Short-Term Red Wine Consumption Promotes Differential Effects on Plasma Levels of High-Density Lipoprotein Cholesterol, Sympathetic Activity, and Endothelial Function in Hypercholesterolemic, Hypertensive, and Healthy Subjects

1. da Luz PL, Coimbra SR. Wine, alcohol and atherosclerosis: clinical evidences and mechanisms. Braz J Med Biol Res. 2004;37:1275–95. [PubMed] [Google Scholar]

2. Klatsky AL, Friedman GD, Armstrong MA, Kipp H. Wine, liquor, beer, and mortality. Am J Epidemiol. 2003;158:585–95. [PubMed] [Google Scholar]

3. Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J. 2007;28:1683–93. [PubMed] [Google Scholar]

4. Nishiwaki M, Ishikawa T, Ito T, Shige H, Tomiyasu K, Nakajima K, et al. Effects of alcohol on lipoprotein lipase, hepatic lipase, cholesteryl ester transfer protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation. Atherosclerosis. 1994;111:99–109. [PubMed] [Google Scholar]

5. Ruf JC. Alcohol, wine and platelet function. Biol Res. 2004;37:209–15. [PubMed] [Google Scholar]

6. Durak I, Avci A, Kaçmaz M, Büyükkoçak S, Cimen MY, Elgün S, et al. Comparison of antioxidant potentials of red wine, white wine, grape juice and alcohol. Curr Med Res Opin. 1999;15:316–20. [PubMed] [Google Scholar]

7. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation. 1999;100:1050–55. [PubMed] [Google Scholar]

8. Coimbra SR, Lage SH, Brandizzi L, Yoshida V, da Luz PL. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz J Med Biol Res. 2005;38:1339–47. [PubMed] [Google Scholar]

9. Zilkens RR, Burke V, Hodgson JM, Barden A, Beilin LJ, Puddey IB. Red wine and beer elevate blood pressure in normotensive men. Hypertension. 2005;45:874–9. [PubMed] [Google Scholar]

10. McFadden CB, Brensinger CM, Berlin JA, Townsend RR. Systematic review of the effect of daily alcohol intake on blood pressure. Am J Hypertens. 2005;18:276–86. [PubMed] [Google Scholar]

11. Grassi GM, Somers VK, Renk WS, Abboud FM, Mark AL. Effects of alcohol intake on blood pressure and sympathetic nerve activity in normotensive humans: a preliminary report. J Hypertens. Suppl. 1989;7:S20–1. [PubMed] [Google Scholar]

12. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–52. [PubMed] [Google Scholar]

13. Delius W, Hagbarth KE, Hongell A, Wallin BG. General characteristics of sympathetic activity in human muscle nerves. Acta Physiol Scand. 1972;84:65–81. [PubMed] [Google Scholar]

14. Harms MP, Wesseling KH, Pott F, Jenstrup M, Van Goudoever J, Secher NH, et al. Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress. Clin Sci (Lond) 1999;97:291–301. [PubMed] [Google Scholar]

15. Imholz BP, Wieling W, van Montfrans GA, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res. 1998;38:605–16. [PubMed] [Google Scholar]

16. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, et al. International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–65. [PubMed] [Google Scholar]

17. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999;319:1523–8. [PMC free article] [PubMed] [Google Scholar]

18. Lopes HF, Consolim-Colombo FM, Barreto-Filho JA, Riccio GM, Negrão CE, Krieger EM. Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents. Braz J Med Biol Res. 2008;41:849–53. [PubMed] [Google Scholar]

19. Penna GL, Garbero R de F, Neves MF, Oigman W, Bottino DA, Bouskela E. Treatment of essential hypertension does not normalize capillary rarefaction. Clinics. 2008;63:613–8. [PMC free article] [PubMed] [Google Scholar]

20. Crisostomo LM, Souza CA, Mendes CM, Coimbra SR, Favarato D, Luz PL. Vascular and metabolic response to statin in the mildly hypertensive hypercholesterolemic elderly. metabolic response to statin in the mildly hypertensive hypercholesterolemic elderly. Clinics. 2008;63:589–94. [PMC free article] [PubMed] [Google Scholar]

