Is aleve and naproxen the same. Aleve vs Naproxen: Understanding the Similarities and Differences
Is Aleve the same as Naproxen. Why is one available over-the-counter while the other requires a prescription. What are the key differences between Aleve and Naproxen in terms of dosage, uses, and effectiveness.
The Active Ingredient: Naproxen Sodium
Aleve and prescription naproxen share the same active ingredient: naproxen sodium. This compound belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, substances in the body that cause inflammation, pain, and fever.
What sets naproxen sodium apart from other NSAIDs?
- Longer duration of action (up to 12 hours)
- Effective for both acute and chronic pain conditions
- Particularly useful for menstrual cramps and arthritis pain
Over-the-Counter vs Prescription: What’s the Difference?
The primary difference between Aleve and prescription naproxen lies in their dosage and availability. Aleve is available over-the-counter (OTC) in lower doses, while prescription naproxen is typically prescribed at higher strengths for more severe or chronic conditions.
Aleve (OTC Naproxen Sodium)
- Available without a prescription
- Typically 220 mg per tablet
- Intended for short-term use (up to 10 days for pain, 3 days for fever)
- Suitable for mild to moderate pain and inflammation
Prescription Naproxen
- Requires a doctor’s prescription
- Available in higher doses (250 mg, 375 mg, 500 mg)
- Can be prescribed for longer-term use under medical supervision
- Used for more severe or chronic conditions
Common Uses and Indications
Both Aleve and prescription naproxen are used to treat a wide range of conditions characterized by pain and inflammation. However, the specific indications may vary based on the dosage and formulation.
Aleve (OTC) Uses
- Headaches
- Menstrual cramps
- Toothaches
- Backaches
- Minor arthritis pain
- Muscular aches
- Temporary fever reduction
Prescription Naproxen Uses
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Gout
- Tendonitis
- Bursitis
- Chronic lower back pain
- Juvenile rheumatoid arthritis
It’s important to note that while the uses overlap, prescription naproxen is often used for more severe cases or when long-term treatment is necessary.
Effectiveness and Duration of Action
How do Aleve and prescription naproxen compare in terms of effectiveness? Both formulations contain the same active ingredient, so their mechanism of action is identical. However, the higher doses available in prescription naproxen may provide more potent pain relief for severe conditions.
Duration of Action
One of the key advantages of naproxen sodium, whether in Aleve or prescription form, is its long duration of action. A single dose can provide relief for up to 12 hours, making it a popular choice for conditions that require sustained pain management.
Onset of Action
How quickly does naproxen start working? Generally, you can expect to feel relief within:
- 20-30 minutes for liquid formulations
- 1-2 hours for tablets or capsules
The full anti-inflammatory effects may take several days to reach their maximum potential, particularly when treating chronic conditions.
Safety Considerations and Side Effects
While Aleve and prescription naproxen are effective pain relievers, they come with potential risks and side effects that users should be aware of. The risk of adverse effects may increase with higher doses and prolonged use, which is why prescription naproxen requires medical supervision.
Common Side Effects
- Stomach upset or pain
- Heartburn
- Nausea
- Headache
- Dizziness
- Drowsiness
Serious Side Effects
While less common, more serious side effects can occur, especially with long-term or high-dose use:
- Gastrointestinal bleeding or ulcers
- Increased risk of heart attack or stroke
- Kidney problems
- Allergic reactions
- Liver damage (rare)
It’s crucial to follow dosage instructions carefully and consult a healthcare provider if you need to use naproxen for an extended period.
Drug Interactions and Precautions
Naproxen, whether in Aleve or prescription form, can interact with various medications and medical conditions. It’s essential to be aware of these potential interactions to ensure safe usage.
Common Drug Interactions
- Other NSAIDs (including aspirin)
- Blood thinners (e.g., warfarin)
- Certain antidepressants (SSRIs)
- ACE inhibitors and ARBs (blood pressure medications)
- Diuretics
- Methotrexate
Precautions
Certain individuals should use naproxen with caution or avoid it altogether:
- People with a history of stomach ulcers or gastrointestinal bleeding
- Those with heart disease or high blood pressure
- Individuals with kidney or liver problems
- Pregnant women, especially in the third trimester
- People with asthma or allergies to aspirin or other NSAIDs
Always consult a healthcare provider before starting naproxen if you have any of these conditions or are taking other medications.
