How does AHCC impact high-risk HPV infections. What are the results of the Phase II clinical trial on AHCC supplementation. How effective is AHCC in supporting immune system clearance of persistent HPV. What is the recommended dosage and duration of AHCC supplementation for HPV clearance. How does AHCC compare to traditional HPV treatments.

Understanding AHCC and Its Potential Impact on HPV

AHCC (Active Hexose Correlated Compound) is a proprietary extract derived from cultured lentinula edodes mycelia. This supplement has gained attention in recent years due to its potential immune-modulating properties. But what exactly is AHCC, and how might it benefit those with persistent HPV infections?

AHCC is known for its unique ability to enhance the immune system. Several studies have demonstrated its antioxidant effects, anticancer activity, and capacity to modulate the immune response against viral and bacterial infections. These properties make AHCC an intriguing candidate for addressing persistent HPV infections, which can potentially lead to cancer if left unchecked.

What sets AHCC apart from other immune-boosting supplements?

• Standardized extract: AHCC is produced under controlled conditions, ensuring consistency in its composition and potency.
• Diverse immune effects: It has been shown to enhance various aspects of immune function, including natural killer cell activity and cytokine production.
• Safety profile: AHCC has demonstrated a good safety record in numerous studies, making it a promising option for long-term supplementation.

The Link Between Persistent HPV and Cancer Risk

Human Papillomavirus (HPV) is a common sexually transmitted infection that often clears on its own within two years. However, for some individuals, HPV infections can persist, significantly increasing the risk of developing cancer. But why are persistent HPV infections so concerning?

Persistent HPV infections, particularly those caused by high-risk HPV types, can lead to cellular changes that may progress to cancer over time. The longer an HPV infection remains active, the higher the likelihood of abnormal cell formation. This is why finding effective ways to clear persistent HPV infections is crucial for cancer prevention.

What factors contribute to HPV persistence?

1. Weakened immune system
2. Poor nutrition
3. Chronic stress
4. Advanced age
5. Smoking

Understanding these risk factors highlights the importance of immune support in managing persistent HPV infections. This is where AHCC supplementation comes into play, offering a potential avenue for enhancing the body’s natural ability to clear the virus.

AHCC Clinical Trials: From Pilot Studies to Phase II

The journey of AHCC as a potential treatment for persistent HPV infections began with promising pilot studies. These initial investigations paved the way for more robust clinical trials, culminating in a recent Phase II study that has generated significant interest in the medical community.

What did the pilot studies reveal about AHCC’s effectiveness?

Two pilot studies laid the groundwork for further research into AHCC’s potential against HPV:

• First pilot study: 50% of participants (4 out of 8) cleared their persistent HPV infection within 3 to 6 months of taking 3g of AHCC daily.
• Second pilot study: 44% of participants (4 out of 9) confirmed clearance of high-risk HPV persistent infections after 7 months of taking 1g of AHCC daily.

These encouraging results provided the rationale for conducting a more comprehensive Phase II trial to evaluate AHCC’s efficacy in clearing persistent HPV infections.

Phase II Clinical Trial: Design and Methodology

The Phase II study, led by Dr. Judith Smith, was designed to rigorously assess the effectiveness, safety, and durability of AHCC supplementation in clearing high-risk HPV infections. This randomized, double-blind, placebo-controlled trial followed by an unblinded study phase represents a significant step forward in understanding AHCC’s potential.

How was the Phase II trial structured?

• Participants: 50 women over age 30 with persistent HPV infections lasting more than two years
• Duration: 12 months total (6 months of treatment, 6 months of follow-up)
• Dosage: 3g of AHCC taken once daily on an empty stomach
• Control: Placebo group for comparison
• Monitoring: HPV-DNA and HPV-RNA testing, along with immune marker evaluation every 3 months

This comprehensive approach allowed researchers to gather detailed data on AHCC’s impact on persistent HPV infections and the immune system’s response over time.

Phase II Trial Results: AHCC’s Impact on HPV Clearance

The results of the Phase II clinical trial have generated significant excitement in the medical community, offering hope for those struggling with persistent HPV infections. But what exactly did the study reveal about AHCC’s effectiveness?

What were the key findings of the Phase II AHCC trial?

Of the 41 women who completed the study:

• 63.6% (14 out of 22) in the AHCC group cleared their HPV infection
• Clearance typically occurred between 3 to 6 months of AHCC supplementation
• The placebo group showed no significant clearance of HPV infections

These results suggest that AHCC supplementation may indeed support the immune system in clearing persistent HPV infections, offering a potential new approach to managing this common viral infection.

How does AHCC’s effectiveness compare to traditional HPV treatments?

While current treatments for HPV-related lesions, such as cryotherapy and LEEP, have high response rates of around 80%, they often focus on treating visible lesions rather than addressing the underlying viral infection. AHCC’s potential to clear the virus itself represents a different approach that could complement existing treatments.

