Vitamin C Injection Benefits & Treatment

Here’s some info about vitamin C injection benefits.

As one of the most powerful antioxidants on the planet, Vitamin C helps to destroy cancer cells and boost immune function – at the same time.

Vitamin C is a water-soluble vitamin that is vital for many of your body’s systems to function properly. Vitamin C is also an antioxidant that provides many health and anti-aging benefits.

It is so powerful that it protects other antioxidants from incurring free radical damage. It is required for tissue growth, repair, adrenal gland function, and even aides in the production of anti-stress hormones.

Vitamin C Cannot be Manufactured by the Body

Vitamin C cannot be manufactured by the body, so it’s essential that it is obtained through your diet, a form of supplement or in the magical effectiveness of Vitamin C injected straight into the bloodstream.

It’s important to replenish Vitamin C to prevent negative symptoms of vitamin deficiency. Some symptoms of Vitamin C deficiency are cardiovascular disease, fatigue, frequent infections and unhealthy weight loss, just to name a few.

Vitamin C injection Benefits

Vitamin C injection is a focus that adds the greatest long-term health benefits in disease or preventative treatment. It establishes a concentration of an essential nutrient into the body.

Human studies of Vitamin C injections reveal improved quality of life in patients, including reduced nausea, vomiting, pain and appetite loss, in addition to increased physical, mental and emotional functions. Vitamin C even plays a role in brain health, as it is necessary to make certain neurotransmitters, including serotonin.

It has also been found to play a role in preventing the common cold, cancer, osteoarthritis, age-related macular degeneration, asthma, and more.

More About Vitamin C

Dr. Linus Pauling is a two-time Nobel Prize winner that expressed through his research the efficacy of Vitamin C and its enormous benefits to the longevity of the human body. He stressed that in the proper intake of certain nutrients, such as Vitamin C, life can be extended through the increase of well-being by twenty-five or even thirty-five years.

Call Tampa Rejuvenation today to learn more about how to incorporate Vitamin C into your diet.

Individual results vary by patient. Ask your Tampa Rejuvenation practitioner about your specific health concerns.

Uses, Dosage, Side Effects, Interactions, Warning

DOSAGE AND ADMINISTRATION

Ascorbic acid (vitamin c) is usually administered orally. When oral administration is not feasible or when malabsorption is suspected, the drug may be administered IM, IV, or subcutaneously. When given parenterally, utilization of the vitamin reportedly is best after IM administration and that is the preferred parenteral route.

For intravenous injection, dilution into a large volume parenteral such as Normal Saline, Water for Injection, or Glucose is recommended to minimize the adverse reactions associated with intravenous injection.

The average protective dose of vitamin C for adults is 70 to 150 mg daily. In the presence of scurvy, doses of 300 mg to 1 g daily are recommended. However, as much as 6 g has been administered parenterally to normal adults without evidence of toxicity.

To enhance wound healing, doses of 300 to 500 mg daily for a week or ten days both preoperatively and postoperatively are generally considered adequate, although considerably larger amounts have been recommended. In the treatment of burns, doses are governed by the extent of tissue injury. For severe burns, daily doses of 1 to 2 g are recommended. In other conditions in which the need for vitamin C is increased, three to five times the daily optimum allowances appear to be adequate.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.

HOW SUPPLIED

Ascorbic Acid (vitamin c) Injection, USP, 250 mg/mL is available in 2 mL ampules, in cartons of 25.

PROTECT FROM HEAT AND LIGHT. Store at controlled room temperature 15°-
30° C (59°- 86° F).

Pressure may develop within the ampule upon long storage. Precautions should be taken to wrap the container in a protective covering while it is being opened.

CAUTION: Federal law prohibits dispensing without prescription.

Manufactured by: Steris Laboratories, Inc. Phoenix, Arizona
85043, USA. For: Mallinckrodt, Inc. St. Louis, MO 63134. FDA Rev date: n/a

Ascorbic Acid (Vitamin C) Injection Information

1. Drugs A to Z
2. Ascorbic Acid (Vitamin C) Injection
3. Consumer Drug Information

Generic Name: Ascorbic Acid (Vitamin C) Injection (ASS kor bik ASS id)
Brand Name: Ascor L 500, Betac

Medically reviewed by Drugs.com. Last updated on Sep 4, 2020.

Uses of Ascorbic Acid Injection:

• It is used to treat or prevent vitamin C deficiency.
• It is used to treat scurvy.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Ascorbic Acid Injection?

• If you have an allergy to ascorbic acid or any other part of ascorbic acid (vitamin C) injection.
• If you are allergic to ascorbic acid (vitamin C) injection; any part of ascorbic acid (vitamin C) injection; or any other drugs, foods, or substances. Tell your doctor about the allergy and
  what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check
to make sure that it is safe for you to take ascorbic acid (vitamin C) injection with all of your drugs and health problems. Do not start, stop, or change the dose of
any drug without checking with your doctor.

What are some things I need to know or do while I take Ascorbic Acid Injection?

• Tell all of your health care providers that you take ascorbic acid (vitamin C) injection. This includes your doctors, nurses, pharmacists, and dentists.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take ascorbic acid (vitamin C) injection.
• If you have high blood sugar (diabetes), talk with your doctor.
• If you are on a low-salt or salt-free diet, talk with your doctor.
• Kidney stones or other very bad kidney problems have rarely happened in people taking high doses of ascorbic acid (vitamin C) injection for a long time. The risk may
  be higher in people who have had kidney problems or kidney stones. The risk may also be higher in people 65 or older and children younger than
  2 years of age.
• Do not take ascorbic acid (vitamin C) injection for longer than you were told by your doctor.
• Be careful if you have G6PD deficiency. Anemia may happen.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using ascorbic acid (vitamin C) injection
  while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Ascorbic Acid Injection) best taken?

Use ascorbic acid (vitamin C) injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into a muscle, vein, or into the fatty part of the skin.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your
doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing;
  tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue,
  or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Feeling very tired or weak.
• Dark urine or yellow skin or eyes.
• Back pain, belly pain, or blood in the urine. May be signs of a kidney stone.

What are some other side effects of Ascorbic Acid Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical
help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical
advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was
taken, how much, and when it happened.

How do I store and/or throw out Ascorbic Acid Injection?

• If you need to store ascorbic acid (vitamin C) injection at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your
  pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about ascorbic acid (vitamin C) injection, please talk
  with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was
  taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Intravenous Vitamin C – Paradigm Naturopathic Medicine

It is becoming apparent that the classic high dose-model of administering vitamin C-based treatments is not typically needed and may in fact be detrimental or harmful. Higher-dose treatments (i.e. beyond 50-75 grams/infusion) can place the body in an increased state of stress and actually further exhaust the body over time – more is not necessarily better. This is one of the reasons why we do not typically go beyond 25 grams of vitamin C-based infusions with patients and yet the benefits remain (and the results are in fact better). Other experienced physicians who have been using vitamin C-based treatments in people with cancer well over a decade are also noticing a similar trend. Experience is crucial in this area.

While the more standard oncology community feels that such treatments should not be combined with either chemotherapy or radiation, a growing body of data is showing that this recommendation is incorrect or wrong. Clinical experience clearly demonstrates that a combination approach allows for a “synergistic-effect” to, for example, enhance chemotherapy while at the same time protecting the body (i.e. decrease negative side-effects). Case after case is demonstrating how the effectiveness of chemo can go along long way when taken together with intravenous vitamin C treatment. Radiation is showing a similar trend however the data is more preliminary.