Choosing Between Aleve and Prescription Naproxen
When deciding between Aleve and prescription naproxen, several factors come into play. Here are some considerations to help guide the choice:
When to Choose Aleve (OTC Naproxen)
- For occasional, mild to moderate pain
- Short-term use (up to 10 days)
- Minor injuries or inflammation
- Menstrual cramps
- Headaches or toothaches
When Prescription Naproxen May Be Necessary
- Chronic conditions like arthritis or back pain
- Severe acute pain
- When higher doses are required for effective relief
- Long-term treatment under medical supervision
- Management of inflammatory conditions like gout or tendonitis
It’s important to remember that while Aleve is available without a prescription, it should still be used responsibly and according to the label instructions. If pain persists or worsens, consult a healthcare provider.
Cost Considerations and Availability
The cost and availability of Aleve versus prescription naproxen can vary significantly. Understanding these differences can help in making an informed decision.
Aleve (OTC Naproxen)
- Generally more affordable due to its OTC status
- Available in various retail outlets without a prescription
- Often comes in larger quantities suitable for occasional use
- May be covered by flexible spending accounts (FSAs) or health savings accounts (HSAs)
Prescription Naproxen
- Requires a doctor’s prescription
- May be more expensive, especially without insurance coverage
- Often available in generic form, which can be more cost-effective
- Typically covered by health insurance plans, subject to copays or deductibles
- Available in various formulations (tablets, capsules, liquid)
When considering long-term use, it’s worth discussing the cost implications with your healthcare provider or pharmacist. They may be able to suggest more affordable alternatives or ways to reduce costs.
Alternative Pain Relief Options
While naproxen is an effective pain reliever, it’s not the only option available. Depending on the type and severity of pain, alternative treatments may be more suitable.
Other OTC Pain Relievers
- Acetaminophen (Tylenol): Effective for pain and fever, but not inflammation
- Ibuprofen (Advil, Motrin): Another NSAID with similar effects to naproxen
- Aspirin: Useful for pain and inflammation, but with different side effect profile
Non-Medication Alternatives
For some types of pain, non-pharmacological approaches can be effective:
- Physical therapy
- Hot or cold therapy
- Massage
- Acupuncture
- Exercise and stretching
- Mindfulness and relaxation techniques
Combining these approaches with medication can often provide more comprehensive pain management. Always consult with a healthcare provider to determine the best treatment plan for your specific condition.
Conclusion: Making an Informed Decision
Understanding the similarities and differences between Aleve and prescription naproxen is crucial for making informed decisions about pain management. While both contain the same active ingredient, their availability, dosage, and intended uses differ significantly.
Key takeaways:
- Aleve and prescription naproxen both contain naproxen sodium as the active ingredient
- Aleve is available over-the-counter in lower doses for short-term use
- Prescription naproxen offers higher doses for more severe or chronic conditions
- Both forms can be effective for pain and inflammation, but carry potential risks and side effects
- The choice between OTC and prescription naproxen depends on the severity and duration of symptoms, as well as individual health factors
Always consult with a healthcare provider if you’re unsure which option is best for your situation, especially if you have ongoing pain or other health concerns. They can help you weigh the benefits and risks, consider alternative treatments, and develop a safe and effective pain management plan tailored to your needs.
Aleve vs Naproxen Comparison – Drugs.com
Aleve vs Naproxen Comparison – Drugs.com
Skip to main content
Enter another drug to compare |
|---|
Related suggestions Pain
Osteoarthritis
Rheumatoid Arthritis
Back Pain
Popular comparisons
| |||||||||
| More about Aleve (naproxen) | More about Naproxen | ||||||||
| Generic Status | |||||||||
Lower-cost generic is available | Lower-cost generic is available | ||||||||
| Ratings & Reviews | |||||||||
Aleve has an average rating of | Naproxen has an average rating of | ||||||||
View all 151 reviews | View all 669 reviews | ||||||||
| Drug Class | |||||||||
|
| ||||||||
| Side Effects | |||||||||
See also: Aleve side effects in more detail. | See also: naproxen side effects in more detail. | ||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all | ||||||||
Get free Discount Card | Get free Discount Card | ||||||||
| Dosage Form(s) Available | |||||||||
|
| ||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.  | |||||||||
18 hours | 18 hours | ||||||||
| CSA Schedule ** View glossary of terms | |||||||||
Is not subject to the Controlled Substances Act. | Is not subject to the Controlled Substances Act. | ||||||||
| Pregnancy Category | |||||||||
See the full pregnancy warnings document. | See the full pregnancy warnings document. | ||||||||
| Drug Interactions | |||||||||
A total of 410 drugs are known to interact with Aleve:
| A total of 410 drugs are known to interact with naproxen:
| ||||||||
| Alcohol/Food/Lifestyle Interactions | |||||||||
|
| ||||||||
| Disease Interactions | |||||||||
|
| ||||||||
| First Approval Date | |||||||||
January 11, 1994 | March 11, 1976 | ||||||||
| WADA Class View World Anti-Doping Agency classifications.  | |||||||||
N/A | N/A | ||||||||
| More Information | |||||||||
|
| ||||||||
| Patient resources | |||||||||
|
| ||||||||
| Professional Resources | |||||||||
N/A |
| ||||||||
It should not be used from week 20 of pregnancy.</p>
<p>
Prescribed for Back Pain, Ankylosing Spondylitis, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout – Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.