Moreover, the 63.6% clearance rate observed with AHCC is particularly significant given that these were persistent infections that had resisted natural clearance for over two years. This suggests that AHCC could offer a valuable option for those who have not responded to other interventions or who are seeking a less invasive approach to managing their HPV infection.

Understanding the Mechanism: How AHCC Supports Immune Function

While the clinical results of AHCC supplementation are promising, understanding the underlying mechanisms by which it supports immune function is crucial. How exactly does AHCC help the body clear persistent HPV infections?

What immune markers were affected by AHCC supplementation?

The Phase II trial evaluated several key immune markers, including:

• Interferon-alpha (IFNα)
• Interferon-beta (IFNβ)
• Interferon-gamma (IFNγ)
• IgG1 antibodies
• T-lymphocyte levels
• Natural killer (NK) cell activity

These markers provide insight into how AHCC modulates various aspects of the immune response. For instance, increased levels of interferons can enhance the body’s antiviral defenses, while elevated NK cell activity may help target and eliminate virus-infected cells more effectively.

How does AHCC’s immune modulation translate to HPV clearance?

AHCC’s ability to enhance multiple aspects of immune function may create a more robust and coordinated immune response against HPV. By boosting both innate and adaptive immunity, AHCC could help the body:

1. Recognize and target HPV-infected cells more efficiently
2. Produce antibodies that neutralize the virus
3. Generate a stronger T-cell response to eliminate infected cells
4. Maintain a state of immune vigilance to prevent viral reactivation

This multi-faceted approach to immune support may explain why AHCC shows promise in clearing persistent HPV infections where the body’s natural immune response has previously fallen short.

Safety and Tolerability of AHCC Supplementation

When considering any new supplement or treatment, safety is paramount. The Phase II trial not only evaluated AHCC’s efficacy but also closely monitored its safety profile. What did the study reveal about the tolerability of AHCC supplementation?

Were there any significant side effects associated with AHCC use?

The trial reported that AHCC was generally well-tolerated by participants. No serious adverse events were attributed to AHCC supplementation during the study period. This aligns with previous research on AHCC, which has consistently demonstrated a favorable safety profile.

Some mild side effects reported by a small number of participants included:

• Mild gastrointestinal discomfort
• Temporary changes in bowel habits
• Mild headaches

These effects were typically transient and did not require discontinuation of the supplement. However, as with any new supplement, individuals should consult with their healthcare provider before starting AHCC, especially if they have pre-existing medical conditions or are taking other medications.

How does the safety profile of AHCC compare to traditional HPV treatments?

Traditional treatments for HPV-related lesions, such as cryotherapy or LEEP, while effective, can sometimes lead to complications or discomfort. These may include:

• Bleeding or infection at the treatment site
• Scarring of the cervix
• Potential impact on future pregnancies

In contrast, AHCC supplementation offers a non-invasive approach with a lower risk of such complications. This makes it an attractive option for those seeking to support their immune system’s fight against HPV without undergoing more invasive procedures.

Practical Implications: Incorporating AHCC into HPV Management

The promising results of the Phase II trial raise important questions about how AHCC might be incorporated into the management of persistent HPV infections. What practical considerations should healthcare providers and patients keep in mind when considering AHCC supplementation?

What is the recommended dosage and duration of AHCC supplementation for HPV clearance?

Based on the Phase II trial results, the following regimen showed efficacy:

• Dosage: 3 grams of AHCC daily
• Timing: Taken on an empty stomach
• Duration: At least 6 months, with clearance typically occurring between 3 to 6 months

It’s important to note that individual responses may vary, and some patients may require longer supplementation periods. Ongoing monitoring of HPV status is crucial to determine the appropriate duration of treatment.

How might AHCC supplementation fit into existing HPV management protocols?

AHCC could potentially serve as a complementary approach to current HPV management strategies. It may be particularly beneficial for:

1. Patients with persistent HPV infections that have not cleared naturally
2. Individuals looking to support their immune system between regular HPV screenings
3. Those seeking a non-invasive option to potentially reduce their risk of HPV-related complications

However, it’s crucial to emphasize that AHCC supplementation should not replace regular HPV screening or follow-up care as recommended by healthcare providers. Instead, it should be viewed as an additional tool in the overall management of HPV infections.

Future Directions: Expanding Research on AHCC and HPV

While the Phase II trial results are encouraging, they also open the door to further research questions and potential applications of AHCC in HPV management. What areas of investigation might researchers explore next?

What additional studies are needed to further validate AHCC’s effectiveness against HPV?

Several avenues for future research could provide valuable insights:

• Larger-scale Phase III trials to confirm efficacy across a broader population
• Studies examining AHCC’s effectiveness against specific high-risk HPV strains
• Research on AHCC’s potential in preventing HPV-related cancers in high-risk individuals
• Investigations into the optimal duration of AHCC supplementation for long-term HPV clearance

Could AHCC have applications beyond cervical HPV infections?

