How many Pepcid can you take in a day. What are the recommended dosages for different conditions. What are the side effects and interactions of Pepcid AC. How should Pepcid be administered.

Understanding Pepcid AC and Its Uses

Pepcid AC is a brand name for the drug famotidine, which belongs to a class of medications called histamine-2 (H2) blockers. These drugs work by reducing the amount of acid produced in the stomach. Pepcid AC is commonly used to treat various gastrointestinal conditions and provide relief from acid-related discomfort.

What conditions does Pepcid AC treat?

Pepcid AC is used to treat several conditions related to excess stomach acid, including:

• Active duodenal ulcers
• Active gastric ulcers
• Symptomatic nonerosive gastroesophageal reflux disease (GERD)
• Erosive esophagitis
• Pathological hypersecretory conditions
• Reduction of the risk of duodenal ulcer recurrence

Recommended Dosages of Pepcid AC

The dosage of Pepcid AC varies depending on the condition being treated and the patient’s renal function. It’s crucial to follow the recommended dosage prescribed by a healthcare professional.

What is the standard dosage for adults with normal renal function?

For adults and pediatric patients weighing 40 kg or more with normal renal function, the recommended dosages are as follows:

• Active duodenal ulcer: 40 mg once daily or 20 mg twice daily for up to 8 weeks
• Active gastric ulcer: 40 mg once daily for up to 8 weeks
• Symptomatic nonerosive GERD: 20 mg twice daily for up to 6 weeks
• Erosive esophagitis: 20 mg or 40 mg twice daily for up to 12 weeks
• Pathological hypersecretory conditions: Starting dosage of 20 mg every 6 hours, adjusted as needed (maximum 160 mg every 6 hours)
• Reduction of duodenal ulcer recurrence risk: 20 mg once daily for 1 year or as clinically indicated

How should the dosage be adjusted for patients with renal impairment?

For patients with moderate to severe renal impairment (creatinine clearance less than 60 mL/min), dosage adjustments are necessary. The recommended maximum dosages vary based on the severity of renal impairment and the condition being treated. For instance:

• For creatinine clearance 30-60 mL/min: Dosages range from 20 mg once daily to 40 mg every other day, depending on the condition
• For creatinine clearance less than 30 mL/min: Dosages are generally reduced to 20 mg every other day or 10 mg once daily

It’s important to note that for pathological hypersecretory conditions, use of Pepcid AC should be avoided in patients with severe renal impairment due to the risk of increased adverse reactions.

Administration Guidelines for Pepcid AC

Proper administration of Pepcid AC is crucial for its effectiveness and safety. Here are some important guidelines to follow:

When and how should Pepcid AC be taken?

Pepcid AC can be taken in one of two ways:

1. Once daily before bedtime
2. Twice daily, in the morning and before bedtime

The medication can be taken with or without food, as it does not significantly affect its absorption or efficacy.

Side Effects and Precautions of Pepcid AC

While Pepcid AC is generally well-tolerated, it’s important to be aware of potential side effects and take necessary precautions.

What are the common side effects of Pepcid AC?

Common side effects of Pepcid AC may include:

• Headache
• Dizziness
• Constipation or diarrhea
• Nausea and vomiting
• Dry mouth
• Fatigue

While these side effects are usually mild and transient, it’s important to consult a healthcare provider if they persist or worsen.

Are there any serious side effects to be aware of?

Although rare, some serious side effects may occur with Pepcid AC use. These can include:

• Severe allergic reactions (anaphylaxis)
• Liver problems
• Changes in heart rhythm
• Nervous system disorders

If you experience any severe or unusual symptoms while taking Pepcid AC, seek medical attention immediately.

Drug Interactions with Pepcid AC

Pepcid AC can interact with various medications, potentially affecting their efficacy or increasing the risk of side effects.

Which medications may interact with Pepcid AC?

Some medications that may interact with Pepcid AC include:

• Atazanavir and other HIV medications
• Metformin
• Warfarin
• Tizanidine
• Certain antifungal medications

It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking before starting Pepcid AC.

Special Considerations for Pepcid AC Use

Certain populations may require special considerations when using Pepcid AC.

Is Pepcid AC safe for use during pregnancy and breastfeeding?

While Pepcid AC is generally considered safe during pregnancy and breastfeeding, it’s important to consult with a healthcare provider before use. The benefits of treatment should be weighed against potential risks.

Can children take Pepcid AC?

Pepcid AC can be used in pediatric patients weighing 40 kg or more. However, for children weighing less than 40 kg, other formulations of famotidine may be more appropriate. The safety and effectiveness of Pepcid AC for certain conditions, such as the reduction of duodenal ulcer recurrence risk, have not been established in pediatric patients.

Long-term Use and Monitoring

For some conditions, long-term use of Pepcid AC may be necessary. However, it’s important to understand the implications of extended use and the need for monitoring.

What should be considered for long-term use of Pepcid AC?

