What are the main uses of Linezolid 600mg. How does Linezolid work against bacterial infections. What are the common side effects of Linezolid 600mg. How should patients take Linezolid oral medication. What dietary restrictions are necessary while taking Linezolid. What serious side effects should patients watch out for when using Linezolid.

Understanding Linezolid: A Powerful Antibiotic

Linezolid is a potent antibiotic used to combat serious bacterial infections. As a member of the oxazolidinone class of antibiotics, it works by inhibiting bacterial protein synthesis, effectively halting the growth and reproduction of harmful bacteria. This medication is particularly valuable in treating infections caused by resistant strains of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).

Why is Linezolid prescribed? Doctors typically prescribe Linezolid when other antibiotics have proven ineffective or when patients are allergic to alternative treatments. It’s crucial to understand that Linezolid is not a cure-all for every infection. It specifically targets bacterial infections and will not be effective against viral illnesses such as the common cold or flu.

Key Points About Linezolid’s Mechanism of Action

• Inhibits bacterial protein synthesis
• Effective against resistant bacterial strains
• Not suitable for viral infections
• Belongs to the oxazolidinone class of antibiotics

Dosage and Administration of Linezolid 600mg

The standard dosage for Linezolid is 600mg, typically administered every 12 hours. However, the exact dosing schedule may vary based on the patient’s age, weight, and the specific infection being treated. For pediatric patients, the dosage is carefully calculated based on body weight, and in some cases, may be administered every 8 hours instead of 12.

How should patients take Linezolid? This medication can be taken with or without food, providing flexibility for patients with varying dietary habits or restrictions. It’s crucial to take Linezolid at evenly spaced intervals to maintain a consistent level of the drug in the body, maximizing its effectiveness against the infection.

Guidelines for Taking Linezolid

1. Take at the same time(s) each day
2. Complete the full prescribed course, even if symptoms improve
3. Do not skip doses or stop treatment early without consulting a doctor
4. If a dose is missed, take it as soon as remembered, unless it’s close to the next scheduled dose

Dietary Restrictions and Interactions with Linezolid

One of the unique aspects of Linezolid treatment is the necessity for dietary restrictions. Linezolid acts as a monoamine oxidase (MAO) inhibitor, which can lead to dangerous interactions with certain foods high in tyramine. This interaction can potentially cause a severe hypertensive crisis, a condition characterized by dangerously high blood pressure.

What foods should be avoided while taking Linezolid? Patients must limit or avoid foods and beverages high in tyramine, including:

• Aged cheeses
• Dried or aged meats and sausages
• Preserved fish (e.g., pickled herring)
• Products with high yeast content
• Fermented foods (sauerkraut, kimchi)
• Most soybean products
• Broad/fava beans
• Certain alcoholic beverages (red wine, tap beers)

Adhering to these dietary restrictions is crucial for patient safety. Healthcare providers should offer detailed guidance on food choices and may recommend consulting with a dietitian to ensure a balanced diet while avoiding potentially dangerous interactions.

Common Side Effects of Linezolid 600mg

While Linezolid is generally well-tolerated, like all medications, it can cause side effects in some patients. Understanding these potential effects can help patients recognize and report any issues to their healthcare provider promptly.

What are the most common side effects of Linezolid? Patients may experience:

• Diarrhea
• Headache
• Nausea
• Vomiting
• Dizziness

These side effects are typically mild and may resolve on their own as the body adjusts to the medication. However, if these symptoms persist or worsen, it’s important to consult with a healthcare provider. They can offer strategies to manage these side effects or may consider adjusting the treatment plan if necessary.

Managing Common Side Effects

To alleviate common side effects, patients can try the following strategies:

• Stay well-hydrated to combat diarrhea and nausea
• Take the medication with food if gastrointestinal symptoms are problematic
• Use over-the-counter remedies for headache, as approved by a healthcare provider
• Rest and avoid activities requiring alertness if experiencing dizziness

Serious Side Effects and Warnings

While less common, Linezolid can potentially cause more serious side effects that require immediate medical attention. Recognizing these symptoms early is crucial for patient safety and effective management of the treatment.

What serious side effects should patients watch for? Some of the more severe reactions include:

• Vision changes or loss
• Numbness or tingling in extremities
• Unusual tiredness or weakness
• Easy bruising or bleeding
• Severe headache
• Fast or irregular heartbeat
• Seizures
• Mental/mood changes (e.g., agitation, confusion)

These symptoms may indicate serious conditions such as optic neuropathy, peripheral neuropathy, or serotonin syndrome. Immediate medical evaluation is necessary if any of these symptoms occur.

