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Is it ok to take two benadryl: BENADRYL® Dosing Guide: Adult & Children’s Diphenhydramine Dosage

Getting High on Benadryl: How Much Is Safe?

Benadryl is a brand name over-the-counter antihistamine medication. Histamine is a substance produced by the body in response to the presence of allergens like pollen, animal hair, or dust. Histamine release underlies certain symptoms like sneezing, itchy eyes, scratchy feelings in the nose or throat, runny nose, and difficulty breathing. Antihistamines like Benadryl combat the actions of histamine. Some people may also take Benadryl to reduce similar symptoms when they have a cold. Diphenhydramine is the main ingredient in this drug, and the substance can be found in other over-the-counter medications, too.1

Although Benadryl is sold without a prescription, the drug can cause drowsiness and sedation. Misuse of the medication may occur because people do not properly read the directions, mix it with alcohol or other intoxicants, or take too much of it at once. Any form of misuse can be dangerous and may result in severe side effects or an overdose. 1

Just like with a prescription drug, it is important to follow the instructions on the package and only take Benadryl in recommended doses for a short period of time.

What Is Benadryl? How Is It Taken Safely?

Benadryl was the first antihistamine to receive approval from the Food and Drug Administration (FDA). The brand name was acquired by Johnson & Johnson in 2007 and the medication remains a widely-used treatment for allergies and mild cold symptoms.1

Since the medication has been available for several decades, safe dosage and elimination time are well understood. Benadryl is available in a variety of formulations, including tablets, liquid gels, and chewables. The standard dose of diphenhydramine in brand name Benadryl is 25 mg per dose for adults and 12.5 mg per dose in children’s formulas. For the average healthy adult, elimination half-life ranges from 6.7 to 11.7 hours.So between 6 to 12 hours after taking Benadryl, half the drug will be eliminated from the body. Within two days, the drug will be completely gone from the body.

Several factors impact how quickly Benadryl is metabolized, including: 3

  • AgeAdults over 65 years old and children younger than 12 years old metabolize diphenhydramine more slowly, so lower doses less often are safer.3
  • Liver problemsSince the active ingredient in Benadryl is processed through the liver, anyone with decreased hepatic function will have difficulty safely consuming this drug.
  • Kidney problemsThe kidneys help to process toxins by passing them out through the bladder. People who have decreased renal function may have a tough time metabolizing Benadryl. Urinary pH can also impact how the body processes diphenhydramine.
  • HydrationPeople who do not drink sufficient water may struggle to eliminate diphenhydramine from their system.
  • Low vs. high doseEven healthy adults who take more than the recommended dose of Benadryl will experience consequences, such as taking longer to metabolize the drug. Taking the recommended dose of Benadryl for longer than recommended may also lead to tolerance as the drug builds up in the body, and that also might increase the medication’s elimination time.
  • Other medicationsTaking prescription drugs, or other over the counter drugs, along with Benadryl may change how the body metabolizes all the substances together.
  • Body weight/massDifferent body types process different amounts of medication at different rates. This is true for prescription drugs, recreational substances like alcohol, and over the counter drugs like Benadryl.

Although Benadryl is sold over the counter without a prescription, the active ingredient is potent and has an impact on the body. In addition to eliminating symptoms of allergies or a cold, it also interacts with other organ systems.

Even when taken as directed, Benadryl can cause side effects which include: 4

  • Drowsiness or sleepiness.
  • Dry mouth.
  • Dryness in the nose or throat.
  • Dizziness.
  • Nausea or stomach upset.
  • Headaches.
  • Jitteriness or restlessness.
  • Tightness in the chest.
  • Muscle weakness.
  • Loss of appetite.
  • Constipation.

When the recommended amount is consumed, effects peak after about two hours. Within four hours, most effects of the medication wear off. There are still metabolites from diphenhydramine’s breakdown in the body, so taking another dose of Benadryl before the full effects wear off may be dangerous.5

Additionally, some people take more than the recommended amount because they want to get high. Benadryl produces mild sedative effects, and in larger amounts, that can feel like intoxication.

However, taking more than 25 mg can be extremely dangerous and is more likely to cause harm than produce any euphoria. 5

Benadryl Overdose

Too much Benadryl can lead to an overdose and taking the drug with other potent substances can increase the risk of overdose.

