What is indapamide used for. How does indapamide work as a diuretic. What are the common and serious side effects of indapamide. How should indapamide be taken properly. What precautions should be followed when using indapamide. How can indapamide interact with other medications or conditions. Why is regular monitoring important when taking indapamide long-term.

Understanding Indapamide: A Powerful Diuretic Medication

Indapamide is a prescription medication classified as a thiazide-like diuretic, commonly referred to as a “water pill.” It is primarily used to treat high blood pressure (hypertension) and reduce swelling and fluid retention caused by various conditions, including heart disease. Indapamide works by increasing urine production, which helps the body eliminate excess water and salt.

How does indapamide work in the body?

Indapamide acts on the kidneys to increase urine output. Specifically, it inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubules of the nephron. This leads to increased excretion of water, sodium, and chloride. By reducing fluid volume in the body, indapamide helps lower blood pressure and alleviate edema (swelling) associated with various medical conditions.

Common Side Effects of Indapamide: What to Expect

While indapamide is generally well-tolerated, it can cause several common side effects that occur in more than 1 in 100 people. Being aware of these potential effects can help patients better manage their treatment:

• Mild skin rash
• Nausea or vomiting
• Dizziness or lightheadedness
• Headache
• Fatigue
• Muscle cramps
• Increased urination

Is there anything patients can do to manage these side effects? Yes, there are several strategies that may help:

1. For mild skin rash: Consult with a doctor, as treatment adjustments may be necessary.
2. For nausea or vomiting: Take indapamide after a meal and stick to simple, bland foods. Stay hydrated by sipping water or clear fluids.
3. For dizziness: Sit or lie down until the feeling passes. Avoid sudden changes in position.
4. For increased urination: Plan activities around bathroom access and consider taking the medication earlier in the day to minimize nighttime disturbances.

Serious Side Effects: When to Seek Medical Attention

While rare, indapamide can cause serious side effects that require immediate medical attention. Patients should be vigilant and contact their healthcare provider or seek emergency care if they experience any of the following:

• Irregular heartbeat (arrhythmia)
• Severe stomach pain accompanied by nausea, vomiting, and fever (possible signs of pancreatitis)
• Symptoms of liver disease: yellowing of the eyes or skin, dark urine, pale stools, fatigue, and loss of appetite
• Signs of a serious allergic reaction (anaphylaxis)

When should patients call emergency services for a potential allergic reaction to indapamide? Immediate medical attention is crucial if any of these symptoms occur:

• Sudden swelling of the lips, mouth, throat, or tongue
• Difficulty breathing or wheezing
• Tightness in the throat or trouble swallowing
• Blue, grey, or pale discoloration of the skin, tongue, or lips
• Sudden confusion, drowsiness, or dizziness
• Fainting or unresponsiveness
• In children: limpness, floppiness, or unusual unresponsiveness

Long-Term Use of Indapamide: Monitoring and Precautions

For patients taking indapamide over an extended period, regular medical supervision is essential. Why is ongoing monitoring important for long-term indapamide users?

Regular check-ups allow healthcare providers to:

• Monitor blood pressure to ensure the medication is effective
• Conduct blood and urine tests to check electrolyte balance (calcium, sodium, and potassium levels)
• Assess kidney function
• Adjust dosage if necessary
• Identify any potential long-term side effects

The frequency of these check-ups may vary depending on individual factors such as the reason for taking indapamide, recent dosage changes, presence of side effects, and other health conditions or medications.

Proper Usage and Dosage Guidelines for Indapamide

To maximize the benefits of indapamide while minimizing potential side effects, it’s crucial to follow proper usage guidelines:

• Take indapamide exactly as prescribed by your healthcare provider
• Typically, the medication is taken once daily in the morning
• It can be taken with or without food, but taking it after a meal may help reduce nausea
• Avoid taking indapamide too close to bedtime, as increased urination may disrupt sleep
• Do not stop taking indapamide suddenly without consulting your doctor

How should patients handle a missed dose of indapamide? If a dose is missed, take it as soon as remembered. However, if it’s almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Never double up on doses to make up for a missed one.

Indapamide Interactions: Medications and Conditions to Consider

Indapamide can interact with various medications and medical conditions, potentially affecting its efficacy or increasing the risk of side effects. Patients should inform their healthcare provider about all medications, supplements, and health conditions before starting indapamide treatment.

