Can lactose intolerance develop as you age. What are the signs of late-onset lactose intolerance. How can you manage lactose intolerance in adulthood. What dietary changes are necessary for lactose intolerance.

Understanding Late-Onset Lactose Intolerance

Lactose intolerance is a condition characterized by the inability to digest lactose, the primary sugar found in dairy products. While many people associate this condition with childhood or genetic predisposition, it’s possible to develop lactose intolerance later in life, a phenomenon known as late-onset lactose intolerance.

What causes late-onset lactose intolerance? The primary factor is a decrease in the production of lactase, the enzyme responsible for breaking down lactose. As Laura Acosta, a registered dietitian at the University of Florida, explains, “Some people are able to tolerate lactose throughout their lives, but others become more lactose intolerant as they age, usually caused by their genes.”

The Prevalence of Late-Onset Lactose Intolerance

How common is late-onset lactose intolerance? According to Dr. Vijaya Surampudi, assistant professor of medicine at the University of California, Los Angeles, “About 65% of people may experience lactose intolerance at some point in their lives.” This high prevalence underscores the importance of understanding the condition and its management.

Recognizing the Symptoms of Late-Onset Lactose Intolerance

Identifying late-onset lactose intolerance can be challenging, as symptoms may develop gradually over time. What are the telltale signs of this condition?

• Gas and bloating
• Abdominal discomfort
• Diarrhea
• Nausea

These symptoms typically occur 30 minutes to 2 hours after consuming dairy products. It’s important to note that the severity of symptoms can vary greatly among individuals, with some experiencing mild discomfort and others facing more severe reactions.

Factors Contributing to Late-Onset Lactose Intolerance

While aging is a primary factor in the development of late-onset lactose intolerance, several other conditions can contribute to its onset. Dr. Christine Lee, a gastroenterologist at Cleveland Clinic, points out that “you can also become lactose intolerant if you have an illness, infection, or take a medication that affects the bowels or intestines.”

Medical Conditions Associated with Late-Onset Lactose Intolerance

What medical conditions are linked to the development of lactose intolerance in adulthood?

1. Crohn’s disease
2. Ulcerative colitis (UC)
3. Celiac disease
4. Injury or trauma to the small intestines

These conditions can damage the intestinal lining or alter gut function, potentially leading to lactose intolerance. It’s crucial to consult with a healthcare provider if you suspect an underlying condition is causing your symptoms.

Dietary Sources of Lactose: What to Watch Out For

Managing late-onset lactose intolerance requires a thorough understanding of dietary sources of lactose. What foods and ingredients should individuals with lactose intolerance be cautious about?

• Milk and milk-based products
• Cheese and cheese spreads
• Whey and milk by-products
• Ice cream and heavy cream
• Yogurt
• Butter and curds

It’s important to note that lactose can be found in unexpected places. Many processed foods, baked goods, and even some medications may contain lactose. Always check ingredient labels carefully, and be aware of terms like “milk solids” or “whey protein” that indicate the presence of lactose.

Strategies for Managing Late-Onset Lactose Intolerance

Developing lactose intolerance later in life doesn’t necessarily mean you must completely eliminate dairy from your diet. What strategies can help manage this condition?

Gradual Reduction and Experimentation

Some individuals with lactose intolerance may be able to tolerate small amounts of dairy or specific types of dairy products. As Laura Acosta suggests, “Cheese actually has very little lactose. In general, the harder the cheese, the less lactose it has. So many people with lactose intolerance can still tolerate cheese like Parmesan and Swiss in small amounts.”

Lactase Supplements

For those who wish to continue consuming dairy, lactase supplements can be a helpful tool. These over-the-counter enzymes, taken before consuming dairy, can aid in lactose digestion. Dr. Lee recommends, “You can choose to take lactase tablets or drops, enzymes sold in most grocery stores without a prescription, or buy lactose-free milk products.”