For example, taking other antihistamines that contain diphenhydramine can lead to an overdose. Substances like alcohol or benzodiazepines (e.g., Valium, Xanax, Klonopin, etc.) may dangerously increase Benadryl’s sedative effects.

Muscle relaxants, sedative-hypnotic sleep medications like Ambien, tranquilizers, opioids, and other prescription drugs that are central nervous system (CNS) depressants can also adversely interact with Benadryl. In addition, some types of antidepressants called monoamine oxidase inhibitors (MAOIs) do not mix with antihistamines like Benadryl.3

Symptoms of a Benadryl overdose include: 6

  • Enlarged pupils.
  • Very dry eyes.
  • Blurry vision.
  • Ringing in the ears (tinnitus).
  • Low blood pressure.
  • Rapid heart rate.
  • Agitation, rapid mood swings, or restlessness.
  • Confusion.
  • Seizures.
  • Delirium.
  • Intense, sudden depression.
  • Extreme drowsiness.
  • Passing out or falling asleep.
  • Nervousness or paranoia.
  • Physical tremors.
  • Unsteady gait, loss of balance, or inability to walk.
  • Dry, red skin.
  • Nausea or vomiting.
  • Inability to urinate.

Attempting to Get High on Benadryl Can Be Extremely Dangerous

Benadryl is not effective as an intoxicant.Taking more than the recommended dose is more likely to lead to an overdose and uncomfortable side effects rather than euphoria. More than 500 mg, which is more than 40 times the recommended dose, may lead to a state of delirium, hallucinations, and other overdose symptoms. Anecdotal evidence about diphenhydramine highs indicates that the effects are more often uncomfortable and unsettling instead of enjoyable.

Attempts at getting high on Benadryl may be indicative of larger issues with addiction or substance abuse. Because Benadryl is easy to acquire, it may be the first drug abused by an adolescent, or it could be a drug abused after struggling with other substances. Regardless, it is important to get help ending substance abuse.

There are many risks in taking Benadryl long term, or mixing it with another drug or medication. If you have been abusing the prescribed dosage for Benadryl, it’s important to be informed about other potential signs that could lead to addiction.

If you or someone you love is struggling with substance abuse issues and are unsure of where to turn, call us today at . River Oaks, one of American Addiction Centers’ Florida rehab centers, is ready to help you overcome addiction and find long-term recovery. Call us today at to learn more about addiction treatment near you.

You aren’t alone. You deserve to get help.

We are here to help you get sober and learn how to stay that way. Retreat to the sunny climate near Tampa, Florida for a stay at the gold standard of treatment facilities. At River Oaks, we offer customized care plans to help you on your recovery journey at our beautiful Hillsborough County campus.

Can I Take Two Different Allergy Pills in One Day? (2023) | Wyndly

Learning Center / Learn / Allergy Treatments /

Can I take 2 allergy pills a day?

It is important to take allergy pills and antihistamines as directed. If your allergy medications do not provide enough relief from your symptoms, do not take additional doses. Instead, reach out to your doctor to find a more effective allergy treatment plan.

When you have allergies, you might feel tempted to take an extra dose of your antihistamine if you aren’t experiencing any allergy relief after taking your first pill. However, this can be dangerous, especially if you’ve never been to an allergist or allergy doctor to get a specific allergy treatment plan.

Mixing similar allergy pills or increasing the dose you take can result in unwanted side effects that can be very serious. Be very cautious about the allergy medications you combine and talk to a doctor when you have questions about treating your allergies.

Schedule a consultation with one of our allergy doctors to get a more effective allergy treatment plan, or continue reading to learn about how to safely treat your allergies.

What Are the Most Common Allergy Symptoms?

More than 50 million people in the US have allergy symptoms. Everyone experiences their allergy symptoms slightly differently depending on the severity of their allergies and their medical history. Some common symptoms you could experience include:

  • Runny nose
  • Watery eyes
  • Ear pain
  • Nasal congestion
  • Coughing
  • Sneezing
  • Fatigue

Having allergies can severely impact someone’s health and quality of life. If you are constantly being exposed to the allergens you are allergic to, you might suffer a lot from your never-ending symptoms. In particular, if you have pollen allergies and are frequently outside, it can be hard to avoid exposure to your allergens.

