Magnesium and Heart Health – Heart Health Center

What is the role of magnesium in heart health?

— Susan, Georgia

Magnesium has hundreds of important functions in the body, from energy production and proper nerve function to muscle relaxation. Studies are mixed about whether its potential heart benefits come from the magnesium itself or from a combination of magnesium and other beneficial nutrients (such as potassium and fiber). Or perhaps it’s simply that people who eat a magnesium-rich diet are more health conscious in general. But there is no question that this important mineral plays a key role in the prevention of cardiovascular disease. Here’s a crash course in what magnesium can do to help your heart:

Regulate heart rhythm. Just as it helps nerve function throughout the body, magnesium is important for coordinating the activity of the heart muscle and the nerves that initiate the heartbeat. If your magnesium levels are low, you are more likely to be at risk for arrhythmias (irregular heartbeats) and heart palpitations. While doctors can temporarily stabilize irregular heartbeats with injections of a magnesium compound, this is generally not done except in an emergency situation.

Prevent angina. Magnesium helps keep coronary arteries from having spasms, which is what causes the intense chest pain known as angina. In fact, a deficiency of magnesium is the most common cause of such arterial spasms.

Control high blood pressure. By relaxing the muscles that control blood vessels and allowing blood to flow more freely, magnesium may play a role in reducing elevated blood pressure, an important factor in decreasing the risk for heart attack and stroke. Magnesium’s effect on high blood pressure is further enhanced because it helps equalize the levels of potassium and sodium in the blood.

Limit complications of congestive heart failure. Because magnesium can help lower blood pressure and reduce the risk of arrhythmia, two frequent complications in those with congestive heart failure, a weakened heart may benefit from getting more of this mineral.

Reduce incidence of prediabetes and diabetes and improve insulin resistance. Several important studies have demonstrated that getting insufficient amounts of magnesium increases the risk of metabolic syndrome (prediabetes), type 1 and type 2 diabetes, and the development of diabetes complications. Moreover, a magnesium deficiency can negatively affect fasting blood glucose and insulin levels in nondiabetic individuals (which often leads to diabetes). I believe, however, that more research is needed on the role of magnesium in diabetes prevention.

Learn more in the Everyday Health Heart Health Center.

Got Magnesium? Those With Heart Disease Should

Nov. 9, 2000 — Every cell in the body needs magnesium. It helps keep muscles strong and nerves alert. And a new study in the journal Circulation suggests that daily magnesium supplements can even help an ailing heart.

Lead author C. Noel Bairey Merz, MD, tells WebMD that magnesium supplements enabled heart disease patients to exercise for longer periods and appeared to protect their hearts from the stress of exercise. Magnesium also restored some of the blood vessels’ ability to open up when the body needs more blood. Merz is director of the preventive and rehabilitative cardiac center at Cedars-Sinai Medical Center in Los Angeles.

Half of the patients in the study took a supplement containing 365 mg of magnesium twice a day for six months. The other half took a placebo. Merz tells WebMD that at the end of the study, the patients who took magnesium had better blood vessel function and their hearts showed less stress during treadmill exercise compared to the placebo group. Nearly three-quarters of the patients were magnesium-deficient at the beginning of the study, but their levels rose to nearly normal by the end.

So what is it about magnesium that makes it such a friend to the body? It could be that magnesium helps the body’s cells fend off stress. Magnesium-deficient cells also are more vulnerable to injury, and patients with heart disease may have greater need for magnesium, Merz says.

Carla A. Sueta, MD, PhD, who was not involved in the study, says, “we probably should move toward routine screening” for all patients with heart disease and offer supplements to all those found to be deficient. She cautions that the simple blood test available to doctors is not an accurate measure of magnesium levels. If the tests results are low, magnesium levels are probably very low in reality, so even someone with normal levels may still need supplements. Sueta is associate professor of medicine at the University of North Carolina at Chapel Hill, N.C.

Similar magnesium supplements are available over-the-counter in the U.S., but they might not provide similar benefits. “The product we used is from Germany, where supplements of this kind are regulated and quality is monitored,” Merz says. “Because that is not the case in the U.S., it is impossible to know what you are getting in a supplement, or even whether it contains any magnesium at all. Patients who decide to try magnesium supplements available in the U. S. are probably fairly safe unless they have kidney problems,” according to Merz.

However, he does suggest that people “follow the dietary recommendations to eat five to seven helpings of fruits or vegetables and two or three of nonfat dairy products every day. If everyone did that, we probably would not see the levels of magnesium deficiency we often find.”

The most important food sources of magnesium are green vegetables like spinach, nuts, seeds, and some whole grains.

The research was funded in part by Asta Medica Co. Inc., manufacturer of the magnesium supplements used in the study.

Oral magnesium therapy, exercise heart rate, exercise tolerance, and myocardial function in coronary artery disease patients

Abstract

Background: Previous studies have demonstrated that in patients with coronary artery disease (CAD) upward deflection of the heart rate (HR) performance curve can be observed and that this upward deflection and the degree of the deflection are correlated with a diminished stress dependent left ventricular function. Magnesium supplementation improves endothelial function, exercise tolerance, and exercise induced chest pain in patients with CAD.

