What are the key uses and benefits of L-tyrosine. How can it impact mood, stress, sleep, and more. Get the answers to your questions about this essential amino acid.

Understanding L-Tyrosine: An Integral Amino Acid

L-tyrosine is a non-essential amino acid that the body can synthesize from another amino acid called phenylalanine. It plays a crucial role in the production of several important neurotransmitters, including epinephrine, norepinephrine, and dopamine, which are responsible for regulating mood, cognition, and overall brain function.

The Significance of Tyrosine in the Body

Tyrosine is an essential component in the synthesis of melanin, the pigment that determines hair and skin color. It also contributes to the proper functioning of the adrenal, thyroid, and pituitary glands, which are responsible for hormone production and regulation. Tyrosine is involved in the structure of almost every protein in the body, making it a widely utilized and important amino acid.

Addressing Tyrosine Deficiency

While tyrosine deficiency is rare, it has been associated with low blood pressure, low body temperature, and an underactive thyroid. However, it is important to note that taking tyrosine supplements does not necessarily alleviate these conditions, as the underlying causes may be more complex.

Tyrosine and Phenylketonuria (PKU)

Phenylketonuria (PKU) is a serious genetic condition in which the body cannot properly metabolize the amino acid phenylalanine. This can lead to brain damage and intellectual disability. People with PKU must strictly avoid any sources of phenylalanine in their diet, which can also result in a tyrosine deficiency. In these cases, tyrosine supplements may be prescribed to maintain appropriate levels.

Tyrosine and Stress Response

Tyrosine plays a crucial role in the production of the stress-related neurotransmitters epinephrine and norepinephrine. Some research suggests that under conditions of psychological stress, the body may not be able to effectively convert phenylalanine into tyrosine, potentially leading to a relative deficiency. Studies indicate that tyrosine supplements may help improve memory and performance under stressful circumstances, but more research is needed to fully understand this relationship.

Tyrosine and Sleep Deprivation

One study has suggested that taking tyrosine supplements may help individuals maintain alertness and cognitive function after experiencing sleep deprivation. However, further research is required to confirm and expand upon these findings.

Other Potential Applications of Tyrosine

While some athletes claim that tyrosine supplements can enhance their performance, there is currently no conclusive evidence to support this claim. Additionally, preliminary research suggests that tyrosine kinase inhibitors may play a role in the treatment of thyroid cancer and may help improve lung function in individuals with lung cancer or pulmonary fibrosis, but more studies are needed to validate these potential applications.

Dietary Sources and Supplementation

Tyrosine is found in a variety of food sources, including soy products, poultry, fish, nuts, seeds, dairy products, and certain legumes. Tyrosine is also available as a dietary supplement, typically in capsule or tablet form.

Dosage and Considerations

When taking tyrosine supplements, it is recommended to take them at least 30 minutes before meals, divided into three daily doses. Supplementing with vitamins B6, B9 (folate), and copper can help the body effectively convert tyrosine into the necessary neurotransmitters. It is important to consult with a healthcare professional before starting any tyrosine supplementation, especially for children or individuals with pre-existing medical conditions.

In conclusion, L-tyrosine is a versatile and essential amino acid with a wide range of functions in the human body. From its role in neurotransmitter production to its involvement in stress response and potential applications in various medical conditions, tyrosine is a key player in maintaining overall health and well-being. By understanding the benefits and proper use of tyrosine, individuals can make informed decisions about incorporating it into their diet or supplementation regimen, always in consultation with a healthcare professional.

Tyrosine Information | Mount Sinai

L-tyrosine

Tyrosine is a nonessential amino acid the body makes from another amino acid called phenylalanine. It is an essential component for the production of several important brain chemicals called neurotransmitters, including epinephrine, norepinephrine, and dopamine. Neurotransmitters help nerve cells communicate and influence mood. Tyrosine also helps produce melanin, the pigment responsible for hair and skin color. It helps in the function of organs responsible for making and regulating hormones, including the adrenal, thyroid, and pituitary glands. It is involved in the structure of almost every protein in the body.

It’s rare to be deficient in tyrosine. Low levels have been associated with low blood pressure, low body temperature, and an underactive thyroid. This does not mean, however, that taking tyrosine supplements will help any of these conditions.

