How often should you take Pepto Bismol. What are the active ingredients in Pepto Bismol. Is Pepto Bismol safe during pregnancy and breastfeeding. What are the potential side effects of Pepto Bismol. Can Pepto Bismol be used for food poisoning. How does Pepto Bismol work in the body. Are there any drug interactions with Pepto Bismol.

Understanding Pepto Bismol: Composition and Mechanism of Action

Pepto Bismol is a widely used over-the-counter medication for various gastrointestinal issues. Its active ingredient, bismuth subsalicylate, is responsible for its distinctive pink color and therapeutic effects. This compound breaks down into salicylic acid and bismuth in the stomach, each playing a crucial role in alleviating symptoms.

Salicylic acid, once absorbed into the bloodstream, inhibits the production of prostaglandins. These chemicals are responsible for intestinal inflammation, excess secretions, hypermotility, and diarrhea. By reducing prostaglandin formation, Pepto Bismol helps to calm the digestive system.

Bismuth, on the other hand, remains in the stomach and exerts antimicrobial activity. It prevents bacteria from attaching to the stomach lining and inactivates certain bacterial toxins. This dual action makes Pepto Bismol effective against various gastrointestinal issues.

Pepto Bismol Formulations and Concentrations

Pepto Bismol comes in several formulations, each with varying concentrations of bismuth subsalicylate:

• Original liquid: 262 mg per 15 mL
• Caplets and chewable tablets: 262 mg each
• Pepto Bismol Ultra: 2X concentration
• Pepto Diarrhea: 3X concentration

It’s crucial to read the label carefully and follow the dosing instructions to avoid errors, especially with the higher concentration products.

Proper Dosage and Administration of Pepto Bismol

Administering the correct dosage of Pepto Bismol is essential for its effectiveness and safety. For adults and children 12 years and older, a typical dose is 30 mL of the original liquid (524 mg) or two tablets. This equates to two measuring tablespoonfuls or one fluid ounce.

How frequently can Pepto Bismol be taken? The recommended dosing schedule for adults and children 12 years and older is:

1. 30 mL (524 mg) every 30-60 minutes as needed
2. Do not exceed 8 doses (4,192 mg) in 24 hours
3. Do not use for more than 2 days

For children under 12 years of age, consult a healthcare professional before administering Pepto Bismol. The use of salicylate products in this age group is generally not recommended due to the increased risk of Reye’s Syndrome.

FDA-Approved Uses and Off-Label Applications

The FDA has approved Pepto Bismol for treating several gastrointestinal issues:

• Diarrhea
• Heartburn
• Indigestion
• Nausea
• Stomach upset

Beyond these approved uses, Pepto Bismol has found off-label applications in certain medical situations. Can Pepto Bismol be used to treat peptic ulcers? In some cases, it’s used as part of a combination therapy to treat peptic ulcers caused by Helicobacter pylori infection. When combined with two antibiotics and a proton pump inhibitor, this regimen has shown approximately 90% effectiveness in eliminating H. pylori from the stomach.

Another off-label use of Pepto Bismol is in preventing and treating travelers’ diarrhea. While not officially approved for this purpose, some healthcare providers recommend it for individuals traveling to areas with a high risk of foodborne illnesses.

Potential Side Effects and Precautions

While Pepto Bismol is generally well-tolerated when used as directed, it’s important to be aware of potential side effects and take necessary precautions.

Common Side Effects

At recommended doses, adverse effects are uncommon. However, some individuals may experience mild side effects such as:

• Nausea
• Vomiting
• Constipation

A unique and harmless side effect of Pepto Bismol is the temporary darkening of the tongue and feces. This occurs when bismuth mixes with sulfur in saliva and digestive fluids, forming bismuth sulfide. This black substance is not harmful and will disappear once you stop taking the medication.

Allergies and Drug Interactions

Individuals with allergies to salicylates (such as aspirin) should avoid Pepto Bismol and other products containing bismuth subsalicylate. Additionally, those already taking other salicylate medications should consult their healthcare provider before using Pepto Bismol to prevent potential drug interactions.

Pepto Bismol and Food Poisoning: Effective Relief or Risky Choice?

Food poisoning often leads to uncomfortable gastrointestinal symptoms, prompting many to reach for over-the-counter remedies like Pepto Bismol. But is it safe and effective for this purpose?

For cases of food poisoning resulting in non-bloody diarrhea without fever, Pepto Bismol can be a safe initial treatment option. Its antimicrobial properties and ability to reduce intestinal inflammation can help alleviate symptoms and promote recovery.

However, caution is necessary. If diarrhea is bloody or accompanied by fever, these symptoms may indicate a bacterial infection or parasitic infestation requiring medical attention. In such cases, it’s crucial to seek professional healthcare rather than relying on self-treatment with Pepto Bismol.