21. Luz PL, Favarato D, Faria-Neto JR, Jr, Lemos P, Chagas AC. High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease. Clinics. 2008;63:427–32. [PMC free article] [PubMed] [Google Scholar]

22. Hansen AS, Marckmann P, Dragsted LO, Finné Nielsen IL, Nielsen SE, Grønbaek M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur J Clin Nutr. 2005;59:449–55. [PubMed] [Google Scholar]

23. Hagiage M, Marti C, Rigaud D, Senault C, Fumeron F, Apfelbaum M, et al. Effect of a moderate alcohol intake on the lipoproteins of normotriglyceridemic obese subjects compared with normoponderal controls. Metabolism. 1992;41:856–61. [PubMed] [Google Scholar]

24. Kiechl S, Willeit J, Poewe W, Egger G, Oberhollenzer F, Muggeo M, et al. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study) BMJ. 1996;313:1040–4. [PMC free article] [PubMed] [Google Scholar]

25. Freiberg MS, Cabral HJ, Heeren TC, Vasan RS, Curtis Ellison R, Third National Health and Nutrition Examination Survey Alcohol consumption and the prevalence of the Metabolic Syndrome in the US: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27:2954–9. [PubMed] [Google Scholar]

26. Beulens JW, Rimm EB, Hu FB, Hendriks HF, Mukamal KJ. Alcohol consumption, mediating biomarkers and risk of type 2 diabetes among middle-aged women. Diabetes Care. 2008;31:2050–5. [PMC free article] [PubMed] [Google Scholar]

27. van de Borne P, Mark AL, Montano N, Mion D, Somers VK. Effects of alcohol on sympathetic activity, hemodynamics, and chemoreflex sensitivity. Hypertension. 1997;29:1278–83. [PubMed] [Google Scholar]

28. Spaak J, Merlocco AC, Soleas GJ, Tomlinson G, Morris BL, Picton P, et al. Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. Am J Physiol Heart Circ Physiol. 2008;294:H605–12. [PubMed] [Google Scholar]

29. Skrapari I, Tentolouris N, Katsilambros N. Baroreflex function: determinants in healthy subjects and disturbances in diabetes, obesity and metabolic syndrome. Curr Diabetes Ver. 2006;2:329–38. [PubMed] [Google Scholar]

30. Abdel-Rahman AA, Wooles WR. Ethanol-induced hypertension involves impairment of baroreceptors. Hypertension. 1987;10:67–73. [PubMed] [Google Scholar]

31. Whelan AP, Sutherland WH, McCormick MP, Yeoman DJ, de Jong SA, Williams MJ. Effects of white and red wine on endothelial function in subjects with coronary artery disease. Intern Med J. 2004;34:224–8. [PubMed] [Google Scholar]

32. Karatzi K, Papamichael C, Aznaouridis K, Karatzis E, Lekakis J, Matsouka C, et al. Constituents of red wine other than alcohol improve endothelial function in patients with coronary artery disease. Coron Artery Dis. 2004;15:485–90. [PubMed] [Google Scholar]

33. Andriambeloson E, Stoclet JC, Andriantsitohaina R. Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol. 1999;33:248–54. [PubMed] [Google Scholar]

34. Puddey IB, Zilkens RR, Croft KD, Beilin LJ. Alcohol and endothelial function: a brief review. Clin Exp Pharmacol Physiol. 2001;28:1020–4. [PubMed] [Google Scholar]

35. Münzel T, Sinning C, Post F, Warnholtz A, Schulz E. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann Med. 2008;40:180–96. [PubMed] [Google Scholar]

36. Gilligan DM, Guetta V, Panza JA, García CE, Quyyumi AA, Cannon RO., 3rd Selective loss of microvascular endothelial function in human hypercholesterolemia. Circulation. 1994;90:35–41. [PubMed] [Google Scholar]

37. Panza JA, García CE, Kilcoyne CM, Quyyumi AA, Cannon RO., 3rd Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation. 1995;91:1732–8. [PubMed] [Google Scholar]

Drinking red wine for heart health? Read this before you toast

Please note: This article was published more than two years ago, so some information may be outdated. If you have questions about your health, always contact a health care professional.