When you’re dealing with allergy symptoms, over-the-counter (OTC) antihistamines, nasal sprays, and eye drops can initially feel like a lifesaver. But these medications frequently don’t provide enough relief from your allergy symptoms, especially if your allergies are more severe.

However, this doesn’t mean you should try to combine similar types of medicines or change your allergy medication prescription without consulting with your doctor. Make sure that you’re following the specific guidelines of your medical treatment because altering the doses could have negative effects on your health.

How Do Antihistamines Work?

OTC antihistamines work by blocking the release of histamine, a chemical your immune system produces when you are exposed to your allergy triggers. The release of histamine can result in many different allergy symptoms as an attempt to get the allergens out of your body.

Difference Between First-Generation and Second-Generation Antihistamines

There are two different generations of antihistamines. First-generation antihistamines, like diphenhydramine (Benadryl), cause drowsiness and fatigue. Second-generation, non-sedating antihistamines are newer antihistamines that are also effective but do not cause drowsiness unless you take very high doses. Second-generation antihistamines include loratadine (Claritin), cetirizine (Zyrtec), and fexofenadine (Allegra).

How Often Can Over-The-Counter Allergy Medications Be Taken?

Most OTC allergy medications are only meant to be taken once a day. However, some antihistamines can be taken multiple times a day depending on the recommended dosage on the packaging or as instructed by a doctor. It is important to take OTC allergy meds as directed to avoid harmful side effects.  

For example, while Claritin 24-hour and Allegra 24-hour tablets are only taken once every 24 hours, Claritin 12-hour and Allegra 12-hour tablets are typically taken once every 12 hours. Benadryl is usually taken once every 4-6 hours or as directed by a doctor. 

How Can You Safely Take Allergy Meds?

Antihistamines have been around for decades and are effective for short-term allergy relief. However, they must be taken according to the recommended dosage or the directions of your doctor.

Even if you’re severely suffering from allergies, with incredibly watery eyes or a scratchy throat, it’s not recommended to take more than the daily dosage as there can be side effects that occur. If your OTC antihistamine isn’t effective in treating your allergy symptoms, you can talk to a doctor to find a more effective treatment plan.

Is Mixing Allergy Meds Safe?

You can safely mix different types of allergy medications, like Flonase, a nasal spray, and Claritin, an antihistamine. In fact, it’s often recommended by doctors. Choosing two allergy treatments that you take through different routes, like taking a pill and using eye drops, can decrease the risk of interactions between the medications.

While antihistamine pills can and are frequently combined with oral decongestants, like pseudoephedrine (Sudafed), they can have some adverse side effects. This can cause headaches, lightheadedness, a dry nose, and more. It is important that you talk with your doctor if you experience side effects from your medications.

It is not recommended to combine steroid nasal sprays with each other and it is not safe to mix different types of antihistamine allergy pills. If your allergy treatments are not as effective as you need, consult your doctor to adjust the dosage or your medication.

What Are Symptoms of Antihistamine Overdose?

If you experience dry mouth, agitation, dizziness, nausea, a racing heartbeat, or poor balance/coordination, please seek medical attention immediately. An antihistamine overdose can have severe side effects and complications. Symptoms of an antihistamine overdose include having elevated blood pressure, a rapid heart rate, hallucinations, seizures, and more.

Additionally, it is possible to take too much of a first-generation (sedative) antihistamine and if this is the case and you’re feeling extremely drowsy or fatigued, also seek medical attention.

Take Our Allergy Assessment

If you want long-term relief from your allergies, sublingual immunotherapy might be the best option for you. Instead of temporarily masking your symptoms, sublingual immunotherapy retrains your immune system to stop reacting to your allergies. At Wyndly, our allergy doctors will create a personalized treatment plan for your allergies to get you living allergy-free.

Take our brief online assessment today to see how Wyndly can help you!

Related Articles

How Do Antihistamines Help Your Allergy Symptoms?

Is It Safe to Use Antihistamines Every Day?

Are Antihistamines Safe for Improving Allergy Symptoms?

What Are the Best Types of Antihistamines and How Do They Work?

What Is the Best OTC Antihistamine for Your Allergies?

