What Are Possible Side Effects Of Hydroquinone For Your Skin?

As you look at skincare options to address hyperpigmentation and melasma, you may be wondering if hydroquinone has any side effects. Continue reading to learn more about the risks and side effects associated with hydroquinone.

What are the most common side effects of hydroquinone treatments?

Although hydroquinone is considered the “gold standard” in treating conditions like melasma and hyperpigmentation, there are some side effects, including:

• Stinging
• Redness
• Irritation
• Dry skin
• Allergic contact dermatitis, or allergic reaction to hydroquinone
• Inflammation

Side effects of hydroquinone are typically mild to moderate. Many formulas include steroids and retinoids to help boost efficacy and reduce the likelihood of skin irritation. Your doctor may conduct a patch test on your skin to check for allergies before starting you on treatments.

It’s also not uncommon for treatments to begin at a lower dose for the first week to allow your skin to adjust to hydroquinone treatments. After the first week, you may be advised to increase the frequency of applications.

It’s also important to note that hydroquinone causes skin to be much more sensitive to ultraviolet light. You should be certain to take precautions to protect affected areas from sunlight, including using sunscreens and wearing protective clothing, such as broad-brimmed hats or long sleeves.

Hydroquinone and ochronosis

Hydroquinone is not totally free from scrutiny despite being considered a safe and effective treatment worldwide. This is evident as recently as September 2020, when over-the-counter hydroquinone formulas with concentrations of 2% or less were pulled from shelves over concerns of misuse.

One of these concerns is a rare condition called ochronotic, which results in a blue-black pigmentation of the skin. Ochronosis occurs typically after prolonged use of hydroquinone on large patches of the skin (Faridi). Although hydroquinone is a skin-lightening agent, it is intended for use on dark spots only – NOT as an overall skin bleaching treatment. Once ochronosis occurs, it is very difficult to treat.

Some other misconceptions about hydroquinone exist despite a lack of evidence. For example, hydroquinone has been cited as hazardous because it is produced from benzene, a known carcinogen. However, studies over the 60 year period hydroquinone has been commonly prescribed do not indicate any dangers of toxicity in the topical use of hydroquinone (Grimes).

Another concern stemming from internet rumors claims that hydroquinone actually causes melasma, rather than improving or curing it. However, no credible studies indicate that hydroquinone causes melasma.

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Related:

• Diet For Hyperpigmentation: All Your Questions Answered
• Vitamins For Hyperpigmentation: All Your Questions Answered

References

• Faridi W, Dhamoon AS. Ochronosis. [Updated 2021 Aug 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560534/
• Grimes PE, Ijaz S, Nashawati R, Kwak D. New oral and topical approaches for the treatment of melasma. Int J Womens Dermatol. 2018;5(1):30-36. Published 2018 Nov 20. doi:10.1016/j.ijwd.2018.09.004
• Schwartz C, Jan A, Zito PM. Hydroquinone. [Updated 2021 May 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539693/

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Brandon Kirsch, MD, FAAD, is a board-certified dermatologist specializing in clinical drug development and medical innovation. He is the founder of Kirsch Dermatology in Naples, Florida and is also the Chief of Dermatology at the Naples Community Hospital.

Hydroquinone Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Hydroquinone is used to lighten the dark patches of skin (also called hyperpigmentation, melasma, “liver spots,” “age spots,” freckles) caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. This medicine works by blocking the process in the skin that leads to discoloration.

How to use Hydroquinone Cream

Follow all directions on the product package, or use as directed by your doctor. Before using, apply a small amount of this medicine to an area of unbroken skin, and check the area within 24 hours for any serious side effects. If the test area is itching, red, puffy, or blistering, do not use this product and contact your doctor. If there is just mild redness, then treatment with this product may begin.

Apply this medication to the affected areas of skin, usually twice daily or as directed by your doctor. This medication is for use on the skin only. If it is used incorrectly, unwanted skin lightening may occur. Avoid getting this product in your eyes or on the inside of your nose or mouth. If you do get this medication in those areas, flush with plenty of water.

This medication may make the treated areas of skin more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing on the treated areas of skin when outdoors.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

Tell your doctor if your condition lasts or gets worse after 2 months.

Side Effects

See also How to Use.

Mild burning, stinging, redness, and dryness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop using hydroquinone and tell your doctor right away if you have any serious side effects, including: blistering, skin cracking, blue-black darkening of the skin.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using hydroquinone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, other skin conditions (such as eczema, psoriasis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Hydroquinone Cream interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms after swallowing may include: shaking (tremors), seizures.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another skin problem unless told to do so by your doctor. A different medication may be necessary in that case.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

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hydroquinone 4 % topical cream

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This medicine is a white, cream

hydroquinone 4 % topical cream

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This medicine is a white, cream

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

UK Dermatologists: Whitening creams act like a household solvent

September 28, 2019

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The British Local Government Association (LGA) has warned consumers about the dangers of using skin-whitening creams that act as a household paint remover.

This warning was issued after the association’s trade standards enforcement officers seized several batches of creams containing the bleaching ingredient hydroquinone and possibly also mercury.

According to the LGA, these toxic creams are available in the UK from hand, non-certified sellers, as well as online, at flea markets and flea markets.

Often, the exact composition of the ingredients is not indicated on the packaging of such products.

