Lamisil Nail Treatment: Comprehensive Guide to Uses, Dosage, Side Effects, and Interactions

03.09.202329.06.2023 by alexxlab

What are the uses of Lamisil nail treatment. How should Lamisil be dosed for nail fungus. What are the common side effects of Lamisil. How does Lamisil interact with other medications. What warnings should be considered when using Lamisil nail treatment.

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Understanding Lamisil: A Powerful Antifungal Medication

Lamisil, also known by its generic name terbinafine, is a widely prescribed antifungal medication used to treat various fungal infections, particularly those affecting the nails. This potent medication works by preventing the growth of fungi, effectively eliminating the infection and promoting healthy nail growth.

How Does Lamisil Work?

Lamisil functions by inhibiting the enzyme squalene epoxidase, which is crucial for fungal cell membrane synthesis. By disrupting this process, Lamisil effectively kills the fungi causing the infection, allowing the nail to heal and grow normally.

Lamisil Nail Treatment: Indications and Uses

Lamisil is primarily used to treat fungal infections of the nails, a condition known as onychomycosis. This stubborn infection can affect both fingernails and toenails, causing discoloration, thickening, and brittleness of the nail plate.

Toenail fungus
Fingernail fungus
Athlete’s foot
Jock itch
Ringworm

Is Lamisil effective for all types of nail fungus? While Lamisil is highly effective against many fungal species, some infections may be resistant to treatment. In such cases, your healthcare provider may recommend alternative therapies or combination treatments.

Proper Dosage and Administration of Lamisil

The dosage and duration of Lamisil treatment depend on the severity of the infection and the specific formulation used. Lamisil is available in various forms, including oral tablets, topical creams, gels, and sprays.

Oral Lamisil Dosage

For nail infections, the typical dosage for adults is:

250 mg once daily for 6 weeks (fingernails)
250 mg once daily for 12 weeks (toenails)

How long does it take for Lamisil to show results? While the medication begins working immediately, visible improvement in nail appearance may take several months. Complete nail regrowth can take up to a year.

Topical Lamisil Application

For topical formulations, apply a thin layer to the affected area and surrounding skin:

Once or twice daily for cream or gel
Once daily for spray solution

Continue treatment as directed by your healthcare provider, typically for 1-2 weeks beyond symptom resolution.

Common Side Effects of Lamisil

Like all medications, Lamisil can cause side effects, although not everyone experiences them. Most side effects are mild and resolve on their own as your body adjusts to the medication.

Topical Lamisil Side Effects

The most common side effect of topical Lamisil formulations is:

Peeling or itching skin (occurs in more than 1 in 100 people)

To manage this side effect, try using smaller amounts of the medication or temporarily discontinue use. Avoid irritating fabrics and consider using an over-the-counter antihistamine for itching.

Oral Lamisil Side Effects

Common side effects of Lamisil tablets (occurring in more than 1 in 100 people) include:

Rash
Headache
Diarrhea
Nausea or vomiting
Decreased appetite
Taste disturbances
Stomach ache
Indigestion
Muscle or joint pain
Dizziness
Visual disturbances

How can you manage these side effects? Many of these symptoms can be alleviated with simple remedies:

For headaches, rest and stay hydrated. Use over-the-counter pain relievers if needed.
To combat nausea, take Lamisil with food and stick to simple, bland meals.
For diarrhea, drink plenty of fluids to prevent dehydration.
Manage indigestion by avoiding spicy, fatty foods and alcohol.

If side effects persist or worsen, consult your healthcare provider for advice.

Serious Side Effects and Warnings

While rare, Lamisil can cause serious side effects in some individuals. It’s crucial to be aware of these potential complications and seek immediate medical attention if they occur.

When to Seek Immediate Medical Care

Stop taking Lamisil and contact a healthcare professional immediately if you experience:

Yellowing of the eyes or skin (jaundice)
Pale stools with dark urine
Increased bruising or infections
High fever with rash, itching, and unusual fatigue
Purple spots under the skin
Severe upper abdominal pain radiating to the back

These symptoms may indicate serious conditions such as liver problems, blood disorders, or inflammation of blood vessels (vasculitis).

Lamisil Interactions: What You Need to Know

Lamisil can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all medications, supplements, and herbal products you’re taking.

Common Drug Interactions

Lamisil may interact with:

Certain antidepressants (e.g., tricyclic antidepressants, SSRIs)
Beta-blockers
Antiarrhythmic medications
Caffeine
Cimetidine
Rifampicin

How do these interactions affect treatment? Some interactions may increase the concentration of Lamisil in your blood, potentially enhancing both its therapeutic effects and side effects. Others may decrease its effectiveness, compromising treatment outcomes.

