About all

Ic penicillin vk 500 mg. Penicillin V: Uses, Dosage, Side Effects, and Interactions

What is Penicillin V used for. How does Penicillin V work. What are the common side effects of Penicillin V. How does Penicillin V interact with other medications.

Содержание

Understanding Penicillin V: A Powerful Antibiotic

Penicillin V, also known as phenoxymethylpenicillin, is a widely prescribed antibiotic medication. It belongs to the penicillin class of antibiotics and is used to treat various bacterial infections. This oral medication is available as both tablets and a solution, making it versatile for different patient needs.

What is Penicillin V?

Penicillin V is a beta-lactam antibiotic that works by inhibiting bacterial cell wall synthesis. It’s effective against many gram-positive and some gram-negative bacteria. The drug is only available as a generic medication, which often makes it a cost-effective treatment option for many patients.

The Mechanism of Action: How Penicillin V Fights Infections

How does Penicillin V combat bacterial infections? This antibiotic works by interfering with the bacteria’s ability to form cell walls, which are crucial for their survival and reproduction. By disrupting this process, Penicillin V effectively stops the bacteria from multiplying, ultimately leading to their destruction.

The Science Behind Penicillin V’s Effectiveness

Penicillin V targets the peptidoglycan layer of bacterial cell walls. This layer is essential for maintaining the structural integrity of the bacteria. By binding to penicillin-binding proteins (PBPs) in the bacterial cell wall, Penicillin V prevents the cross-linking of peptidoglycan strands, weakening the cell wall and causing the bacteria to burst due to osmotic pressure.

Common Uses of Penicillin V: Treating Various Bacterial Infections

Penicillin V is prescribed for a range of bacterial infections. Its effectiveness against specific bacteria makes it a go-to choice for certain conditions. Here are some of the primary uses of Penicillin V:

  • Streptococcal infections of the upper respiratory tract
  • Scarlet fever
  • Erysipelas infections
  • Pneumococcal upper respiratory infections
  • Staphylococcal skin and soft tissue infections
  • Fusospirochetosis (infection of the oropharynx)
  • Prevention of rheumatic fever and chorea

Is Penicillin V effective against viral infections? No, it’s important to note that Penicillin V is not effective against viral infections such as the common cold or flu. It’s specifically designed to combat bacterial infections.

Dosage and Administration: Ensuring Proper Use of Penicillin V

The dosage of Penicillin V can vary depending on the type and severity of the infection being treated. It’s typically available in 250 mg and 500 mg tablets, as well as an oral solution for those who have difficulty swallowing pills.

Typical Dosing Guidelines

While exact dosages should always be determined by a healthcare provider, here are some general guidelines:

  • For adults: 250-500 mg every 6-8 hours
  • For children: Based on body weight, typically 25-50 mg/kg/day divided into 3-4 doses

How long should you take Penicillin V? The duration of treatment usually ranges from 7 to 10 days, but can be longer for certain infections. It’s crucial to complete the entire course of antibiotics as prescribed, even if symptoms improve before the medication is finished.

Side Effects: What to Expect When Taking Penicillin V

Like all medications, Penicillin V can cause side effects. While many people tolerate it well, it’s important to be aware of potential adverse reactions. Common side effects of Penicillin V include:

  • Nausea
  • Vomiting
  • Stomach upset
  • Diarrhea
  • Black hairy tongue (a harmless condition that resolves after stopping the medication)

These side effects are usually mild and often resolve on their own. However, if they persist or worsen, it’s important to consult with a healthcare provider.

Serious Side Effects to Watch For

While rare, some people may experience more serious side effects that require immediate medical attention. These can include:

  • Allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
  • Severe diarrhea (watery or bloody)
  • Signs of a new infection (fever, persistent sore throat)

Can Penicillin V cause anaphylaxis? Yes, in rare cases, Penicillin V can cause a severe allergic reaction known as anaphylaxis. This is a medical emergency that requires immediate treatment.

Drug Interactions: Ensuring Safe Use of Penicillin V

Penicillin V can interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking before starting Penicillin V.

Common Drug Interactions

Some medications that may interact with Penicillin V include:

  • Probenecid (can increase Penicillin V levels in the body)
  • Methotrexate (Penicillin V may increase its toxicity)
  • Oral contraceptives (Penicillin V may reduce their effectiveness)
  • Certain antibiotics (may reduce the effectiveness of Penicillin V)

How can you minimize the risk of drug interactions? Always provide your healthcare provider with a complete list of your medications and follow their guidance on timing and dosage.

