How does alpha-lipoic acid impact weight loss. What are the key benefits of alpha-lipoic acid supplements. Are there any side effects associated with alpha-lipoic acid. How does alpha-lipoic acid affect blood sugar levels. What is the recommended dosage for alpha-lipoic acid supplements.

What Is Alpha-Lipoic Acid and How Does It Work?

Alpha-lipoic acid is an organic compound found naturally in all human cells. It plays a crucial role in cellular energy production within the mitochondria, often referred to as the powerhouse of cells. This powerful antioxidant has gained significant attention in recent years due to its unique properties and potential health benefits.

What sets alpha-lipoic acid apart from other antioxidants? Unlike most antioxidants that are either water- or fat-soluble, alpha-lipoic acid is both. This dual solubility allows it to function in every cell and tissue in the body, making it exceptionally versatile.

Natural Sources of Alpha-Lipoic Acid

While the human body produces alpha-lipoic acid in small amounts, many people turn to dietary sources or supplements to increase their intake. Some excellent food sources include:

• Red meat
• Organ meats
• Broccoli
• Tomatoes
• Spinach
• Brussels sprouts

It’s worth noting that supplements can provide significantly higher doses of alpha-lipoic acid compared to food sources – up to 1,000 times more in some cases.

The Impact of Alpha-Lipoic Acid on Weight Loss

Does alpha-lipoic acid really help with weight loss? The answer is not straightforward. While animal studies have shown promising results, human studies indicate that the effect on weight loss is relatively modest.

How does alpha-lipoic acid potentially contribute to weight loss? Research suggests it may work by:

1. Reducing the activity of AMP-activated protein kinase (AMPK) in the brain’s hypothalamus, which may decrease feelings of hunger
2. Increasing the number of calories burned at rest

However, the real-world impact appears to be limited. An analysis of 12 studies found that people taking alpha-lipoic acid supplements lost an average of only 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks. Another analysis showed a slightly higher average weight loss of 2.8 pounds (1.27 kg) over 23 weeks.

Alpha-Lipoic Acid and Blood Sugar Regulation

One of the most promising areas of research for alpha-lipoic acid is its potential to help regulate blood sugar levels, particularly in people with diabetes or metabolic syndrome.

How does alpha-lipoic acid affect blood glucose? Studies have shown that it may:

• Lower blood sugar levels (by up to 64% in animal studies)
• Reduce insulin resistance
• Lower fasting blood glucose levels
• Decrease HbA1c levels (a marker of long-term blood sugar control)

Scientists believe that alpha-lipoic acid helps improve insulin sensitivity by promoting the removal of fat that has accumulated in muscle cells. This fat accumulation can make insulin less effective, contributing to insulin resistance and elevated blood sugar levels.

Additional Health Benefits of Alpha-Lipoic Acid

Beyond its potential effects on weight and blood sugar, alpha-lipoic acid has been associated with several other health benefits. These include:

Reduced Inflammation

Chronic inflammation is linked to various health problems, including heart disease, cancer, and diabetes. Alpha-lipoic acid’s antioxidant properties may help combat oxidative stress and reduce inflammation throughout the body.

Improved Nerve Function

Some studies suggest that alpha-lipoic acid may help improve nerve function in people with diabetic neuropathy, a common complication of diabetes that causes nerve damage.

Slowed Skin Aging

The antioxidant properties of alpha-lipoic acid may help protect skin cells from damage caused by free radicals, potentially slowing the visible signs of aging.

Cognitive Health

Emerging research indicates that alpha-lipoic acid might have neuroprotective properties, potentially benefiting cognitive function and reducing the risk of neurodegenerative diseases.

Potential Side Effects and Safety Considerations

Is alpha-lipoic acid safe for everyone? While generally considered safe when taken as directed, there are some potential side effects and interactions to be aware of:

• Gastrointestinal distress: Some people may experience nausea, stomach upset, or diarrhea.
• Skin rash: In rare cases, alpha-lipoic acid may cause skin reactions.
• Low blood sugar: Due to its blood sugar-lowering effects, people with diabetes should monitor their blood glucose levels closely when taking alpha-lipoic acid.
• Thyroid function: Alpha-lipoic acid may affect thyroid hormone levels, so individuals with thyroid conditions should consult their healthcare provider before use.

