scaffold and helps support and give structure to skin and bones (17, 18).

Lysine itself may also act as a binding agent, thereby increasing the number of new cells at a wound. It may even promote the formation of new blood vessels (19).

In one 2011 study, applying a combination of lysine and hyaluronic acid topically was able to reduce the size of pressure ulcers more effectively than sodium hyaluronate, another medication used to enhance wound healing (20).

In another 2009 study in 40 rabbits, it was found that taking 21 mg per lb. (47 mg per kg) of body weight of lysine and 23 mg per lb. (50 mg per kg) of body weight of arginine significantly improved blood flow and overall bone healing (13).

In fact, rabbits that received lysine and arginine had a 2-week reduced healing time compared to the control group (13).

Wound healing is a complex process that requires different minerals, vitamins, and other factors. Lysine appears to have an invaluable role, and without adequate lysine, wound healing is impaired (21, 22).

To date, studies have only looked at oral lysine supplements on wound healing in animals, so more studies in humans are needed. Additionally, it’s unknown whether applying it directly onto wounds could be effective.

summary

Lysine is essential for the formation of collagen, an essential protein that affects wound repair. Some studies in humans and animals indicate that lysine may speed up wound healing and reduce recovery time, but research is still limited.

Lysine — like all amino acids — is used as a building block for protein in your body. These proteins help produce hormones, immune cells, and enzymes.

Lysine may have several benefits in addition to those discussed earlier.

Here are other areas where lysine may benefit your health:

• Cancer: One animal study found that lysine in combination with the antioxidant catechin reduced cancer cell growth in mice (23).
• Eye health: An older study in rats with diabetes found that lysine supplements could prevent the development of cataracts (24).
• Diabetes: One 2009 study showed that lysine may help reduce blood sugar response in people with diabetes. However, the connection is still unclear (25).
• Blood pressure: A study in 50 adults with lysine deficiency and high blood pressure found that lysine supplements significantly reduced blood pressure (26).

Adequate lysine is essential for maintaining normal health and supplements may benefit certain people and conditions.

summary

Research of lysine is promising, as some evidence indicates that it may have anti-cancer effects, could help improve blood sugar levels, and may reduce blood pressure.

Lysine is found in foods that are naturally high in protein, including meat and dairy products, and also in smaller amounts in plant foods (27).

Here are some great sources of lysine (27):

• Meat: beef, chicken, and lamb
• Seafood: mussels, prawns, and oysters
• Fish: salmon, cod, and tuna
• Dairy products: milk, cheese, and yogurt
• Legumes: soy, kidney beans, and chickpeas
• Nuts and seeds: pistachios, pumpkin seeds, and cashews

If you’re prone to cold sores, taking 1 g of lysine daily or using a lysine-containing gel may be worth a try, but remember that it’s best to speak to a healthcare professional first (4).

summary

Animal foods, such as meat, fish, and dairy supply the greatest amount of lysine, but you will also find decent amounts in legumes, nuts, and seeds. Fruits, vegetables, and grains are very poor sources of lysine.

Lysine is an essential amino acid with many benefits that range from preventing cold sores to reducing anxiety and promoting wound healing.

As a building block of proteins, it may also have numerous other benefits. Without enough lysine, your body may be unable to produce sufficient or appropriate hormones and immune cells.

Lysine is found in high amounts in animal products, including meat, fish, and dairy. Certain types of legumes, nuts, and seeds can also help increase your intake.

L-lysine for intestines and brain

L-lysine: useful properties, side effects

Did you know that protein can help fight a host of ailments, from herpes to cancer? And L-lysine is simply irreplaceable in its formation.

L-lysine is used to treat the herpes virus and recovery from exercise. However, this acid has many more useful properties.

L-lysine can be useful in many cases, including the treatment of anxiety and diabetes. This amino acid is present in foods and can also be purchased as a dietary supplement.

What is L-lysine?

L-lysine is an essential amino acid. Certain amino acids are known as the “building blocks of protein” and are essential for a variety of processes to function properly, including growth.

L-lysine was discovered by the German scientist Dreschel in 1889. He was able to isolate the amino acid from casein, or milk protein. Its exact structure was described three years later.

Of the hundreds of amino acids found in nature, 20 are essential for protein synthesis and growth, and only half of these twenty can be produced by the human body itself. The remaining 10 are called “essential” because a person needs to get their food to maintain health.

Amino acid deficiency can lead to degradation of internal cells and the appearance of serious health problems, which is why it is so important to monitor their abundance. Lysine and glutamine deficiencies are especially common.

Essential amino acids are usually stereoisomers, meaning they exist in two versions that are mirror images of each other. These amino acids have D- and L-forms, L-forms are used for protein synthesis, they are present in food and nutritional supplements. This nutrient is often referred to simply as “lysine”.