</p>
<p>
May also be
prescribed off label for Aseptic Necrosis, Herniated Disk.
</p>
”>
..
0 out of 10 from a total of
Do not drink alcohol while taking…** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law.
There may be variations in CSA schedules between individual states.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Top 9 Things You Must Know About Naproxen
Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 9, 2022.
Generic Name: naproxen (na PROX en), naproxen sodium (na PROX en SOW de um)
Common Proprietary Names: Aleve (tablets, caplets, gelcaps, liquid gels), Anaprox-DS, EC-Naprosyn, Flanax Pain Reliever, Midol IB, Naprelan, Naprosyn. Naproxen is also available in combination with other products as: Aleve PM, Aleve-D Sinus and Cold, Treximet, and Vimovo
How often do you need pain relief? If you suffer from low back pain, an aching knee, strained muscles, arthritis, throbbing headaches, tooth pain or any other myriad of painful conditions, you are not alone. It is estimated that chronic pain (pain lasting over 3 months) affects more than 100 million Americans.
In fact, pain affects more Americans than diabetes, heart disease and cancer combined.
Medications in the class of drugs known as NSAIDs (nonsteroidal anti-inflammatory drugs) are the workhorse of pain and fever relief for millions of people. Not surprisingly, NSAIDs are one of the most commonly used class of drugs in the world.
Available in various formulations with or without a prescription, NSAIDs work to relieve inflammation and pain by inhibiting cyclooxygenase and reducing prostaglandin production – in other words, blocking a mechanism of pain. However, this pain relief does not come without important warnings for effective and safe use of naproxen products.
1. Naproxen and naproxen sodium are available in many forms
You can take naproxen orally by tablet, capsule or as a liquid suspension, in an extended-release formulation, surrounded by an enteric coating, combined with a proton pump inhibitor to help protect your stomach, with a decongestant to relieve sinus pressure, or even combined with an antimigraine medicine or an agent to help you sleep.
You can get it with a prescription, or without.
Naproxen comes in two forms – either as the base naproxen or as the salt form naproxen sodium. Both the base and salt forms work the same way to relieve pain. There is one difference — naproxen base on a milligram-per-milligram basis is slightly stronger than naproxen sodium. Here’s how it works out — 220, 275, or 550 mg of naproxen sodium equals 200, 250, and 500 mg of naproxen, respectively. However, you don’t need to worry about any conversion as these slight differences are already taken into account when the dose is determined. Just follow your directions on the label.
2. Familiar naproxen products:
Over-the-counter (OTC) naproxen sodium:
- Aleve
- Pamprin All Day
- Midol Extended Relief
- Aleve-D Sinus & Cold (naproxen sodium and pseudoephedrine) – combined with a decongestant
Prescription-only names of naproxen sodium include:
- Anaprox DS
- Naprelan
Prescription-only names of naproxen base include:
- EC-Naprosyn
- Naprosyn
Other combos:
- Vimovo (esomeprazole and naproxen): helps protect against ulcers
- Treximet (naproxen sodium and sumatriptan): for acute migraine headache
3.
Save money: naproxen comes in generic options
Naproxen and its salt formulation have been around for a long time. In fact, the FDA approved the first formulations of naproxen sodium in 1980. That’s good news, because formulations of many naproxen and naproxen sodium drugs are now available generically, saving you dollars at the pharmacy.
For example, you can easily use the generic OTC naproxen to get the same pain relief as you would from the more expensive prescription brands. Just be sure to ask your doctor what the equivalent OTC dose would be based on your indication. The OTC products come in a lower strength than many prescription options, so you may need to take a higher OTC dose.
Naproxen is available over-the-counter (OTC) for relief of menstrual cramps, but generics work just as well and save you money, too. For menstrual cramps, it may be less expensive to use the generic or store brand naproxen sodium than the branded products, so it’s worth a comparison. Be sure to check the package size, too, to be sure you are getting a good deal.