It’s always advisable to consult with a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

Recommended Dosage and Administration

What is the optimal dosage of alpha-lipoic acid? The appropriate dose can vary depending on the individual and the intended use. However, most studies have used doses ranging from 300-600 mg per day for adults.

How should alpha-lipoic acid be taken? It’s typically recommended to take alpha-lipoic acid on an empty stomach, as food can decrease its absorption. However, if gastrointestinal side effects occur, it may be taken with food.

Forms of Alpha-Lipoic Acid Supplements

Alpha-lipoic acid supplements are available in various forms, including:

• Capsules
• Tablets
• Softgels
• Liquid formulations

Some supplements combine alpha-lipoic acid with other antioxidants or nutrients for potential synergistic effects.

Choosing and Using Alpha-Lipoic Acid Supplements

When selecting an alpha-lipoic acid supplement, consider the following factors:

1. Quality and purity: Look for products from reputable manufacturers that undergo third-party testing.
2. Form: Choose a form that’s convenient for you and suits your needs (e.g., capsules vs. liquid).
3. Dosage: Ensure the product provides an appropriate dose based on your health goals and healthcare provider’s recommendations.
4. Additional ingredients: Some formulations may include complementary nutrients or compounds.

Remember that while supplements can be beneficial, they’re not a substitute for a balanced diet and healthy lifestyle. Alpha-lipoic acid should be used as part of a comprehensive approach to health and wellness.

Future Research and Potential Applications

As interest in alpha-lipoic acid continues to grow, researchers are exploring its potential in various areas of health and medicine. Some promising avenues of investigation include:

Neurodegenerative Diseases

Can alpha-lipoic acid help prevent or slow the progression of conditions like Alzheimer’s and Parkinson’s disease? Early studies suggest it may have neuroprotective properties, but more research is needed to confirm these effects in humans.

Cardiovascular Health

Researchers are investigating whether alpha-lipoic acid’s antioxidant and anti-inflammatory properties could benefit heart health and reduce the risk of cardiovascular diseases.

Cancer Prevention and Treatment

Some preliminary studies have explored the potential of alpha-lipoic acid in cancer prevention and as an adjunct to conventional cancer treatments. However, this area requires extensive further research before any conclusions can be drawn.

Liver Health

Alpha-lipoic acid’s antioxidant properties have led to investigations into its potential to protect the liver from damage and support liver function in various conditions.

As research continues, our understanding of alpha-lipoic acid’s mechanisms and potential applications is likely to expand, potentially opening up new avenues for its use in health and medicine.

In conclusion, alpha-lipoic acid is a versatile antioxidant with a range of potential health benefits. While its effects on weight loss appear to be modest, its impact on blood sugar regulation and other aspects of health make it an intriguing compound for further study. As with any supplement, it’s essential to approach its use thoughtfully and in consultation with healthcare professionals. By understanding its properties, benefits, and potential risks, individuals can make informed decisions about incorporating alpha-lipoic acid into their health and wellness routines.

Weight Loss, Other Benefits, and Side Effects

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

• Evaluate ingredients and composition: Do they have the potential to cause harm?
• Fact-check all health claims: Do they align with the current body of scientific evidence?
• Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Alpha-lipoic acid may provide health benefits, including supporting weight loss and lowering blood sugar levels. You can get it through food and supplements with minimal side effects.

Alpha-lipoic acid has gained a lot of attention in recent years.

It’s an organic compound that acts as a powerful antioxidant in the body.

Your body produces alpha-lipoic acid naturally, but it’s also found in a variety of foods and as a dietary supplement.

Research suggests that it may play a role in weight loss, diabetes, and other health conditions.

However, many people wonder whether it’s effective.

This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.

Alpha-lipoic acid is an organic compound found in all human cells.

It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).

What’s more, it has powerful antioxidant properties.

Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).

For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.

The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.

Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.

Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.

That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).

Summary

Alpha-lipoic acid is an organic compound that works as an antioxidant. It’s made in the mitochondria of cells but also found in foods and supplements.

Research has shown that alpha-lipoic acid may affect weight loss in several ways.

Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).

When AMPK is more active, it may increase feelings of hunger.

On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).

However, human studies show that alpha-lipoic acid only slightly impacts weight loss.

An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).

In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).

In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.

Summary

Though alpha-lipoic acid has properties that may promote weight loss, its overall effect in humans seems negligible.

Diabetes affects more than 400 million adults worldwide (10).