Dr. Spooner believes that the greatest benefit of vitamin C lies in its combination with conventional treatment versus using each one on its own.

Cancer cells respond very differently to intravenous vitamin C than when compared to the body’s normal cells. For example, a cancer cell makes a rather rapid and sustained increase in hydrogen peroxide in response to vitamin C which results in a “rusting-effect” known as oxidative damage (i. e. this is how many chemo agents work to kill cancer). Normal or healthy cells do not respond this way with vitamin C. This phenomenon makes intravenous vitamin C a very unique and targeted treatment unlike any other chemotherapy-like medicine.

It is important that each intravenous treatment be tailored to the individual patient and particular situation. Protocols are adjusted based on how the patient is feeling, the type of cancer(s), conventional treatments they are receiving, and what is financially feasible over time. Supportive ingredients alongside the vitamin C assist in enhancing the effectiveness of the treatment.

Typically, a person would receive 2-3 treatments per week and the duration depends on how a patient responds. In the beginning, it is advised that a person try a treatment cycle for at least 8 weeks to help assess the potential benefit of treatment. Doses are started low and gradually increased to better customize a person’s individual tolerance.

Similar to a treating medical oncologist, there may be a need to adjust or change a treatment protocol at any time. We have many, many protocols to use in cancer care, and the art of medicine is to determine which one works best for you.

 

Basic Facts Why Intravenous vs. Oral Vitamin C is Key in the treatment of Cancer:

Vitamin C levels in the body are tightly controlled by the bowels and the kidney’s (i.e. the body gets rid of it quickly)
Even by taking up to 18000mg per day orally in divided doses throughout the day, the blood levels do not change and do not exceed 0.2 mMol/L
Intravenous vitamin C bypasses the tight control by the body leading to a 70-fold higher blood levels with only a 2000mg injection
A simple injection of 5000mg of vitamin C produces a blood value of 3mMol/L and the research has shown that you can kill most cancer cells in the laboratory with values between 0.5 to 3mMol/L

How Intravenous Vitamin C (IVC) may work in killing cancer (chemotherapeutic action):

Increased production of hydrogen peroxide production (pro-oxidant)
Anti-angiogenesis (stop the blood supply that feeds cancer)
Immune system support (interferon, interleukin, etc. )
Anti-inflammatory
Stromal Support
And many, many, many other ways

Safety of Intravenous Vitamin C:

A 2010 study evaluating the use of vitamin C amongst practitioners revealed, after calculating over 750,000 yearly sales and estimated yearly doses of over 350,000 in 2008, and after evaluating over 9000 patients, only minor side-effects were noted that included lethargy/fatigue, change in mental status, and vein irriation. Clinically, if these effects occur they are temporary and easily corrected.

Padayatty SJ et a. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414.

Precautions:

The negative side effects of vitamin C IV are rare. However, there are concerns and potential side effects to be considered:

Although it has been reported only once in the literature (Scot Med J 1979;24:151), tumor necrosis, hemorrhage, and subsequent death after a single intravenous 10 gram dose of vitamin C should be the highest priority for safety. This is why we always begin with a small dose.
Another report described acute oxalate nephropathy in a patient with bilateral ureteric obstruction and renal insufficiency who received 60 gram IVC. Consequently, we need to ensure that your kidneys are working well enough before beginning and especially with a higher-dose infusion.
A rare hemolysis can occur in patients with a red cell glucose-6-phosphate dehydrogenase deficiency (G6PD) and so this may be screened in select cases.
Localized pain at the infusion site can occur if the infusion rate is too high or the pH too low. This is easily corrected by either slowing the rate or adjusting the formula.
Vitamin C may decrease the levels of calcium, chloride, and potassium and as a consequence some patients may experience shakiness or ache. This is treated by further adjusting the formula with those ingredients.
Given the amount of fluid and sodium that is used as the carrier for vitamin C, any condition which could be affected by the increased fluid load (i. e. congestive heart failure, ascites, edema, pleural effusion, etc.) needs to be monitored more closely and a tailored protocol given accordingly.
IVC may be dehydrating and cause a temporary lowering of blood sugar, and so proper hydration and nourishment needs to be emphasized prior to each treatment and following
As with any intravenous injection, infiltration or vein irritation is always possible

Overall “Positive” Effects of Intravenous Vitamin C:

Correction of any possible vitamin C deficiency (i.e. fatigue, bleeding)
Immune-modulation (enhance or calm down)
Cytotoxic to cancer (chemotherapeutic potential)
Support white blood cells (they have 10-30x higher levels than the blood)
Stimulation of collagen formation (wall off tumors)
Inhibition of hyaluronidase (prevent cancer spread)
Enhanced wound healing after surgeries, biopsies
Enhanced benefits of chemotherapy and radiation
Support the bone marrow and especially the platelets
Anti-inflammatory
Anti-stress and Anti-depressant properties

 

Is IV vitamin C effective against COVID-19? | Linus Pauling Institute

Vitamin C, also known as ascorbic acid, is currently making headlines in the fight against COVID-19. Reports say that intravenous (IV) vitamin C may help people suffering from this disease.

Recently, IV vitamin C clinical trials began in China and Italy. Doctors in hard-hit areas of the United States are now reporting using it. Furthermore, IV vitamin C appears in some COVID-19 critical care guidelines, like at the Eastern Virginia Medical School.

Even though using IV vitamin C is nothing new, there is not enough scientific evidence to determine if it works against COVID-19.  Read on for more information.

What is IV vitamin C?

A solution of vitamin C is delivered directly into the bloodstream through a vein, typically in the arm. A physician’s order is required to receive this treatment. It is important to get IV vitamin C only in a clinic or other medical setting.

 

Why use IV vitamin C?

IV vitamin C goes straight into the bloodstream. Because it skips the stomach and intestines, vitamin C in the blood rises to very high levels and very quickly.

What do we know about IV vitamin C in COVID-19?

The clinical data from IV vitamin C trials will not be available for many months. So far, doctors and researchers cannot tell how effective IV vitamin C is or how it might work.

There is some scientific evidence that IV vitamin C can be useful in the treatment of other infections. Most of the recorded use of IV vitamin C has been in the treatment of cancer.

To be clear: IV vitamin C is not a cure for COVID-19. 

What about vitamin C supplements?

It is hard to compare them. You cannot get blood vitamin C levels nearly as high as IV vitamin C when taking vitamin C supplements. 

Despite label claims, no supplement is equal to IV vitamin C – no matter how much you take or what formula you use.

Can vitamin C supplements help your immune system? Yes, but for different reasons.

Caution: Be careful taking very high doses of vitamin C supplements. They can also cause unwanted side effects such as abdominal cramping and diarrhea.

How might IV vitamin C work in COVID-19 patients?

There are several theories about how IV vitamin C may help treat COVID-19:

• Very high vitamin C levels may create free radicals that destroy viruses and bacteria. Our body’s cells have defenses against these free radicals, but viruses do not.
• Another possibility is IV vitamin C renews the body’s antioxidant protection. Serious infections can use up our body’s vitamin C and other antioxidants very quickly.

Vitamin C is a vital part of the immune system, but there is no reason to think IV vitamin C can boost your immune system beyond normal, healthy status. Daily vitamin C from food or supplements is enough to support healthy immunity.

Is IV vitamin C safe?

IV infusions always require proper administration by a medical professional. Patients need to be screened to make sure it is safe for them. Some conditions might prevent a person from getting IV vitamin C.

From research on vitamin C and cancer, we know that IV vitamin C is safe when medical guidelines are followed.

Conclusions

• Although doctors are using IV vitamin C, there is no published scientific evidence about the use of IV vitamin C in COVID-19. Therefore, we cannot fully evaluate its effectiveness.

