How does estrogen affect joint pain during menstruation and menopause. What are the main functions of estrogen in the female body. Can hormonal changes lead to increased joint discomfort. How can women manage joint pain associated with hormonal fluctuations.

The Role of Estrogen in Women’s Health

Estrogen, often referred to as the female sex hormone, plays a crucial role in various bodily functions. Primarily produced in the ovaries, this hormone group consists of estrone, estradiol, and estriol. Each type of estrogen serves specific purposes throughout a woman’s life, from puberty to menopause.

Key Functions of Estrogen

• Regulates menstrual cycle
• Supports pregnancy and fetal development
• Promotes breast changes during adolescence and pregnancy
• Contributes to bone health and formation
• Affects skin, hair, and mucous membranes
• Influences pelvic muscle strength

Does estrogen impact more than just reproductive health? Indeed, this versatile hormone extends its influence far beyond sexual development. It plays a vital role in maintaining bone density, skin elasticity, and even cognitive function. As women age and estrogen levels fluctuate, these various bodily systems may experience changes, leading to symptoms such as joint pain during menstruation or menopause.

The Connection Between Estrogen and Joint Pain

Many women experience joint pain as a symptom of menstruation or menopause. This discomfort is often linked to fluctuations in estrogen levels. When estrogen production decreases, it can lead to various changes in the body that may contribute to joint pain.

How Estrogen Affects Joint Health

1. Fluid regulation: Estrogen helps maintain proper hydration in joint tissues.
2. Cartilage protection: The hormone supports the health of cartilage, which cushions joints.
3. Inflammation control: Estrogen can help reduce inflammation in the body.
4. Bone density: It plays a crucial role in maintaining bone strength.

Why do some women experience more joint pain during hormonal changes? The answer lies in the complex interplay between estrogen and the body’s tissues. As estrogen levels drop, the body may struggle to maintain proper hydration and lubrication of joint tissues, leading to increased friction and discomfort.

Menopause and Joint Pain: Unraveling the Connection

Joint pain is a common symptom experienced by many women during menopause. This discomfort can significantly impact mobility and overall quality of life. Understanding the relationship between menopause and joint pain is crucial for developing effective management strategies.

Causes of Menopausal Joint Pain

• Hormonal imbalances
• Dehydration
• Weight gain
• Nutritional deficiencies
• Poor posture
• Increased pain sensitivity

How does menopause affect joint health specifically? During menopause, the body undergoes significant hormonal changes, primarily a decrease in estrogen production. This reduction can lead to various issues, including:

1. Decreased water retention in joint tissues
2. Reduced cartilage protection
3. Increased inflammation
4. Accelerated bone loss

These factors combine to create an environment where joint pain and stiffness become more prevalent, especially in high-impact areas such as the hips and knees.

The Impact of Hormonal Fluctuations on Joint Comfort

Hormonal changes throughout a woman’s life can significantly influence joint health and comfort. From the monthly menstrual cycle to the transition into menopause, these fluctuations can lead to varying degrees of joint pain and stiffness.

Estrogen’s Role in Joint Lubrication

Is there a direct link between estrogen levels and joint lubrication? Research suggests that estrogen plays a crucial role in maintaining proper hydration and lubrication of joint tissues. When estrogen levels drop, the body may struggle to retain water effectively, leading to:

• Reduced synovial fluid production
• Decreased cartilage hydration
• Less flexible ligaments and tendons
• Increased friction between joint surfaces

These changes can result in joint discomfort, stiffness, and reduced range of motion, particularly noticeable during hormonal fluctuations associated with menstruation and menopause.

Managing Joint Pain During Hormonal Changes

While joint pain related to hormonal changes can be challenging, there are several strategies women can employ to manage discomfort and maintain joint health.

Lifestyle Modifications for Joint Health

• Regular exercise: Low-impact activities like swimming or yoga
• Maintaining a healthy weight: Reduces stress on joints
• Proper nutrition: Focus on anti-inflammatory foods
• Adequate hydration: Supports joint lubrication
• Stress management: Reduces overall inflammation
• Good posture: Minimizes unnecessary joint strain

Can dietary changes help alleviate hormone-related joint pain? Absolutely. A diet rich in omega-3 fatty acids, antioxidants, and calcium can support joint health and potentially reduce inflammation. Additionally, staying well-hydrated is crucial for maintaining proper joint lubrication.