Lactose-Free Alternatives

The market for lactose-free dairy products has expanded significantly in recent years. Many grocery stores now offer lactose-free milk, cheese, and yogurt options that allow individuals to enjoy dairy without the digestive discomfort.

Nutritional Considerations for Late-Onset Lactose Intolerance

One of the primary concerns for individuals developing lactose intolerance later in life is maintaining adequate calcium intake. How can you ensure you’re meeting your nutritional needs while managing lactose intolerance?

Non-Dairy Calcium Sources

Allie Wergin, a registered dietitian/nutritionist with Mayo Clinic Health System, emphasizes the importance of finding alternative calcium sources: “There are many calcium-rich foods people can eat if they’re avoiding lactose.” These include:

• Leafy green vegetables (e.g., kale, spinach, collard greens)
• Fortified plant-based milk alternatives (e.g., almond milk, soy milk)
• Calcium-fortified orange juice
• Canned fish with soft bones (e.g., sardines, salmon)
• Nuts and seeds (e.g., almonds, sesame seeds)

Incorporating these foods into your diet can help ensure you’re meeting your calcium needs even without dairy products.

Vitamin D Consideration

Vitamin D plays a crucial role in calcium absorption. Many dairy products are fortified with vitamin D, so individuals avoiding dairy should be mindful of their vitamin D intake. Consider discussing vitamin D supplementation with your healthcare provider, especially if you have limited sun exposure.

When to Seek Medical Advice for Late-Onset Lactose Intolerance

While lactose intolerance is generally not a serious health condition, it’s important to know when to consult a healthcare professional. What symptoms warrant medical attention?

• Unexplained weight loss
• Blood in stool
• Anemia
• Persistent nausea or vomiting
• Severe abdominal pain

Dr. Lee emphasizes, “Always play it safe and discuss your symptoms with your physician.” These symptoms may indicate a more serious underlying condition that requires medical intervention.

The Future of Late-Onset Lactose Intolerance Management

As our understanding of gut health and digestive processes continues to evolve, what does the future hold for managing late-onset lactose intolerance?

Advancements in Enzyme Replacement Therapy

Research is ongoing to develop more effective and longer-lasting lactase supplements. These advancements could potentially allow individuals with lactose intolerance to consume dairy products with greater ease and less frequent supplement use.

Gut Microbiome Modulation

Emerging research suggests that the gut microbiome plays a role in lactose tolerance. Future treatments may focus on modulating the gut microbiome to improve lactose digestion naturally.

Personalized Nutrition Approaches

As the field of nutrigenomics advances, we may see more personalized approaches to managing lactose intolerance based on an individual’s genetic profile and specific lactase production patterns.

Late-onset lactose intolerance, while potentially challenging, is a manageable condition. By understanding its causes, recognizing symptoms, and implementing appropriate dietary and lifestyle changes, individuals can effectively navigate this dietary shift. Remember, the key to successful management lies in personalized approaches and open communication with healthcare providers.

As research in this field continues to advance, we can expect even more sophisticated and tailored strategies for managing late-onset lactose intolerance in the future. This ongoing progress offers hope for improved quality of life for those affected by this common digestive condition.

Can You Get It as You Get Older?

Written by Susan Bernstein

Do you get gas, bloating, or even diarrhea after you eat dairy foods? You may be lactose intolerant. This is when you can’t digest lactose, the type of sugar found in dairy products.

Lactose intolerance isn’t a serious health condition, but symptoms can be uncomfortable. You may have stomach upset or gas about 30 minutes to 2 hours after you eat or drink any dairy food.

Lactose intolerance is caused by low levels of lactase, an enzyme that helps you digest lactose in dairy foods, says Laura Acosta, a registered dietitian at the University of Florida in Gainesville.

“Some people are able to tolerate lactose throughout their lives, but others become more lactose intolerant as they age,” usually caused by your genes, she says. “Some people stop producing lactase, or produce less of it, as they reach adulthood and beyond.”

