Is clindamycin effective for treating ear infections. What are the potential side effects of clindamycin. How should clindamycin be taken for optimal results. What precautions should be considered when using clindamycin for ear infections.

Understanding Clindamycin: An Overview of the Antibiotic

Clindamycin is a powerful antibiotic belonging to the lincomycin class of medications. It is primarily used to combat various bacterial infections, including those affecting the lungs, skin, blood, and internal organs. The drug’s mechanism of action involves inhibiting bacterial growth, making it an effective treatment option for a wide range of conditions.

While clindamycin is not typically the first-line treatment for ear infections, it may be prescribed in certain situations. Understanding its uses, benefits, and potential risks is crucial for patients and healthcare providers alike.

How does clindamycin work against bacterial infections?

Clindamycin works by interfering with the protein synthesis of bacteria, effectively halting their growth and reproduction. This mechanism allows the body’s immune system to overcome the infection more easily. It’s important to note that clindamycin, like other antibiotics, is not effective against viral infections such as colds or flu.

Clindamycin and Ear Infections: Efficacy and Applications

While clindamycin is not commonly prescribed as the first choice for ear infections, it may be used in specific cases. Ear infections can be caused by various bacteria, and the choice of antibiotic depends on factors such as the severity of the infection, the patient’s medical history, and local antibiotic resistance patterns.

Can clindamycin effectively treat ear infections?

Clindamycin can be effective in treating certain types of ear infections, particularly when other antibiotics have failed or are contraindicated. It may be prescribed for:

• Chronic or recurrent ear infections
• Infections caused by penicillin-resistant bacteria
• Cases where patients are allergic to more commonly used antibiotics

However, it’s crucial to note that clindamycin should only be used when necessary, as it carries a higher risk of certain side effects compared to other antibiotics.

Dosage and Administration of Clindamycin

Proper administration of clindamycin is essential for its effectiveness and safety. The medication is available in both capsule and liquid forms, allowing for flexibility in dosing based on the patient’s age and condition.

How should clindamycin be taken for optimal results?

To ensure the best outcomes when taking clindamycin:

1. Follow the prescribed dosage carefully, typically three to four times daily
2. Take the medication at evenly spaced intervals throughout the day
3. Complete the entire course of antibiotics, even if symptoms improve
4. Take capsules with a full glass of water to prevent throat irritation
5. Shake the liquid form well before each use to ensure proper mixing

It’s important to maintain consistent dosing times to maintain an effective concentration of the antibiotic in the body. If a dose is missed, take it as soon as remembered, unless it’s close to the time for the next dose. In that case, skip the missed dose and continue with the regular schedule.

Potential Side Effects and Risks of Clindamycin

While clindamycin can be highly effective against bacterial infections, it’s associated with a higher risk of certain side effects compared to other antibiotics. Understanding these potential risks is crucial for patients and healthcare providers when considering its use.

What are the most common side effects of clindamycin?

Common side effects of clindamycin may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain or discomfort
• Skin rash or itching
• Metallic taste in the mouth

While these side effects are generally mild, patients should report any persistent or severe symptoms to their healthcare provider promptly.

Is there a risk of serious complications with clindamycin use?

One of the most significant concerns with clindamycin use is the potential for developing Clostridioides difficile infection (C. diff), a severe intestinal condition. Clindamycin has a higher association with C. diff compared to many other antibiotics. Symptoms of C. diff infection may include:

• Severe, persistent diarrhea
• Abdominal pain or cramping
• Fever
• Blood or mucus in the stool

Patients should be aware of these symptoms and seek immediate medical attention if they occur during or after treatment with clindamycin, even up to several months after completing the course.

Precautions and Considerations When Using Clindamycin

Given the potential risks associated with clindamycin, certain precautions should be taken when considering its use, especially for ear infections.

Who should exercise caution when taking clindamycin?

Particular care should be taken in the following cases:

• Patients with a history of gastrointestinal disorders, especially colitis
• Individuals with liver or kidney disease
• Pregnant or breastfeeding women
• Patients with allergies to lincomycin or other related antibiotics

It’s crucial for patients to provide a comprehensive medical history to their healthcare provider before starting clindamycin treatment. This information helps in assessing the risks and benefits of using this antibiotic.

Alternative Treatments for Ear Infections

Given that clindamycin is not typically the first-line treatment for ear infections, it’s important to consider other options that may be more suitable in many cases.

What are common alternatives to clindamycin for ear infections?

Several other antibiotics are more commonly prescribed for ear infections, including:

• Amoxicillin
• Azithromycin
• Cefdinir
• Augmentin (amoxicillin/clavulanate)

These medications often have a lower risk profile and may be more appropriate for treating typical ear infections. The choice of antibiotic depends on various factors, including the patient’s age, medical history, and the suspected bacterial cause of the infection.

The Importance of Antibiotic Stewardship

The use of antibiotics like clindamycin highlights the crucial need for responsible antibiotic use, known as antibiotic stewardship. This practice aims to optimize antibiotic use to improve patient outcomes while minimizing the development of antibiotic resistance.

How can patients contribute to antibiotic stewardship?

Patients can play a vital role in promoting responsible antibiotic use by:

1. Only taking antibiotics when prescribed by a healthcare professional
2. Completing the full course of antibiotics as prescribed
3. Not sharing antibiotics with others or using leftover antibiotics
4. Discussing the necessity of antibiotics with their healthcare provider, especially for conditions that may be viral in nature
5. Practicing good hygiene to prevent the spread of infections

By following these principles, patients can help ensure that antibiotics remain effective for future use and reduce the risk of antibiotic-resistant infections.

Monitoring and Follow-up During Clindamycin Treatment

When prescribed clindamycin for an ear infection or any other condition, proper monitoring and follow-up are essential to ensure the best possible outcomes and minimize risks.

What should patients monitor during clindamycin treatment?

During the course of clindamycin treatment, patients should:

• Track their symptoms and note any improvements or worsening
• Be aware of potential side effects and report them promptly
• Maintain open communication with their healthcare provider
• Complete the full course of antibiotics unless instructed otherwise by a medical professional

If symptoms persist or worsen after a few days of treatment, it’s important to consult with the prescribing healthcare provider. They may need to reassess the treatment plan or consider alternative options.