Medical Interventions and Supplements

In some cases, medical interventions or supplements may be necessary to manage joint pain effectively. Options may include:

1. Hormone replacement therapy (under medical supervision)
2. Over-the-counter pain relievers
3. Glucosamine and chondroitin supplements
4. Calcium and vitamin D supplements
5. Topical pain relief creams

It’s important to consult with a healthcare provider before starting any new treatment regimen, as individual needs may vary.

The Importance of Early Detection and Treatment

Recognizing and addressing joint pain early is crucial for maintaining long-term joint health and overall quality of life. Women experiencing persistent joint discomfort, especially if it coincides with hormonal changes, should seek medical advice promptly.

Signs to Watch For

• Morning stiffness lasting more than 30 minutes
• Pain that worsens with activity
• Swelling or warmth in the joints
• Reduced range of motion
• Persistent fatigue

Why is early intervention so important? Addressing joint pain in its early stages can help prevent further damage and potentially slow the progression of any underlying conditions. Additionally, early treatment can improve overall comfort and maintain mobility, allowing women to continue engaging in their daily activities with less disruption.

Future Perspectives: Research and Innovations in Hormone-Related Joint Pain

As our understanding of the relationship between hormones and joint health continues to evolve, researchers are exploring new avenues for treatment and prevention of hormone-related joint pain.

Promising Areas of Research

• Targeted hormone therapies with fewer side effects
• Novel anti-inflammatory compounds
• Gene therapies for joint tissue regeneration
• Advanced imaging techniques for early detection of joint changes
• Personalized treatment approaches based on genetic profiles

What potential breakthroughs are on the horizon for managing hormone-related joint pain? Some exciting areas of investigation include:

1. Development of selective estrogen receptor modulators (SERMs) that target specific tissues
2. Exploration of plant-based compounds that mimic estrogen’s beneficial effects on joints
3. Advancements in regenerative medicine to repair and rejuvenate joint tissues
4. Integration of artificial intelligence in predicting and managing hormonal fluctuations

These innovative approaches hold promise for improving the quality of life for women experiencing joint pain related to hormonal changes.

In conclusion, understanding the complex relationship between estrogen and joint pain is crucial for women navigating the challenges of menstruation and menopause. By recognizing the signs of hormone-related joint discomfort and adopting proactive management strategies, women can maintain their joint health and overall well-being throughout these significant life transitions. As research continues to advance, we can look forward to even more effective and personalized approaches to addressing this common issue, empowering women to lead active, comfortable lives regardless of hormonal fluctuations.

Estrogen and joint pain during menstruation or menopause

This is an automatically translated article.

Joint pain is one of the most common symptoms of menstruation or menopause. If you feel a little stiff and painful in your joints, especially in the morning, you should go to a medical facility for an examination to control your symptoms.

1. What is estrogen?

Estrogen is an important hormone for sexual and reproductive development, mainly in women. They are also known as female sex hormones. The term “estrogen” refers to all the chemically similar hormones in this group, namely estrone, estradiol (mainly in women of reproductive age), and estriol.

2. Function of Estrogen

In women, estrogen is produced mainly in the ovaries. The ovaries are grape-sized glands located inside the uterus and are part of the endocrine system. Therefore, estrogen has the following functions:
Estrogen is produced by fat cells and the adrenal glands, helps to regulate the menstrual cycle, controls the growth of the lining of the uterus during the first part of the cycle. If the egg is fertilized, estrogen works with progesterone to prevent ovulation during pregnancy. During pregnancy, the placenta produces estrogen, specifically the hormone estriol. Estrogen controls lactation and other breast changes, both during adolescence and during pregnancy. Estrogen plays an important role in bone formation, working with vitamin D, calcium and other hormones to effectively break down and rebuild bone according to the body’s natural process. As estrogen levels begin to decline in middle age, bone rebuilding slows down. For post-menopausal women, more bone is broken down than is produced. This is why postmenopausal women are four times more likely to have joint pain and osteoporosis than men. Estrogen even affects the skin, hair, mucous membranes, and pelvic muscles. For example, estrogen can make the skin darker. Some researchers hope to use this information to create fake skin creams that are safe by triggering estrogen’s tanning response, without causing other hormone-induced changes in the body. .