Long-term use of Pepcid AC may be recommended for certain conditions, such as the reduction of duodenal ulcer recurrence risk. In such cases, regular monitoring by a healthcare provider is essential. This may include:

• Periodic assessment of symptoms and treatment efficacy
• Monitoring of renal function, especially in patients with kidney impairment
• Regular check-ups to evaluate the ongoing need for treatment

It’s important to note that while Pepcid AC can effectively manage acid-related conditions, it does not address underlying causes. Therefore, lifestyle modifications and addressing root causes should be part of a comprehensive treatment plan.

Are there any risks associated with long-term use of Pepcid AC?

While Pepcid AC is generally well-tolerated, long-term use may be associated with certain risks:

• Increased risk of certain infections due to reduced stomach acid
• Potential for vitamin B12 deficiency
• Possible increased risk of bone fractures, especially in older adults

These risks underscore the importance of regular monitoring and reassessment of treatment needs when using Pepcid AC for extended periods.

Pepcid Dosage Guide – Drugs.com

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Generic name: FAMOTIDINE 20mg
Dosage form: tablet, film coated
Drug class: h3 antagonists

Medically reviewed by Drugs.com. Last updated on Oct 24, 2022.

Recommended Dosage

Table 1 shows the recommended dosage of PEPCID 20 mg and 40 mg tablets in adult and pediatric patients weighing 40 kg and greater with normal renal function. The use of PEPCID 20 mg and 40 mg tablets is not recommended in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Use another famotidine formulation for pediatric patients weighing less than 40 kg.

Dosage in Renal Impairment

Dosage adjustments of PEPCID are recommended for patients with moderate to severe renal impairment (creatinine clearance less than 60 mL/min) [see Use in Specific Populations (8. 6)]. Table 2 shows the recommended maximum dosage of PEPCID 20 mg or 40 mg tablets for patients with renal impairment, by indication. Use the lowest effective dose. Some dosage adjustments may require switching to other formulations of famotidine (e.g., oral suspension, lower dose tablet).

Administration Instructions

•

Take PEPCID once daily before bedtime or twice daily in the morning and before bedtime, as recommended.

•

PEPCID may be taken with or without food [see Clinical Pharmacology (12.3)].

PEPCID may be given with antacids.

Frequently asked questions

• Is famotidine safer than omeprazole for heartburn?
• Can you take famotidine long term?
• Can I take omeprazole in the morning and famotidine at night?

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• Erosive Esophagitis
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Medical Disclaimer

Side effects, dosage, uses, and more

1. Prescription famotidine oral tablet is available as a generic drug and as a brand-name drug. Brand name: Pepcid.
2. Prescription famotidine also comes as a liquid suspension you take by mouth, and in an injectable form that’s only given by a healthcare provider. Famotidine also comes in over-the-counter forms.
3. Famotidine oral tablet is used to relieve symptoms of acid reflux and heartburn. It does this by reducing the amount of acid in your stomach.

Prescription famotidine oral tablet is available as a generic drug and as a brand-name drug. The brand name is Pepcid. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Prescription famotidine is also available as an oral suspension and an injectable form, which is only given by a healthcare provider. Famotidine also comes as an over-the-counter (OTC) drug. It comes as an OTC oral tablet and an OTC chewable oral tablet. This article focuses on the prescription oral tablet.

Why it’s used

Famotidine is used to relieve symptoms of acid reflux and heartburn. It does this by reducing the amount of acid in your stomach. It treats the following conditions:

• Gastroesophageal reflux disease (GERD). GERD happens when acid in your stomach backs up into your esophagus (the tube that connects your mouth to your stomach). This may cause a burning feeling in your chest or throat, a sour taste in your mouth, or burping.
• Acid-related damage to the lining of your esophagus. When stomach acid splashes up and into the lower portion of your esophagus, it can cause damage to the tissue cells in your esophagus.
• Duodenal ulcers. The duodenal area is the part of your intestine where food passes when it leaves the stomach.
• Stomach ulcers. Also known as gastric ulcers, these are painful sores in the stomach lining.
• Conditions where your stomach makes too much acid. These conditions include Zollinger-Ellison syndrome.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

How it works

Famotidine belongs to a class of drugs called histamine-2 receptor blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Famotidine works by blocking the histamine 2 (h3) receptor in your stomach. This receptor helps release acid in your stomach. By blocking this receptor, this drug lowers the amount of acid released in your stomach.

Famotidine oral tablet can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking famotidine. This list does not include all possible side effects.

For more information on the possible side effects of famotidine, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.

More common side effects

The more common adult side effects for this drug are slightly different from the more common side effects for children.

