Tips for Managing & Living With Sickle Cell Disease

Written by WebMD Editorial Contributors

• Dealing With Pain
• Helpful Things
• Harmful Things
• How to Help a Loved One
• Mental Health Support
• When to Get Medical Care
• More

You can live a full, active life when you have sickle cell disease. You can take part in most of the same activities as other people. Making smart choices is important in keeping the condition from flaring into a crisis.

Sickle cell disease (SCD) is an inherited disorder in which the shape of red blood cells are C-shaped sickles that can get stuck in blood vessels and block them. This blockage is called a pain crisis or sickle crisis.

You won’t have total control over how SCD affects your body. But you can take steps to manage pain and to reduce your chances of problems.

SCD varies widely person to person. The severity of pain can range from mild to severe. Likewise, the methods to relieve it also can differ. Here are some good guidelines to follow:

• Talk with your doctor. Discuss your symptoms and find ways to relieve your pain. This may include medicine and other relief methods, including heating pads or physical therapy.
• Use pain medicines with caution. Talk with your doctor about what over-the-counter drugs are best for you. Some medication, such as ibuprofen (Advil, Motrin) or naproxen sodium (Aleve), may affect your kidneys.
• Look for pain triggers. Every time you’re in sudden pain, try to figure out what may have caused it. Although it’s not obvious at first, having a long-running list over time could help you find a link.
• Find what works for you. There isn’t one pain relief that works for everybody. You may have to try different things, such as a warm bath, a massage, or acupuncture. Also, do the things that help you relax, like listening to music or hanging out with friends.

SCD is a complex disease, so it’s important to see your doctor for regular health checkups. They could help you cut down the number of problems that may need urgent medical care. The goal is to avoid pain crises (vaso occlusive episodes) and acute chest syndrome (vaso-occlusive episodes in the lung specifically). Here are some other ways to take care of yourself:

• Drink plenty of fluids. Being dehydrated can increase your risk of a sickle crisis, so get plenty of water — about 8 glasses a day. Drink more fluid if you’re exercising or in hot weather.
• Sleep. Get enough.
• Eat right. Have plenty of fruits, vegetables, whole grains, and protein.
• Exercise in moderation. Aim for about 2½ hours of moderate exercise a week, such as walking or biking. Talk with your doctor before starting a new exercise routine. Physical activity is key in staying healthy. At the same time, you don’t want to overdo it. Rest when you get tired.
• Take your medicine. Make sure you take your prescription medicine as directed. Get medical and lab tests that your doctor recommends.
• Stay up to date on vaccines. It is critically important to get all recommended vaccines, including the annual flu shot, and pneumococcal and meningococcal vaccines. Common illnesses, like the flu, can quickly become dangerous if you have SCD. You are also more likely to get certain infections because most people with sickle cell don’t have a functional spleen–which is important for protection from certain infections.

• Extreme temperatures. Extreme heat or cold, or any swift changes in temperatures, could set off a crisis.
• High altitude. Lack of oxygen at high altitudes could trigger a crisis. (Planes, because they’re pressurized, shouldn’t be a problem).
• Alcohol. It can make you dehydrated.
• Smoking. This can trigger a lung condition called acute chest syndrome. This is when sickle cells stick together and block oxygen from getting into your lungs. It can also lead to a pain crises when the low oxygen causes sickling and vaso-occlusion.
• Infections. Common illnesses can be very serious for people with SCD. Wash your hands before eating or after using the bathroom. Wash your fruits and veggies, and avoid raw meat, eggs, and unpasteurized milk.
• Stress. It’s hard to avoid, but stress can trigger a crisis, so try to take time to relax or find techniques that help you calm down.
• Heavy physical labor. Though it’s good to get moderate exercise, very intense activities that are exhausting or leave you out of breath should be avoided.