Phenylketonuria (PKU)

This serious condition occurs in people whose bodies can’t use the amino acid phenylalanine. It can lead to brain damage, including intellectual disability. People with PKU must avoid any phenylalanine in their diets. Because tyrosine is made from phenylalanine, people with PKU can be deficient in tyrosine. Tyrosine is used in protein supplements for people with PKU, but most doctors don’t recommend more tyrosine supplements. If you have PKU, your doctor will determine if you need more tyrosine and how much.

Stress

Tyrosine is involved in the production of the stress neurotransmitters epinephrine and norepinephrine. Some researchers believe that, under stress, the body isn’t able to make enough tyrosine from phenylalanine. Some animal and human studies suggest that tyrosine supplements may help improve memory and performance under psychological stress. More research is needed.

Sleep deprivation

One study suggests that taking tyrosine may help you be more alert after sleep deprivation. More research is needed.

Other

Some athletes claim that tyrosine helps their performance. However, there is no proof that this claim is true or safe.

Because tyrosine helps the body produce the mood-influencing chemical dopamine, and because people who are depressed often have low levels of tyrosine, researchers thought that tyrosine might help treat depression. However, studies have found that it has no effect.

Preliminary research suggests that tyrosine kinase inhibitors may play a role in the treatment of thyroid cancer. Other studies suggest tyrosine kinase inhibitors may help improve lung function among people who have lung cancer or pulminary fibrosis. More research is needed.

Dietary Sources

Tyrosine is found in soy products, chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, and sesame seeds.

Available Forms

Tyrosine is also available as a dietary supplement, in capsule or tablet form.

How to Take It

Take tyrosine supplements at least 30 minutes before meals, divided into 3 daily doses. Taking vitamins B6, B9 (folate), and copper along with tyrosine helps the body convert tyrosine into important brain chemicals.

Pediatric

Don’t give tyrosine supplements to a child without first asking your doctor.

Adult

Doses vary. Talk to your nutritionist or doctor about what dose is right for you. To treat symptoms of sleep deprivation, one study used 150 mg per kilogram of body weight per day.

Precautions

Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.

People who have migraine headaches should avoid tyrosine, as it can trigger migraine headaches and stomach upset.

People with hyperthyroidism or Graves disease should avoid tyrosine supplements because tyrosine may increase levels of thyroid hormone.

Possible Interactions

If you are being treated with any of the following medications, you should not use tyrosine supplements without first talking to your health care provider.

Monoamine Oxidase Inhibitors (MAOIs) — Tyrosine may cause a severe increase in blood pressure in people taking antidepressant medications known as MAOIs. This rapid increase in blood pressure, also called “hypertensive crisis,” can lead to a heart attack or stroke. People taking MAOIs should avoid foods and supplements containing tyrosine. MAOIs include:

• Isocarboxazid (Marplan)
• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Selegiline

Thyroid hormone — Tyrosine is a precursor to thyroid hormone, so it might raise levels too high when taken with synthetic thyroid hormones.

Levodopa (L-dopa) — Tyrosine should not be taken at the same time as levodopa, a medication used to treat Parkinson’s disease. Levodopa may interfere with the absorption of tyrosine.

Supporting Research

Carhill AA, et al. The noninvestigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and monitoring. J Clin Endocrinol Metab. 2013;98(1):31-42.

Fernstrom JD. Can nutrient supplements modify brain function? Am J Clin Nutr. 2000;71(6 Suppl):1669S-1675S.

Hoffman JR, Ratamess NA, Gonzalez A, Beller NA, Hoffman MW, Olson M, Purpura M, Jäger R. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. J Int Soc Sports Nutr. 2010 Dec 15;7:39.

Kliegman R, Behrman R, Jenson H, Stanton B. Nelson Textbook of Pediatrics, 19th ed. Philadelphia, PA: Saunders Elsevier; 2011.

Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. 2007 May 22; [Epub ahead of print]

Melmed: Williams Textbook of Endocrinology, 12th ed. Philadelphia, PA: Saunders Elsevier; 2011.

Meyers S. Use of neurotransmitter precursors for treatment of depression. Altern Med Rev. 2000;5(1):64-71.

Parry BL. The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications. CNS Drugs. 2001;15(4):277-285.