Medications that may interact with indapamide include:

• Other blood pressure medications
• Certain antidepressants
• Lithium
• NSAIDs (e.g., ibuprofen, naproxen)
• Digoxin
• Corticosteroids

Medical conditions that require special consideration:

• Kidney disease
• Liver disease
• Gout
• Diabetes
• Lupus
• Allergies to sulfa drugs

Why is it crucial to disclose all medications and health conditions to healthcare providers? This information allows for proper assessment of potential risks and benefits, enabling healthcare providers to make informed decisions about the suitability of indapamide for each individual patient.

Lifestyle Considerations When Taking Indapamide

While indapamide is an effective medication for managing blood pressure and fluid retention, certain lifestyle factors can impact its effectiveness and overall health outcomes:

Dietary considerations:

• Follow a low-sodium diet as recommended by your healthcare provider
• Maintain adequate potassium intake through diet or supplements (under medical supervision)
• Stay well-hydrated, but avoid excessive fluid intake
• Limit alcohol consumption, as it can increase the risk of dehydration and dizziness

Physical activity:

• Engage in regular physical activity as approved by your healthcare provider
• Be cautious when starting new exercise routines, as indapamide may cause dizziness
• Stay hydrated during physical activities

Sun protection:

• Indapamide may increase skin sensitivity to sunlight
• Use sunscreen and protective clothing when outdoors
• Avoid prolonged sun exposure, especially during peak hours

How can patients effectively incorporate these lifestyle considerations while taking indapamide? It’s essential to work closely with healthcare providers to develop a personalized plan that addresses individual needs and health goals. Regular communication about any challenges or concerns can help optimize treatment outcomes and overall well-being.

Special Populations and Indapamide Use

Certain groups of people may require special considerations when using indapamide:

Elderly patients:

• May be more sensitive to the effects of indapamide
• Dosage adjustments may be necessary
• Increased risk of electrolyte imbalances and dehydration
• Regular monitoring is crucial

Pregnant women:

• Indapamide is generally not recommended during pregnancy
• Potential risks to the fetus should be discussed with a healthcare provider
• Alternative treatments may be considered

Breastfeeding mothers:

• Indapamide may pass into breast milk
• Potential effects on the nursing infant should be evaluated
• Alternative treatments may be recommended

Patients with diabetes:

• Indapamide may affect blood sugar levels
• More frequent blood glucose monitoring may be necessary
• Dosage adjustments of diabetes medications might be required

Why is individualized care important for these special populations? Each group faces unique challenges and risks when using indapamide. Tailored approaches ensure that the benefits of treatment outweigh potential risks, maximizing safety and efficacy for each patient.

Side effects of indapamide – NHS

Common side effects

These common side effects of indapamide happen in more than 1 in 100 people. There are things you can do to help cope with them:

Mild skin rash

If you get a mild rash, speak to your doctor for advice as your treatment may need to be changed.

Feeling or being sick (nausea or vomiting)

Try taking indapamide after a meal. Try to stick to simple foods and avoid rich or spicy meals. Drink water or squash in small, frequent sips so you do not get dehydrated.

Speak to your doctor if you feel sick or are being sick frequently, or are unable to drink properly for more than a week.

If you take contraceptive pills and you’re being sick (vomit) your contraception may not protect you from pregnancy. Look on the pill packet to find out what to do.

Feeling dizzy or faint

Try sitting or lying down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Do not drive, ride a bike or use tools or machinery while you’re feeling dizzy.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or does not go away.

Serious side effects

Serious side effects are usually rare and happen in less than 1 in 1,000 people.

Tell your doctor or call 111 straight away if you:

• get an irregular heartbeat (arrhythmia)
• get a severe stomach pain that develops suddenly, along with feeling or being sick, diarrhoea, indigestion, a high temperature, and tenderness or swelling of your stomach – these could be signs of pancreatitis
• feel or start being sick, get yellow eyes or skin, although this may be less obvious on brown or black skin, have dark pee, pale poo, tiredness and loss of appetite – these could be signs of liver disease

Serious allergic reaction

In rare cases, indapamide may cause a serious allergic reaction (anaphylaxis).

Immediate action required: Call 999 now if:

• your lips, mouth, throat or tongue suddenly become swollen
• you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
• your throat feels tight or you’re struggling to swallow
• your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• you suddenly become very confused, drowsy or dizzy
• someone faints and cannot be woken up
• a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Long-term side effects

If you are taking indapamide for a long time, you will occasionally have to see your doctor or nurse to get your blood pressure checked and have blood and urine tests. This is to make sure the salts (calcium, sodium and potassium) in your blood are balanced properly and your kidneys are working well.