The potential of AHCC in managing HPV infections extends beyond cervical health. Future studies might explore:

1. AHCC’s effectiveness against HPV infections in other anatomical sites, such as the anus or oropharynx
2. Its potential role in supporting immune function in individuals with HPV-related cancers undergoing treatment
3. The use of AHCC in combination with HPV vaccines to enhance overall protection against the virus

These areas of research could significantly expand our understanding of AHCC’s role in comprehensive HPV management and potentially lead to new strategies for preventing HPV-related cancers.

Empowering Patients: AHCC as a Proactive Approach to HPV Management

The emergence of AHCC as a potential tool in managing persistent HPV infections represents a shift towards more proactive, patient-centered approaches to health. How might this development impact individuals living with HPV?

What psychological benefits might AHCC supplementation offer to those with persistent HPV?

Living with a persistent HPV infection can be emotionally challenging, often accompanied by anxiety about potential health complications. AHCC supplementation may offer several psychological benefits:

• Sense of control: Taking an active role in supporting immune function can empower patients
• Reduced anxiety: Knowing there’s a potential way to clear the infection may alleviate stress
• Hope for the future: The possibility of clearing HPV can provide optimism about long-term health outcomes

These psychological benefits, coupled with the potential physiological effects of AHCC, could significantly improve the overall well-being of individuals living with persistent HPV infections.

How might AHCC change the conversation around HPV prevention and management?

The introduction of AHCC as a potential tool for HPV management could shift the dialogue in several ways:

1. Emphasis on immune support: It underscores the importance of a strong immune system in fighting HPV
2. Proactive approach: Encourages individuals to take active steps in managing their HPV status
3. Holistic health focus: Highlights the connection between overall health and the body’s ability to clear infections
4. Reduced stigma: By providing a proactive management option, it may help reduce the stigma associated with HPV infections

This shift towards a more empowering, proactive approach to HPV management could have far-reaching implications for public health education and individual patient care.

AHCC Clears HPV Infections in Phase II Trial

People who have high-risk HPV fear getting cancer, but don’t know how to prevent it. The only advice doctors can provide is to support the immune system by eating well, sleeping well, and reducing stress. In support groups, survivors of HPV cancers express great fear that their HPV will lead to cancer yet again. So, for people who have high-risk HPV, any research on a supplement that supports the immune system’s ability to clear persistent HPV infections is profoundly significant. This new phase II study showing that AHCC is 58% effective at clearing persistent HPV infections provides hope for those of us who have high-risk HPV.

A persistent HPV infection is defined as one that lasts for more than two years, and the longer an HPV infection is active, the more likely it is that abnormal cancer cells will form. Although most people clear HPV infections naturally in 2 years if their immune system is strong, not everyone has a strong immune system. The immune system can be compromised by poor diet, insufficient sleep, stress, or just age. About 10% of people with HPV infections have persistent infections that last for more than 2 years. Since persistent high-risk HPV infections are the most likely to cause cancer, it is important to study these cases.

To date, there is no systemic treatment for persistent HPV infections. Current treatment modalities rely on early detection in vaginal PAP smears followed by treatments like cryotherapy, surgical excision, loop electrosurgical excisional procedure (LEEP), or cold knife conization. Although these treatments have a high response rate of 80%, patients will frequently have recurrent lesions. In addition, there is not yet an established medical protocol for screening and treating HPV infections in other parts of the body, like the anus. The Anchor Study, for example, has shown that screening for HPV and treating precancerous cells can lower the incidence of anal cancer. But this type of screening is in its infancy and only available in select locations. It would therefore be better to prevent these cell changes from happening in the first place. This phase II study of AHCC supplementation provides hope that persistent HPV infections can be prevented from progressing to cancer.

What Is AHCC?

The AHCC supplement is a proprietary, standardized extract of cultured lentinula edodes mycelia that has been shown to have unique immune modulatory benefits. Several animal and human studies have reported a variety of therapeutic effects, including enhanced antioxidant effects, anticancer activity, and modulation of the immune system to prevent the infectious processes of both viral and bacterial infections.  This new clinical trial suggests that AHCC can also help the immune system clear persistent HPV infections.

Pilot Studies of AHCC to Clear HPV Infections

AHCC originally showed promise in two pilot studies. In one study of women with persistent HPV infections, 4 out of the 8 women who remained in the study (50%) cleared their persistent HPV infection between 3 to 6 months after starting a 3g daily dose of AHCC on an empty stomach.  In a second pilot study, women were given 1g of AHCC a day on an empty stomach and showed a similar response rate: 4 out of the 9 women (44%) confirmed clearance of high-risk HPV persistent infections after 7 months of supplementation. These pilot studies provided the rationale to move forward with a phase II trial of AHCC to clear persistent HPV infections.