Learn more: Top 10 Ways to Save Money on Your Medication Costs
4. Naproxen has many uses in many different age groups
Naproxen and its sodium salt are used for many different types of pain, and it is an excellent fever reducer, too. Below are just some of the common uses for naproxen:
- Osteoarthritis
- Rheumatoid arthritis
- Dental work and toothache
- Ankylosing spondylitis
- Acute gout
- Dysmenorrhea (menstrual cramps)
- Fever
- General muscle pain and inflammation, like back pain
- Headaches
The safety and effectiveness of naproxen is not known in children less than 2 years of age. The over-the-counter (OTC) products are only labeled for children 12 years and older.
If deemed appropriate, a doctor can prescribe some formulations for children as young as 2 years of age for:
- fever
- mild to moderate pain
- juvenile rheumatoid arthritis.
You must first check with your doctor to use any form of naproxen in children under 12 years of age.
Naproxen should be used cautiously and at the lowest possible dose (if at all) in the elderly, especially those at risk for, or with a history of stomach, heart or intestinal ulcers or bleeding.
5. Is naproxen safe for the heart?
You may have heard that naproxen is safer for the heart compared to other NSAIDs like ibuprofen, diclofenac, meloxicam, or celecoxib; however, this is a controversial topic.
The FDA has determined that the available studies are not robust enough and were not designed to determine if one NSAID was safer than any other with respect to heart safety (cardiovascular thrombotic events). The FDA has stated that “based on available data, it is unclear whether the risk for cardiovascular thrombotic events is similar for all non-aspirin NSAIDs.”
In addition, when determining the safety of a drug for a patient, risk factors such as age, other medical conditions, other medications and drug interactions, doses needed, and duration of treatment need to be taken into consideration.
Since 2005, labeling laws have required a boxed warning on all NSAIDs alerting of increased cardiovascular risks, like heart attack and stroke. That warning was a result of the withdrawal of the NSAID Vioxx (rofecoxib) from the market in 2004 because of a notable increased risk of heart attack among Vioxx users. Celebrex (celecoxib), another COX-2 selective NSAID, is still on the U.S. market.
The heart warning on all NSAID labels state that this class may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (like a heart attack or stroke). The risk may occur early in treatment, be greater if you already have heart problems or if you take NSAIDs for a long period of time. Additionally, the label warns that NSAIDs should not be used (they are contraindicated) right before or after coronary artery bypass graft (CABG) surgery.
6. Can NSAIDs hurt my stomach?
Boxed warnings on naproxen labels also alert patients to an increased risk of serious and sometimes fatal stomach or intestine ulcers, bleeding and perforation.
Elderly patients (those over 65 years of age) and those with a history of ulcer disease or bleeding in the digestive tract may be at a greater risk. This effect can occur without any warning signs.
NSAIDs may also worsen intestinal diverticulitis. Patients with a history of diverticulitis should speak with their doctor about the safety of using NSAIDs.
You should avoid using aspirin and other anticoagulants (blood “thinners”) with NSAIDs, for example:
- warfarin
- Eliquis (apixaban)
- Xarelto (rivaroxaban)
- Pradaxa (dabigatran)
Check with your doctor before you combine blood thinners with NSAIDs, as you may increase your risk for serious bleeding.
7. Be sure: check your naproxen drug interactions
Be sure to alert your pharmacist and physician of all of the medications you take, so that they can screen for clinically significant drug interactions with naproxen, even if you buy it over-the-counter (OTC).
Over 400 drugs are known to interact with naproxen. Naproxen also has several food and alcohol interactions you should take note of and discuss with your pharmacist. You can also review significant disease interactions that may be affected by the use of naproxen, like high blood pressure.
Always check drug interactions with all of your prescription, over-the-counter, and vitamin or herbal products, too.
8. Pregnant? Speak with your doctor before NSAID use.
It is important that you ask your doctor for advice before taking any drug in pregnancy. This applies to NSAIDs, too, even the ones bought over-the-counter.
For mild pain and headaches in pregnant women, most physicians usually recommend acetaminophen (Tylenol).
Use of NSAIDs at 20 weeks’ gestation or later may cause kidney problems in the baby or low amniotic fluid volume (oligohydramnios). Naproxen (and all other NSAIDs) should be avoided in pregnancy (usually during the third trimester) because it may cause premature closure of the ductus arteriosus, which can lead to heart failure and death of the fetus.
Other problems may occur too.