Lactose intolerance is more common among people of Southeast Asian, East Asian, West African, Native American, Hispanic, or Italian ancestry because they’re more likely to carry the gene mutation that causes the condition, says Vijaya Surampudi, MD, assistant professor of medicine at the University of California, Los Angeles.

“We have the highest amounts of lactase when we are young because as babies, we feed on milk. But we often make less and less lactase as we age,” she says. “About 65% of people may experience lactose intolerance at some point in their lives.”

There’s a wide range of lactose intolerance, with some people having no tolerance for dairy, while others can manage to digest foods like hard cheeses or yogurt, she says.

It’s fairly common to notice the signs of lactose intolerance appear as you get older, says Christine Lee, MD, a gastroenterologist at Cleveland Clinic in Ohio.

“This enzyme production can decrease over time in some people, so most people can experience some degree of lactose intolerance as they get older,” Lee says. You can also become lactose intolerant if you have an illness, infection, or take a medication that affects the bowels or intestines.

These conditions can also cause you to develop lactose intolerance later in life:

• Crohn’s disease
• Ulcerative colitis (UC)
• Celiac disease
• Injury or trauma to your small intestines

Foods. Any dairy foods or drinks can have lactose, so read food labels carefully. These foods or ingredients may trigger symptoms:

• Cheese
• Whey
• Milk by-products
• Dry milk
• Butter
• Curds
• Ice cream
• Heavy cream
• Cottage cheese
• Cheese spreads
• Yogurt

Look for milk in ingredients lists in baked goods, chocolate candies, sauces, instant mashed potatoes, pancakes, or milk-based meal replacement or protein shakes. Even non-dairy coffee creamer or whipped toppings may contain some lactose.

Medications. Some medications like birth control pills or antacid tablets also contain lactose, but these may only cause symptoms in people with severe lactose intolerance. Check the labels of your prescription or OTC medications to see if they contain lactose. Ask your doctor or pharmacist if it’s OK for you to take them.

You may not have to give up all the dairy foods you enjoy if you develop lactose intolerance.

Some people with lactose intolerance may be able to eat or drink small amounts of dairy or switch to skim milk and have fewer symptoms. Some people can eat yogurt because it contains live bacteria cultures that help you produce the lactase enzyme to break down lactose.

“Cheese actually has very little lactose. In general, the harder the cheese, the less lactose it has. So many people with lactose intolerance can still tolerate cheese like Parmesan and Swiss in small amounts. This depends on an individual’s sensitivity,” Acosta says.

Talk to your doctor to identify what’s causing your lactose intolerance so you can make the right changes to your diet, Lee says.

“If it’s due to decreased production of lactase, then you can choose to take lactase tablets or drops, enzymes sold in most grocery stores without a prescription, or buy lactose-free milk products,” she says. Supplements are taken before a meal with dairy to help you digest the lactose.

If your lactose intolerance is due to a bowel disease or other health conditions, treat that illness first, she adds. “Always play it safe and discuss your symptoms with your physician.” Unexplained weight loss, bleeding, anemia, nausea, or vomiting may be signs of a more serious medical condition, not just lactose intolerance, she says.

As you age, you still need to get enough calcium even if you develop lactose intolerance. Calcium helps you maintain strong bones and teeth, and healthy muscles and nerves.

“There are many calcium-rich foods people can eat if they’re avoiding lactose,” says Allie Wergin, a registered dietitian/nutritionist with Mayo Clinic Health System. “These include lactose-free dairy products like Lactaid or Dairy Ease milks, where the lactose is predigested or hydrolyzed. This means the milk protein has already been broken down and is easier to digest.”

Other foods that are good sources of calcium, according to Wergin:

• Calcium-fortified cereals and fruit juices
• Tofu prepared using calcium sulfate
• Canned salmon or sardines with bones
• Plant-based soy, almond, oat, or rice milks
• Leafy green vegetables like spinach, kale, bok choy, or collard greens
• Broccoli
• Almonds
• Beans like garbanzo, kidney, or navy

“We recommend that you get calcium through your diet. There are different calcium supplements, including calcium carbonate, which is best absorbed if you take it with food, and calcium citrate, which you can take with or without food,” Surampudi says. Only take a calcium supplement if your doctor says you need one, she says.