• Adult side effects can include:
  • headache
  • dizziness
  • constipation
  • diarrhea
• Children under one year of age may also experience:
  • agitation, unusual restlessness, or crying for no clear reason

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Heart rate and rhythm problems. Symptoms can include:
  • dizziness
  • fainting
  • shortness of breath
  • irregular heart rate and rhythm
• Severe muscle problems. Symptoms can include:
  • unusual muscle pain that you cannot explain
  • weakness
  • fever
• Neurological problems. Symptoms can include:
  • agitation
  • anxiety
  • depression
  • trouble sleeping
  • seizures
  • sexual problems, such as decreased sex drive
• Liver problems. Symptoms can include:
  • unexplained or unusual weakness
  • decrease in appetite
  • pain in your abdomen (stomach area)
  • change in the color of your urine
  • yellowing of your skin or the whites of your eyes
• Skin problems. Symptoms can include:
  • blisters
  • rash
  • mouth sores or ulcers

Famotidine oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Before taking famotidine, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

The famotidine dosage your doctor prescribes will depend on several factors. These include:

• the type and severity of the condition you’re using famotidine to treat
• your age
• the form of famotidine you take
• other medical conditions you may have

Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Forms and strengths

Generic: Famotidine

• Form: oral tablet
• Strengths: 20 mg, 40 mg

Brand: Pepcid

• Form: oral tablet
• Strengths: 20 mg, 40 mg

Dosage for duodenal ulcer

Adult dosage (ages 18 years and older)

• Short-term dosage: 40 mg taken once per day at bedtime for up to eight weeks. Your doctor may divide your dose into 20 mg taken two times per day.
• Long-term dosage: 20 mg taken once per day at bedtime.

Child dosage (ages 0–17 years, 40 kg [88 lbs.] or greater)

• Short-term dosage: 40 mg taken once per day at bedtime for up to eight weeks. Your doctor may divide your dose into 20 mg taken two times per day.
• Long-term dosage: 20 mg taken once per day at bedtime.
• Dosage changes: Your doctor may adjust your dosage and length of treatment based on how well you respond to the drug.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

People with moderate or severe kidney disease: Your doctor may decrease your dose of this drug by half or they may have you take one dose every 48 hours instead of every day.

Dosage for gastric ulcer

Adult dosage (ages 18 years and older)

• Short-term dosage: 40 mg taken once per day at bedtime for up to eight weeks.

Child dosage (ages 0–17 years, 40 kg [88 lbs.] or greater)

• Short-term dosage: 40 mg taken once per day at bedtime for up to eight weeks.
• Dosage changes: Your doctor may adjust your dosage and length of treatment based on how well you respond to the drug.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

People with moderate or severe kidney disease: Your doctor may decrease your dose of this drug by half. Or they may have you take one dose 48 hours instead of every day.

Dosage for gastroesophageal reflux disease

Adult dosage (ages 18 years and older)

• Gastroesophageal reflux disease (GERD) symptoms: 20 mg taken two times per day for up to six weeks.
• Esophagitis (irritated esophagus with sores) with GERD symptoms: 20 to 40 mg taken two times per day for up to 12 weeks.

Child dosage (ages 0–17 years, 40 kg [88 lbs. ] or greater)

• Gastroesophageal reflux disease (GERD) symptoms: 20 mg taken two times per day for up to six weeks.
• Esophagitis (irritated esophagus with sores) with GERD symptoms: 20 to 40 mg taken two times per day for up to 12 weeks.
• Dosage changes: Your doctor may adjust your dosage and length of treatment based on how well you respond to the drug.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

People with moderate or severe kidney disease: Your doctor may decrease your dose of this drug by half. Or they may have you take one dose every 48 hours instead of every day.

Dosage for pathological hypersecretory conditions

Adult dosage (ages 18 years and older)

• Typical starting dose: 20 mg taken every 6 hours.
• Dose increases: Your doctor may increase your dose based on your symptoms.
• Maximum dose: People with severe disease may need 160 mg taken every 6 hours.

Child dosage (under 0–17 years)

This drug hasn’t been studied in children under 18 years of age for the treatment of this condition.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

People with moderate or severe kidney disease: Avoid using famotidine tablets for treating pathological hypersecretory conditions. The doses required for treating this condition may be higher than the maximum doses recommended in people with kidney disease.

Famotidine oral tablet comes with several warnings.

Allergy warning

Famotidine can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling in your eye(s) or face
• swelling of your throat or tongue
• rash
• hives

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or other histamine receptor blockers (such as cimetidine, ranitidine, or nizatidine). Taking it again could be fatal (cause death).

Ranitidine, brand name Zantac, is now marketed as Zantac 360, which contains a different active ingredient (famotidine). Famotidine is in the same class as ranitidine and works the same way but has not been found to contain unacceptable levels of NDMA.

Warnings for people with certain health conditions

For people with moderate or severe kidney disease: If you have kidney problems, you may not be able to clear this drug from your body. This may increase the levels of this drug in your body. The increased levels may cause more side effects, such as confusion and an irregular heart rhythm called QT prolongation.

Warnings for other groups

For pregnant women: There haven’t been enough studies done in humans to show if famotidine poses a risk to a human fetus. Research in animals has not shown a risk to the fetus when the mother takes the drug. However, animal studies don’t always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.

For women who are breastfeeding: Famotidine may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

For children:

• Famotidine may be used in children with peptic ulcer disease (such as duodenal or gastric ulcer) and gastroesophageal reflux disease (GERD).
• This drug hasn’t been studied in children under 18 years of age for the treatment of pathological hypersecretory conditions or reducing the risk of duodenal ulcer recurrence.
• Famotidine tablets are not recommended for use in children weighing less than 40 kg (88 lbs.). This is because the strengths of these tablets are greater than the recommended dose for these children. For these children, consider using another form of famotidine (such as the oral suspension).