If your loved one has SCD, you want to help the person to enjoy a normal life. Here are ways you can provide support:

• Detect signs of crisis. You may be able to tell when your loved one is about to have a sickle cell crisis. Knowing the signs can help you deal with crises quickly or perhaps keep them from happening again.
• Provide a support system. Be alert to symptoms, be prepared, and make allowances when necessary (especially for children) when SCD effects crop up.
• Help with pain relief. Take an active role in easing pain. This could mean giving a massage, finding a heat pad, or applying bandages. You could help your loved one with breathing exercises or other diversions to help the person relax.
• Reach out to support services. Parents of children with SCD have support groups that you may think about joining. There are also social workers and mental health clinicians that can help families deal with the diagnosis.
• Keep your child’s teachers informed. Make sure that teachers, day care workers and other adults who are entrusted with your child’s care know why they may need more frequent water breaks, bathroom breaks, and other issues. The CDC has published a booklet for teachers on how to help students who have sickle cell disease.

SCD is a lifelong disease. It’s normal for people with a chronic (ongoing) disease to feel sad at times, but if these feelings don’t go away and bother you to the point you’re thinking of harming yourself, get medical care at once.

Sickle cell groups and clinics can counsel you and connect you with support groups with people who are facing similar situations.

Keep an eye out for possible problems caused by SCD. If you have any of the following problems, get medical attention right away:

• Fever of 101 F or higher
• Chest pain
• Severe pain that you can’t soothe
• Severe headache, dizziness or stiff neck
• Seizure
• Swelling in your belly
• Loss of feeling or movement
• For men, a painful erection that lasts more than 4 hours
• Problems breathing
• Sudden loss of vision

Top Picks

Tips for Managing & Living With Sickle Cell Disease

Written by WebMD Editorial Contributors

• Dealing With Pain
• Helpful Things
• Harmful Things
• How to Help a Loved One
• Mental Health Support
• When to Get Medical Care
• More

You can live a full, active life when you have sickle cell disease. You can take part in most of the same activities as other people. Making smart choices is important in keeping the condition from flaring into a crisis.

Sickle cell disease (SCD) is an inherited disorder in which the shape of red blood cells are C-shaped sickles that can get stuck in blood vessels and block them. This blockage is called a pain crisis or sickle crisis.

You won’t have total control over how SCD affects your body. But you can take steps to manage pain and to reduce your chances of problems.

SCD varies widely person to person. The severity of pain can range from mild to severe. Likewise, the methods to relieve it also can differ. Here are some good guidelines to follow:

• Talk with your doctor. Discuss your symptoms and find ways to relieve your pain. This may include medicine and other relief methods, including heating pads or physical therapy.
• Use pain medicines with caution. Talk with your doctor about what over-the-counter drugs are best for you. Some medication, such as ibuprofen (Advil, Motrin) or naproxen sodium (Aleve), may affect your kidneys.
• Look for pain triggers. Every time you’re in sudden pain, try to figure out what may have caused it. Although it’s not obvious at first, having a long-running list over time could help you find a link.
• Find what works for you. There isn’t one pain relief that works for everybody. You may have to try different things, such as a warm bath, a massage, or acupuncture. Also, do the things that help you relax, like listening to music or hanging out with friends.

SCD is a complex disease, so it’s important to see your doctor for regular health checkups. They could help you cut down the number of problems that may need urgent medical care. The goal is to avoid pain crises (vaso occlusive episodes) and acute chest syndrome (vaso-occlusive episodes in the lung specifically). Here are some other ways to take care of yourself:

• Drink plenty of fluids. Being dehydrated can increase your risk of a sickle crisis, so get plenty of water — about 8 glasses a day. Drink more fluid if you’re exercising or in hot weather.
• Sleep. Get enough.
• Eat right. Have plenty of fruits, vegetables, whole grains, and protein.
• Exercise in moderation. Aim for about 2½ hours of moderate exercise a week, such as walking or biking. Talk with your doctor before starting a new exercise routine. Physical activity is key in staying healthy. At the same time, you don’t want to overdo it. Rest when you get tired.
• Take your medicine. Make sure you take your prescription medicine as directed. Get medical and lab tests that your doctor recommends.
• Stay up to date on vaccines. It is critically important to get all recommended vaccines, including the annual flu shot, and pneumococcal and meningococcal vaccines. Common illnesses, like the flu, can quickly become dangerous if you have SCD. You are also more likely to get certain infections because most people with sickle cell don’t have a functional spleen–which is important for protection from certain infections.