When should patients seek immediate medical attention?

While taking clindamycin, patients should seek immediate medical care if they experience:

• Severe or persistent diarrhea
• Signs of an allergic reaction (such as rash, itching, or difficulty breathing)
• Severe abdominal pain
• Yellowing of the skin or eyes (jaundice)
• Any other unusual or severe symptoms

Prompt attention to these symptoms can help prevent serious complications and ensure appropriate medical intervention if needed.

Clindamycin in the Context of Broader Antibiotic Use

Understanding clindamycin’s role in the broader spectrum of antibiotic treatments is crucial for both healthcare providers and patients. While it’s a powerful tool against certain bacterial infections, its use must be carefully considered in the context of other available options.

How does clindamycin compare to other antibiotics in terms of efficacy and risks?

Clindamycin’s efficacy and risk profile can be compared to other antibiotics as follows:

• Broader spectrum of activity compared to penicillins, making it effective against a wide range of bacteria
• Higher risk of C. difficile infection compared to many other antibiotics
• Effective against some antibiotic-resistant strains, making it valuable in certain cases
• May have more gastrointestinal side effects than some other antibiotics

These factors contribute to clindamycin’s position as a second-line or alternative treatment option for many infections, including ear infections. Its use is often reserved for cases where other antibiotics are ineffective or contraindicated.

Future Perspectives on Antibiotic Use and Ear Infection Treatment

As medical research advances and our understanding of bacterial infections evolves, the approach to treating ear infections and the role of antibiotics like clindamycin may change.

What emerging trends might affect future ear infection treatments?

Several developments could impact future treatments for ear infections:

• Increased focus on antibiotic stewardship and targeted therapy
• Development of new antibiotics with improved efficacy and safety profiles
• Advancements in rapid diagnostic tests to identify specific bacterial strains
• Growing interest in non-antibiotic treatments and preventive measures
• Research into the role of the microbiome in ear health and infection susceptibility

These trends may lead to more personalized and effective treatments for ear infections, potentially reducing the need for broad-spectrum antibiotics like clindamycin in many cases.

Conclusion: Balancing Efficacy and Safety in Ear Infection Treatment

While clindamycin can be an effective treatment for certain ear infections, its use must be carefully considered due to the associated risks and the availability of alternative treatments. Healthcare providers must weigh the potential benefits against the risks for each individual patient, taking into account factors such as the severity of the infection, the patient’s medical history, and local patterns of antibiotic resistance.

Patients prescribed clindamycin for an ear infection should follow their healthcare provider’s instructions carefully, be vigilant for potential side effects, and complete the full course of treatment unless directed otherwise. Open communication between patients and healthcare providers is crucial for ensuring the safe and effective use of this powerful antibiotic.

As research continues and our understanding of bacterial infections and antibiotic use evolves, treatment approaches for ear infections may change. However, the principles of responsible antibiotic use and individualized patient care will remain central to effective and safe treatment strategies.

Clindamycin: MedlinePlus Drug Information

pronounced as (klin” da mye’ sin)

To use the sharing features on this page, please enable JavaScript.

Many antibiotics, including clindamycin, may cause overgrowth of dangerous bacteria in the large intestine. This may cause mild diarrhea or may cause a life-threatening condition called colitis (inflammation of the large intestine). Clindamycin is more likely to cause this type of infection than many other antibiotics, so it should only be used to treat serious infections that cannot be treated by other antibiotics. Tell your doctor if you have or have ever had colitis or other conditions that affect your stomach or intestines.

You may develop these problems during your treatment or up to several months after your treatment has ended. Call your doctor if you experience any of the following symptoms during your treatment with clindamycin or during the first several months after your treatment has finished: watery or bloody stools, diarrhea, stomach cramps, or fever.

Talk to your doctor about the risks of taking clindamycin.

Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria.

Antibiotics such as clindamycin will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

Clindamycin comes as a capsule and a solution (liquid) to take by mouth. It is usually taken three to four times a day. The length of your treatment depends on the type of infection you have and how well you respond to the medication. Take clindamycin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clindamycin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

Take the capsules with a full glass of water so that the medication will not irritate your throat.

You should begin to feel better during the first few days of treatment with clindamycin. If your symptoms do not improve or if they get worse, call your doctor.

Take clindamycin until you finish the prescription, even if you feel better. If you stop taking clindamycin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Clindamycin is also sometimes used to treat acne and is used along with other medications to treat anthrax (a serious infection that may be deliberately spread as part of a terror attack) and malaria (a serious infection that is spread by mosquitoes in certain parts of the world). Clindamycin is also sometimes used to treat ear infections, tonsillitis (infection that causes swelling of the tonsils), pharyngitis (infection that causes swelling in the back of the throat), and toxoplasmosis (an infection that may cause serious problems in people who do not have healthy immune systems or in unborn babies whose mothers are infected) when these conditions cannot be treated with other medications. Clindamycin is also sometimes used to treat bacterial vaginosis (an infection caused from too much of certain bacteria in the vagina). Clindamycin is also sometimes used to prevent endocarditis (infection of the heart valves) in certain people who are at risk of developing this infection as a result of a dental procedure. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking clindamycin,

• tell your doctor and pharmacist if you are allergic to clindamycin, lincomycin (Lincocin), any other medications, or any of the ingredients in clindamycin capsules or solution. Ask your pharmacist for a list of the ingredients. If you will be taking clindamycin capsules, tell your doctor if you are allergic to aspirin or tartrazine (a yellow dye found in some medications).
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S, E-Mycin, Erythrocin, others), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizoral), nefazodone, nelfinavir (Viracept), rifampin (Rifadin, in Rifamate, in Rifater, Rimactane), and ritonavir (Norvir, in Kaletra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with clindamycin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
• tell your doctor if you have or have ever had asthma, allergies, eczema (sensitive skin that often becomes itchy or irritated) or kidney or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking clindamycin, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clindamycin.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Clindamycin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• vomiting
• unpleasant or metallic taste in the mouth
• joint pain
• pain when swallowing
• heartburn
• white patches in the mouth
• thick, white vaginal discharge
• burning, itching, and swelling of the vagina