Special Considerations: Penicillin V in Specific Populations

While Penicillin V is generally safe for most people, certain groups may require special consideration or monitoring when using this antibiotic.

Pregnancy and Breastfeeding

Penicillin V is considered safe for use during pregnancy and breastfeeding. However, it’s always important to discuss the potential risks and benefits with a healthcare provider before using any medication during these times.

Elderly Patients

Older adults may be more sensitive to the effects of Penicillin V and may require dose adjustments. Kidney function should be monitored in elderly patients taking this medication.

Patients with Allergies

Individuals with a history of allergic reactions to penicillins or other beta-lactam antibiotics should use Penicillin V with caution or avoid it altogether. A thorough allergy history should be taken before prescribing this medication.

Antibiotic Resistance: The Importance of Proper Use

Antibiotic resistance is a growing concern in healthcare. The misuse and overuse of antibiotics like Penicillin V can contribute to the development of resistant bacteria, making infections harder to treat.

Preventing Antibiotic Resistance

To help prevent antibiotic resistance:

  • Only use antibiotics when prescribed by a healthcare provider
  • Complete the full course of antibiotics as prescribed
  • Do not save antibiotics for later use or share them with others
  • Practice good hygiene to prevent the spread of infections

How does antibiotic resistance develop? Bacteria can develop resistance through genetic mutations or by acquiring resistance genes from other bacteria. When exposed to antibiotics, resistant bacteria survive and reproduce, passing on their resistance to future generations.

Alternatives to Penicillin V: Options for Those with Allergies or Resistance

While Penicillin V is an effective antibiotic for many infections, there are cases where alternative treatments may be necessary. This could be due to allergies, antibiotic resistance, or the specific type of infection being treated.

Common Alternatives to Penicillin V

Some alternative antibiotics that may be used in place of Penicillin V include:

  • Amoxicillin
  • Cephalosporins
  • Macrolides (e.g., erythromycin, azithromycin)
  • Fluoroquinolones
  • Tetracyclines

The choice of alternative antibiotics depends on various factors, including the type of infection, local resistance patterns, and individual patient characteristics.

How do healthcare providers choose an alternative antibiotic? They consider factors such as the suspected or confirmed pathogen, the site of infection, the patient’s allergy history, and local antibiotic resistance patterns.

The Future of Antibiotics: Ongoing Research and Development

As antibiotic resistance continues to pose challenges in healthcare, research into new antibiotics and alternative treatments is ongoing. Scientists are exploring various approaches to combat bacterial infections and overcome resistance.

Promising Areas of Research

Some of the innovative approaches being studied include:

  • Development of new classes of antibiotics
  • Combination therapies to enhance antibiotic effectiveness
  • Bacteriophage therapy
  • Immunotherapies to boost the body’s natural defenses
  • Nanotechnology-based antibiotic delivery systems

What role will Penicillin V play in future antibiotic treatments? While newer antibiotics are being developed, Penicillin V is likely to remain an important tool in treating certain bacterial infections, particularly those caused by susceptible strains of streptococci and other sensitive organisms.

As we continue to face challenges in treating bacterial infections, the responsible use of antibiotics like Penicillin V, along with ongoing research and development, will be crucial in maintaining our ability to effectively combat these pathogens. By understanding the proper use, benefits, and limitations of antibiotics, we can all play a part in preserving their effectiveness for future generations.