Why Are Antihistamines Not Working for Me?

Can Antihistamines Make You Gain Weight?


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How long after Tylenol can Benadryl be given (and why)? –

Last updated: December 2, 2022 / author
Sandeep Bhandari

/ Fact verified / 4 minutes

Exact answer: no interaction found (consult your doctor).

Medicine is the science of treating, managing, preventing and stopping disease. Tylenol is the trade name for paracetamol, also known as acetaminophen. This is a medicine that is used to treat fever and mild to moderate pain.


Test your knowledge of health-related topics

1 / 10

What is the best way to maintain a healthy weight?

Calorie counting

Eat smaller meals

Regular exercise

All of the above

2 / 10

Physical health is…

How slim and how healthy your body is.

The pH in your body that is related to your emotions

How focused are you on other people’s bodies.

None of the above

3 / 10

Which vitamin helps strengthen bones and teeth?

Vitamin A

Vitamin C

Vitamin D supplements

Vitamin E

4 / 10

Which of the following is NOT a symptom of depression?


Loss of interest in activities


Increased appetite

5 / 10

Which of the following is NOT a symptom of a cold?

Sore throat

Runny nose



6 / 10

Products containing sugar and starch. Most of your energy comes from such food. Products with natural sugar or starch are the best source of such food.





7 / 10

What is the role of carbohydrates in our diet?

Provide energy

Build muscle

Help digestion

Regulate body temperature

8 / 10

White blood cells that attack pathogens are called ______________.




None of these

9 / 10

Many children with asthma experience more severe reactions when they breathe ___________________.

Secondhand smoke

Carbon dioxide



10 / 10

What type of arthritis is most common?

Rheumatoid arthritis


Psoriatic arthritis


your account



relieve pain in acute mild migraine. It is also effective for post-operative pain. Benadryl is the trade name for diphenhydramine. It is an antihistamine drug that is mainly used to treat allergies. This medicine can also be used to treat symptoms of colds, coughs, and nausea. The maximum effect of Benadryl is usually around two hours and can last up to seven hours.

How long after Tylenol can I give Benadryl?

Age group Tylenol Doses
Adults (weight 50 kg) less than 4000 mg
Children (age 12 years) Less than 3250 mg

Between Tylenol and no interactions have been found with Benadryl, so they can be taken together or as directed by a doctor or pharmacist. Tylenol can be used as directed on the label or as directed by your healthcare professional. Tylenol should not be used with a medicine containing acetaminophen. This can lead to a fatal overdose.

Tylenol dosages vary for different age groups. People with a body weight of at least 50 kg should not take 1000 mg at a time. It is recommended not to take 4000 mg within 24 hours. Children under 12 years of age should not take more than 5 doses of the above drug in 24 hours.

Tylenol is manufactured by the McNeil Consumer Products Company. It is a subsidiary of Johnson and Johnson. Mr. McNeil, who died at the age of 94, created Tylenol in 1955. Benadryl is recommended to be taken as directed or as directed by your doctor. Adults should not take more than 300mg of Benadryl per day.

Less than 150 mg per day is recommended for children. Benadryl Spray should not be used more than 5 times a day. This condition applies to both adults and children. Benadryl dosages depend on several factors such as the type of condition, age, and the form of medication you are taking. The body’s response to Benadryl may decrease over time.

Benadryl was invented by the American chemist and professor George Rivechel. It began to be used commercially in 1946. It has been approved by the FDA (Food and Drug Administration).

Why can I take Benadryl for so long after Tylenol?

The side effects of Tylenol and Benadryl can be treated with each other and Tylenol and Benadryl do not interact or react with each other. Hence, they can be given together to get the best results. Tylenol, which contains acetaminophen, is an antipyretic and pain reliever used to treat fever and pain. It includes common side effects such as dark urine, abdominal pain, rash, itching, dizziness, and swelling.

Tylenol can be used at any stage of pregnancy and even during breastfeeding because acetaminophen is released in very small amounts through breast milk and therefore cannot affect the infant or newborn.

Major side effects include severe liver damage. Our liver processes Tylenol and releases some substances. Consuming more of this medicine results in an increase in this substance, resulting in severe liver damage. Some of the main symptoms of liver damage include jaundice, vomiting, nausea, pale skin, unusual bleeding, fatigue, increased sweating, and abdominal pain. Side effects can also be seen after the completion of dosages.