A key feature of uncontrolled diabetes is high blood sugar levels. If left untreated, this can cause health problems, such as vision loss, heart disease, and kidney failure.

Alpha-lipoic acid has become popular as a potential aid for diabetes, as it’s been shown to lower blood sugar levels in both animals and humans.

In animal studies, it has lowered blood sugar levels by up to 64% (11, 12).

Other studies in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels.

Scientists believe that alpha-lipoic acid helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise makes insulin less effective (13).

Moreover, alpha-lipoic acid may lower the risk of diabetes complications.

It’s proven to ease symptoms of nerve damage and lower the risk of diabetic retinopathy (eye damage) that can occur with uncontrolled diabetes (14, 15, 16).

It’s believed that this effect is due to the powerful antioxidant properties of alpha-lipoic acid (17).

Though alpha-lipoic acid has been shown to aid blood sugar control, it’s not considered a complete treatment for diabetes. If you have diabetes and want to try alpha-lipoic acid, it’s best to first talk with your doctor, as it may interact with your medications.

Summary

Alpha-lipoic acid has been shown to reduce insulin resistance, improve blood sugar control, ease symptoms of nerve damage, and lower the risk of diabetic retinopathy.

Alpha-lipoic acid has been linked to a variety of other health benefits.

May Reduce Skin Aging

Research has shown that alpha-lipoic acid may help fight signs of skin aging.

In one human study, scientists found that applying a cream containing alpha-lipoic acid to the skin reduced fine lines, wrinkles, and skin roughness with no side effects (18).

When alpha-lipoic acid is applied to the skin, it incorporates itself into the skin’s inner layers and offers antioxidant protection against the sun’s harmful UV radiation (19, 20).

Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as glutathione, which help protect against skin damage and may reduce signs of aging (21, 22).

May slow memory loss

Memory loss is a common concern among older adults.

It’s believed that damage from oxidative stress plays a critical role in memory loss (23).

Because alpha-lipoic acid is a powerful antioxidant, studies have examined its ability to slow the progression of disorders characterized by memory loss, such as Alzheimer’s disease.

Both human and lab studies suggest that alpha-lipoic acid slows the progression of Alzheimer’s disease by neutralizing free radicals and suppressing inflammation (24, 25, 26).

However, only a handful of studies have investigated alpha-lipoic acid and memory loss-related disorders. More research is needed before alpha-lipoic acid can be recommended for treatment.

Promotes healthy nerve function

Research has shown that alpha-lipoic acid promotes healthy nerve function.

In fact, it’s been found to slow the progression of carpal tunnel syndrome in its early stages. This condition is characterized by numbness or tingling in the hand caused by a pinched nerve (27).

Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes (28).

Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes (14, 15).

Reduces inflammation

Chronic inflammation is linked to several diseases, including cancer and diabetes.

Alpha-lipoic acid has been shown to lower several markers of inflammation.

In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein (CRP) in adults with high levels of CRP (29).

In test-tube studies, alpha-lipoic acid has reduced markers of inflammation, including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9, and IL-6 (30, 31, 32, 33).

May lower heart disease risk factors

Heart disease is responsible for one in four deaths in America (34).

Research from a combination of lab, animal, and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors.

First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk (35).

Second, it’s been shown to improve endothelial dysfunction — a condition in which blood vessels cannot dilate properly, which also raises the risks of heart attack and stroke (36, 37).

What’s more, a review of studies found that taking an alpha-lipoic acid supplement lowered triglyceride and LDL (bad) cholesterol levels in adults with metabolic disease (13).

Summary

Alpha-lipoic acid has strong antioxidant properties, which may reduce inflammation and skin aging, promote healthy nerve function, lower heart disease risk factors, and slow the progression of memory loss disorders.

Alpha-lipoic acid is generally considered safe with little to no side effects.

In some cases, people may experience mild symptoms like nausea, rashes, or itching.

However, research shows that adults can take up to 2,400 mg without harmful side effects (38).

Higher doses are not recommended, as there’s no evidence that they provide extra benefits.

Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue (38, 39).

To date, very few studies have looked at the safety of alpha-lipoic acid in children and pregnant women. These populations should not take it unless advised to do so by their healthcare provider.

If you have diabetes, consult your healthcare provider before taking alpha-lipoic acid, as it may interact with other medicines that help lower blood sugar levels.

Summary

Alpha-lipoic acid is generally safe with little to no side effects. In some instances, people may experience mild symptoms, such as nausea, rashes, or itching.