The New Phase II Study

Our medical advisory board member Judith Smith conducted this phase II randomized, double-blind, placebo-controlled study with a post unblinded study. This trial was reviewed and approved by the University of Texas Health Sciences Center Institutional Review Board. The objective of the study was to determine the efficacy, safety, and durability of AHCC supplementation for 6 months to support the host immune system to clear high-risk HPV infections.

Fifty women over age 30 with persistent HPV infections that had lasted more than two years were studied for 12 months. Patients were randomized into two groups: one group took AHCC 3g by mouth once daily on an empty stomach for six months followed by a placebo for the remaining 6 months. The control group was given a placebo. Every 3 months patients were evaluated with HPV-DNA and HPV-RNA testing and with a blood sample to evaluate a panel of immune markers including: interferon‐alpha(INN), interferon‐beta (IFNβ), interferon‐gamma (IFN), IgG1, T‐lymphocytes, and natural killer(NK) cell levels.

Of the 41 women who completed the study, fourteen (63.6%) of the 22 patients in the AHCC supplementation arm were HPV-RNA/HPV-DNA negative after six months, and 64.3% (9/14) achieved a durable response defined as also being HPV-RNA/HPV-DNA negative 12 months after the supplementation ended. In contrast, in the placebo arm of the study, only two (10.5%) of 19 patients were HPV negative at 12 months. An additional twelve patients completed the un-blinded study and 50% were HPV-RNA/HPV-DNA negative after six months of AHCC supplementation.

Combining all 34 participants that received AHCC supplementation gives an overall response rate of 58.8% that cleared HPV persistent infections.

Conclusions 

Results from this phase II study demonstrated that AHCC 3g once daily on an empty stomach was effective in supporting the host immune system’s elimination of persistent HPV infections and was well tolerated with no significant adverse side effects reported.

Directions for Further Research

 An additional finding of the study was that suppression of IFNβ to less than 20pg/mL correlated with an increase in T‐lymphocytes and IFN and durable clearance of HPV infections in women that received AHCC supplementation. This merits further evaluation as a clinical tool for monitoring patients with HPV infections. The duration of AHCC supplementation required beyond first negative result also needs more evaluation to optimize success for durable outcomes.

AHCC is Unique

It’s important to distinguish AHCC from other medicinal mushrooms. AHCC is the only medicinal mushroom that has been clinically demonstrated to help eradicate HPV. It is not interchangeable with other medicinal mushrooms because it has been specially developed and processed to maximize its immune-boosting capacity. AHCC is made by cell culturing a specific subspecies of mushroom identified by Japanese scientists several decades ago to have the greatest ability to increase natural killer cell activity. Its molecular weight has been reduced using a patented enzymatic process to improve its absorption and clinical efficacy. Every batch of AHCC is subjected to DNA pattern testing to confirm its identity (in other words, to ensure it is genuine AHCC). These innovations make AHCC unique among medicinal mushrooms.

AHCC is available from multiple nutritional supplement companies, but it is important to steer clear of fake products using different names yet claiming similar benefits. Only genuine AHCC® has been clinically tested and found to help clear HPV.

Click to read the full study

Here is a list of genuine AHCC products.

AHCC® is a registered trademark of the Amino Up Company

A Note for Anal Cancer Survivors

Because this study was conducted on women with vaginal HPV infections, we reached out to Dr. Romesser, a radiation oncologist specializing in anal cancer at Memorial Sloan Kettering, to ask about anal cancer survivors and AHCC. No side effects from AHCC were reported in women with vaginal HPV in the study described above; however, there is some anecdotal indication that there may be mild side effects for anal cancer survivors. Dr. Romesser has noticed that some anal cancer survivors experience side effects like anal itching when they start taking AHCC. Therefore, he recommends that anal cancer patients who have recently had treatment, wait to take AHCC until all the side effects from treatment have subsided.  It also seems that for some anal cancer survivors, the side effects from taking AHCC go away after a few weeks. It might be worthwhile to continue taking AHCC for a few weeks despite any side effects in case the side effects subside.

Your Questions Answered About AHCC® and

Questions About Papillex

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What is Papillex^® ?

Papillex® is a clinically-researched, nutrient-rich supplement designed to support your immune system in response to the presence of viral factors like HPV. The key ingredients in Papillex® safely and effectively support the body’s natural ability to regulate genital warts, cervical dysplasia and other HPV-related conditions. Papillex® can help to support your immune system and restore your peace of mind.

What should I do in addition to taking Papillex^®?

In addition to taking Papillex®, consider supplementation with the medicinal mushroom AHCC^® (1-6 grams daily) and Vitamin C (1-2 grams daily). Eat a diet high in fruits and vegetables and minimize the ingestion of refined carbohydrates, sugar, animal products and saturated fats that impair immunity and contribute to inflammation in the body. Do not smoke, as smokers exhibit a 200-300% higher incidence of cervical dysplasia. Strengthen your immune system with optimal sleep (7-8 hours nightly), exercise and stress reduction.