Famotidine oral tablet is used for long-term treatment of Zollinger-Ellison syndrome and maintaining healing of ulcers. Famotidine oral tablet is used for short-term treatment of gastroesophageal reflux disease (GERD) and duodenal and gastric ulcers. Famotidine comes with risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your acid reflux, heartburn, or ulcer symptoms may not get better or may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• agitation
• confusion
• seizures
• severe muscle pain

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: You should have less pain and your symptoms should improve.

Keep these considerations in mind if your doctor prescribes famotidine oral tablet for you.

General

• You can take famotidine with or without food.
• Take this drug at the time(s) recommended by your doctor.
• You can cut or crush the tablet.
• Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Storage

Store the oral tablets at 77°F (25°C). They may be stored for a short time from 59°F to 86°F (15°C to 30°C). Keep them away from light.Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Your diet

Certain foods and beverages may irritate your stomach. This irritation could make your symptoms worse. Your doctor may suggest that you avoid spicy, acidic, and fatty foods while you take this drug. (Acidic foods include tomatoes and citrus fruits.) They may also ask you to avoid beverages with caffeine.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

film-coated tablets, lyophilisate for solution for intravenous administration, 20 mg, 40 mg

film-coated tablets 20 mg blister pack, 40 mg blister pack —
In a dry, dark place, at a temperature not exceeding 25 °C.
film-coated tablets 40 mg blister, 20 mg blister —
At a temperature not exceeding 25 ° C, in the original packaging (in a pack).
film-coated tablets 40 mg blister pack, 20 mg blister pack —
In a place protected from light, at a temperature not exceeding 25 ° C.
film-coated tablets 20 mg blister pack —
At a temperature not higher than 25 °C.

Keep out of reach of children.

film-coated tablets 20 mg blister pack, 40 mg blister pack – 3 years.
film-coated tablets 40 mg blister pack, 20 mg blister pack – 4 years.

Do not use after the expiry date which is stated on the packaging.

White to pale yellow crystalline compound, readily soluble in glacial (anhydrous) acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Molecular weight 337.43 Da.

Mechanism of action

Famotidine is a competitive inhibitor of H ₂ histamine receptors. The main clinically important pharmacological action of famotidine is the inhibition of gastric secretion. Famotidine suppresses both the concentration of acid and the volume of gastric secretion, while changes in pepsin secretion are proportional to its volume.

Pharmacodynamics

adults

Famotids inhibits both basal and nightstock secretion, as well as secretion stimulated by food and pentagastine. After oral administration, the antisecretory effect occurs within 1 hour, the maximum effect depends on the dose and occurs within 1-3 hours. The duration of secretion inhibition with doses of 20 and 40 mg is from 10 to 12 hours.

Single evening oral doses of 20 and 40 mg suppressed basal and nocturnal gastric acid secretion in all patients, mean nocturnal gastric acid secretion was suppressed by 86 and 94%, respectively, for a period of at least 10 hours. Famotidine at the same doses (20 and 40 mg ) taken in the morning suppressed food-stimulated acid secretion in all patients. The average level of suppression of acid secretion was 76 and 84%, respectively, 3-5 hours after administration and 25 and 30%, respectively, 8-10 hours after administration. However, in some patients treated with famotidine at a dose of 20 mg, the antisecretory effect subsided within 6-8 hours. No cumulative effect was observed with multiple doses. Evening administration of famotidine at doses of 20 and 40 mg increased the nocturnal intragastric pH to mean values ​​of 5 and 6.4, respectively. Administration of famotidine at doses of 20 and 40 mg in the morning after a meal increased the daily basal intragastric pH to approximately 5 at 3 and 8 hours after administration.

Taking famotidine in the morning on an empty stomach or after a meal had virtually no effect on serum gastrin levels. Famotidine did not affect gastric emptying and exocrine pancreatic function.

In studies of clinical pharmacology of famotidine, no systemic effects on the central nervous system, cardiovascular system, respiratory or endocrine systems were noted. No antiandrogenic effects were also noted. Serum hormone levels, including prolactin, cortisol, thyroxine (T ₄ ) and testosterone, did not change after oral administration of famotidine.

Children

The pharmacodynamics of famotidine based on gastric pH was evaluated in 5 patients aged 2 to 13 years using a sigmoid model E _max . The data obtained indicate that the relationship between the concentration of famotidine in the blood serum and the suppression of gastric acidity is similar to that observed in adults (see table 1).

Table 1

Serum concentrations of famotidine associated with decreased gastric acidity in children and adults treated with famotidine

¹ Using the sigmoid curve for determining E 9 0033 max famotidine serum concentrations at which decrease in gastric acidity by 50% of the maximum, are presented as mean values ​​± standard deviation.