• Extreme temperatures. Extreme heat or cold, or any swift changes in temperatures, could set off a crisis.
• High altitude. Lack of oxygen at high altitudes could trigger a crisis. (Planes, because they’re pressurized, shouldn’t be a problem).
• Alcohol. It can make you dehydrated.
• Smoking. This can trigger a lung condition called acute chest syndrome. This is when sickle cells stick together and block oxygen from getting into your lungs. It can also lead to a pain crises when the low oxygen causes sickling and vaso-occlusion.
• Infections. Common illnesses can be very serious for people with SCD. Wash your hands before eating or after using the bathroom. Wash your fruits and veggies, and avoid raw meat, eggs, and unpasteurized milk.
• Stress. It’s hard to avoid, but stress can trigger a crisis, so try to take time to relax or find techniques that help you calm down.
• Heavy physical labor. Though it’s good to get moderate exercise, very intense activities that are exhausting or leave you out of breath should be avoided.

If your loved one has SCD, you want to help the person to enjoy a normal life. Here are ways you can provide support:

• Detect signs of crisis. You may be able to tell when your loved one is about to have a sickle cell crisis. Knowing the signs can help you deal with crises quickly or perhaps keep them from happening again.
• Provide a support system. Be alert to symptoms, be prepared, and make allowances when necessary (especially for children) when SCD effects crop up.
• Help with pain relief. Take an active role in easing pain. This could mean giving a massage, finding a heat pad, or applying bandages. You could help your loved one with breathing exercises or other diversions to help the person relax.
• Reach out to support services. Parents of children with SCD have support groups that you may think about joining. There are also social workers and mental health clinicians that can help families deal with the diagnosis.
• Keep your child’s teachers informed. Make sure that teachers, day care workers and other adults who are entrusted with your child’s care know why they may need more frequent water breaks, bathroom breaks, and other issues. The CDC has published a booklet for teachers on how to help students who have sickle cell disease.

SCD is a lifelong disease. It’s normal for people with a chronic (ongoing) disease to feel sad at times, but if these feelings don’t go away and bother you to the point you’re thinking of harming yourself, get medical care at once.

Sickle cell groups and clinics can counsel you and connect you with support groups with people who are facing similar situations.

Keep an eye out for possible problems caused by SCD. If you have any of the following problems, get medical attention right away:

• Fever of 101 F or higher
• Chest pain
• Severe pain that you can’t soothe
• Severe headache, dizziness or stiff neck
• Seizure
• Swelling in your belly
• Loss of feeling or movement
• For men, a painful erection that lasts more than 4 hours
• Problems breathing
• Sudden loss of vision

Top Picks

Rare Wolbachia genotypes in laboratory lines of Drosophila melanogaster | Ryabinin

1. Arnold P.A., Levin S.C., Stevanovic A.L., Johnson K.N. Drosophila melanogaster infected with Wolbachia strain wMelCS prefer cooler temperatures. ecol. Entomol. 2019;44(2):287-290. DOI 10.1111/een.12696.

2. Burdina E.V., Bykov R.A., Menshanov P.N., Ilinsky Y.Y., Gruntenko N.E. Unique Wolbachia strain wMelPlus increases heat stress resistance in Drosophila melanogaster. Arch. Insect Biochem. physiol. 2021;106(4):e21776. DOI 10.1002/arch.21776.

3. Bykov R.A., Ilinskii Yu.Yu., Voloshina M.A., Zakharov I.K. Prevalence and genotypic diversity of the symbiotic bacterium Wolbachia in the Drosophila melanogaster population of Nalchik. Russ. J. Genet. Appl. Res. 2014;4:539-542. https://doi.org/10.1134/S2079059714060057.

4. Bykov R.A., Yudina M.A., Gruntenko N.E., Zakharov I.K., Voloshina M.A., Melashchenko E.S., Danilova M.V., Mazunin I.O., Ilinsky Y.Y. Prevalence and genetic diversity of Wolbachia endosymbiont and mtDNA in Palearctic populations of Drosophila melanogaster. BMW Evol. Biol. 2019;19(1):45-53. DOI 10.1186/s12862-019-1372-9.

5. Chrostek E., Marialva M.S., Esteves S.S., Weinert L.A., Martinez J., Jiggins F.M., Teixeira L. Wolbachia variants induce differential protection to viruses in Drosophila melanogaster: a phenotypic and phylogenomic analysis. PLoS Genet. 2013;9(12):e1003896. DOI 10.1371/journal.pgen.1003896.