Purpose: We studied the effects of oral magnesium therapy on exercise dependent HR as related to exercise tolerance and resting myocardial function in patients with CAD.

Methods: In a double blind controlled trial, 53 male patients with stable CAD were randomised to either oral magnesium 15 mmol twice daily (n = 28, age 61±9 years, height 171±7 cm, body weight 79±10 kg, previous myocardial infarction, n = 7) or placebo (n = 25, age 58±10 years, height 172±6 cm, body weight 79±10 kg, previous myocardial infarction, n = 6) for 6 months. Maximal oxygen uptake (VO_2max), the degree and direction of the deflection of the HR performance curve described as factor k<0 (upward deflection), and the left ventricular ejection fraction (LVEF) were the outcomes measured.

Results: Magnesium therapy for 6 months significantly increased intracellular magnesium levels (32. 7±2.5 v 35.6±2.1 mEq/l, p<0.001) compared to placebo (33.1±3.1.9 v 33.8±2.0 mEq/l, NS), VO_2max (28.3±6.2 v 30.6±7.1 ml/kg/min, p<0.001; 29.3±5.4 v 29.6±5.2 ml/kg/min, NS), factor k (−0.298±0.242 v −0.208±0.260, p<0.05; −0.269±0.336 v −0.272±0.335, NS), and LVEF (58±11 v 67±10%, p<0.001; 55±11 v 54±12%, NS).

Conclusion: The present study supports the intake of oral magnesium and its favourable effects on exercise tolerance and left ventricular function during rest and exercise in stable CAD patients.

• ANOVA, analysis of variance
• CAD, coronary artery disease
• 2D, two dimensional
• HR, heart rate
• HRPC, heart rate performance curve
• LA, blood lactate concentration
• LSD, least significant differences
• LTP, lactate turn point
• LVDD, left ventricular internal diameter during diastole
• LVEF, left ventricular ejection fraction
• LVSD, left ventricular internal diameter during systole
• [Mg]i, intracellular magnesium level
• P_max, maximum power
• SD, standard deviation

• echocardiography
• exercise
• heart rate performance curve
• magnesium

Magnesium for Heart Health – Hotze Health & Wellness Center

Comments: 2 | April 12th, 2017

Heart disease is the number one killer of women and men. When you think about preventing heart disease, cholesterol is probably the first thing that comes to mind. However, there is an important mineral essential to heart health that is often overlooked: magnesium.

What is magnesium?
Magnesium is a mineral that is needed for more than 300 biochemical reactions in the body. It helps to maintain normal nerve and muscle function, supports a healthy immune system, keeps the heartbeat steady, and helps bones remain strong. It also helps regulate blood glucose levels and aid in the production of energy and protein.

How does magnesium protect your heart?
Your heart can’t function properly without magnesium. Magnesium prevents muscle spasms of the heart blood vessels, which can lead to a high blood pressure and a heart attack. Magnesium prevents calcium buildup in cholesterol plaque in arteries, which leads to clogged arteries.

Research on How Optimal Magnesium Levels Affect Your Heart
Magnesium levels are inversely associated with cardiovascular disease risk.
Research shows that magnesium was associated with a 30% lower risk of cardiovascular disease and 22% lower risk of ischemic heart disease.(1)

Optimum tissue levels of magnesium and potassium are essential to the structure and function of the myocardium (muscular tissue of the heart).
Subjects dying suddenly with ischemic heart disease had significantly lower levels of myocardial tissue magnesium and potassium than the control group. (2)

Low magnesium was associated with higher prevalence of hypertension, type 2 diabetes, and coronary artery calcification.
The Genetics of Atherosclerotic Disease (GEA) Study showed that low magnesium was associated with higher prevalence of hypertension (high blood pressure), type 2 diabetes, and coronary artery calcification, which is a marker of atherosclerosis and a predictor of cardiovascular morbidity and mortality. Subjects with the highest magnesium had 48 % lower odds of hypertension, 69 % lower odds of type 2 diabetes, and 42 % lower odds of coronary artery calcification score compared to those with the lowest magnesium. The analyses also showed that an increment in magnesium was independently associated with 16 % lower coronary artery calcification. (3)

Magnesium intake is significantly and inversely associated with serum C-reactive protein levels.
C-reactive protein is a predictor of heart disease because it is an indicator of inflammation, and it is the inflammation and injury of the blood vessels that cause heart disease. (6) A meta-analysis review indicates that magnesium intake is significantly and inversely associated with serum C-reactive protein levels. The potential beneficial effect of magnesium intake on chronic diseases may be, in part, explained by inhibiting inflammation. (4)

Magnesium helps lower blood pressure.
It’s important to keep your blood pressure in check since it is a risk factor for heart disease. Magnesium has been used successfully to treat high blood pressure for over half a century by doctors. (5)

Causes of of Magnesium Deficiency
Most people are deficient in magnesium because foods such as caffeine and sugar deplete the body’s magnesium levels. Not eating enough green vegetables in your diet can also contribute to a deficiency since green vegetables contain magnesium. Chemicals like fluoride and chlorine in the water supply bind to magnesium so your body can’t use it. Medications such as antibiotics and diuretics deplete magnesium by impairing absorption or increasing excretion by the kidneys.