Estrogen có tác dụng điều hòa chu kỳ kinh nguyệt

3. Can menopause cause joint pain?

Joint pain is one of the common menopause symptoms, reducing mobility and flexibility. The causes of joint pain in menopause and how to treat and prevent it are all related to lifestyle, diet, naturopathy and supplements.
While joint pain and stiffness is inevitable as we age, when women reach menopause, typically between the ages of 45 and 55, they are often surprised to discover that joint pain is a among the most common symptoms aside from nighttime hot flashes, sweating, menstrual cycle changes, and mood swings.
Joints involved in high impact movements such as hips and knees are most commonly affected. Elbows, neck, shoulders, hands, and fingers can also be affected by joint pain.
Some causes of joint pain during menopause include:
Hormonal disorders. Loss of water. Weight gain. Improper diet. Poor posture. Increased sensitivity to pain.

4. How do hormonal changes affect joint pain?

Decreased estrogen levels are thought to be one of the main causes of joint pain during menopause. When you reach menopause, the level of estrogen in your body begins to drop. Estrogen is responsible for regulating fluid levels in the body, so if levels of this hormone are low, the body becomes less able to retain water, affecting the hydration and lubrication of joint tissues, including cartilage, ligaments and tendons.
Up to 80% of cartilage is water, they act as a cushion between bones, absorbing shock and reducing friction. Water is also a natural part of synovial fluid, which helps joints move without creating friction.
Water is also needed to help support the flexibility and elasticity of ligaments and tendons. Ligaments connect one bone to another and are necessary for joint stability, while tendons connect your muscles to bones. As ligaments and tendons lose their elasticity, your range and ease of movement can be reduced.
Therefore, without enough water, the flexibility and lubricating ability of joint tissues can be affected. When this protective and supportive property is impaired, it can cause pain and stiffness.
In short, when you reach menopause, the level of estrogen in your body starts to drop. Estrogen is responsible for regulating fluid levels in the body, so if levels of this hormone are low, the body becomes less able to retain water, affecting the hydration and lubrication of joint tissues, including cartilage, ligaments and tendons.

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References: Healthline.com, Pubmed.ncbi.nlm.nih.gov

XEM THÊM:

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Joint Pain and Women – Women’s Health

Everyone gets the occasional ache or pain — a little soreness in the shoulder, a twinge in the knee — but research shows that women are more frequently and often more severely affected than men. The CDC estimates that from arthritis or chronic joint symptoms affect more than 70 million Americans, 41 million of whom are women. A number of factors contribute to this disparity: Women are more apt than men to have conditions that cause joint pain, experience hormone fluctuations that affect their vulnerability, and may not be physiologically equipped to deal with pain.

Causes of Joint Pain in Women

Of the nearly 27 million Americans with osteoarthritis (AO), 60 percent are women. Rheumatoid arthritis (RA), an autoimmune disease, strikes approximately three times more women than men. Other autoimmune conditions that cause joint pain, such as lupus, scleroderma, and multiple sclerosis (MS), also hit women harder than men: Women are nine times more likely to develop lupus, three times more likely to have scleroderma, and twice as likely to suffer from MS. And fibromyalgia, a little understood condition that can cause joint pain, affects women eight times more frequently than men.