Serotonin Syndrome: A Rare but Serious Concern

Linezolid’s action as an MAO inhibitor can potentially lead to serotonin syndrome, especially when combined with other medications that increase serotonin levels. This condition can be life-threatening if not recognized and treated promptly.

What are the symptoms of serotonin syndrome? Patients should be alert for:

• Rapid heart rate
• Hallucinations
• Loss of coordination
• Severe dizziness
• Unexplained fever
• Severe nausea, vomiting, or diarrhea
• Muscle twitching or rigidity
• Extreme agitation or restlessness

Drug Interactions and Precautions

Linezolid’s unique mechanism of action as both an antibiotic and an MAO inhibitor necessitates careful consideration of potential drug interactions. These interactions can significantly impact the safety and efficacy of treatment.

What medications should be avoided while taking Linezolid? Patients should inform their healthcare provider about all medications they are taking, especially:

• Selective serotonin reuptake inhibitors (SSRIs)
• Tricyclic antidepressants
• Other MAO inhibitors
• Migraine medications (triptans)
• Certain pain medications (e.g., tramadol, meperidine)
• Cough and cold products containing dextromethorphan
• Herbal supplements (particularly St. John’s Wort)

Healthcare providers must carefully review a patient’s medication list and medical history before prescribing Linezolid to minimize the risk of adverse interactions. In some cases, a washout period may be necessary when transitioning from certain medications to Linezolid treatment.

Special Populations and Considerations

Certain patient groups require extra caution when considering Linezolid treatment:

• Pregnant women: Linezolid should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus
• Nursing mothers: It’s not known if Linezolid passes into breast milk, so caution is advised
• Elderly patients: May be more sensitive to side effects and may require dose adjustment
• Patients with a history of seizures: Linezolid may increase seizure risk
• Individuals with phenylketonuria: Some formulations of Linezolid contain phenylalanine

Monitoring and Follow-up During Linezolid Treatment

Regular monitoring is essential during Linezolid treatment to ensure its effectiveness and minimize the risk of adverse effects. Healthcare providers typically implement a comprehensive monitoring plan tailored to each patient’s specific needs and risk factors.

What aspects of health are monitored during Linezolid treatment? Key areas of focus include:

• Complete blood counts (CBCs) to check for potential bone marrow suppression
• Liver function tests to assess for any hepatotoxicity
• Visual acuity and color vision testing to detect early signs of optic neuropathy
• Blood pressure monitoring, especially in patients with a history of hypertension
• Neurological examinations to check for signs of peripheral neuropathy

The frequency of these monitoring tests may vary depending on the duration of treatment and individual patient factors. Patients should be educated about the importance of keeping all scheduled follow-up appointments and reporting any new or worsening symptoms promptly.

Long-term Considerations

For patients requiring extended Linezolid treatment, additional considerations come into play:

• Increased risk of opportunistic infections, such as oral thrush or vaginal yeast infections
• Potential for vitamin B6 deficiency, which may require supplementation
• Heightened risk of peripheral and optic neuropathy with prolonged use
• Possible development of antibiotic resistance with extended or repeated courses

Healthcare providers must weigh the benefits of continued treatment against these potential risks and may consider alternative therapies or treatment breaks if appropriate.

Patient Education and Empowerment

Effective patient education is crucial for the safe and successful use of Linezolid. Empowering patients with knowledge about their medication can improve adherence, enhance safety, and lead to better treatment outcomes.

How can healthcare providers effectively educate patients about Linezolid? Key strategies include:

• Providing clear, written instructions on dosing, dietary restrictions, and potential side effects
• Educating patients on the importance of completing the full course of antibiotics
• Discussing strategies for managing common side effects
• Emphasizing the need to report any new or worsening symptoms promptly
• Offering guidance on lifestyle modifications necessary during treatment
• Providing resources for further information and support

Patients should be encouraged to ask questions and voice any concerns they may have about their treatment. Open communication between patients and healthcare providers is essential for optimal care and safety.