Why is hydroquinone dangerous?

Whitening creams are used to treat skin pigmentation, freckles, skin roughness, and often contain low doses of hydroquinone, but this component is toxic and affects the production of melanin, a pigment that protects the skin from harmful effects.

Due to serious side effects, creams containing hydroquinone, steroids or mercury are banned in the UK and can only be purchased with a doctor’s prescription.

British experts warn that hydroquinone acts on the skin in the same way as paint thinner, removing its top layer, which can lead to an increased risk of skin cancer, as well as liver and kidney failure.

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Mercury is just as dangerous and can cause the same health effects.

“Skin creams containing banned ingredients are very dangerous and can cause serious damage to your health, scarring and even death, and should never be used,” said LGA’s Simon Blackburn.

“Customers should always check what’s in a cream, be wary of too low a price – as it’s very likely to be counterfeit and potentially dangerous – and never use a product containing hydroquinone. If a product doesn’t list ingredients at all, then don’t use it,” Blackburn advised British consumers.

The British Skin Foundation takes the same advice, pointing out that the problem of illegal skin creams being sold on the black market recurs year after year.

“The ingredients in these beauty products can cause serious health problems, so the British Skin Foundation strongly discourages their use,” said Lisa Bickerstaff, spokesperson for the foundation.

Where were illegal creams seized?

The LGA has recently seized several shipments of whitening creams smuggled into the country, including:

• 360 items containing hydroquinone from a store in Dagenham, east London. Ingredients were incorrectly listed on the packages and did not meet EU standards. The shop owner was fined £6,500 ($7,300) and ordered to pay an additional £8,010 to the local council;
• in the London Borough of Sazark, local council officials withdrew 2,900 skin-whitening products from sale; most of them were imported in 2018 from Nigeria in a single batch;
• an illegal consignment from Cameroon containing 250 kg of bleaching creams containing hydroquinone was confiscated at London Gatwick Airport;
• in 2018, a store owner was sentenced to 20 months in prison for the first time in the UK for selling illegal whitening creams. The case was heard in the Royal Court of the Sazark district.

DERMAQUEST » Hydroquinone: what is it and why is it dangerous? | Rejuvenating peeling of the face against wrinkles | Reviews

What is dangerous whitening cream with hydroquinone, its action and side effects.

In your search for the most powerful pigment spot removal cream , you have come across information that is the most effective of all containing Hydroquinone.

But bad luck, it is impossible to buy a cream with hydroquinone in any official store, beauty salon or pharmacy.

What are the dangers of hydroquinone whitening cream, its effects and side effects.

CONTENT

• How hydroquinone works

• What is dangerous when applied topically

• Use of hydroquinone in different countries

• Modern alternative to hydroquinone

How hydroquinone works

It is a dihydric phenol, the molecules are very small and active. Easily penetrates into the deep layers of the skin.

Formerly used in medicine as an antiseptic and to reduce fever. But it was completely banned and withdrawn from medical use due to high toxicity.

In the skin, blocks the work of the tyrosinase enzyme, preventing the staining of keratinocytes with melanin pigment.

CONSULTANCY

Free online consultations are available from leading cosmetologists of the Russian representative office of DermaQuest / Circadia.

What is dangerous when applied topically

• Leads to death of skin pigment cells . The opposite result – in place of the former age spots appear white, discolored spots, as in vitiligo. The skin becomes defenseless against solar exposure, because. incapable of tanning.
• Increases the risk of developing skin cancer , which has a number of evidence-based studies. Especially dangerous is the use near the eyes – the development of pigmentation of the eyes and damage to the cornea were found.
• Destroys skin collagen , provokes the appearance of early wrinkles, thinning and aging of the skin.

Hydroquinone use in different countries

Surprisingly, topical hydroquinone still exists officially in a number of countries:

Approved for use in Russia and China;

Completely banned – USA, Japan, European Union;

Other countries – partial use – in concentrations up to 2%.

In countries with a high standard of living, hydroquinone is completely banned from use, based on official studies on the harm and toxicity of exposure to the skin.

Important! Before performing a professional procedure, the beautician should be informed about the use of products with hydroquinone, because. such skin has increased sensitivity, thinned epidermis and poor regenerative abilities. The restoration of the skin and its reaction to the procedure may come as a surprise to the specialist if the information has been hidden.

A modern alternative to hydroquinone

Science does not stand still, today there are modern safe substances that have many times more activity in comparison with outdated Hydroquinone, and at the same time – completely non-toxic! The list of safe whitening ingredients is long enough. However, their effectiveness is not always comparable with hydroquinone.

The main secret is the choice of product with combination of brightening ingredients .

The most effective and safe to use are:

1. Retinoids – naturally normalize the work of pigment cells, leading to lightening of pigmentation.
2. Hexylresorcinol – a tyrosinase inhibitor, as part of the patented Synovea® HR complex, whitening efficiency is 4 times higher than that of 2% hydroquinone!

DermaQuest professional medical cosmetics for clinics and beauty salons made in the USA has developed a special line “SkinBright” based on the richest complex of modern active ingredients, exceeding the result of 2% Hydroquinone by 4 times!

A powerful combination of whitening ingredients found in Brighting Retinol Serum DermaQuest – effective whitening of all types of age spots, incl.