The Estrogen-Joint Pain Connection

“Women typically feel pain more intensively, more often, and in more parts of the body than men,” says Tarvez Tucker, MD, a pain specialist and director of the Pain Clinic at the University of Kentucky Medical Center, in Lexington. Female hormones are believed to play a role in women’s high vulnerability to pain. Many women with OA, RA, lupus, and fibromyalgia report an increase in joint pain just before or during their periods. This is likely because estrogen levels plummet right before menstruation and rise again after a woman’s period is over. “Estrogen is believed to be protective against pain,” says Dr. Tucker. “It peaks during pregnancy, probably to protect women from the pain of childbirth.” Some research shows that 80 percent of women with RA experience a remission of symptoms during pregnancy and a flare-up when estrogen dips during the postpartum period. Additionally, reproductive hormones are suspected as factors in the high incidence of autoimmune diseases in women since conditions such as RA and lupus are most common during the childbearing years.

Women’s Bodies and Joint Pain

Hormones are only part of the picture, however. Female brains may be wired for pain. It’s thought that endorphins, the body’s natural painkillers, work more effectively in men than in women. “Studies have found that females release less of the brain chemical dopamine in response to painful stimulation. Without dopamine, endorphins can’t function effectively,” says Patrick Wood, MD, a pain researcher at Louisiana State University, in Shreveport, and medical advisor to the National Fibromyalgia Association.

Female structural differences may contribute to some kinds of joint pain, too. For example, women are more prone to osteoarthritis of the knee. One possible explanation: “Women tend to be more limber and loose-jointed than men, so there’s more movement in that area, increasing the risk that the kneecap will rub on the bones below it,” notes Bruce Solitar, MD, a rheumatologist at the NYU Hospital for Joint Diseases, in New York City. This may lead to osteoarthritis symptoms in the knee area.

Joint Pain Medication and Women

Women react differently than men to some medications for relieving joint pain. For example, fluctuating hormone levels can reduce the amount of medicine circulating in the bloodstream, which means that women may need more of the standard dose. Plus, female digestive systems are slower, causing certain medications (like pain relievers) to take more time to pass through the digestive tract where they’re absorbed more fully. And because pain sensitivity increases right before a woman’s period, more pain-relieving medicine may be required at this time of the month. “Women need to be aware of these factors, ask the right questions, and be persistent about getting an accurate diagnosis and proper treatment,” says Dr. Tucker. By becoming educated about how joint pain affects them, women can increase the odds of finding relief and getting the best health care possible.

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Muscles hurt during menstruation – Body aches before menstruation

1. home

2. About the pain

3. Periodic pain

August 30, 2021
Period pain

Many women are told about the imminent onset of menstruation not only
calendar, but also the appearance of premenstrual symptoms, which can
disrupt the habitual way of life. One of the symptoms is pain and aches in the muscles.
Let’s find out why there is muscle pain before and during menstruation,
what else can cause such complaints and how you can alleviate the condition.

Why does the whole body hurt during menstruation?

Pain during menstruation is a common phenomenon, its frequency
reaches 90% ¹ . In addition to the classic menstrual pains in
abdomen, women may experience pain in the joints, lower extremities, back
and muscles, feeling of numbness of hands and feet, coldness
limbs ^2.14 . For some, pain may occur sporadically, and
some are stalked throughout their reproductive
age ⁹ . Causes of muscle pain and body aches during menstruation
may be different.

During adolescence and young age

Relative hyperestrogenism

excess estrogen against the background of insufficient production of progesterone ³ . Estrogens
increase uterine contractions, while progesterone, on the contrary, inhibits
excessive contractile activity. With a lack in the body
progesterone increases the action of prostaglandins, which cause spasm
myometrium and muscles of other pelvic organs. Prostaglandins work
on nerve endings, due to which susceptibility to pain is greatly
increases ^3.4 . This is the mechanism of development, the so-called primary dysmenorrhea,
which usually occurs in adolescence 1-3 years after
menarche, with the onset of ovulation ² .

Vitamin deficiency

Vitamin D deficiency has been shown to cause myopathy (muscle damage)
¹⁵ . Atrophy of individual muscle groups can provoke
mechanical stress in intact muscles due to their overload, which can
be the basis for the formation of pain zones in the muscles ¹⁵ . Besides,
increased perception of pain may be due to a lack of B vitamins
B, which normally have a neuroprotective, sedative and analgesic effect
action ^16.17 .