In a study of the effect of famotidine on gastric pH and duration of acid suppression in children in 4 patients aged 11 to 15 years who took oral famotidine at a dose of 0.5 mg/kg, gastric pH remained above 5 for (13.5 ±1.8) h. The bioavailability of oral doses is 40-45%. Bioavailability may be slightly increased by food intake or slightly decreased by antacids, but these effects are not of clinical significance.

T _max famotidine in plasma is 1-3 hours. Plasma concentration after multiple doses is similar to that after a single dose.

Distribution

From 15 to 20% of famotidine binds to plasma proteins.

Metabolism

Famotidine undergoes minimal first pass metabolism. From 25 to 30% of the oral dose is excreted in the urine as unchanged compound. The only metabolite identified in humans is S-oxide.

Elimination of

T _1/2 famotidine is 2.5–3.5 hours. Famotidine is eliminated by the renal (65–70%) and metabolic (30–35%) routes. Renal clearance is 250-450 ml/min, indicating some tubular secretion.

Special patient groups

Children. Bioavailability studies in 8 patients aged 11 to 15 years showed a mean oral bioavailability of 0.5 compared to adult values ​​of 0.42-0.49. In children aged 11 to 15 years, the AUC was (580 ± 60) ng h/mL with famotidine 0.5 mg/kg orally, compared with (482 ± 181) ng h/mL in adults treated with 40 mg famotidine orally.

Renal insufficiency. In adult patients with severely impaired renal function (Cl creatinine <30 ml / min), the AUC of famotidine increased at least 5 times. In patients with moderate renal impairment (Cl creatinine 30-60 ml / min), the AUC of famotidine increased at least 2-fold (see "Precautions").

Drug interaction studies

Organic anion transporter 1 and 3 (OAT1 and OAT3). In vitro studies”> in vitro showed that famotidine is a substrate of OAT1 and OAT3. After co-administration of probenecid (1500 mg), an inhibitor of OAT1 and OAT3, and 20 mg of famotidine in 8 healthy volunteers AUC _0-10 famotidine in serum increased from 424 to 768 ng h / ml, and C _max from 73 to 113 ng / ml. Renal clearance, urinary excretion rate and the amount of famotidine excreted unchanged in the urine were reduced. Clinical significance this interaction is unknown.0014

Multiple drug and toxin transporter (MATE1). In vitro study”> in vitro showed that famotidine is an inhibitor of MATE1. However, no clinically significant interaction with metformin, a substrate of MATE1, was observed.

CYP1A2. Famotidine is a weak inhibitor of CYP1A2.

9 0024 Carcinogenicity, mutagenicity , effects on fertility

The carcinogenic potential of famotidine was evaluated in a 106-week oral study in rats and 92-week oral study in mice. In a 106-week study in rats and a 92-week study in mice at oral doses up to 2000 mg/kg/day (approximately 243 and 122 times the recommended human dose (80 mg/day) in the treatment of erosive esophagitis, based on area body surface), there was no evidence of the carcinogenic potential of famotidine.

Famotidine was negative in the mutagenic activity test (Ames test) using Salmonella typhimurium and Escherichia coli with or without activation of rat liver enzymes at concentrations up to 10,000 µg/dish (Petri). No evidence of mutagenic potential of famotidine was found in in vivo”> ​​ in vivo mice in mouse lymphoma cell micronucleus and chromosome aberration tests.

243 times the recommended human dose (80 mg/day) based on body surface area), famotidine had no effect on fertility or reproductive function.

Clinical studies

Active duodenal ulcer colon, famotidine was compared with oral placebo. As shown in Table 2, 70% of patients treated with famotidine 40 mg at night were cured by week 4. In most patients, complete healing of duodenal ulcers occurred within 4 weeks.

Patients who were not cured by week 4 remained in the study. By week 8, healing of duodenal ulcers occurred in 83% of patients treated with famotidine compared with 45% of patients treated with placebo. The frequency of healing of duodenal ulcers with famotidine was higher than with placebo at each time point, based on the proportion of endoscopically confirmed healing of duodenal ulcers. The study did not evaluate the safety of taking famotidine for more than 8 weeks of uncomplicated active duodenal ulcer.

Table 2

Patients with endoscopically confirmed healing of duodenal ulcers ¹

900 70

¹ p<0.001 vs. placebo.

In this study, the time to resolution of daytime and nighttime pain was shorter in patients treated with famotidine compared with those treated with placebo. Patients who received famotidine also took fewer antacids compared with patients who received placebo.

Active gastric ulcer

In both US and international multicentre, double-blind studies in patients with endoscopically confirmed active gastric ulcer, oral famotidine 40 mg at night was compared with placebo. During the studies, antacids were allowed, but their use did not show significant differences between the famotidine and placebo groups.

As shown in Table 3, endoscopy-proven gastric ulcer healing rates (patients with unhealed gastric ulcers were considered dropouts) were higher with famotidine than with placebo at weeks 6 and 8 in a US study , and at 4, 6 and 8 weeks in an international study. In these studies, most patients treated with famotidine were cured within 6 weeks. Studies have not evaluated the safety of taking famotidine for more than 8 weeks of uncomplicated active gastric ulcer.