Alpha-lipoic acid is found naturally in several foods.

Good sources of alpha-lipoic acid include (3):

• red meats
• organ meats like liver, heart, kidney, etc.
• broccoli
• spinach
• tomatoes
• Brussels sprouts
• potatoes
• green peas
• rice bran

Alpha-lipoic acid is also available as a supplement and can be found in many health stores and online. Supplements can contain up to 1,000 times more alpha-lipoic acid than foods (3).

Alpha-lipoic supplements are best taken on an empty stomach, as certain foods can lower the acid’s bioavailability (40).

Though there is no set dosage, most evidence suggests that 300–600 mg is sufficient and safe. Alternatively, you can follow the instructions on the back of the bottle.

People with diabetic complications or cognitive disorders may require more alpha-lipoic acid. In such cases, it’s best to ask your healthcare practitioner how much is most effective.

Summary

Alpha-lipoic acid is naturally present in red meats, organ meats, and several plants. It’s also available as a dietary supplement sold in health stores or online.

Alpha-lipoic acid is an organic compound with antioxidant properties. It’s made in small amounts by your body but also found in foods and as a supplement.

It may benefit diabetes, skin aging, memory, heart health, and weight loss.

Dosages of 300–600 mg seem effective and safe without serious side effects.

Weight Loss, Other Benefits, and Side Effects

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

• Evaluate ingredients and composition: Do they have the potential to cause harm?
• Fact-check all health claims: Do they align with the current body of scientific evidence?
• Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Alpha-lipoic acid may provide health benefits, including supporting weight loss and lowering blood sugar levels. You can get it through food and supplements with minimal side effects.

Alpha-lipoic acid has gained a lot of attention in recent years.

It’s an organic compound that acts as a powerful antioxidant in the body.

Your body produces alpha-lipoic acid naturally, but it’s also found in a variety of foods and as a dietary supplement.

Research suggests that it may play a role in weight loss, diabetes, and other health conditions.

However, many people wonder whether it’s effective.

This article reviews alpha-lipoic acid, its benefits, side effects, and recommended dosage.

Alpha-lipoic acid is an organic compound found in all human cells.

It’s made inside the mitochondrion — also known as the powerhouse of cells — where it helps enzymes turn nutrients into energy (1).

What’s more, it has powerful antioxidant properties.

Alpha-lipoic acid is both water- and fat-soluble, which allows it to work in every cell or tissue in the body. Meanwhile, most other antioxidants are either water- or fat-soluble (2).

For instance, vitamin C is only water-soluble, while vitamin E is only fat-soluble.

The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function.

Humans only produce alpha-lipoic acid in small amounts. That’s why many turn to certain foods or supplements to optimize their intake.

Animal products like red meat and organ meats are great sources of alpha-lipoic acid, but plant foods like broccoli, tomatoes, spinach, and Brussels sprouts also contain it.

That said, supplements can pack up to 1,000 times more alpha-lipoic acid than food sources (3).

Summary

Alpha-lipoic acid is an organic compound that works as an antioxidant. It’s made in the mitochondria of cells but also found in foods and supplements.

Research has shown that alpha-lipoic acid may affect weight loss in several ways.

Animal studies indicate that it can reduce the activity of the enzyme AMP-activated protein kinase (AMPK), which is located in your brain’s hypothalamus (4, 5).

When AMPK is more active, it may increase feelings of hunger.

On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest. Thus, animals who took alpha-lipoic acid burned more calories (6, 7).

However, human studies show that alpha-lipoic acid only slightly impacts weight loss.

An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.52 pounds (0.69 kg) more than those taking a placebo over an average of 14 weeks (8).

In the same analysis, alpha-lipoic acid did not significantly affect waist circumference.

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks (9).

In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans.

Summary

Though alpha-lipoic acid has properties that may promote weight loss, its overall effect in humans seems negligible.

Diabetes affects more than 400 million adults worldwide (10).

A key feature of uncontrolled diabetes is high blood sugar levels. If left untreated, this can cause health problems, such as vision loss, heart disease, and kidney failure.

Alpha-lipoic acid has become popular as a potential aid for diabetes, as it’s been shown to lower blood sugar levels in both animals and humans.

In animal studies, it has lowered blood sugar levels by up to 64% (11, 12).

Other studies in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels.