Maximizing Lamisil Treatment Efficacy

To ensure the best possible results from your Lamisil treatment, consider the following tips:

Take the medication exactly as prescribed, completing the full course of treatment.
For oral Lamisil, take it with food to minimize stomach upset.
Keep your nails clean and dry, and avoid walking barefoot in public areas.
Be patient – visible improvement may take several months.
Follow up with your healthcare provider regularly to monitor progress and potential side effects.

Can lifestyle changes improve Lamisil’s effectiveness? Yes, maintaining good foot hygiene, wearing breathable footwear, and managing underlying conditions like diabetes can contribute to better treatment outcomes.

Alternative Treatments for Nail Fungus

While Lamisil is highly effective, some patients may seek alternatives due to contraindications, side effects, or personal preference. Several other options are available for treating nail fungus:

Other oral antifungals (e.g., itraconazole, fluconazole)
Topical antifungal nail lacquers
Laser therapy
Photodynamic therapy
Natural remedies (e.g., tea tree oil, vinegar soaks)

How do these alternatives compare to Lamisil? While some may be effective for mild cases or as adjunct therapies, Lamisil remains one of the most potent treatments for nail fungus, particularly for moderate to severe infections.

Long-Term Nail Health: Prevention and Maintenance

After successfully treating a nail fungus infection with Lamisil, it’s important to maintain healthy nails to prevent recurrence. Consider these preventive measures:

Keep nails short, clean, and dry
Wear breathable footwear and moisture-wicking socks
Use antifungal powder in shoes
Avoid walking barefoot in public areas like pools and locker rooms
Don’t share nail care tools
Choose nail salons that properly sterilize their equipment

Is it possible to prevent nail fungus entirely? While complete prevention isn’t always possible, these measures significantly reduce your risk of infection or reinfection.

Monitoring for Recurrence

Even after successful treatment, it’s crucial to monitor your nails for any signs of reinfection. Early detection and prompt treatment can prevent the fungus from reestablishing itself.

How often should you inspect your nails? Regularly examine your nails, ideally weekly, for any changes in color, texture, or thickness. If you notice any concerning symptoms, consult your healthcare provider promptly.

Special Considerations for Lamisil Use

Certain groups of people may need to take extra precautions when using Lamisil or may not be suitable candidates for this medication.

Pregnancy and Breastfeeding

Lamisil is generally not recommended during pregnancy or while breastfeeding unless the potential benefits outweigh the risks. Limited data is available on its effects on fetal development and infants.

Elderly Patients

Older adults may be more sensitive to the side effects of Lamisil, particularly liver-related complications. Closer monitoring may be necessary for this population.

Patients with Liver or Kidney Disease

Individuals with pre-existing liver or kidney conditions may require dose adjustments or alternative treatments. Regular liver function tests are often recommended during Lamisil therapy.

How does liver function affect Lamisil treatment? The liver plays a crucial role in metabolizing Lamisil. Impaired liver function can lead to higher blood levels of the medication, potentially increasing the risk of side effects.

The Future of Nail Fungus Treatment

As research in dermatology and mycology progresses, new treatments for nail fungus are continually being developed and tested. Some promising areas of research include:

Novel antifungal compounds with improved efficacy and safety profiles
Combination therapies that target multiple aspects of fungal growth
Nanotechnology-based delivery systems for improved drug penetration
Immunotherapies that enhance the body’s natural defenses against fungal infections

Will these advancements replace Lamisil in the future? While new treatments may offer additional options, Lamisil is likely to remain a valuable tool in the treatment of nail fungus due to its proven efficacy and well-established safety profile.

Ongoing Research and Clinical Trials

Numerous clinical trials are underway to explore new treatments and improve existing ones. Patients interested in participating in these studies can find information through their healthcare providers or reputable clinical trial databases.

How can participating in clinical trials benefit patients? Clinical trials offer access to cutting-edge treatments and contribute to the advancement of medical knowledge, potentially benefiting future patients with nail fungus.

Side effects of terbinafine – NHS

Like all medicines, terbinafine can cause side effects, although not everyone gets them.

Side effects usually go away when you stop using or taking the medicine.

Common side effects

This common side effect of terbinafine cream, gel, spray or solution happens in more than 1 in 100 people. There are things you can do to help cope:

Peeling or itching skin

If you’re using the cream, gel or spray, try using smaller amounts or stop using it completely. Avoid clothes that irritate your skin, such as wool or synthetic fabrics. If the rash is itchy, pat or tap the area rather than scratching.

