Excedrin Migraine (Acetaminophen, Aspirin, And Caffeine) – Side Effects, Interactions, Uses, Dosage, Warnings

uses

What is Excedrin Migraine (Oral) used for?

• Analgesic/Antipyretic

warnings

What is the most important information I should know about Excedrin Migraine (Oral)?

Do not give this medicine to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye’s syndrome, a serious and sometimes fatal condition in children.

You should not use this medicine if you are allergic to acetaminophen (Tylenol), aspirin, caffeine, or any NSAIDs (diclofenac, ibuprofen, indomethacin, meloxicam, naproxen, Advil, Aleve, Motrin, and others).

Aspirin may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking this medicine.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

• liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
• asthma or seasonal allergies;
• fever with a stiff neck;
• stomach ulcer, stomach or intestinal bleeding, ulcerative colitis;
• bleeding problems;
• kidney disease; or
• if you use medicine to treat glaucoma or prevent blood clots.

If you take acetaminophen, aspirin, and caffeine to treat headache pain, seek medical attention if you have:

• a headache so bad you have to lie down;
• a headache that causes vomiting;
• what feels like the worst headache you’ve ever had;
• a headache that seems different from your usual headaches;
• a headache every day;
• a headache after coughing, bending, exercising, or head injury;
• if you have never had migraines diagnosed by a doctor; or
• if you are having your first headache after age 50.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Ask a doctor before using this medicine if you are pregnant.

Do not give this medicine to anyone younger than 18 years old without medical advice.

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Side Effects

What are the side effects of Excedrin Migraine (Oral)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

• severe anxiety, agitation, confusion, panic;
• easy bruising or bleeding;
• a light-headed feeling, like you might pass out;
• dehydration symptoms–feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
• symptoms of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• high potassium–nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
• liver problems–nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• upset stomach, heartburn;
• depressed mood, feeling anxious or restless; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Excedrin Migraine (Oral) if I’m pregnant or breastfeeding?

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Ask a doctor before using this medicine if you are pregnant.

Interactions

What drugs and food should I avoid while taking Excedrin Migraine (Oral)?

Avoid drinking alcohol. It may increase your risk of liver damage or stomach bleeding.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to acetaminophen or aspirin (such as ibuprofen, ketoprofen, or naproxen).

Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

Dosage Guidelines & Tips

How to take Excedrin Migraine (Oral)?

Use Excedrin Migraine (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Excedrin Migraine (Oral)?

Since acetaminophen, aspirin, and caffeine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Excedrin Migraine (Oral)?

Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

Overdose symptoms may also include ringing in your ears, headache, diarrhea, hallucinations, fast or slow heart rate, or seizure (convulsions).

If you think you or someone else may have overdosed on: Excedrin Migraine (Oral),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Excedrin Migraine (Oral), call 911

911

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What to Know About Generic Excedrin® Migraine (Migraine Relief) | Cove

125rem” font-weight=”lighter”>If the recent Excedrin® Migraine shortage has you scrambling to find an alternative to your go-to over-the-counter migraine treatment, you’ve come to the right place. Here’s everything you need to know about the generic version of Excedrin® Migraine, fittingly named Migraine Relief.

Migraine Relief is a medication that’s actually a combination of two common pain relievers (aspirin and acetaminophen), along with caffeine. All three parts have been proven to reduce the pain of mild to moderate headaches including migraine. When they’re combined, they’re even more effective for headache pain relief than any one ingredient would be on its own.

Migraine Relief isn’t a prescription drug, so it’s available over-the-counter (OTC) without a prescription from your healthcare provider.

125rem” font-weight=”lighter”>Most people have aspirin or acetaminophen in their medicine cabinet and know that they’re effective pain relievers on their own—especially for minor aches and the occasional tension headaches. Acetaminophen is classified as a pain reliever and fever reducer, while aspirin is a pain reliever, fever reducer, and anti-inflammatory medication. As you might imagine, they become even more potent, effective, and fast when they’re combined.

However, it’s the caffeine ingredient that really helps those medications work their magic. Caffeine can act in a few different ways: as a mild blood vessel constrictor, a pain reliever, and as an agent that improves the absorption of other medications. In fact, studies have shown that when caffeine is added to the combination of aspirin and acetaminophen, the pain-relieving effect can increase up to 40%.

