How long does mucinex dm last. Mucinex DM Maximum Strength: Uses, Dosage, Side Effects & Duration

12.02.197328.08.2021 by alexxlab

How long does Mucinex DM Maximum Strength last. What are the active ingredients in Mucinex DM Maximum Strength. What are the uses and warnings for Mucinex DM Maximum Strength. How should Mucinex DM Maximum Strength be taken.

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What is Mucinex DM Maximum Strength?

Mucinex DM Maximum Strength is an over-the-counter medication used to relieve cough and chest congestion. It contains two active ingredients:

Guaifenesin (1200 mg) – an expectorant that helps loosen and thin mucus in the airways
Dextromethorphan HBr (60 mg) – a cough suppressant that reduces the urge to cough

This extended-release formulation is designed to provide relief for up to 12 hours per dose. The bi-layer tablets have a white and yellow appearance and are oval-shaped.

What are the uses of Mucinex DM Maximum Strength?

Mucinex DM Maximum Strength is indicated for the following uses:

Loosening phlegm (mucus) and thinning bronchial secretions to clear airways
Temporarily relieving cough due to minor throat and bronchial irritation from colds or inhaled irritants
Reducing the intensity and frequency of coughing
Suppressing cough to help with sleep

The guaifenesin component acts as an expectorant to make coughs more productive, while the dextromethorphan provides cough suppression.

How should Mucinex DM Maximum Strength be taken?

The recommended dosage instructions for Mucinex DM Maximum Strength are:

Adults and children 12 years and older: Take 1 tablet every 12 hours, not to exceed 2 tablets in 24 hours
Children under 12 years: Do not use
Swallow tablets whole with a full glass of water – do not crush, chew, or break
Can be taken without regard to food
Do not exceed the recommended dose

How quickly does Mucinex DM Maximum Strength work? The extended-release formulation is designed to start working relatively quickly and provide relief for up to 12 hours per dose. However, individual response times may vary.

What are the warnings and precautions for Mucinex DM Maximum Strength?

Important warnings and precautions to be aware of include:

Do not use in children under 12 years of age
Do not use if taking monoamine oxidase inhibitors (MAOIs) or within 2 weeks of stopping an MAOI
Ask a doctor before use if you have a persistent/chronic cough or cough with excessive mucus
Stop use and consult a doctor if cough lasts more than 7 days, returns, or occurs with fever, rash, or headache
Ask a healthcare professional before use if pregnant or breastfeeding
Keep out of reach of children
Do not use more than directed

Is it safe to drive while taking Mucinex DM Maximum Strength? While drowsiness is not a common side effect, it’s best to see how the medication affects you before driving or operating machinery.

What are the potential side effects of Mucinex DM Maximum Strength?

Common side effects may include:

Nausea
Stomach discomfort
Headache
Dizziness

Serious side effects are rare but may include:

Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Persistent nausea/vomiting
Irregular heartbeat
Severe dizziness

Can Mucinex DM Maximum Strength cause drowsiness? While not commonly reported, some individuals may experience drowsiness. It’s best to see how the medication affects you before driving or operating machinery.

How long does Mucinex DM Maximum Strength last?

Mucinex DM Maximum Strength is formulated to provide relief for up to 12 hours per dose. The extended-release tablets are designed to gradually release the active ingredients over this period. However, individual responses may vary based on factors like:

Severity of symptoms
Individual metabolism
Other medications being taken
Food and fluid intake

When does Mucinex DM Maximum Strength start working? The medication typically begins to take effect within 30-60 minutes after ingestion. However, it may take a few doses to experience the full benefits, especially for loosening and thinning mucus.

What are the inactive ingredients in Mucinex DM Maximum Strength?

The inactive ingredients in Mucinex DM Maximum Strength include:

Carbomer 934P, NF
D&C yellow #10 aluminum lake
Hypromellose, USP
Magnesium stearate, NF
Microcrystalline cellulose, NF
Sodium starch glycolate, NF

These ingredients help form the tablet, control its release properties, and give it its characteristic appearance.

How does Mucinex DM Maximum Strength compare to other cough medications?

Mucinex DM Maximum Strength differs from other cough medications in several ways:

Combination formula: It contains both an expectorant (guaifenesin) and a cough suppressant (dextromethorphan), addressing multiple symptoms.
Extended-release: The 12-hour formulation provides longer-lasting relief compared to standard formulations.
Higher strength: The “Maximum Strength” designation indicates higher doses of active ingredients compared to regular strength versions.
Non-drowsy: Unlike some cough medications containing antihistamines, Mucinex DM Maximum Strength is not typically associated with drowsiness.

How does Mucinex DM Maximum Strength compare to Mucinex DM? The main difference is the strength of active ingredients. Maximum Strength contains higher doses of both guaifenesin (1200 mg vs 600 mg) and dextromethorphan (60 mg vs 30 mg) compared to regular Mucinex DM.

Comparing Mucinex DM Maximum Strength to Other Cough Medications

Medication	Active Ingredients	Duration	Drowsiness
Mucinex DM Maximum Strength	Guaifenesin 1200 mg, Dextromethorphan 60 mg	12 hours	Non-drowsy
Regular Mucinex DM	Guaifenesin 600 mg, Dextromethorphan 30 mg	12 hours	Non-drowsy
Robitussin DM	Guaifenesin 200 mg, Dextromethorphan 10 mg per 5 mL	4-6 hours	Non-drowsy
NyQuil	Acetaminophen, Dextromethorphan, Doxylamine	6-8 hours	Drowsy

Is Mucinex DM Maximum Strength more effective than other cough medications? While it may provide longer-lasting relief due to its extended-release formula and higher strength, effectiveness can vary between individuals. It’s best to consult with a healthcare provider to determine the most appropriate medication for your specific symptoms.

What are the storage recommendations for Mucinex DM Maximum Strength?

To ensure the effectiveness and safety of Mucinex DM Maximum Strength, follow these storage recommendations:

Store at room temperature between 20-25°C (68-77°F)
Keep away from excessive heat and moisture
Do not use if the carton is open or if the printed seal on the blister pack is broken or missing
Keep out of reach of children

How long can Mucinex DM Maximum Strength be stored? Check the expiration date on the package and do not use after this date. Generally, when stored properly, the medication should remain effective until the expiration date.

Tips for Proper Storage and Use

Keep the medication in its original packaging to protect from light and moisture
Do not transfer to other containers, as this may lead to confusion or accidental misuse
Dispose of expired medication properly – many pharmacies offer medication disposal services
Always read the label before use to ensure you’re taking the correct dose

By following these storage and usage guidelines, you can help maintain the effectiveness and safety of Mucinex DM Maximum Strength.

Mucinex DM Maximum Strength – FDA prescribing information, side effects and uses

Professionals
FDA PI
Mucinex DM Maximum Strength

Generic name: guaifenesin and dextromethorphan hydrobromide
Dosage form: tablet, extended release
Drug class: Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Nov 23, 2020.

Drug Facts

Active ingredients (in each extended-release bi-layer tablet)	Purpose
Dextromethorphan HBr 60 mg	Cough suppressant
Guaifenesin 1200 mg	Expectorant

Uses

helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive
temporarily relieves:
- cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants
- the intensity of coughing
- the impulse to cough to help you get to sleep

Warnings

Do not use

for children under 12 years of age
if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

Ask a doctor before use if you have

persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema
cough accompanied by too much phlegm (mucus)

When using this product

do not use more than directed

Stop use and ask a doctor if

cough lasts more than 7 days, comes back, or occurs with fever, rash, or persistent headache. These could be signs of a serious illness.