L-lysine has many health benefits and is used to treat cold sores and anxiety. As a dietary supplement, it can be taken orally, but this substance is best absorbed from food. It is present in high concentrations in meat, beans, cheese, and eggs.

L-lysine is very important for the production of carnitine, which converts amino acids into energy and lowers blood cholesterol levels. It also plays a role in the absorption of calcium and the production of collagen, which promotes the growth and maintenance of healthy bones and connective tissues, including skin.

Health benefits

As a natural anti-inflammatory agent, L-lysine helps the human body in several ways, many of which have been studied by scientists relatively recently.

1. May reduce the incidence of herpes

Often L-lysine is mentioned when talking about natural remedies for herpes. Herpes occurs as a result of the herpes simplex virus type 1 (HSV-1). About 67% of the world’s population under the age of 50 is infected with this virus, even if they have never experienced symptoms.

HSV-2 causes genital herpes, while 85% of carriers of this disease are not even aware of it.

Despite conflicting research on this subject, most people who use L-lysine to treat herpes find it very effective. Some studies suggest that L-lysine helps to reduce the frequency of HSV outbreaks, while others say that the frequency of occurrence is maintained, but they have observed a decrease in the period of exacerbation of the disease.

Most experts agree that L-lysine cannot cure cold sores, but it does help reduce the frequency and/or severity of cold sores.

One study using a cream that combined L-lysine, medicinal herbs and zinc showed that in 87% of patients, herpes disappeared on the sixth day of treatment. These results are particularly noteworthy, as outbreaks typically last about 21 days.

The principle according to which this substance relieves herpes is not fully understood. One reason could be an interaction with arginine, another amino acid that is produced in small amounts in the body. Arginine shows an increase in the rate of replication of herpes virus cells, and a large amount of L-lysine in the body reduces the activity of arginine.

L-lysine is able to act not only on HSV-1, but also on HSV-2, softening the course of genital herpes. However, more thorough research is needed.

2. May help treat cancer

Scientists are actively looking for natural treatments for cancer, as traditional treatments (such as chemotherapy or radiation therapy) have a strong negative effect not only on diseased cells, but also on healthy cells. Scientists have made major breakthroughs in this area, discovering many ways to use nutrients found in food and the environment for therapeutic purposes, in particular, to kill malignant cells bypassing healthy ones.

In 2007, scientists from Florida State University, USA, studied the effect of “lysine conjugates” on damaged DNA strands, similar to those present in cancer. It turned out that this substance can find a damaged thread by identifying a “split” (damaged section) in it and separating the rest of the thread. The cell, as a rule, is not able to repair this damage, so apoptosis, cell death, occurs.

The more we learn about lysine, the better we understand how effective it can be in the treatment of cancer. The anti-cancer properties of lysine conjugates are only activated when exposed to certain types of light. This allows scientists and physicians to apply treatments precisely and directly to cancer cells, activating substances where they are needed.

Florida State University scientists found between 25% and 90% of destroyed cancer cells. These are amazing results!

The action of lysine oxidase was studied in 2014 using colorectal cancer in mice. In this study, injections of lysine oxidase resulted in zero mortality and a significant reduction in large tumors. The results point to this substance as a promising agent for the treatment of colorectal cancer in the future.

According to preliminary studies, bone marrow-related cancers such as leukemia may also be susceptible to L-lysine treatment. Scientists believe that injections of L-lysine help prevent genotoxicity (DNA and RNA damage) in cells exposed to pro-cancer substances.

3. Combats anxiety and other psychological symptoms

In addition to eating foods rich in B vitamins, magnesium, and omega-3 fatty acids, taking L-lysine can also help relieve anxiety. One of the main principles of treating anxiety with L-lysine is that it promotes the absorption of calcium, which calms the nervous system.

In addition to more efficient absorption of calcium, L-lysine acts as a serotonin receptor antagonist. This means that it partially binds to serotonin receptors, preventing the development of feelings of anxiety.

So, one study found that L-lysine helps to reduce the anxiety response caused by stress (including diarrhea).

This is especially important in countries where wheat is the staple food. In such countries, people suffer from L-lysine deficiency much more often.

Scientists believe that dietary modifications in countries with high wheat consumption can help reduce stress-induced anxiety and, as a result, diarrhea.

L-lysine may be effective in treating schizophrenia, which is one of the most serious consequences of anxiety. Preliminary research suggests that L-lysine supplementation with conventional therapy may reduce symptoms of schizophrenia. However, it is worth noting that the recommended dosage and duration of treatment have not yet been established.

4. Promotes calcium absorption

L-lysine intake has been linked to increased calcium absorption, bone protection, and a reduced risk of osteoporosis. At the moment, there have been no significant studies on the relationship between L-lysine and osteoporosis. However, it is logical to assume that by increasing the amount of calcium, L-lysine can be beneficial for bone health.