9. Join the naproxen support group
Support groups on Drugs.com may be helpful for patients who use medications for pain relief, have multiple conditions, and who are searching for the latest news. In fact, pain is one of the top medical condition support groups on Drugs.com. Joining one or more support groups is a great way to discover others with similar conditions or using related medications, and to share your own experience.
There are close to 700 user reviews for naproxen from people who use this drug for arthritis, back pain, headache and other various conditions (some of which may be off-label use, meaning the drug is not approved by the FDA for that particular use). Here you can ask a question, share an experience, browse through the latest blog posts and questions, and see other ratings from patients who are using naproxen.
Remember, the information is NOT intended to endorse naproxen or recommend drug therapy. While these reviews might be helpful to you, they are NOT a substitute for the expertise, skill, knowledge and judgement of your healthcare provider.
Learn more
- Advil Dosage Charts for Infants and Children
- Dosage Charts for Infants and Children
- Motrin Dosage Charts for Infants and Children
- Pain / Fever Drugs and Alcohol Interactions
- Pain Management: Types of Pain and Treatment Options
- Tramadol – Top 8 Things You Need to Know
- Tylenol Dosage Charts for Infants and Children
- Understanding Opioid (Narcotic) Pain Medications
Treatment options
- Medications for Ankylosing Spondylitis
- Medications for Dental Abscess
- Medications for Fever
- Medications for Gout, Acute
- Medications for Headache
- Medications for Menstrual Disorders
- Medications for Oral and Dental Conditions
Care guides
- Acetaminophen and Ibuprofen Dosing in Children
- Acute Headache
- Acute Headache in Children
- Ankylosing Spondylitis
- Arthritis
- Chronic Post Traumatic Headache
- Chronic Post Traumatic Headache in Children
Symptoms and treatments
- Ankylosing spondylitis
- Fever
- Headache
- Osteoarthritis
- Pain
Medicine.
com guides (external)
- Arthritis Guide
- Dental Abscess Guide
- Osteoarthritis Guide
Sources
- FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. Accessed Feb. 9, 2021 at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory
- Aleve. Bayer. Frequently Asked Questions. Accessed Feb. 9, 2022 at https://www.aleve.com/faq/dosage/
- Naproxen. ASHP Monograph. Drugs.com. Accessed Feb. 9, 2022 at https://www.drugs.com/monograph/naproxen.html
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Naproxen vs Ibuprofen: Differences, Similarities & Which is Best for You – Drug Vs.
Friend
Home >> Drug Vs. Friend >> Naproxen vs Ibuprofen: Differences, Similarities and Which is Best for You
Drug Vs. Friend
Drug Overview and Key Differences | Conditions of treatment | Efficiency | Insurance coverage and cost comparison | Side effects | Drug Interactions | Warnings | FAQ
Naproxen and ibuprofen are NSAIDs (non-steroidal anti-inflammatory drugs) used to treat pain and inflammation in a variety of conditions. NSAIDs block a chemical called prostaglandin. Prostaglandin causes pain and inflammation. By blocking prostaglandin, NSAIDs help reduce pain and inflammation. Both naproxen and ibuprofen are known as NSAIDs and have many similarities but some differences.
What are the main differences between naproxen and ibuprofen?
Naproxen, or naproxen sodium, is known under the brand name Naprosyn and is also sold over the counter as Aleve. It is also only available in generic form (prescription and over-the-counter at a lower dose) and in combination with other medications.
Ibuprofen is known under the brand names Motrin and Advil and is also available in generic form alone and in combination with other medications. The dosage depends on the indication and the over-the-counter dose is lower than the prescription dose. In addition, ibuprofen has a shorter duration of action and is dosed more frequently than naproxen, which takes longer to act and may be administered less frequently.
Because both drugs are available in a variety of combinations, such as many different cough and cold medicines, and sleep formulations, it is a good idea to check with your pharmacist when choosing an over-the-counter product to ensure you are choosing the right product for your symptoms. In addition, many combination products containing naproxen or ibuprofen may contain a product that may not be compatible with your medical condition or other medicines you are taking.