Scientists believe that alpha-lipoic acid helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise makes insulin less effective (13).

Moreover, alpha-lipoic acid may lower the risk of diabetes complications.

It’s proven to ease symptoms of nerve damage and lower the risk of diabetic retinopathy (eye damage) that can occur with uncontrolled diabetes (14, 15, 16).

It’s believed that this effect is due to the powerful antioxidant properties of alpha-lipoic acid (17).

Though alpha-lipoic acid has been shown to aid blood sugar control, it’s not considered a complete treatment for diabetes. If you have diabetes and want to try alpha-lipoic acid, it’s best to first talk with your doctor, as it may interact with your medications.

Summary

Alpha-lipoic acid has been shown to reduce insulin resistance, improve blood sugar control, ease symptoms of nerve damage, and lower the risk of diabetic retinopathy.

Alpha-lipoic acid has been linked to a variety of other health benefits.

May Reduce Skin Aging

Research has shown that alpha-lipoic acid may help fight signs of skin aging.

In one human study, scientists found that applying a cream containing alpha-lipoic acid to the skin reduced fine lines, wrinkles, and skin roughness with no side effects (18).

When alpha-lipoic acid is applied to the skin, it incorporates itself into the skin’s inner layers and offers antioxidant protection against the sun’s harmful UV radiation (19, 20).

Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as glutathione, which help protect against skin damage and may reduce signs of aging (21, 22).

May slow memory loss

Memory loss is a common concern among older adults.

It’s believed that damage from oxidative stress plays a critical role in memory loss (23).

Because alpha-lipoic acid is a powerful antioxidant, studies have examined its ability to slow the progression of disorders characterized by memory loss, such as Alzheimer’s disease.

Both human and lab studies suggest that alpha-lipoic acid slows the progression of Alzheimer’s disease by neutralizing free radicals and suppressing inflammation (24, 25, 26).

However, only a handful of studies have investigated alpha-lipoic acid and memory loss-related disorders. More research is needed before alpha-lipoic acid can be recommended for treatment.

Promotes healthy nerve function

Research has shown that alpha-lipoic acid promotes healthy nerve function.

In fact, it’s been found to slow the progression of carpal tunnel syndrome in its early stages. This condition is characterized by numbness or tingling in the hand caused by a pinched nerve (27).

Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes (28).

Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes (14, 15).

Reduces inflammation

Chronic inflammation is linked to several diseases, including cancer and diabetes.

Alpha-lipoic acid has been shown to lower several markers of inflammation.

In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein (CRP) in adults with high levels of CRP (29).

In test-tube studies, alpha-lipoic acid has reduced markers of inflammation, including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9, and IL-6 (30, 31, 32, 33).

May lower heart disease risk factors

Heart disease is responsible for one in four deaths in America (34).

Research from a combination of lab, animal, and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors.

First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk (35).

Second, it’s been shown to improve endothelial dysfunction — a condition in which blood vessels cannot dilate properly, which also raises the risks of heart attack and stroke (36, 37).

What’s more, a review of studies found that taking an alpha-lipoic acid supplement lowered triglyceride and LDL (bad) cholesterol levels in adults with metabolic disease (13).

Summary

Alpha-lipoic acid has strong antioxidant properties, which may reduce inflammation and skin aging, promote healthy nerve function, lower heart disease risk factors, and slow the progression of memory loss disorders.

Alpha-lipoic acid is generally considered safe with little to no side effects.

In some cases, people may experience mild symptoms like nausea, rashes, or itching.

However, research shows that adults can take up to 2,400 mg without harmful side effects (38).

Higher doses are not recommended, as there’s no evidence that they provide extra benefits.

Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue (38, 39).

To date, very few studies have looked at the safety of alpha-lipoic acid in children and pregnant women. These populations should not take it unless advised to do so by their healthcare provider.

If you have diabetes, consult your healthcare provider before taking alpha-lipoic acid, as it may interact with other medicines that help lower blood sugar levels.

Summary

Alpha-lipoic acid is generally safe with little to no side effects. In some instances, people may experience mild symptoms, such as nausea, rashes, or itching.

Alpha-lipoic acid is found naturally in several foods.

Good sources of alpha-lipoic acid include (3):

• red meats
• organ meats like liver, heart, kidney, etc.
• broccoli
• spinach
• tomatoes
• Brussels sprouts
• potatoes
• green peas
• rice bran

Alpha-lipoic acid is also available as a supplement and can be found in many health stores and online. Supplements can contain up to 1,000 times more alpha-lipoic acid than foods (3).