6. Clark M.E., Anderson C.L., Cande J., Karr T.L. Widespread prevalence of Wolbachia in laboratory stocks and the implications for Drosophila research. genetics. 2005;170(4):1667-1675. DOI 10.1534/genetics.104.038901.

7. Early A.M., Clark A.G. Monophyly of Wolbachia pipientis genomes within Drosophila melanogaster: geographic structuring, titre variation and host effects across five populations. Mol. ecol. 2013; 22(23):5765-5778. DOI 10.1111/mec.12530.

8. Flores H.A., Taneja de Bruyne J., O’Donnell T.B., Tuyet Nhu V., Thi Giang N., Thi Xuan Trang H., … Thi Hue Kien D., Thuy Vi T., Willis B., O’Neill S. L., Simmons C.P., Carrington L.B. Multiple Wolbachia strains provide comparative levels of protection against dengue virus infection in Aedes aegypti. PLoS Pathog. 2020;16(4): e1008433. DOI 10.1371/journal.ppat.1008433.

Various Wolbachia genotypes differently influence host Drosophila dopamine metabolism and survival under heat stress conditions. BMW Evol. Biol. 2017;17(2):15-22. DOI 10.1186/s12862-017-1104-y.

10. Hedges L.M., Brownlie J.C., O’Neill S.L., Johnson K.N. Wolbachia and virus protection in insects. Science. 2008;322(5902):702. DOI 10.1126/science.1162418.

11. Hoffmann A.A., Clancy D.J., Merton E. Cytoplasmic incompatibility in Australian populations of Drosophila melanogaster. genetics. 1994; 136(3):993-999. DOI 10.1093/genetics/136.3.993.

12. Hoffmann A.A., Hercus M., Dagher H. Population dynamics of the Wolbachia infection causing cytoplasmic incompatibility in Drosophila melanogaster. genetics. 1998;148(1):221-231. DOI 10.1093/genetics/148. 1.221.

13. Ilinsky Y. Coevolution of Drosophila melanogaster mtDNA and Wolbachia genotypes. PLOS One. 2013;8(1):e54373. DOI 10.1371/journal.pone.0054373.

14. Ilinsky Y.Y., Bykov R.A., Zakharov I.K. Cytotypes of mutant Drosophila melanogaster stocks from the collection of the genetics of population laboratory of the Institute of Cytology and Genetics SB RAS: genotypes of the Wolbachia endosymbiont and host mitotypes. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2014;17(3):404-423. (in English)

15. Ilinsky Yu.Yu., Zakharov I.K. The endosymbiont Wolbachia in Eurasian populations of Drosophila melanogaster. Russ. J. Genet. 2007a;43(7):748-756. DOI 10.1134/S102279540707006X.

16. Ilinsky Yu.Yu., Zakharov I.K. Infection of the Uman’ population of Drosophila melanogaster with the cytoplasmic endosymbiont Wolbachia. Dokl. Biol. sci. 2007b;413(1):166-168. DOI 10.1134/S0012496607020238.

17. Ilinsky Yu.Yu., Zakharov I. K. Cytoplasmic incompatibility in Drosophila melanogaster is caused by different Wolbachia genotypes. Russ. J. Genet. Appl. Res. 2011;1(5):458-462. DOI 10.1134/S2079059711020031.

18. Kriesner P., Conner W.R., Weeks A.R., Turelli M., Hoffmann A.A. Persistence of a Wolbachia infection frequency cline in Drosophila melanogaster and the possible role of reproductive dormancy. evolution. 2016;70(5):979-997. DOI 10.1111/evo.12923.

19. Mazzucco R., Nolte V., Vijayan T., Schlötterer C. Long-term dynamics among Wolbachia strains during thermal adaptation of their Drosophila melanogaster hosts. front. Genet. 2020;11:482. DOI 10.3389/fgene.2020.00482.

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21. Richardson M.F., Weinert L.A., Welch J.J., Linheiro R.S., Magwire M.M., Jiggins F.M., Bergman C.M. Population genomics of the Wolbachia endosymbiont in Drosophila melanogaster. PLoS Genet. 2012;8(12):e1003129. DOI 10.1371/journal.pgen.1003129.