• IV vitamin C is not the same as taking vitamin C supplements. Vitamin C supplements may help the immune system, but vitamin C blood levels that are far lower than IV vitamin C.

• The National Cancer Institute provides more information about IV vitamin C that may be helpful if you want to know more about this therapy.

• For more information about vitamin C in the immune system, see the Micronutrient Information Center. 

Authors: Alexander Michels, PhD; Victoria Drake, PhD; Sandra Uesugi, RN, BSN, MS, all from the Linus Pauling Institute at Oregon State University. Contact information here.

High Dose Vitamin C IV

Vitamin C has such broad applications because it is a key factor in collagen production (skin, blood vessels, ligaments and bones), adrenalin and carnitine synthesis (energy), it directly boosts the immune system, and it has a potent antioxidant function. So let’s look at each of these in turn.

Collagen Production

Collagen is the structural protein found in all animal tissue. It holds our muscles to our bones, provides structural support for veins and arteries, and more.

Vitamin C is required for collagen synthesis along with the amino acids proline and lysine (1). When you don’t have enough collagen, you may have thin skin and weaker blood vessels, bones, tendons and ligaments. This can lead to aneurysms (blood vessel wall thinning), possible stroke, and even the ruptured ligaments and tendons commonly seen in sports injuries.

High doses of vitamin C when administered by IV can bolster skin and connective tissue and prevent these outcomes.

Energy Production

Vitamin C is required in the breakdown of fat for energy use. It takes part in the synthesis of a molecule called carnitine which serves as a shuttle bringing fats into the mitochondria in our cells for energy production.

This means it can have a powerful influence on our energy levels. For example, a 2011 scientific study showed high dose (10 grams) vitamin C given by IV reduced fatigue in office workers after 2 hours and continued its effect for 24 hours (2)

Immune Support

Vitamin C may have a direct effect against infectious agents like bacteria, viruses, and even cancer cells. (The use of Vitamin C in cancer is still controversial but is being studied and is promising… read more below.) At very high doses it can generate peroxide (h3O2) which may account for this effect.

Before the polio vaccine, vitamin C was used as a high dose intramuscular injection every 8 hours in the treatment of polio with some success. More recently in mice genetically modified to lose the ability to make vitamin C, external vitamin C was shown to increase the mice’s ability to increase anti-influenza cytokines (powerful immune system cells) and fight influenza virus infections (3).

Antioxidant Properties

Vitamin C is a potent antioxidant that helps protect cell structures like collagen, proteins, and DNA from damage by free radicals and reactive oxygen species (ROS) which are common in high stress states, chronic illness and infections.

Research has shown that the antioxidant properties of vitamin C can reduce the severity of symptoms associated with h2N1 influenza virus and is considered an important add-on therapy in surviving the flu (4).

Cancer and Chemotherapy

The role of vitamin C as a therapy for cancer is very controversial. No large scale studies have been done to definitively conclude one way or another if vitamin C has a role in the treatment of cancer. Here is what we do know:

1. Vitamin C even in high doses of 1.5 grams/ kg (over 100 grams) is safe and tolerated very well with very few side effects. Even the myth of kidney stones (oxalic acid) has been dispelled in recent studies which have shown that oxalic acid levels remain well controlled even with high doses of vitamin C. (5)
2. IV vitamin C becomes an oxidant at high doses as opposed to its antioxidant function at lower doses. This is because vitamin C interacts with oxygen and iron to cause the formation of high concentrations of peroxide (h3O2) in tissues. Peroxide is used by immune cells to kill foreign invaders and cancer cells. Vitamin C also depletes ATP and causes DNA damage to cancer cells. (7)
3. High dose IV vitamin C can be used safely in conjunction with chemotherapy (except methotrexate) and radiation in certain situations in which the patient’s oncological team is aware of and has agreed to incorporate vitamin C as a treatment modality. (5, 6)
4. High dose IV vitamin C may improve mood and energy for patients undergoing cancer treatment using other modalities. (5)
5. High dose IV vitamin C can be used safely in treatment of terminal cancers which have not responded to chemotherapy and radiation treatment even if it may be of limited use in further killing these cancer cells. (5)

Some of the most active treatment and research for the use of high dose IV vitamin C is coming out of The Riordan Clinic in Wichita, Kansas where they have been using it for decades. The clinic has published a well-known protocol that has become a standard for scientific studies on high dose IV vitamin C. This protocol is what we follow in our clinic, and can be accessed here.

In addition, the University of Kansas Medical Center is also actively researching the use of high dose IV vitamin C in cancer, and has a full time clinic with 10 chairs and 2 isolation rooms dedicated solely to the treatment of cancer patients with this therapy. You can read more about it here and here.

Lastly, the US Government NIH National Cancer Institute publishes updated information on the current state of research and knowledge on the use of high dose IV vitamin C in the treatment of cancer. This can be accessed here.

Vitamin C (ascorbate) is a powerful antioxidant and several critical enzymes require vitamin C in the synthesis of collagen from proline and lysine. Vitamin C is, therefore, required for the maintenance of normal connective tissue as well as for wound healing since synthesis of connective tissue is the first event in wound tissue remodeling. Vitamin C is also necessary for bone remodeling due to the presence of collagen in the organic matrix of bones.

Vitamin C is required for conversion of tyrosine to epinephrine (adrenalin), and the synthesis of the bile. It is present in high amounts in the adrenal gland cortex and these levels are depleted after adrenocorticotropic hormone (ACTH) stimulation of the gland and synthesis of the stress hormone cortisol, which is why it’s important to replete vitamin C level during times of high stress.

References

1. Mussini E, Hutton JJ, Udenfriend S. Collagen proline hydroxylase in wound healing, granuloma formation, scurvy, and growth. Science. 157:927-9.
2. Suh SY, Bae WK, Ahn HY, Choi SE, Jung GC, Yeom, CH. Intravenous Vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial. Nutr J, 11(7).
3. Kim, Y, Kim H, Bae S, Choi J, Lim SY, Lee N, Lee, WJ. Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of influenza A virus (h4N2) infection. Immune network, 13(2), 70-74.
4. Uchide N, Toyoda H. Antioxidant therapy as a potential approach to severe influenza-associated complications. Molecules, 16(3), 2032-2052.
5. Hoffer LJ, Robitaille L, Zakarian R, Melnychuk D, Kavan P, Agulnik J, Miller Jr WH. High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial.
6. Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, Chen Q. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Science translational medicine, 6(222), 222ra18-222ra18.
7. Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Esteban MA. The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. Journal of Biological Chemistry, 289(6), 3339-3351.

High-Dose IV Vitamin C on ARDS by COVID-19: A Possible Low-Cost Ally With a Wide Margin of Safety

The following is reprinted, at the request of the author, from an article originally posted in Spanish to the IntraMed website.

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Intravenous vitamin C has been the object of numerous studies regarding its function as adjuvant therapy on critical
patients’ care, included ARDS of diverse etiology. In the context of a coronavirus pandemic, with an elevated
morbimortality and pressure over the sanitary system, it is of vital importance to use every available resource to
improve patients’ outcomes in an accessible and safe way. In this article, I briefly analyze the evidence around the
use of vitamin C in the critical patient and its potential benefits on admission time, intubation time and mortality on
patients affected by ARDS.