Guidelines for Using Pepto Bismol in Food Poisoning

1. Assess your symptoms carefully before taking Pepto Bismol
2. Follow the label dosing instructions strictly
3. Do not administer to children without consulting a healthcare provider
4. If symptoms persist or worsen after 48 hours, seek medical attention
5. Stay hydrated by drinking plenty of fluids to replace those lost through diarrhea

Pepto Bismol During Pregnancy and Breastfeeding: Weighing the Risks

The use of Pepto Bismol during pregnancy and breastfeeding is a topic of concern for many women. Understanding the potential risks is crucial for making informed decisions about its use during these sensitive periods.

Pepto Bismol and Pregnancy

Healthcare professionals generally advise against using Pepto Bismol during pregnancy. Why is Pepto Bismol not recommended during pregnancy? The primary concern is the salicylate content, which can cross the placenta and potentially affect the developing fetus.

After taking Pepto Bismol, a pregnant woman’s bloodstream contains approximately the same amount of salicylate as if she had taken a dose of regular aspirin. This exposure poses several potential risks to the fetus:

• Low birth weight
• Jaundice
• Bleeding complications
• Possible birth defects

Given these potential risks, pregnant women are advised to seek alternative treatments for upset stomach and diarrhea under the guidance of their healthcare provider.

Pepto Bismol and Breastfeeding

Similar to pregnancy, the use of Pepto Bismol is not recommended during breastfeeding. Salicylates can enter breast milk, potentially exposing the nursing infant to these compounds.

The concerns regarding Pepto Bismol use while breastfeeding include:

• Potential adverse effects on the infant due to salicylate absorption
• Possible impact on the infant’s gastrointestinal system
• Risk of allergic reactions in sensitive infants

Nursing mothers are encouraged to consult their healthcare provider for safe alternatives to manage gastrointestinal issues while breastfeeding. There are several OTC medications available that pose less risk to nursing infants.

Drug Interactions and Contraindications

Understanding potential drug interactions and contraindications is crucial for the safe use of Pepto Bismol. While generally well-tolerated, it can interact with certain medications and medical conditions.

Notable Drug Interactions

1. Anticoagulants: Pepto Bismol may enhance the effects of blood thinners like warfarin, increasing the risk of bleeding.
2. Tetracycline antibiotics: Bismuth can reduce the absorption of these antibiotics, potentially decreasing their effectiveness.
3. Aspirin and other salicylates: Concurrent use may increase the risk of salicylate toxicity.
4. Probenecid and methotrexate: Pepto Bismol may interfere with the excretion of these drugs, potentially leading to increased blood levels and side effects.

Individuals taking any of these medications should consult their healthcare provider before using Pepto Bismol.

Medical Conditions and Contraindications

Certain medical conditions may preclude the use of Pepto Bismol or require careful consideration:

• Bleeding disorders: The salicylate component may increase the risk of bleeding.
• Gout: Salicylates can interfere with the excretion of uric acid, potentially exacerbating gout symptoms.
• Diabetes: Large doses of salicylates may affect blood sugar levels.
• Renal impairment: Reduced kidney function may lead to accumulation of salicylates and bismuth.

Individuals with these conditions should seek medical advice before using Pepto Bismol.

Long-term Use and Potential Complications

While Pepto Bismol is generally safe for short-term use, prolonged or excessive use can lead to potential complications. Understanding these risks is crucial for responsible usage.

Salicylate Toxicity

One of the primary concerns with long-term or high-dose use of Pepto Bismol is salicylate toxicity. Symptoms of salicylate toxicity may include:

• Tinnitus (ringing in the ears)
• Nausea and vomiting
• Rapid breathing
• Confusion or disorientation
• In severe cases, seizures or coma

To prevent salicylate toxicity, it’s crucial to adhere to the recommended dosage and duration of use. If symptoms persist beyond two days, consult a healthcare provider rather than continuing self-treatment.

Bismuth Accumulation

While less common, long-term use of bismuth-containing products like Pepto Bismol can lead to bismuth accumulation in the body. This can potentially result in:

• Encephalopathy (brain dysfunction)
• Osteoarthropathy (joint and bone problems)
• Nephropathy (kidney damage)

These complications are rare with normal, short-term use but become a concern with prolonged or excessive intake.

Gastrointestinal Effects

Paradoxically, long-term use of Pepto Bismol can sometimes lead to gastrointestinal issues, including:

• Chronic constipation
• Impaction of hardened stool
• Potential interference with normal gut flora

These effects underscore the importance of using Pepto Bismol as directed and not relying on it as a long-term solution for chronic gastrointestinal issues.

Alternatives to Pepto Bismol

While Pepto Bismol is effective for many gastrointestinal issues, there are situations where alternatives may be more appropriate. Understanding these options can help individuals make informed decisions about their healthcare.

Over-the-Counter Alternatives

1. Loperamide (Imodium): Effective for diarrhea but doesn’t address nausea or indigestion
2. Simethicone (Gas-X): Helps relieve gas and bloating
3. Calcium carbonate antacids (Tums, Rolaids): Effective for heartburn and indigestion
4. Famotidine (Pepcid): Reduces stomach acid production, helpful for heartburn and acid reflux
5. Ginger supplements: Natural option for nausea relief

Natural Remedies

For those preferring natural alternatives, several options may provide relief for mild gastrointestinal issues:

• Peppermint tea: Can soothe upset stomach and reduce nausea
• Chamomile tea: Known for its calming effects on the digestive system
• Probiotic foods or supplements: May help restore balance to gut flora
• Apple cider vinegar: Some find it helpful for indigestion when diluted with water
• BRAT diet (Bananas, Rice, Applesauce, Toast): Often recommended for mild diarrhea

While these natural remedies can be effective for mild symptoms, it’s important to seek medical attention for severe or persistent gastrointestinal issues.