Tools for Patient Engagement

To enhance patient understanding and adherence, healthcare providers can utilize various tools and resources:

• Medication calendars or reminder apps to help patients stay on schedule
• Dietary guides with lists of foods to avoid and safe alternatives
• Symptom tracking diaries to help patients monitor their progress and any side effects
• Educational videos or interactive modules explaining the medication’s mechanism and importance
• Support group information for patients dealing with complex infections or long-term antibiotic use

By providing comprehensive education and support, healthcare providers can help ensure that patients receive the maximum benefit from Linezolid treatment while minimizing risks and complications.

Linezolid Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Linezolid is an antibiotic used to treat certain serious bacterial infections. It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.Linezolid also belongs to a class of drugs known as MAO inhibitors. It can increase the levels of certain natural substances in the body (such as dopamine, norepinephrine, serotonin) which can increase the chance of certain side effects and food and drug interactions. See How to Use, Side Effects, and Drug Interactions sections for more details.

How to use linezolid oral

Take this medication by mouth with or without food as directed by your doctor, usually every 12 hours. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on age and weight, and they may be directed to take this medication every 8 hours.

To prevent a very serious high blood pressure reaction, it is very important that you follow a special diet recommended by your doctor or dietician to limit your intake of tyramine while you are taking this medicine. Avoid foods and beverages that are high in tyramine, including aged cheeses, dried/aged meats and sausages (such as salami, liverwurst), preserved fish (such as pickled herring), products that contain large amounts of yeast (such as bouillon cubes, powdered soup/gravy, homemade or sourdough bread), fermented foods (such as sauerkraut, kim chee), most soybean products (such as soy sauce, tofu), broad/fava beans, red wine, sherry, tap beers, and vermouth. Consult your doctor or dietician for more details and a complete list of other foods that contain tyramine which you should limit or avoid.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Diarrhea, headache, nausea, vomiting, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: deep/fast breathing, unusual drowsiness, nausea/vomiting that doesn’t stop, numbness/tingling of the hands/feet, unusual tiredness, easy bruising/bleeding.

Get medical help right away if you have any very serious side effects, including: muscle stiffness, increased sweating, vision changes (such as blurred vision, change in color vision, loss of vision), mental/mood changes (such as agitation, confusion), seizure.

This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn’t stop, abdominal or stomach pain/cramping, blood/mucus in your stool.

If you have these symptoms, do not use anti-diarrhea or opioid products because they may make symptoms worse

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take. Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, unexplained fever, severe nausea/vomiting/diarrhea, twitching muscles, unusual agitation/restlessness.

This drug may rarely cause an attack of extremely high blood pressure (hypertensive crisis), which may be fatal. Many drug and food interactions can increase this risk (see How to Use and Drug Interactions sections). Get medical help right away if any of these serious side effects occur: severe headache, fast/slow/irregular/pounding heartbeat, chest pain, neck stiffness/soreness, severe nausea/vomiting, sweating/clammy skin (sometimes with fever), widened pupils, vision changes (such as double/blurred vision), sudden sensitivity to light (photophobia).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking linezolid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, blood/bone marrow problems (such as low red/white blood cells and platelets), kidney problems, liver problems, certain tumor conditions (such as pheochromocytoma, carcinoid syndrome), overactive thyroid, seizures.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

If you have diabetes, linezolid may lower your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Linezolid may cause live bacterial vaccines (such as typhoid vaccine) to not work well. Tell your health care professional that you are using linezolid before having any immunizations/vaccinations.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: diet pills/appetite suppressants (such as diethylpropion), drugs for attention deficit disorder (such as atomoxetine, methylphenidate), apraclonidine, bupropion, buspirone, carbamazepine, cyclobenzaprine, deutetrabenazine, a certain combination product (dextromethorphan/quinidine), levodopa, maprotiline, methyldopa, metoclopramide, certain opioid pain relievers (such as fentanyl, meperidine, methadone, tapentadol), certain drugs for Parkinson’s disease (such as entacapone, tolcapone), certain supplements (such as tryptophan, tyramine), tetrabenazine, tricyclic antidepressants (such as amitriptyline, doxepin), valbenazine.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/”ecstasy,” St. John’s wort, certain antidepressants (including mirtazapine, SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tramadol, certain “triptans” used to treat migraine headaches (such as rizatriptan, sumatriptan, zolmitriptan), among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Some products can interact with linezolid if you take them together, or even if you take them weeks before or after taking linezolid. Tell your doctor or pharmacist if you take anything in the list of products that may interact with this drug, or any of the products that increase serotonin, within 2 weeks before or after taking linezolid. Also tell them if you have taken fluoxetine within 5 weeks before starting linezolid. Ask your doctor how much time to wait between starting or stopping any of these drugs and starting linezolid.