Penicillin V | Side Effects, Dosage, Uses, and More

Penicillin V | Side Effects, Dosage, Uses, and More

  • Health Conditions
    • Featured
      • Breast Cancer
      • IBD
      • Migraine
      • Multiple Sclerosis (MS)
      • Rheumatoid Arthritis
      • Type 2 Diabetes
    • Articles
      • Acid Reflux
      • ADHD
      • Allergies
      • Alzheimer’s & Dementia
      • Bipolar Disorder
      • Cancer
      • Crohn’s Disease
      • Chronic Pain
      • Cold & Flu
      • COPD
      • Depression
      • Fibromyalgia
      • Heart Disease
      • High Cholesterol
      • HIV
      • Hypertension
      • IPF
      • Osteoarthritis
      • Psoriasis
      • Skin Disorders and Care
      • STDs
  • Discover
    • Wellness Topics
      • Nutrition
      • Fitness
      • Skin Care
      • Sexual Health
      • Women’s Health
      • Mental Well-Being
      • Sleep
    • Product Reviews
      • Vitamins & Supplements
      • Sleep
      • Mental Health
      • Nutrition
      • At-Home Testing
      • CBD
      • Men’s Health
    • Original Series
      • Fresh Food Fast
      • Diagnosis Diaries
      • You’re Not Alone
      • Present Tense
    • Video Series
      • Youth in Focus
      • Healthy Harvest
      • No More Silence
      • Future of Health
  • Plan
    • Health Challenges
      • Mindful Eating
      • Sugar Savvy
      • Move Your Body
      • Gut Health
      • Mood Foods
      • Align Your Spine
    • Find Care
      • Primary Care
      • Mental Health
      • OB-GYN
      • Dermatologists
      • Neurologists
      • Cardiologists
      • Orthopedists
    • Lifestyle Quizzes
      • Weight Management
      • Am I Depressed? A Quiz for Teens
      • Are You a Workaholic?
      • How Well Do You Sleep?
    • Tools & Resources
      • Health News
      • Find a Diet
      • Find Healthy Snacks
      • Drugs A-Z
      • Health A-Z
  • Connect
      • Breast Cancer
      • Inflammatory Bowel Disease
      • Psoriatic Arthritis
      • Migraine
      • Multiple Sclerosis
      • Psoriasis

Medically reviewed by University of Illinois — By University of Illinois — Updated on November 20, 2018

Highlights for penicillin V

  1. Penicillin V oral tablet is only available as a generic drug.
  2. Penicillin V also comes as an oral solution.
  3. Penicillin V oral tablet is used to treat certain infections caused by bacteria. It won’t work for infections caused by viruses, such as the common cold.

Penicillin V is a prescription drug that comes as an oral tablet and an oral solution.

Penicillin V oral tablet is only available as a generic drug.

Why it’s used

Penicillin V oral tablet is used to treat certain infections caused by bacteria. It won’t work to treat infections caused by viruses, such as the common cold. Bacterial infections this drug is used to treat include:

  • streptococcal upper respiratory tract infections, scarlet fever, and erysipelas infections
  • pneumococcal upper respiratory infections
  • staphylococcal skin and soft tissue infections
  • fusospirochetosis (infection of the oropharynx or middle part of the throat)
  • prevention of rheumatic fever and chorea

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

How it works

Penicillin V belongs to a class of drugs called antibiotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Penicillin V works by stopping the bacteria from multiplying. This kills off the bacteria that are causing your infection.

Penicillin V oral tablet doesn’t cause drowsiness. However, it may cause other side effects.

More common side effects

The more common side effects of penicillin V can include:

  • nausea
  • vomiting
  • stomach upset
  • diarrhea
  • black hairy tongue

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Allergic reaction. Symptoms can include:
    • skin rash with or without blisters
    • flu-like symptoms, such as a fever, feeling ill, or joint pain
    • swelling of your throat, tongue, or mouth
  • Diarrhea. Symptoms include:
    • bloody or watery diarrhea with or without stomach cramps and a fever

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Penicillin V oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help prevent interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This dosage information is for penicillin V oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • the severity of your condition
  • other medical conditions you have
  • how you react to the first dose

Forms and strengths

Generic: Penicillin V

  • Form: Oral tablet
  • Strengths: 250 mg, 500 mg

Dosage for streptococcal infection

Adult dosage (ages 18 years and older)

  • Typical dosage: 125–250 mg taken every 6–8 hours for 10 days.

Child dosage (ages 12–17 years)

  • Typical dosage: 125–250 mg taken every 6–8 hours for 10 days.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years.

Dosage for pneumococcal upper respiratory infection

Adult dosage (ages 18 years and older)

  • Typical dosage: 250–500 mg taken every 6 hours until you no longer have a fever for at least 2 days.

Child dosage (ages 12–17 years)

  • Typical dosage: 250–500 mg taken every 6 hours until you no longer have a fever for at least 2 days.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years.

Dosage for staphylococcal skin or soft tissue infection

Adult dosage (ages 18 years and older)

  • Typical dosage: 250–500 mg taken every 6–8 hours.