(Mark Hodgson, Getty Images)

For years, studies have shown a relationship between drinking a moderate amount of red wine and good heart health, but experts say it’s important to understand what that means before you prescribe yourself a glass or two a day.

No research has established a cause-and-effect link between drinking alcohol and better heart health. Rather, studies have found an association between wine and such benefits as a lower risk of dying from heart disease.

It’s unclear whether red wine is directly associated with this benefit or whether other factors are at play, said Dr. Robert Kloner, chief science officer and director of cardiovascular research at Huntington Medical Research Institutes and a professor of medicine at the University of Southern California.

“It might be that wine drinkers are more likely to have a healthier lifestyle and a healthier diet such as the Mediterranean diet, which is known to be cardioprotective,” he said.

But you may not even have to drink red wine to get the benefit, Kloner said. Moderate amounts of beer and spirits also have been linked to a lower risk of heart disease.

It’s a common assumption that red wine may be good for the heart because it contains antioxidants such as resveratrol, which is primarily found in the skin of grapes but also peanuts and blueberries. Some studies suggest resveratrol can reduce cholesterol and lower blood pressure.

“There’s a debate about whether resveratrol is really cardioprotective or not,” Kloner said. “In addition, there is debate about the amount of resveratrol you would need to ingest to get a protective effect. To get the equivalent of the amount of resveratrol that has been reported to be protective would probably mean ingesting an excess of wine.”

Federal guidelines and the American Heart Association recommend that if you do drink alcohol, to do so in moderation. That means no more than one to two drinks per day for men and one drink per day for women. (According to the AHA, one drink is 12 ounces of beer, 4 ounces of wine, 1.5 ounces of 80-proof spirits or 1 ounce of 100-proof spirits.)

Studies have found that moderate alcohol consumption may have some health benefits, including raising “good” HDL cholesterol levels and lowering the risk of diabetes. However, excessive drinking can lead to a host of health problems, including liver damage, obesity, some types of cancer and stroke, not to mention its negative effect on the heart.

“Alcohol in excess is really bad for the heart,” Kloner said. “It can cause high blood pressure and promote arrhythmias. It can cause cardiomyopathy where the alcohol is actually toxic to the heart muscle cells, and that can lead to heart failure.”

Proving moderate alcohol use causes better heart health would be tricky, Kloner said. Ideally, it would require a large prospective study that not only randomly assigns people to a no-drinking group versus a moderate-drinking group, but that also compares different types of alcohol – red wine, white wine, beer, spirits – to determine if one really is better.

“And then you’d have to control for various factors – age, gender, cardiovascular risk, their diet. You’d have to follow them for many years,” he said, noting the added ethical dilemma of taking people who are not drinkers and telling them to become drinkers.

For now, the message certainly isn’t to go out and start drinking, Kloner said. “But if you do drink, drinking in moderation is the way to go.”

If you have questions or comments about this story, please email [email protected].

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Is there any benefit from wine – the benefits of drinking wine

Scientists and researchers have been talking about the health benefits of drinking wine for many years. The key to the health benefits of wine is, of course, moderation. Discover some of the many health benefits of wine.

Wine raises good cholesterol

Numerous studies show that wine, red or white, raises HDL cholesterol. HDL cholesterol is often referred to as “good” cholesterol. This type of cholesterol actually helps reduce the fat on the walls of your arteries by delivering it to your liver. The liver then processes these fats into waste and your body eliminates them.

Fighting free radicals

Free radicals are basically groups of atoms that attack healthy cells causing damage to cells. Antioxidants help counter the damage caused by free radicals. The flavanoids and resveratrol in wine act as antioxidants to fight free radical damage to cells.

Relieves anxiety

Wine acts as a mild natural sedative. One glass of wine of 150-200 grams helps relieve anxiety and tension. When stressed, the heart pumps blood faster and works harder, putting people with high levels of stress at increased risk of heart attacks and cardiovascular disease. The anti-anxiety effect of wine helps slow heart palpitations to a more normal, healthy level and lowers blood pressure. Scientists have proven that the antioxidants in wine slow down the development of arterial plaque. In this way, wine helps prevent arthrosis, thereby helping to slow down or prevent heart disease.