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

do not crush, chew, or break tablet
take with a full glass of water
this product can be administered without regard for timing of meals
adults and children 12 years and older: 1 tablet every 12 hours; not more than 2 tablets in 24 hours
children under 12 years of age: do not use

Other information

tamper evident: do not use if carton is open or if printed seal on blister is broken or missing
store at 20-25°C (68-77°F)

Inactive ingredients

carbomer 934P, NF; D&C yellow #10 aluminum lake; hypromellose, USP; magnesium stearate, NF; microcrystalline cellulose, NF; sodium starch glycolate, NF

Distributed by:
Reckitt Benckiser Inc.
Parsippany, NJ 07054-0224
©RBI 2009

PRINCIPAL DISPLAY PANEL – 1200 mg Carton

MAXIMUM STRENGTH

NDC 63824-072-35

Mucinex®DM

1200 mg guaifenesin & 60 mg dextromethorphan HBr
extended-release bi-layer tablets

EXPECTORANT & COUGH SUPPRESSANT

12 HOUR

NEW LOOK-
SAME RELIEF

Thins And Loosens Mucus

Controls Cough

14 EXTENDED-RELEASE BI-LAYER TABLETS

MUCINEX DM MAXIMUM STRENGTH
guaifenesin and dextromethorphan hydrobromide tablet, extended release

Product Information
Product Type	HUMAN OTC DRUG	Item Code (Source)	NDC:63824-072
Route of Administration	ORAL	DEA Schedule

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
Guaifenesin (Guaifenesin)	Guaifenesin	1200 mg
Dextromethorphan Hydrobromide (Dextromethorphan)	Dextromethorphan Hydrobromide	60 mg

Product Characteristics
Color	WHITE (yellow and white)	Score	no score
Shape	OVAL	Size	22mm
Flavor		Imprint Code	Mucinex;1200
Contains

Packaging
#	Item Code	Package Description
1	NDC:63824-072-35	2 BLISTER PACK (BLISTER PACK) in 1 CARTON
1		7 TABLET, EXTENDED RELEASE (TABLET) in 1 BLISTER PACK
2	NDC:63824-072-36	4 BLISTER PACK (BLISTER PACK) in 1 CARTON
2		7 TABLET, EXTENDED RELEASE (TABLET) in 1 BLISTER PACK
3	NDC:63824-072-39	1 BOTTLE (BOTTLE) in 1 CARTON
3		38 TABLET, EXTENDED RELEASE (TABLET) in 1 BOTTLE
4	NDC:63824-072-45	1 BOTTLE (BOTTLE) in 1 CARTON
4		44 TABLET, EXTENDED RELEASE (TABLET) in 1 BOTTLE

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NDA	NDA021620	03/31/2009

Labeler – Reckitt Benckiser, Inc.

(094405024)

Reckitt Benckiser, Inc.

More about Mucinex DM Maximum Strength (dextromethorphan / guaifenesin)

Consumer resources

Professional resources

Other brands: Tussin DM, Biocotron, Guiadrine DX, HT Tuss DM

Other Formulations

Related treatment guides

Medical Disclaimer

Does mucinex maximum strength make you drowsy? – AnswersToAll

Does mucinex maximum strength make you drowsy?

Mucinex maximum strength Expectorant is easy to swallow. It works immediately. You will feel better right away. There are no drowsy side effects.

Is Mucinex DM drowsy or non drowsy?

When you need some help shaking that chest congestion, Mucinex and Mucinex DM are two over-the-counter drugs that might help….Side effects.

Common side effects	Mucinex	Mucinex DM
drowsiness	✓	✓
headache	✓	✓
nausea, vomiting, or both	✓	✓
stomach pain	✓	✓

How long does mucinex last in your system?

How long does Mucinex DM stay in your system? Mucinex DM consists of an outer tablet that contains immediate-release versions of its two active ingredients guaifenesin and dextromethorphan. The inner tablet slowly releases guaifenesin over the next 12 hours. Cough relief should last about 12 hours.

Which mucinex should I take for sinus congestion?

Mucinex D (Guaifenesin / Pseudoephedrine) is a combination medicine that relieves multiple cold symptoms. It’s good to use if you have sinus and chest congestion. Helps loosen the mucus in your airways so that you can cough it up more easily. Works well to clear nasal congestion and help you breathe better.

Can I take mucinex with my albuterol?

Interactions between your drugs No interactions were found between albuterol and Mucinex DM.

How many days should you take mucinex?

Do not take this medication for more than 7 days unless your doctor tells you to do so. Tell your doctor if your condition lasts longer than 7 days.

Should I take mucinex at night?

You can take Mucinex and NyQuil together safely if you follow the recommended dosage for each drug. However, taking Mucinex at night with NyQuil might actually keep you from falling asleep. Mucinex will loosen your mucus, which can cause you to wake up to cough.

Can mucinex be taken every day?

This medication can typically be taken with or without food. A typical adult dose of Mucinex is 1 to 2 600mg tablets every 12 hours, or 1 maximum strength tablet (1200mg) every 12 hours.

How much guaifenesin can you have in a day?

Doses of guaifenesin are usually taken 4 hourly as required, with a maximum of 4 doses in any 24 hour period. Do not take more than the amount recommended on the packaging of the medicine you have purchased. The maximum recommended adult dose of guaifenesin is a total of 2400mg per day.

Is it safe to take guaifenesin everyday?

This single patient case study suggests that daily guaifenesin may have contributed to rapid improvement of symptoms and quality-of-life in a patient with CRS and that these effects are sustainable with long-term use.

How Long Does DXM Stay in Your System? (Blood, Urine & More)

DXM usually stays in the body for about a day. It can be detectable on most urine tests for one to two days, but it may return a false positive for PCP.

How Long Can DXM Be Detected In The Body?

Dextromethorphan (DXM) is not a drug most employers and organizations test for. A 2010 study published by Laboratory Medicine said that testing for the drug often resulted in false positives for PCP. Based on its half-life, it is estimated that a healthy individual can get rid of DXM within 11 to 22 hours.

To get rid of DXM, the liver converts it into a metabolite called dextrorphan. This chemical has a half-life of about 1.7 to 5.4 hours. It may take between nine to 29 hours to fully get rid of dextrorphan after a person’s last dose.

Below are estimates for how long blood tests of various types can detect DXM:

Urine

It may be possible to detect DXM one to two days after use, but standard tests may detect it as PCP.

Blood

The National Library of Medicine says that DXM is at its peak in a person’s body for up to 2. 5 hours after taking it. Blood tests can probably detect DXM anywhere from three to 24 hours after use.

Saliva

Saliva tests do not typically look for DXM because it is such a common over-the-counter medication. More research needs to be done on how long DXM may be detectable in saliva. For now, the window for detection with this test is limited.

Hair follicles

DXM may be present in a person’s hair follicles for up to 90 days after a person’s last do

DXM Abuse

The majority of Americans have taken over-the-counter medication such as DayQuil, TheraFlu, or Dimetapp to soothe a cold or cough. These medications are seen as innocent and relatively safe when taken as indicated. Cough and cold syrups and some tablets popularly sold in pharmacies and grocery stores across the country often contain dextromethorphan (DXM) as part of their main ingredients.