Symptoms of Magnesium Deficiency
Weak muscles
Muscle spasms
Muscle cramps
Muscle twitches
Irregular or rapid heartbeat
Irritability
Anxiety
High blood pressure
Asthma
Fatigue
Vertigo
Back aches
Depression
Headache
Loss of appetite
Sleep disorders
Nausea
Migraines
Seizures
Constipation
Osteoporosis
Insulin resistance

How to Test for a Magnesium Deficiency
It is possible to test for a magnesium deficiency and our doctors recommend obtaining the red blood cell magnesium level. It may be listed by the lab as RBC Mg or Mg RBC. A level of 6 or more is optimal.

How to Optimize Your Magnesium Levels
We must get magnesium through food, supplements or topical applications. Foods rich in magnesium are spinach, broccoli, Brussels sprouts, avocados, romaine lettuce, kale, Swiss chard, turnip greens, collard greens, bok choy, salmon, mackerel, squash, papaya, raspberries, tomato, strawberries, and watermelon. Seeds and nuts have magnesium, with pumpkin, sesame and sunflower seeds having the highest amount. You can also get magnesium from herbs and spices such as parsley, coriander, chives, cumin seed, mustard seeds, fennel, and basil.

Magnesium Supplements
While each form of magnesium serves its own purpose, after much research, the two most superior forms of magnesium are magnesium citrate and magnesium glycinate, and each for their own reason.

• Magnesium citrate is one of the forms with the highest bioavailability, at 90%, which means that it is easily assimilated by the digestive system and used for maximum health benefits. In addition to offering heart health benefits and aiding in optimal nerve and muscle function, magnesium citrate is commonly used to help induce a bowel movement, encourage bowel regularity and has been studied for its ability to reduce the chances of developing kidney stones. Magnesium citrate is available in tablet form, however, is also offered in a liquid form and is great for children, too.

• Magnesium glycinate offers the same heart, nerve and muscle health benefits of magnesium citrate, however, for those who are sensitive to magnesium citrate and its bowel regularity properties, magnesium glycinate is a better solution.

• Transdermal magnesium is a topical magnesium gel that is used externally, versus being ingested orally. Rubbed directly on the affected area, transdermal magnesium can offer almost immediate relief for many symptoms, such as dry skin, muscle aches and cramps, migraine headaches, tension and stress.

Don’t wait – work on increasing your magnesium levels today so you can have a healthy heart.

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Source
Dr. Carolyn Dean, The Magnesium Miracle

Research
1. Circulating and Dietary Magnesium and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies

2. Myocardial Tissue Concentrations of Magnesium and Potassium in Men Dying Suddenly from Ischemic Heart Disease

3. Serum Magnesium is Inversely Associated with Coronary Artery Calcification in the Genetics of Atherosclerotic Disease (GEA) Study

4. Dietary Magnesium Intake is Inversely Associated with Serum C-reactive Protein Levels: Meta-Analysis and Systematic Review

5. Nutritional Epidemiological Study on Mineral Intake and Mortality from Cardiovascular Disease

6. Uric Acid-Induced C-reactive Protein Expression: Implication on Cell Proliferation and Nitric Oxide Production of Human Vascular Cells

Antioxidants | Free Full-Text | Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Chronic Mg deficiency contributes to the development and progression of HF, hypertension, atherosclerotic vascular disease, and metabolic diseases, while acute Mg deficiency has been shown to be associated with cardiac arrhythmia and neuromuscular hyper-excitability (such as pre-eclampsia and epilepsy) [190]. Recently, our group found that Mg deficiency independently induced systolic and diastolic dysfunction in mice with low Mg diet [82]. The underlined mechanisms include Mg deficiency-induced mitochondrial dysfunction, oxidative stress, oxidation of cardiac myosin binding protein C, dysregulation of Ca handling proteins such as the sarcoplasmic reticulum (SR) Ca-ATPase (SERCA) and the SR Ca release channel (i.e., the ryanodine receptor 2 (RyR2)), and suppression of Ca transient. Mg repletion reversed all the detrimental changes and restored heart function.

