How and when to take aspirin for pain

Dosage and strength

The dose of aspirin that’s right for you depends on the kind of aspirin you’re taking, why you’re taking it and how well it helps your symptoms.

Dosage and strength of aspirin tablets

Aspirin usually comes as 300mg tablets.

The usual dose is 1 or 2 tablets, taken every 4 to 6 hours.

Important

Do not take more than 12 tablets in 24 hours. Wait at least 4 hours between doses.

Dosage and strength of aspirin suppositories

Aspirin suppositories come in 2 strengths. They contain 150mg or 300mg of aspirin. You can buy them from a pharmacy.

If you’re using:

• 150mg – the usual dose is 3 to 6 suppositories, this is 450mg to 900mg, used every 4 hours. The maximum dose is 24 of the 150mg suppositories in 24 hours.
• 300mg – the usual dose is 1 to 3 suppositories, this is 300mg to 900mg, used every 4 hours. The maximum dose is 12 of the 300mg suppositories in 24 hours.

If you need a dose of 450mg or 750mg, your doctor or pharmacist will give you a mixture of strengths and explain how to use them.

Important

Do not use more than 24 of the 150mg suppositories or 12 of the 300mg in 24 hours. Wait at least 4 hours between doses.

How to take it

Different aspirin tablets and how to take them

Aspirin tablets come as different types including:

• standard tablets that you swallow whole with water
• soluble tablets that you dissolve in a glass of water
• enteric coated tablets that you swallow whole with water

Enteric tablets have a special coating that are gentler on your stomach. Do not chew or crush them because it will stop the coating working. If you also take indigestion remedies, take them at least 2 hours before or after you take your aspirin. The antacid in the indigestion remedy affects the way the coating on these tablets works.

You can buy standard aspirin tablets and soluble tablets from both pharmacies and supermarkets.

How to use aspirin suppositories

Aspirin suppositories are medicine that you push gently into your anus (bottom).

Read the instructions in the leaflet that comes with the suppositories.

1. Go to the toilet beforehand if you need to.
2. Wash your hands before and afterwards. Also clean around your anus with mild soap and water, rinse and pat dry.
3. Unwrap the suppository.
4. Stand with one leg up on a chair or lie on your side with one leg bent and the other straight.
5. Gently push the suppository into your anus with the pointed end first. It needs to go in about 2cm to 3cm (1 inch).
6. Sit or lie still for about 15 minutes. The suppository will melt inside your anus.

H

ow to use aspirin mouth gel

For mouth ulcers or sores, massage about a centimetre (half an inch) of gel onto the sore area. Apply it to the inside of your mouth or gums every 3 hours as needed.

If you have dentures (false teeth), take them out before you apply the mouth gel. Then wait at least 30 minutes after applying the gel before putting your dentures back in your mouth.

You can buy aspirin mouth gel (Bonjela) from pharmacies and supermarkets. Do not use Bonjela on children. You can give Bonjela Teething Gel or Bonjela Junior to children as they do not contain aspirin.

How long to take aspirin for

If you’re taking aspirin for a short-lived pain, like toothache or period pain, you may only need to take it for 1 or 2 days.

If you’ve bought it from a shop, supermarket or pharmacy and need to use aspirin for more than 3 days, ask your doctor or pharmacist for advice.

If your doctor has prescribed your aspirin, take it for as long as they recommend.

If you take too much

Taking or using 1 or 2 extra tablets or suppositories is unlikely to be harmful.

The amount of aspirin that can lead to overdose varies from person to person.

Urgent advice: Contact 111 for advice now if:

You take more than the daily limit of 12 tablets in 24 hours and get side effects such as:

• feeling sick (nausea)
• ringing in the ears (tinnitus)
• hearing problems
• confusion
• feeling dizzy

Go to 111. nhs.uk or call 111

If you need to go to A&E, do not drive yourself – get someone else to drive you or call for an ambulance.

Take the aspirin packet or leaflet inside it, plus any remaining medicine, with you.

Page last reviewed: 10 December 2021

Next review due: 10 December 2024

How and when to take low-dose aspirin

Always follow the instructions from your doctor, or the instructions inside the medicine packet on how to take it.

Take low-dose aspirin once a day. Do not take it on an empty stomach. It’s best to take it with or just after food. This will make it less likely to upset your stomach.

Dosage

Your doctor will discuss what dose is right for you. It’s important to take low-dose aspirin exactly as recommended by your doctor.

The usual dose to prevent a heart attack or stroke is 75mg once a day (a regular strength tablet for pain relief is 300mg).

The usual dose for pregnant women is either 75mg or 150mg, taken once a day.

The daily dose may be higher, up to 300mg once a day, especially if you have just had a stroke, heart attack or heart bypass surgery.