DXM is a popular drug of abuse among teenagers because it is accessible and does not raise suspicion.

Still, authorities are catching on to the abuse of DXM. Consumer Reports says that concerns about DXM abuse have existed since the 1960s. Some drug tests can now test for DXM, and awareness of DXM misuse is growing.

Abstaining from a drug is the only way to truly pass a drug test. Despite the consequences, some people may still take high doses of DXM and want to know how long it stays in their bodies.

Basic Facts About DXM

More than 100 over-the-counter products contain DXM, as mentioned in Consumer Reports. In addition, drugs that have DXM as an ingredient may contain other ingredients meant to soothe a cough or cold, such as pain relievers, antihistamines, and decongestants.

The most popular cold and cough medicines seem to be syrups, but they can also be sold as capsules, lozenges, or tablets. DXM is an ingredient in cold medicines of this kind as well.

Some people may need as much as 120 mg (milligrams) of DXM to treat their cold or cough, but far less than this is effective in most people. People have also been known to use far more than this for recreational reasons.

DXM can be detected in some drug tests, and Laboratory Medicine says it may even be the cause of false positives for PCP on some drug tests. The National Library of Medicine says the half-life of is DXM is between two to four hours in healthy people.

How Half-Life Influences How Long DXM Remains In Your System

A half-life refers to how long it takes to get half of the medication out of one’s bloodstream. For example, if a person takes DXM, it will take two to four hours for half of what they took to exit their body.

Genes, height, weight, and other factors play a role in metabolizing a drug and flushing out the drug. Over-the-counter medicines not only direct how much should be taken to relieve cold and cough symptoms, but they also give instructions about how often they should be taken.

The Mayo Clinic says people who take DXM for cough or cold should seek medical attention if their symptoms do not go away after seven days.

These directions are meant to avoid accumulating drugs in the body and taxing the liver, which metabolizes most drugs.

Detoxing From DXM

Properly detoxing from DXM could take anywhere from a few hours to a few days, but more research is needed to give an exact timetable. A study published in the Psychopharmacology Journal in 2017 documents detox processes that take at least a week.

Detoxing from long-term use of DXM, or large amounts of DXM can also cause many withdrawal symptoms including:

Anxiety
Insomnia
Increased sweating

The results of the study showed that people who have misused DXM for a long time may be better off detoxing under medical supervision.

Those who use DXM but are not addicted to it may simply be concerned about passing a drug test for a potential employer or legal reasons.

Common ways people prepare to pass a drug test, as mentioned on Vice, are:

Drinking a lot of water
Taking over-the-counter detoxifiers
Engaging in vigorous exercise

Keep in mind that some of these methods are self-reported. Vice mentions that the drug testing industry is also innovative and keeps up with trends. They may modify their methods at any time to be more accurate.

How Does Mucinex Work?

You might not realize it, but right now, your body contains tons of mucus; it lines your mouth, nose, throat, sinuses, lungs, and digestive tracts at all times. While we tend to think of mucus as being gross and bothersome, it actually is responsible for several important jobs in our bodies, including protecting us from disease and germs by acting as a barrier, defending our bodies with antibodies and enzymes, and lubricating the sensitive hairs and cells that line our respiratory tract. Despite the fact that mucus is a part of our everyday lives, we never think about it until we have too much of it. If you’ve ever had a hacking cough, sore throat, and chest congestion, you know how frustrating it is to feel like you’re constantly coughing but still have stuff floating around in your lungs. With approximately half of all common cold associated with a cough, this is a common issue faced by millions of people each year. When you have an unproductive cough that you can’t get rid of, the one thing you want most – to get the excess mucus out of our lungs – is the one thing you can’t seem to do. Like many Americans, you may have tried a medication called Mucinex, which is designed to help you get the gunk out of your lungs and get your life back together.

Mucinex Overview

Thanks to its popular commercials featuring grumpy germs dressed in suits and ties, you’re likely familiar with Mucinex, at least in its over-the-counter form designed to work on coughs. What you might not know is that Mucinex is offered both over the counter and at prescription drug strength, and it comes in many different forms designed to address a variety of symptoms that often occur with a cough. Sold under the generic name guaifenesin, Mucinex is an expectorant that helps to loosen and thin congestion in your chest and throat. When mucus is thick and sticking stubbornly to the walls of your lungs and throat, it’s difficult to cough it up, so Mucinex works by loosening and thinning the mucus in your chest. Mucinex can be purchased as a cough expectorant only, as a cough expectorant combined with a decongestant (Mucinex D), and as a cough expectorant combined with antihistamines, cough suppressants, and decongestants (Mucinex DM). Mucinex also sells products that help control cold and flu and sinus issues as well.

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The generic version of Mucinex, guaifenesin, is sold under many brand names, including: Actifed CC Chesty Cough, Benadryl Chesty Forte, Bronchoril, G Bid, GG-Cen, Ganidin NR, Guaiatussin, Guaifenesin LA, Guiatuss, Humavent LA, Humibid, Mucinex, Mucinex Maximum Strength, Max Strength, Mucinex for Kids, Mucus Relief, Congestion relief, Nirolex Chesty Cough, Organidin NR, Pneumomist, Robafen, Robitussin Chest Congestion, Sorbutuss, Strepsils Chesty Cough, Touro EX, Tussin, and Tussin Expectorant.

Conditions Treated

Because there are so many different types of Mucinex, which conditions the medication treats depend on which type is purchased. Mucinex is capable of treating a variety of ailments ranging from a stubborn cough and chest congestion to cold and flu or sinus pressure issues. No matter which type of Mucinex you choose, all of the associated products include ingredients that loosen and thin mucus in order to fight chest congestion.

Causes of Chest Congestion

We know that we need mucus to help our bodies function properly, but what determines how much mucus we produce? When our bodies are healthy, we produce the right amount of mucus needed to protect, moisten, and defend our airways. The mucus membranes that line your mouth, nose, throat, sinuses, and lungs are part of your body’s first defense against infection, keeping out dust, allergens, irritants, bacteria, and viruses. If we get an infection or are exposed to allergens or airborne pollution, our bodies can begin to produce too much mucus in an attempt to protect us from additional disease and irritation.
When our bodies start to produce too much mucus, this is when congestion occurs. Mucus works best when it is at the normal levels in our body, so if it becomes too thick, dense, or dry, it is unable to do its job. When this happens, bacteria can start to grow, causing an infection. It’s at this stage of an illness that you’ll start to notice symptoms like chest congestion, more colds, a wet or hacking cough, and extra congestion in the mornings. Coughing is the way our bodies try to break up the mucus in our lungs and expel it.

How Mucinex Works

If you’ve ever taken Mucinex and experienced the relief it can provide, you might find yourself wondering, “How does Mucinex work?” Like so many questions in life, the answer is “It depends.” The many different types of Mucinex all include different active ingredients designed to treat the specific symptoms targeted by a given formula. When it comes to chest congestion specifically, Mucinex works by thinning bronchial secretions and thinning the mucus in the air passages. As the medication starts to thin the mucus so it is easier to expel, it also works to loosen it. When mucus is thinner and looser your cough is more likely to be productive because your body is able to expel the mucus more easily. As you continue to cough, your body will be able to clear phlegm and mucus from the lungs and airways, helping to reduce your symptoms and allowing you to breathe more easily. Mucinex is not an antibiotic, so it does not treat the cause of congestion by killing bacteria that may be causing the infection. Mucinex also does not treat the cold or flu, does not prevent airborne pollution, and does not treat allergies. However, it can alleviate the most bothersome symptoms associated with chest congestion.