Child dosage (ages 12–17 years)

  • Typical dosage: 250–500 mg taken every 6–8 hours.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years.

Dosage for prevention of rheumatic fever or chorea or both

Adult dosage (ages 18 years and older)

  • Typical dosage: 125–250 mg taken two times per day.

Child dosage (ages 12–17 years)

  • Typical dosage: 125–250 mg taken two times per day.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years.

Dosage for fusospirochetosis (oropharynx infection)

Adult dosage (ages 18 years and older)

  • Typical dosage: 250–500 mg taken every 6–8 hours.

Child dosage (ages 12–17 years)

  • Typical dosage: 250–500 mg taken every 6–8 hours.

Child dosage (ages 0–11 years)

It hasn’t been confirmed that this drug is safe and effective for use in people younger than 12 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Penicillin V oral tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your infection may not get better or may get worse. Even if you’re starting to feel better, you should still finish all of your medication.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of this drug in your body. Symptoms of an overdose of this drug can include:

  • Diarrhea
  • Nausea
  • Oral infection. Symptoms can include:
    • creamy white lesions that look like cottage cheese
    • cotton mouth (dry mouth)
  • Vomiting
  • Blackened tongue

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 1-800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: Your symptoms and your infection should get better.

As with all medications, the costs of penicillin V can vary.

Keep these considerations in mind if your doctor prescribes penicillin V oral tablet for you.

General

Do not take this drug with food. Take it on an empty stomach, at least 1 hour before eating or 2 hours after eating.

You can cut or crush the tablet.

Storage

  • Store this drug at room temperature. Keep it between 68°F and 77°F (15°C and 30°C).
  • Keep the container tightly closed.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

Your doctor may do blood tests to check how well your kidneys are working. If your kidneys aren’t working well, your doctor may lower your dose of this drug.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

  • Serious allergic reaction warning: This drug can cause a severe allergic reaction. Symptoms include a skin rash with or without blisters, flu-like symptoms (such as a fever, feeling ill, or joint pain), or swelling of your throat, tongue, or mouth. If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it.
  • Severe diarrhea warning: This drug may cause diarrhea during and after your treatment with it. This diarrhea can be caused by an infection in your intestine called Clostridium difficile. Call your doctor right away if you have bloody or watery diarrhea with or without stomach cramps and a fever while you’re taking this drug.
  • Prescription completion warning: It’s important you finish all of your penicillin V prescription even if you’re feeling better. If you skip doses or don’t complete the full course of treatment, this drug won’t work as well. Also, the bacteria causing your infection may become resistant to treatment. Resistance means that it won’t respond to penicillin V or other antibiotics in the future.

Allergy warning

Penicillin V can cause a severe allergic reaction. Symptoms can include:

  • skin rash with or without blisters
  • flu-like symptoms, such as a fever, feeling ill, or joint pain
  • swelling of your throat, tongue, or mouth

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it or any other type of penicillin. Taking it again could be fatal (cause death).

If you have severe allergies, you have a higher risk of developing a severe allergic reaction to penicillin. This type of allergic reaction is called anaphylaxis. Symptoms can include throat swelling, trouble swallowing, wheezing, and trouble breathing.

Warnings for people with certain health conditions

For people with asthma: If you have asthma, you have a higher risk of developing a severe allergic reaction to penicillin. This type of allergic reaction is called anaphylaxis. Symptoms can include throat swelling, trouble swallowing, wheezing, and trouble breathing.

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of penicillin V in your body and cause more side effects.

Warnings for other groups

For pregnant women: The Food and Drug Administration (FDA) hasn’t assigned a pregnancy category to penicillin V. It is not yet known if penicillin V is safe and effective for use in pregnant women. Tell your doctor if you’re pregnant or plan to become pregnant. Penicillin V should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

For women who are breastfeeding: Penicillin V may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This drug hasn’t been studied in children. It shouldn’t be used in people younger than 12 years of age.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Last medically reviewed on May 21, 2018

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • Penicillin V potassium – penicillin v potassium tablet, film coated. (2017).
    dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cfc0df21-fb6f-447d-96f6-f851732f9e2f
  • Penicillin V potassium – penicillin v potassium tablet; Penicillin V potassium- penicillin V potassium for solution. (2014).
    dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6417642-66c5-48b5-86bf-ffb87c4250ac

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

Nov 20, 2018

Written By

University of Illinois-Chicago

Edited By

Frank Crooks

May 21, 2018

Medically Reviewed By

University of Illinois-Chicago

Share this article

Medically reviewed by University of Illinois — By University of Illinois — Updated on November 20, 2018

related stories

  • Amoxicillin vs. Penicillin: What’s the Difference?