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Mayo Clinic Q and A: Lactose Intolerance Can Develop at Any Age

• By

  Liza Torborg

  June 14, 2016

DEAR MAYO CLINIC: What would cause someone to become lactose-intolerant later in life? I’m in my 40s and have never had an issue with dairy, but, now, I can’t seem to have it without problems. Do I need to see a doctor to be tested for allergies, or should I just avoid dairy?

ANSWER: Lactose intolerance isn’t a true allergy, and it can develop at any age. In some people, lactose intolerance may be triggered by another medical condition, such as Crohn’s disease. In others, it develops without a specific underlying cause. It would be a good idea to have your condition evaluated by your doctor to confirm that what you’re dealing with truly is lactose intolerance.

Lactose intolerance results from a problem with the carbohydrate lactose, a type of sugar found in dairy products. When you eat or drink dairy products, enzymes in your small intestine digest lactose, so the body can make energy. In people with lactose intolerance, a certain enzyme, called lactase, is missing from the body. When those people eat dairy products, the body has no way to break down the lactose. This leads to fermentation of the sugar in the intestines and triggers symptoms, such as diarrhea, nausea, abdominal cramps, bloating and gas.

Sometimes, lactose intolerance develops when the small intestine’s production of lactase decreases after an illness, injury or surgery involving the small intestine. This is called secondary lactose intolerance. Among the diseases associated with this kind of lactose intolerance are celiac disease, bacterial overgrowth and Crohn’s disease. Treatment of the underlying disorder may restore lactase levels and improve symptoms.

More common than secondary lactose intolerance is primary lactose intolerance. People who develop primary lactose intolerance start life making normal levels of lactase — a necessity for infants, who get all their nutrition from milk. As children replace milk with other foods, lactase production normally decreases. It stays high enough, though, to digest the amount of dairy in a typical adult diet. In primary lactose intolerance, lactase production declines below normal at some point for reasons that are unclear. The low amount of lactase then makes milk products difficult to digest and leads to lactose intolerance symptoms.

Your doctor can confirm a diagnosis of lactose intolerance with a clinical test. One that’s often used is a lactose tolerance test. It assesses your body’s reaction to a dose of lactose. After you consume a drink containing lactose, a sample of your blood is taken to measure glucose levels. If your glucose level does not rise, it means your body isn’t properly digesting and absorbing the lactose.

Alternatively, another test called the hydrogen breath test may be used. This test also requires you to consume a drink that contains high levels of lactose. Your doctor next measures the amount of hydrogen in your breath. Normally, very little hydrogen is detectable. However, if your body doesn’t digest the lactose, the fermentation reaction in your colon releases hydrogen and other gases. Your intestines absorb those gases, and you exhale them. Larger-than-normal amounts of hydrogen measured during this test are a sign that your body isn’t fully digesting and absorbing lactose.

If you have lactose intolerance, there isn’t a way to cure it. The most effective way for people with lactose intolerance to get relief from symptoms is to lower the amount of dairy products they eat. You may be able to use dairy products that have reduced levels of lactose or are lactose-free. Some people who have lactose intolerance benefit from taking lactase enzyme supplements, as well.

If test results do not point to lactose intolerance, your doctor may recommend additional tests to check for another condition that could be causing your symptoms, such as a milk allergy, intestinal disorders or other problems within your digestive tract. — Dr. Rohit Divekar, Allergic Diseases, Mayo Clinic, Rochester, Minnesota

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Lactose intolerance | Symptoms, complications, diagnosis and treatment

People with lactose intolerance are unable to fully digest the lactose in milk. As a result, they develop diarrhea, gas, and bloating after eating or consuming dairy products. The condition, also called lactose malabsorption, is usually harmless, but its symptoms can be uncomfortable. Most people with lactose intolerance can manage the condition without giving up all dairy products.