Poustie VJ, Rutherford P. Tyrosine supplementation for phenylketonuria. Cochrane Database Syst Rev. 2000;(2):CD001507.

Richeldi L, et al. Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med. 2011;365(12):1079-87.

Thomas A, Rajan A, giaccone G. Tyrosine Kinase Inhibitors in Lung Cancer. Hematology/Oncology Clinics of North America. 2012;26(3).

Tumilty L, Davison G, Beckmann M, Thatcher R. Oral tyrosine supplementation improves exercise capacity in the heat. Eur J Appl Physiol. 2011 Mar 25. [Epub ahead of print]

van Spronsen FJ, van Rijn M, Bekhof J, Koch R, Smit PG. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr. 2001;73(2):153-157.

Webster D, Wildgoose J. Tyrosine supplementation for phenylketonuria. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD001507. Review.

Yehuda S. Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine. A new molecule. Pharmacol Biochem Behav. 2002;72(1-2):7-11.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Tyrosine is a type of amino acid, which are the building blocks of protein. The body makes tyrosine from another amino acid called phenylalanine.

In the diet, tyrosine can be eaten in dairy products, meats, fish, eggs, nuts, beans, oats, and wheat. The body uses tyrosine to make chemical messengers that are involved in conditions affecting the brain, such as mental alertness.

People most commonly use tyrosine in protein supplements for an inherited disorder called phenylketonuria (PKU). It is also used for alcohol use disorder, cocaine dependence, and memory and thinking skills, but there is no good scientific evidence to support most of these uses.

Uses & Effectiveness ?

Effective for

• An inherited disorder that increases levels of phenylalanine in the blood (phenylketonuria or PKU). People with PKU are not able to process the amino acid phenylalanine. This amino acid is used by the body to make tyrosine. To prevent tyrosine levels from becoming too low, people with PKU are advised to consume medical foods that contain tyrosine and very little phenylalanine.

Possibly Effective for

• Memory and thinking skills (cognitive function). Taking tyrosine by mouth might improve mental performance under stressful conditions.
• Memory. Taking tyrosine by mouth seems to improve memory during stressful situations.

Possibly Ineffective for

• Athletic performance. Taking tyrosine by mouth before running or cycling doesn’t seem to improve performance.

There is interest in using tyrosine for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Tyrosine is commonly consumed in foods. Tyrosine is possibly safe when taken as a medicine, short-term. It seems to be safe when taken in doses up to 150 mg/kg daily for up to 3 months. Some people experience side effects such as nausea, headache, fatigue, and heartburn.

When applied to the skin: Tyrosine is possibly safe when applied to the skin.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn’t enough reliable information to know if tyrosine is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Thyroid disorders: The body uses tyrosine to make thyroxine, a thyroid hormone. Taking extra tyrosine might increase thyroxine levels too much. This could make hyperthyroidism and Grave’s disease worse. If you have a thyroid disorder, don’t take tyrosine supplements.

Interactions ?

Moderate Interaction

Be cautious with this combination

• Tyrosine might decrease how much levodopa the body absorbs. By decreasing how much levodopa the body absorbs, tyrosine might decrease the effects of levodopa. Do not take tyrosine and levodopa at the same time.

• The body naturally produces thyroid hormones. Tyrosine might increase how much thyroid hormone the body produces. Taking tyrosine with thyroid hormone pills might cause there to be too much thyroid hormone. This could increase the effects and side effects of thyroid hormones.

Dosing

In the diet, tyrosine is found in dairy, meats, fish, eggs, nuts, beans, oats, and wheat. In supplements, tyrosine has most often been used by adults in doses of 100-300 mg/kg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2018.

✒ Tyrosine – Benefits, Side Effects & Dosage – [SAYYES]

Tyrosine is a popular dietary supplement used to improve alertness and concentration. This substance is used in the human brain to carry out a number of important chemical processes, transmit nerve impulses, and regulate mood.

Although tyrosine has several benefits, some medications may cause side effects when used with tyrosine. In order to avoid misuse of this supplement, below we will review its basic information, recommendations for use, and potential risks associated with its abuse.

What is tyrosine and what does it do? The first compound is found in common products available to everyone. However, its greatest amount is observed in cheese, where tyrosine was discovered for the first time.

This substance is also found in chicken, fish, milk, and high-protein foods.