Cost

As already discussed, Mucinex comes in many different formulas to treat a wide range of symptoms. Mucinex can also be purchased in numerous forms, including an oral tablet, solution, syrup, packet, liquid, and nasal spray, depending on both the symptoms to be treated and the personal preference of the patient. Mucinex is relatively inexpensive even in its brand name forms, but for those looking to save more, the generic form of the drug, guaifenesin, may also be purchased. For comparison’s sake, the below chart demonstrates the costs of both Mucinex and guaifenesin in the form of 600 mg extended release oral tablets.

Approximate Costs of Mucinex and Guaifenesin

Mucinex
Guaifenesin

Per Pill
Pack of 20
Per Pill
Pack of 20
600 mg oral tablet
$0.98
$19.64
$0.57
$11.30

Benefits

The biggest benefit to using Mucinex is that the medication may help you feel better by thinning and loosening mucus in your body and leading to a productive cough. It’s also inexpensive and easy to find over the counter, so you won’t need to take a trip to a doctor’s office to get a prescription unless you need a stronger dose. Mucinex does not treat the root cause of chest congestion, so it will not kill bacteria that may be causing an infection, does not treat the cold or flu, does not prevent airborne pollution, and does not treat allergies, and it does not shorten the length of time that you’re likely to feel sick. It might help you breathe better, though!

Dosage

Due to the huge ranges in varieties, forms, and strengths of Mucinex, the best advice regarding dosage is generally to follow the directions listed on the package of the specific product that you buy. Regardless of the type of Mucinex you choose for your specific symptoms, make sure to drink plenty of water when taking it in order to stay hydrated and provide plenty of fluids for your body to help loosen the mucus. Extended release tablets should not be cut, crushed, or chewed and should be taken whole. Mucinex can be taken with or without food.

The standard adult dose for a cough depends on which type of formula is being used. The immediate release formula recommends a dose of 200 to 400 mg orally every 4 hours as needed, not to exceed 2400 mg per day. The sustained/extended release formula recommends an adult dose of 600 to 1200 mg every 12 hours, not to exceed 2400 mg/day.
Pediatric dosing recommendations are tricky. You must follow the package directions very closely when giving Mucinex to children, as the dose will vary based on their age and weight. In general, Mucinex should not be given to children under four years of age without speaking to a doctor or healthcare provider first. Using the immediate release formula, a dose for children between two and five years of age would be approximately 50 to 100 mg orally every 4 hours as needed, not to exceed 600 mg per day. Children between six and eleven years of age would take approximately 100 to 200 mg orally every 4 hours as needed, not to exceed 1200 mg per day. Children aged 12 years or older may take approximately 200 to 400 mg orally every 4 hours as needed, not to exceed 2400 mg per day.
The sustained/extended release formula comes with different recommendations for children. Using the sustained/extended release formula, children between two and five years of age may take approximately 300 mg orally every 12 hours, not to exceed 600 mg per day. Children between six and eleven years of age may take approximately 600 mg orally every 12 hours, not to exceed 1200 mg per day. Children ages 12 years or older may take approximately 600 to 1200 mg orally every 12 hours, not to exceed 2400 mg per day.

How to Use Mucinex

No matter which form or strength of Mucinex you choose, a few helpful tips always apply when you take the medication. Whether you choose to take Mucinex with or without food, it is recommended that you drink a full glass of water while taking it and extra fluids during your entire course of treatment. Without enough hydration, your body will not be able to properly loosen and thin the mucus in your airways. When using the table form of the medication, do not crush, chew, or break the tablet, as this can impact the medication’s effectiveness. Mucinex that includes a cough suppressant will stop you from coughing, but otherwise, you should expect your cough to continue as the medication works. Some people feel tired after taking Mucinex, while others feel more alert, so you should not drive or operate heavy machinery until you know how it affects you. You should see a doctor if your cough worsens or you get a fever, rash, or headache, or your cough lasts more than seven days.

Side Effects

The side effects associated with Mucinex are generally mild and usually do not require medical attention. Some people experience side effects when they first start taking Mucinex but find that they subside as their bodies adjust to the medication. Some side effects associated with Mucinex can be prevented, so if you are concerned about experiencing them, you should talk to your doctor about ways to prevent them. Common side effects of Mucinex include:

Dizziness
Nausea
Vomiting
Stomach upset
Stomach pain
Less common side effects of Mucinex include:
Drowsiness
Skin rash
Persistent Headache

If you experience any of the following symptoms, you may be experiencing an allergic reaction to Mucinex or may need to contact the poison control center. Seek medical advice or medical attention immediately if you experience any of the following:

Swelling, itching, or redness of the face
Tongue swelling
Difficulty talking or breathing
Skin rash or hives

Precautions for Pregnant and Nursing Women

Because Mucinex is an FDA-designated Class C drug for pregnant women, the full effects of the medication on unborn babies have not been conclusively studied, and use during pregnancy is recommended only when the benefit outweighs the risk. Existing data does not show an association between Mucinex and birth defects, but there is no controlled data on human pregnancy currently available. Because of the lack of data surrounding Mucinex’s effect on unborn children, it is recommended that you talk to your doctor before using the medication, even though it may be purchased over the counter. Although no studies exist that confirm that Mucinex passes through breast milk, the manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, the mother should make a decision to either discontinue nursing if using Mucinex or discontinue use of the drug. Nursing mothers should speak to their doctors prior to taking Mucinex.

Deciding to Take Mucinex

Although it is offered over the counter, Mucinex is not for everyone. The medication may not be suitable for people with a persistent cough due to asthma, chronic bronchitis, emphysema, or smoking, or who have a cough producing excessive amounts of phlegm. Pregnant and nursing mothers should use caution when using Mucinex and should speak to their doctors prior to taking the medication.

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how long does mucinex stay in your system