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Vitamin C was discovered in the 30s by Albert Szent-Györgyi. The first therapeutic function known was to treat scurvy, first described on ship crews who couldn’t access fresh fruits and vegetables during long seasons on the sea. Later on, Nobel Prize winner Linus Pauling performed numerous studies on the physiological and therapeutic effects of vitamin C, concluding that we were just beginning to understand its full potential. Humans are one of the few vertebrates that can’t synthesize vitamin C, therefore it is considered to be an essential nutrient. It’s estimated that 7% of the general population is deficient in vitamin C, but this percentage increases to 47% in admitted patients. ₍₁₎₍₂₎

Vitamin C’s enteral absorption is limited and its plasmatic levels are strictly regulated. A standard dietary intake maintains plasmatic levels around 70 ɥmol/L, but intensive oral supplementation of 3 grams a day only rises this level up to a maximum of 220 ɥmol/L. Therapeutic effects are achieved with plasmatic levels in the range of 20-49 mmol/L (100 times higher than those achieved by oral intake) only possible with intravenous infusion₍₃₎₍₄₎₍₅₎.

Evidence shows that the therapeutic effects take place with a minimum dose of 50mg/k/day and a maximum of 200mg/k/day, divided into four doses given every 6 hours. The largest randomized study performed so far, CITRIS-ALI ₍₆₎, found that vitamin C supplementation failed to modify biomarkers such as thrombomodulin, C reactive protein and organ failure scores (SOFA), but successfully reduced mortality by 16.5%, respiratory assistance requirements by 2.5 days, ICU stay by 3.2 days and hospital admission by 6.7 days, compared to placebo. This is more relevant than never in view of the worldwide shortages in beds and equipment. Some authors suggest that the reason why biomarkers weren’t modified was that the samples were taken at 96 hours, time when more severely ill patients had died and were excluded from the study (survivorship bias)₍₇₎₍₈₎. Two meta-analyses that included 685 and 147 critical patients concluded that intravenous vitamin C showed no adverse reactions, reduced the need for fluids and vasopressor support and reduced intubation time up to 25%₍₉₎₍₁₀₎.

A series of case reports on ADRS of diverse etiology (aspirative after seizures, inflammatory during a psoriasis flare-up, and viral) describes a fast improvement following vitamin C administration, even when the treatment was started after ECMO was required. In every case there was a symptomatic and radiologic improvement in 24-48 hours after the initial dose and good evolution at discharge, without signs of fibrotic sequels₍₁₁₎₍₁₂₎₍₁₃₎. Marik et. al. found a 30% mortality reduction in septic patients treated with vitamin C, hydrocortisone and thiamine, when compared to patients treated under standard procedures. In addition, the treated group required 50% less vasopressor support than the control group₍₁₄₎.

Regarding the evidence around vitamin C’s mechanisms of action, certain preclinical findings might explain the effects observed on respiratory distress. Vitamin C down-regulates inflammatory genes and inhibits the cytokine storm responsible for the activation of pulmonary neutrophils, therefore protecting alveolar capillaries from inflammatory damage. In addition to this, it enhances alveolary fluid clearance by increasing the water transporter channel expression₍₁₅₎₍₁₆₎.

In regards to its safety, most studies report no adverse effects on large doses of vitamin C. On rare occasions, the following have been described: Hypersensitivity, oxalate urolithiasis, iron overload in haemochromatosis and anaemia among others, most of them with a prevalence less than 1%. It has also been described the inaccuracy of bedside glucometry when using vitamin C and it is advised to corroborate findings with laboratory results₍₅₎₍₁₇₎₍₁₈₎₍₁₉₎.

We live in times of incalculable need. Worldwide medical supplies are in shortage, costs threat to crush even the wealthiest of health care systems, and above all the wellbeing of millions of humans is at risk. Treatment of severe ARDS from COVID-19 is an ongoing challenge and a specific treatment could be months ahead. The evidence around vitamin C is scarce but promising. There probably never was and never will be a better time than the current to explore and make use of every possible tool that could allow us to improve patients’ prognosis and expand the body of evidence for the benefit of all.

References

Schleicher, Rosemary L., et al. “Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004
National Health and Nutrition Examination Survey (NHANES).” The American journal of clinical nutrition 90.5 (2009): 1252-1263.
2. Fain, Olivier, et al. “Hypovitaminosis C in hospitalized patients.” European journal of internal medicine 14.7 (2003): 419-425.
3. Jacob, Robert A., and Gity Sotoudeh. “Vitamin C function and status in chronic disease.” Nutrition in clinical care 5.2 (2002): 66-74.
4. Padayatty, Sebastian J., et al. “Vitamin C pharmacokinetics: implications for oral and intravenous use.” Annals of internal medicine
140.7 (2004): 533-537.
5. Stephenson, Christopher M., et al. “Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose
intravenous ascorbic acid in patients with advanced cancer.” Cancer chemotherapy and pharmacology 72.1 (2013): 139-146.
6. Truwit, Jonathon D., et al. “Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in
patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial.” Jama 322.13 (2019): 1261-1270.
7. Spiegel, Rory. “Myths in Emergency Medicine: Vitamin C Trial Lacks Answers for Sepsis.” Emergency Medicine News 42.1 (2020):
1-32.
8. Hager, David N., Jeremiah S. Hinson, and Richard E. Rothman. “Vitamin C for Sepsis and Acute Respiratory Failure.” Jama 323.8
(2020): 791-792.
9. Zhang, Michael, and David F. Jativa. “Vitamin C supplementation in the critically ill: A systematic review and meta-analysis.” SAGE
open medicine 6 (2018): 2050312118807615.
10. Hemilä, Harri, and Elizabeth Chalker. “Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a metaregression
analysis.” Journal of Intensive Care 8.1 (2020): 15.
11. Marik, Paul E., et al. “Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective
before-after study.” Chest 151.6 (2017): 1229-1238.
12. Marik, Paul Ellis, and Ashleigh Long. “ARDS complicating pustular psoriasis: treatment with low-dose corticosteroids, vitamin C
and thiamine.” Case Reports 2018 (2018): bcr-2017.
13. Kim, C., et al. “Vitamin C infusion for gastric acid aspiration-induced acute respiratory distress syndrome (ARDS).” Pulm Res Respir
Med Open J 4.2 (2017): 33-37.
14. Fowler III, Alpha A., et al. “Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress
syndrome.” World journal of critical care medicine 6.1 (2017): 85.
15. Fisher, Bernard J., et al. “Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.” American
Journal of Physiology-Lung Cellular and Molecular Physiology 303.1 (2012): L20-L32.
16. Fisher, Bernard J., et al. “Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury.” Critical care medicine 39.6 (2011):
1454-1460.
17. Padayatty, Sebastian J., et al. “Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse
effects.” PloS one 5.7 (2010).
18. Canavese, Caterina, et al. “Long-term, low-dose, intravenous vitamin C leads to plasma calcium oxalate supersaturation in
hemodialysis patients.” American journal of kidney diseases 45.3 (2005): 540-549.
19. Hager, David N., et al. “Glucometry when using vitamin C in sepsis: a note of caution.” Chest 154.1 (2018): 228-229.

Vitamin C for facial skin – what is it, how to use it [SkinCeuticals expert opinion]

As you know, vitamin C is not synthesized in the body, but comes from food: citrus fruits, berries, tomatoes, peppers, rose hips. True, the skin does not always get it in the right amount. Even with the use of large doses, the absorption of the vitamin by the intestine is limited.

Important: when there is a deficiency of vitamin C, the more important organs are first “dismantled”, and it enters the skin according to the residual principle.That is why it is recommended to make up for the lack of a valuable substance with the help of cosmetics.

