About all

Hydroxychloroquine sulfate 200: Hydroxychloroquine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Hydroxychloroquine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Hydroxychloroquine is used to prevent or treat malaria caused by mosquito bites. The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs.This medication is also used to treat certain auto-immune diseases (lupus, rheumatoid arthritis). It belongs to a class of medications known as disease-modifying antirheumatic drugs (DMARDs). It can reduce skin problems in lupus and prevent swelling/pain in arthritis.Hydroxychloroquine is not recommended for coronavirus infection, also known as COVID-19, unless you are enrolled in a study. Talk to your doctor about the risks and benefits.

How to use Hydroxychloroquine SULFATE

Take this medication by mouth exactly as directed by your doctor. To help prevent stomach upset, take it with food or milk. Swallow the tablets whole since breaking or crushing them may leave a bitter taste. The dosage and length of treatment are based on your medical condition and response to treatment. Children’s dose is also based on weight.

To prevent malaria, take this medication by mouth as directed by your doctor, usually once a week on the same day each week. Mark a calendar to help you remember. This drug is usually started 1 to 2 weeks before entering the malarious area. Continue to take it weekly while in the area and for 4 to 8 weeks after leaving the area, or as directed by your doctor. To treat malaria, follow your doctor’s instructions.

For lupus or rheumatoid arthritis, take this medication by mouth as directed by your doctor, usually once or twice daily. Your doctor may gradually increase your dose. Once you have been taking the medication for a while and your condition has improved, your doctor may instruct you to lower your dose until you find the dose that works best with the fewest side effects.

If you are also taking a certain drug for diarrhea (kaolin) or taking antacids (such as magnesium/aluminum hydroxide), take hydroxychloroquine at least 4 hours before or after these products. These products may bind with hydroxychloroquine, preventing your body from fully absorbing it.

Use this medication regularly in order to get the most benefit from it. If you are taking it on a daily schedule, take it at the same time(s) each day. Take this medication exactly as prescribed. Do not stop taking it without talking with your doctor, especially if you are taking it for malaria. It is important to continue taking this for the length of time prescribed. Stopping prevention or treatment too soon may lead to infection or a return of the infection.

Tell your doctor if your condition lasts or gets worse. It may take several weeks or months to see improvement if you are taking this for lupus or arthritis. Hydroxychloroquine may not prevent malaria in all cases. If you experience fever or other symptoms of illness, get medical help right away (especially while in the malarious area and for 2 months after returning from the area). You may need a different medication. Avoid exposure to mosquitoes. (See also Notes section.

Side Effects

Nausea, vomiting, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: slow heartbeat, symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), mental/mood changes (such as anxiety, depression, rare thoughts of suicide, hallucinations), hearing changes (such as ringing in the ears, hearing loss), easy bruising/bleeding, signs of liver disease (such as severe stomach/abdominal pain, yellowing eyes/skin, dark urine), signs of kidney problems (such as change in the amount of urine), muscle weakness, unwanted/uncontrolled movements (including tongue/face twitching), hair loss, hair/skin color changes.

This medication may cause low blood sugar (hypoglycemia). Tell your doctor right away if you develop symptoms of low blood sugar, such as sudden sweating, shaking, hunger, blurred vision, dizziness, or tingling hands/feet. If you have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication.

Get medical help right away if you have any very serious side effects, including: severe dizziness, fainting, fast/irregular heartbeat, seizures.

This medication may cause serious eye/vision problems. The risk for these side effects is increased with long-term use of this medication and with taking this medication in high doses. Get medical help right away if you have any symptoms of serious eye problems, including: sensitivity to light, vision changes (such as light flashes/streaks, blurred vision, difficulty reading, missing areas of vision).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking hydroxychloroquine, tell your doctor or pharmacist if you are allergic to it; or to chloroquine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain enzyme problem (glucose-6-phosphate dehydrogenase deficiency-G6PD), vision/eye problems, hearing problems, kidney disease, liver disease, regular alcohol use/abuse, skin problems (such as psoriasis), a certain blood disorder (porphyria), seizures.