Lactase deficiency, an enzyme produced in the small intestine, is usually responsible for lactose intolerance. Many people have low lactase levels but can digest dairy products without problems. If you are actually lactose intolerant, lactase deficiency leads to symptoms after you eat dairy products.

Signs and symptoms of lactose intolerance usually begin 30 minutes to two hours after eating or drinking foods containing lactose. General signs and symptoms include:

• Diarrhea
• Nausea and sometimes vomiting
• Abdominal cramps
• Inflate
• Gases

Make an appointment with your doctor if you often experience symptoms of lactose intolerance after eating dairy products, especially if you are worried about getting enough calcium.

Reasons

Lactose intolerance occurs when the small intestine does not produce enough enzyme (lactase) to digest milk sugar (lactose).

Normally, lactase converts milk sugar into two simple sugars, glucose and galactose, which are absorbed into the bloodstream through the intestinal lining.

If you are lactase deficient, the lactose in food moves to the large intestine instead of being processed and absorbed. In the colon, normal bacteria interact with undigested lactose, causing the signs and symptoms of lactose intolerance.

There are three types of lactose intolerance. Various factors cause lactase deficiency underlying each type.

Primary lactose intolerance

This is the most common type of lactose intolerance. People with primary lactose intolerance begin their lives by producing large amounts of lactase, a must for babies who get all their nutrients from milk. As children replace milk with other foods, their lactase production usually decreases but remains high enough to digest the amount of dairy in a normal adult diet.

In primary lactose intolerance, lactase production drops dramatically, making it difficult for adults to digest dairy products. Primary lactose intolerance is genetically determined, which occurs in a significant proportion of people of African, Asian, or Hispanic ancestry. This condition is also common among Mediterranean or South European ancestry.

Secondary lactose intolerance

This form of lactose intolerance occurs when the small intestine reduces its production of lactase after illness, injury, or surgery involving the small intestine. Diseases associated with secondary lactose intolerance include celiac disease, bacterial overgrowth, and Crohn’s disease. Treating the underlying disorder can restore lactase levels and improve symptoms and signs, although this may take some time.

Congenital or developing lactose intolerance

This disorder is passed from generation to generation in a form of inheritance called autosomal recessive. Premature babies may also be lactose intolerant due to insufficient lactase levels.

Factors that may make you or your child more likely to become lactose intolerant, include:

• Growing up. Lactose intolerance usually appears in adulthood. This disease is rare in children and young children.
• Ethnos. Lactose intolerance is most common in African, Asian, Hispanic, and American Indian people.
• Premature birth. Babies born prematurely may have low lactase levels because the small intestine does not develop lactase-producing cells until late in the third trimester.
• Diseases affecting the small intestine. Small intestinal problems that can cause lactose intolerance include bacterial overgrowth, celiac disease, and Crohn’s disease.
• Some treatments for cancer. If you’ve had radiation therapy for abdominal cancer or intestinal complications from chemotherapy, you’re at increased risk of lactose intolerance.

Lactase deficiency in adults

Lactase deficiency is a violation of the breakdown of lactose due to a deficiency of the lactase enzyme of the small intestine mucosa, accompanied by clinical symptoms.

Lactose is milk sugar. The enzyme that breaks down lactose is called lactase.

Adult-type lactase deficiency develops after a period of breastfeeding. This is due to a gradual decrease in lactase activity with age. After taking dairy products or whole milk, intestinal disorders (diarrhea, flatulence) usually appear. Prevention and treatment consists of following a low-lactose diet or eliminating it completely.

Russian synonyms

Congenital adult lactase deficiency (delayed onset type), primary adult lactase deficiency, hypolactasia, lactose intolerance, lactose malabsorption.

English synonyms

#OMIM 223100, Lactose intolerance, adult type, Hypolactasia, adult type, Disaccharide intolerance III.