4 The use of vitamin C in cosmetics

Vitamin C’s ability to improve skin health and fight virtually all signs of aging has been known for many years. But to get its stable forms, working in creams to the maximum, they learned relatively recently. After all, ascorbic acid has the insidious property of rapidly oxidizing in air. Nowadays vitamin C is used in cosmetics in the form:

• L-ascorbic acid;
• grieved-6-palmitate;
• magnesium ascorbyl phosphate.

According to Dr. Sheldon Pinnell, founder of SkinCeuticals, a renowned chemist and dermatologist, the effectiveness of vitamin C in a cream depends on the formula. The cream works if:

• contains pure L-ascorbic acid;
• the concentration of ascorbic acid is 10–20%;
• has a PH of less than 3.5;
• includes substances that additionally enhance the effect of the vitamin (for example, ferulic acid belongs to them).

Modern technologies (for example, encapsulation) also help to create products with all forms of vitamin C.And a special sealed package that excludes contact with air.

5 Safety precautions

The use of ascorbic acid in cosmetic preparations has practically no contraindications. It is well tolerated on all skin types. However, sunscreen should be applied over bleaching or anti-aging vitamin C products.

6 SkinCeuticals Vitamin C Overview

High Performance Antioxidant Serum for Dry to Normal Skin CE Ferulic

Three powerful antioxidants help fight off the attack of free radicals and prevent premature aging:

1. pure L-ascorbic acid;
2. alpha-tocopherol;
3. Ferulic Acid.

After a month of application, the skin looks younger, elasticity increases, wrinkles become less noticeable, pigment spots brighten. Restores and prolongs the effect of cosmetic procedures.

Highly effective antioxidant serum for all skin types Serum 10

The product, containing 10% pure L-ascorbic acid and ferulic acid, perfectly copes with the effects of poor ecology and exposure to ultraviolet radiation. Smoothes wrinkles, stimulates collagen production, lightens dark spots.Apply 4-5 drops in the morning to cleansed skin.

Serum in Phloretin CF Gel

The serum-in-gel texture is in itself an excellent conductor of active substances into the skin. L-ascorbic and ferulic acids, phloretin reduce the manifestations of photoaging. The skin becomes even, without pronounced age spots, and wrinkles are reduced. It takes 2-3 pushes of the dispenser to obtain the volume required for one application. Apply to cleansed face and décolleté.

Antioxidant Eye Gel AOX + Eye Gel

Fights all sorts of problems of delicate eyelid skin: wrinkles, bags under the eyes, dark circles. It contains L-ascorbic and ferulic acids, phloretin, butcher’s root extract, caffeine. To squeeze out the required amount of gel, it takes 1-2 clicks, and when applying, it is necessary to step back 1-2 mm from the edge of the lower lashes.

Source: skin.ru

90,000 What are the benefits of injection therapy? Beauty salon Grail in Tver

Cosmetology is truly versatile: it offers many methods for your youth and beauty.Hardware, manual, injection … but each has many subspecies and varieties. Today we will talk about injection therapy and why it is still one of the most relevant and popular procedures among cosmetologists and their clients.

To begin with, let us designate that injection cosmetology is the introduction under the skin with the help of injections of special cosmetological solutions. It is used to solve a wide range of problems: skin rejuvenation, improvement of its quality, contour plastics, body shaping, elimination of cellulite, stretch marks and stretch marks, hair loss treatment.Cosmetic companies from all over the world release new drugs every year that will soon be able to cope with any aesthetic problem.

Procedures that use injections: contour plastics, fillers, ozone therapy, mesotherapy, biorevitalization, botulinum therapy (wrinkle smoothing and hyperhidrosis therapy).

What is special about injections?

Unlike cosmetic treatments, which act “from the outside” and do not affect the deep processes, injections penetrate directly into the tissues and act instantly and “from the inside”.If we talk about rejuvenation, then the mesotherapeutic drug launches the processes of synthesis of new collagen and elastin in the skin, saturates the tissues with the necessary substances. The result in this case is preserved for a longer period than from applying a cosmetic mask.

Other benefits of injection include:

• Slight trauma: after the procedure, only small punctures and redness remain on the skin, which disappear already on the 3rd day. In comparison, laser rejuvenation or peels damage the entire surface layer and the recovery process takes much longer.
• Individual approach: the composition and its quantity are selected individually by the cosmetologist each time, based on the characteristics of the client’s skin.
• Versatility: Can be injected anywhere on the body / face / scalp.
• Fast rehabilitation period: on average it takes 2-3 days and does not break the client’s usual schedule.

Features of injection techniques in cosmetology – DMC UDP RF

The article was prepared by: Zakharova Oksana, dermatovenerologist, cosmetologist, head of the department of dermatovenerology and cosmetology of the Federal State Budgetary Institution “Children’s Medical Center” of the Administrative Department of the Russian Federation,
Moscow:

The cosmetic industry is developing at a rapid pace, and the vector of development is aimed at finding means and methods that not only give a quick and noticeable result, but also have a persistent, and most importantly, complex effect. In this regard, in the field of, for example, injection cosmetology, a large number of new drugs appear that promise an incomparable effect, and their composition is so diverse that the fine line between mesotherapy, biorevitalization, bioreparation is not always tangible, the differences are not always clear.A natural question arises: what are the advantages of each of the injection procedures and which one is better to choose?

The history of injection techniques dates back to the 18th century, when the French surgeon Charles-Gabriel Pravas invented a method for injecting an active solution into tissues using a syringe with a hollow needle. Since then, the concept of mesotherapy, broad and multifaceted, unites all types of injections used in cosmetology (and not only).

Mesotherapy is just one of the ways to move towards the goal.And the goal itself is to achieve a pronounced result due to the most close to the problem and concentrated effect of the drug. And the main role in injection techniques is played by the drug (active substance), as well as the method and depth of its administration.

In the course of further scientific searches for the elixir of youth, injection cosmetology reached a new level. New drugs appeared, and then their complexes (meso cocktails) based on the pharmacological compatibility of the components and the direction of action.Within the framework of mesotherapy, vitamins, amino acids, trace elements, homeopathic extracts, elastin, collagen, plant extracts, acids, peptides remained as an independent procedure … As well as hyaluronic acid of animal (!) Origin and auxiliary substances (propylene glycol, sulfurous acid salt). The cocktail itself is liquid, the spectrum of action is wide, and the effect is general healing, rejuvenating.

In 2001, Italian scientists, observing the course of the wound process, found that hyaluronic acid, which is involved in excess in wound healing, stimulates a very intensive process of skin regeneration.This is how the biorevitalization method appeared – the introduction of hyaluronic acid preparations (stabilized and unstabilized) into different layers of the skin.

It is known that hyaluronic acid is an essential and indispensable component of the dermis. Over time, its amount decreases, and signs of tissue volume deficit, gravitational ptosis become visible on the skin, wrinkles appear, skin color changes, tone decreases, water balance is disturbed … As you can see, the lack of just one component is able to gradually but confidently transform a person’s appearance.And it is not only natural circumstances that can alter cellular metabolism, the structure and quality of the skin. This is also facilitated by exposure to ultraviolet rays and chemicals, endocrinological diseases and many other factors. Therefore, to restore the elasticity of the skin, strengthen their frame function, form a hydroreserve and, most importantly, to protect the skin from adverse effects, a new material was needed.

The powerful regenerating ability of non-animal (!) Hyaluronic acid, injected into different layers of the skin, depending on the concentration of the gel preparation, made it possible to separate biorevitalization into an independent procedure.Today this term is familiar to everyone who has ever consulted a beautician. A procedure that literally restores cells to life after any type of damage, including aging, has become the gold standard in aesthetic medicine.