How often you’ll need these tests will depend on the reason you’re taking indapamide, whether your dose has changed recently, whether you get side effects from indapamide, or if you have any other health problems or are taking other medicines.

Other side effects

These are not all the side effects of indapamide. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 4 March 2022

Next review due: 4 March 2025

Indapamide: MedlinePlus Drug Information

pronounced as (in dap’ a mide)

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Indapamide, a ‘water pill,’ is used to reduce the swelling and fluid retention caused by heart disease. It also is used to treat high blood pressure. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.

This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Indapamide comes as a tablet to take by mouth. It usually is taken once a day, in the morning. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take indapamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Indapamide controls high blood pressure but does not cure it. Continue to take indapamide even if you feel well. Do not stop taking indapamide without talking to your doctor.

Indapamide also is used to treat swelling and fluid retention caused by various medical conditions other than heart disease. Talk to your doctor about the possible risks of using this medicine for your condition.

Before taking indapamide,

• tell your doctor and pharmacist if you are allergic to indapamide, sulfa drugs, or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medications for high blood pressure, corticosteroids (e.g., prednisone), digoxin (Lanoxin), indomethacin (Indocin), lithium (Eskalith, Lithobid), probenecid (Benemid), and vitamins.
• tell your doctor if you have or have ever had heart rhythm problems, diabetes, gout, or kidney, liver, thyroid, or parathyroid disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Do not breast-feed while taking this medicine. If you become pregnant while taking indapamide, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking indapamide.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
• remember that alcohol can add to the drowsiness caused by this drug.

Follow your doctor’s directions. They may include a daily exercise program and a low-sodium or low-salt diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Frequent urination may last for up to 6 hours after a dose and should decrease after you take indapamide for a few weeks. Tell your doctor if any of these symptoms are severe or do not go away:

• muscle cramps
• drowsiness
• dizziness
• confusion
• thirst
• upset stomach
• vomiting
• stomach cramps
• decreased sexual ability
• blurred vision

If you have any of the following symptoms, call your doctor immediately:

• rapid, excessive weight loss
• severe skin rash with itching
• difficulty breathing or swallowing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

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^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 10/15/2017

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What helps, side effects, contraindications

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. number 31917

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Contents of the article

• Indapamide: dosage
• Indapamide: mechanism of action
• Indapamide: before meals or after meals
• Indapamide: how long can you take it without interruption
• Indapamide: contraindications
• Indapamide: side effects for women
• Indap or Indapamide: which is better
• Summary
• Ask an expert on the topic of the article

Diuretics are medicines with a diuretic effect. Diuretic drugs began to be used for long-term treatment of arterial hypertension in the late 1950s. Medicines from the group of thiazide diuretics are prescribed for the treatment of hypertension in patients with osteoporosis. Often osteoporosis occurs in women during menopause. In this case, drugs of the thiazide group are the drugs of choice in the treatment of arterial hypertension in combination with osteoporosis.

Let’s talk about one of the drugs, its use – Indapamide.

Indapamide: dosage

Preparation with the same active ingredient.

Indapamide is available in two strengths – Indapamide 2.5 mg and Indapamide retard 1.5 mg. The prefix retard means that the drug is of moderate strength and long duration.

All products Indapamide

12 reviews

Indapamide: mechanism of action

The drug belongs to sulfonamide derivatives, inhibits the absorption of sodium ions in the kidneys. This increases the release of sodium, potassium, magnesium and chlorine ions, which leads to an increase in the volume of urine formed over a certain period of time. Does indapamide help with pressure? Yes, the drug has a hypotensive effect by improving the elastic properties of the arteries and reducing vascular resistance.

Indapamide before meals or after meals

Indapamide tablets can be taken with or without food, preferably in the morning.

Indapamide: how long can I take it without interruption

Can I take Indapamide continuously? To treat hypertension, doctors prescribe Indapamide to be taken on a regular basis. If within 4-8 weeks there is no desired therapeutic effect, it is necessary to tell the doctor about it.