  • Side Effects of Antibiotics: What They Are and How to Manage Them

  • What You Should Eat During and After Antibiotics

  • Streptococcal Screen

  • Strep Throat Prevention and Treatment

Read this next

  • Amoxicillin vs. Penicillin: What’s the Difference?

    Medically reviewed by Alan Carter, Pharm.D.

    Learn about amoxicillin and penicillin, the conditions they’re used to treat, and how these drugs are different.

    READ MORE

  • Side Effects of Antibiotics: What They Are and How to Manage Them

    Medically reviewed by Alan Carter, Pharm. D.

    Antibiotics are prescription drugs that help treat infections. Some of the more common infections treated with antibiotics include bronchitis…

    READ MORE

  • What You Should Eat During and After Antibiotics

    By Ruairi Robertson, PhD and Alina Sharon

    Antibiotics can cause side effects like diarrhea and changes to the gut microbiota, but luckily, certain foods can reduce the risk. Here’s what to eat…

    READ MORE

  • Streptococcal Screen

    Medically reviewed by Stacy Sampson, D.O.

    READ MORE

  • Strep Throat Prevention and Treatment

    Medically reviewed by Deborah Weatherspoon, Ph.D., MSN

    Strep throat is highly contagious and can lead to serious complications. Learn how to avoid, recognize, and treat strep throat.

    READ MORE

  • 5 Tips for Preventing Pneumonia

    Pneumonia can develop from an upper respiratory infection or following a surgical procedure. Here are 5 tips to help you prevent this condition.

    READ MORE

  • How Do Antibiotics Work?

    Medically reviewed by Alan Carter, Pharm. D.

    Antibiotics are powerful, lifesaving medications used to fight infections caused by bacteria. Learn more here.

    READ MORE

  • Can You Drink Alcohol While Taking Doxycycline?

    Medically reviewed by Femi Aremu, PharmD

    Should you drink alcohol while taking the popular antibiotic doxycycline? What will happen if you do? Get answers to these and other questions about…

    READ MORE

  • What Happens When Bacteria Become Resistant to Antibiotics

    Antibiotic resistance refers to bacteria that are no longer contained or killed by antibiotics. We explain why this is a problem and what we can do…

    READ MORE

  • What Are the Signs That You Should See a Doctor After Ankle Surgery?

    Complications may occur after ankle surgery, and these include infections, bone fractures, and persistent pain.

    READ MORE

Pen-VK – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Penicillin belongs to the family of medications known as antibiotics. Penicillin is used to treat infections caused by certain bacteria. It is most commonly used to treat certain throat, respiratory tract, and skin infections. It may be used to prevent certain infections in people whose bodies areunable to fight infections. It works by killing or preventing the growth of bacteria that cause the infection.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each orange, film-coated, round, biconvex tablet, scored and engraved “300” on one side and plain on the other side, contains 300 mg of penicillin V potassium (equivalent to 480,000 IU). Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, FD&C Yellow No. 10 Aluminum Lake, hydroxypropyl cellulose, magnesium stearate, methylcellulose, polyethylene glycol, purified water, sunset yellow aluminum lake, and titanium dioxide.

How should I use this medication?

The recommended dose of penicillin for adults and children varies according to the infection being treated. The recommended dose for adults and children over 12 years old ranges from 1 to 4 grams daily, divided into 3 to 4 doses.

The dose for children under 12 years old is based on body weight. The recommended daily dose ranges from 25 mg to 100 mg per kg of body weight and is divided into 3 or 4 equal doses.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

When taken by mouth, penicillin should be taken on an empty stomach, either 1 hour before or 2 hours after meals.