Taking other MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Do not take any other MAO inhibitors (isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using linezolid, report the use of drugs that may increase the risk of extremely high blood pressure (hypertensive crisis) when combined with linezolid, including herbal products (such as ephedra/ma huang), allergy and cold products (including decongestants such as phenylephrine/pseudoephedrine), and stimulants (such as amphetamines, ephedrine, epinephrine). Linezolid should not be used with any of these medications. Talk to your doctor or pharmacist for more details.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

Lab and/or medical tests (such as complete blood count, blood sodium levels) may be done while you are taking this medication. Eye tests should also be done if you take linezolid for 3 months or more, or if you have vision changes. Keep all medical and lab appointments.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

linezolid 600 mg tablet

Color: whiteShape: ovalImprint: I 22

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

linezolid 600 mg tablet

Color: whiteShape: ovalImprint: CIC 1

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

linezolid 600 mg tablet

Color: whiteShape: ovalImprint: L340

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

linezolid 600 mg tablet

Color: whiteShape: oblongImprint: LIN 600

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

linezolid 600 mg tablet

Color: whiteShape: oblongImprint: ZYV 600

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

linezolid 600 mg tablet

Color: whiteShape: oblongImprint: AN 777

This medicine is a white, oval, film-coated, tablet imprinted with “I” and “22”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Apo-Linezolid – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

Linezolid belongs to the family of medications called antibiotics. It is used to kill certain types of bacteria that cause infections in the abdomen, lungs (e.g., pneumonia), urinary tract, skin, and skin-structures (e.g., sweat glands, hair follicles). This medication works by killing bacteria or preventing their growth.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles.  If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each white, oval, biconvex, film-coated tablet with “APO” engraved on one side and “LIN600” on the other, contains 600 mg of linezolid. Nonmedicinal ingredients: methyl cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, and titanium dioxide.

How should I use this medication?

The recommended dose of linezolid depends on the type of infection being treated. For uncomplicated skin and skin-structure infections, the dose is usually 400 mg every 12 hours for 10 to 14 days.  For most other types of infections, the usual dose is 600 mg every 12 hours for 10 to 14 days or for 14 to 28 days (depending on the type of infection being treated). The tablets may be taken with or without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important to take this medication exactly as prescribed by your doctor. Finish all this medication, even if you have started to feel better.

If you miss a dose of this medication, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not use this medication if you:

• are allergic to linezolid or any ingredients of this medication
• have taken monoamine oxidase (MAO) inhibitors (e.g., phenelzine, tranylcypromine) in the past 2 weeks
• have uncontrolled high blood pressure
• have untreated thyroid disease
• have pheochromocytoma (tumour of the adrenal gland)
• are taking medications that increase blood pressure (e.g., pseudoephedrine, epinephrine, dopamine)
• are taking medications that affect the messenger serotonin (e.g., antidepressants, “triptan” migraine medications, buspirone)
• have carcinoid syndrome (a group of symptoms which results from the release of hormones, such as serotonin, from carcinoid tumours)

What side effects are possible with this medication?

Many medications can cause side effects.  A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• change in colour of tongue
• constipation
• diarrhea
• dizziness
• dry mouth
• headache
• increased thirst
• nausea
• rash
• stomach discomfort
• taste changes
• trouble sleeping
• vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• changes in vision (e.g., blurred vision, trouble seeing clearly)
• fever or chills
• increased blood pressure
• ringing in the ears
• symptoms of blood problems (unusual weakness or tiredness, unusual bleeding or bruising, shortness of breath, fever)
• symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
• symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
• symptoms of nerve problems (numbness, tingling, prickling, or burning sensations)
• vaginal yeast infections (itching, white discharge)
• white patches in the mouth or on the tongue or throat

Stop taking the medication and seek immediate medical attention if any of the following occur:

• symptoms of antibiotic-associated diarrhea (severe, watery diarrhea that may be bloody)
• symptoms of a severe allergic reaction (hives, difficulty breathing, swelling of the mouth or throat)
• symptoms of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
• symptoms of lactic acidosis (severe or recurrent nausea, vomiting, or diarrhea)
• symptoms of serotonin syndrome (agitation, confusion, delirium, muscle stiffness, shaking, poor coordination, or seizures)

Some people may experience side effects other than those listed.  Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Antibiotic-associated diarrhea: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated, or pseudomembranous, colitis. Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking linezolid and contact your doctor as soon as possible.