According to research data, tyrosine is involved in the synthesis of a number of important substances for the human body, such as:

If your diet is deficient in high tyrosine foods, doctors recommend the use of appropriate nutritional supplements. Adding them to the diet can increase the amount of dopamine, adrenaline and norepinephrine, which will lead to improved memory and improve reaction in stressful situations and brain function.

Effect of tyrosine on stress levels

nii and transmission of nerve impulses. So, for example, in rodents whose body was constantly exposed to low temperatures, scientists noted a decrease in the level of neurotransmitters, which caused memory impairment. However, the use of tyrosine supplements made it possible to reverse the process and normalize brain function in animals. Although laboratory studies on rats cannot be used to confirm the effect of a substance on the human body, experiments involving humans have shown a similar result.

One study of 22 women found that adding tyrosine to the diet increased the speed of problem solving. Scientists attribute this effect to an increase in concentration levels.

Another experiment looking at the compound’s effect on cognitive flexibility found that tyrosine improved the ability to quickly switch from one task to another while maintaining performance levels. In addition, regular intake of tyrosine has been found to improve brain function in sleep-deprived people and keep their concentration levels up to 3 hours longer than placebo.

An analysis of a number of studies has shown that the addition of this compound to the diet can reverse the process of mental decline. Also, the supplement can improve the cognitive abilities of the brain in stressful and psychologically difficult situations. And despite some evidence that tyrosine can improve brain function, there is not a single study that confirms the ability of this compound to increase the level of physical performance.

The scientists also report that none of the previous studies have shown that tyrosine is able to improve brain function outside of stressful situations. In other words, the inclusion of this supplement in the diet will not improve mental abilities.

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Tyrosine can be used to treat phenylketonuria

Phenylketonuria (PKU) is a genetic disease that interferes with the synthesis of phenylalanine hydroxylase. This enzyme is used by the human body to generate neurotransmitters and also to break down phenylalanine.

The main treatment for this genetic disorder is a specialized diet that includes foods high in phenylalanine. But due to the fact that tyrosine is synthesized from this substance, individuals suffering from PKU may experience an acute deficiency of it. Based on this, the scientists concluded that tyrosine supplements can improve the condition of people with phenylketonuria.

An analysis of research data has shown that the regular use of dietary supplements of tyrosine in combination with a specialized diet for patients with PKU has a positive effect on the growth of intelligence, improves quality of life and reduces the risk of death. However, some studies have shown that there is practically no difference between the use of supplements and placebo. Therefore, it is impossible to draw unambiguous conclusions about the need for the use of tyrosine in the treatment of PKU.

Should l tyrosine be used for depression

zine can help people who are depressed. This condition is associated with an imbalance of neurotransmitters in the human brain. For its treatment, as a rule, antidepressants are prescribed, which contribute to the production of additional neurotransmitters. But because tyrosine has the same property, it can be used as an alternative to antidepressants.

Despite this, some previous studies refute this claim. So, in one of the experiments, one group with depression was given 100 milligrams of tyrosine per 1 kilogram of its own weight in combination with antidepressants, and the other amino acid was replaced with a placebo. After the study was completed, it was found that tyrosine has no effect on depression.

According to doctors, depression is a rather complex condition that varies from person to person. Therefore, the use of tyrosine in its treatment can help only a few. Despite this, the inclusion of an appropriate supplement in the diet increases the levels of adrenaline, dopamine and norepinephrine, which will provide benefits to the body.

One study in people whose depression was caused by low levels of dopamine showed that tyrosine could improve their condition. The participants in the experiment experienced an increase in the amount of energy and an increase in motivation.

The results of studies on the effect of tyrosine on depression are inconsistent. Therefore, further experiments will be required to determine the usefulness of the substance in this area.

Side effects of l-tyrosine

Doctors report that tyrosine is an absolutely safe dietary supplement, provided it is used in the recommended amounts, that is, up to 150 milligrams per 1 kilogram of body weight. Despite this, in combination with certain drugs, this compound may cause unwanted side effects.

Monoamine oxidase inhibitors (MAOIs)

Tyramine is an amino acid that helps normalize blood pressure levels. It is formed during the breakdown of tyrosine in the human body, and can also be ingested from certain foods, such as:

moldy and hard cheeses; smoked or cured meats; soy products; beer.