In fact, calcium isn’t just for bones. Sufficient calcium intake is associated with:

• Normal weight
• Cancer Prevention
• Relief of PMS symptoms
• Dental health
• Strong muscles
• Healthy nervous system
• Prevention of diabetes

Athletes often take L-lysine as an endurance supplement. This may also be due to the fact that L-lysine promotes calcium absorption.

5. Combats the complications of diabetes

All patients with diabetes face an increased risk of infection and other problems. Recently, more and more attention has been paid to the presence of advanced glycation end products (AGEs).

These AGEs are involved in the aging process, but they are especially present in diabetic patients. They are associated with many diseases caused by diabetes, which led scientists to start looking for ways to prevent the accumulation of AGEs in the body.

Research suggests that L-lysine may help slow the formation of AGEs in diabetics by blocking the specific glycation pathways that produce them. This will help protect the body from infection. Thus, it is essential to include L-lysine in the form of foods or dietary supplements in a diabetic diet.

6. Supports intestinal health

Leaky Gut Syndrome is a very common ailment that many do not even know about. In this disease, the lining of the digestive tract allows larger particles to exit the digestive system and enter other parts of the body. This causes allergic reactions, loss of energy, joint pain, autoimmune disease, and thyroid problems.

Recently, a form of L-lysine called poly-L-lysine has been found to have an anti-inflammatory effect on the intestinal surface. Of course, further research is needed to understand exactly how this amino acid can improve gut health and prevent leaky gut syndrome.

It is also known that L-lysine inhibits the development of pancreatitis, an inflammation of the pancreas.

Food sources

The most effective way to maintain high levels of lysine in the body is to consume foods rich in this amino acid.

It should be noted, however, that traditional methods of food preparation can reduce their nutritional value. Such methods include reduction with sugar-containing substances, heating in the presence of yeast or sucrose, processing in the absence of liquid.

The following foods have the highest lysine content:

1. Lean beef and lamb – 3,582 mg/100 grams (171% of the RDA)
2. Parmesan Cheese – 3,306mg/100g (157% RDA)
3. Turkey & Chicken – 3 110mg/100g (148% RDI)
4. Pork – 2,757mg/100g (131% RDA)
5. Roasted Soybeans – 2,634mg/100g (125% RDA)
6. Tuna – 2,590mg/100g (123% RDA)
7. Shrimp – 2,172mg/100g (103% RDA)
8. Pumpkin Seeds – 1,386 mg/100 grams (66% of RDI)
9. Eggs – 912 mg/100 grams (43% of the RDA)
10. White Beans – 668 mg/100 grams (32% of RDI)

While all of these foods are rich in lysine, we recommend avoiding pork, soy, and shrimp whenever possible, as they often contain toxins. As for other types of meats, cheeses and eggs, make sure you have high quality organic products on your table.

Dosage

All nutrients are always best obtained from food, not from supplements. In this case, your body receives more substances without the risk of overdose.

However, dietary supplements can be very helpful when you cannot get the recommended amount of a certain substance from food.

The average person (weighing about 70 kg) should get 800 to 3,000 mg of L-lysine each day.

For herpes, its amount in the form of a dietary supplement should be 1-3 grams daily. Lysine is also available in the form of a cream that is applied directly to the cold sore area.

Risks and side effects

Supplementation with L-lysine is associated with a number of minor side effects, while the dangers of dietary lysine have not been proven. These side effects include stomach pain and diarrhea.

There has also been one case of lysine-related kidney disease, for this reason, people suffering from kidney and liver disease should take L-lysine with caution and under the supervision of a specialist.

Women who are pregnant or breastfeeding should avoid lysine supplementation, as scientists do not yet have sufficient information about the effects of L-lysine supplementation on women during this period.

Despite the positive effect on a number of diseases, there is information that L-lysine can increase the viral load in patients with HIV. We advise people with HIV/AIDS to avoid supplemental L-lysine entirely and only get it from food (it probably doesn’t work that way).

However, scientists have also noticed that this property can be used to speed up the testing of HIV treatments.

Final Conclusions

• L-lysine, or the L-form of lysine, is required by the body for protein synthesis. This essential amino acid is not produced by humans and can only be obtained from foods and/or supplements. L-lysine is also available as a topical cream.
• L-lysine is most commonly used to treat the herpes simplex virus. However, it has a number of properties that help it fight cancer by reducing the size of neoplasms and causing the death of cancer cells without damaging healthy ones.
• Consuming foods rich in lysine is the most effective way to increase your body’s amino acid levels and get the most out of it.
• An average person needs 800-3,000 mg of L-lysine per day.

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Lysine – all information about the supplement, benefits

August 30
2022

Among the essential amino acids in the human body, lysine deserves special attention. Lysine is one of the key building blocks for protein production. This is one of the essential amino acids that is not produced independently in the body, so there is a need to make it through the use of special supplements or through products. The amino acid lysine is very important for the body, as it has a large number of undeniable benefits.