Bacterial resistance: Misuse of an antibiotic such as linezolid may lead to the growth of resistant bacteria that will not be killed by the antibiotic. If this happens, the antibiotic may not work for you in the future. Although you may begin to feel better early in your course of treatment with linezolid, you need to take the full course exactly as directed to finish ridding your body of the infection and to prevent resistant bacteria from taking hold. Do not take linezolid or other antibiotics to treat a viral infection such as the common cold; antibiotics do not kill viruses, and using them to treat viral infections can lead to the growth of resistant bacteria.

Diabetes: Linezolid may cause a loss of blood glucose control and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using this medication. Symptoms of low blood sugar include lightheadedness, weakness, cool, pale skin, or rapid heart rate.

If you have diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Foods with high tyramine content: When using this medication, avoid large quantities of foods or beverages with high tyramine content (e.g., draft beers, red wines, soy sauce, aged cheeses). The combination of linezolid and large amounts of tyramine may result in episodes of dangerously high blood pressure, which can be life-threatening.

Lactic acidosis: Rarely, linezolid may cause a serious condition called lactic acidosis (build-up of lactic acid in the blood). If you experience recurrent nausea or vomiting while taking this medication, get immediate medical attention.

Low blood cell counts: Linezolid may cause low blood cell counts. If you experience unusual weakness or tiredness, unusual bleeding or bruising, shortness of breath, or fever while taking linezolid contact your doctor immediately. Your doctor will monitor your blood cell counts while you are taking this medication.

Nerve problems: Linezolid may cause a nerve problem called peripheral neuropathy, especially when used for longer than recommended. If you experience numbness, tingling or prickling sensations, or burning pain while taking this medication, contact your doctor.

Other medical conditions: Linezolid may cause symptoms of other illnesses to become worse. If you have uncontrolled high blood pressure, pheochromocytoma, carcinoid syndrome, or untreated overactive thyroid, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Overgrowth of organisms: Treatment with antibiotics such as linezolid may allow normal fungus or types of bacteria not killed by the antibiotic to overgrow and cause unwanted infections such as yeast infections. Contact your doctor if you experience fever or chills while taking this medication.

Phenylketonuria: The oral liquid form of linezolid contains aspartame, an ingredient that cannot be broken down in the body by people who have phenylketonuria (a condition where you are lacking the enzyme needed to break down phenylalanine).  People with phenylketonuria should take linezolid tablets instead.

Seizures: This medication may cause seizures, especially for people with a history of seizures or who are at risk for seizures. Get immediate medical attention if you experience a seizure while taking this medication.

Serotonin syndrome: Severe reactions are possible when linezolid is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. These combinations must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

If you are taking antidepressants, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Vision problems: Linezolid may cause vision problems, especially when used for longer than recommended. If you experience vision changes (e.g., blurred vision, changes in colour vision, trouble seeing clearly) while taking this medication, contact your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children and adolescents less than 18 years old.

Seniors: People who are elderly may be more at risk of low sodium levels caused by linezolid.

What other drugs could interact with this medication?

There may be an interaction between linezolid and any of the following:

• alcohol
• amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
• antiemetics (e.g., granisetron, ondansetron)
• antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
• apraclonidine
• atomoxetine
• atropine eye drops
• BCG
• betahistine
• bezafibrate
• brimonidine
• bromocriptine
• fast acting bronchodilators (e.g., salbutamol, terbutaline)
• long acting bronchodilators (e.g., formoterol, salmeterol)
• buprenorphine
• bupropion
• buspirone
• cabergoline
• caffeine
• carbamazepine
• cholera vaccine
• cladribine
• cyclobenzaprine
• decongestant cold medications (e.g., phenylephrine, pseudoephedrine)
• decongestant eye drops and nose sprays (e. g., naphazoline, oxymetazoline, xylometazoline)
• deferiprone
• dexmethylphenidate
• dextromethorphan
• diabetes medications (e.g.,  acarbose, canagliflozin, glyburide, insulin, linagliptin, lixisenatide, metformin, rosiglitazone)
• diphenoxylate
• dipivefrin
• disopyramide
• domperidone
• entacapone
• epinephrine
• ergot alkaloids (e.g., ergotamine, dihydroergotamine)
• esketamine
• hydroxychloroquine
• lanreotide
• levodopa
• lithium
• mesalamine
• methadone
• methyldopa
• methylene blue
• methylphenidate
• metoclopramide
• midodrine
• mifepristone
• mirtazapine
• modafinil
• monoamine oxidase (MAO) inhibitors (e.g., phenelzine, tranylcypromine, moclobemide, selegiline)
• narcotic pain relievers (e.g., fentanyl, hydromorphone, morphine, oxycodone, tapentadol, tramadol)
• octreotide
• olsalazine
• ozanimod
• pasireotide
• pizotifen
• St. John’s wort
• selective serotonin reuptake inhibitors (SSRIs, e.g., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline)
• serotonin agonists (“triptan” migraine medications; e.g., sumatriptan, zolmitriptan, rizatriptan, almotriptan)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, duloxetine, venlafaxine)
• sodium picosulfate
• solriamfetol
• sulfasalazine
• sulfonamide antibiotics (“sulfas”; e.g., sulfadiazine, sulfamethoxazole)
• tetrabenazine
• theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
• trazodone
• tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, imipramine)
• tryptophan
• typhoid vaccine (oral)
• warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Apo-Linezolid

Averozolid 600 mg 10 tablets

Brand name:

Averozolid

Averozolid

Composition:

Each tablet contains:

Linezolid 600 mg

Auxiliary components:

corn starch – 66 mg, microcrystalline cellulose – 97 mg, povidone K30 – 14 mg, croscarmellose sodium – 17 mg, magnesium stearate – 8 mg, colloidal silicon dioxide – 4 mg, calcium hydrogen phosphate – 40 mg, sodium lauryl sulfate – 4 mg.

Features:

Antimicrobial agent, belongs to the class of oxazolidinones. The mechanism of action is due to selective inhibition of protein synthesis in bacteria. By binding to bacterial ribosomes, linezolid prevents the formation of a functional 70S initiation complex, which is a component of the translation process during protein synthesis.

Readings:

Treatment of infectious and inflammatory diseases caused by susceptible to anaerobic and aerobic gram-positive microorganisms (including infections accompanied by bacteremia): community-acquired pneumonia; hospital pneumonia; skin and soft tissue infections; infections caused by Enterococcus spp. (including strains of Enterococcus faecalis and Enterococcus faecium resistant to vancomycin). Infections caused by gram-negative microorganisms, confirmed or suspected (as part of combination therapy).

Dosage and administration:

The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

On average, adults and children over 12 years of age take 600 mg every 12 hours, the duration of treatment is from 10 to 28 days

Children under 11 take 10mg/kg every 8 hours for 10 to 28 days.

Contraindications:

Hypersensitivity to linezolid.

Precautions:

With the development of diarrhea during the use of linezolid, the risk of developing pseudomembranous colitis of varying severity should be taken into account.

In the course of treatment, it is necessary to conduct a clinical blood test in patients with an increased risk of bleeding, a history of myelosuppression, as well as with simultaneous use of drugs that reduce hemoglobin levels, platelet count or their functional properties, as well as in patients receiving linezolid for more than 2 weeks.

Side effects:

From the digestive system: often – taste perversion, nausea, vomiting, diarrhea, abdominal pain (including spastic), flatulence, changes in total bilirubin, ALT, AST, alkaline phosphatase.

On the part of the hematopoietic system: often – reversible anemia, thrombocytopenia, leukopenia, pancytopenia.

Other: often – headache, candidiasis; rarely – cases of peripheral neuropathy and optic neuropathy when used for more than 28 days (the relationship between the use of linezolid and the development of neuropathy has not been proven).

Adverse reactions do not depend on the dose and, as a rule, do not require discontinuation of treatment.

Storage method:

In a dry cool place at a temperature not exceeding 30 degrees.

Packaging:

The cardboard box contains 1 blister of 10 tablets, paper instructions.

composition, indications, dosage, side effects

This drug belongs to the group of antibacterial drugs intended for systemic use.

The active ingredient in this drug is linezolid, a synthetic antibacterial agent that belongs to a new class of antimicrobial drugs, the oxazolidinins.

In vitro activity against Gram-positive aerobic, anaerobic and some Gram-negative bacteria and microorganisms.

Linezolid has the unique ability to selectively inhibit protein synthesis within bacterial cells.