MAOIs, often referred to as antidepressants, block an enzyme called monoamine oxidase, which helps break down excess tyramine. This, in turn, can cause an increase in blood pressure to a critical state.

But it remains unknown whether tyrosine can cause tyramine accumulation. Therefore, doctors strongly do not recommend using this supplement in combination with antidepressants.

Thyroid hormones

Substances such as thyroxine and triiodothyronine are the main thyroid hormones. They are responsible for metabolism and cell growth. Therefore, it is very important that the indicators of these hormones do not exceed the permissible value and are not below it.

Adding l-tyrosine to the diet may lead to an increase in thyroxine and triiodothyronine. This is due to the fact that this amino acid acts as a building material for the creation of thyroid hormones. For the same reason, individuals taking thyroid medication should be extremely careful when including tyrosine in their diet.

Levodopa

A drug called Levodopa is often prescribed to treat Parkinson’s disease. Its active components compete with tyrosine for absorption by the body in the small intestine, which can adversely affect the effectiveness of the drug. Therefore, doctors recommend taking tyrosine supplements 2 hours before or after taking the drug. At the same time, the researchers note that tyrosine is able to eliminate some of the symptoms of diseases associated with impaired cognitive functions.

Tyrosine Recommendations

form of the amino acid N-acetyl-L-tyrosine (NALT). This form of the substance is highly soluble in water, but is slowly absorbed. This means that the volumes of NALT used to meet the needs of the body must be higher than pure tyrosine.

In order to increase the effectiveness of training, the last form of the substance is recommended to be included in the diet in the amount of 500 to 2000 milligrams 30-60 minutes before the start of physical activity. To improve brain function, tyrosine should be taken in a ratio of 100 to 150 milligrams per 1 kilogram of its own weight.

Use of higher amounts of supplements may lead to gastrointestinal disturbances. Therefore, the recommended volume should be divided into two doses.

Conclusion

Tyrosine is a fairly popular dietary supplement that is used for a variety of purposes. It can be used to increase the amount of neurotransmitters that improve brain function in stressful situations, as well as to increase the effectiveness of certain drugs.

According to scientists, this supplement is absolutely safe. However, it may interact with some medications. Therefore, before including it in the diet, it is important to consult with your doctor.

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SOURCES

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738414/
• https://pubchem. ncbi.nlm.nih.gov/compound/L-tyrosine

L-Tyrosine Plus Caps Tyrosine plus 100 caps

• L-Tyrosine Plus Caps Tyrosine plus 100 caps

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L-Tyrosine Plus Caps Tyrosine plus 100 caps
Used by the body to synthesize a number of important biologically active substances.

Twinlab L-Tyrosine Plus is a high quality source of the amino acid L-Tyrosine, which plays a major role in a number of bodily functions.

Our body uses the amino acid L-tyrosine to synthesize proteins and create neurotransmitters – substances responsible for the formation of connections between neurons that affect sleep, mood and concentration, increase brain performance. Tyrosine is also involved in the production of melanin (the pigment that gives skin and hair their natural color).

• Fortified amino acid
• C Vitamin C and vitamin B6
• easy to use and assimilate

Taking L-Tyrosine increases the production of the neurotransmitters dopamine, norepinephrine and adrenaline, the thyroid hormones and the stress hormones norepinephrine.

Insufficiency of thyroid gland function results in decreased metabolism .
L-Tyrosine Plus is fortified with Vitamin C and Vitamin B6 to enhance absorption and maximize natural L-Tyrosine metabolism and utilization.
L-Tyrosine Plus is free of flavors, salt, artificial sweeteners, colors, preservatives and salicylates.

Serving Size: 2 Capsules

Total Servings: 50

Nutrient Content Per Serving :
Vitamin C 1000mg
Vitamin B6 100mg
L- tyrosine 500 mg

Other ingredients : gelatin , purified water, silica, MCT, magnesium.

Directions for Use: Take one TWINLAB® L-Tyrosine 500mg capsule daily, or as directed by your healthcare practitioner.

Well tolerated by most allergy sufferers. No flavors, salt, artificial sweeteners, colors, preservatives or salicylates.

Suggested Use: Take 1-2 capsules daily between meals on an empty stomach.