When to Seek Medical Attention

In some cases, symptoms may require professional medical evaluation rather than self-treatment with Pepto Bismol or its alternatives. Seek medical attention if you experience:

• Severe abdominal pain
• Bloody stools
• High fever accompanying gastrointestinal symptoms
• Symptoms persisting for more than 48 hours
• Signs of dehydration (dark urine, dizziness, dry mouth)

These symptoms may indicate more serious conditions requiring prompt medical intervention.

Is Pepto Bismol Safe? | Poison Control

The Bottom Line

Pepto Bismol contains bismuth subsalicylate and is used for stomach upset and diarrhea. Bismuth can temporarily cause black tongue and feces. Salicylate toxicity can occur after overdose. Avoid Pepto Bismol if you take aspirin regularly. It is not advisable during pregnancy and breastfeeding. Children under 12 years of age should not take salicylate products due to an increased risk for Reye’s Syndrome.

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What’s in Pepto Bismol?

The active ingredient in Pepto Bismol^® is bismuth subsalicylate. This compound plus a little red dye gives Pepto Bismol its pink color. (According to a Procter & Gamble historian, the color was originally chosen to appeal to children and reduce their fears.) Pepto Bismol original liquid contains 262 mg per 15 mL. Caplets and chewable tablets each contain 262 mg. A “dose” is usually 30 mL of Pepto liquid (524 mg) or 2 tablets for adults and children 12 years of age and older. A dose of 30 mL is the same as 2 measuring tablespoonfuls or 1 fluid ounce. Be sure to read the label, because some Pepto Bismol products have higher amounts of the active ingredient. Pepto Bismol Ultra is twice as concentrated, and Pepto Diarrhea is three times as concentrated as the original Pepto Bismol liquid. Look for “2X” and “3X” on these products, and follow the dosing information on the labels carefully to avoid errors.

Bismuth subsalicylate is the active ingredient in quite a few OTC (over-the-counter) products for relief of stomach upset and diarrhea. Other products that contain bismuth subsalicylate include include Bismatrol^® and Kaopectate^®.

What does Pepto Bismol do?

Pepto Bismol is an OTC medicine that is approved by the FDA to treat diarrhea, heartburn, indigestion, nausea, and stomach upset. Outside its FDA-approved uses, Pepto Bismol is sometimes taken “off-label” to treat peptic ulcers caused by Helicobacter pylori infection. A combination of bismuth subsalicylate, two antibiotics, and a proton pump inhibitor (such as Nexium^®) is around 90% effective at eliminating H. pylori in the stomach. Pepto Bismol has also been used off-label to prevent and treat travelers’ diarrhea.

Once in the stomach, bismuth subsalicylate breaks down into salicylic acid and bismuth. Salicylic acid is almost completely absorbed into the bloodstream, while bismuth remains in the stomach. Salicylic acid inhibits the formation of chemicals called prostaglandins, which are responsible for intestinal inflammation, excess secretions, hypermotility, and diarrhea. Bismuth exerts antimicrobial activity by preventing bacteria from attaching to the stomach lining and also by inactivating some bacterial toxins. 

What are Pepto Bismol’s side effects?

Adverse effects are uncommon with recommended doses, but mild side effects can occur such as nausea, vomiting, and constipation. When the bismuth in Pepto Bismol mixes with sulfur in saliva and digestive fluids, a black substance (bismuth sulfide) is formed that can darken the tongue and feces temporarily. This is harmless and will go away when you stop taking the medication.

If someone is allergic to salicylates (like aspirin) or already takes another salicylate medication, they should not use Pepto Bismol or any other product containing bismuth subsalicylate.

Should I take Pepto Bismol for food poisoning?

Diarrhea that occurs with food poisoning might improve with Pepto Bismol. As long as the diarrhea is not bloody and you don’t have a fever, Pepto Bismol is likely a safe initial treatment option. Follow the label dosing instructions carefully, and do not give the medication to children. If you have bloody diarrhea or a fever, these can be signs of a bacterial infection or parasites, which require medical attention.

Can I take Pepto Bismol while pregnant?

Salicylates such as bismuth subsalicylate should be avoided during pregnancy. After taking Pepto Bismol, a mother’s bloodstream contains about as much salicylate as if she had taken a dose of regular aspirin. Salicylate cross the placenta, so the baby can be exposed. The potential exists for low birth weight, jaundice, bleeding, and birth defects. 

Can I take Pepto Bismol while breastfeeding?