If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of low blood sugar (see Side Effects section). Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Alcohol can also increase your risk of liver problems while you are taking this drug.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Hydroxychloroquine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using hydroxychloroquine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using hydroxychloroquine safely.

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: penicillamine, remdesivir.

Many drugs besides hydroxychloroquine may affect the heart rhythm (QT prolongation), including amiodarone, azithromycin, disopyramide, dronedarone, pimozide, quinidine, among others.

Does Hydroxychloroquine SULFATE interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast/irregular heartbeat, fainting, slow/shallow breathing, seizures.

Do not share this medication with others.

Lab and/or medical tests (such as eye exams, reflex tests, liver/kidney function, EKG, complete blood counts) should be done if you are taking hydroxychloroquine for a long time. Keep all medical and lab appointments. Consult your doctor for more details.

When traveling in an area at risk for malaria, use protective clothing, insect repellent, and bed nets. Remain indoors or in well-screened areas when possible. If you are taking this medication to prevent or treat malaria, use it for your current travel or condition only. Do not use it later to prevent or treat another infection unless your doctor tells you to.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from moisture and light. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

hydroxychloroquine 200 mg tablet

Color: whiteShape: roundImprint: 347

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: off-whiteShape: roundImprint: GG 260

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: roundImprint: M 373

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: ZC38

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: HCQS

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: AC54

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: ZC38

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: A 19

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: L7

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: double-circleImprint: PLAQUENIL

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: peanutImprint: h21

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: ovalImprint: 698 200 WATSON

This medicine is a white, round, film-coated, tablet imprinted with “347”.

hydroxychloroquine 200 mg tablet

Color: whiteShape: oblongImprint: AC 384

This medicine is a white, round, film-coated, tablet imprinted with “347”.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Hydroxychloroquine Interactions – Drugs.com

Print

Save

There are 453 drugs known to interact with
hydroxychloroquine, along with
13 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
185 are major, 264 are moderate, and 4 are minor.

Does hydroxychloroquine interact with my other drugs?

Enter other medications to view a detailed report.

  • View all 453 medications that may interact with hydroxychloroquine
  • View hydroxychloroquine alcohol/food interactions (1)
  • View hydroxychloroquine disease interactions (13)

Most frequently checked interactions

View interaction reports for hydroxychloroquine and the medicines listed below.

  • Major
  • Moderate
  • Minor
  • Unknown
  • Adderall (amphetamine / dextroamphetamine)
  • Aspir 81 (aspirin)
  • Aspirin Low Strength (aspirin)
  • azithromycin
  • Benadryl (diphenhydramine)
  • Calcium 600 D (calcium / vitamin d)
  • Celebrex (celecoxib)
  • CoQ10 (ubiquinone)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • Eliquis (apixaban)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • Humira (adalimumab)
  • Iron Sulfate (ferrous sulfate)
  • Lyrica (pregabalin)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • Nexium (esomeprazole)
  • Norco (acetaminophen / hydrocodone)
  • Singulair (montelukast)
  • Symbicort (budesonide / formoterol)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zinc (zinc sulfate)
  • Zyrtec (cetirizine)

Hydroxychloroquine alcohol/food interactions

There is 1 alcohol/food interaction with hydroxychloroquine.

Hydroxychloroquine disease interactions

There are 13 disease interactions with hydroxychloroquine which include:

  • oculotoxicity
  • porphyria
  • arrhythmias
  • bone marrow suppression
  • ototoxicity
  • seizures
  • glucose-6-PD deficiency
  • hepatotoxicity
  • myasthenia gravis
  • psoriasis
  • diabetes
  • heart disease
  • renal impairment

Report options

Loading…

QR code containing a link to this page

More about hydroxychloroquine

  • hydroxychloroquine consumer information
  • Compare alternatives
  • Pricing & coupons
  • Reviews (347)
  • Drug images
  • Latest FDA alerts (2)
  • Side effects
  • Dosage information
  • During pregnancy
  • Support group
  • Drug class: antimalarial quinolines
  • Breastfeeding
  • En español

Related treatment guides

  • Lyme Disease, Arthritis
  • Dermatomyositis
  • Lichen Planopilaris
  • Malaria

Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances.
MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
UnknownNo interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

About the use of Hydroxychloroquine in the treatment of patients with coronavirus infection

sent successfully. Thanks for your feedback!