Table 3

Patients with endoscopically confirmed healing of gastric ulcers

1 p≤0. 01 vs placebo.

² p≤0.05 vs. placebo.

The time to complete resolution of daytime and nighttime pain was statistically significantly shorter in patients treated with famotidine tablets compared with patients treated with placebo, but no study showed a statistically significant difference in the proportion of patients who experienced pain relief by the end of the study (by the 8th week).

Symptomatic GERD

In a US study in patients with symptomatic GERD and no endoscopic evidence of esophageal erosion or ulceration, oral famotidine was compared with placebo. As shown in Table 4, patients treated with famotidine 20 mg twice daily experienced a greater improvement in GERD symptoms than those treated with famotidine 40 mg at night or placebo.

Table 4

Patients with improvement in GERD symptoms (n=376)

¹ p≤0. 01 vs placebo.

Erosive esophagitis due to GERD

Healing of endoscopically confirmed erosions and improvement in symptoms was studied in a US and international double-blind study. Healing was defined as complete resolution of all erosions seen on endoscopy. In a US study comparing oral famotidine 40 mg twice daily with placebo and oral famotidine 20 mg twice daily, there was a significantly greater percentage of healing of erosive esophagitis at weeks 6 and 12 (table 5).

Table 5

Patients with endoscopically confirmed healing of erosive esophagitis in the US study (n=318)

¹ p≤0. 01 vs. Pla cebo.

² p≤0.01 compared with famotidine 20 mg twice daily.

³ p≤0.05 compared with famotidine 20 mg twice daily.

In a US study, patients treated with famotidine experienced faster resolution of daytime and nocturnal heartburn, and a greater proportion of patients experienced complete resolution of nocturnal heartburn compared with placebo. These differences were assessed as statistically significant.

In an international study comparing oral famotidine 40 mg twice daily with oral ranitidine 150 mg twice daily, there was a statistically significantly higher percentage of healing of erosive esophagitis when taking famotidine at week 12 (Table 6) . However, there were no significant differences in symptom relief between treatment groups.

Table 6

Patients with endoscopically confirmed healing of erosive esophagitis in an international study (n=440)

^{≤0. 05 compared to ranitidine 150 mg twice daily.}

Pathological hypersecretory conditions

In studies involving patients with pathological hypersecretory conditions such as Zollinger-Ellison syndrome with or without multiple endocrine neoplasms, famotidine significantly suppressed gastric acid secretion and controlled associated symptoms. Oral famotidine at a dose of 20 to 160 mg every 6 hours maintained basal acid secretion below 10 mEq/h, initial doses were titrated according to individual needs, followed by dose adjustment during therapy in some patients.

Reduced risk of duodenal ulcer recurrence

Two randomized, double-blind, multicenter trials in patients with endoscopically confirmed complete healing of duodenal ulcer showed a reduction in duodenal ulcer recurrence in patients receiving oral famotidine at doses of e 20 mg at night, compared with placebo.

In a US study, recurrence of duodenal ulcer within 12 months was 2.4 times more common in patients treated with placebo than in patients treated with famotidine. 89In patients treated with famotidine, the cumulative observed rate of recurrence of duodenal ulcer was 23% compared with 57% in 89 patients treated with placebo (p < 0.01).

In an international study, the cumulative observed 12-month recurrence rate of duodenal ulcer in 307 patients treated with famotidine was 36% compared with 76% in 325 patients treated with placebo (p<0.01).

The duration of controlled studies did not exceed 1 year.

History of hypersensitivity (eg, anaphylaxis) to famotidine or other H ₂ receptor antagonists.

Clinical study experience

Because clinical studies are conducted in a variety of settings, the frequency of adverse reactions observed in one clinical study cannot be directly compared with the frequency observed in another clinical study and may not reflect the frequency observed in practice.

A total of 1442 patients were treated with famotidine, including 302 patients – 40 mg 2 times a day, 456 patients – 20 mg 2 times a day, 461 patients – 40 mg 1 time per day and 396 patients – 20 mg 1 time per day. Patient age ranged from 17 years to 91 years, patients were quite well distributed by gender and race, however, the Caucasian race predominated.

In these studies, the following adverse reactions were reported with a frequency of ≥1%: headache, dizziness and constipation.

The following adverse reactions have been reported with a frequency of <1%.

On the part of the body as a whole: increased body temperature (fever), asthenia, fatigue.

From the side of the CCC: palpitations.

From the gastrointestinal tract: increased levels of liver enzymes, vomiting, nausea, abdominal discomfort, anorexia, dry mouth.

Blood side: thrombocytopenia.

Hypersensitivity reactions: eye oedema (swelling of the orbital tissues), rash, conjunctival injection, bronchospasm.

From the musculoskeletal system: musculoskeletal pain, arthralgia.

From the side of the nervous system / mental disorders: convulsions, hallucinations, depression, anxiety, decreased libido, insomnia, drowsiness.

Skin: skin itching, dry skin, redness.