It is recommended that nursing mothers avoid taking bismuth subsalicylate and use an alternative treatment for upset stomach and diarrhea. After taking Pepto Bismol, a mother’s bloodstream contains about as much salicylate as if she had taken a dose of regular aspirin. Salicylates enter breast milk. Adverse effects might occur due to absorption of salicylate by the nursing infant. A number of alternative OTC medications exist for diarrhea or upset stomach, such as loperamide (Imodium^®) and antacids. 

Is Pepto Bismol overdose possible?

Overdose is possible, and toxic effects are most often due to the salicylate content. People who already take aspirin or other salicylates, the elderly, and people with kidney disease might be at higher risk for adverse effects. Bismuth is not absorbed from the GI tract, so bismuth toxicity is unlikely.

The symptoms of salicylate toxicity include vomiting, abdominal pain, fever, confusion, excessive drowsiness, rapid breathing, and ringing in the ears (tinnitus). If an adult takes a large dose of Pepto Bismol all at once (more than the contents of a full bottle of tablets or liquid) or uses the maximum dose for a prolonged period of time, these symptoms might signal the need for medical attention. A child who accidentally gets too much, or someone who takes Pepto Bismol to harm themself, will probably need to go to an ER. A call to Poison Control will help decide whether someone got too much Pepto, and what to do next.

To avoid toxic effects from bismuth subsalicylate, pay close attention to the dosing instructions on product labels. The maximum dosage is 8 doses per day of regular strength Pepto Bismol (4200 mg daily) for no more than 2 days. Observing these precautions should help you stay well within the safe range and avoid toxicity. 

What else should I know about Pepto Bismol?

For children under the age of 12 years, always consult a physician about whether to give Pepto Bismol. There is a serious illness called Reye’s Syndrome that has been associated with the use of aspirin-related products in children who have or are recovering from an illness causing a fever such as the flu or chickenpox. Pepto Bismol should be avoided in these children to prevent risking this rare condition. A different product called Pepto Kids does not contain bismuth subsalicylate and is marketed for use in children—it contains the active ingredient calcium carbonate, similar to many OTC antacids. Be sure to read all Pepto^® labels carefully.

What to do if someone takes too much or has a bad reaction to Pepto Bismol

If someone takes too much or experiences worrisome side effects from taking Pepto Bismol, get an immediate, personalized recommendation online at www.poison.org or call Poison Control at 1-800-222-1222. Both options are free, confidential, and available 24 hours a day.

PEPTO-BISMOL® IS A REGISTERED TRADEMARK OF PROCTER & GAMBLE, CINCINNATI, OH 45202.

Leslie A. McCament-Mann, RPh, PhD
Clinical Toxicologist

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Prevention Tips

• Store medicines up, away, and out of the reach of children and pets.
• Always check labels for dosing recommendations.
• Avoid using bismuth subsalicylate or any medication related to aspirin in children under 12 years of age unless your physician has recommended it.
• Do not use Pepto Bismol or other products containing bismuth subsalicylate if you are allergic to aspirin or have already taken a medication containing salicylate.

This Really Happened

A 79-year-old man went to an ER with increasing confusion, hearing difficulty, and uncoordinated gait (ataxia) that had lasted for a week. While other possible causes were being investigated, it was discovered that he had been drinking 1 or 2 bottles of Pepto Bismol daily for the previous 6 months to treat acid reflux (GERD). A high level of salicylate was measured in his blood. Pepto Bismol was discontinued and he was treated in the hospital with IV fluids to increase salicylate elimination through his kidneys. All of his symptoms resolved over several days in the hospital (from Halani & Wu, 2020).

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For More Information

Bismuth subsalicylate (oral route). Rochester (MN): Mayo Clinic; updated 1 Nov 2022 [accessed 22 Nov 2022].

Drug information portal: bismuth subsalicylate. Bethesda (MD): National Library of Medicine; updated Nov 2022 [accessed 21 Nov 2022].

Pepto Bismol®. Cincinnati: Procter & Gamble [accessed 21 Nov 2022].

Treatment for food poisoning. Bethesda (MD): National Institutes of Health; reviewed Jun 2019 [accessed 21 Nov 2022].

References

Bierer DW. Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis. 1990;12 Suppl 1:S3-S8. 

Chyka PA, Erdman AR, Christianson G, et al. Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2007;45(2):95-131. 

Doheny K. Pepto’s pink for a reason. Los Angeles: LA Times; 22 Dec 1992 [accessed 28 Nov 2022].

Drugs and lactation database (LactMed): bismuth subsaliclyate. Bethesda (MD): National Library of Medicine; revised 18 Jul 2022 [accessed 18 Nov 2022].

Halani S, Wu PE. Salicylate toxicity from chronic bismuth subsalicylate use. BMJ Case Rep. 2020;13(11):e236929.

Poisoned?

Call


1-800-222-1222


or

HELP ME online

Prevention Tips

• Store medicines up, away, and out of the reach of children and pets.
• Always check labels for dosing recommendations.
• Avoid using bismuth subsalicylate or any medication related to aspirin in children under 12 years of age unless your physician has recommended it.
• Do not use Pepto Bismol or other products containing bismuth subsalicylate if you are allergic to aspirin or have already taken a medication containing salicylate.