125rem” font-weight=”lighter”>Think you can just pop an aspirin, drink some coffee, and get the same result? Not quite. Migraine Relief actually has less caffeine than coffee (a standard cup of coffee can have as much as 134 mg of caffeine, while Migraine Relief has around 65 mg), but it’s the concentration of this ingredient that makes it so effective for migraine pain.

Migraine Relief comes in caplet form and should be taken with a full glass of water. Both acetaminophen and aspirin can cause mild stomach upset when taken on an empty stomach, so grab a snack while you’re at it. Refer to the product information on the packaging for any other specific directions, potential side effects, or questions about your first dose.

If you have a known allergy to any of Migraine Relief’s three ingredients, tell your doctor so that you can avoid an allergic reaction.

You should also tell your doctor if you have polyps in your nose and/or if you have ever experienced swelling of the mouth, lips, tongue, or throat, or difficulty breathing after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.

As always, it’s smart to inform your doctor of all of the medications that you’re currently taking, and let them know if you have bleeding problems or excessive bruising.

Tell your doctor if you’re pregnant, are planning to become pregnant, or are breastfeeding. Per the FDA, aspirin is generally not recommended during pregnancy.

Finally, you shouldn’t take this medication more than two days per week, as it can lead to medication overuse or rebound headaches, which are more difficult-to-treat conditions. If you have been taking this medication for more than two days each week on average, let your doctor know right away.

Yes, Migraine Relief is safe to take along with any preventive medications you might be using for your migraine headaches, as well as many of the medications used to treat an acute migraine attack. However, you should not take Migraine Relief if you are already taking aspirin, acetaminophen, or other NSAIDs on their own.

Your Migraine Relief should be stored in a dry place at room temperature.

Aspirin and acetaminophen can be used individually to relieve mild to moderate headaches. You can also use sumatriptan and other NSAIDs (such as ibuprofen, naproxen, and others).

As the name implies, Migraine Relief is most commonly taken for migraine attacks. It can also be taken for tension-type headaches, as long as it’s not taken more than two days per week on average.

The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your doctor.

Naproxen is an oral medication used to ease pain, swelling, and fever. This drug may raise the chance of heart and blood vessel side effects like heart attack and stroke. If these happen, they can be deadly. The risk of these side effects may be greater if you have heart disease or risks for heart disease. However, the risk may also be raised in people who do not have heart disease or risks for heart disease. The risk of these health problems can happen as soon as the first weeks of using this drug and may be greater with higher doses or with long-term use. This drug may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleeding. The risk is greater in older people. The risk is also greater in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs. If you are pregnant or you get pregnant while taking this drug, call your doctor right away. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. You can read more about naproxen’s side effects, warnings, and precautions here. Full prescribing information for naproxen is available here.

Sumatriptan is an oral medication indicated for the acute treatment of migraine with or without aura in adults and not for the prophylactic therapy of migraine attacks or for the treatment of cluster headache. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using sumatriptan while you are pregnant. Tell your doctor if you are breast-feeding. Call your doctor right away if you have chest, throat, neck, or jaw tightness, pain, pressure, or heaviness; break out in a cold sweat; shortness of breath; a fast heartbeat; a heartbeat that does not feel normal; or very bad dizziness or passing out. Very bad and sometimes deadly brain blood vessel problems like stroke have rarely happened with this drug. Call your doctor right away if you have weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on 1 side of the face, or change in eyesight. You can read more about sumatriptan’s side effects, warnings, and precautions here. Full prescribing information for sumatriptan is available here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: https://www.fda.gov/Safety/MedWatch/default.htm or call 1-800-FDA-1088.

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Headache pills – MedTelo.

ru

Contents

• Why does my head hurt?
• How to choose a medicine?
• Popular effective drugs
• Taking pills for headaches during pregnancy
• If the child has a headache
• Getting rid of headaches without pills

Even a hardened bachelor has pills for headaches in the medicine cabinet. Few people who suffer from pain can boast that they go to the doctor at the first sign of malaise. Pain is a clear signal indicating a malfunction of the body, the development of a disease. Taking medications at home is possible only with rare single attacks of headache. If you experience regular discomfort, you should consult a doctor.

Why does my head hurt?