Finish all this medication, even if you have started to feel better. This will reduce the chance of the infection returning.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.  If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to penicillin or any ingredients of the medication
  • have certain types of severe infections

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • black hairy tongue
  • bloating
  • diarrhea
  • heartburn
  • nausea
  • skin rash
  • stomach pains
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • fever, itchy skin, muscle pain, swollen glands, general feeling of being unwell
  • numbness or weakness in the extremities
  • signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of clotting problems (e. g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of liver problems, e.g.:
    • dark urine
    • diarrhea
    • loss of appetite
    • nausea
    • pale stools
    • vomiting
    • weight loss
    • yellowing of the skin or whites of the eyes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • diarrhea (watery and severe; may also be bloody)
  • fever that appears after starting the antibiotic
  • seizures
  • signs of a serious allergic reaction, e.g.:
    • abdominal cramps
    • difficulty breathing
    • nausea and vomiting
    • swelling of the face and throat
  • signs of a severe skin reaction, e.g.:
    • a rash combined with fever or discomfort
    • a rash covering a large area of the body
    • a rash that spreads quickly
    • blistering
    • peeling

Some people may experience side effects other than those listed.  Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.

Allergy: Some people who are allergic to cephalosporin antibiotics also experience allergic reactions to penicillin. Before you take penicillin, inform your doctor about any previous adverse reactions you have had to medications, especially cephalosporins and other penicillins. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.

Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated, or pseudomembranous, colitis. Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking penicillin and contact your doctor as soon as possible.

Bacterial resistance: Misuse of an antibiotic such as penicillin may lead to the growth of resistant bacteria that will not be killed by the antibiotic. If this happens, the antibiotic may not work for you in the future. Although you may begin to feel better when you first start taking penicillin, you need to take all of the medication exactly as prescribed by your doctor to finish ridding your body of the infection and to prevent resistant bacteria from taking hold. Do not take penicillin or other antibiotics to treat a viral infection such as the common cold; antibiotics do not kill viruses, and using them to treat viral infections can lead to the growth of resistant bacteria.

Birth control: Whether penicillin decreases the effectiveness of birth control pills is controversial. Some doctors recommend adding another method of birth control for the rest of the menstrual cycle when penicillin is taken.

Kidney function: Penicillin is removed from the body by the kidneys. People with impaired kidney function are at risk of increased side effects and may need lower doses of penicillin. People with kidney disease or reduced kidney function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Overgrowth of organisms: Prolonged treatment with penicillin may allow normal fungus or types of bacteria not killed by the antibiotic to overgrow, causing unwanted infections such as yeast infections.

Pregnancy: Usual doses of penicillin appear to be safe during pregnancy.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking penicillin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

What other drugs could interact with this medication?

There may be an interaction between penicillin and any of the following:

  • BCG
  • birth control pills
  • chloramphenicol
  • cholera vaccine
  • erythromycin
  • fusidic acid
  • methotrexate
  • mycophenolate
  • teriflunomide
  • tetracycline antibiotics (e.g., doxycycline, minocycline, tetracycline)
  • tolvaptan
  • typhoid vaccine
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Pen-VK

V-Penicillin Slovakofarm – instructions for use, doses, side effects, reviews of the drug:

0.002 ‰

Analogs

All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics

Description of the drug Slovakopharm V-Penicillin (tablets, 250 mg) based on the official instructions, approved by the manufacturer in 2000

Approval date: 07/31/2000

Content

  • Active substance
  • ATX
  • Pharmacological group
  • Nosological classification (ICD-10)
  • Composition and form of release
  • pharmachologic effect
  • Indications
  • Contraindications
  • Use during pregnancy and lactation
  • Dosage and administration
  • Side effects
  • Interaction
  • Storage conditions
  • Best before date
  • Reviews

Active ingredient

Phenoxymethylpenicillin* (Phenoxymethylpenicillin*)

ATX

J01CE02 Phenoxymethylpenicillin

Pharmacological group

Penicillins

Nosological classification (ICD-10)

ICD-10 code list

Composition and formulation

1 tablet contains phenoxymethylpenicillin (in the form of potassium salt) 250 or 500 mg, 10 pcs in a blister . ; in a box of 3 blisters, or in glass bottles of 30 pieces, in a box 1 bottle.

Pharmacological action

Pharmacological action

antibacterial , germicidal .

Indications

Infections caused by susceptible microorganisms (cocci, tetanus and anthrax bacilli, actinomycetes, clostridia, etc.).

Contraindications

Hypersensitivity to beta-lactam antibiotics.

Use in pregnancy and lactation

Not teratogenic.

Dosage and administration

Inside without chewing. Adults – 500 mg (children aged 5-12 years – 250 mg) 4-6 times a day for at least 5-7 days.