3.1. Mg Supplementation Improves HF

In HF patients, hypomagnesemia is frequently observed (with a reported 7%–38% range), together with other electrolyte abnormalities such as hypocalcemia [5,9]. Maintaining a normal Mg level with Mg supplementation plays a protective role on HF survival and on all-cause mortality [191]. Gottlieb et al. reported that HF patients with low Mg levels have a two-year survival rate of 42% vs. 61% for patients with normal Mg levels [39]. Mg deficiency-induced oxidative stress and inflammation contribute to the development and progression of HF [5,81,103,142], while Mg supplementation suppresses oxidative stress and inflammation and plays protective roles in HF [1,82,152].Benefits of Mg supplementation have been reported in many studies on treating HF patients with improvements in arrhythmias, diastolic and systolic function, inflammation, and myocardial infarction rate. For example, intravenous (IV) Mg sulfate (MgSO₄) treatment reduced left ventricular failure by 25% compared with saline placebo in the 2nd Leicester Intravenous Mg Intervention (LIMIT-2) trial [192,193]. A follow-up study of LIMIT-2 showed that Mg treatment significantly decreased the mortality rate from ischemic heart disease by 21% and all-cause mortality rate by 16% [193]. New York Heart Association (NYHA) class II-III HF patients with MgSO₄ infusion (40 mmol over 24 h) showed significantly reduced QT variability, and the change in QT variability was correlated inversely with patient serum Mg levels [194]. Oral Mg citrate (300 mg/day for five weeks) appears to decrease heart rate variability in HF patients, accompanied by an increased serum Mg level [57]. Oral Mg chloride (MgCl₂) treatment (380 mg/day for six weeks) [195] or IV MgSO₄ infusion (one dose, 0.1 mmol over 1 h or 8 g in 250 mL of 5% glucose over 12 h) [10,196] on patients with congestive HF significantly reduced the frequency of ventricular arrhythmias in HF patients and increased serum Mg levels. This indicates an acute effect of IV infusion on improving the symptoms of patients with congestive HF, while oral Mg administration may need longer treatment. One of the longest Mg treatments reported is oral Mg orotate for one year in patients with severe HF, showing significantly higher survival rate and improved clinical symptoms when compared with placebo [197]. In animal studies, our group has reported that MgSO₄ supplementation in drinking water improves diabetes-associated diastolic dysfunction in six weeks [1], and that Mg repletion reverses low-Mg diet induced HFpEF and HFrEF [82].