Weak connective tissue syndrome

May be associated with congenital or acquired magnesium deficiency ¹⁸ .
Magnesium deficiency is possible with hyperestrogenism, when the mineral is intensely
washed out of the bone tissue. Violation of magnesium metabolism leads to an increase
the rate of collagen breakdown, which occurs with connective dysplasia
fabric, which in 9times the risk of developing primary dysmenorrhea
for girls ⁶ .

Risk factors for developing muscle pain during
dysmenorrhea characteristic of adult age

Gynecological pathology and previous
operations . A common cause of muscle pain, especially affecting
pelvic floor muscles, is a gynecological pathology ⁸ . At
this chronic pain is localized in the lower abdomen, lower back, in
region of the sacrum. Pain can spread to muscles and fascia from the focus
inflammation or endometriosis in the pelvis, causing symptoms of secondary
dysmenorrhea ^{2. 9} .

Chronic inflammatory process of small organs
pelvis can lead to secondary endocrine disorders, decrease
progesterone synthesis and lowering the threshold of pain sensitivity due to
prolonged existence of pain ⁹ .

Degenerative diseases of the lumbosacral
spine section . If the lower spine is affected, then
pain can spread to the pelvic organs and legs. So, when involved in
pathological process of the lumbar roots pain, sensations
tingling, burning in the thighs, groin, lower abdomen, external
genitals, knees and legs. Muscle pain may accompany
osteochondrosis and other degenerative diseases of the lower part
spine. Due to pain, the muscle contracts, tenses, muscle
spasm, and the spasm makes the pain worse ¹⁰ .

Perimenopausal

Decrease in the level of sex hormones

In women during the menopausal transition, work gradually fades
ovaries, the number of follicles decreases, the production of female
sex hormones. Without estrogen, muscle mass decreases
fibers, degenerative processes begin in the muscles. Decreased muscle
strength, endurance, fatigue quickly appears. No estrogen protection
metabolism is disturbed: the sensitivity of muscle cells decreases
to glucose, lipid metabolism is disturbed, in the vessels that feed the muscles,
the process of fat deposition begins. Muscles starve without glucose
and against the background of insufficient blood circulation, processes are activated
oxidation, which is manifested by muscle pain and swelling ¹¹ .

Exacerbation of inflammatory diseases of the joints

During menstruation, the body releases inflammatory mediators:
prostaglandins, interleukins, cytokines, which can lead to
exacerbation of chronic musculoskeletal diseases. laboratory
C-reactive protein is an indicator of an acute inflammatory process.
(SRP). Its highest content is recorded during menstruation.
It has been observed that the more severe the menstrual symptoms
(especially mood swings and pain), the higher the content
SRP ¹² .

Osteoporosis

Articular and, consequently, muscle pain, may manifest
osteoporosis. Against the background of estrogen deficiency, bone metabolism is disturbed:
the process of its formation slows down, and its destruction is activated. In
Osteoporosis is more common during menopause than during other
life periods. Bone tissue is a storehouse of minerals, for example:
calcium, magnesium, phosphorus. Deficiency of these minerals can manifest
painful cramps in the calf muscles ¹¹ .

Premenstrual syndrome and body pain

PMS may present with muscle pain in combination with other symptoms.
The prevalence of PMS varies from 18% to 92%, and the age of the highest
vulnerability varies between 25 and 35 years ⁷ . As intended by nature,
for its optimal functioning, a mature female body must be under
well-coordinated and rather monotonous effect of sex hormones. This means,
that a woman from the beginning of menstruation to menopause must be either pregnant,
either by a nursing mother, and hormone fluctuations are allowed only for
conception ³ .

At present, such a large number
pregnancies are rare, so menstrual cycles are accompanied
sharp hormonal fluctuations ³ . premenstrual syndrome and
dysmenorrhea often coexist. Perhaps they are combined
general mechanisms of development, including the role of prostaglandins. Besides,
they are linked by psychosocial factors: dysmenorrhea pain
provokes negative thoughts that make them even more pronounced
manifestations of PMS ¹ .

PMS is more likely to develop in
women engaged in mental work, suffering from vegetative
dystonia, 4 times more often – with a lack of body weight ⁷ .