From the senses: tinnitus, taste disorders.

Other: impotence.

Post-registration observations

The following adverse reactions have been reported in the post-registration period of famotidine use. Since data on these reactions are obtained from spontaneous reports from an indeterminate population, it is not possible to reliably estimate their frequency or establish a causal relationship with famotidine exposure.

From the side of the CCC: arrhythmia, AV blockade, prolongation of the QT interval.

From the gastrointestinal tract: cholestatic jaundice, hepatitis.

Blood disorders: agranulocytosis, pancytopenia, leukopenia.

Hypersensitivity reactions: anaphylaxis, angioedema, facial edema, urticaria.

From the musculoskeletal system: rhabdomyolysis, muscle cramps.

From the side of the nervous system / mental disorders: confusion, agitation, paresthesia.

From the respiratory system: interstitial pneumonia.

Skin disorders: toxic epidermal necrolysis/Stevens-Johnson syndrome.

Oral, once a day at night or twice a day – in the morning and at night, can be taken on an empty stomach or with meals. The dosage regimen and duration of treatment depend on the disease, the status of the patient and are determined by the attending physician.

How much Pepcid AC can I give my dog?

Contents

The usual dose of famotidine for dogs is 0.25 mg to 0.5 mg per pound of body weight twice daily. Some forms of the drug are available without a prescription, but you should not give it to your dog without veterinary approval.

Can I give my dog ​​Pepcid AC 20mg?

Pepsid is one of 15 over-the-counter human drugs that are considered safe for dogs.

How many mg of Pepcid can I give my dog?

Tablets are available in 10, 20 and 40 mg doses and the powder must be measured for correct dosage. The recommended dosage is often 0.22 to 0.44 mg per pound of dog weight. The drug does not require a prescription, but the drug should still be administered on the advice of a licensed veterinarian.

What does Pepcid AC do for dogs?

Pepcid® is the brand name for famotidine, an antihistamine that treats stomach ulcers and other chronic gastrointestinal conditions. Although designed for human use, Pepcid® is generally recommended by veterinarians for the treatment of gastrointestinal symptoms associated with excess stomach acid.

How quickly does Pepcid AC work on dogs?

This medicine should work within 1-2 hours; however, the effects may not be noticeable and your veterinarian may need to run lab tests to evaluate if the medication is working.

How much Pepcid can a 70 lb dog take?

The usual dose of famotidine for dogs is 0. 25 mg to 0.5 mg per pound of body weight twice daily.

Can dogs take human famotidine?

All about famotidine for dogs and cats

Most commonly used to treat heartburn and ulcers in both humans and dogs. Famotidine is widely used in human and veterinary medicines due to its improved mechanism of action and duration of action compared to other drugs in this class.

How much Pepcid AC do you give a 10 lb dog?

Never exceed half a milligram (0.5 mg) per pound of dog body weight. The agreed dosage for Pepcid AC is 0.25mg to 0.5mg (1 half) per pound once or twice a day.

What is the best antacid for dogs?

Omeprazole (brand names Gastrogard® and Prilosec®) is used to treat ulcers that occur in the stomach and upper small intestine in dogs and cats. It is also used to treat or prevent gastric erosions caused by medications such as non-steroidal anti-inflammatory drugs (NSAIDs).

Can I give my dog ​​Pepcid every day?

In conclusion, these results suggest that famotidine loses its effectiveness as an acid suppressant over time when administered twice daily to dogs. Therefore, caution is advised in recommending long-term oral administration of famotidine to dogs.

Can Pepcid AC be cut in half?

General. You can take famotidine with or without food. Take this drug at the time recommended by your doctor. The tablet can be cut or crushed.

Can a dog overdose famotidine?

Famotidine overdose is rare, but overdose symptoms may include: Vomiting. Anxiety. Redness of the mouth and ears.

How many antacids can I give my dog?

The dose most commonly used in dogs as an antacid is 0.5 grams and up to 5 grams total dose orally every 4 hours as needed. Small dogs may receive 500 mg, medium-sized dogs 750 to 1000 mg, and larger dogs 2000 mg.

Can I give my dog ​​famotidine for an upset stomach?

If your dog has gas, you can use Famotidine, the generic version of pepsid for dogs! Famotidine for Dogs 20mg is used to relieve various medical problems such as stomach inflammation, acid reflux and more! This easy-to-use formula provides long-lasting relief for your stressed pets!

What can I give my dog ​​for acid reflux at home?

7 tricks to help your dog with GERD

• Fresh ginger. My chiropractor suggested trying ginger once a day for pebbles as it helps people with the same condition.
• Slippery Elm.
• Pre- and probiotics.
• Digestive enzymes.
• More frequent meals.
• Sleep with raised head.
• Chiropractic adjustments.

How much Pepcid can I give my 80 lb dog?

Recommended dosage

The dosage of famotidine most commonly recommended for dogs is 0.25 to 0.5 mg/lb twice daily.

When should I give my dog ​​famotidine?