The effect of biorevitalization comes quickly, but cannot persist for a long period. After all, hyaluronic acid introduced into the dermis in an unstabilized state is not able to stay in the tissues for a long time, since it undergoes enzymatic destruction by hyaluronidase, which is also contained in the dermis.Therefore, the search for the elixir of youth continued, the method of biorevitalization evolved, and a new procedure appeared – bioreparation.

The reparants are based on biosynthetic hyaluronic acid and the principle of biocompatibility and natural regeneration. Hyaluronic acid is not used in its pure form, as in the case of biorevitalization, but in combination with vitamins and amino acids. Such modified complexes of hyaluronic acid are less sensitive to hyaluronidase, therefore bioreparants are not subject to enzymatic degradation for 21 days.During this time, recovery processes are launched in the skin: molecules of biomodified acid stimulate collagen synthesis and the work of fibroblasts, restore damaged areas of DNA molecules, and inhibit melanogenesis.

So what to choose among the variety of injection methods? On the one hand, the answer to this question is simple. The choice depends on the problem that needs to be solved, on the age and on the financial capabilities of the patient. Those who are susceptible to allergic reactions can be advised to start the course with an injection of preparations based on pure (unmodified) hyaluronic acid.However, even for professionals, the question of choosing an injection scheme can be controversial. After all, we live in an age of high activity and employment. It happens that with a reasoned desire of the doctor to give the patient a full course of injectable skin rejuvenation, including mesotherapy, biorevitalization (or bioreparation), circumstances arise due to which the “protocol” course is violated and the doctor prefers a simplified but prolonged scheme.

When choosing a product, it is also important to determine the type of skin and assess its condition and age-appropriateness.

At the age of 26–35, as a rule, mimic wrinkles develop, the turgor of the skin decreases, and the complexion worsens. Until 30 years old, it is better to limit yourself to mesotherapy cocktails. If there are no signs of skin damage and dehydration, most often the effect of the procedures performed is sufficient. If there are signs of dryness, dehydration, photodamage of the skin, the client can be recommended two to five mesotherapy procedures, then two to four biorevitalization procedures with pure hyaluronic acid or two or three biorevitalization procedures with biomodified hyaluronic acid.

At the age of 35 to 40, the quality of the skin changes, tone, volume decreases, signs of gravitational ptosis appear. Signs of skin photodamage are common: hyperpigmentation, enlarged pores, rosacea. Along with contour plastics, volumetric modeling, botox injections, attention should be paid to mesotherapeutic cocktails. Usually, for this age category, all kinds of combinations of mesopreparations, biorevitalizants, bioreparants are offered. Often, patients have previously performed a similar set of procedures and can evaluate their effectiveness, which greatly facilitates the choice of a drug.

In the age group from 40 years old, much depends on the condition of the skin, the type of aging, the severity of gravitational ptosis, the depth of the folds. It is necessary to understand whether the patient had an operative plastic surgery of the face, what procedures were carried out earlier. Biorevitalization, as a rule, is considered as a stage of contour modeling, fractional thermolysis, radio wave lifting … It is better to give preference to mesotherapy or bioreparation.

As we can see, the line between procedures is thin, and circuits are unstable.This is because the skin of everyone who consults a cosmetologist has its own disadvantages and advantages. The task of the doctor is to correct deficiencies, replenish the deficiency of the most important components and prolong the youthfulness of the skin.

90,000 Does the skin need vitamins? – medical center “YOUR DOCTOR” Mine

Mesotherapy, known to everyone as “beauty injections” – is the introduction of cocktail solutions of vitamins, microelements, antioxidants and other medicinal substances into the skin. Unlike creams, masks, serums, mesotherapy delivers the necessary substances directly to the skin and activates the metabolism in cells.

Mesotherapy is a special technique of intradermal injection of medicinal products. They are injected directly into the area requiring correction. Injections are infrequent – once a week. Gradually, within a week, the drug is consumed for the needs of the body. This creates favorable conditions for tissue regeneration. In most cases, mesotherapy is used in cosmetology as a rejuvenating procedure.

Highly qualified doctors of the Center for Men and Women “Your Doctor” have extensive experience with injection techniques.When choosing a cocktail, your doctor will take into account the individual characteristics of the body. We use only high-quality drugs with certificates from leading world and domestic manufacturers.

Mesotherapy is an effective and safe procedure that is painless. To relieve discomfort, a special anesthetic cream is used.

What aesthetic disadvantages can mesotherapy solve?

Correction of age signs. One of the most effective methods for correcting age-related changes and preventing aging is face mesotherapy. We use preparations based on hyaluronic acid. Thanks to its action, the skin is smoothed in a natural way – rejuvenation does not require surgical intervention! Hyaluronic acid is a natural component of the human body, it helps to retain moisture in the skin. The hyaluronic acid technique is also called hyaluronic mesotherapy.Within a few days after the procedure, the first effect of skin rejuvenation is noticeable.

Hyperpigmentation. Meso-cocktails contain substances that destroy pigment and block excess pigment production, promoting rapid skin renewal.

Couperosis (vasculature). Mesotherapy is carried out with substances that strengthen the vascular wall.

Seborrhea. Used meso cocktails to reduce sebum production.

Correction of cellulite and excess weight. Mesotherapy is carried out with the use of special lipolytic (fat-dissolving) drugs, therefore it is also called injection lipolysis. The procedure promotes the breakdown of fats and their elimination from the body.

Correction of stretch marks and scars. Meso-cocktails accelerate the process of scar resorption. The skin is nourished with essential microelements that help to replace damaged tissues in the scar area.

Treatment of acne. Mesotherapy is an auxiliary procedure that allows you to quickly eliminate unpleasant rashes, contains anti-inflammatory components, removes stagnant spots after acne.

Treatment of hair and scalp. The procedure is actively used in trichology to solve the problems of rare, split ends.

Preparation and rehabilitation after chemical peels, as well as laser resurfacing, plastic surgery.

How is the procedure performed?

The course of face and body mesotherapy is selected individually, as well as a cocktail for each problem area. For injections, certified drugs are used. Preparations for face mesotherapy are injected into the skin to a depth of 0.5-4 mm using short thin needles, for lipolytic body mesotherapy into the subcutaneous fat at a depth of 10-12 mm.

What is the effect of the procedures?

The procedure improves the color, firmness and elasticity of the skin.The introduced meso-cocktail normalizes the metabolism in the skin and the synthesis of new cells. And this ensures that the new skin cells are healthy and “correct”.

How long is the recovery period after the procedure?

The next day after face mesotherapy, you can return to your usual way of life.

At what age can the procedure be performed?

There are no age restrictions.

How many procedures do you need?

The recommended course includes 5-10 procedures with a break of 1 week.You can find out the prices for mesotherapy on our website. Also, this method is well combined with other cosmetic procedures, such as botulinum therapy, plasma-lifting, contouring and thread lifting.

Where can you get mesotherapy?

For consultation with a cosmetologist and the procedure, we invite you to the Center for Men’s and Women’s Health “Your Doctor” at the address: st. Shevchenko, 153g, phone for appointment: 8 (938) 111-62-11, 8 (8636) 22-44-33.You can make an appointment through the button below:

Mesotherapy in Astana, the cost of injection mesotherapy – VICLINICS

Mesotherapy is a modern injection method for solving a number of cosmetic imperfections and age-related skin changes. It allows you to effectively fight high fat content, pigmentation, rosacea, acne, hair loss, cellulite and many other changes.