When choosing a medicine for children, always consult your pediatrician or pharmacist about the appropriate dosage depending on the age and weight of the child.
| Main differences between naproxen and ibuprofen | ||
|---|---|---|
| Naproxen | Ibuprofen 4 | |
| Drug class | NSAID | NSAID |
| Brand/generic status | Brand and generic | Brand and generic |
| What is a brand? | Alev, Anaprox DS, Naprosin | Motrin, Advil |
| What form(s) does the drug come in? | Tablets, caplets, soft gels | Tablets, caplets, soft gels, liquid forms |
| What is the standard dosage? | Over-the-counter adults: 220 mg every 8 to 12 hours. Adults Rx: 250-500 mg every 12 hours. * Take with food | Over-the-counter adults: 200 mg every 4-6 hours (maximum 1200 mg per day). Adults Rx: 400-800 mg 3-4 times daily (maximum 3200 mg daily – consult physician). * Take with food |
| How long does a typical treatment last? | Depends on indication | Depends on indication |
| Who usually takes this medicine? | Adults, children 2 years and older | Adults, children 6 months and older |
Want a better price on ibuprofen?
Sign up for ibuprofen price alerts and find out when prices change!
Get price alerts
Conditions treated with naproxen and ibuprofen
Naproxen and ibuprofen are two popular medicines used to treat pain and inflammation. Both drugs are indicated for the relief of signs and symptoms of rheumatoid arthritis, osteoarthritis, mild to moderate pain, and primary dysmenorrhea (menstrual cramps). Naproxen is also indicated for the relief of symptoms of tendinitis, bursitis, acute gout, ankylosing spondylitis, and polyarticular juvenile idiopathic arthritis.
| Condition | Naproxen | Ibuprofen |
| Rheumatoid arthritis Osteoarthritis | yes | yes |
| Tendinitis Bursitis Acute gout | yes 9003 4 | Not by prescription |
| Ankylosing spondylitis Polyarticular juvenile idiopathic arthritis | yes | Off label |
| Mild to moderate pain | yes | yes |
| Primary dysmenorrhea | yes | yes |
Is naproxen or ibuprofen more effective?
Two randomized, double-blind, placebo-controlled studies comparing naproxen with ibuprofen for osteoarthritis of the knee studied both drugs for one week at OTC (lower) doses and found that both drugs were effective in reducing pain. Naproxen has been found to be slightly more effective and more effective at reducing nighttime pain.
Both drugs were well tolerated.
Another small study comparing naproxen and ibuprofen found that both drugs helped reduce stiffness, rest pain, movement pain, night pain, disease interference with daily activities, and overall disease severity. In this study, naproxen was found to be more effective. Many patients have experienced side effects, mostly mild gastrointestinal problems; however, one patient on naproxen did experience gastrointestinal bleeding.
After a 20-year review of NSAIDs, the authors acknowledged the difficulty of choosing an NSAID and stated that the choice of analgesic is often based on personal experience rather than evidence. They go on to say that most studies are for acute rather than chronic conditions, and that these studies cannot effectively determine which NSAID is best. The authors emphasize the importance of using the lowest dose of NSAIDs for the shortest possible time. They recommend that when Tylenol (acetaminophen) isn’t enough, it’s best to start with a low dose of ibuprofen (along with stomach protectant medications for those at high risk of gastrointestinal effects).
Since the evidence is rather inconclusive, the most effective medicine should be determined by your doctor, who will take into account your condition and medical history, as well as other medicines you may be taking.
Want a better price for naproxen?
Sign up for naproxen price alerts and be notified when the price changes!
Get price alerts
Naproxen and ibuprofen coverage and cost comparison
Naproxen and ibuprofen are available at reasonable prices in both OTC and prescription versions. Both drugs are usually covered by insurance and Medicare Part D in the form of prescription drugs. A typical prescription for naproxen is 60 500mg tablets and costs about $30-$40 without insurance. A typical prescription for ibuprofen is 30 800mg tablets and costs about $18 without insurance. Co-payments for health insurance and Medicare Part D vary by plan. You can save money by using the SingleCare coupon for naproxen and ibuprofen.
| Naproxen | Ibuprofen covered by insurance? | Yes – prescription only | Yes – prescription only | |
| Usually covered by Medicare Part D? | Yes – Prescription only | Yes – Prescription only | ||
| Standard dosage | #60 500mg tablets | #30 800 mg tablets | ||
| Standard Medicare Part D copay | $0-20 | $0-22 | ||
| Cost SingleCare | $9-$20 | 5 –$8 |
Side effects of naproxen versus ibuprofen
Since naproxen and ibuprofen are NSAIDs, the side effects of both drugs are similar. The most common side effects are gastrointestinal (GI) which include heartburn, abdominal pain, constipation and/or diarrhea. Some patients also experience nausea, dizziness, or headaches.