Some types of enterococci, streptococci, staphylococci, as well as clostridia and other anaerobes with gram-positive activity are sensitive to linezolid. It is effective in the fight against some resistant microorganisms – hemophilic infection, others.

Composition and formulation

The main active ingredient of the drug is linezolid.

The following are used as auxiliary components: microcrystalline cellulose, corn starch, sodium starch glycolate, povidone, hydroxypropyl cellulose, magnesium stearate, hypromellose, dibatyl phthalate, talc, titanium dioxide, polyethylene glycol.

Produced in tablet form. One tablet contains 600 mg of linezolid.

Indications

This medicinal product is used in the treatment of infections caused by susceptible anaerobic and aerobic Gram-positive microorganisms, including those accompanied by bacteremia. In particular, such as:

– nosocomial pneumonia;

– community-acquired pneumonia;

– complicated infections of the skin and its structures, in particular infections against the background of diabetic foot without concomitant osteomyelitis, caused by Staphylococcus aureus (methicillin-sensitive and methicillin isolates), Streptococcus pyogenes or Streptococcus agalactiae;

– uncomplicated infections of the skin and its structures caused by Staphylococcus aureus (only methicillin-susceptible isolates) or Streptococcus pyogenes;

– Enterococcal infections, including vancomycin-resistant strains of Enterococcus faecium and faecalis.

If infectious agents include gram-negative organisms, combination therapy is recommended.

Contraindications

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.

Also contraindicated in:

– uncontrolled arterial hypertension;

– pheochromocytoma;

– carcinoid;

– thyrotoxicosis;

– bipolar depression;

– schizoaffective disorder;

– attacks of dizziness.

Concomitant use of any drugs that inhibit monoamine oxidase A and B (in particular phenelzine, isocarboxazid, selegiline, moclobemide), or within two weeks after taking such drugs.

Concomitant use with drugs – serotonin reuptake inhibitors, tricyclic antidepressants, serotonin 5-HT 1 receptor agonists (triptans), direct and indirect sympathomimetics (including adrenergic bronchodilators, pseudoephedrine, phenylpropanolamine), vasopressors (epinephrine, norepinephrine), dopaminergic compounds (dopamine, dobutamine), pethidine or buspirone.

Not for use in pediatric patients under 12 years of age.

Use in pregnancy and lactation

Not intended for use in pregnant women.

Also do not use during lactation.

Dosage and Administration

This drug is recommended to take 1 tablet of 600 mg 2 times a day, regardless of food intake.

The duration of treatment is determined by the attending physician, depending on the response of the patient’s body to treatment, the course of the disease.

The maximum duration of treatment is 28 days.

Recommended duration of treatment for:

– hospital and community-acquired pneumonia, complicated infections of the skin and its structures – 10-14 days;

– infections caused by Enterococcusfaecium resistant to vancomycin, in particular infections accompanied by bacteremia – from 14 to 28 days.

In the treatment of uncomplicated infections of the skin and its structures, the dosage for adults can be reduced to 400 mg 2 times a day, the duration of treatment is 10-14 days.

Elderly patients and patients with renal and hepatic insufficiency do not need to adjust the dosage and duration of treatment with this drug.

Overdose

No cases of overdose with this drug have been observed so far.

In case of overdose, hemodialysis is recommended to remove the drug from the body.

Side effects

Therapy with this drug may cause adverse reactions in the form of:

– oral, vaginal candidiasis, fungal infections, vaginitis, colitis, including pseudomembranous;

– eosinophilia, leukopenia, neutropenia, thrombocytopenia, myelosuppression, pancytopenia, sideroblastic anemia;

– anaphylactic shock;

– lactic acidosis, hyponatremia;

– insomnia;

– headache, taste perversion, dizziness, hypesthesia, paresthesia, serotonin syndrome, convulsions, peripheral neuropathy;

– visual impairment, optic neuritis, optic neuropathy, changes in color perception, visual sensations, visual field defect;

– ringing in the ears;

– arrhythmias, tachycardias;

– arterial hypertension, phlebitis, thrombophlebitis, transient ischemic attack;

– diarrhea, nausea, vomiting, abdominal pain, constipation, dry mouth, dyspepsia, gastritis, abdominal distension, glossitis, loose stools, pancreatitis, stomatitis, discoloration of the tongue;

– polyuria, renal failure;

– other adverse reactions.