Alpha-lipoic supplements are best taken on an empty stomach, as certain foods can lower the acid’s bioavailability (40).

Though there is no set dosage, most evidence suggests that 300–600 mg is sufficient and safe. Alternatively, you can follow the instructions on the back of the bottle.

People with diabetic complications or cognitive disorders may require more alpha-lipoic acid. In such cases, it’s best to ask your healthcare practitioner how much is most effective.

Summary

Alpha-lipoic acid is naturally present in red meats, organ meats, and several plants. It’s also available as a dietary supplement sold in health stores or online.

Alpha-lipoic acid is an organic compound with antioxidant properties. It’s made in small amounts by your body but also found in foods and as a supplement.

It may benefit diabetes, skin aging, memory, heart health, and weight loss.

Dosages of 300–600 mg seem effective and safe without serious side effects.

Lipoic acid instructions for use, price: Dosage, side effects, contraindications

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED. Fatty liver disease Cholesterol

Author of the article

Ibrayeva Ekaterina Anatolyevna,

Diploma of pharmaceutical education: 105924 3510869 reg. number 31955

All authors

Contents of the article

• Alpha-lipoic acid: properties
• Lipoic acid: what it is for
• Lipoic acid: for weight loss dosage
• Lipoic acid: harm and benefit
• Alpha lipoic acid contraindications
• Lipoic acid: side effects
• Lipoic acid and alcohol: compatibility
• Summary 90 014
• Ask an expert about the topic of the article

Improper diet, sedentary lifestyle, smoking and excess weight lead to the development of a serious disease – type 2 diabetes. In 2014, the incidence among adults aged 18 and over was 8.5%. However, according to 2019 statisticsthe figure has grown. Diabetes was the direct cause of 1.5 million deaths, and 48% of them occurred before the age of 70 years. Diabetes mellitus is terrible not only for its symptoms, but also for its complications. Over time, it leads to damage to many systems and organs, especially nerves and blood vessels.

The pharmacist will tell you about Lipoic Acid: will acquaint you with its properties, indications for use and administration for weight loss, as well as side effects and contraindications.

Alpha-lipoic acid: properties

Lipoic or alpha-lipoic acid is a drug from the group of metabolic agents. In simple terms, this is a medicine for normalizing the metabolism between tissue cells and organs. In this case, lipoic acid:

• Helps lower blood glucose levels;
• Improves the absorption of glucose by liver cells, converting it into glycogen – a reserve energy reserve;
• Helps overcome insulin resistance – cell resistance to insulin;
• Regulates carbohydrate and fat metabolism;
• Reduces “bad” cholesterol levels;
• Normalizes liver function;
• Improves trophism and conductivity of the nervous tissue.

It is a common misconception that lipoic acid is a vitamin, but this is not entirely true. The drug is really similar to the B vitamins in its properties and biological action, however, it refers to fatty acids and vitamin-like substances.

All goods Lipoic acid

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Lipoic acid: what it is for

Lipoic acid preparations are available in the form of tablets and capsules. In addition, you can find a powder for the preparation of a solution for intravenous administration under other trade names. The use of the drug depends on the dosage, which varies from 15 to 600 mg.

High doses of lipoic acid (300 and 600 mg) are prescribed for two types of polyneuropathy – damage to nerve fibers of a non-inflammatory nature:

• Diabetic or otherwise developing on the background of high blood sugar and impaired metabolism. Due to these reasons, toxic metabolic products accumulate in tissues and oxygen supply to neurons decreases;
• Alcoholic or otherwise caused by excessive consumption of alcoholic beverages, the products of which lead to harmful effects on organs and tissues, including nerve cells.

Lipoic acid improves the functional state of nerve fibers and reduces the manifestations of the disease: impaired skin sensitivity, burning, pain and numbness of the extremities.

Lipoic acid for the liver is used in doses up to 50 mg. The drug is prescribed for fatty liver, cirrhosis, hepatitis A, high cholesterol and poisoning.

Lipoic acid: for weight loss dosage

A common question asked by people seeking advice is whether lipoic acid is used for weight loss. Indeed, lipoic acid in minimal dosages is a frequent component of dietary supplements for weight loss. The substance helps in the fight against extra pounds by speeding up the metabolism, but it only works if you follow a diet and exercise.