Side effects

Allergic reactions (skin rash, urticaria, fever, eosinophilia, arthralgia, angioedema, anaphylactic shock). When prescribing large doses – bleeding, hyperkalemia. Very high doses of the drug cause CNS disorders, especially in children, elderly patients and on the background of renal failure.

Interactions

Sulfonamides and bacteriostatic antibiotics (tetracyclines, chloramphenicol, etc.) reduce, aminoglycosides increase efficiency. Excretion by the kidneys is slowed down by probenecid, phenylbutazone, salicylates, indomethacin. Reduces the effect of hormonal contraceptives.

Storage conditions

At a temperature of 15–25 °C.

Keep out of reach of children.

Expiry date

5 years.

Do not use after the expiry date which is stated on the packaging.

Update date: 04/23/2019

Reviews



Read all reviews and leave your own

Penicillin G Sodium salt instructions for use: indications, contraindications, side effects – description of Penicillin G sodium salt Powder for solution for injection (4179)

💊 Composition of the drug Penicillin G Sodium salt

✅ Use of the drug Penicillin G Sodium salt

Save

Search for analogues

⚠️ The state registration of this drug has been canceled

Description of the active ingredients of the preparation

Penicillin G Sodium Salt
(Penicillin G sodium salt)

The scientific information provided is general and cannot be used to make decisions.
decisions about the use of a particular drug.

Renewal date: 2020.03.18

Marketing authorization holder:

BIOCHEMIE GmbH
(Austria)

ATX code:

J01CE01

(Benzylpenicillin)

Active substance:
benzylpenicillin
(benzylpenicillin)

Rec.INN

WHO registered

Dosage form

Penicillin G Sodium Salt

Powder for preparation. solution for injections. 1 million units: fl. 100 pieces.

reg. No.: P N012660/01-2001
dated 07.02.01
– Cancellation of the state. registration

Release form, packaging and composition
drug Penicillin G Sodium salt

Vials (100) – cardboard boxes.

Clinical and pharmacological group:

Antibiotic of the penicillin group, destroyed by penicillinase

Pharmaco-therapeutic group:

Antibiotic, penicillin

Pharmacological action

Antibiotic of the biosynthetic penicillin group. It has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms.

Active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic spore-forming rods; as well as Actinomyces spp. , Spirochaetaceae.

Penicillinase-producing strains of Staphylococcus spp. are resistant to benzylpenicillin. Decomposes in an acidic environment.

Novocaine salt of benzylpenicillin compared to potassium and sodium salts is characterized by a longer duration of action.

Pharmacokinetics

After intramuscular administration, it is rapidly absorbed from the injection site. Widely distributed in tissues and body fluids. Benzylpenicillin penetrates well through the placental barrier, the BBB during inflammation of the meninges.

T 1/2 – 30 min. Excreted with urine.

Indications of the active substances of the drug

Penicillin G Sodium Salt

Treatment of diseases caused by microorganisms sensitive to benzylpenicillin: lobar and focal pneumonia, pleural empyema, sepsis, septicemia, pyemia, acute and subacute septic endocarditis, meningitis, acute and chronic osteomyelitis, urinary and biliary tract infections, tonsillitis, purulent skin infections, soft tissues and mucous membranes, erysipelas, diphtheria, scarlet fever, anthrax, actinomycosis, treatment of pyoinflammatory diseases in obstetric and gynecological practice, ENT diseases, eye diseases, gonorrhea, blennorrhea, syphilis.