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

• peeling or blistering skin
• rash
• hives
• itching
• difficulty breathing or swallowing
• hoarseness
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• yellowing of the skin or eyes
• decreased urination

Clindamycin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not refrigerate clindamycin liquid because it may thicken and become hard to pour. Dispose of any unused clindamycin liquid after 2 weeks.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Cleocin^®

Last Revised – 05/15/2018

Browse Drugs and Medicines

What is clindamycin used for? Types, dosage, and side effects

Clindamycin is an antibiotic. It works to treat bacterial infections when penicillin is not an option. A doctor may recommend clindamycin for certain respiratory infections, lung infections, blood poisoning, and more.

Clindamycin is an antibiotic drug. Doctors prescribe clindamycin to treat bacterial infections in certain situations.

The drug comes in several different forms. These are:

• oral capsules
• topical creams, lotions, and gels
• intravaginal suppositories
• injections and intravenous drips

Depending on the type of infection and the dosage of clindamycin, the drug can either kill or stop the growth of bacteria.

Topical clindamycin is a common treatment option for acne and bacterial infections in the vagina. Doctors also use clindamycin to treat infections in people with penicillin allergies.

Clindamycin is not suitable for everyone, however, and it can cause a range of serious side effects.

This article looks at some uses, dosages, and symptoms of clindamycin. It also explores types and alternatives.

Doctors use clindamycin to treat a variety of bacterial infections. They prescribe it when they cannot use penicillin and when they have determined the type of bacteria involved in the infection.

This is because the form of clindamycin the doctor prescribes depends on the kind of infection the person has.

A doctor may prescribe clindamycin in the form of oral capsules or dissolvable granules for:

• respiratory infections with streptococci, pneumococci, and staphylococci bacteria
• empyema, anaerobic pneumonitis, or an abscess in the lung
• blood poisoning
• infections from anaerobic bacteria in the gut, resulting in peritonitis or an abscess in the abdomen
• endometriosis, pelvic cellulitis, an abscess in the reproductive system, or a vaginal cuff infection

A doctor may prescribe intravenous or injectible clindamycin for serious infections, such as:

• respiratory infections
• lung infections
• blood poisoning
• infections in the reproductive system
• abdominal infections
• bone and joint infections, and they may sometimes prescribe it alongside other medications during surgery for chronic bone and joint infections
• serious skin infections

A doctor may prescribe clindamycin for children as an oral solution to treat:

• serious respiratory infections
• serious infections of the skin or soft tissue
• blood poisoning
• infections in the abdomen
• infections in the female reproductive tract

A dermatologist may prescribe clindamycin in the form of a gel, solution, or lotion to treat acne.

A doctor may prescribe clindamycin in the form of a transvaginal suppository to treat bacterial vaginal infections. Alternatively, they may prescribe a clindamycin lotion for vaginal infections. Pregnant people in their second and third trimesters can use the lotion.

Some people can also take clindamycin for uses that the Food and Drug Administration (FDA) has not formally approved. Sometimes, for example, doctors use clindamycin to treat anthrax and malaria.

Dentists also use clindamycin as a preventive treatment for endocarditis, which is an infection of the heart’s lining that can occur after a dental procedure in people who are at risk.

Before having surgery, some people receive clindamycin to prevent surgical site infections.

There are four forms of clindamycin: injectable, intravaginal, oral, and topical.

The following table lists the forms of clindamycin along with their dosages in milligrams (mg), milligrams per milliliter (mg/ml), or percentages.

Dosage for capsules

The dosages for clindamycin capsules for adults are:

• for serious infections, 150–300 mg every 6 hours
• for more severe infections, 300–450 mg every 6 hours

The dosages for children who can swallow capsules are:

• for serious infections, 8–16 mg per kilogram (mg/kg) per day, divided into three or four equal doses
• for more severe infections, 16–20 mg/kg per day, divided into three or four equal doses

Dosage for suppositories

One suppository pill contains 100 mg of clindamycin. People can use this form once daily at bedtime for 3 consecutive nights.

Dosage for topical gels and lotions

Doctors prescribe Clindagel 1% to be applied once daily to the affected area.

Dosage for injectable clindamycin

The following table includes the dosages for injectable clindamycin in mg/kg per day and mg per day.

The form and dosage of clindamycin that a doctor prescribes will depend on the infection a person has.

How to take oral capsules and granules

Doctors should only prescribe clindamycin to people who have allergies to penicillin or if they suspect that a different antibiotic would be inappropriate for that person. This is to lower the risk of colitis, which is inflammation of the colon’s inner lining.

If possible, the doctor should take samples from the infection site to determine which bacteria are causing the infection.

Clindamycin capsules may irritate the esophagus, which is the tube that runs from the mouth to the stomach. To prevent this irritation, people may wish to take clindamycin capsules with a full glass of water.

For people who have difficulty swallowing, clindamycin comes in granules that dissolve in water.

How to use vaginal creams and suppositories

Topical clindamycin can help treat bacterial infections in the vagina.

The cream comes with an applicator. A person can insert the amount of one applicator, which is around 100 mg of clindamycin, into the vagina once daily at bedtime for 3 or 7 consecutive nights.

Cleocin vaginal cream is safe for pregnant people to use in the second and third trimesters. A pregnant person requires 7 days of treatment.

Pregnant people should not use clindamycin vaginal suppositories. Researchers have yet to confirm the safety of suppositories during pregnancy.

To use a suppository, a person can insert one suppository pill — which is equivalent to 100 mg of clindamycin — into the vagina once daily at bedtime for 3 consecutive nights.

People with a history of colitis should not use clindamycin creams or suppositories.

How to use lotions, gels, and solutions

Doctors prescribe clindamycin lotions, gels, and solutions to treat acne.