The method is based on the principle of local treatment of skin diseases by introducing the necessary mesotherapeutic drugs (cocktails) as close as possible to the problem area.At the same time, different preparations are used to solve different problems – vitamins, trace elements, amino acids, peptides, antibacterial agents and other bioactive components. Based on the composition of the meso cocktail, the price of mesotherapy procedures in Astana varies.

Injection mesotherapy: advantages

• Individual approach to elimination of deficiencies. The composition of the preparations is determined based on the indications: antibacterial and adsorbing agents are administered to the patient to combat skin inflammations, moisturizing agents are introduced to increase turgor and smooth wrinkles.It is also possible to carry out complex treatment using several components
• No age restrictions. Mesotherapy is used to eliminate various skin imperfections, it can be performed at almost any age
• Rapid rehabilitation. Since it is a non-invasive method, recovery from the procedure takes place in a very short time. In most cases, injection marks disappear within a few hours.
• Long-term effect. The result fully justifies the cost of a course of mesotherapy.The effect of the procedure lasts up to 10 months or more, depending on the individual characteristics of the patient’s skin.

cosmetology mesotherapy: conducting

Before the start of the procedure, the cosmetologist conducts a preliminary consultation with the patient. This is necessary to identify the patient’s problem, methods for its elimination, possible contraindications and determine the composition of mesopreparations. Immediately before the manipulation, deep cleansing of the skin is carried out in the area where the drug will be injected.Then an anesthetic cream is applied for 30 minutes.

The drug is injected into the mesoderm (middle layer of the dermis) with a thin needle to a depth of 1 to 4 mm. The number and depth of injections are determined individually, based on the problem being solved. For example, when treating cellulite, drugs are injected deep into the hypodermis. And hair mesotherapy for the treatment of alopecia (hair loss), seborrhea and increased fat content of the scalp, preparations with active ingredients are injected directly into the dermis in the area of ​​hair follicle growth.The duration of the course, the composition of the preparations and the price of mesotherapy for hair, face and body depends on what problem needs to be solved.

Mesotherapy for the face: indications

• Decreased skin elasticity and skin turgor
• The appearance of expression and age wrinkles
• Acne, enlarged pores
• Couperose
• Post-acne (spots, post-acne scars)
• Pigmentation of various origins
• Hair loss
• Seborrhea (dandruff)
• Increased oiliness of the scalp
• Local body fat
• Cellulite

Result of mesotherapy

Using this method, you can achieve the following results:

• Smooth expression lines and make static (age) wrinkles less pronounced
• Eliminate acne and acne
• Smooth the skin in the area of ​​acne scars, make it smoother
• Even out skin tone, sharpen facial contours
• Stop hair loss and provoke their active growth
• Get rid of excess oily scalp and dandruff
• Reduce body fat

course of face mesotherapy: contraindications

Despite the local nature and safety of mesotherapy, it has a number of contraindications:

• Chronic and acute renal failure
• Cardiological and oncological diseases
• Acute infectious and viral diseases
• Blood clotting disorders
• Pregnancy and lactation

Before the procedure, the specialist conducts a test for the patient’s tolerance to the components of the drug in order to exclude an allergic reaction.

Mesotherapy for face: skin care after the procedure

At the end of the session, the specialists of the ANNA Vi CLINICS Medical Center advise the patient in detail on skin care in the area of ​​manipulation. This service is, of course, included in the cost of face, hair and / or body mesotherapy. Maintenance No special steps are usually required, but it is important to observe the following guidelines:

• Apply doctor-prescribed regenerating cream for 3-5 days
• 10 days do not use scrub or peel procedures
• 10 days do not visit the sauna, bathhouse and pool
• Do not sunbathe for a month and be sure to apply sunscreen before going outside (SPF 30 or more)

Of all the modern methods of rejuvenating and combating skin imperfections, “beauty injections” are among the most popular.This is due to the proven effectiveness of the method – the result of the procedures is noticeable after the first session. And after a full course, which can include from 5 to 15 procedures, the skin literally transforms, looks younger, healthier and fresher. The cost of mesotherapy for face, hair, and body is fully justified by the result.

Sign up for a consultation with the specialists of the ANNA Vi CLINICS medical center right now and see for yourself!

90,000 advantages and methods of the procedure.

What is face mesotherapy?

Procedures of modern injection cosmetology have almost completely “replaced” non-invasive care procedures. Very often, our cosmetologists recommend to patients such an effective injection procedure as mesotherapy.

The method of mesotherapy is based on the introduction of a preparation under the skin, individually selected by a cosmetologist to solve specific problems depending on skin type, age and sensitivity to certain ingredients.For the procedure, both a ready-made composition and an individually prepared meso-cocktail can be used.

Mesotherapy improves the quality of the skin, fights pigmentation, acne and post-acne. The procedure is also effectively used in trichology to treat various types of alopecia. However, in the correction of age-related changes, this technique is more of a preventive nature, therefore, it is advisable to carry it out until 30-35 years old.

It should also be borne in mind that for a visible result it is necessary to complete a course of at least 3-4 procedures.Despite some painfulness of the procedure, the effectiveness and excellent results after undergoing a course of mesotherapy are worth a little discomfort.

Benefits of mesotherapy

The effect of mesotherapy is achieved through the use of a fine mechanical injection needle and the introduction of the active components of the drug under the skin with its help. Due to the receipt of many microtraumas during the procedure, blood circulation improves, elastin and collagen are actively produced.

The technique effectively fights against age-related skin changes and aesthetic defects: eliminates rosacea, acne, improves complexion, reduces skin porosity, increases skin turgor, brightens age spots and has a lifting effect. The procedure can also be performed on the body to eliminate cellulite, stretch marks and scars.

As a result of mesotherapy, a therapeutic cocktail enters the skin, which is distributed by cells throughout the body. That is why mesotherapy has a beneficial effect not only on the transformation of the appearance, but also has a healing effect on the body as a whole.

Advantages of mesotherapy
– The procedure can be performed at any age, both for women and men.
– Safe and non-toxic composition of meso cocktails.
– High skin sensitivity of beneficial cocktail formulations.
– Ultra-thin needles make the procedure virtually painless and deliver minimal discomfort to the patient.
– Long-term stable result up to 1.5 years.
– The procedure has practically no contraindications.
– It is carried out on an outpatient basis.
– The procedure is perfectly combined with other methods of cosmetic treatment.
– No seasonal restrictions.

The procedure can be carried out at any time of the year, subject to the subsequent protection of the face from direct sunlight and refusal to visit the solarium for a week before and after the procedure.

Components for meso cocktails

Phospholipids. Components capable of restoring the elasticity of cell membranes.

Vitamins. Depending on the needs of the skin, either separately A, C, B, E, P, or several at once.

Minerals. Such as zinc, phosphorus, sulfur, help with acne skin problems.

Plant and animal extracts. The former include: gingko biloba and gingocofeine, the latter – collagen and elastin, which maintain skin elasticity.

Synthesized components. These artificial ingredients are found in most mesotherapy cocktails. For example, the most popular hyaluronic acid is able to moisturize and smooth the skin as quickly as possible.

Organic acids. For example, glycolic acid at a certain concentration.

Technique of the procedure

Before the procedure, a consultation with a cosmetologist is required.

The method of carrying out mesotherapy can be either hardware or manual. The choice of technique is carried out by the cosmetologist depending on the type of patient’s skin, as well as on the specific area where the injections will be injected.

The manual method is more balanced with respect to the physiological structure of certain areas of the face and body, therefore, this method can be used to work more delicately and accurately the most sensitive areas, for example, around the mouth or eyes. In particular, the manual method of mesotherapy is indicated for owners of thin skin.