22. Riegler M., Sidhu M., Miller W.J., O’Neill S.L. Evidence for a global Wolbachia replacement in Drosophila melanogaster. Curr. Biol. 2005;15(15):1428-1433. DOI 10.1016/j.cub.2005.06.069.

23. Schultz M.J., Isern S., Michael S.F., Corley R.B., Connor J.H., Frydman H.M. Variable inhibition of Zika virus replication by different Wolbachia strains in mosquito cell cultures. J. Virol. 2017;91(14): e00339-17. DOI 10.1128/JVI.00339-17.

24. Serga S., Maistrenko O., Rozhok A., Mousseau T., Kozeretska I. Fecundity as one of possible factors contributing to the dominance of the wMel genotype of Wolbachia in natural populations of Drosophila melanogaster. Symbiosis. 2014;63(1):11-17. DOI 10.1007/s13199-014-0283-1.

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30. Xue L., Fang X., Hyman J.M. Comparing the effectiveness of different strains of Wolbachia for controlling chikungunya, dengue fever, and Zika. PLOS Negl. Trop. Dis. 2018;12(7):e0006666. DOI 10.1371/journal.pntd.0006666.

Ryazan State Medical University named after Academician I.P. Pavlov



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05/30/2023

Admission Campaign – 2023

On our website in the section Home / Applicants / Applicants (specialist / bachelor / master) there is a video that details the rules for admission to Ryazan State Medical University.

05/25/2023

Intensive courses to prepare for entrance examinations
We invite you, dear applicants, to take intensive courses to prepare for the entrance exams, conducted by the university itself.

05/18/2023

About the recovery in the number of students
Commission for the restoration of the number of university students will be held on 09June 2023 (Friday) from 10.00 at the address: st. Vysokovoltnaya, 9, educational and laboratory building, 3rd floor, office No. 302.

06/07/2023

Ryazan State Medical University starts screening the population of the region for orphan pathology
Laboratory and research capabilities of the Ryazan State Medical University will allow screening for the detection of a rare genetic disease.

06/07/2023

RyazGMU in the RAEX-100 rating showed dynamics in 4 indicators
In the published ranking of the best universities in Russia, Ryazan State Medical University ranks 9place among medical schools.

ratings

06/07/2023

To help means to be needed!
The rector of the Ryazan State Medical University Kalinin Roman Evgenievich was thanked for the effective interaction and support of initiatives in protecting the rights of children and families in the Ryazan region, for organizing educational volunteer and sports activities in the field of childhood.

06/06/2023

Enter the residency of RyazGMU
Graduate students met with the rector at the meeting, the topic of which was admission to the residency of the Ryazan State Medical University.

06/06/2023

The most erudite schoolchildren gathered in the Ryazan State Medical University
On the basis of the Education Development Center of the Ryazan State Medical University, the regional stage of the country’s largest intellectual tournament “League of Knowledge: Schools and Colleges” was held.

06/06/2023

Sport. Victory. Achievements
Students and staff of RyazGMU took part in several sports competitions.

06/05/2023

Social mission of RyazGMU
– The university is ready and, in fact, is already included in the project aimed at helping children with rare diseases and, in general, the families in which they are brought up, – said the rector of the RyazGMU Roman Evgenievich Kalinin. – We are talking about improving the program for training pediatricians, as well as the provision of psychological assistance on the basis of the Faculty of Clinical Psychology to parents who are faced with a difficult psycho-emotional situation. And, of course, we can become the basis for teaching parents the correct use of rehabilitation facilities that will be provided to them by decision of our President.

News

14.02.2023

TELL YOU WHO IS ALREADY AVAILABLE ONLINE TUITION PAYMENT IN RYAZGMU

Now all students of the FDPO RyazGMU can pay for training without leaving their homes. You can pay online and without commission using the new service pay.rzgmu.ru

09/23/2022

News FDPO RyazGMU

04/04/2023

Course “PSYCHOLOGICAL METHODS OF WORK WITH THE CONSEQUENCES OF PSYCHOTRAUFUL EVENTS”
Additional professional advanced training program “Psychological methods of working with the consequences of traumatic events” was developed for specialists with a psychological education.