A person with acne can apply a thin layer of Cleocin T 1% lotion or clindamycin 1% solution to the affected area of skin twice per day.

A person can apply Clindagel 1% once daily to the affected area when acne appears.

Topical clindamycin can cause diarrhea. Anyone who has had colitis should avoid using this treatment.

How to take injectable clindamycin

If a person has a very serious infection and cannot take other antibiotics, they may receive injectable clindamycin at the hospital.

One of the most common side effects of many antibiotics is diarrhea. Sometimes, people experience severe diarrhea when taking clindamycin.

Clindamycin can alter the bacterial composition of the colon and cause an overgrowth of the Clostridium difficile bacterium. This bacterium produces toxins that can cause C. difficile-associated diarrhea (CDAD).

CDAD is a severe and life threatening infection. If a person develops CDAD while taking clindamycin, the doctor will immediately stop their treatment with the antibiotic.

Some other possible side effects of oral or injectable clindamycin include:

• abdominal pain
• irritation of the esophagus
• nausea and vomiting
• allergic skin reactions
• severe allergic reactions
• inflammation of the vagina
• fluid buildup under the skin
• impeded liver function
• impeded kidney function
• blood disorders
• disrupted function of the immune system
• arthritis

People using a clindamycin solution or lotion for acne may report skin-related side effects, including:

• dryness
• flushing or discoloration
• a burning or stinging sensation
• peeling
• itchiness
• oiliness

For example, when an individual uses Clindagel for acne, the most common side effects are itchiness and skin peeling.

People rarely experience diarrhea or colitis after using clindamycin topically. However, some people do report abdominal disturbances.

Clindamycin suppositories and vaginal creams may cause the same side effects as the oral or injectable forms.

Rarely, a person may develop colitis from using a vaginal clindamycin product.

Some other side effects of using clindamycin suppositories or vaginal creams include:

• vaginal fungal infections
• inflammation of the vagina and vulva
• disorders of the vagina or vulva
• vaginal pain

People with a history of pseudomembranous or ulcerative colitis should not take clindamycin. These two conditions cause severe inflammation of the lining of the intestine.

The side effects of taking clindamycin can worsen these two conditions.

Doctors should only prescribe clindamycin to people who have bacterial infections. This helps reduce the resistance that bacteria can develop to clindamycin.

Drug interactions may occur when using any form of clindamycin.

Historically, anesthesiologists have worried that clindamycin could delay the effectiveness of neuromuscular blocking agents through surgeries.

More recently, however, researchers have found that the drug may enhance the effect of a blocking agent.

When people take oral forms of clindamycin, the liver enzyme CYP3A4 breaks it down in the body. Stimulating the function of this enzyme can cause a decrease in levels of clindamycin. If something inhibits CYP3A4, clindamycin levels may increase in the blood.

Certain drugs can affect the functioning of CYP3A4. When a person is taking CYP3A4 stimulants along with clindamycin, doctors must follow up and make sure that the antibiotic is working.

If a person is taking an inhibitor of CYP3A4 with clindamycin, the increased levels of the antibiotic may cause side effects. Doctors should monitor any increase in adverse effects.

Clindamycin and lincomycin are the only members of the lincosamide family.

Lincomycin is only available as an injectable solution, and doctors prescribe it for serious infections.

Depending on the infection and the person’s history of allergies and side effects from antibiotics, a doctor may choose another class of antibiotics instead.

Clindamycin is an effective antibiotic for a variety of serious infections. People can also use clindamycin for treating acne.

However, there are many possible side effects of clindamycin. For this reason, doctors should weigh the benefits and risks before prescribing this antibiotic.

People with a history of colitis should avoid taking clindamycin because it could damage their health.

When serious side effects occur, they tend to affect people taking oral or injectable forms of clindamycin. However, they can also arise in people using topical forms.

Read the article in Spanish.

CLINDAMYCIN in the treatment of infectious and inflammatory diseases | Shchotizhnevik PHARMACY

Among all the pathology of ENT organs, infectious and inflammatory diseases occupy a leading position and, accordingly, they account for the majority of all cases of antibiotic therapy [2]. According to the American Academy of Otolaryngology and Head and Neck Surgery, sinusitis of bacterial etiology is the fifth most common disease requiring antibiotics [4]. Therefore, the study of the effectiveness of the use of individual antibiotics in the treatment of infectious and inflammatory diseases of the upper respiratory tract is relevant and of practical importance.

Clindamycin is an antibiotic of the lincosamide group, a semi-synthetic analogue of lincomycin (7-chlorodeoxy derivative of lincomycin), has a bacteriostatic effect due to inhibition of protein synthesis by ribosomes. High concentrations of the drug against highly sensitive microorganisms can have a bactericidal effect.

Clindamycin is resistant to gastric hydrochloric acid. After oral administration, it is rapidly absorbed from the digestive tract, its bioavailability is 90% and does not depend on food intake. When using the drug at a dose of 150 mg, the maximum concentration in blood serum (2. 5 μg / ml) is reached after about 45 minutes, after 3 hours it is 1.5 μg / ml, and after 6 hours – 0.7 μg / ml. Clindamycin is well distributed in most tissues and body fluids, with the exception of cerebrospinal fluid (poorly penetrates the blood-brain barrier). High concentrations of the drug are achieved in bronchopulmonary secretions, bone tissue, and bile. The half-life of clindamycin is 2-3 hours, 10% of the drug is excreted in the urine in the active form, 4% – in the feces, the rest – in the form of inactive metabolites. In renal failure, the pharmacokinetics of clindamycin does not change significantly. In patients with severely impaired liver function, the half-life of the drug may be significantly prolonged.

Most appropriate to prescribe clindamycin for infections caused by Streptococcus anaerobicus ( Peptostreptococcus ), Staphylococcus spp., Clostridium perfringens (in combination with benzylpenicillin), Corynebacterium diphtheria , as well as Bacteroides , intestinal and oropharyngeal anaerobes [1]. The drug is especially indicated for polymicrobial-mixed infections caused by bacteroids and other anaerobes of the oral cavity, the prevalence of which is observed in chronic tonsillitis, deep abscesses of the neck and due to infections of the oral cavity and teeth [3]. Clindamycin is more preferable than penicillins for the eradication of streptococci in tonsillopharyngitis, probably due to the presence of b-lactamase-producing polymicrobial microflora [5], against which unprotected penicillins are ineffective. Clindamycin is moderately active against some protozoa ( Toxoplasma gondii, Plasmodium falciparum) .