This Really Happened

A 79-year-old man went to an ER with increasing confusion, hearing difficulty, and uncoordinated gait (ataxia) that had lasted for a week. While other possible causes were being investigated, it was discovered that he had been drinking 1 or 2 bottles of Pepto Bismol daily for the previous 6 months to treat acid reflux (GERD). A high level of salicylate was measured in his blood. Pepto Bismol was discontinued and he was treated in the hospital with IV fluids to increase salicylate elimination through his kidneys. All of his symptoms resolved over several days in the hospital (from Halani & Wu, 2020).

Is It Safe, Can You Give It For Diarrhea And Vomiting, And Dosage Chart

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When dogs feel under the weather, some pet parents think an easy fix is to give their pup something from their medicine cabinet. In some cases, you can give dogs human meds, but human meds are usually off-limits for dogs. If your dog is having tummy troubles, you may wonder, can you give a dog Pepto Bismol? Our guide gives you the lowdown on Pepto Bismol and dogs.

Table Of Contents

1. What Is Pepto Bismol?
2. Can I Give My Dog Pepto Bismol?
3. What Dogs Should Not Take Pepto Bismol?
4. Pepto Bismol Dosage For Dogs
5. Frequently Asked Questions
6. Alternatives To Pepto Bismol
7. Learn More About Dog GI Problems

What Is Pepto Bismol?

Pepto Bismol is an oral over-the-counter (OTC) medicine that many people use to treat an upset stomach, heartburn, nausea, or diarrhea. The active ingredient is bismuth subsalicylate, which belongs to a drug class called salicylates. Pepto Bismol is available in liquid form (the “pink stuff”), chewable tablets, and caplets (caplets aren’t recommended for dogs).

Can I Give My Dog Pepto Bismol?

Is Pepto Bismol safe for dogs? Pepto Bismol is generally safe for dogs, but that doesn’t mean you should give it to your pup without first checking with your veterinarian. Never give your pup human over-the-counter (OTC) medications without your vet’s okay. Your vet knows your dog’s medical conditions and health history, so they can determine what is and isn’t safe for your particular pup.

Some veterinary experts are hesitant about recommending Pepto Bismol because the salicylates in the medication could cause gastric bleeding in some dogs. And the bismuth in the medication typically turns dog poop black, making it very difficult to spot any blood in a dog’s stool — a sign that there’s gastric bleeding.

Warning: Never give cats Pepto Bismol or any product containing bismuth subsalicylate. Bismuth subsalicylate is extremely toxic for cats.

What Can Pepto Bismol Treat In Dogs?

Pepto Bismol can help treat your dog’s upset stomach, vomiting, or diarrhea. It can also cause temporary constipation, so if that’s a problem for your pup, you probably shouldn’t give it to him.

What Dogs Should Not Take Pepto Bismol?

When is Pepto Bismol bad for dogs? Pepto Bismol is unsafe for dogs who fall into the categories listed below. Again, always check with your vet before giving your dog Pepto Bismol.

• Dogs with bleeding disorders
• Dogs who are pregnant or nursing
• Dogs who are currently taking antibiotics or aspirin
• Dogs taking non-steroidal anti-inflammatory medications such as Rimadyl and Deramaxx
• Puppies
• Dogs with allergies to the active ingredients (i.e., bismuth subsalicylate)

Pepto Bismol Dosage For Dogs

The following dosage recommendations are for regular strength Pepto Bismol liquid or chewable tablets. Do not give your dog Ultra Pepto Bismol, which is concentrated with twice the amount of bismuth subsalicylate. This 2X concentrate is unsafe for your pup. Also, do not give your dog Pepto Bismol caplets. If you’ve never given your dog Pepto Bismol before, talk to your vet first to make sure it’s safe for your pup.

Liquid Dosage

The recommended liquid dosage is 1 teaspoon (5 ml) for every 10 pounds. You can give it to your pup every 6 to 8 hours, but don’t give more than a few doses or for longer than 24 hours. If your dog is still having stomach issues after a few doses, contact your vet.

The best way to give your dog the liquid is to use a plastic syringe. Place the syringe toward the back of your dog’s tongue and slowly push the plunger. Then hold his muzzle to make sure he swallows it.

Liquid Pepto Bismol Dosing Chart

Chewable Tablet Dosage

The recommended tablet dosage is 8. 5 mg per 1 pound. Keep in mind, this can get difficult to calculate and cut up the tablets to the specific dosage for your dog’s weight. For example, a 20-pound dog would take 65% of one tablet based on this recommended dosage. Here’s a Pepto Bismol tablet dosage chart for dogs to help you figure out how to divide the tablets up based on your dog’s weight.

Tablet Pepto Bismol Dosing Chart

*Based off of a chewable tablet that is 262mg

Frequently Asked Questions

Here are some of the questions our readers ask most often about Pepto Bismol and dogs.

How Often Can You Give A Dog Pepto Bismol?