Doses of lipoic acid are selected individually, depending on the initial body weight and the intensity of physical activity. It is worth remembering that each drug has contraindications and side effects, so you should not take lipoic acid unnecessarily.

Lipoic acid: harms and benefits

Lipoic acid – benefits for patients with diabetes and liver disorders. As mentioned above, nutritional supplements with lipoic acid have also found application in the fight against excess body weight. However, the drug is not suitable for every person and should be taken only after consulting a doctor.

Abuse of lipoic acid tablets and capsules can lead not only to the development of adverse reactions, but also to overdose. Symptoms of exceeding the permissible dose are as follows: headache, nausea and vomiting, convulsive seizures, severe disorders of blood clotting and acid-base balance.

Alpha-lipoic acid contraindications

Alpha-lipoic acid preparations at recommended dosages are safe enough to use. However, lipoic acid still has contraindications. These include:

• Individual intolerance to the components of the drug;
• Pregnancy and lactation;
• Children under 18 years of age.

Lipoic acid: side effects

• Nausea and vomiting;
• Heartburn;
• Abdominal pain;
• Allergic reactions up to the development of anaphylaxis;
• Eczema;
• Change in taste sensations;
• Excessive reduction in sugar levels;
• Dizziness.

Lipoic acid and alcohol: compatibility

During treatment, you should strictly refrain from drinking alcohol, as they reduce the therapeutic effect of the drug, and also increase the manifestations of polyneuropathy. You should not take alcohol in between courses of Lipoic acid.

Summary

• Lipoic or alpha-lipoic acid is a drug from the group of metabolic agents.
• High doses of lipoic acid (300 and 600 mg) are prescribed for two types of polyneuropathy – damage to nerve fibers of a non-inflammatory nature.
• Lipoic acid for the liver is used in doses up to 50 mg.
• Low dose lipoic acid is a common ingredient in dietary supplements for weight loss.
• Abuse of lipoic acid tablets and capsules can lead not only to the development of adverse reactions, but also to overdose.
• Lipoic acid has contraindications and side effects.
• During treatment, you should strictly refrain from drinking alcohol.

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instructions for use, contraindications and side effects, how to take it correctly

ALA is found in a limited number of foods, which is often not enough to achieve a full daily requirement. In this case, alpha lipoic acid is best taken as a supplement.

What is alpha-lipoic acid

Alpha-lipoic acid is a natural substance that belongs to the group of conditional vitamins. It was first opened at 1950s. It has a powerful antioxidant effect, improves the action of insulin. Alpha-Lipoic Acid is also often referred to as vitamin N. The substance is involved in many biological processes. Considered conditionally indispensable. That is, the body is able to produce alpha-lipoic acid to meet the minimum needs and prevent deficiency. Vitamin N must be obtained from food or supplements to meet your full vitamin N requirement.

In the body, alpha-lipoic acid is needed for:

• Regulation of carbohydrate and fat metabolism;

• Improving the functioning of the liver;

• Suppression of free radical activity;

• Improving the functioning of the liver;

• Decreased blood sugar levels;

• Controlling the breakdown of amino acids.

It is important to consider that over the years, the already low synthesis of a substance will decrease. Therefore, to obtain the norm of alpha lipoic acid, it is necessary to increase the number of foods in the diet that contain the substance in large quantities, or take it as a supplement.

ALA content in products

The value of vitamin N is also due to the fact that the substance is found in a limited number of foods. Getting the daily norm is problematic even with a varied diet. Therefore, it is important to know where alpha-lipoic acid is found in order to eat foods as often as possible. The highest concentration of the substance is observed in:

• Green pea;

• tomatoes;

• Kidneys and liver;

• All types of cabbage;

• Brown and black rice;

• Brewer’s yeast.

A large concentration of the substance is found in broccoli, Brussels sprouts and other types of cabbage. If you are consuming these foods on a daily basis, taking alpha lipoic acid from dietary supplements will not be mandatory.

Benefits of ALA

Alpha lipoic acid is very beneficial for the body. It has a lot of positive effects. The main actions of the additive:

• The most powerful antioxidant, takes part in the production of many vital enzymes;

• Promotes the removal of heavy metals and other compounds harmful to the body;

• Improves the work of the digestive organs;

• Protects the cardiovascular and nervous systems;

• Protects DNA;

• Counteracts free radicals, protects cells, reduces oxidative processes;

• Reduces muscle breakdown;

• Slows down the aging process, has a moderate rejuvenating effect on cells;

• Strengthens the processes of preserving glycogen in the muscles;

• Improves recovery after heavy physical exertion in sports;

• Increases the effectiveness of other antioxidants through a synergistic effect.