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When choosing medicines for headache, a person needs to focus on the nature of painful sensations, the localization of discomfort, the frequency of manifestation of an unpleasant condition. There are several reasons for the development of discomfort in the head:

• Unstable nervous state, constant stress, neuroses.
• Genetic predisposition to migraines.
• Infectious diseases occurring in the tissues of the brain or in the muscles of the neck.
• Colds, flu, SARS, poisoning.
• Hypertension, hypotension, vegetovascular dystonia.
• Damage to the upper spine: osteochondrosis, myositis, cervical migraine.
• Vascular stenosis, cerebral aneurysm, pre-stroke condition.
• Lack of oxygen: being in an unventilated room, permanent residence in a gassed city.
• Fatigue, high mental, physical stress.

The cause of discomfort may be trauma, bruising of the skull. Pain can be localized in the back of the head, temples, frontal region. Give to the eyeballs, ears, brow ridges. Appear when bending, sneezing, coughing, intensify due to loud sounds. Each disease is characterized by its own characteristics of the manifestation of headache.

How to choose a medicine?

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Patients note different nature of pain sensations: aching, shooting, squeezing, arching, etc. Depending on the cause of the discomfort, the characteristics of the manifestation of unpleasant sensations in the head, the course of the disease, headache pills are selected. All drugs can be divided into groups, depending on the type of action:

• Non-steroidal anti-inflammatory drugs.
• Analgesics.
• Antispasmodics.
• Sedative preparations.

Migraine

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Intense obsessive headache is a symptom of migraine. Some patients note the unexpectedness of attacks, someone can describe the aura: a state before the onset of a headache, characterized by nausea, photophobia, intolerance to sharp sounds.

Since migraine is not curable, a person needs to use pills to reduce symptoms and help with headache. Recommended non-steroidal anti-inflammatory drugs:

• Aspirin.
• Ketorolac.
• Diclofenac.
• Metamizole.
• Ibuprofen.

Anti-inflammatory drugs stop inflammation in the irritated nerve centers of the brain, some have a blood-thinning effect.

People who notice the onset of migraine in the aura can take Almotriptan, Sumatriptan, which stop the development of an attack. Helps in the first hours of a headache. Caffetamin, which normalizes blood circulation, increases the tone of cerebral vessels, can act all day.

Effective for the treatment of migraine are drugs that combine several active substances in their composition, which have both analgesic and sedative, relaxing effects:

• Caffetin.
• Pentalgin.
• Solpadein.

Since migraine attacks occur regularly, a doctor should be consulted before taking the tablets. It is advisable not to increase the dosage of the drug for a day on its own if it has ceased to help. It is better to be examined and get a prescription for a new medicine.

Tension headaches

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If a person is in the same position for a long time, performs hard physical work, is subjected to strong psycho-emotional, mental stress, he may develop tension pains . Unpleasant sensations can last a short period, about an hour. Sometimes the discomfort doesn’t go away. Tablets for tension headaches are used the same as for migraine. The list can be supplemented with medicines:

• Indomethacin.
• Piroxicam.
• Ketoprofen.

Non-steroidal anti-inflammatory drugs are taken after meals with a small amount of water. It is not recommended to drink milk, tea, coffee. Alcoholic beverages in combination with drugs are strictly contraindicated. To avoid disruption of the intestines, on the day of taking these drugs, you need to drink Linex, Lactobacilli.

Vascular headaches

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Sometimes the cause of vasoconstriction is the growth of atherosclerotic plaques on the walls. To avoid discomfort, you need to eliminate the increase in cholesterol, and not just drink pills that help for a short time from headache vascular pain.

Unpleasant sensations in the brain are often caused by low blood pressure. Hypertension may not be the cause of constant discomfort, but a sharp increase in pressure once a day also causes discomfort. The therapist can prescribe a complex of drugs that normalize the pressure in the patient. Analgesics can be used to provide short-term relief from a vascular headache attack:

• Analgin.
• Piretin.
• Novalgin.
• Paracetamol.
• Baralgin.
• Nobol.
• Ronalgin.

Analgesics have a negative effect on the nervous system, heart muscle, and cause disruption of the intestinal tract. Therefore, without consulting a doctor, only a single dose of these drugs is possible if the headache is rare. You can drink 1 tablet at a time. If you drink more than six tablets a day, more than 20 times a week, addiction can develop to the drug, patients also have abuse headaches.