If you follow the dosage recommendations above, and your dog isn’t getting better after a few doses, don’t continue giving your dog Pepto Bismol. As we said above, Pepto Bismol has the potential to cause gastric bleeding, so it’s not a good idea to give your dog more than a few doses.

Also, if Pepto Bismol isn’t helping your dog, then your dog may have a more serious digestive issue that needs veterinary care.

Can My Dog Overdose On Pepto Bismol?

If your dog accidentally consumes too much Pepto Bismol, this is a veterinary emergency. In high enough quantities, it can be life-threatening. Contact your vet immediately or go to an emergency vet clinic.

Signs of overdose include:

• Diarrhea or bloody stool
• Vomiting
• Rapid breathing
• Fever
• Weakness, tremors, seizures, or collapse

What If My Dog Ate Pepto Bismol Tablets?

If your dog got into a package of Pepto Bismol tablets, he may very well have eaten a dangerous amount of Pepto Bismol. Seek veterinary care immediately, as this can be life-threatening. See above for the signs of an overdose.

Can You Use Pepto Bismol For Hot Spots On Dogs?

You may have heard that Pepto Bismol is an effective home remedy for reducing hot spot itchiness, but we don’t recommend it. There’s no scientific proof that it helps hot spots. More important, if you slather Pepto on a hot spot, your dog likely will lick it off and could end up overdosing. Learn more about treating hot spots.

Alternatives To Pepto Bismol

Other OTC medications that treat mild stomach ailments and are generally considered safe for dogs include Pepcid (famotidine) and Imodium (loperamide). Learn more about these options in our article on which OTC meds are safe for dogs. But again, never give your dog any OTC medications without your vet’s okay and dosing recommendation.

Another option to relieve mild stomach upset and diarrhea, as well as constipation, is to give your dog plain pureed pumpkin (with no spices). Mix in ½ to 4 tablespoons, depending on your dog’s size, to your dog’s meal.

For occasional mild stomach issues, vets also often suggest withholding food for 12 to 24 hours and then slowly reintroducing bland food, such as plain cooked rice. But always make sure that you’re keeping your dog hydrated. This is especially important if he’s losing fluids from diarrhea or vomiting.

Learn More About Dog GI Problems

See our articles on dog vomiting, diarrhea, and upset stomachs to learn more about causes, symptoms to look out for, other treatment options, and when it’s time to see your vet. If your dog is experiencing severe vomiting, diarrhea, or other gastrointestinal issues, you should call your vet immediately. Also, if your pup has chronic stomach problems, your vet can help determine the cause. It may require a diet change.

Tagged With: Reviewed By Dr. Pendergrass, DVM

Pepto Bismol for Children: Safety, Usage, Dosage and Side Effects

Pepto Bismol for Children: Safety, Usage, Dosage and Side Effects – Child

Image: Shutterstock

IN THIS ARTICLE

• At what age can a child take Pepto-Bismol?
• How does Pepto Bismol work?
• Pepto Bismol dosage for children
• Why should children not take Pepto Bismol? (Side effects)
• Warnings

Children often complain of frequent abdominal pain, especially if they often eat out. In such cases, parents may consider using over-the-counter medications such as Pepto-Bismol for children. Pepto-bismol (bismuth subsalicylate) is considered a safe and effective treatment for gastrointestinal disorders such as acid reflux, diarrhea, and indigestion. But what should be the dosage of Pepto-Bismol for children?

Read on to learn about the mechanism of action, recommended dosage, safety, side effects and alternatives to Pepto-Bismol in children.

At what age can a child take Pepto-Bismol?

Pepto-Bismol is used to treat certain digestive problems such as diarrhea, indigestion, nausea, gas, belching, heartburn, and feeling full. However, Pepto-Bismol should only be taken by children 12 years of age or older. Do not give it to young children without the advice of a doctor. (one) .

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Bismuth subsalicylate, the active ingredient in pepto-bismol, is a derivative of aspirin (acetylsalicylic acid or ASA), which can be harmful to young children. Therefore, children between the ages of 2 and 11 can be given an alternative medicine called Pepto Kids instead. (two) . This is a drug designed specifically for young children. The main ingredient in this medication is calcium carbonate, which is considered safe for children.

How does Pepto Bismol work?

Pepto-Bismol’s key ingredient is bismuth subsalicylate, which helps (3)

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  A. Pepto-Bismol liquid

Take 30 ml (two tablespoons or the supplied dosing cup) every 30 minutes up to one hour for a maximum of eight doses (240 ml) per day (24 hours). Shake suspension well before use.

For diarrhea or travelers’ diarrhea, take 15 ml every 30 minutes or 30 ml every hour for a maximum of eight doses (120 ml) in 24 hours. Problems due to overindulgence in food/drink can be alleviated by taking 15 ml every half hour.

B. Pepto-Bismol Chewable Tablets or Capsules

• Take two chewable tablets or regular capsules every 30 minutes to an hour, as needed.
• Do not exceed eight doses (16 tablets) of regular capsules in a 24 hour period.
• While chewable tablets should be chewed or dissolved in the mouth, regular dosage capsules should be swallowed with water.
• For Pepto-Bismol Ultra capsules for diarrhea, take one capsule every 30 minutes or two capsules every hour. For problems with overeating or indigestion, take one capsule every 30 minutes. Dosage should be limited to eight capsules per day.