Symptoms

Lactase deficiency is characterized by the development of intestinal symptoms after taking milk and dairy products: flatulence, pain and rumbling in the abdomen, diarrhea, bloating. Possible nausea. The stool is liquid or mushy, light yellow in color, with a sour smell.

General information about the disease

Lactase deficiency, or primary lactase deficiency, is a violation of the breakdown of lactose due to a deficiency of the lactase enzyme of the small intestine mucosa, accompanied by clinical symptoms. It is caused by a genetically determined decrease in its production, which manifests itself in the inability to absorb milk sugar (lactose).

Lactase activity manifests itself from the 12-14th week of intrauterine development and reaches its maximum values ​​by the time of birth (at the time of 39-40 weeks). After birth, lactase is produced in large quantities, but by the end of the first year of life, its production decreases. This is the primary, or congenital, late-onset lactase deficiency, which is inherited in an autosomal recessive manner.

Non-specific abdominal symptoms (bloating, upset stool, nausea) develop after consumption of foods containing lactose, mainly whole milk and dairy products. But today lactose is added to other foods (for example, meat, confectionery). The pharmaceutical industry also uses it as an excipient.

The severity of hypolactasia symptoms depends on individual physiological characteristics of a person, intestinal microflora, diet, and psychological factors. Conscious avoidance of milk, which is an important source of calcium, can lead to a deficiency of this element and, as a result, to osteoporosis. This should be remembered and compensate for the daily requirement through other foods rich in calcium. This is especially important for postmenopausal women.

Primary lactase deficiency should be distinguished from secondary (acquired), which occurs when the mucous membrane of the small intestine is damaged due to any acute or chronic disease. Such damage is possible with infectious (intestinal infection), immune (intolerance to cow’s milk protein), inflammatory processes in the intestine, atrophic changes (with celiac disease, after a long period of complete parenteral nutrition, etc.).

Also, this disorder should not be confused with congenital lactase deficiency, a rare genetic disorder whose symptoms appear immediately after birth and are associated with the onset of breastfeeding.

There is a genetic diagnosis of late-onset primary lactase deficiency. The MCM6 gene region is one of the important regulatory elements of the lactase gene. The genetic marker MCM6 (C(-13910)T) is associated with lactose intolerance.

Who is at risk?

• Persons with relatives who are intolerant to milk and dairy products.
• Certain ethnic groups. Lactose intolerance is most common in North America, Africa, Southeast Asia (the incidence of lactase deficiency is 70-100%) In the Russian population, lactase deficiency is observed in approximately 16%.
• The condition rarely occurs in the first year of life, the development of lactose intolerance is associated with growing up.

Diagnosis

The diagnosis can be assumed on the basis of genealogical data, results of coprology (increase in starch, fiber, iodophilic microflora, decrease in fecal pH less than 5.5), determination of carbohydrates in feces. The diagnosis uses a hydrogen breath test. The concentration of hydrogen in the exhaled air is determined before and after lactose loading. In patients with lactase deficiency, an increase in the hydrogen content is recorded, which is associated with increased bacterial breakdown of lactose in the colon. That is, lactose, not completely absorbed in the small intestine, reaches the large intestine, where it is broken down by anaerobic microflora.

Important in the diagnosis is molecular genetic testing for predisposition to lactase deficiency. The analysis will help in the differential diagnosis of the causes of lactose malabsorption and in the selection of an appropriate diet.

With severe clinical manifestations, refusal of milk, it is also important to determine the calcium content in the blood serum and urine.

Treatment

Diet therapy: restriction of products containing lactose.

It is possible to prescribe enzyme preparations that break down lactose.

It is allowed to use fermented milk products with a reduced amount of lactose (yogurt, curdled milk), cottage cheese, butter, hard cheeses, as well as lactose-free.

It is important to take into account the possible lack of calcium intake on a dairy-free diet, which is recommended to be compensated by other foods rich in it or medications.

In young children, often lactase deficiency is combined with intolerance to cow’s milk proteins.