Indapamide: contraindications

The drug has the following contraindications:

• individual intolerance to the drug components
• renal insufficiency
• liver disorders
• hypokalemia
• galactose and lactase intolerance, glucose-galactose malabsorption
• pregnancy and lactation
• children under 18 years of age

Indapamide: side effects for women

Patients most often report such adverse reactions as:

• allergic rash
• abdominal and chest pain
• edema
• constipation, nausea, diarrhea
• cough, pharyngitis, sinusitis

Seek medical attention if adverse reactions occur.

Indap or Indapamide: which is better

The drugs have identical active ingredients. Accordingly, the pharmacological action, contraindications and side effects are similar.

Indapamide and Indap are available in tablets and capsules.

Indap is produced in the Czech Republic, Indapamide is produced by many Russian manufacturers.

It is impossible to draw a conclusion about which drug is better. The drug can be selected from your own preferences and pricing policy.

All products Indap

10 reviews

Summary

• Indapamide is produced in two dosages – Indapamide 2.5 mg and Indapamide retard 1.5 mg.
• The drug belongs to sulfonamide derivatives, inhibits the absorption of sodium ions in the kidneys.
• Indapamide tablets can be taken with or without food, preferably in the morning.
• To treat hypertension, doctors prescribe Indapamide to be taken on a regular basis.
• The drug has contraindications.
• Seek medical attention if adverse reactions occur.
• Indap is produced in the Czech Republic, Indapamide is produced by many Russian manufacturers.

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Indapamide: instruction, price, analogues | Hemofarm 9 film-coated tablets0001

• Pharmacological properties
• Indications Indapamide
• Application of Indapamide
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Storage conditions
• Diagnosis
• Recommended alternatives
• Trade names

indapamide ((RS)-4-chloro-3-sulfamol-N-(2-methyl-2,3 dihydro-1H-indol-1-yl)benzamide) is a diuretic, antihypertensive agent of the group of nonthiazide sulfonamides. Indapamide causes a decrease in the tone of the smooth muscles of the arteries due to a change in the transmembrane current of calcium ions, a decrease in the sensitivity of the vascular wall to noradrenaline and angiotensin, which leads to a decrease in OPSS. Indapamide stimulates the synthesis of prostaglandin E ₂ , which has a vasodilating and hypotensive effect. It exhibits a moderately pronounced diuretic effect, which is associated with blocking the reabsorption of sodium, chlorine, water and, to a lesser extent, potassium and magnesium ions. Indapamide does not disrupt lipid metabolism and does not adversely affect carbohydrate metabolism, does not affect the level of total cholesterol and TG, and reduces the level of phosphates in the blood serum. The therapeutic effect develops after 7-8 days, the maximum effect – after 4 weeks.

After oral administration, indapamide is rapidly absorbed, the maximum serum concentration is reached after 2-2.5 hours and is 230-260 ng / ml. Approximately 71-79% of indapamide binds to plasma proteins, mainly to α ₁ -glycoprotein. Widely distributed in body tissues. The half-life is 14 hours. It is metabolized in the liver. It is excreted in the urine (7% – unchanged for 48 hours, 70% – in the form of metabolites) and bile (about 23%).

Mild to moderate hypertension.

adults – 2.5 mg 1 time per day, preferably in the morning. In case of insufficient hypotensive effect, the dose is increased to 5 mg per day (in one dose in the morning). Increasing the dose of the drug enhances the diuretic effect.

hypersensitivity to indapamide and other components of the drug, as well as to sulfonamides, acute cerebrovascular accidents, hyperaldosteronism, severe liver and kidney dysfunction, hypokalemia.

headache, fatigue, convulsions, diarrhea, skin rash, frequent urination, in isolated cases orthostatic hypotension.

with are prescribed with special care to patients with impaired liver and kidney function. During treatment with the drug, periodic monitoring of the level of electrolytes in the blood serum is necessary due to the possibility of developing hypokalemia and disturbed water and electrolyte balance. Patients with hyperuricemia and gout who use indapamide need periodic monitoring of the level of uric acid in the blood serum.

During treatment with the drug, clinical manifestations of latent diabetes mellitus, as well as a change in the need for insulin, are possible. By lowering blood pressure, the drug may affect the ability to drive vehicles and mechanisms. Indapamide should not be prescribed during pregnancy and lactation.

it is possible to potentiate the action of other antihypertensive agents when used simultaneously with Indapamide. Do not prescribe simultaneously with lithium preparations, as this increases the risk of developing the toxic effects of the latter (due to a decrease in the renal clearance of lithium and an increase in its concentration in the blood plasma).