It may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.

These common side effects of terbinafine tablets happen in more than 1 in 100 people. There are things you can do to help cope with them:

Rash

Avoid clothes that irritate your skin, such as wool or synthetic fabrics. If the rash is itchy, pat or tap the area rather than scratching.

It may help to take an antihistamine, which you can buy from a pharmacy. Check with the pharmacist to see what type is suitable for you.

Headache

Rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller if you need one.

Talk to your doctor if the headaches last longer than a week or are severe.

Diarrhoea

Drink lots of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.

If you take contraceptive pills and you have severe diarrhoea for more than 24 hours, your contraception may not protect you from pregnancy. Check the pill packet for advice.

Feeling or being sick (nausea or vomiting)

Stick to simple meals and do not eat rich or spicy food. If you’re being sick, try small, frequent sips of water to avoid dehydration. It might help to take your tablets after a meal or snack.

If you take contraceptive pills and you’re being sick, your contraception may not protect you from pregnancy. Check the pill packet for advice.

A smaller appetite than usual

Your appetite should get better as your body gets used to the medicine. It may also help to eat smaller and more frequent meals and to eat foods you really enjoy.

If your appetite does not improve or you lose a lot of weight, ask your doctor for advice.

Losing your sense of taste

This usually gets better gradually after you stop taking terbinafine. Speak to a doctor if it does not get better.

Stomach ache

It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help.

If you’re in a lot of pain, speak to a doctor or pharmacist.

Indigestion

Try not to drink too much alcohol or drinks containing caffeine, such as tea, coffee, cola or energy drinks. Avoid rich, spicy or fatty foods.

If indigestion bothers you mostly at night, stop eating 3 to 4 hours before your bedtime, and try propping your head and shoulders up in bed.

Ask a pharmacist to recommend an antacid.

Muscle or joint pain

Ask a pharmacist to recommend a painkiller if you need one. Talk to your doctor if the pain lasts longer than a week or is severe.

Feeling dizzy

Stop what you’re doing and sit or lie down until you feel better. Do not drive, cycle or use tools or machinery if you’re feeling dizzy.

Problems with your eyesight

Talk to your doctor if this bothers you.

Talk to your pharmacist or doctor if the advice on how to cope does not help and these side effects bother you or do not go away.

Serious side effects

Some people can have serious side effects when using or taking terbinafine. These happen in less than 1 in 1,000 people.

If you’re prescribed tablets, stop taking them and call a doctor or contact 111 immediately if:

the whites of your eyes turn yellow, or your skin turns yellow although this may be less obvious on brown or black skin, or if you have pale poo and dark pee – these can be signs of liver problems
you bruise more easily or get infections more easily – these can be signs of a blood disorder
you have a high temperature with a rash, itchy skin and unusual tiredness, or if you notice any purple spots under your skin – these can be signs of an inflammation of the blood vessels called vasculitis
you get severe pain near the top of your stomach that spreads to your back – this can be a sign of an inflamed pancreas (acute pancreatitis)
your muscles feel weak or painful, or your pee is a dark red-brown – these can be signs of muscle problems

Go to 111. nhs.uk or call 111. Call 111 if you need advice for a child under the age of 5 years.

Serious allergic reaction

It happens rarely but it is possible to have a serious allergic reaction (anaphylaxis) to terbinafine.

Immediate action required: Call 999 or go to A&E now if:

you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
you’re wheezing
you get tightness in the chest or throat
you have trouble breathing or talking
your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

Long-term side effects

If you take terbinafine tablets for a long time, there’s a small chance that they can affect your liver. This happens to less than 1 in 1,000 people. Your doctor may ask you to have a blood test to check that your liver is working properly.

Other side effects

These are not all the side effects of terbinafine. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 24 March 2023

Next review due: 24 March 2026

Lamisil (Terbinafine Hydrochloride)

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Description

Details

Lamisil Description

Lamisil or generic Terbinafine is a popular prescription medication that is taken orally to kill fingernail and toenail fungal infections called onychomycosis. This fungus thrives on a rich blood supply in your nail bed beneath the protection of your nail and causes your nails to become discolored, brittle, and very unappealing to look at. The generic alternative is not manufactured by the company that makes the brand product.

The fungus looks for warm, moist areas to start growing and multiplying, and your toes are the ideal spot. A crack or small cut in your skin is all it takes. Without treatment, the fungus can spread to your other nails and cause discomfort as well as embarrassment. The treatment period can take as long as three months for toenail fungus and six weeks for fingernail fungus.