Classification
syndrome

Painful periods are not the norm, but a disease that is called
“dysmenorrhea”. Especially severe dysmenorrhea can occur accompanied by
premenstrual syndrome, when a set of painful, painful symptoms
expands. In addition, dysmenorrhea can act as a bright
a sign of other pathological processes in the body that are aggravated
during menstruation.

Dysmenorrhea occurs

² :

• Primary. Considered a functional disorder because
  no damage to the structure of the reproductive organs can be identified.
  May begin as early as adolescence, 1–3 years after the first
  menses.
• Secondary. Symptoms often appear several years after onset
  monthly. Secondary dysmenorrhea always has an organic cause –
  changes in the pelvic organs: inflammation, endometriosis, adhesions.
  The influence of external factors is not excluded, for example, the use
  intrauterine device, etc. ¹

Also manifestations of dysmenorrhea vary in severity

² :

• Mild — pain is mild, daily activity is not reduced.
• Moderate Significant pain, decreased daily activities,
  which can be maintained by taking painkillers.
• Severe – in addition to severe pain, there are other symptoms (headache
  pain, nausea, vomiting, diarrhea, etc.). Painkillers are ineffective.

Treatment of dysmenorrhea

Treatment of dysmenorrhea using drugs in combination with non-drug
methods. Non-drug therapy should begin with lifestyle changes.
It is recommended to exclude psycho-emotional and physical overloads,
long (7-8 hours) night sleep, moderate physical activity is required
load. A good result is walking, jogging, cycling.
You can choose an activity according to your interests – dancing, step aerobics, yoga ^4,
7.14 .

Foods that contribute to fluid retention should be removed from the menu.
body (salt, sugar, alcohol), and to improve digestion it is worth
add complex carbohydrates (cereals, nuts, cereals) and fiber (vegetables,
fruit) ^{4, 7} :

Is it possible to self-medicate?

In most cases, without pharmacotherapy aimed at normalization
menstrual cycle and a decrease in the level of prostaglandins, bypass
not possible ¹² . For treatment to be effective, it is important
to establish the cause of pain, their nature and other features of the body.
Therefore, there is no need to postpone the visit to the doctor until later.

Drug treatment

Several groups are used to treat dysmenorrhea
preparations ^3.9 :

• multivitamins;
• preparations of magnesium;
• nonsteroidal analgesics;
• antispasmodics;
• hormonal preparations (combined oral contraceptives,
  gestagens) and others.

Although the treatment of muscle soreness should be individualized in
each case, it usually starts with painkillers. As
non-narcotic pain reliever (analgesic)
paracetamol has proven itself: it was effective as an emergency
to relieve acute pain, as well as in the long-term treatment of chronic
pain syndromes. According to scientific studies, paracetamol is not
inferior in analgesic effect to non-steroidal anti-inflammatory
drugs, but, unlike them, has a low risk of complications with
aspects of the cardiovascular and digestive systems ¹⁹ .

The combination of the antispasmodic drotaverine and the non-narcotic analgesic paracetamol acts selectively for spasm and specifically for pain ¹³ .

Read more

The main goal of dysmenorrhea care is to reduce or eliminate pain
lower abdomen. Paracetamol is considered the drug of choice for the treatment of pain in
menstruation ²⁰ Paracetamol blocks the formation of prostaglandins and
thus reducing the severity of pain sensations ¹³ .

As an adjunct to the treatment of dysmenorrhea to control pain caused by
spasm of smooth muscles, antispasmodics may be prescribed. Antispasmodic
drotaverine blocks excessive uterine contractions, improves blood circulation
organ, which may contribute to pain relief in dysmenorrhea ⁹ .

No-shpa® Duo contains
paracetamol and drotaverine, and therefore has a double action of an analgesic and
antispasmodic. No-shpa® Duo
Helps relieve symptoms of mild to moderate dysmenorrhea
gravity ¹³ .

Find out more about
No-shpa® Duo

find out

Show
sources

MAT-EN-2103226 – 3.0 – 03/2022

PMS – premenstrual syndrome.

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