Additional instructions

• Do not take the medicine for more than two days. Call your doctor if diarrhea persists for more than two days.
• Pepto-Bismol may cause dehydration in children with diarrhoea. Therefore, make sure your child drinks clear liquids frequently.

C. Pepto Kids

Pepto Kids is a child safe version of Pepto-Bismol. It is suitable for children aged 2-11 years old. Below is the dosage for Pepto-Kids.

• Children 24 to 47 pounds and 2 to 5 years of age should take one tablet as needed. The maximum dose is three tablets per day (24 hours).
• Children 48-95 lbs and ages 6-11 should take two tablets as needed. The maximum dosage is six tablets in 24 hours.

Why should children not take Pepto Bismol? (Side Effects)

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If children under 12 years of age take Pepto-Bismol, it can cause dangerous complications.

The active ingredient of the drug is bismuth subsalicylate. It shows limited efficacy in children and poses a high risk of Reye’s syndrome. (one) . Reye’s syndrome is characterized by a sharp increase in pressure in the brain and damage to the liver due to the accumulation of fat.

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It can cause symptoms such as convulsions, delirium, fainting, vomiting, irritability, lethargy and confusion, and is often preceded by a viral infection such as flu, chickenpox or influenza. (7) (7) .

Here are some other side effects of pepto-bismol. (8) .

• Darkening of the stool and tongue may occur due to the reaction of its constituent bismuth with sulfur in saliva and the digestive system. As a result of the reaction, black bismuth sulfide can be formed. As a rule, it is harmless. However, if the effect lasts more than three days, see your doctor.
• Overdose may result in deafness, tinnitus, exhaustion or dizziness and confusion.

Warnings

Pepto-Bismol should be avoided in the following situations, even for older children. (one) .

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• Children and adolescents who have recently had symptoms of chickenpox or influenza and are recovering from them
• Children allergic to salicylates and aspirin
• Children currently taking any other salicylate drugs/products
• Children with ulcer, pre-existing black or bloody stools, or bleeding

Children and adults taking medicines for the following conditions should consult their doctor before taking Pepto-Bismol. (one) .

• Diabetes
• Gout
• Arthritis
• Blood thinning (anticoagulation)

Pepto-Bismol may interact with other drugs. So, if your child is taking any medication, it’s best to talk to a doctor before giving him Pepto-Bismol. (one) .

You should also check with your doctor before giving Pepto Bismol to a child if they have any health problems such as fever or mucus in their stools. (one) .

When your baby gets sick, it’s natural to be worried and seek help immediately. Although over-the-counter medicines such as Pepto-Bismol are readily available, they are not always safe for children.

one. PEPTO-BISMOL – a set of bismuth subsalicylate; National Institutes of Health
two. PEPTO KIDS – calcium carbonate tablets, chewable; National Institutes of Health
3. Patrick Budisak and Malak Abbas; Bismuth subsalicylate; Statpurls (2021).
Four. PEPTO-BISMOL ULTRA – suspension of bismuth subsalicylate; National Institutes of Health
5. PEPTO BISMOL – bismuth subsalicylate tablet; National Institutes of Health
6. PEPTO-BISMOL ULTRA- bismuth subsalicylate tablet; National Institutes of Health
7. Reye Syndrome Information Page; National Institute of Neurological Disorders and Stroke
8. Reye Syndrome; American Academy of Pediatrics
9. Pepto-Bismol (bismuth subsalicylate); NHS

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Adult Medication

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Acticlate [DSC]; Avidoxy; Doryx; Doryx MPC; Doxy 100; Lymepak [DSC]; Mondoxyne NL; Morgidox[DSC]; Okebo [DSC]; Oracea; TargaDOX; Vibramycin

Trade names: Canada

APO-Doxy; APO-Doxycycline MR; Apprilon; doxycin; doxytab; Periostat; PMS-Doxycycline [DSC]; TEVA-Doxycycline

What is this drug used for?