Oral administration of clindamycin may cause nausea, vomiting, diarrhea, esophagitis, pseudomembranous colitis (caused by Clostridium dificile) . Rarely, reversible leukopenia, thrombocytopenia, impaired renal function, a transient increase in the level of hepatic transaminases and bilirubin in the blood serum are noted, very rarely – allergic reactions.

We have studied the effectiveness of CLINDAMYCIN manufactured by Balkanfarma (Bulgaria) in the treatment of patients with chronic purulent sinusitis and chronic purulent otitis media in the acute phase, paratonsillitis, paratonsillar abscess.

The choice of ENT pathology, in the treatment of which the effectiveness of CLINDAMYCIN was studied, was due to the pharmacological characteristics of the drug, its antibacterial spectrum, as well as recommendations for use. The microbiological characteristics of individual infectious and inflammatory diseases of the upper respiratory tract were taken into account. For observation, 3 groups (50 people) of patients aged 18 to 65 years were selected.

Group 1 included 18 patients (8 women and 10 men) with chronic purulent sinusitis in the acute phase. The average age of patients was 43.5 ± 7.2 years. Diagnosis was carried out on the basis of anamnesis data, otorhinolaryngological examination, radiography and ultrasound of the paranasal sinuses. The effectiveness of treatment was monitored based on patient complaints, rhinoscopy data, ultrasound of the paranasal sinuses, as well as the results of a general clinical blood test. Treatment of patients of the 1st group lasted for 7–14 days. CLINDAMYCIN was administered orally at a dose of 150-300 mg 4 times a day. The maxillary sinuses were punctured, followed by rinsing with a solution of nitrofural, analgesics, antihistamines (mebhydrolin, loratadine), decongestants for local and systemic use.

Group 2 included 11 patients (6 men and 5 women) with chronic suppurative otitis media in the acute phase. The average age of patients was 54 ± 3.8 years. Treatment effectiveness was monitored based on subjective data, as well as the results of an otorhinolaryngological examination and audiometry, and a general clinical blood test. Antibiotic therapy for patients of the 2nd group was also carried out for 7–14 days. CLINDAMYCIN at a dose of 150-300 mg was administered orally 4 times a day. Additionally, drops were prescribed in the external auditory canal (betamethasone + gentamicin) and vasoconstrictors in the form of nasal drops (naphazoline), antihistamines.

Group 3 included 12 patients (7 men and 5 women) with paratonsillitis and 10 (6 men and 4 women) with peritonsillar abscess. The average age of patients in group 3 was 32 ± 5.6 years. Diagnosis was made on the basis of anamnesis and oropharyngoscopy data. CLINDAMYCIN was prescribed at a dose of 150-300 mg 4 times a day for 5-14 days. Patients with paratonsillitis or paratonsillar abscess were additionally prescribed analgesics (metamisole sodium), rinsing with a solution of nitrofural (1:5000), and the abscess was drained.

In all patients before and after treatment, a microbiological examination of the smear / discharge was performed, the sensitivity of the isolated microflora to CLINDAMYCIN was determined.

The treatment was considered effective in the complete disappearance or significant reduction in the severity of the clinical symptoms of the disease.

The safety of therapy was assessed by the incidence of side effects during the entire observation period.

Microbiological examination revealed a rather high sensitivity of the isolated microflora to CLINDAMYCIN — sensitive strains accounted for 83.3% of the total isolated bacterial microflora. Fungal flora was detected in two patients with chronic purulent sinusitis in the acute phase ( Candida albicans ) and one patient with chronic suppurative otitis media in the acute phase ( Aspergillius niger ).

In tab. 1 shows the results of a study of the sensitivity of the isolated microflora to CLINDAMYCIN.

Table 1

Microflora sensitivity to CLINDAMYCIN

2 summarizes the results of evaluation of the therapeutic efficacy of CLINDAMYCIN.

Table 2

Evaluation of the therapeutic efficacy of CLINDAMYCIN

Recovery and improvement was achieved in 44 (88%) patients out of 50. The highest efficiency of CLINDAMYCIN was observed in patients of the 3rd group: recovery – in 90% with paratonsillitis and 90.9% with paratonsillar abscess. Sufficiently high efficacy of CLINDAMYCIN treatment was noted in chronic sinusitis – clinical remission and improvement were achieved in 88.9% of cases.

If treatment with CLINDAMYCIN was ineffective (according to the results of microbiological examination obtained on the 3-5th day of treatment), it was replaced with another drug. Thus, patients with exacerbation of chronic purulent sinusitis and exacerbation of chronic purulent otitis media, in whom fungal flora was isolated, were prescribed fluconazole orally at a dose of 50 mg 1 time per day for 5–14 days, and a patient with paratonsillar abscess, in whom enterococcus insensitive to CLINDAMYCIN – vancomycin intravenously at a dose of 1 g 2 times a day for 5 days.

When comparing the results of a general clinical blood test before and after complex treatment with the use of CLINDAMYCIN, a significant decrease in the number of leukocytes in peripheral blood and ESR was revealed. The development of leukopenia and thrombocytopenia was not observed.

Treatment with clindamycin caused side effects in 3 cases. One patient with chronic sinusitis and a history of intestinal dysbacteriosis experienced nausea, abdominal pain, and diarrhea on the 4th day of treatment. In this regard, CLINDAMYCIN was canceled, no other antibiotic was prescribed. One patient with paratonsillitis complained of slight nausea and diarrhea on the 5th day of treatment, but CLINDAMYCIN was not discontinued. By the 6th day of treatment, a patient with sinusitis developed a rash similar to urticaria on the skin of the upper limbs and trunk. CLINDAMYCIN was not discontinued, loratadine was administered orally at a dose of 10 mg per day.