Open list of ICD-10 codes

A22 Anthrax
A36 Diphtheria
A38 Scarlet fever
A40 Streptococcal sepsis
A41 Other sepsis
A42 Actinomycosis
A46 erysipelas
A50 Congenital syphilis
A51 Early syphilis
A52 Late syphilis
A54 Gonococcal infection
A54. 3 Gonococcal eye infection
G00 Bacterial meningitis, not elsewhere classified
h20 Conjunctivitis
h25.0 Sclerite
h25.1 Episcleritis
h26 Keratitis
h30 Iridocyclitis
H66 Suppurative and unspecified otitis media
I33 Acute and subacute endocarditis
J01 Acute sinusitis
J02 Acute pharyngitis
J03 Acute tonsillitis
J04 Acute laryngitis and tracheitis
J15 Bacterial pneumonia, not elsewhere classified
J20 Acute bronchitis
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
J32 Chronic sinusitis
J35. 0 Chronic tonsillitis
J37 Chronic laryngitis and laryngotracheitis
J42 Chronic bronchitis, unspecified
J86 Pyothorax (pleural empyema)
K81.0 Acute cholecystitis
K81.1 Chronic cholecystitis
K83.0 Cholangitis
L01 Impetigo
L02 Skin abscess, furuncle and carbuncle
L03 Phlegmon
L08. 0 Pyoderma
L08.8 Other specified local skin and subcutaneous tissue infections
M86 Osteomyelitis
N10 Acute tubulointerstitial nephritis (acute pyelonephritis)
N11 Chronic tubulointerstitial nephritis (chronic pyelonephritis)
N30 Cystitis
N34 Urethritis and urethral syndrome
N41 Inflammatory diseases of the prostate
N70 Salpingitis and oophoritis
N71 Inflammatory disease of the uterus other than the cervix (including endometritis, myometritis, metritis, pyometra, uterine abscess)
N72 Inflammatory disease of the cervix (including cervicitis, endocervicitis, exocervicitis)
N73. 5 Female pelvic peritonitis, unspecified
T79.3 Post-traumatic wound infection, not elsewhere classified

Dosage regimen

The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

Individual. Enter in / m, in / in, s / c, endolumbally.

When administered intramuscularly and intramuscularly to adults, the daily dose varies from 250,000 to 60 million units. The daily dose for children under the age of 1 year is 50,000-100,000 IU / kg, over 1 year – 50,000 IU / kg; if necessary, the daily dose can be increased to 200,000-300,000 IU / kg, according to vital indications – up to 500,000 IU / kg. Multiplicity of introduction 4-6 times / day.

Endolumbally administered depending on the disease and severity of the course, adults – 5000-10 000 IU, children – 2000-5000 IU. The drug is diluted in sterile water for injection or in 0.9% sodium chloride solution at the rate of 1 thousand units / ml. Before injection (depending on the level of intracranial pressure), 5-10 ml of CSF is removed and added to the antibiotic solution in equal proportions.

SC benzylpenicillin is used for chipping infiltrates (100,000-200,000 IU in 1 ml of 0.25%-0.5% novocaine solution).

Benzylpenicillin potassium salt is used only in / m and s / c, in the same doses as benzylpenicillin sodium salt.

Benzylpenicillin novocaine salt is used only in / m. The average therapeutic dose for adults: single – 300,000 IU, daily – 600,000 IU. Children under the age of 1 year – 50,000-100,000 U / kg / day, over 1 year – 50,000 U / kg / day. Multiplicity of introduction 3-4 times / day.

The duration of treatment with benzylpenicillin, depending on the form and severity of the course of the disease, can range from 7-10 days to 2 months or more.

Side effects

From the digestive system: diarrhea, nausea, vomiting.

Effects due to chemotherapeutic action: vaginal candidiasis, oral candidiasis.

From the side of the central nervous system: when using benzylpenicillin in high doses, especially with endolumbar administration, neurotoxic reactions may develop: nausea, vomiting, increased reflex excitability, symptoms of meningism, convulsions, coma.

Allergic reactions: fever, urticaria, skin rash, rash on mucous membranes, joint pain, eosinophilia, angioedema. Cases of anaphylactic shock with a fatal outcome are described.

Contraindications for use

Hypersensitivity to benzylpenicillin and other drugs from the group of penicillins and cephalosporins. Endolumbar administration is contraindicated in patients suffering from epilepsy.

Use in pregnancy and lactation

Use during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should decide on the termination of breastfeeding.

Use in impaired renal function

Use with caution in patients with impaired renal function.

Use in children

May be used in children if indicated.

Special instructions

Use with caution in patients with impaired renal function, with heart failure, predisposition to allergic reactions (especially with drug allergies), with hypersensitivity to cephalosporins (due to the possibility of cross-allergy).

If there is no effect after 3-5 days after the start of the application, it is necessary to switch to the use of other antibiotics or combination therapy.

In connection with the possibility of developing fungal superinfection, it is advisable to prescribe antifungal drugs during treatment with benzylpenicillin.

It must be taken into account that the use of benzylpenicillin in subtherapeutic doses or early termination of treatment often leads to the emergence of resistant strains of pathogens.

Leave a Reply

Your email address will not be published. Required fields are marked *