3.2. Mg Supplementation Shows Protective Effects against Arrhythmias

Mg has been used to treat different types of arrhythmias for decades, such as AF [43,44,45,198,199], TdP [41,42,200], and VA [46,47,199] (for reviews [6,201,202,203,204]). Mg is also frequently used in patients undergoing cardiac and pulmonary surgery when lethal arrhythmias often occur [44,199,204,205,206]. For example, a meta-analysis of randomized controlled trials on 2069 patients demonstrates that prophylactic Mg administration (IV MgSO₄ or MgCl₂) reduces the risk of supraventricular tachycardia and VA after cardiac surgery [205].Long-term mild and moderate hypomagnesemia is associated with AF [45]. A pilot trial supports oral Mg oxide supplementation for AF prevention [47]. IV MgSO₄ decreased the heart rate and converted to sinus rhythm patients with rapid AF [207]. Higher incidence of postoperative AF is observed in patients with lower plasma Mg levels [208]. IV Mg prevents AF after cardiac and thoracic surgery [199,204,205,209] and non-cardiac thoracic surgery [198]. IV Mg also helps control the ventricular rate in patients with AF as an adjunct to digoxin [203].TdP is most commonly caused by medications such as QT prolonging drugs [42]. Other causes for TdP include congenital long QT syndrome, electrolyte imbalance (hypomagnesemia and/or hypokalemia), bradycardia, hypothyroidism, and cardiac diseases [210]. IV Mg has been effective in treating TdP patients and is recommended as the initial therapy of choice to treat TdP, regardless of serum Mg levels [41,201,210,211]. In a study of six patients with TdP but normal Mg levels [41], IV MgSO₄ infusion (50 mg/min for 2 h) eliminated the arrhythmia within 20–30 min in all cases. A single bolus of IV MgSO₄ (2 g) has been shown to abolish TdP within 1–5 min in nine of 12 TdP patients [200]. In studies of canine TdP models, Mg rapidly prevents triggered ventricular tachycardia (VT) and eliminates TdP, probably by inhibiting early afterdepolarizations, a cellular arrhythmic mechanism [212,213]. Mg has been shown to alleviate other VAs in many studies [46,47]. Oral MgCl₂ intake decreased the occurrence of ventricular premature complexes, couplets and non-sustained VT in HF patients [195]. Oral Mg intake together with potassium exhibits antiarrhythmic effects on patients with frequent VA [46]. IV MgSO₄ administration reduced the numbers and lasting time of ventricular ectopic beats, couplets, and episodes of nonsustained VT [10,196]. A meta-analysis on 22 studies with over 6000 patients shows that the rates of VA (VT and ventricular fibrillation (VF)) and the incidence of supraventricular tachycardia are significantly lower in patients receiving IV MgSO₄ (11.9% and 10.4%, respectively) than placebo (24.2% and 23.9%, respectively) [91]. Intraoperative Mg treatment is associated with reduced occurrence of postoperative arrhythmias including VT, junctional ectopic tachycardia, and atrioventricular block [199].Mg shows protective effects on arrhythmias in MI. Low serum Mg is associated with increased risk and mortality of acute MI [191,214], and Mg deficiency, in turn, aggravates MI by inducing mitochondrial dysfunction and increasing oxidative stress-induced ischemic injury [96,110,215,216]. In Mg-treated patients, there is ~20% reduction in infarct size [217], ~24%–50% decreased mortality [20,48,192,214,218,219], decreased rates of arrhythmias after infarction [48,217,218,219,220], increased ejection fraction [221], and improved myocardial contractile function [193]. For example, in a meta-analysis with eight clinical trials, IV Mg treatment of 930 acute MI patients showed a 49% reduction in VT/VF, a 58% reduction of incidence of cardiac arrest, and a 54% reduction in mortality [48]. The mechanisms underlying the protective effects of Mg have been studied in animal MI models. Mg reduces Ca overload [49,53,216,222,223], improves cellular ATP production [49], reduces myocardial oxygen consumption [49,53], attenuates catecholamine-induced elevated oxygen demand and myocardial necrosis [216,223], and protects the post-ischemic myocardium from oxidative damage [53,224]. Mg has been proposed as an adjunct therapy option in selected cases of high-risk acute MI patients, such as elderly patients, those with left ventricular dysfunction and chronic HF, and patients not suitable for reperfusion therapy [12].The detrimental effects of Mg deficiency in arrhythmias and the protective roles of Mg supplementation have been thought traditionally to arise from Mg regulation of multiple cardiac ion channels, transporters and ionic exchangers that are responsible for the cardiac action potential, including the cardiac sodium channel [225], L-type Ca channel [58,226,227,228], T-type Ca channel [229], Na/Ca exchanger (NCX) [230,231], and K channels [232,233,234,235,236,237], such as the human ether-à-go-go-related K channel, the slowly inactivating K channel, and inward-rectifier K channels (for reviews [6,56,91,238]). Several mechanisms have been proposed for how Mg plays its roles, such as acting as a channel pore blocker, binding directly on channels, altering membrane surface potential, modulating ATP-consuming kinases and enzymes, and mediating allosteric effects on channels (see reviews [6,56,201,238]). For the cardiac sodium channel, Mg deficiency leads to a downregulation of channel function [225], which can lead to increased risks of arrhythmias by virtue of decreased conduction velocity. Mg has been proposed as a Ca antagonist for Ca channels including the L-type Ca channel, the T-type Ca channel, the NCX, and the SR RyR2. Mg_i has at least two effects on L type Ca currents: inhibition of channel open probability and on channel activity under protein kinase A phosphorylation [58,226,227,228]. Under low [Mg]_i, the NCX current is significantly increased, compared to under physiological concentration [230,231], which leads increased incidence of triggered arrhythmia [231]. Physiological concentrations of [Mg]_i mainly inhibit Ca-induced Ca release from RyR2 [239] by competing with Ca [240,241]. Under Mg deficiency, increased Ca leak from RyR2 disturbs Ca homeostasis and increases the occurrence of early and delayed afterdepolarizations. Mg_i at physiological concentrations mainly plays an inhibitory role on cardiac K channels by interfering with the passage of K ions and reducing the channel open probability [242]. Under Mg deficiency, K currents are increased [232,233,234,235,236,237], which can lead to arrhythmias [243]. Under Mg deficiency, the comprehensive effects of Mg on multiple cardiac ion channels, transporters, and ion exchangers lead to prolongation of the action potential duration, increasing the risk of triggered electrical activity, while Mg supplementation reverses these effects and alleviates arrhythmias. The protective effects of Mg supplementation may also result from the suppression of Mg on oxidative stress and inflammation, which are common in patients with CVD such as HF [244,245] and AF [246,247,248,249,250]. Oxidative stress can induce fibrosis and electrical remodeling [246,247,248,251]. Our group has reported that Mg deficiency induces oxidative stress [1,82], which promotes arrhythmias [252] and downregulations on multiple cardiac ion channels and transporters including cardiac sodium channel [251,253,254,255], Ca channels [255,256,257,258], NCX [259], RyR2 [260], and K channels [255,256,261,262,263]. Mg supplementation can inhibit ROS overproduction [1,82] and reverse oxidative stress-induced channel changes. Mg deficiency has also shown to activate PKC [145], which can downregulate the cardiac sodium channel [251,253]. Inflammation that can be induced by Mg deficiency [81] is also associated with increased arrhythmic risks [264,265] and the suppression of Mg supplementation on inflammation [146,161] should have protective effects.