To relieve discomfort in the head due to a decrease in pressure, a person can take Citramon. This drug raises blood pressure due to the caffeine it contains.

If discomfort is caused by vasospasm, the therapist prescribes antispasmodics:

• No-shpu.
• Papaverine.
• Drotaverine.
• Halidor.
• Buscopan.

Usually you should drink not 1 tablet, but two, antispasmodics are dosed in half the dose. In order not to make a mistake, you need to carefully read the instructions. Combined preparations are effective for eliminating severe, obsessive migraine attacks with vascular damage:

• No-shpalgin.
• Spazmalgon.
• Andipal.

It is not advisable to take drugs of this group every time with discomfort and use for a long period if a person has heart, kidney, liver failure.

If the headache is caused by vasodilation of the brain, damage to the trigeminal nerve, a specialist may recommend taking selective serotonin receptor agonists:

• Zomig.
• Rolpex.

These drugs are used for particularly severe discomfort that is not relieved by conventional tablets. 1 tablet will not help get rid of recurring attacks, a course of drug therapy is necessary. You can not start self-treatment with agonists, as they can provoke complications and the development of side effects: anaphylactic shock, tachycardia, pharyngitis, bronchial asthma, etc. Therefore, it is important to consult a doctor at the first unpleasant symptoms.

Elimination of liquorodynamic pain

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Severe headache is caused by pressure drops in the cerebrospinal fluid. In this case, stretching, violation of the meninges occurs, the proportional arrangement of the brain structures changes.

CSF pain attacks can be provoked by infectious diseases, meningitis, benign and malignant brain tumors. Ordinary pills for severe headaches caused by drops in cerebrospinal fluid do little to help. It is urgent to consult a doctor if the patient complains of bursting headaches, aggravated by coughing, sneezing and not stopping from taking analgesics, non-steroidal anti-inflammatory drugs.

Psychogenic pain

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Mental disorders can provoke psychogenic pain in the head. The development of discomfort is noted even with minor deviations in the psyche. A person by will power convinces himself that he has a headache and indeed, after a while, begins to experience discomfort. Subject to psychogenic pain people suffering from depression, phobias, neuroses.

To find pills for headaches caused by nervous disorders, you need to contact a neurologist. Since discomfort develops not due to a systemic disease of the body, but as a result of self-hypnosis, conventional remedies, analgesics, antispasmodics, discomfort will not stop.

Treatment in this case consists in eliminating the source of stress, bringing the patient out of depression, drug therapy for a mental disorder. The therapist most often recommends taking sedatives.

• Phenobarbital.
• Codeine.
• Sedavit.
• Phenazepam.

Only by curing a mental illness or achieving a stable remission, one can get rid of a psychogenic headache.

Abuse headaches

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Overuse of headache medications has the opposite effect. Analgesics, non-steroidal anti-inflammatory drugs provoke the appearance of abuse headaches. If for a long period each time you take only one medicine, for example, Paracetamol, Citramon, Ibufen, other means to eliminate the discomfort of migraines, dull headaches appear, manifesting with different intensity during the day. It is not possible to relieve pain with conventional drugs. When taking the usual medicine in a larger dose, the discomfort recedes for a short time.

A neurologist can help in this situation. It is recommended to completely cancel the usual drug and a sparing regimen that allows you to endure a serious condition. With unpleasant sensations of high intensity, the doctor may recommend taking sedatives.

Popular effective drugs

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One-time pain relievers for headaches, taken without a doctor’s prescription, are popular:

1. Citramon.
2. Analgin.
3. Aspirin.
4. Ibuprofen.
5. No-shpa.
6. Ketoprofen.
7. Paracetamol.

Attention! You can not take several drugs at the same time with prolonged headache attacks! If the discomfort does not go away, you need to see a doctor and get a comprehensive treatment.

Taking headache pills during pregnancy

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Pregnant women quite often complain of discomfort in the occipital, temporal part of the head. Unpleasant sensations can be caused by hormonal changes in the body. If a woman has had migraines before, the attacks become aggravated during the bearing of a child. What to drink for a pregnant woman’s headache so as not to harm the fetus? To reduce discomfort, you can take once:

• No-shpu.
• Paracetamol.