Different types of low-dose aspirin tablets

Low-dose aspirin comes as several different types of tablet:

• tablets you swallow whole with water (standard)
• tablets that you dissolve in a drink of water (soluble)
• tablets that you swallow whole with water (enteric coated or gastro-resistant). These tablets have a special coating that means they may be more gentle on your stomach. Do not chew or crush them because it will stop the coating from working. If you also take indigestion remedies, take them at least 2 hours before or after you take your aspirin. The antacid in the indigestion remedy affects the way the coating on these tablets works

How long to take it for

If you’re taking low-dose aspirin for angina or to prevent a heart attack or stroke, you’ll usually need to take it for the rest of your life.

If you forget to take it

If you forget to take a dose of aspirin, take it as soon as you remember. If you do not remember until the following day, skip the missed dose and take your next dose at the usual time.

Do not take 2 doses to make up for a forgotten dose.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember to take your medicine.

If you take too much

Taking 1 or 2 extra tablets is unlikely to be harmful.

The amount of aspirin that can lead to overdose varies from person to person.

Urgent advice: Contact 111 for advice now if:

You take more than the daily limit of 12 tablets in 24 hours and get side effects such as:

• feeling sick (nausea)
• ringing in the ears (tinnitus)
• hearing problems
• confusion
• feeling dizzy

Go to 111.nhs.uk or call 111

If you need to go to A&E, do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the aspirin packet or leaflet inside it, plus any remaining medicine, with you.

Page last reviewed: 16 December 2021

Next review due: 16 December 2024

The effective dose of aspirin in the prevention of cardiovascular disease depends on the weight of the patient

It is known that the dose of acetylsalicylic acid (ASA) recommended for the primary prevention of cardiovascular disease (CVD) varies in different countries. However, in any region there is a tendency to prescribe the same dose for all patients. Thus, in Europe, the prophylactic dose of ASA is most often 75 or 100 mg per day, and in the USA – 162.5 or 325 mg per day. Despite the increasing focus on personalized medicine and the consideration of complex genomic and molecular factors in the choice of therapy, simple parameters such as patient height, weight, age, and gender are often overlooked. Meanwhile, on July 12, a meta-analysis of ten randomized controlled trials was published in the Lancet, including a total of one hundred and twenty thousand patients. The average weight of patients in various studies ranged from 60 to 81 kg. It has been shown that in the general population, taking 75-100 mg of ASA per day. led to a decrease in the risk of death from CVD, myocardial infarction or stroke by 12% (p = 0.0008), and in persons weighing 70 kg at a dose of 75-100 mg per day. did not decrease (p = 0.24), and at a dose of 325 mg per day. risk was reduced by 17% (RR 0.83, 95% CI 0.70-0.98, p = 0.028). Unfortunately, the subjects’ bleeding risk also increased with weight loss. Moreover, if the patient weighed 70-90 kg, then he did not receive significant benefit from ASA, and the risk of bleeding significantly increased. All results applied to both male and female participants.

ASA 75-100 mg per day. was also accompanied by a reduced risk of colorectal cancer in patients weighing 80 kg did not change (RR 1.08, 95% CI 0.83-1.39).

Patients weighing >70 kg require higher doses of ASA, which should generally lead to an increased risk of bleeding. Meanwhile, in the described meta-analysis, about half of the women and 80% of men weighed >70 kg, which means they needed a different dosing regimen. At the same time, the common practice in the United States of prescribing 325 mg of ASA per day is questionable, given the increased risk of bleeding and the proven effectiveness of lower doses. This requires a weighted risk assessment for each patient group. The authors of the study believe that the risk of bleeding does not depend on dose linearly, so the effectiveness and risk of different dosing regimens for each weight should be studied in future randomized clinical trials.

Overall, a number of commentators consider the findings of the study to be reasonable and consistent with current understanding of the effects of ASA. The same dose of the drug should not have the same effect in patients of different height, weight, age and baseline cardiovascular risk, but no previous clinical study has included a sufficient number of patients to clarify this issue. It was noted that the effect of the drug in men and women did not differ, but there was a strong correlation of sex with weight, which is why in previous studies the prevention of CVD in men could be less effective than in women.

The meta-analysis also points to a number of upcoming large randomized trials to elucidate the role of ASA in the primary prevention of CVD. The ARRIVE study will compare aspirin 100 mg with placebo in 12,000 people at moderate risk of CVD. In the ASPREE study, the same dose will be studied in 19,000 elderly patients (65 years and older). In the ASCEND study, 100 mg aspirin per day. will be compared with placebo in 15,000 diabetic patients without CVD. The use of ASA in the secondary prevention of CVD is already being explored in the ADAPTABLE study. It compares 81 mg and 325 mg aspirin in secondary prevention of CVD in 15,000 patients. If the research data are consistent with each other, the described results will be recognized as reliable.