Mucinex DM contains 600 mg of guaifenesin and 30 mg of dextromethorphan. Based on its half-life, it is estimated that a healthy individual can get rid of DXM within 11 to 22 hours. Can I cut NyQuil LiquiCaps and just take the liquid inside? I am about to start DayQuil as I have a cold. Many people take Mucinex to relieve chest or sinus congestion. Guaifenesin does not need to be taken with food; however, it can be taken with food if it upsets … anyway, long story for short question – anyone know how long it will take the xeljanz to leave my system? To get rid of DXM, the liver converts it into a metabolite called dextrorphan. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mucinex only for the indication prescribed. Products in this range typically contain one or both of these two ingredients: 1. An overdose of acetaminophen can damage your liver or cause death. Conversely, some people report that guaifenesin keeps them awake. It is classified as a morphinan drug and is an active ingredient within many over-the-counter (OTC) formulations utilized to treat allergies, coughing, influenza, and more. I don’t want the outer shell since it has gelatin in it. That’s why Mucinex® has developed a variety of products to address these symptoms and help you navigate cold and flu season. Updated October 8, 2020. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Both versions of Mucinex DM last 12 hours per dose. The product is stored in a secure location where consumers do not have direct access. Cocaine: 72 hours Xanax: 14 days Methamphetamine: 7 days Heroine: about 48 hours For the fast metabolized drugs, it should be out of the baby’s system within 3 days. In fact, the brand name tablets contain a ‘bilayer delivery system’. Tips. Mucinex DM contains guaifenesin, just like regular Mucinex but also has the added ingredient of dextromethorphan, a cough suppressant. It will be out of your system in two more hours and then you can have the wine Please let me know if you need any more information Ask Your Own Medical Question In our latest question and answer, our pharmacist discusses how long each dose of Mucinex lasts. Do not use this medicine to make a child sleepy. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. This makes it easier for mucus trapped in the airways to be coughed out. May not be suitable for people with a persistent cough due to asthma, bronchitis, emphysema or smoking, or who have a cough that is producing excessive amounts of phlegm. How long does mucinex stay in your system, meaning when is how long does mucinex stay in your system, meaning when is it safe to drink a couple of glasses of wine/ … read more antidepressants, such as amitriptyline or imipramine, or monoamine oxidase inhibitors, such as isocarboxazid, phenelzine, or selegiline, other cough and cold remedies that may also contain guaifenesin, some medications used to treat high blood pressure. Visit Exposure to COVID-19 to learn more about how to monitor your health and protect your community if you’ve been exposed to a person with COVID-19. … my doctor told me that it doesn’t stay in your system too long. Tell your doctor if your condition lasts longer than 7 days. Let your close contacts know that they need to stay home and monitor their health even if the health department does not call them. Copyright 1996-2021 Drugs.com. Select one or more newsletters to continue. MUCUS ACTS AS A BARRIER. This medication is for temporary use only. Subscribe to Drugs. com newsletters for the latest medication news, new drug approvals, alerts and updates. There are a variety of Mucinex (guaifenesin) products on the market and how long each medications lasts depends on which product you are using. Dextromethorphan HBr: An “antitussive” (a.k.a cough medication) that works on your b… Several combination products also contain guaifenesin. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. COVID-19 is a serious respiratory disease, but how does it really affect your lungs if you get infected? Talk to your pharmacist or doctor before taking any other products for a cough or cold. Swallow the capsule whole and do not crush, chew, break, or open it. The phase IV trial will monitor drug safety outcomes that are personalized to your gender and age (0-99+). American Addiction Centers. On Feb, 19, 2021 Here’s what coronavirus can do to your lungs in mild-to-moderate, severe, and critical cases. Do not drive until you know how guaifenesin affects you. Examples of several popular over-the-counter formulations with DXM as an ingredient include: Vicks NyQuil/DayQuil, Mucinex DM, Robitussin, and more. 4. Updated December 17, 2019. My stomach issues were better thin a week. As Mucinex lasts 12 hours per dose, it is indicated for twice daily dosing. The empty tablet shell may be visible in the stool. Drink extra fluids while you are taking Mucinex as these will help loosen the congestion and lubricate your throat. Mucinex DM is an over-the-counter medication. Mucus traps inhaled particles (like dust, allergens, bacteria, or viruses) and keeps them from getting deeper into your lungs. Thank you for your query. MedlinePlus. Do not take this medication for more than 7 days unless your doctor tells you to do so. The tablet is sometimes broken in half to give the correct dose. Speak to your doctor about how drug interactions should be managed. Updated November 25, 2019. Stop taking it and call your doctor if your symptoms don’t go away or if they come back. Brand Mucinex is available in two strengths, regular and ‘Maximum Strength’. It has two active ingredients: guaifenesin and dextromethorphan. Doing the math, the Claritin (loratadine) is effectively out of a person’s system in 3-5 days, except in geriatric patients it could possibly take up to 10 days. Guaifenesin (the active ingredient of mucinex) has a half life of only 1 hour which means that after 6 hours almost all of it is eliminated. Please feel free to reach out to him directly if you have any inquiries or want to connect! should it not be out of my system by now? See your doctor if your cough worsens, is accompanied by other symptoms such as a fever, rash, or a persistent headache, or lasts for more than seven days. That means after 2.88 hours half of it is gone. In fact, the brand name tablets contain a ‘bilayer delivery system’. 2. So half a day or so will result in complete elimination of the medicine from the body. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death. Do not give to children under the age of twelve. You may inform your parents or a guardian if you suspect that there is any side effect or drug interaction bothering you. Most colds consist of three phases, and your symptoms can vary during each phase. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Other Mucinex products contain a combination of medications that treat cough, sinus … DXM (Dextromethorphan) is an antitussive agent comprised solely of a methylated dextrorotatory analogue of levorphanol, a semisynthetic non-opioid morphine derivative. Mucines DM contains gextropmethorphan and guaifenesin. We comply with the HONcode standard for trustworthy health information -. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Most adults recover from a cold in about 7 to 10 days, but a common cold can last longer in children. Do not crush, chew or break this tablet. Brand name Mucinex products will last about 12 hours per dose. The half life of Mucinex is 2.88 hours. Talk with your doctor first before using Mucinex if you are pregnant or breastfeeding. Below, we discuss how long each Mucinex product lasts. The cold and flu have something in common: coughing and congestion. Reckitt Benckiser, Inc. https://www.drugs.com/pro/mucinex.html. mucinex (guaifenesin) dm 12 hour, 2 days later and can still taste it and smell it. Updated December 10, 2019. i did a bit of googling and didn’t find anything useful yet. Mucinex is a brand (trade) name for guaifenesin. May be used to aid in the coughing up of phlegm and mucus in people with a chesty cough. You’ll usually start to feel less anxious within 1 to 2 hours of taking it. How long does oxcarbazepine stay in your system after you stop taking them? The first layer delivers a dose of the drug immediately after administration while the second layer releases over a time period of 12 hours. The regular strength tablets contain 600 mg of guaifenesin while the maximum strength contains 1,200 mg of guaifenesin. Dangers of Mixing Alcohol and Codeine. Mucinex (guaifenesin) [Package Insert]. Once I take it, when can I expect it to work? For slow metabolized drugs, it will take up to a week. They need to stay moist to do their job. Get your prescription refilled before you run out of medicine completely. i started taking mucinex dm last night. After another 2.88 hours, half of the remaining amount is there, after another 2.88 hours … Mucinex is available as a generic under the name guaifenesin. Harvard Health Publishing. This chemical has a half-life of about 1.7 to 5.4 hours. Just because Xanax stays in your system, doesn’t mean that you feel its effects as long. Pseudoephedrine has a half-life of about 12 hours which means it’s going to take a minimum of three or four days to clear your system.

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Can I take expired Mucinex products?

What is MUCINEX

Mucinex is a brand name for drug guaifenesin which belong to the class of expectorants. It has wide range of products covered under the brand name of MUCINEX. It helps relieving congestion in chest and throat. Mucinex is used to reduce chest congestion caused by the common cold, injection and allergies.

Mucinex are available in various dosage forms like tablets, liquid-gels, nasal spray and liquids. It is available for all age groups from children, adults and aged individuals. The combination medication of guaifenesin, dextromethorphan and pseudoephedrine are used for treating sinus and multi symptom conditions.