Apparatus mesotherapy usually makes injections less painful. Also, the method of hardware introduction of mesotherapy is effective for eliminating cellulite.

Before the mesotherapy procedure, the cosmetologist will pre-prepare the skin by applying anesthetic for 20-30 minutes to minimize possible pain. This will be followed by cleansing the skin. Then he will start injecting the drug into the skin with an ultra-thin needle. The depth of needle insertion is no more than 5 mm.The number of injections done is quite large, so the duration of the procedure is 20-30 minutes.

Injections contain small dosages of the active ingredients of the drug – no more than 0.2 ml of the active substance. The center of distribution of mesococktails is strictly controlled by a doctor.

The beautician will complete the mesotherapy procedure by applying a soothing mask. The restoration of the skin after the session occurs quite quickly, but it is necessary to adhere to the doctor’s recommendations, namely: refrain from using decorative cosmetics, do not touch your face with your hands, and also do not visit the bathhouse, sauna or solarium for a week after the procedure.

The transformation effect can be noticed immediately after the first procedure, and it is recommended to repeat the course 1-2 times a year. Do not forget that it is forbidden to carry out the procedure on your own at home, it can only be carried out by cosmetologists. Lack of professional skills and improper execution technique can lead to hospitalization. In addition, there is a great risk of causing irreversible damage to the appearance, the consequences of which are difficult, and sometimes impossible, to correct.

Possible side effects after the procedure

PAPULES. A couple of days after the procedure, there will be small seals at the injection sites, which will go away on their own. Don’t be scared – this is a normal skin reaction.

Slight swelling or bruising. During mesotherapy, the skin receives many microtraumas, so it is possible that an ultra-thin needle can accidentally get into the capillary and redness or a small bruise will occur.

Also, in some cases, an allergic reaction to the drug may occur.

Contraindications for mesotherapy

But, like any cosmetic procedure, mesotherapy has some limitations and contraindications.
– Pregnancy and lactation.
– Inflammation of the face.
– Recent chemical peel.
– Exacerbation of herpes.
– Cholelithiasis.
– Diabetes mellitus.
– Epilepsy.

The cost of mesotherapy in Krasnodar

The cost of the procedure depends on the composition of the cocktail and the problem of each patient.Depending on the age and the problem, the number of procedures will vary from 4 to 10 sessions. You can get acquainted with the cost of mesotherapy at the Symmetria clinic in the Price List section.

Mesotherapy will be effective only if the procedure is performed by a professional cosmetologist. Only certified, competent specialists with extensive work experience work in our clinic.

Our cosmetologists will select the meso-cocktail that is optimal for you, based on the condition of your skin, as well as the presence of contraindications.In their work, our doctors use only high-quality certified drugs, which minimizes the risk of possible side effects after the procedure and guarantees an excellent result.

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90,000 Injection cosmetology.Cosmetologist services. Cosmetology in Moscow

Injection cosmetology is one of the most effective ways of tightening and rejuvenating the skin of the face, neck, décolleté, hands, in which active substances are delivered to the body using injections. The advantages of injection procedures in cosmetology are instant effect, minimization of allergic reactions and the absence of long-term rehabilitation. And it is also possible to combine procedures with other methods of treatment.

Contour correction 1.5 ml.)

902 ) (upon purchase of 3 procedures, the 4th as a gift)

Contour correction
Contour correction Juviderm ultra 2 (0.5 ml.)	10100 rub
Contour correction Juviderm Ultra 3 (0.8 ml)	18000 rub
Contour correction Juviderm Voluma (1.0 ml)	20000 rub
Contour correction 4 (1 ml)	18000 rub
Radiesse contour correction (0.8 ml)	14000 rub
Revanesse Redexis contour correction (1ml)	21500 rub
17500 rub
Contour correction Radiesse (3.0 ml.)	22000 rub
Contour correction Surgiderm 30 XP (0.8 ml)	15000 rub
Contour correction Xiderm24 (0.8 ml)	14000 rub
Contour correction Restylane Perlane (0.5 ml)	14500 rub
Contour correction Restylane Perlane (1.0 ml)	16500 rub
Contour Correction Genyal Volumae (1.0 ml)	15500 rub
Contour correction Genyal Polyvalent (1.0 ml)	15000 rub
Contour correction Teosyal RHA1	20000 rub
Contour correction Teosyal RHA1	20000 rub 18000 rub
Soprano contour correction (1ml)	14500 rub
Belotero intense contour correction (1ml)	21000 rub
	439
904 facial wrinkle and contour correction	Botox 1 unit	350 rubles
Relatox 1 unit	320 rubles
Dysport 1 unit	150 rubles
Correction of hyperhidrosis – botox (up to 80 units.- for 1 unit)	320 RUB
Correction of hyperhidrosis – botox (over 80 units – for 1 unit)	300 RUB
Bioreparation
nucle D	12000 rub
D nucleo Tre	13000 rub
D nucleo Sei	10500 rub
D nucleo Uno	10000 rub
9016
scalp	3000 rub
Dermaheal SR (rejuvenation) – 1.0 ml.	1200 rub
Dermaheal LL (lipolytic) – 1.0 ml.	1200 RUB
Dermaheal Dark Circle Solushen (from dark circles) – 1.5 ml.	3000 rub
Dermaheal Eyebag Studion (for hernias) – 1.5 ml.	3000 rub
Dermaheal SB (clarification) -1.0 ml.	1200 rub
Electroporation (non-injection mesotherapy)	3000 rub
Using PRP for surgical procedures	3000 rub
Plasmolifting 904 9039 Pirma 9039 9039 9039 9039 9039 9039 9039 9039 9039
Plasma therapy enriched with hyaluronic acid 1 tube	8500 rub
Plasmolifting 2 tubes	7000 rub
Plasmolifting
Plasmolifting 904 tubes	15000 rubles

 FREE WITH ANNUAL ATTACHMENT 

Doctors

The appearance of wrinkles and other signs of aging directly depends on the content of collagen and hyaluronic acid in the skin, which only decreases with age.However, with the help of special drugs, you can slow down the aging process. The method successfully removes existing skin defects and prevents the appearance of new ones. In the same way, you can enter into the dermis and other biologically active substances and vitamins.

How does injection rejuvenation with fillers go

Using a thin needle, the cosmetologist injects the drug, leveling the skin relief from the inside. In this way, you can not only slow down the aging process, but also give a certain shape to the lips or other parts of the face.The type of filler and the depth of exposure are determined depending on the problem being solved. The result of the procedure is visible immediately. There is no rehabilitation period as such. Usually, the swelling lasts a couple of hours, and the injection marks are almost invisible.

Injection cosmetology services:

How is injectable elimination of wrinkles with the help of muscle relaxants

Muscle relaxants (Botox, Dysport, Relatox, Xeomin). Once in the muscle, they block nerve impulses and relax the desired area.As a result, muscles stop contracting at the injection sites, wrinkles are completely smoothed out. Muscle relaxants are successfully used to eliminate excessive sweating.

Contact us to:

• Get rid of the deepest wrinkles with the help of muscle relaxants (Botox, Dysport, Relatox, Xeomin).
• Quickly and successfully cope with fat deposits using Lipotherapy. This is a kind of drugs with a natural composition.The basis is lycithin, this component is found in many foods, it is also produced by the body.
• Saturate the skin with hyaluronic acid and breathe new life into it during biorevitalization and bioreparation.
• Return youth and health with the help of placental biorevitalization.
• Conduct mesotherapy and forget about your biological age.
• To make volumetric or contour plastic using injections.
• Do plasma therapy or plasmoplasty based on your own blood plasma.