How Lamisil Interferes with Fungal Growth

Once taken as directed, Lamisil finds its way through your bloodstream and zeros in on the fungal cell membranes, which are essential for their survival. By interfering with the fungi’s ability to produce an important component of the cell membranes, called ergosterol, the stability of the cell membranes is impaired and holes begin to appear. This allows substances to leak out while other substances seep in and destroy the membranes so the fungi cannot multiply and they will die off. This is why it’s important to take Lamisil for the specified time recommended so the fungi will not start up again.

Risk Factors That Raise the Possibility of a Fungal Infection

There are fungi present in and on your body that co-exist with bacteria and do no harm for the most part. You don’t even know they are there, at least not until you have a scratch, scrape, or abrasion somewhere that allows these roommates to enter and begin reproducing. There are very few health conditions or diseases that affect our nails and fungal infections are the most common.

A manicure or pedicure at a salon that pays little attention to disinfecting their tools of the trade can spread fungal infections from one person to another. Jobs that involve long hours of wearing rubber boots or gloves provide the perfect damp, warm environment for fungi to settle into. Other risk factors for developing a fungal nail infection are; being diabetic, over 65 years old with poor circulation, wearing artificial nails, sustaining a nail injury, or a skin injury around the nail.

Before You Take Lamisil

Ask your doctor if it is harmful to take Lamisil while you are pregnant, become pregnant during treatment, or if you are nursing your baby. Discuss your medical history with your doctor and provide information on any OTC or Rx drugs you are taking, including herbal remedies and vitamin or dietary supplements. This can help determine if Lamisil is the right medication for you.

Lamisil Precautions and Proper Use

Lamisil may make your skin more sensitive to sunlight, so you should avoid tanning beds and use sunscreen that is at least an SPF30 or higher and protective clothing when you are outside. After your treatment time has been completed, it may still take several months for your nails to return to their usual appearance, so be patient. Avoid sharing foot wear, gloves or manicure tools with others until your infection has cleared.

Possible Side Effects of Lamisil

Headache

Diarrhea

Changes in sense of taste or smell

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Memo for foot care in diabetes – Aspasia

Wash your feet daily with lukewarm water, then pat them dry with a soft towel, paying attention to the spaces between the toes. The increased humidity of these areas contributes to the development of diaper rash and fungal skin lesions.

In the presence of keratinized skin, corns, treat such areas with a pumice stone. You should use it while washing your feet and do not try to remove corns at a time. Never use a blade, corn plaster, keratolytics or scissors for this purpose.

If your feet are dry, after washing, lubricate them with bold foot cream, excluding the areas between the toes. This prevents the formation of cracks, a possible entrance gate of infection.

Handle nails very carefully – cut them straight without rounding the corners, but rather file them with a nail file. Cutting the corners of the nail or filing it too round can lead to the formation of an ingrown nail, which causes pain and inflammation.

Inspect feet and toes daily for damage, cracks, and abrasions. It is convenient to inspect the sole with a mirror placed on the floor.

Change socks and stockings daily. It is necessary to ensure that the socks do not go astray in the shoes and do not have tight elastic bands.

To warm your feet, use warm socks without tight elastic bands, and not a heating pad, radiator or hot water (above 40 degrees), as due to reduced sensitivity, you can get burned. In addition, foot baths should not be long, as this loosens the skin and makes it more vulnerable.

Inspect shoes daily for foreign matter, insoles curled up, nails protruding. All this can lead to abrasion and damage to the skin of the feet, which should not be allowed.

Never go barefoot (even at home), and never wear shoes with bare feet.

Choose the right shoes in the store. Do not buy hard, narrow shoes, shoes with heels. With decreased sensitivity – go shopping with a cardboard imprint of your foot (cardboard insole). You need to be careful with new shoes: for the first time, put them on for no more than one hour and in no case use methods such as breaking in with a wet sock. Do not wear open shoes or strappy shoes.

Do daily vascular exercises for the legs and feet.

Lace your shoes correctly – the lacing should be parallel.

In the presence of a fungal infection of the nails or skin of the feet, it is necessary to use special antimycotic agents (Nitrofungin, Clotrimazole, Lamisil, Loceryl, etc.).

In case of damage to the skin (crack, scratch, cut, abrasions), use colorless antiseptic solutions for processing (Miramistin, Dioxidine 1%, Chlorhexidine). The washed wound should be closed with a sterile bandage or a bactericidal adhesive plaster (you cannot use a regular adhesive plaster!). Do not use alcohol solutions (iodine, brilliant green), as well as a concentrated solution of potassium permanganate.