Adapted from:

https://www. thelancet.com/journals/lancet/article/PIIS0140-6736(18)31133-4/fulltext

take aspirin

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Scientists told how to take aspirin correctly

Scientists told how to take aspirin correctly0003

American medical scientists led by Charles Hennekens, a researcher who was the first in the world to discover the preventive properties of aspirin for people with… :08

2020-02-18T20:21

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usa

discoveries – ria science

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aspirin

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90 002 MOSCOW, February 18 – RIA Novosti. American medical scientists led by Charles Hennekens, a researcher who was the first in the world to discover the preventive properties of aspirin for people with a predisposition to cardiovascular diseases, published updated recommendations for the use of this drug in the American Journal of Medicine. The authors attribute the need for such a publication with the fact that recently there have been a number of conflicting conclusions about the use of aspirin in the prevention of cardiovascular diseases. Some recommend using aspirin for people aged 40 to 70, who are at higher risk of a first heart attack or stroke, while others suggest that those over 70 can also use the drug. Over the past year, three large-scale trials of aspirin for primary prevention have been published in the United States, one of which showed a specific positive effect of the drug, while the other two did not reveal a clear result. As a result, doctors are confused about whether aspirin should be given for the primary prevention of heart attacks and strokes, and if so, to whom. must be applied with caution. To achieve maximum benefit, healthcare professionals must make individual clinical decisions in each case. Among the authors of the article is Charles Hennekens (Charles Hennekens) from the Florida Atlantic University Schmidt College of Medicine, the most respected scientist in this field, who since 1995 to 2005 was the third most cited medical researcher in the world; David DeMets, professor at the University of Wisconsin, and Marc Pfeffer, MD, professor of medicine at Harvard Medical School. “For an acute heart attack, all patients should receive 325 milligrams of regular aspirin immediately and daily after the event “To reduce the risk of sudden death,” Charles Hennekens said in a Florida Atlantic University press release, “In addition, after heart attacks and strokes, aspirin should be prescribed for a long time, unless there are special contraindications. However, in primary prevention, the balance of absolute benefits of aspirin is lower than with secondary prevention. The researchers emphasize that when prescribing long-term aspirin therapy to healthy people, each time it is necessary to proceed from the specific situation and characteristics of the body, primarily blood coagulation, in order to eliminate the risk of bleeding. But more important for primary prevention, from the point of view of scientists, is a healthy lifestyle, including smoking cessation, weight loss and increased daily physical activity, as well as proven drug therapy that has proven effective and confirmed by the attending physician. First of all, drugs containing statins for lipid modification, and blood pressure control drugs. “When the magnitudes of benefits and risks are the same, patient preference becomes more important,” says Hennekens. “Whether preventing a first heart attack or stroke is more important for him, than the risk of gastrointestinal bleeding. According to the authors of the recommendations, an important role belongs to medical professionals, whose judgments can influence the choice of patients. For example, in patients with metabolic syndrome who have a combination of cardiovascular risk factors such as overweight or obesity, hypertension, high cholesterol, and insulin resistance, aspirin is likely to be recommended. But in any case, this should be done by the attending physician. “There seems to be no general recommendations for aspirin in primary prevention,” the scientist concludes.

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Science, USA, Discoveries – RIA Science, Health, aspirin

MOSCOW, February 18 – RIA Novosti. American medical scientists led by Charles Hennekens, the researcher who was the first in the world to discover the preventive properties of aspirin for people with a predisposition to cardiovascular disease, published updated recommendations for the use of this drug in the American Journal of Medicine.

The authors attribute the need for such a publication to the fact that recently a number of conflicting conclusions have appeared regarding the use of aspirin in the prevention of cardiovascular diseases. Some recommend using aspirin for people aged 40 to 70, who are at higher risk of a first heart attack or stroke, while others suggest that those over 70 can also use the drug.

In the past year, three large-scale trials of aspirin for primary prevention have been published in the United States, one of which showed a specific positive effect of the drug, while the other two did not show a clear result. As a result, doctors do not understand whether aspirin should be given for the primary prevention of heart attacks and strokes, and if so, to whom.

In a new article, American scientists insist that aspirin is effective in the treatment of cardiovascular disease, but for primary prevention it must be used with caution. To achieve maximum benefit, healthcare professionals must make individual clinical decisions on a case-by-case basis.

The article’s authors include Charles Hennekens of Florida Atlantic University’s Schmidt College of Medicine, a leading scientist in the field who was the world’s third most cited medical researcher from 1995 to 2005; David DeMets, professor at the University of Wisconsin, and Marc Pfeffer, MD, professor of medicine at Harvard Medical School.

The doctor spoke about the dangers of aspirin

July 25, 2019, 5:33 pm

“In the event of an acute heart attack, all patients should receive 325 milligrams of regular aspirin immediately and daily after the event to reduce the risk of sudden death,” Charles Hennekens said in a Florida Atlantic University press release. “In addition, after heart attacks and strokes, aspirin should be given long-term unless there are specific contraindications. However, the balance of absolute benefits of aspirin is lower in primary prevention than in secondary prevention.”

Researchers emphasize that when prescribing long-term aspirin therapy to healthy people, each time one should proceed from the specific situation and characteristics of the body, primarily blood clotting, in order to eliminate the risk of bleeding. But more important for primary prevention, from the point of view of scientists, is a healthy lifestyle, including smoking cessation, weight loss and increased daily physical activity, as well as proven drug therapy that has proven effective and confirmed by the attending physician.