Can I take Papillex^® with my other supplements or medications?

There are no known interactions with Papillex® and any natural supplements or medications. If you are taking other medications, we advise you to consult with your healthcare practitioner before taking this product.

Is it safe to take Papillex^® even if I have not been diagnosed with HPV?

Yes, Papillex® is safe for daily preventative use.

Is there anyone who should not take Papillex^® ?

If you have foreign organs and tissues, including bone marrow and corneal transplants, it is cautioned not to take any immune-regulating nutritional supplements. Therefore, Papillex® is NOT recommended for transplant patients. People with synthetic replacement/reconstruction will not be affected, e.g. hip, knee, breast, or pacemaker. People with autoimmune diseases, such as Crohn’s disease, multiple sclerosis or systemic lupus erythematosus shouldn’t use Papillex® unless recommended by a qualified healthcare practitioner. We recommend consulting with your health care practitioner before beginning any natural health care regime.

Are there any cautions associated with taking Papillex^® ?

If you are pregnant, nursing, a diabetic, an organ transplant recipient or have multiple sclerosis, do not use Papillex® unless you are under the direct supervision of a health care professional.

How long before I might expect to see some results?

As with many natural supplements, it can take a period of time before you notice an improvement in your health. Although some people notice a difference sooner, we suggest that you take Papillex® for at least 90 days before evaluating whether it is effective for you.

Does Papillex^® have any side effects?

We do not have any reports of side effects. This product has been safely used by clients for more than a decade.

How should I take Papillex^®?

Take two capsules daily or twice daily. Papillex® can be taken with or without food. For those with difficulty swallowing, the capsule can be opened and the contents mixed with apple sauce or fruit juice.

Are there any natural therapies for severe dysplasia?

For severe dysplasia, in addition to supplementation, cervical escharotic therapy is a natural option. This procedure involves the application of bromelain directly to the cervix, followed by a solution of zinc chloride and Sanguinaria canadensis (bloodroot). Sanguinaria has a history of use as a regulatory herb and may alter neovascularization, the process whereby a growing tumor increases its blood supply. Washing the cervix with a calendula solution and applying an herbal compound of thuja, echinacea, goldenseal, and ligusticum finishes the escharotic procedure. This procedure can be done by a naturopathic physician specialized in this treatment.

What is your Shipping Policy?

Orders arrive to US customers within 2-7 business days via USPS Priority Mail. All orders placed by 1:00pm Eastern Time (10:00am Pacific Time) Monday through Friday, are shipped that same day.

We provide low, flat-rate shipping regardless of the number of items ordered or weight of your package, and when necessary will upgrade to ensure you receive your order FAST!

Placing an International Order

• Please allow up to 2-4 weeks for delivery.
• For customers in the UK: Please note that shipments with a merchandise total exceeding 18 pounds sterling may be held in customs until you, the ordering party, pay the national VAT (value added tax). The VAT is usually paid when the postal carrier delivers your mail. However, the British Postal Service might hold shipments with a value over 18 pounds without notifying you, the customer.
• If the package is held by customs for any reason and the package is not returned to Papillex^®, we regret we cannot issue a refund. If we receive a package back after it has been held and the products are in sealed, unused condition, we will credit you the product cost (shipping charges still apply).
• Payment of shipping duties and customs fees varies by country and is the responsibility of the purchaser.

What is your Return Policy?

Papillex® Satisfaction Guarantee: You can return items purchased directly from us for any reason within 30 days of purchase. You will receive a full refund for unopened items in the original form of payment via Paypal. Shipping and handling fees are non-refundable. Please package the product carefully. We must receive the return within the 30-day period. Papillex^® reserves the right, at its sole discretion, to reject a return that does not comply with these conditions. Please send us an email to inform us of the refund request, then ship your purchase and receipt, with a note requesting a refund, to our Returns Department:

Shipmonk – Returns / Papillex^® Inc. 
285 Centerpoint Blvd
Pittston, PA 18640-6136
Email: [email protected]

Questions About AHCC

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What is AHCC^® ?

AHCC^® is a nutritional supplement derived from the root-like hairs of the shiitake mushroom, also known as Lentinula edodes. The compound modulates the immune system by stimulating the production of white blood cells.

AHCC^® has been used for centuries in traditional medicine. Over the past 20 years, the compound has undergone extensive scientific research with more than 30 clinical trials supporting its use in response to viral infections and cancers by supporting the immune system.

AHCC^® is extracted through an extensive and controlled patented manufacturing process by Amino Up Chemical Co. Ltd. The final product is commonly taken in capsule or powdered form.

What are the active components of AHCC^® ?