There are currently no registered antiviral drugs in the world that are indicated for use in SARS-COV2 infection.
Several drugs are being used to treat patients with COVID-19 that have been shown to target different parts of the infection process in experimental or limited clinical trials.
These drugs include Hydroxychloroquine (hereinafter referred to as HCQ), which, due to its anti-inflammatory effect and effect on the immune system, has been used for decades to treat malaria, rheumatoid arthritis, and systemic lupus erythematosus.
Recommendations for the use of HCC in COVID-19 are based on the results of numerous foreign studies that confirmed the effectiveness of the drug against an infectious agent in vitro (in the experiment), and then in clinical trials, as well as expert opinions.
These data, supported by the experience of using HCC in real practice around the world, were the basis for its inclusion in a number of national and international clinical guidelines, including in our country.
HCQ hydroxychloroquine has side effects, in particular, among which one of the most significant is cardiotoxicity (the ability to cause heart rhythm disturbances).
For this reason, the Interim Guidelines for Prevention, Diagnosis and Treatment of Novel Coronavirus Infection (COVID-19), approved on 04/28/2020, provide guidance on monitoring heart rate in patients receiving HCC, as well as preventing its use in patients at high risk of developing arrhythmias.
Considering that HCQ, like other drugs for the treatment of COVID-19, do not have registered indications for the treatment of coronavirus infection, patients to whom they are prescribed give informed consent to the use of these drugs.
According to the results of monitoring the safety of hydroxychloroquine drugs during the COVID-19 pandemic in the Russian Federation, there were no deaths associated with arrhythmias in patients treated with HCQ.
The Ministry of Health of Russia has all the latest data on the efficacy and safety of drugs used in the treatment of COVID-19. This information is used to update Russian clinical guidelines for the management of patients with COVID-19.
The WHO decision of May 26, 2029 to suspend clinical trials of HCC under the Solidarity program to further assess its safety is based on evidence of cardiotoxicity, which, in hospitalized patients with a high incidence of comorbidities, can lead to life-threatening cardiac arrhythmias.
At the same time, a significant array of published results of foreign studies, as well as domestic experience, indicates the validity of the use of HCQ when prescribed in certain groups of patients with COVID-19.at low doses, less associated with cardiac arrhythmias.
The Ministry of Health of Russia is completing the preparation of the seventh version of the Interim Guidelines for the Diagnosis, Prevention and Treatment of COVID-19. They will include additional criteria for clinicians to assess the benefits and risks of using HHC on a patient-by-patient basis in order to decide whether to prescribe it, detailed guidelines for its use in patients at low risk of arrhythmias, and measures to monitor and prevent arrhythmias during treatment.
The issue of the effectiveness and safety of hydroxychloroquine, as well as other drugs used in Russia for the treatment of COVID-19, is under the constant control of the Russian Ministry of Health and its subordinate organizations.

Categories: coronavirus.

Hydroxychloroquine for Covid-19: WHO Suspends Trump Drug Trials (article contains disclaimer) sign up for our newsletter “Context”: it will help you understand the events.

Image copyright, Getty Images

Image caption,

To date, there is no conclusive evidence that hydroxychloroquine or drugs of similar effect can prevent infection with coronavirus, although clinical trials in this direction are underway in a number of countries, in particular in the United States, UK, Spain and China.

BBC Russian Service: 10 days after the publication of this article, the prestigious medical journal Lancet, on whose research this material was based, refuted its previous conclusions. It turned out that the data underlying the Lancet publication was provided by an unknown small company, Surgisphere, and is probably incorrect.