The results of the study indicate that oral administration of CLINDAMYCIN at a dose of 150-300 mg 4 times a day for 5-14 days is highly effective in the treatment of patients with paratonsillitis, paratonsillar abscess, as well as chronic purulent sinusitis, purulent otitis media in the acute phase .

A.S. Chemerkin, I.S. Zaritskaya,
N.N. Mogilevskaya
Institute of Otolaryngology
im. A.I. Kolomiychenko Academy of Medical Sciences of Ukraine

The article was provided by the representative office of Balkanpharma in Ukraine

Office address:
01034, Kyiv, st. Yaroslavov Val, 38

Niotite ear drops – instructions for use for otitis media and ear pain

Contents 0483

Contents

What is otitis and how does it manifest

Otitis is an inflammatory process in various parts of the ear. It is classified into external, middle and internal according to the three parts of the organ of hearing. Otitis externa develops during a pathological process in the auricle and auditory canal, up to the tympanic membrane. Otitis media is an inflammation in the tympanic cavity, in which the auditory ossicles are located. Otitis media is an inflammatory process that affects the internal system of canals that are located behind the middle ear cavity.

Otitis externa is more often caused by mechanical, chemical injuries of the ear, through which the infection enters. Its symptoms: throbbing pain, radiating to the neck, jaw. Increases with jaw movement. Outwardly, redness of the skin of the auricle or ear canal is noted. If there is an abscess, then when it breaks, the ear canal can fill with pus, due to which hearing can decrease.

Otitis media can be caused by many pathogens: bacteria, viruses, fungi. It often develops against the background of SARS, influenza. The symptomatology of the disease is different, depending on the pathogen, the severity of the process, the condition of the eardrum. The most common complaint is shooting pain. If there is pus in the cavity, a feeling of fullness is possible. When pus breaks through the eardrum, the pain subsides. If the pus erupted towards the outer ear, note its outflow from the ear.

Otitis media or labyrinthitis – often a complication of the middle ear, with a breakthrough of pus towards the inner ear. The disease is manifested by severe dizziness, which can be combined with nausea and vomiting. Bacteria and viruses can be another reason. Of the diseases, otitis media of the inner ear can provoke meningitis.

Indications for the appointment of ear drops

Drops for inflammation in the ear are prescribed in the following cases:

• otitis media;
• otitis externa;
• acute catarrh of the ear;
• infectious inflammations;
• otitis after pressure drops;
• inflammation after prolonged contact with water;
• pain;
• sulfur plugs.

Anti-inflammatory otics are used for symptomatic treatment. They have a local effect, reducing swelling, but do not destroy the infection.

With internal otitis and eustachitis, drops with anti-inflammatory action are not effective.

This is due to the removal of the focus of inflammation from the external passage. With perichondritis, antibiotics and antiseptics will better cope with the disease.

What are the advantages of drops in otitis media

Means in the form of drops have a local effect, that is, their active components practically do not penetrate into the general blood flow, the percentage of their entry into the systemic circulation depends on the active component. If the drug does not act only in the ear cavity, then the likelihood of developing systemic side effects is extremely small. When using drugs for the treatment of otitis media, which must be taken orally, the components enter the general bloodstream, decompose in the liver.

After instillation, the active substances are immediately absorbed into the ear cavity, showing their therapeutic effect. Drugs for oral administration must first penetrate the mucous membranes and enter the bloodstream, and then act on the focus of inflammation, and this takes time. In addition, the effectiveness of such agents can reduce inflammatory processes in the mucous membrane, due to which the absorption of components may be difficult.

Almost all bottles are equipped with special droppers, which makes them very convenient to use. Most of the drugs in the form of drops are dispensed from pharmacies without a doctor’s prescription. Economic use. Drops are used in small dosages, on average 2-3 per instillation, so one bottle is enough for a long time.

An important plus of drops is the minimum list of side effects, contraindications, which is associated with their local application.

How to properly instill drops in the ears

Wash hands thoroughly with soap and water before instillation. Before instillation, it is necessary to clean the ear cavity if it contains an excess amount of sulfur or liquid discharge. If the ear is not cleaned first, then sulfur or liquid will make it difficult for drops to penetrate into the ear cavity, and their effectiveness decreases accordingly. For cleaning, it is recommended to use children’s ear sticks equipped with a limiter (wide base, thin tip).

Ordinary sticks are intended only for cleaning the skin of the auricle, if they are used to clean the ear canal, earwax can push inward, which can lead to the formation of an ear plug, hearing loss, and inflammation. If sulfur is located deep, it can be removed by dropping a few drops of hydrogen peroxide. It will soften it and bring it out of the cavity. You can not drip peroxide, but moisten a cotton turunda with it and insert it into your ear for 5 minutes.

After instillation, crackling is heard in the ear, which is not a cause for concern – this is how peroxide works.

After 5 minutes, remove the softened wax with a stick or put it on the sore ear so that the peroxide and the wax flow out of the ear. It is forbidden to perform such a procedure if the eardrum is damaged.

See also: Otosclerosis: what it is, what are the signs of the disease and treatment tactics Putting drugs on heating devices is prohibited, most chemicals are destroyed, lose their medicinal properties. To drip drops you need:

• lie down on your healthy side;
• pull the ear shell slightly to the side and up so that the drops penetrate deeper into the ear canal;
• add the required number of drops;
• close the ear canal with dry cotton so that the preparation warms up and does not leak out;
• lie down on your healthy side for about 10 minutes.

If multiple ear drops are prescribed, the minimum interval between drops is 20 minutes.

Niotite Ear Drops Instructions for Use

In case of inflammation of the outer part of the ear or otitis media, first of all it is necessary to undergo an examination by an ENT doctor. Only after his appointment of Niotit ear drops, purchase the drug at a pharmacy. Specify the allowable dosage in advance.

Before injecting medicine into the diseased ear , replace the bottle cap with a plastic one. It combines the drip tip and rubber papilla that come with the product.

After this clean the ear with 3% hydrogen peroxide.