AHCC^® contains polysaccharides called alpha and beta-glucans. Polysaccharides are found in many plants and fungal species and have been found to have many healing properties. Beta-glucans are found in many medicinal mushrooms and improve gut immunity.

Alpha-glucans also interact with the immune system but since they are smaller molecules that beta-glucans they are easily absorbed and have a direct impact on the immune system. This unique feature allows for a more efficient immune response which makes AHCC^® an effective immune modulator, compared to other mushrooms.

Are there any side effects of taking AHCC^® ?

Minimal side effects of nausea, muscle cramps, and diarrhea have been reported in some individuals but generally, AHCC^® is well tolerated.

Can I take AHCC^® with other medications or supplements?

AHCC^® is safe to supplement alongside most medications and supplements besides those metabolized by the CYP450 2D6 pathway. We recommend consulting a physician before using AHCC^® if you are taking any medications, both prescription, OTC, and any supplements.

How much AHCC^® do I need to take?

Generally, a dose of 1-3 grams daily is recommended for general immune support in healthy individuals. Higher dosages of 3-6g daily may be taken to support the immune system in response to more specific conditions. We recommend consulting a physician for guidance before dosing above 1-3 grams.

When and how should I take AHCC^® ?

Clinical studies recommend supplementing AHCC^® in two doses daily on an empty stomach. The first dose is taken in the morning and the second dose at night. If swallowing or taking supplements is a challenge, AHCC^® may also be taken with food.

How can I tell if AHCC^® is working?

It can take time before you notice an improvement in your health when taking AHCC^®. We recommend supplementing daily for at least three months for the compound to take effect.

It can be helpful to record general health indicators when starting a nutritional supplement. Evaluate symptoms like energy levels, sick days per month, mood, digestion, etc.on a scale of 1-10 in a journal to help better monitor your improvement over time.

Questions About SIMPLIX™

How do I take Simplix™?

For active cases, we recommend 2 capsules twice per day until the outbreak clears up. 

For maintenance, we recommend 2 capsules once per day.

Note: sores may still be contagious up to seven days after they heal, so continue use for 1 week after physical signs disappear.

How long do I have to take Simplix™ to see results?

That depends on how frequently you experience HSV outbreaks. You may notice that you are having fewer outbreaks, and/or that they are milder and/or shorter in duration after using Simplix™ for a few months. 

If you only experience outbreaks once or twice a year, you may not know how Simplix™ will impact your outbreaks for a year. You may, however, notice other side benefits such as better immune function (ex: fewer colds and flus) and an improved stress response.

Are there any side effects with Simplix™?

Numerous studies have shown that the ingredients in Simplix™ have excellent safety profiles and are generally well tolerated. Some people may experience mild intestinal side effects such as nausea, cramping, or diarrhea.

As with any supplement or medication, allergic reactions are possible.

Who can take Simplix™?

Simplix™ is recommended for individuals over the age of 18

Who shouldn’t take Simplix™?

Individuals who are diabetic or have trouble maintaining blood sugar should not take Simplix™, as well as those who have liver disease, high blood pressure, heart disease, kidney disease, hormone sensitive cancers, hypotonia, or hypokalemia. Pregnant or breastfeeding women also should not take Simplix™.

Always consult with your doctor about taking supplements if you have any health conditions.

Can I take Simplix™ together with my prescription HSV medication?

While we believe that Simplix™ is not likely to interact with antiviral medications, we always recommend consulting with your doctor about taking Simplix™ if you are on any medication.

Can I take Simplix™ with other medications?

We always recommend speaking to your doctor about taking Simplix™ if you are on any medication. 

Can I take Simplix™ for other viral infections?

Yes. While the Simplix™ formulation was designed to have HSV regulatory benefits as the most prominent action, most of the ingredients also have general effects that could be beneficial for other viral issues.  

Where Can I Buy Simplix™?

Shop Simplix™ on our website with free shipping and discreet packaging. Or buy on Amazon: Click here for Canada. Click here for the US. 

How do I store Simplix™ Supplements

When storing, avoid excessive light, heat, or moisture. 

What is your Shipping Policy?

Orders arrive to US customers within 2-7 business days via USPS Priority Mail. All orders placed by 1:00pm Eastern Time (10:00am Pacific Time) Monday through Friday, are shipped that same day.

We provide low, flat-rate shipping regardless of the number of items ordered or weight of your package, and when necessary will upgrade to ensure you receive your order FAST!

Placing an International Order

• Please allow up to 2-4 weeks for delivery.
• For customers in the UK: Please note that shipments with a merchandise total exceeding 18 pounds sterling may be held in customs until you, the ordering party, pay the national VAT (value added tax). The VAT is usually paid when the postal carrier delivers your mail. However, the British Postal Service might hold shipments with a value over 18 pounds without notifying you, the customer.
• If the package is held by customs for any reason and the package is not returned to Simplix™, we regret we cannot issue a refund. If we receive a package back after it has been held and the products are in sealed, unused condition, we will credit you the product cost (shipping charges still apply).
• Payment of shipping duties and customs fees varies by country and is the responsibility of the purchaser.