3.3. Mg Treatment of Other Cardiovascular Diseases

Mg regulation of insulin signaling speaks to its importance in metabolic diseases such as diabetes and obesity. Mg deficiency is often reported in DM [1,11,23,24,26,266] and obesity [105,267,268], both of which are high risk factors of developing CVD. Strong associations are reported between metabolic diseases and hypomagnesemia, inflammation, and oxidative stress [152]. Type 1 DM patients show Mg deficiency, and Mg hydroxide (Mg(OH)₂, 500 mg/day for 21 weeks) improves insulin resistance [23] in part because of Mg upregulation of Akt2 and insulin receptor substrate 1 [183]. A meta-analysis study of randomized, double-blind controlled trials of 370 patients with type 2 DM shows that oral Mg supplementation at a median dose of 360 mg/day for a median duration of 12 weeks (4–16 weeks) is effective in reducing fasting plasma glucose levels and increasing high-density lipoprotein (HDL) cholesterol levels [266]. Long-term Mg supplementation significantly improves homeostatic model assessment of insulin resistance (HOMA-IR) index and fasting glucose in both diabetic and non-diabetic patients [269]. For example, oral MgCl₂ (26 mmol/day for three months) shows significant improvement of insulin resistance with reduced HOMA-IR index, compared with placebo [97]. Oral MgCl₂ supplementation of pre-diabetic patients with hypomagnesemia improves glycemic control with lower fasting and post-load glucose, and higher HDL cholesterol and serum Mg after four months of treatment [270]. A possible mechanism of Mg regulation of insulin signaling has been proposed in Figure 4.Mg supplementation has shown important therapeutic effects in hypertension [15,16,271] and stroke [17,18]. Mg participates in the metabolism of l-arginine-NO system, essential fatty acids and eicosanoids. With Mg deficiency, the beneficial products such NO and resolvins are suppressed, while pro-inflammatory cytokines are elevated [103]. This can result in inflammation and vasoconstriction, cause high blood pressure and platelet aggregation [272], and induce hypertriglyceridemia and pro-atherogenic changes in lipoprotein metabolism [273,274], leading to the development of atherosclerosis and stroke. Mg supplementation has shown efficacy to treat vascular disease. For instance, oral Mg pidolate (600 mg/daily for 12 weeks) significantly reduced ambulatory blood pressure in patients with mild hypertension, accompanied by increased serum and intracellular Mg levels [271]. Dickinson et al. reviewed 12 randomized controlled trials and reported that diastolic but not systolic blood pressure is significantly decreased by Mg supplementation [15]. A recent meta-analysis study of 22 trials shows that Mg supplementation (120–973 mg/day) slightly but significantly decreases both systolic and diastolic blood pressure in a dose-dependent manner [7]. Mg can inhibit tissue transglutaminase and lysyl oxidase, both of which are associated with hypertension and atherosclerosis [275]. Mg can be used to reduce thrombotic complications. The Mg transporter TRPM7 has been found to be a key modulator of phospholipase C and the platelet Ca transient. High serum Mg inhibits TRPM7 activity. Blockade of TRPM7 kinase activity causes a significant defect in platelet aggregation and exhibits protective effects from ischemic stroke [276]. Mg inhibition of mitochondrial ROS production plays a protective role in carotid artery stenosis [141].Mg deficiency has been reported to contribute to other vascular disorders such as pre-eclampsia and eclampsia [277,278,279,280,281]. IV MgSO₄ became a standard treatment for pre-eclampsia and eclampsia seven decades ago [81,277,278,279] and the pharmacokinetic properties have been studied [282,283]. MgSO₄ decreases the risk of eclampsia to half and reduces the risk of maternal death [280]. Mg supplementation helps decrease oxidative stress, suppress inflammation, reduce clotting factors [284], and increase the expression of calcitonin gene-related peptides and substance P that have vasodilatory effects and improve pre-eclampsia in women [85,285,286].

Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study | BMC Medicine

Research shows magnesium improves a form of heart failure previously without treatment — ScienceDaily

Research out of University Minnesota Medical School and published in the Journal of Clinical Investigation Insight uncovers what causes diastolic heart failure and how it can be treated.

In the article, “Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function,” author Samuel Dudley, MD, PhD, Academic Chief of Cardiology at the University of Minnesota Medical School and his fellow researchers found that magnesium can be used to treat diastolic heart failure.

“We’ve found that cardiac mitochondrial oxidative stress can cause diastolic dysfunction. Since magnesium is an essential element for mitochondrial function, we decided to try the supplement as a treatment,” explained Dudley. “It eliminated the poor heart relaxation that causes diastolic heart failure.”

Obesity and diabetes are known risk factors for cardiovascular disease. Researchers discovered the magnesium supplement also improved the mitochondrial function and blood glucose in the subjects.

Patients with diastolic heart failure have a high morbidity, mortality, and healthcare costs. Patients with this condition have similar annual mortality to patients with systolic heart failure, and up until now there was no known specific treatments for this type of heart failure.

“This is an exciting step forward in the cardiovascular field,” said Dudley, “Right now there are no specific treatments for patients with diastolic heart failure, but now we have a theory of why diastolic heart failure occurs and what we can do to get rid of it.”

The next step is human trials. Dudley says this work could also open doors for answers for a related condition, atrial fibrillation.

Story Source:

Materials provided by University of Minnesota Medical School. Note: Content may be edited for style and length.

90,000 Benefits of magnesium for the heart in case of rhythm disturbances (arrhythmias)

1. Main
2. Heart

How important is magnesium for the heart?