Consult your doctor for a complete list of side effects.
| Naproxen | Ibuprofen Side effect | Applicable? | Frequency | Applicable? | Frequency | |
| Heartburn | yes | 3-9% | yes | 1-16% | ||
| yes | 3-9% | yes | 1-16% | |||
| Abdominal pain | yes | 3-9% 900 34 | yes | 1-16% | ||
| Constipation | yes | 3-9% | yes | 1-16% | ||
| 031 1-16% | ||||||
| Headache | yes | 3-9% | yes | 1-3% | ||
| Dizziness | yes | 3-9% | yes | 3-9% | ||
| Drowsiness | yes | 3-9% | no | – | ||
| Itching (itching) | yes | 3-9% | yes | 3-9% | ||
| Tinnitus (ringing in the ears) | 3-9% | yes | 1- 3% | |||
| Edema (swelling) | yes | 3-9% | yes | 1-3% | No | – |
Source: DailyMed ( naproxen), DailyMed (ibuprofen)
Naproxen and ibuprofen drug interactions
Naproxen or ibuprofen should not be taken with anticoagulants such as coumadin (warfarin) as this may increase the risk of bleeding.
Taking naproxen or ibuprofen with other NSAIDs, such as aspirin, may also increase the risk of bleeding as well as gastrointestinal side effects. Naproxen or ibuprofen can interact with many blood pressure medications, including ACE inhibitors, angiotensin receptor blockers, beta-blockers, and diuretics. Both drugs also interact with several classes of antidepressants, which can cause (potentially life-threatening) bleeding as well as low sodium levels. Consult your healthcare professional for a complete list of drug interactions. 9
Other NSAIDs
Vasotek (enalapril)
Avapro (irbesartan)
Benicar (olmesartan)
Diovan (valsartan) 90 034
Toprol XL (metoprolol)
Tenormin (atenolol)
Celexa (citalopram)
Paxil (paroxetine)
Prozac (fluoxetine)
Zoloft (sertraline)
Pamelor (nortriptyline)
Pristiq (desvenlafaxine)
Cymbalta (duloxetine)
ibuprofen
Because both naproxen and ibuprofen are NSAIDs, they have the same warnings:
- There is a boxed warning (the strongest warning required by the FDA):
- Cardiovascular thrombotic events, such as heart attack or stroke, which may be fatal. The risk may occur early in treatment and increase with longer use.
- The use of naproxen or ibuprofen is contraindicated during CABG.
- There is an increased risk of gastrointestinal bleeding, ulcers or perforation of the stomach or intestines, which can be potentially fatal. It could happen at any moment and without warning. Elderly patients or patients with a history of peptic ulcer and/or gastrointestinal bleeding are at higher risk. Because of these risks, patients should use the lowest dose for the shortest possible time.
- Cardiovascular thrombotic events, such as heart attack or stroke, which may be fatal.
- NSAIDs should not be used in patients with a previous history of allergic reactions such as asthma, rash or anaphylaxis due to the risk of a severe, potentially fatal anaphylactic reaction in these patients.
- Patients should not take NSAIDs after a heart attack.
- There is a small risk of liver toxicity; Patients should be aware of signs such as nausea, fatigue, lethargy, diarrhea, itching, jaundice, right hypochondrium tenderness, and flu-like symptoms, and seek emergency care if symptoms occur.
- Hypertension (high blood pressure) may develop or worsen.
- NSAIDs should not be used in patients with heart failure.
- Prolonged use may cause kidney damage. Patients should monitor renal function and not use NSAIDs if renal function is impaired.
- Patients with asthma, nasal polyps and aspirin sensitivity (aspirin sensitive asthma) should avoid NSAIDs.
- Serious skin reaction that may include exfoliative dermatitis, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)m, which can be fatal and occur without warning. Patients should stop taking NSAIDs and seek treatment if signs of a skin reaction appear.
- Anemia occurred in patients treated with NSAIDs; Patients should be monitored for signs or symptoms of anemia.
- NSAIDs, by reducing inflammation and fever, may make it difficult to diagnose infections.
- Patients taking long-term NSAIDs should be monitored periodically with a complete blood count and chemical profile.
- NSAIDs should not be used in pregnant women from 30 weeks of gestation (third trimester) as they may cause premature closure of the fetal ductus arteriosus. During the first and second trimester, check with your doctor. NSAIDs can also interfere with ovulation; check with your doctor if you are trying to conceive.
The risk may occur early in treatment and increase with longer use.
Frequently asked questions about naproxen and ibuprofen
What is naproxen?
Naproxen is an NSAID (non-steroidal anti-inflammatory drug) used to treat pain and inflammation. It is available in both brand-name and generic forms, as well as prescription and over-the-counter.