02/28/2023

SWIMMING IN THE MEDICAL SENSE IS USEFUL FOR ABSOLUTELY EVERYONE
Why – says Valery Grigorievich Demikhov, Doctor of Medical Sciences, Professor, Director of the Scientific and Clinical Center for Hematology, Oncology and Immunology, Ryazan State Medical University of the Ministry of Health of Russia

22.02.2023

DEPARTURE TO THE NOVOMOSKOVSK CITY CLINICAL HOSPITAL
On February 16, a visit to the State Healthcare Institution “Novomoskovsk City Clinical Hospital” took place. On behalf of the Ministry of Health of the Tula region, tests were prepared to assess the knowledge of obstetrician-gynecologists. Head of the Department of Obstetrics and Gynecology of the Ryazan State Medical University Kovalenko M.S. and Dean of the FDPO RyazGMU Maksimtseva E.A. tested 21 specialists of the State Healthcare Institution “NGCH” and conducted a clinical tour of the departments of branch No. 2 of the State Health Institution “NGCH” together with the Deputy Chief Physician for Obstetrics and Gynecology Breus E.V. and department staff.

22.02.2023

TRAINING UNDER THE PROGRAM “NURSING IN PEDIATRICS” IS COMPLETED
On February 16, the 144-hour advanced training program “Nursing in Pediatrics” ended. During the training, nurses in the Ryazan region improved their knowledge and skills in nursing care for a healthy and sick child with infectious and somatic pathology, prevention of somatic and infectious pathology in childhood in accordance with the regulatory framework, professional standards and clinical recommendations.

02/16/2023

WetLab

02/14/2023

BASIC EMERGENCY FIRST AID COURSE

02/14/2023

COURSE “METHODS OF NON-TEST PSYCHODIAGNOSIS OF PERSONALITY”

27.09.2022

Russian as a foreign language (speech practice course)

FDPO

06/02/2023

I Congress of Therapists of the Central Federal District

On June 8-9, Ryazan State Medical University will host a forum aimed at practical healthcare professionals. The organizers are RNMOT, the Ministry of Health of the Ryazan Region and the Ryazan State Medical University.

06/02/2023

In June, the second cycle of training “Fundamentals of Kinesiology Taping” starts
The cycle is intended for everyone, regardless of the presence or absence of a medical education. Listeners have the opportunity to get or improve the skill of using elastic bands, to learn everything or almost everything about teips!

29.05.2023

Physical and Rehabilitation Medicine in Pediatrics
On June 3, 2023, the University will host the Interregional Scientific and Practical Conference “Physical and Rehabilitation Medicine in Pediatrics”. Beginning at 10.00 in the hall of the Academic Council, at the address: Ryazan, st. Vysokovoltnaya, d. 7, bldg. 1, 4th floor.

05/25/2023

Mental health service: achievements and prospects
We invite you to take part in the IX Interregional Scientific and Practical Conference “Mental Health Service: Achievements and Prospects. Dedicated to the 135th anniversary of the Ryazan Regional Clinical Psychiatric Hospital. N.N. Bazhenov”, which will be held on June 2, 2023 on the basis of the Ryazan Regional Clinical Psychiatric Hospital. Bazhenova N.N.

05/22/2023

WE INVITE YOU TO READ THE PROGRAM OF THE CONFERENCE “TOPICAL ISSUES OF THERAPY AND GENERAL MEDICAL PRACTICE”

05/18/2023

To the attention of graduates, students and residents!
The annual large-scale event at the Ryazan Medical University – Job Fair 2023 – will be held on Tuesday, May 23 at 11 am in the foyer of the first and second floors of the medical and preventive building (Vysokovoltnaya st. , 7 building 1)!

05/17/2023

WE INVITE YOU TO JOIN THE ONLINE CONFERENCE
Dear Colleagues! 18 and 19May, the online conference “Psychological Research of Appearance and Body Image” is held by the Department of Clinical Psychology

05/17/2023

Day of the Lipetsk region in the Ryazan State Medical University
We invite graduates and students on May 18 to the Center for Culture and Leisure of the University for the “Day of the Lipetsk Region”.

05/16/2023

May 17 – World Hypertension Day
In the clinical divisions of the Ryazan State Medical University, as well as on the territory of the medical campus, from 12.