Everyone knows how important the heart is – it beats, a person lives, it stops and a person dies. But few people know that sufficient levels of magnesium in the body are critically needed for the normal functioning of the cardiovascular system. We decided to tell you in detail about the participation of magnesium in this complex system.

How the heart works

The heart is the most important muscle in the body, which requires a lot of energy. That is why it contains more magnesium than other organs. Scientists have proven that magnesium is part of the structure of a huge number of enzymes and in their composition participates in the production of energy, so necessary for the muscle fibers of the heart. It is responsible for energy metabolism in the heart muscle and improves the supply of oxygen to cells. That is why magnesium is so important for the heart.

What is our heartbeat?

This is muscle contraction and relaxation. This process involves two minerals – calcium and magnesium. And, if calcium is responsible for the contraction of muscle tissue, then magnesium is responsible for relaxation. In the vessels of the body, magnesium also acts: the walls of the vessels consist of muscle tissue, magnesium expands the lumen of the vessels by relaxing the wall, which leads to the normalization of high blood pressure. That is why a sufficient level of magnesium in the body is so important for hypertension.

Magnesium for arrhythmias or cardiac arrhythmias

The cells that make up our heart have a special name – cardiomyocytes.

Magnesium controls the functioning of these cells so that the contraction-relaxation cycle occurs normally at the cellular level, as a result, the heart rate is stabilized. If there is not enough magnesium in the body, heart rhythm disturbances may occur. Increased heart rate, abnormal heart rhythm, when excessive heart contractions occur, or vice versa, the heart skips beats.Thus, irregular heartbeat may be related to magnesium levels in the body.

Did you know?

Another important property of magnesium for the heart and blood vessels is the effect on blood clotting. The use of magnesium preparations helps to reduce the tendency to form a blood clot and thins the blood.

A very interesting fact about arrhythmia is that magnesium is involved in the energy conversion of carbohydrates – it is necessary for signal transmission from insulin receptors and for the effective breakdown of sugar.The question arises, what does the heart have to do with it? With a deficiency of magnesium, the body mass index and the percentage of fat increase, the process of absorption of sugars is disrupted, which ultimately leads to obesity, diabetes mellitus and heart problems – arterial hypertension and hypertension.

Magnesium deficiency is quite common in those taking medications for the treatment of chronic heart failure and diuretics. This must be taken into account in the individual treatment and rehabilitation program.For people taking diuretics, regular intake of heart vitamins with magnesium is extremely important because diuretics increase the excretion of this mineral from the body.

Stress, heart, magnesium – a vicious circle

The high value of magnesium for the heart is associated with the ability of this mineral to reduce the severity of stress. Stress and magnesium deficiency are interrelated processes that exacerbate each other. And stress, unfortunately, is a risk factor for the development of cardiovascular disease.Magnesium deficiency contributes to the development of pathological stress anxiety. Magnesium affects the functions of the central nervous system, it can reduce the body’s susceptibility to stress and improve the emotional background.

Nature invented everything for us

According to numerous studies, the optimal content of magnesium in the body is a factor in the health of the cardiovascular system.

What other natural properties does magnesium have?

It has a protective effect – it has a beneficial effect in case of heart rhythm disturbances, coronary heart disease, including myocardial infarction.At the same time, magnesium has a vasodilating effect and helps to lower blood pressure. Researchers have long identified a link between the magnesium content of drinking water and the incidence of cardiovascular disease and atherosclerosis.

According to the European Epidemiological Study of Cardiovascular Diseases, low blood magnesium levels are considered an additional risk factor for stroke and heart attack. Low magnesium levels during arrhythmias negatively affect the work of the heart muscle and blood vessels.Symptoms of its deficiency are manifold: disturbance of the heart rhythm, pain in the heart due to vasospasm, increased blood pressure; increasing cholesterol, accelerating the development of atherosclerosis; a tendency to form blood clots.

Magnesium sufficiency for the cardiovascular system is very important and important, especially when there is already a violation of the rhythm or work of the heart. That is why heart vitamins with magnesium can be beneficial. As one of the possible options for taking magnesium, you can consider the addition of Magnesol B ₂ granules.

Things to Remember

• Magnesium is no less important for the heart than potassium or calcium.
• A sufficient level of magnesium in the body is important, and even more so with arrhythmias – a violation of the heart rhythm may be associated with an insufficient content of magnesium in the body.
• The magnesium content in the body is directly related to stress, and stress has a negative effect on the cardiovascular system.
• Always read the instructions for use before taking heart vitamins with magnesium.

Magnesol B ₂ granules contains magnesium and vitamin B ₂ . Each dose (1 sachet) of Magnesol B ₂ granules contains 300 mg of magnesium, in the form of citrate, which is easily absorbed by the body and is well tolerated. Magnesium citrate is well absorbed from the gastrointestinal tract and improves the penetration of magnesium into cells.

90,000 Useful Information – Articles everyone should read.

There are substances without which the normal functioning of the heart and the entire cardiovascular system is practically impossible.Indeed, the heart of both healthy and sick people needs support. And it necessarily includes the intake of certain vitamins and minerals.