To do this, lay the patient on one side and inject five drops of into the ears. Then the turunda should be placed in the ear canal for fifteen minutes. After the appointed time, wipe the ear canal and outer ear with a clean cotton pad. After completion of these procedures, the use of the drug is allowed.

Immediately before the introduction of “Niotite” into the ears , the bottle of liquid must be warmed up to body temperature . To do this, rub the bottle in your hands or dip it in warm water for a few minutes.

Tilt the patient’s head to the opposite side and carefully insert the drops down the back of the ear canal. To improve the effect, pull the earlobe down. Thus, you will improve the penetration of the agent into the focus of inflammation.

After the insertion into the ears, massage the ear and the tragus. To do this, warm your palms by rubbing them together. Then gently touch the outer ear and move your palms in a clockwise direction. After that, press several times on the tragus.

Repeat this operation for five minutes. After that, rinse the ear with warm water and carefully wipe the outer ear and ear canal with a cotton pad. Keep water out of the ear. It is a favorable environment for the development of bacteria and infections. Product name

Niotite-DF

International non-proprietary name

No

Dosage form

Ear drops, 10 ml 3

Composition

10 ml solution contains

active ingredients: chloramphenicol 0.1 g ,

lidocaine hydrochloride 0. 1 g,

excipients: boric acid 0.1 g, ethyl alcohol 70%.

Description

Clear, colorless or slightly yellowish liquid.

Pharmacotherapeutic group

Other preparations for the treatment of otological diseases.

ATC code S02DA30

Pharmacological properties

Pharmacokinetics

When applied topically as ear drops, systemic absorption is low.

Pharmacodynamics

Niotit-DF is a combined topical preparation. It has an antibacterial and local anesthetic effect. Chloramphenicol is a broad-spectrum bacteriostatic antibiotic. Violates the process of protein synthesis in a microbial cell (having good lipophilicity, it penetrates through the bacterial cell membrane and binds back to the 5OS subunit of bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms (Staphylococcus spp., Streptococcus spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Serratia spp., Proteus spp., etc.), causing the development of infectious and inflammatory diseases of the external and middle ear resistant to penicillin, tetracyclines, sulfonamides.

Lidocaine hydrochloride, which has a local anesthetic effect, relieves the sharp pain that accompanies most ear diseases. The combination of antibacterial and local anesthetic agents in an alcoholic solution enhances the therapeutic effect of the drug.

Indications for use

Dosage and administration

Before using Niotit-DF, the external auditory canal should be cleaned. To do this, a small piece of sterile cotton wool is wound onto a probe or onto a sulfur-free end of a match. At the same time, at the very end of the probe or match, cotton wool must be fluffed. The patient is pulled back and up the auricle to align the external auditory canal. A probe or a match with cotton wool is slowly and carefully inserted deep into the ear canal to the eardrum (depth 2.0 cm). By gently rotating the probe or match (clockwise) along the walls of the ear canal, pathological content and retrieved back. Change the cotton wool and repeat the toilet until the cotton wool and the external auditory canal are dry and clean.

Then, the drug is instilled along the back upper wall of the ear canal, while tilting the patient’s head in the opposite direction. After instillation, they press the tragus several times with a cotton ball, as if massaging it and the ear. The drug is kept in the ear for 10-15 minutes, then, tilting the head in the opposite direction, it is poured out. The external auditory canal is dried and covered with a sterile cotton swab.

See also: Albucid in the ear – instructions for proper use

Drops should be warm, at body temperature (so as not to irritate the labyrinth). To do this, before instillation, the vial with the drug is placed for several minutes in warm water (35-36 ° C).

If Niotit-DF is used in a vial complete with a plastic dropper, the vial cap must be replaced with a dropper before use.

Instilled into the external auditory canal 3-4 times a day:

– children over 3 years old, 3-5 drops each

– adults and children over 14 years old, 4-5 drops each

Course of treatment: for children – 2-5 days; for adults – 5-10 days.

It is also possible to lay cotton turunda moistened with the preparation. A dense flagellum 2-2.5 cm long is twisted from a piece of sterile cotton. It is moistened with a few drops of a warm preparation and introduced into the ear canal with rotational movements, after pulling the auricle back and up. The tip of the turunda must be left outside so that it can be easily removed. Humidity of the turunda is maintained by instilling warm medicine every 3-5 hours. Turunda is changed once a day. The duration of the drug use with the help of turunda is determined by the doctor.

Side effects

Rarely

– irritation of the skin and mucous membranes

– local allergic reactions in the form of rash, itching, redness and swelling of tissues

Contraindications 9 0407

– perforation of the tympanic membrane of an infectious or traumatic nature

– increased individual sensitivity to any of the components of the drug

– pregnancy and lactation

– children under 3 years of age

– viral and fungal infections of the ears

– eczema of the external auditory canal

– depression of bone marrow hematopoiesis

– acute intermittent porphyria

– deficiency of glucose-6-phosphate dehydrogenase 900 03

Drug interactions

Not recommended for concomitant use ear medications.

When used simultaneously with erythromycin, clindamycin, lincomycin, mutual weakening of the action is noted due to the fact that chloramphenicol can displace these drugs from the bound state or prevent them from binding to the 50S subunit of bacterial ribosomes.

Reduces the antibacterial effect of aminoglycosides, penicillins, polymyxin B, tetracyclines, cephalosporins, erythromycin. It is also incompatible with ascorbic acid, hydrocortisone, B vitamins.

Systematic monitoring of the picture of peripheral blood is necessary during the treatment.

Use with caution in patients who have previously received cytotoxic drugs or radiation therapy.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery

Does not affect.

Overdose

No overdose has been observed with topical application.

Symptoms in case of accidental ingestion: nausea, vomiting, diarrhoea, headache, skin rashes, confusion, decrease in body temperature.

Treatment – symptomatic; it is necessary to ensure sufficient fluid intake in the body.