What is your Return Policy?

Simplix™ Satisfaction Guarantee: You can return items purchased directly from us for any reason within 30 days of purchase. You will receive a full refund for unopened items in the original form of payment via Paypal. Shipping and handling fees are non-refundable. Please package the product carefully. We must receive the return within the 30-day period. Simplix™ reserves the right, at its sole discretion, to reject a return that does not comply with these conditions. Please send us an email to inform us of the refund request, then ship your purchase and receipt, with a note requesting a refund, to our Returns Department:

Shipmonk – Returns / Papillex Inc.  
285 Centerpoint Blvd
Pittston, PA 18640-6136
Email: [email protected]

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Papillex^® Inc.
941 E Lovejoy Street, Buffalo NY, 14206-10032
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AHCC Immune Support 500 mg 60 capsules

AHCC Immune Support / AHCC Immune Support 500 mg 60 capsules Ltd. (Sapporo) and Dr. Toshihiko Okamoto, member of the Faculty of Pharmacy, University of Tokyo in 1989. The process looks like this. A hybrid of shiitake, maetake and reishi is grown in a liquid nutrient medium based on brown rice. The shell of rice grains is rich in cellulose. Shiitake, maetake and reishi mushrooms lack chlorophyll and, unlike plants, are not capable of photosynthesis. So they eat like animals. They release enzymes into the environment, digest the nutrients there, and absorb them. During this process, rice cellulose, a high molecular weight polysaccharide, is broken down by fungal enzymes (carbohydrases) into small fragments – oligosaccharides. After a certain period of cultivation, the mushroom material with fermentation products is centrifuged, concentrated and subjected to dry freezing. Then it is packaged in capsules.

Shiitake (Shiitake – Lentinula edodes). It has been shown that eating 9 g of dry shiitake mushroom (equivalent to 90 g fresh) for 7 days lowered cholesterol levels in 40 older adults by 15% and in 420 young women by 15%. In 1969, researchers at the National Research Center in Tokyo isolated the polysaccharide lentinan from shiitake. To date, it is a well-known pharmacological preparation for intravenous administration in disorders of the immune system and oncological diseases. In the 1970s, Japan mastered the technology for obtaining LEM (Lentinula edodes myucelium) – an extract from shiitake mycelium. In the 80s, in 16 clinics in Japan, 40 patients with hepatitis B received 6 g of LEM daily for 4 months. All patients experienced significant relief, and in 15 the virus was completely inactivated. There is evidence that LEM is highly effective in HIV infection. In its ability to curb the development of AIDS, it surpassed such a well-known drug as AZT (laboratory studies with T4 helper cells).

Maetaki (Maitake – Grifola frondosa) In Japan, Maetaki is called the dancing mushroom because of its bizarre shape. It is well known for its ability to lower blood pressure and normalize blood lipids. But the true fame of maitake brought anti-cancer properties. Two polysaccharides were identified in its composition: grifolan and D-fraction. Grifolan activates macrophages. D-fraction enhances cellular immune responses. One study in which 165 cancer patients took part showed the effectiveness of the D-fraction, especially in leukemia and gastric cancer. Another high molecular weight maitake polysaccharide, X-fraction, has been shown in laboratory studies in mice to normalize blood sugar levels and insulin sensitivity in type II diabetes.

Reishi (Reishi – Ganoderma lucidum) For 4,000 years, Reishi mushroom has been used by the Chinese and later by the Japanese for liver disease, high blood pressure and joint inflammation. Modern laboratory and clinical studies have revealed the anti-inflammatory, antiviral, antimicrobial, antiallergic and antitumor properties of reishi mushroom. Reishi mushroom has a special therapeutic value in diseases of the upper respiratory tract. In one study, 2,000 Chinese people with chronic bronchitis took reishi syrup for 2 weeks. 60-90% of them noted a pronounced improvement in well-being. But the almost mystical property of Reishi is its ability to increase the strength of the spirit, increase a positive emotional mood.