British newspaper Guardian ‘s own investigation revealed that Surgisphere employs only a few dozen employees, including a science fiction writer and an adult film actress. The quality of the research after that raised doubts among journalists.

The WHO, which suspended trials of hydroxyloroquine following the Lancet’s publication, said it was ready to continue. Also resuming t dozens of other tests. The Russian service of the BBC continues to monitor the development of the situation.

On May 25, the World Health Organization suspended clinical trials of hydroxychloroquine and chloroquine as a potential treatment for Covid-19 due to safety concerns. A recent study showed that the use of hydroxyloroquine is not only ineffective, but may increase the likelihood of a patient’s death.

After analyzing the data 96 thousand patients from 671 hospitals around the world, scientists came to the conclusion that chloroquine and its derivative, hydroxyloroquine, are potentially dangerous in that they can cause complications from the cardiovascular system. The risk of developing cardiac arrhythmia in those taking the antimalarial drug was markedly increased.

Some time ago, US President Donald Trump announced that he was taking hydroxychloroquine as a preventive measure to avoid infection, despite the statements of the World Health Organization that there was no conclusive evidence of the effectiveness of the drug in the fight against coronavirus.

  • Scientists close clinical trials of remdesivir for Covid-19
  • Anti-malaria drug against Covid-19: how effective is hydroxychloroquine?

On Sunday, Trump announced that he had drunk a two-week course and was no longer taking the drug. “And by the way, I’m still here,” Trump said in an interview with the Sinclair Broadcasting network. The use of drugs for the treatment of coronavirus was also praised by Brazilian President Jair Bolsonaro.

The World Health Organization has previously warned against the use of the drug except in clinical trials, and now it has temporarily suspended them altogether until the drug safety executive group examines all currently available materials.

While added to the WHO, chloroquine and hydroxychloroquine are still safe for treating malaria and some autoimmune diseases.

Since the start of the coronavirus pandemic last year, nearly 345,000 people have died and almost 5.5 million people have been infected. Scientists around the world are trying to find a cure for Covid-19 or develop a vaccine that would ease quarantine measures, including social distancing.

  • Coronavirus: what vaccines and tests are being tested around the world

The WHO warns that the pandemic has not subsided and that countries still need to beware of an increase in cases. “Everyone should be on the lookout. The virus will return as soon as possible,” said WHO epidemiologist Maria Van Kerkhove.

Image copyright, Getty

Image caption,

Chloroquine and its derivatives are commonly prescribed to treat malaria

Skip the Podcast and continue reading.

Podcast

What was that?

We quickly, simply and clearly explain what happened, why it is important and what will happen next.

episodes

End of story Podcast

Hydroxychloroquine is a more recent and less toxic version of the chloroquine drug and has more pronounced antiviral and anti-inflammatory effects.

Chloroquine is commonly prescribed to treat malaria, certain protozoal infections, rheumatoid arthritis, and lupus erythematosus.

Both of these drugs are cardiotoxic and can cause arrhythmia and tachycardia, especially in patients with pre-existing cardiovascular disease – as previously warned by the US Food and Drug Administration (FDA) in connection with the use of these two drugs for the treatment Covid-19on an outpatient basis or during clinical trials.

A study published last week in the Lancet suggested that the use of the drug alone or in combination with antibiotics may increase the risk of death from coronavirus.

Scientists analyzed the data and treatments of 96,000 coronavirus patients from 671 hospitals around the world and compared the data of patients in three groups. In the first group, data were collected from patients who were treated with one of the antimalarial drugs, and in the second, data from patients who were given an antimalarial drug in combination with an antibiotic. The third group – the control group – consisted of patients who were not given medication. The conclusion reached by the doctors was that patients who took the drugs had a higher risk of dying.

Mortality in the control group was 9.3%, mortality in the drug groups ranged from 16 to 23.8% (in the hydroxychloroquine group – 18%, in the chloroquine group – 16.4%, in the group taking both drugs and antibiotics – 22.