Release form and packaging

10 ml of the drug in glass bottles with a plastic screw cap that combines a glass dropper and a rubber nipple, or in glass bottles sealed with a plastic screw cap, complete with a plastic dropper. One bottle, together with instructions for medical use in the state and Russian languages, is placed in a cardboard pack or one bottle, together with a plastic dropper and instructions for medical use in the state and Russian languages, is placed in a cardboard pack.

Storage conditions

Store in a place protected from light, at a temperature not exceeding 20 0С.

Keep out of reach of children!

Shelf life

3 years

After opening the vial, the drug is valid for 28 days.

Do not use after the expiry date which is stated on the packaging.

Terms of dispensing from pharmacies

Without a prescription

About the drug, its active ingredients and side effects

Ear diseases cause severe inconvenience, excruciating pain, and complete or partial hearing loss. To get rid of these symptoms, the patient must be given comprehensive treatment. In this case, the patient is prescribed ear drops “Niotit” , the instructions for use of which will be discussed below.

This agent has a local effect in case of inflammation of otitis media, as well as in otitis externa.

It is important to know that these drops are prohibited in case of perforation of the eardrum and with purulent discharge.

“Niotite” is considered to be an effective drug , available in the form of ten milliliter ear drops.

The product contains active ingredients and auxiliary elements:

1. Chloramphenicol.
2. Lidocaine.
3. Boric acid.
4. Ethyl alcohol.

Due to the fact that the drug contains analgesics and anesthetics, the drops eliminate the focus of inflammation in a short time. Thanks to alcohol, the remedy relieves pain, and also significantly improves the overall well-being of the patient.

When purchasing the drug, please note that the color of the drug should be either transparent or slightly yellow . In case of painting in other colors, do not purchase the drug, as there is a possibility of a fake.

Ear drops “Niotit” is considered a combined remedy with an antibacterial effect.

In addition, the agent anesthetizes the affected area immediately after injection into the ears.

Chloramphenicol , which is part of the drug, is considered an antibiotic with a wide spectrum of action.

Read also: How to drip Otipax?

It penetrates into infected cells and binds tightly to them, destroying the infection from the inside. As a result, the virus is quickly eliminated from the body.

The second active ingredient in the formulation is lidocaine. It relieves the shooting pains that accompany otitis externa or otitis media. Due to the fact that the drug contains acid and alcohol, the effect of lidocaine is enhanced and has a therapeutic effect.

Specialists prescribe these drops for two types of otitis media , with which it copes equally well:

1. In the case of external otitis, but in the case of a whole eardrum.
2. For otitis media without various discharges.

Remember that self-treatment of ear infections is strictly prohibited. Therefore, before buying “Niotit” consult with your doctor. After purchasing the remedy, carefully study the side effects of the medication.

The main unpleasant consequences of its use include the following points:

1. Swelling of the mucous membrane in the ear canal.
2. Severe irritation of the skin of the ear.
3. In some cases, there is itching, burning sensation, and redness of the external ear.

Separately, it is noted that the instillation of “Niotite” is prohibited if there are holes on the eardrum.

Do not use medication with special sensitivity to the components that make up the drug.

During pregnancy, as well as when breastfeeding a baby, instillation of the drug is also prohibited .

In case of illness in children, the use of drops is allowed only from the age of three.

In addition to the listed contraindications, there are several more prohibitions:

1. Do not instill drops in case of viral inflammation in the ears.
2. If there is a white coating or fungus.
3. In case of eczema on the outside of the ear.
4. For acute inflammations.

During the treatment of otitis, it is important to take complex therapy, however, instillation of Niotit drops simultaneously with other drops is not desirable. Since most topical preparations contain erythromycins, clindamycins and lincomycins.

The active substance of the described drops is chloramphenicol, which can displace the listed medicines. In this regard, an overdose and deterioration of the patient’s condition may occur.

In addition, in the process of treating otitis media , it is important to strictly follow the dosage of prescribed by the attending physician.

If the dosage of is increased independently, adverse reactions may occur , as well as severe dizziness, fatigue, drowsiness or nervous excitement.

In special cases, the appearance of tachycardia and hypertension is noted.

In more serious cases, convulsions, memory loss, confusion, nausea, vomiting, severe pain in the ears and head occur.

For the same reason, doctors do not recommend the use of “Niotit” for prevention.

It is important to know that after a course of treatment with this drug, the state of the peripheral blood should be checked.

In case of accidental ingestion of , nausea, vomiting, shooting pains in the head, rashes on the skin, a strong decrease in body temperature are noted. Therefore, store the drug in a dark place out of the reach of children.

If you did not follow and the child still drank the drops, it is necessary to cleanse the body. In addition, the child should drink plenty of water.

Contraindications

– perforation of the tympanic membrane of an infectious or traumatic nature

– increased individual sensitivity to any of the components of the drug

– pregnancy and lactation

– children under 3 years of age

– viral or fungal diseases of the ear

– eczema of the external auditory canal

– oppression of bone marrow hematopoiesis

– acute intermittent porphyria

– deficiency of glucose-6-phosphate dehydrogenase

Medication dosing

9 0479 In each case of ear inflammation, the dosage is selected by the attending physician. Usually, for otitis externa, is injected into the diseased ear three or four drops three times a day. This dosage is suitable for the treatment of from 14 years of age.

Proper insertion of drops into the ears.

In the case of treatment of children older than three years, it is recommended to instill two drops twice a day.

The course of treatment in this case is from two to five days. For adults, therapy is increased to one week.

Overdose

No overdose has been observed with topical application.

Symptoms in case of accidental ingestion: nausea, vomiting, diarrhoea, headache, skin rashes, confusion, decrease in body temperature.

Treatment: symptomatic, it is necessary to ensure sufficient fluid intake in the body.

Storage conditions

Pharmacy dispensing conditions

Without a prescription

Release form

Niotit-DF – ear drops. 10 ml of the drug in glass bottles with a plastic screw cap that combines a glass dropper and a rubber nipple, or in glass bottles sealed with a plastic screw cap, complete with a plastic dropper.

Conclusion

Otitis is a dangerous inflammation that has a lot of unpleasant consequences. Therefore, at the first sign of an ear disease, you should consult a qualified doctor.