These drugs are slightly absorbed into the systemic circulation and have minimal effects on the fetus. It is impossible to take citramon, codeine, analgin without the consent of the doctor. Only a specialist can evaluate the potential benefits of the drug for the mother and the possible risk of side effects for the child.

Important! A pregnant woman should not tolerate a headache for a long period of time. If the proposed drugs do not help to cope with the discomfort, contact a neurologist.

If the child has a headache

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A child who is already one year old can complain of a headache. Most often, discomfort is caused by infectious diseases. Children are recommended to take Ibuprofen, Paracetamol. You can drink not 1 tablet at a time, but only part of it. The dosage is calculated depending on the weight and age of the child.

Head pain medication for a child should not be chosen independently. You need to see a doctor who will prescribe treatment aimed at eliminating the cause of discomfort.

Headache relief without pills

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To reduce the amount of medication taken for migraines, you can use folk remedies that help with headaches.

1. Massage and self-massage. To relieve the pain of tension, you can rub the neck, the back of the skull.
2. A compress, warm or cold, is applied to the head, depending on what brings relief.
3. Outdoor walks, frequent airing of sleeping rooms.
4. Water procedures – taking a relaxing bath, preparing a foot bath with mustard.

Medicinal decoctions of herbs help eliminate nervous pain: anise, motherwort, lingonberry, hawthorn, coltsfoot leaves, bearberry. You can prepare a decoction of one type of herb or a mixture of them.

Remember, you can rarely take pills for headaches, no more than 1 time per month. If discomfort is noted often, discomfort does not go away when taking medications, you need to seek the help of medical professionals.

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Sumatriptan plus naproxen for acute migraine attacks in adults

The essence of the matter

The combination of sumatriptan with naproxen was beneficial for the treatment of migraine attacks in the studies we found. It was almost marginally superior to sumatriptan alone, but was much more effective than naproxen alone. Seizures were most effectively controlled with early medication, when the pain was mild.

Relevance

Migraine is a complex condition with a wide range of symptoms. Women are affected two to three times more than men, with the most common occurrence in the 30 to 50 age group. For many people, the main feature is a severe headache. Other symptoms include blurred vision, photophobia, increased sensitivity to sounds and smells, nausea and vomiting.

Both non-steroidal anti-inflammatory drugs (NSAIDs) and triptans are used to treat migraine headaches. This review looked at how well naproxen (NSAID) and sumatriptan (triptan) work in combination. The combination in one tablet is not available in most countries, but separate preparations are widely available and can be used together.

Study profile

On October 28, 2015, we searched for clinical trials investigating sumatriptan and naproxen in combination for the treatment of migraine headache in adults. Trial participants were given either sumatriptan plus naproxen, sumatriptan alone, naproxen alone, or placebo. They did not know what treatment they were receiving, and neither did the health workers who monitored them.

Main results

We found 13 studies, 12 of which (involving about 9300 people) provided information on how effective the treatment combination was.

The combination of sumatriptan with naproxen was superior to placebo for the relief of acute migraine attacks in adults. When the initial headache was mild, 5 out of 10 (50%) people who received the combination had pain relief after two hours, compared with 2 out of 10 (18%) who received placebo. Nearly 6 out of 10 (58%) people with moderate or severe pain who were treated with the combination had pain that subsided to mild or resolved after two hours, compared to 3 out of 10 (27%) who received placebo. The combination proved to be better than the same drugs at the same dosages alone. Results were obtained in 5 out of 10 (52%) people who received sumatriptan alone or in about 4 out of 10 (44%) who received naproxen alone.

The drug combination was better than placebo or each drug alone for alleviating other migraine symptoms (nausea, sensitivity to light and sound) and for loss of ability to function normally. Adverse events in the form of dizziness, tingling and burning of the skin, drowsiness, nausea, dyspepsia, dry mouth and chest discomfort were more common with sumatriptan (alone or in combination) than with placebo and naproxen. They were mostly mild to moderate in severity and rarely resulted in dropouts from studies.

Quality of evidence

Studies were conducted to a high standard and were generally large enough to provide reliable results, so most efficacy results were of high quality. The quality of the results for adverse events was reduced to moderate due to fewer events.

If you found this evidence helpful, please consider donating to Cochrane.