Ulcer Prevention

A 2003 study by the American Journal of Gastroenterology found that regular wine drinkers reduced their risk of developing ulcers by helping the body rid itself of the specific bacteria known to cause these ulcers. However, the study noted that wine consumption should be moderate, and excessive consumption leads to an increased risk of developing peptic ulcers.

Heart health

The heart experiences the many health benefits of wine. Along with the cholesterol and anti-anxiety benefits mentioned above, drinking wine moderately and regularly helps prevent a heart condition known as cardiac fibrosis. Cystic fibrosis of the heart occurs when proteins build up in the heart valves, causing them to thicken. With this thickening, the heart beats much less efficiently. Wine helps prevent the formation of these proteins inside the heart valves.

Wine as an anti-inflammatory agent

Regular and moderate wine consumption has anti-inflammatory properties.

Enhanced Lung Function

Another of the health benefits of wine is that flavonoids and other antioxidants have been shown to increase lung function, making them more efficient.

Protecting blood vessels

Polyphenolic compounds found in wine, known as procyanidins, help protect blood vessels from damage. They also work to protect the endothelium. The endothelium is the protective tissue around the heart and blood vessels.

Brain function

A 2006 preliminary study by the Federation of American Societies for Experimental Biology found that regular and moderate wine consumption can help slow memory loss and also prevent brain cell death. This reduces the risk of developing diseases associated with dementia and dementia, such as Alzheimer’s disease.

5 healthy reasons to agree to a glass of wine are named: against cholesterol

01/26/2022 at 20:37

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Disputes about the influence of a moderate amount of alcohol on the body, especially for women, have not subsided for a long time. Supporters of a healthy lifestyle are categorically against even small amounts of such “doping”. Some researchers, too, believing that even in small doses, alcohol can lead to irreversible changes in the body. On the other hand, opponents note that wine is part of the famous Mediterranean diet, which is considered one of the healthiest. Finally, since ancient times, the inhabitants of the Caucasus and Italy cannot imagine their life without wine, and at the same time they are distinguished by enviable longevity. Nutritionists agree that the truth, as always, is somewhere in between.

If we talk about dry wine and very limited quantities, there are still benefits from drinking it, concludes Harper’s Bazaar. The publication emphasizes that in this case we mean a daily portion equal to one glass. Also, we are talking about dry wine, since dessert wines have too much sugar.

The first positive thing from a glass of dry red wine at a meal is getting polyphenols, which have a beneficial effect on the heart vessels. The resveratrol contained in the skin of grapes, according to a number of studies, has a number of useful functions: it reduces “bad” cholesterol, protects blood vessels, reduces blood clots and has an anti-inflammatory effect, and also helps maintain bone strength. It is also believed that this substance helps to slightly reduce the risk of developing certain types of cancer, but these assumptions have not been confirmed.

Substances in red wine have an antioxidant effect, that is, they help slow down the aging process. Grapes contain many polyphenols and tannins, the concentration of which increases during fermentation. Antioxidants protect cells from damage by free radicals, therefore, slow down age-related changes in the cells of organs and skin. Red wine is also full of phytoestrogens, which stimulate the body’s production of collagen and hyaluronic acid.

The active ingredients in red wine also tone the nervous system by improving the blood supply to the brain. According to the observations of a number of researchers, the cumulative effect of red wine becomes the prevention of age-related memory degeneration and even Alzheimer’s disease.

The already mentioned polyphenols protect the body from chronic diseases by fighting inflammation. Also, the components of wine can increase the body’s susceptibility to insulin, which helps in the prevention of diabetes.

The fifth and very important positive effect of red wine is a good mood. This is not about the feeling of intoxication, but about the high content of fruit acids and tannins in this drink, which scientists associate with an increase in the general emotional background and even the prevention of depression. But there is an important note: such an “antidepressant” works only if no more than 1 glass is consumed per day. With an excess of alcohol on the face, the opposite effect is depression of the nervous system and health problems, in the presence of which the mood simply cannot be good.

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