• Used to treat acne.
• It is used to treat and prevent bacterial infections.
• Used to prevent malaria.
• It is used to treat periodontitis (inflammation of the tissues around the tooth). It is used when removing tartar and leveling the surface of the tooth roots.
• This drug is used to treat red pimples.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you are taking any of the following drugs: Acitretin, isotretinoin, or penicillin.
• If you are breastfeeding or planning to breastfeed. You may need to stop breastfeeding.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural medicines and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• With prolonged use of the drug, it is necessary to conduct a blood test. Talk to a medical specialist.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• Do not use beyond the prescribed time. A secondary infection may occur.
• In case of an individual allergic reaction to sulfites, it is necessary to consult a doctor. Some foods contain sulfites.
• You can easily get sunburn when using this drug. Be careful if you will be in the sun. If you get sunburn easily while taking this drug, talk to your doctor.
• Against the background of the use of this drug, severe reactions from the skin are possible. These include Stevens-Johnson syndrome (SSD), toxic epidermal necrolysis (TEN), and other serious skin reactions. Sometimes internal organs can also be affected. Such reactions can lead to death. Seek immediate medical attention if you experience skin symptoms such as redness, swelling, blisters, or peeling; with redness or irritation of the eyes; sores in the mouth, throat, nose, eyes or genitals, or any other area of ​​the skin; with high fever, chills, body pain, shortness of breath, or swollen lymph nodes.
• The effectiveness of birth control pills and other hormonal birth control may decrease. Use other types of birth control, such as a condom, in addition to taking this drug.
• In children under 8 years of age, this drug may cause yellowish brown or grayish brown teeth to be stained. The same effect is found in the fetus when the drug is used at certain points during pregnancy. This tooth staining is irreversible. Other dental problems have also been reported. The use of the drug can also lead to impaired bone growth in these age categories. If you have any questions, please consult your doctor.
• In most cases, this drug is not intended for use in children under 8 years of age. However, there may be times when these children are likely to need this drug. Consult your doctor.
• Tooth discoloration has also been noted in adults. It took place after stopping the drug and cleaning the teeth at the dentist. Consult your doctor.
• When used during pregnancy, the drug may have a harmful effect on the fetus. If you are pregnant or become pregnant while taking this drug, call your doctor right away.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Call your doctor or get medical help right away if you have any of the following signs or symptoms that could be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of liver problems such as dark urine, fatigue, lack of appetite, nausea or abdominal pain, light-colored stools, vomiting, yellowing of the skin or eyes.
• Signs of problems with the pancreas (pancreatitis), such as severe abdominal pain, severe back pain, severe indigestion, and vomiting.
• Pain or pressure in the chest or a fast heartbeat.
• Difficulty urinating or a change in the amount of urine produced.
• fever, chills, sore throat; the appearance of bruising and bleeding for unexplained reasons; pronounced feeling of tiredness or weakness.
• Sore throat.
• Difficulty swallowing.
• Pain in the joints or muscles.
• Rapid breathing.
• Hyperemia (blush).
• Severe dizziness or fainting.
• Change in skin color.
• Vaginal itching or discharge.
• Diarrhea often occurs when taking antibiotics. In rare cases, severe diarrhea caused by the bacteria Clostridium difficile (C. diff.) [CDAD] may occur. Sometimes this leads to intestinal problems, ending in death. CDAD may occur during or several months after antibiotics are taken. If you experience pain, abdominal cramps, or very loose, watery, or bloody stools, contact your doctor immediately. Check with your doctor before treating diarrhea.
• This drug has been associated with increased intracranial pressure. In most cases, blood pressure returns to normal when this drug is stopped. Sometimes you may experience loss of vision, which may persist after you stop taking this drug. Call your doctor right away if you have a headache or visual problems such as blurred vision, double vision or loss of vision.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Diarrhea, indigestion or vomiting.
• Decreased appetite.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

All oral preparations:

• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.
• Some medications need to be taken with food, and some need to be taken on an empty stomach. There are drugs that can be taken both with food and on an empty stomach. Ask your pharmacist how to take this drug.
• At the same time with this drug, it is recommended not to consume milk, dairy products and other foods rich in calcium. Treatment with this drug may not be effective. If you have any questions, ask your doctor or pharmacist.
• Drink plenty of non-caffeinated fluids, unless your doctor tells you to drink less fluids.
• Do not take bismuth (Pepto-Bismol®), calcium, iron, magnesium, zinc, multivitamins with minerals, colestipol, cholestyramine, didanosine, or anti-acid agents within 2 hours of taking this drug.

Tablets and capsules:

• Take this drug with a full glass of water.
• Do not lie down after taking this drug. This will help reduce the likelihood of irritation of the pharyngeal mucosa. Ask your pharmacist how long it takes before you can lie down after taking this medicine.

Sustained release tablets:

• Swallow whole. Don’t chew or crumble.
• With the permission of the doctor, the tablet can be broken.
• You can sprinkle the contents of the tablet into applesauce. Break the tablet with care so as not to crush the pellets. Do not chew, crush or damage the contents of the tablet.
• Do not mix with applesauce.
• If taken in a mixed form, swallow the mixture immediately. Do not store for future use.

All liquid formulations:

• Liquid doses should be measured with caution. Use the dispenser that comes with the medication. If the dispenser is not provided in the package, ask the pharmacist for a dosing agent for this drug.

Liquid (suspension):

• Shake well before use.

Injection:

• This drug is administered by infusion intravenously continuously for a certain time.

What if I miss a dose of a drug?

All oral preparations:

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

Injection:

• See your doctor for further instructions.

How do I store and/or discard this drug?

All oral preparations:

• Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
• Do not take this drug after the expiration date.
• Do not take this drug if it has been stored differently than you were told.

Solution (syrup):

• Throw away all unused portions of the drug.

Liquid (suspension):

• Store the liquid (suspension) at room temperature. Throw away any unused serving after 2 weeks.

Injection:

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

All forms:

• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options.