Different products of mucinex:

MUCINEX : Guaifenesin 600mg ER tablet
MUCINEX Maximum strength : Guaifenesin 1200mg ER tablet
MUCINEX DM : Dextromethorphan Her 30mg + Guaifenesin 600mg tablet ER tablet
MUCINEX DM Maximum strength : Dextromethorphan HBr 60mg + Guaifenesin 1200mg ER tablet
MUCINEX D : Dextromethorphan 60mg + Guaifenesin 600mg ER tablet
MUCINEX D Maximum strength : Dextromethorphan 120mg + Guaifenesin 1200mg ER tablet
MUCINEX SINUX-MAX Nasal spray : Oxymetazoline hydrochloride (0. 05%)
MUCINEX SINUS-MAX Pressure & pain : Acetaminophen 650mg + Guaifenesin 400mg + phenylephrine 10mg liquid
MUCINEX SINUS-MAX Maximum strenght Pressure & pain caplets : Acteaminophen 325mg + Guaifenesin 200mg + phenylephrine 5mg
MUCINEX SINUS-MAX Maximum strenght Pressure & pain liquid : Acteaminophen 325mg + Guaifenesin 200mg + phenylephrine 5mg
MUCINEX SINUS-MAX Maximum strenght Pressure & pain relief caplets : Acteaminophen 325mg + Guaifenesin 200mg + phenylephrine 5mg
MUCINEX SINUS-MAX congestion relief caplets : Acetaminophen 325mg + Guaifenesin 200mg + phenylephrine HCL 5mg
MUCINEX FAST-MAX Clear & cool, severe congestion & cough liquid : Dextromethorphan HBr 10mg + Guaifenesin 200mg + phenylephrine 5mg
MUCINEX MAX STRENGH clear & cool, cold , cough and sore throat

and many more MUCINEX also has wide range of products for childrens :

CHILDREN’S MUCINEX MULTI-SYMPTOM COLD LIQUID
CHILDREN’S MUCINEX NIGHT TIME MULTI-SYMPTOM COLD LIQUID
CHILDREN’S MUCINEX COUGH, COLD & SORE THROAT
CHILDREN’S MUCINEX CONGESTION AND COUGH LIQUID
CHILDREN’S MUCINEX CHEST CONGESTION LIQUID
CHILDREN’S MUCINEX STUFFY NOSE & COLD LIQUID
CHILDREN’S MUCINEX COUGH MINI MELTS
CHILDREN’S MUCINEX CHEST CONGESTION MELTS
CHILDREN’S MUCINEX DAY AND NIGHT LIQUID

Where is the expiration date on mucinex bottle?

Can I use expired MUCINEX

In my opinion and according to the guidelines provided by FDA and other regulatory authorities any medicine, drug, OTC or any consumer product should not be used after its expiration date. After the expiration date manufacturer no long provides guarantee of its 100% safety and efficacy of its products. Mucinex is available in various dosage forms like liquids, tablets, liquid gels, mini melts and extended release tablets.

Degradation is initiated once it passes its expiration date, rate of degradation is also depended on dosage form and other factors. Liquids are porn degradation than any other form like tablets and capsules.

After expiration date drug or product may or may not cause side effects. This side effects may be any severe, mild and moderate. Basically after expiration date slowly and steadily it reduces its efficacy and potency and increases side effects.

Conditions in which mucinex can be used

Mucinex is a brand name for generic drug named Guaifenesin. It is commonly used for:

common cold,
cough,
congestion,
infections, and
allergies

In combination with other drugs it is used for some other uses too:

sinus
pressure and pain
sore throat
stuffy nose and cold ,etc

Side effects observed after the use of expired mucinex

Side effects are any unusual or uncommon effects occurring in the body system after its use. This side effects may range from minor, major or severe side effects. The minor side effects are:

diarrhea
dizziness
headache
hives
nausea
vomiting
skin rash
stomach pain
gastrointestinal upset
anaphylactic reaction
arrhythmia
tachycardia

Can I use mucinex during pregnancy and lactation

Any major side effects of using mucinex is not known yet. It is also not known weather it passes into the mother’s milk to baby or crosses the barrier to reach fetus. So, it is always better to consult your physician before its use during pregnancy and lactation.

Can mucinex causes changes in heart beat

Yes, combination product of mucinex which contains pseudoephidrine i.e MUCINEX-D, this ingredient is responsible for changes in heart beats. Commonly this ingredient increases heart beats.

Can I use mucinex -DM with alcohol

Mucinex only containing guaifenesin does not have major side effects when it is used with alcohol but mucinex-DM containing guaifenesin and dextromethorphan can not be used with alcohol like ethanol beacuse it may cause increase nervous breakdown or side effects due to dextromethorphan. The common side effects are dizziness, drowsiness and difficulty in concentrating.

Can I take mucinex and grapefruit together

You should avoid taking mucinex and grapefruit , orange, milk products as well as any caffeinated products may reduce the absorption of drug in the body and for that you may get under effect of the drug then the normal effect.

Can Mucinex causes drowsiness

Yes, mucinex may cause drowsiness because of the chemical ingredients present in it. Dextromethorphan and diphenhydramine which are the chemical constituent in Mucinex D, Mucinex DM, Mucinex night time and other Mucinex multi symptom products. This chemical molecule or entity is responsible for causing drowsiness after using it. So, it is mostly recommended to consumers to use it before sleep.

Is Mucinex non drowsy available

Yes, mucinex day time which is non drowsy product of mucinex. This is formulated with an aim of achieving non drowsiness effect during day time which is required for fulfilling the daily day time activities.

Can Mucinex affects blood pressure

Yes, Mucinex can elevate the blood pressure of an individual using it. Mucinex contains an ingredient called pseudoephedrine which is responsible for blood pressure elevation in an individual, which blood pressure is raised is not known properly the oxygenated or deoxygenated blood pressure.

“Can I use Vicks Dayquil or Nyquil with Mucinex DM together?“
“Can you take Mucinex (guaifenesin) and Sudafed (pseudoephedrine) together while pregnant?”
“Does hydrogen peroxide have an expiration date? Can I use expired hydrogen peroxide?“

How Long Does Mucinex Work Free Recipes

How Effective Is Mucinex for Cough and Congestion? …

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Among the means aimed at improving the rheological properties of blood, one of the most widely used is Trental (pentoxifylline). The authors provide the main indications for the use of Trental and evidence of the effectiveness of the drug in the treatment of neurological disorders, such as vascular cognitive disorders, transient ischemic attacks, chronic discirculatory encephalopathy, chronic cerebrovascular accident, etc.

Trental (pentoxifylline) is a drug from the group of vasodilators, chemical structure (methylxanthine derivative) close to theobromine and theophylline. Its main pharmacological properties are associated with the ability of nonspecific inhibition of type 4 phosphodiesterase activity, which leads to an increase in the content of cyclic 3 ‘, 5’-AMP in platelets and ATP in erythrocytes and a decrease in the intracellular concentration of calcium ions. Clinical studies indicate that the drug has a pronounced positive effect on microcirculation and hemodynamics due to vasodilation with a decrease in total and regional peripheral vascular resistance, an increase in systolic and cardiac output without significant changes in heart rate [14].

After almost complete absorption, pentoxifylline is metabolized in erythrocytes and liver. The main active metabolite 1- (5-hydroxyhexyl) -3,7-dimethylxanthine (metabolite-1) has a plasma concentration that is 2 times higher than the initial concentration of pentoxifylline. Pentoxifylline and its metabolites do not bind to blood plasma proteins. The absolute bioavailability of the original substance is 19 ± 13%. When taken orally, pentoxifylline is rapidly and almost completely absorbed, the half-life is 1.6 hours, with intravenous administration of 100 mg – about 1.1 hours.With severe renal impairment, the excretion of metabolites is slowed down, with impaired liver function, the half-life of pentoxifylline is lengthened, and the absolute bioavailability increases. More than 90% of the accepted dose of pentoxifylline is excreted through the kidneys in the form of unconjugated water-soluble metabolites, 3-4% – with feces [14].