Benadryl’s generic name is diphenhydramine, an antihistamine used to treat dizziness, nausea, vomiting, runny nose, and sneezing. Just like Tylenol, it also includes common side effects such as constipation, dry mouth/throat/nose, fatigue, fatigue, insomnia, drowsiness, etc.

Benadryl is released into breast milk, which may affect the infant or a newborn. Hence, Benadryl is not recommended during pregnancy or nursing mothers. The main side effects include fast and irregular heartbeat, mood swings, or anxiety. A doctor should be contacted immediately if he/she notices any symptoms.


It can be concluded that drugs have many side effects and should only be used as prescribed by a doctor. Tylenol contains acetaminophen, which is used to treat mild to moderate fever and pain, but in addition to being effective and popular, it is also a major cause of acute liver failure.

Benadryl consists of diphenhydramine, which reverses the action of histamine on the capillaries, resulting in a reduction in allergic symptoms. Apart from these results, it also leads to high blood pressure levels, irregular heartbeat, mood swings, dizziness and more. Every coin has two sides, and medicines must be used carefully to get the best results. One should try ancient Indian medicines such as ginger, honey, and tulsi to get rid of colds, nausea, etc. If it is not cured, then only one should go for the medicines.


  1. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1465-7295.1989.tb00792.x
  2. https://www.tandfonline.com/doi /abs/10.1080 /10510978809363234

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Sandeep Bhandari

Sandeep Bhandari is the founder of ExactlyHowLong.com.

I am a professional full-time blogger, internet marketer and trainer. I love everything connected with the Internet and every day I try to learn new technologies.

All team management, content creation and monetization tasks fall on me. Together with the ExactlyHowLong team, we strive to provide our readers with useful and interesting content.

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In short, if it’s creative and you can do it digitally, I love it.

What do you think?

Zyrtec vs Benadryl: Difference & Comparison

Some people get viruses and infections easily. They may not be fatal to overall health, but they can certainly be very annoying in daily activities.

Health quiz

Test your knowledge of health related topics

1 / 10

The thick, oily, dark liquid produced when tobacco is burned is called ___________.





2 / 10

What is the main cause of male infertility?

Poor diet


Lack of physical activity

Low sperm count

3 / 10

How many chambers are there in the heart?

4 / 10

Substances found in food that help your body grow and develop.

Protein products




5 / 10

What is the best way to prevent the onset of depression?

Exercise regularly

Eat a healthy diet

Get enough sleep

All of the above

6 / 10

What is the main cause of cardiovascular disease?

Lack of exercise


Poor nutrition


7 / 10

What is the best way to reduce the risk of cardiovascular disease?

No smoking

Diet low in saturated fat

Maintaining a healthy weight

All of the above

8 / 10

Many children with asthma experience more severe reactions when they breathe ___________________.

Passive smoking

Carbon dioxide



9 / 10

What is the main cause of the common cold?




None of the above

10 / 10

Which of the following is NOT a symptom of a cold?

Sore throat

Runny nose

Upset stomach


your account

And these viruses travel at high speed these days. In some cases, if they are not treated in time, they can be quite serious in the future.

And they don’t always require a visit to a doctor. Sometimes they can also be treated at home by taking medication.

These drugs can be easily found in any medical store. Examples of such drugs are Zyrtec and Benadryl.

Both serve the same purpose; therefore, it is important to understand the difference between using them whenever they are required.

Key Findings

  1. Zyrtec is a second generation antihistamine and Benadryl is a first generation antihistamine that causes less drowsiness and fewer side effects.
  2. Zyrtec provides longer lasting relief from allergy symptoms than Benadryl, which requires more frequent dosing.
  3. Benadryl works faster for symptom relief but is less effective than Zyrtec for long-term or chronic allergies.

Zyrtec vs Benadryl

Zyrtec is a medicine used to relieve allergy symptoms such as sneezing, runny nose, itching and watery eyes. It is used to treat hay fever and other respiratory allergies caused by pollen. Benadryl is a medication used to relieve allergy symptoms. It is also used as a sleep aid.