Functional actions :
• Increases immunity. It activates T-helpers, secretes interleukin-12, which directs the development of T-helpers to provide the cellular link of immunity, and also dramatically increases the activity of natural killers – the main fighters against tumor cells.
• Secretes other cytokines: interleukins 1, 6, tumor necrosis factor-alpha, which, enhancing inflammatory reactions and integrating the protective reactions of the whole body, begin to secrete interleukin-2, which leads to the reproduction and activation of T-helpers, as well as T-killers , macrophages and natural killers, which increase their cytotoxicity in relation to tumors.
• Acts on macrophages with interferon-gamma and tumor necrosis factor-alpha, as a result of which macrophages acquire antitumor properties (the ability to process tumor antigens, release of tumor necrosis factors-alpha and beta, direct destruction of tumor cells, etc. ), with the help of interleukin -3 and colony-stimulating factors enhances the processes of hematopoiesis. Low molecular weight components of AHCC have a stimulating effect on T-helpers. Activated natural killers sharply increase their antitumor effect and secrete interferon – gamma, which activates macrophages.
• Has a direct antitumor effect by inhibiting tumor growth and neutralizing tumor factors that suppress the immune system (such as transforming growth factor-beta). The onset of the tumor process occurs when the immune system is weakened. Most tumors, due to the fact that they originate from the body’s own tissues, have weak immunogenicity. Malignant growth is always accompanied by a significant weakening of immune functions. The number of type 1 T-helpers, which are the organizers of the immune response from the cellular link of immunity, is especially sharply reduced. Namely, T-killers, natural killers, K-cells, macrophages play a major role in antitumor immunity. In addition, the immune system is drastically weakened after surgery, radiotherapy and chemotherapy.
• It has a pronounced protective effect of the liver (which is important in the treatment of hepatitis), enhances the overall ability of the body to detoxify, and also provides it with various biomolecules, the synthesis of which occurs in the liver.
• It has a pronounced antioxidant effect, which is important in the complex therapy of oncological diseases, rehabilitation after radio- and chemotherapy.
• Protecting the immune system from the damaging effects of corticosteroids.

Indications for use :
• Weakened immunity.
• Chronic fatigue syndrome.
• Benign and malignant neoplasms.
• Immunodeficiency (AIDS).
• Hepatitis A, B and C.
• Diabetes.
• Skin viral diseases.
• Atopic dermatitis.
• Urogenital infections.
• Rheumatoid arthritis.

How to use and doses recommended by the Association for the Study of AHCC.
To strengthen the immune system:
2 capsules 3 times a day for 30 minutes. before meals. Children: 1 capsule 1 time per day. Children’s dose = (adult dose / 75) x child’s weight.
In the treatment of cancer, prevention of side effects of chemotherapy: 6-12 capsules per day.
Course duration: 2 weeks to improve the quality of life (especially after radio- and chemotherapy). 3 months to reassess the severity of cancer.
For greater effect, take with Beta 1,3/1,6-D-Glucan and Immune Renu.

Contraindications :
Individual intolerance, blood diseases.
It is not recommended to use ANCC during chemotherapy with Adriamycin (Doxorubicin), when using the antiemetic Ondansetron, and when treating with Tamoxifen.

Storage conditions :
Store in a dry, cool place out of the reach of children, t° not higher than +25°С.

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Japanese AHCC complex

The use of high molecular weight polysaccharides for the treatment of cancer was first developed by the Japanese company Amino UP Chemical Co. Ltd. A mixture based on shiitake, maetake and reishi mushrooms is a natural AHCC complex.

Revolutionary formulation works with polysaccharides, amino acids and minerals. It is prescribed for pathologies of internal organs, oncological diseases.

AHCC preparation: composition and features

1. Shiitake. Components are used at increased risks of cancer and for the treatment of cancer patients. Mycelium is relevant for immunodeficiency syndrome, hepatitis. Penetrating into the cells, shiitake curb the progression of the disease, reducing the manifestation of symptoms.

2. Maetaki (dancing mushroom). Immunomodulating properties prevent the degeneration of benign formations. Also, the ANSS ingredient normalizes blood pressure, prevents the development of hypertension, and maintains blood sugar levels. By activating macrophages, they stimulate the reaction of cell defense.

3. Reishi. It is relevant for oncological pathologies of the esophagus, liver, pancreas, lungs, bone tissue and brain. It is used in medicine for the treatment of joints, respiratory problems.

Indications for the use of AHCC

According to the opinions of specialists and patients, AHCC is needed as an additional support in diagnosing:

• malignant and benign neoplasms;

• immunodeficiency virus, immunocompromised;

• type 2 diabetes;

• liver diseases, including hepatitis B and C;

• skin diseases, herpes and other viral infections;

• irritability, chronic fatigue syndrome.

Properties Additive AHCC

The effectiveness of the drug has been proven by laboratory tests. The dose for prevention is 1000-300 mg of the active substance. When using a cancer support supplement, the dosage is increased to 3000-6000 mg. Benefits:

• Polysaccharides have a beneficial effect on the links of cellular immunity, activate T-helpers when the components are absorbed by macrophages;

• Stimulate the natural reproduction of T-helpers in the body;

• ANSS has a direct antitumor effect, inhibiting and reducing the growth of neoplasms that suppress the effective functioning of the immune system;

• Promotes the release of interferon-gamma, necessary for the activation of macrophages;

• Protects the liver from the negative effects of drugs, chemotherapy and radiotherapy;

• Performs the task of a powerful antioxidant during the rehabilitation period.