Signs of deficiency

Lysine is a substance that a person receives in the required amount for the body through the consumption of certain foods. But sometimes deficiency can be observed, which is manifested by the following symptoms:

• significant loss of appetite;
• nausea;
• slow growth;
• presence of reproductive disorders;
• signs of anemia;
• dizziness;
• eyes that are bloodshot;
• excessive fatigue.

If symptoms appear, this may indicate a lack of lysine in the human body.

Daily Value

Lysine is a substance that can be consumed not only in its usual form, but also by application to the surface of the skin.

Important! On the part of the researchers, it was found that for a person whose average weight is 70 kg, about 800-3000 mg of the substance should be consumed per day.

An adult needs about 12 mg of lysine per 1 kg of body weight. For a child per 1 kg of body weight over 12 years old, about 44 mg are needed. If we consider the age from 3 to 6 months, then 97 mg of lysine is needed per 1 kg of body.

How does lysine affect the body?

From such an amino acid as lysine, the benefits for the human body are undeniable. First of all, it can contribute to a significant growth of muscle fibers and their effective recovery. Also, lysine is involved in the synthesis of carnitine, which acts as a connecting element between a large number of cells. Through this amino acid, fats are transported, which are subsequently converted into energy, with the help of which all systems and organs of the body work.

Treatment of herpes with lysine

An infectious disease such as herpes occurs in about 80% of people worldwide at least once in a lifetime. Lysine in herpes helps to reduce the manifestations of the symptoms of this disease with the possibility of significantly accelerating the treatment process. This effect is provided due to the fact that the amino acid prevents the production of arginine in the body. It is arginine that is the main element that contributes to the reproduction of the virus.

Anxiety Reduction

Lysine is an amino acid that can reduce anxiety levels that a person has. Such conclusions were drawn from studies where lysine was used to reduce stress levels. The experiment was carried out for a week, in which perfectly healthy people were given 2.64 g of lysine per 1 kg of body weight. It was noticed that during the week the level of cortisol, which acts as a stress hormone, decreased significantly.

Improved Calcium Absorption and Retention

When asked what lysine is used for, doctors have noticed that this essential amino acid contributes to the significant retention and absorption of such an important structural element as calcium. This is due to the fact that the presented microelement is well absorbed in the intestines and is subsequently retained directly with the help of the kidneys. Special studies were conducted, in which about 30 representatives of the weaker sex took part, among which half were with osteoporosis. It was noticed that with the use of lysine in a volume of 400 mg daily, the level of calcium in the body increased significantly.

Improves the process of collagen production with further acceleration of regeneration

When asking what l lysine is used for, it is worth remembering that it helps in the rapid process of tissue regeneration. It has also been observed that the amino acid is the main component necessary for the synthesis of collagen, which acts as the main protein compound. This further helps to strengthen the bones and skin. In the course of the research, it was found that the combination of lysine together with arginine significantly accelerated the healing process of tissues and bones that were damaged.

Other useful properties of lysine

Considering what lysine is used for, it is worth paying attention to the fact that it helps in the production of enzymes, hormones, and also to ensure the activity of many important systems of the human body. For example, l lysine for immunity helps to recover from viral and infectious diseases as quickly as possible.

Among other medicinal properties, the following are distinguished:

1. significant help in the treatment of cancer;
2. normalization of blood sugar levels, which helps fight diabetes;
3. lysine helps fight serious eye diseases;
4. the ability to normalize blood pressure.

Scientists have found that the constant ingestion of lysine in the human body leads to the possibility of eliminating the symptoms of many diseases.

Best sources of lysine

If we consider the best sources that contain lysine, then various protein products should be attributed to them. If it is not possible to obtain lysine through ordinary food, then you can resort to the use of special additives, which include the active form of the presented amino acid.

Lysine in foods – where it is found

Lysine is found quite often in foods. These include the following:

• seafood – here the main focus should be on shrimp, all kinds of mussels and various oysters;
• meat – this may be chicken, pork or beef;
• dairy products – the largest amount of this amino acid in milk, in the composition of kefir and various cheeses;
• fish – a storehouse of lysine are cod, fish of the salmon family and tuna;
• legumes – chickpeas and soy directly can be distinguished here;
• various vegetable and fruit products – this can be Bulgarian pepper, potatoes, avocados, dried apricots, pears;
• nuts – the most expensive macadamia nut.

All of the products listed above contain the amino acid lysine in the highest possible quantity.

Consequences of lack of L-lysine

As practice shows, a person receives a large amount of lysine with ordinary food. But often there can also be a lack of this amino acid, which will manifest itself in loss of appetite, nausea, anemia, serious reproductive disorders, fatigue and dizziness.