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Zyrtec is a medicine taken for problems such as sneezing, runny nose, itching, watery eyes, etc., in simple words, and they are used to treat colds, headaches, body aches and chronic urticaria (urticaria).

This medicine may cause severe allergies in some people. And some people need to take proper precautions during or before taking this medicine. They can be taken for months, and the dosage varies according to age.

Benadryl is a liquid cough medicine or syrup used primarily for one or the sole purpose of treating coughs. But in some cases it can also be used to treat skin rashes, itching, allergic symptoms, etc.

These medicines should not be overdosed as they can lead to oversleeping and other serious problems. And in case of any symptoms of overdose, you should consult a doctor.

Comparison chart

901 52 Generation of antihistamines
Comparison parameters Zyrtec Benadryl
Generic name Cetirizine hydrochloride Diphenhydramine hydrochloride
allergic More than Relatively less
Second, Name
Side effects Less More
Nausea Yes No

It is used to reduce the effects of the natural chemical histamine. A doctor should be consulted before using this medicine, as some of its ingredients may cause allergies in many people.

It can also cause hallucinations and problems with thinking. All pregnant and lactating women should avoid this medicine.

Precautions to take before taking this medicine:

  • People who are allergic to cetirizine or levocetirizine should avoid this medicine.
  • People with serious medical conditions should also consult their doctor first.

How to take this medicine:

  • Should be taken monthly.
  • Take it as directed on the label.
  • Elderly people should consult a physician before taking or reduce the dose.
  • It can be taken with or without food.
  • The tablet should be allowed to dissolve in the mouth and should not be swallowed whole. The aid of water or liquid can also help the dissolution process.

In case of missing a dose, the next dose should be taken immediately as soon as it is recognized, but overdose should be avoided at all costs and the following are some of the symptoms of overdose:

  • Vision problems.
  • Feeling of anxiety.
  • Agitation.
  • Abdominal pain.
  • Trouble walking.

In addition, you should immediately consult a specialist if you notice some other or unusual symptoms.

What is Benadryl?

This is a syrup used to treat coughs. It can be taken with or without food. The dosage of this syrup depends on the condition.

And it should be taken either until the problem is cured or until the doctor suggests it. Stopping earlier may cause the problem to return.

Some abuse this medicine to put a child or infant to sleep, which is wrong. Heavy activities should be avoided after drinking the syrup.

Alcohol should also be avoided while taking Benadryl.

A physician should be consulted if the user suffers or suffers from any of the following conditions:

  • Blockage in the stomach or intestines.
  • Problem with urination.
  • Any disease of the kidneys or liver.
  • Any disease of the respiratory system, such as asthma.
  • Heart diseases.
  • And during pregnancy.

In case of overdose, contact a specialist immediately. And side effects from it can be:

  • Difficulty in the process of urination.
  • Dizziness.
  • Unknown tongue movements.
  • Constipation.
  • Or any other various symptoms.

Main differences between Zyrtec and Benadryl

  1. The main difference between Zyrtec and Benadryl is that they are different generations of antihistamines; Zyrtec is a second generation antihistamine while Benadryl is a first generation antihistamine.
  2. They both have different common names. Zyrtec’s generic name is cetirizine hydrochloride while Benadryl is diphenhydramine hydrochloride.
  3. Although both can cause allergic reactions in humans, in comparison, Zyrtec is more allergic in humans, this may be due to its components, etc. , while Benadryl is relatively less allergic.
  4. Although Zyrtec is more allergic, people have fewer side effects, such as vision problems, feelings of anxiety, etc. On the contrary, Benadryl has more side effects, as it can cause excessive and immediate sleep, unknown movements tongue, constant dizziness. etc. a person can perform heavy activities after consuming Zyrtec. However, he won’t be able to do so after taking Benadryl.
  5. They have several similar symptoms and side effects, but one side effect of Zyrtec is missing from Benadryl Nausea. A person may feel nauseous or feel like throwing up, but this side effect is not observed after consuming Benadryl.


  1. https://www.sciencedirect.com/science/article/pii/S0091674


  2. https://www.cochranelibrary.com/cdsr/doi/10.1 002/14651858.CD001267/abstract
  3. https://www.sciencedirect.com/science/article/pii/S0091674911014084
  4. https://link.