Separately, the use of alpha-lipoic acid for weight loss should be considered. There is an opinion that ALA has fat burning properties. Despite the acceleration of weight loss, the substance does not have a direct effect on fat burning. Alpha-lipoic acid is needed to increase thermogenesis, which provokes an increase in calorie consumption. This means that ALA can indeed speed up the process of losing excess fat, but only in combination with diet and exercise. Otherwise, the substance, like a fat burner, will be practically useless. Also, ALA does not have any anabolic effect. Therefore, drinking alpha-lipoic acid to increase muscle mass does not make any sense.

Especially alpha-lipoic acid is needed by women. It is used as part of general therapy for menopause, is used to increase fertility and improve the functioning of the reproductive system in women. Vitamin N is also used for cosmetic purposes. There is proven scientific evidence that shows a tangible effect of the substance on skin rejuvenation and wrinkle smoothing. ALA can be helpful in reducing under eye circles and firming up the skin.

Indications for use ALC

Given the fact that the substance is almost not produced by the body, alpha-lipoic acid has a wide list of indications for use. The main indications include:

• As part of complex therapy for the treatment and prevention of atherosclerosis;

• With cirrhosis and other liver diseases;

• With a decrease in kidney function, poisoning;

• In cases of heart failure;

• With diabetes;

• With pancreatitis.

Sports applications

In sports, ALA is used as an antioxidant to reduce the effects of stress, increase endurance, and enhance recovery. Regular exercise significantly increases the formation of free radicals, and also increases oxidative stress in the muscles. The use of alpha lipoic acid will help you recover better and reduce the effects of stress. This will potentially help reduce muscle breakdown, allowing athletes to recover better and train more often. In addition to the antioxidant effect, the insulin-like action of ALA is also valued in the sports field. The substance increases the absorption of glucose in the muscles, which contributes to:

• Better store glycogen;

• Increase the amount of glucose in the muscles;

• Maintain stable blood sugar levels;

• Accelerate insulin-related uptake in muscles;

Contraindications and side effects ALA

The potential benefits and harms of alpha-lipoic acid are considered to be sufficiently studied, which allows us to regard the substance as completely safe. However, there are a small number of contraindications for which ALA should be taken with caution or avoided.

Contraindications for alpha lipoic acid:

• With increased acidity of the stomach;

• With anemia;

• Before the age of 16;

• With frequent allergic reactions;

• During pregnancy and lactation;

• In cases of individual intolerance.

It is also not recommended to combine the intake of ALA with alcoholic beverages. This can lead to seizures and disrupt blood clotting.

Methods of application and dosage

The conditions for taking are always indicated in the instructions for use of alpha lipoic acid. Dosages can vary greatly, depending on the destination. For medicinal purposes, for example, to relieve diabetic complications, ALA can be used in large dosages: over 600 mg and up to 1.8 g per day. Reception is carried out half an hour before meals.

In sports, the daily allowance of alpha lipoic acid varies, depending on goals, intensity of exercise, and other factors. Basically, it ranges from 200 to 500 mg. Exceeding the upper limit of the norm does not make sense, since it does not give a tangible increase in efficiency with an increase in the risk of side effects.

For preventive purposes, it is recommended to limit dosages in the amount of 100-150 mg / day. A portion is washed down with a glass of water before or during a meal. If desired, the daily rate can be divided into several doses, but on training days it is better to take the entire daily dose at a time, shortly before physical activity.

The average duration of the course is from 6 to 8 weeks.

Best ALA supplements

Vitamin N is often used in sports, so you can buy alpha-lipoic acid not only in a pharmacy, but also in sports nutrition stores. Sports nutrition brands usually offer better value for money, and also feature higher dosages per serving. Among the most famous and popular ALA supplements are:

• NOW Alpha Lipoic Acid is the best choice for most situations. Includes packaging of 250 and 600 mg of the substance in each capsule. Differs in high quality and speed of assimilation of substance. Also has a favorable cost;

• Alpha Lipoic Acid by Solgar is an ALA from one of the most reputable supplement manufacturers in the world.