Famotidine may also be prescribed to treat symptoms associated with the following conditions:

1. Acid reflux.
2. Canine parvovirus.
3. Inflammatory bowel disease.
4. Ulcers of the stomach and intestines.
5. Ingestion of ulcerative toxin.
6. Inflammation of the gastric mucosa.
7. Inflammation or enlargement of the esophagus.

What is the difference between PEPCID and Pepcid AC?

Original Strength PEPCID AC ^® and Ultimate Strength PEPCID AC ^® contain an h3 blocker that starts working in 15-30 minutes and helps control acidity all day or all night. * PEPCID Complete ^® combines an h3 blocker with an antacid that neutralizes stomach acid in seconds, so it works even faster.

Can you cut 20 mg of PEPCID in half?

General. You can take famotidine with or without food. Take this drug at the time recommended by your doctor. The tablet can be cut or crushed.

Is Pepcid AC the same as Pepcid Complete?

Pepcid AC is an OTC product containing only famotidine. Famotidine Complete (Pepcid Complete) is a combination of famotidine and two antacids: calcium carbonate and magnesium hydroxide.

What can I give my dog ​​for indigestion without a prescription?

Antidiarrheals/Anti-nausea. Bismuth subsalicylate (Pepto-Bismol®) is commonly stocked in a first aid kit for indigestion and can be given to a dog.

What does acid reflux look like in dogs?

Mild gastroesophageal reflux usually presents with profuse salivation (drooling), regurgitation, vomiting, belching, and bad breath. Dogs with gastric reflux often lick the air obsessively in an attempt to swallow the rising stomach fluid.

How do I know if my dog ​​has acid reflux?

Signs of acid reflux in dogs

1. Licking lips or trying to lick air.
2. Decreased appetite.
3. Vomiting of bile.
4. Grinding of teeth or snapping of the jaw.
5. Painful swallowing (they may cry or whine)
6. Regurgitation of food.
7. Weight loss.
8. Restlessness or signs of discomfort.

Why does my dog ​​vomit stomach acid?

When a dog vomits bile, it is a sign of a number of conditions affecting the digestive system, including inflammatory diseases, ulcers, parasitic infections, and some types of cancer. In each of these cases, the veterinarian must diagnose and treat the underlying condition in order to ease the vomiting.

How to calm a dog’s stomach?

Foods that can help calm an upset stomach and make your dog’s stool harder if he has diarrhea include:

1. Regular canned pumpkin.
2. Oatmeal.
3. Plain unsweetened yogurt.
4. Sweet potato.
5. Bananas.

What are the side effects of Pepcid AC?

What are the side effects of pepcid?

• constipation,
• diarrhea,
• fatigue,
• dizziness,
• weak spot,
• mood changes,
• Headache,
• insomnia,

How often can I take Pepsid AS 20 mg?

How to use Pepcid AC Maximum strength 20mg tablets for peptic ulcer. Take this medicine by mouth with or without food as directed by your doctor, usually once or twice a day. If you are taking this medication once a day, it is usually taken right before bed.

Why was PEPCID withdrawn?

The World Health Organization has classified this substance, N-nitrosodimethylamine (NDMA), as a “probable human carcinogen”. The FDA stated that Denton Pharma Inc. recalled several batches of unexpired ranitidine tablets due to the possible presence of NDMA.

Half a 20 mg tablet is 10 mg?

If you buy 20mg tablets, cut them in half and then take only half (now 10mg), you can double your purchasing power.

Does famotidine treat gastritis?

Acid blockers, also called histamine (H-2) blockers, reduce the amount of acid released into the digestive tract, which relieves gastritis pain and promotes healing. Acid blockers available by prescription or over the counter include famotidine (Pepcid), cimetidine (Tagamet HB), and nizatidine (Axid AR).

What is Pepsid 10 mg used for?

TRADE NAME(S): Pepcid AC. USE: Famotidine is known as a h3 histamine blocker. It works by reducing the amount of acid in the stomach. It is used to prevent and treat heartburn and other symptoms caused by excess acid in the stomach (acid indigestion).

How long does PEPCID 10 mg last?

The effect of famotidine lasts 10 to 12 hours after a single dose. Peak effects are reached within one to three hours after a dose. Relief of GERD symptoms occurs within 24 hours after the start of famotidine therapy.

How to give Pepsid to a dog?

How to give Pepcid to dogs: It is not recommended to give Pepcid with food as this may reduce its effectiveness. Instead, tilt your dog’s head back, place the tablet on the back of the tongue, close the mouth for a moment, and gently stroke the throat or blow on the nose to induce swallowing.

Does peanut butter help a dog with an upset stomach?

So, yes, most types of peanut butter are ideal for a healthy dog, but you should only give it as a treat in moderation. Some dogs get indigestion after eating a little or a lot of peanut butter. In most cases, the symptoms resolve quickly and you avoid re-feeding the food to your dog.

What quickly eliminates indigestion?

Home treatments for indigestion may include drinking small amounts of clear liquids, drinking plenty of water, small sips of water or sucking on ice cubes, sports drinks, clear sodas, diluted juices, clear broth or broth, popsicles, caffeine.