What is ibuprofen?
Ibuprofen is also an NSAID that relieves mild to moderate pain and inflammation. It is available in both brand-name and generic forms with a prescription or over-the-counter.
Are naproxen and ibuprofen the same thing?
Both drugs are FDA approved NSAIDs. Because both are NSAIDs, naproxen and ibuprofen have a lot in common but also have some differences.
See above for details. Other NSAIDs include: Celebrex (celecoxib, a COX-2 inhibitor), Mobic (meloxicam), aspirin, and relafen (nabumetone). Tylenol (acetaminophen) is not an NSAID, but can often be found next to NSAIDs on the shelf. Tylenol helps with fever and pain, but does not treat inflammation.
Is naproxen or ibuprofen better?
As discussed above, naproxen and ibuprofen are similar and both may be effective in reducing pain and inflammation. They have similar side effects and risks. Often the question of which medicine is best for you depends on your personal preference. Consult with your physician.
Can I use naproxen or ibuprofen during pregnancy?
Naproxen, ibuprofen or any NSAIDs should not be used during the third trimester of pregnancy as they may cause premature closure of the fetal ductus arteriosus. Since information on the use of NSAIDs in women at other stages of pregnancy is not enough, consult your obstetrician-gynecologist. If you are currently taking naproxen or ibuprofen and find out you are pregnant, talk to your doctor.
Can I use naproxen or ibuprofen with alcohol?
No. Taking naproxen or ibuprofen and drinking alcohol can significantly increase the risk of gastritis (inflammation of the lining of the stomach) and gastrointestinal bleeding.
What happens if you take naproxen and ibuprofen together?
Do not take naproxen and ibuprofen together. Check your shortcuts; Better yet, ask your pharmacist, especially for combination products, to make sure you only take one NSAID at a time. Taking both can increase the risk of side effects, as well as bleeding and stomach ulcers.
Is naproxen a muscle relaxant or pain reliever?
Naproxen does not technically relax muscles; it is a pain reliever and also helps with inflammation. Some popular muscle relaxants include Flexeril (cyclobenzaprine) or Skelaxin (metaxalone). This can be confusing because while naproxen is not technically a muscle relaxer, it can help mild to moderate muscle pain, which is why people sometimes think of it as a muscle relaxer.
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University
According to the Order of the Ministry of Health and Social Development of the Russian Federation No. 434 dated April 28, 2012, on October 1, 2012, the reorganization of the state budgetary educational institution of higher professional education “Volgograd State Medical University” of the Ministry of Health and Social Development of the Russian Federation and the state budgetary educational institution of higher professional education was completed “Pyatigorsk State Pharmaceutical Academy” of the Ministry of Health and Social Development of the Russian Federation in the form of joining the second institution to the first one with subsequent formation of a separate subdivision (branch) on the basis of the affiliated institution.
It was determined that the full name of the branch of the university (the former Pyatigorsk State Pharmaceutical Academy), taking into account the division of the Ministry of Health and Social Development of the Russian Federation into two ministries, is as follows:
Pyatigorsk Branch of the State Budgetary Educational Institution of Higher Professional Education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation
Abbreviated name: “Pyatigorsk branch of GBOU VPO VolgGMU of the Ministry of Health of Russia” .
According to the Order of the Ministry of Health of the Russian Federation No. 51 dated February 04, 2013, changes are indicated that are being made to the charter of the state budgetary educational institution of higher professional education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation.
In clause 1.10 paragraphs three and four shall be stated as follows:
“full name: Pyatigorsk Medical and Pharmaceutical Institute – branch of the state budgetary educational institution of higher professional education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation “,
short name:
“ Pyatigorsk Medical and Pharmaceutical Institute – branch of GBOU VPO VolgGMU of the Ministry of Health of Russia “.
Renaming was made from 14.03.2013.
In accordance with the order of the University of July 15, 2016 No. 1029-KM “On the introduction of a new edition of the Charter and changing the name of the University” from 07/13/2016 in connection with the renaming of the University count:
– with the full name of the University: federal state budgetary educational institution of higher education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation;
– abbreviated name of the University: FSBEI HE VolgGMU of the Ministry of Health of Russia;
– the full name of the branch of the University: Pyatigorsk Medical and Pharmaceutical Institute – a branch of the federal state budgetary educational institution of higher education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation;
– abbreviated name of the branch of the University: Pyatigorsk Medical and Pharmaceutical Institute – branch of the Federal State Budgetary Educational Institution of Higher Education VolgGMU of the Ministry of Health of Russia.