Trental improves the rheological properties of blood (fluidity) by increasing the deformability of erythrocytes (reduced in pathology), as well as inhibiting platelet aggregation and reducing increased blood viscosity.Trental improves microcirculation in areas of impaired blood circulation. Providing a weak myotropic antispasmodic effect, the drug slightly dilates the coronary vessels. The mechanism of its action is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in the cells of vascular smooth muscles and blood cells.

The following indications for the appointment of Trental in neurology can be distinguished: peripheral circulatory disorders of atherosclerotic genesis (intermittent claudication, diabetic angiopathy), cerebrovascular accident, post-stroke conditions, the consequences of cerebral atherosclerosis (decreased concentration, dizziness, memory impairment).Trental is a highly effective drug for the complex therapy of a number of neurological diseases associated with microcirculation disorders; it is well tolerated and can be combined with many drugs. In this case, the dose of the drug and the duration of treatment can vary widely depending on the specific clinical situation. This is facilitated by the presence of various dosage forms of the drug with a fairly wide range of doses (tablets 400 mg No. 20, tablets 100 mg No. 60, ampoules 100 mg / 5 ml) [11].Trental tablets are recommended to be taken at 400 mg (prolonged form) 2-3 times a day during or immediately after meals, swallowing the tablets whole and drinking them with a sufficient amount of water [14]. Pentoxifylline is effective between weeks 2 and 4, but treatment should be continued for at least 8 weeks. For intravenous administration of pentoxifylline, single infusions from 200 to 300 mg (but not more than 1200 mg per day) are used [1]. There are results of open studies of intravenous use of Trental for 10 days at a dose of 1200 mg (the maximum daily dose registered in the Russian Federation) to 1500 mg per day, clinical improvement was found in 9 out of 10 patients [3].This improvement was combined with a significant increase in erythrocyte deformability. It also reported a marked improvement in the condition of the surveyed who received Trental at a dose of 300-600 mg per day for more than 7 weeks, compared with the control group without treatment. The effect of pentoxifylline was also assessed by the average duration of hospital treatment – in the case of using this drug, a decrease in the duration of hospitalization was noted from 7.5 to 4.8 weeks. In acute vascular disorders caused by cerebral thrombosis, embolism and intracranial hemorrhage, the use of Trental at a dose of 600 mg per day for 1-7 months had a similar effect: a significant improvement in 60% of cases and an average improvement in 25%, no effect was observed in 15%.The therapeutic effect of pentoxifylline was also studied in fresh lacunar disorders of cerebral circulation: 40 patients were treated with Trental at a dose of 800-1200 mg per day for 3 months, which led to a complete or partial regression of neurological deficit in 34 patients, while an improvement in erythrocyte deformability was found. as well as a decrease in the aggregation and viscosity of blood plasma [3].

Trental is well tolerated by patients, taking the drug in an adequate daily dosage of 400-600 mg is extremely rarely accompanied by side effects such as flushing of the skin, palpitations, hot flashes, weakness, headache.These manifestations are usually mild, do not require specific treatment or discontinuation of the drug (as a rule, it is enough to reduce the daily dose). In cases of individual intolerance, hemorrhagic syndromes, gastric ulcer and duodenal ulcer, severe intractable arterial hypotension, the drug should be prescribed with caution [14]. Considering that the administration of some direct and indirect antihypertensive drugs simultaneously with pentoxifylline can potentiate the effect, and therefore the advisability of combined treatment should always be considered individually [6].It is very important that the drug prescribed in rational dosages does not cause negative redistribution of blood in the cranial cavity (intracerebral robbery syndrome).

Trental is widely used in the treatment of patients with various forms of chronic progressive disorders of cerebral circulation – discirculatory encephalopathy (DE). The approach to the treatment and secondary prevention of chronic disorders of cerebral circulation implies the most complete elimination of cardiovascular risk factors, including strict control of blood pressure and blood glucose, the use of antiplatelet agents and statins.Pentoxifylline improves microcirculation by increasing the deformability of erythrocytes, reducing platelet aggregation and the viscosity of whole blood. The beneficial effect on the properties of red blood cells distinguishes the original drug Trental from generics. Pentoxifylline stimulates the release of prostacyclin and reduces vasospasm. A study in which the incubation of erythrocytes from healthy donors with pentoxifylline was carried out for 15 minutes, followed by registration of the aggregation index, the size of aggregates and the rate of aggregation (optical microscopy), measuring (on an automatic rheometer) the fluidity of erythrocyte suspensions (values, inverse viscosity), revealed statistically a significant decrease in all three indicators of erythrocyte aggregation and suspension viscosity [8].The study compared Trental with three generic drugs. In terms of the effect on platelet aggregation, Trental significantly exceeded generics (decrease in the indicator by 46 and 20–35%, respectively). Similar data were obtained when studying the viscosity of the suspension (decrease by 16 and 6–10%, respectively).

The presence of lesions in the corresponding parts of the cerebral cortex can be accompanied by a violation of higher cerebral functions (apraxia, agnosia, aphasia), although the functional deficit does not always correspond to the localization of pathological changes.Emotional disturbances are manifested by apathy, symptoms of depression. Some patients have dyssomnic disorders in the form of increased sleepiness and disturbances in the sleep-wake cycle. The clinical picture of DE is characterized by progressive neurological, emotional, and cognitive impairments. DE stage I is characterized by the predominance of subjective disorders in the form of emotional instability, increased irritability, dysmnestic and dyssomnic disorders, decreased mental performance, while focal neurological deficit is not observed.DE stage II is distinguished by the presence of asthenic disorders, significant intellectual and emotional disorders, and small focal neurological symptoms. In stage III DE, intellectual-mnestic disorders (dementia), clear focal (multifocal) neurological symptoms prevail. Pyramidal disorders in patients with DE rarely reach the severity of paresis. Patients lose their ability to work, become dependent on others, and often need constant outside care.It is the combination of emotional and cognitive impairments that is the cause of social maladjustment in many patients with DE [7].

In order to clarify the efficacy of Trental (pentoxifylline) in patients with chronic cerebrovascular accidents in the outpatient network of Moscow, a study was conducted that included 55 patients with the consequences of non-disabling stroke who received prolonged-release pentoxifylline at 1200 mg per day [2].Before and after treatment, the patients underwent a standard comprehensive examination using neurological and neuropsychological rating scales, and a study of the rheological properties of blood. Neurological status was assessed using the Bartel and Matthew grading scales, a neuropsychological study using a short questionnaire for the assessment of mental functions (MMSE), the Beck depression scale and the Wechsler test, and an assessment of the quality of life of patients. The positive dynamics of a number of neurological indicators was noted, the level of fibrinogen in the blood decreased, and the MMSE indicators significantly increased.Thus, the positive effect of Trental in high doses on the restoration of cognitive functions was revealed.

Chronic cerebrovascular insufficiency – the most common cerebrovascular pathology – is also one of the most common causes of disability. Among the factors leading to chronic insufficiency of cerebral circulation, there are atherosclerosis, hypertension and their combinations, diabetes mellitus, various diseases, including systemic ones, accompanied by vascular damage, blood diseases leading to an increase in its viscosity.The strategy for the treatment of chronic cerebrovascular insufficiency involves the impact on the main pathological process, the basic links of which are hypertension and atherosclerosis. An adequate combination of antihypertensive drugs with diuretics, statins, adrenergic blockers, tranquilizers, antidepressants leads in most cases to encouraging results. Therapeutic measures for chronic cerebral circulatory insufficiency should be aimed at improving cerebral hemodynamics and increasing the functionality of the brain [1].

An open comparative randomized analysis of 3-year follow-up of the use of the drug Trental in patients with DE [16] was carried out. At the initial stage of the study [15], 57 patients (27 men, 29 women) aged 63.1 ± 5.8 years with DE were observed, who received Trental (tablets) 100 mg 3 times a day. The patients were followed up for 8 months with two courses of treatment for 2 months: in the 1-2nd and 7-8th months of observation. A total of 132 patients (68 men, 64 women) aged 67.3 ± 5.1 years with DE stage III, who received Trental 400 mg per day against the background of basic therapy, were subsequently examined [16].The duration of treatment courses was 2 months. Against the background of the treatment (three courses per year), the patients showed a stabilization of the course of chronic cerebral vascular insufficiency, the risk of stroke decreased compared to the control group receiving basic therapy (acetylsalicylic acid + dipyridamole, betaxolol, glycine), approximately 2 times.

The effectiveness of the use of prolonged forms of pentoxifylline in the treatment of patients with TIA is confirmed by the following results: overall clinical efficacy – 86%, improvement in the subjective assessment of the dynamics of symptoms by patients – 87%, decrease in the average duration of inpatient treatment by 1.5 times [3].Two studies evaluated the prophylactic efficacy of pentoxifylline (Trental) and combination antiplatelet therapy in TIA. Both studies used oral pentoxifylline (1200 mg daily) or the antiplatelet therapy aspirin (1050 mg daily) in combination with dipyridamole (150 mg daily). It was found that new ischemic episodes during the 12-month follow-up in the first and second studies were noted in 10 and 13% of patients taking pentoxifylline, and in 28 and 31% in the group receiving combined antiplatelet therapy.The mortality rate of patients was significantly lower when using pentoxifylline (14.2% versus 32.5%). The frequency of episodes of cerebrovascular accidents over a 12-month period in both groups was less than 5%, which is significantly lower than in patients before treatment [12]. Another comparative TIA study showed that treatment with pentoxifylline (total dose of 500 to 700 mg per day) led to faster improvement in mood and a significant reduction in motor and speech deficits than treatment of xanthinol with nicotinate (total dose of 2250 to 3150 mg per day) [fourteen].

On the basis of the Scientific Center of Neurology of the Russian Academy of Medical Sciences, 44 patients with chronic cerebrovascular diseases (CCVD) were examined: 12 patients suffered from acute cerebrovascular accident, 4 suffered from transient ischemic attacks, 28 had DE I – II stages [10]. Metabolic syndrome (MS) was diagnosed in 22 of the examined patients.Therapy with pentoxifylline (Trental) was carried out for 21 days at a dose of 100 mg daily as an intravenous infusion. To assess the state of hemorheology, the indicators of blood viscosity at various shear rates, hematocrit, platelet aggregation under the influence of aggregation inducers – ADP and adrenaline – were studied. Aggregation and deformability of erythrocytes were determined on a laser optical rotary cell analyzer. The clinical picture of the examined patients was dominated by signs of DE: decreased memory, concentration, dizziness, headache, tinnitus, sleep disorders, etc.To objectify the severity of neurological symptoms, the Bartel index was used, the value of which was slightly higher in the group of patients without MS – 67% – compared with the group of patients with MS – 62%. In the study of erythrocyte aggregation, more significant disorders were found in patients with concomitant MS. The amplitude of aggregation, reflecting the final size of erythrocyte aggregates, is also significantly higher in patients with MS. After the therapy, there was a significant regression of neurological symptoms – the Bartel index increased from 62 to 87%.On the 21st day of therapy, a significant improvement in hemorheological parameters was noted. The study showed the high efficacy of pentoxifylline (Trental) in the treatment of hemorheological and hemostatic disorders in patients with chronic cerebrovascular diseases on the background of MS. Therapy with pentoxifylline (Trental) leads to a significant regression of neurological symptoms, an improvement in hemorheological and hemostatic parameters. The unique effect of pentoxifylline on erythrocyte aggregation and deformability – one of the leading causes of hemorheology and microcirculation disorders in MS – makes pentoxifylline the drug of choice in the treatment of CCVD patients with concomitant MS.

In 2008, a meta-analysis of 5 randomized, placebo-controlled trials was carried out, which involved 763 patients who received pentoxifylline (Trental) [5]. It was noted that the risk of death during the first 4 weeks of the disease was slightly reduced in the study group compared with patients receiving placebo, while in one of the studies the decrease in mortality was regarded as significant. It was found that the use of Trental in the acute stage of the disease did not have a significant effect on the long-term outcomes of stroke, which may be associated with a number of concomitant factors (timing of treatment initiation, features of the pathogenetic subtype of stroke, etc.).). At the same time, the authors of the meta-analysis note the undoubted positive effect of using Trental in comparison with comparison drugs, however, due to the heterogeneous design of the studies, in particular, the effectiveness criteria used, the results cannot be completely comparable with each other, which makes it necessary to conduct new studies. The main effect of pentoxifylline in cerebral diseases – an increase in cerebral blood flow (in the absence of steal syndrome) – is realized through several mechanisms [7]:

In order to prevent acute disorders of cerebral circulation and the possible development of post-stroke cognitive impairments, drugs that affect the rheological properties of blood are widely used.It is noted that against the background of the use of Trental, cerebral blood flow increases due to an increase in the lumen of blood vessels without the occurrence of steal syndrome. In addition, the accumulation of cyclic AMP in platelets and erythrocytes has some antiplatelet effect, increases the deformability of blood cells and helps to reduce its viscosity. The effectiveness of Trental in chronic cerebral vascular insufficiency has been confirmed by numerous clinical observations. More than 20 randomized controlled trials performed in European countries have shown that against the background of the use of Trental in patients with vascular dementia and less severe cognitive impairment, there is a statistically significant positive dynamics of cognitive parameters and other neurological disorders [4].In patients with vascular dementia who received antiplatelet therapy (or anticoagulants for cardioembolism), the risk of death is markedly lower, but there is no convincing evidence that the rate of progression of cognitive impairment also decreases.

A 2009 policy review demonstrated the efficacy of Trental (pentoxifylline) in vascular dementia in a double-blind, randomized, placebo-controlled study using 400 mg daily for 36 weeks.The results of another study, which also showed a significant improvement in the condition of patients who received Trental in a daily dose of 1200 mg in two courses of 12 weeks with a break of 4 weeks. At the same time, the drug not only prevented the progression of cognitive impairments, but also improved the rheological properties of blood [9].

General side effects	Mucinex	Mucinex DM
constipation	✓
diarrhea	✓				dizziness	✓	✓
headache	✓	✓
nausea, vomiting, or both	✓	✓
							✓	✓
Serious side effects	Mukinex	Musinex DM
confusion	✓
feeling nervous			✓	✓
very severe nausea or vomiting, or both	✓