Vitamins for the heart with magnesium and potassium are an essential component of the prevention of heart disease. Antioxidant vitamins protect blood vessels and heart cells from free radicals, B vitamins are necessary for blood formation and oxygen supply to the heart, and magnesium is required for contraction of all muscles, including the myocardium.

Preparations with potassium and magnesium are so important also because they help the body withstand stress and work normally even with increased emotional stress. After all, B vitamins strengthen the nervous system, and magnesium is often called “fuel” for stress, because it reduces the excitability of the nervous system. However, it is worth considering the fact that vitamins for the heart with magnesium should also contain potassium, since potassium is also involved in the contraction of the heart muscle. Potassium and magnesium should be taken together as they regulate the absorption of each other.

It is desirable that the vitamins for the heart with potassium magnesium also be fortified with coenzyme q10. This is another substance, without which the work of the heart is impossible. Coenzyme Q10, magnesium and potassium are part of the drug, which is called Kudesan with potassium and magnesium.

Preparation with potassium and magnesium Kudesan

Qudesan with potassium and magnesium supports the normal functioning of the heart – after all, coenzyme Q10 supplies it with energy and protects it from the effects of free radicals, and potassium and magnesium are necessary for the full contraction of the heart muscle and the conduction of nerve impulses.

On the other hand, due to the fact that coenzyme Q10 slows down the aging process and prevents the development of atherosclerosis, and potassium and magnesium nourish and strengthen the heart muscle, maintain vascular elasticity, taking Kudesan with potassium and magnesium will help prevent the development of diseases of the cardiovascular system and provide uninterrupted work of the heart for many years.

Take care of yourself! Take regular potassium and magnesium supplements and coenzyme Q10 supplements. This simple action will help your heart stay healthy for years to come.

90,000 The doctor spoke about the benefits of magnesium for the heart

– More often than others, the deficiency of magnesium and calcium is experienced by those who have already entered the second half of their life, – believes Doctor of Medical Sciences, Professor Valery YAKOVLEV . – Today, up to 80% of Russians experience a lack of these microelements, but not everyone knows how to quickly replenish them. Moreover, not only the person himself may not be aware of the deficiency, for example, of magnesium in the body, but doctors do not immediately recognize the cause of the ailment.Symptoms are similar to a condition when immunity is reduced. Although the trace element magnesium may be to blame, which takes part in almost all biochemical processes of the body, plays a major role in carbohydrate, protein and lipid metabolism, affects immunity, and takes part in the normalization of blood pressure …

Add energy and protect against radiation

– If your well and long working organism suddenly began to malfunction, then one of the reasons may be a magnesium deficiency, – our expert Valery Yakovlev believes.- Traditionally it is believed that it is good for the heart, memory and the nervous system. And this is really so: this microelement maintains the nervous system and heart muscles in a normal state, a uniform heart rate, normalizes blood pressure, and makes a person more energetic. But not only. This mineral is called the “core of life” due to the fact that it is simply irreplaceable for humans: it participates in dozens of chemical reactions in our body, is necessary at all stages of protein synthesis, and also makes our bones stronger, stimulates bile secretion, and regulates blood sugar levels…

And one more of the most important properties of magnesium – it protects against radiation. This was proved by researchers at the Japan National University – they included it in the list of means to combat the consequences of the harmful effects of radiation on humans.

REFERENCE “MK”

Scientists have calculated that there are about 70 g of magnesium in our body. Most of it is found in the bones (magnesium helps the growth of cartilage and bone tissue and the absorption of calcium and vitamins C, E and group B).Another part of magnesium is found in the cells of the brain, heart, in the liquid. And a small part is in tissues and muscles. The daily requirement for magnesium for adults is 310-420 mg; for women who are pregnant and during breastfeeding, the need is 20–30% higher (up to 340–355 mg). For athletes – up to 450 mg. In terms of volume in the human body, magnesium ranks fourth after sodium, potassium and calcium.

According to the professor, it is as easy as shelling pears to replenish the missing trace element – with the help of nutrition.You just need to know which foods contain the most magnesium.

Most of all magnesium contains: green vegetables and fruits, lettuce, parsley, dill, celery (the green color of chlorophyll molecules indicates the presence of magnesium in them). Magnesium is also found in legumes, nuts and whole grains, and sprouted wheat grains. Some varieties of fish are rich in it: cod, carp, halibut, as well as shrimp and seaweed.

Fights stress and insomnia

– A person experiences stress in a state of emotional or physical overload, the expert states.“Our body reacts to everything: to excessive workloads, to family troubles, to conflicts,” says our expert Valery Yakovlev. – The life of a modern person, alas, is associated not only with positive emotions, it often tests us for strength. Not everyone and not always manage to cope with the rolling problems. Someone, hoping to get away from stress, resorts to alcohol, other doping. But this only aggravates the condition.

At all times, there has been a link between stress and illness, especially heart disease, and sudden death.And today the number of heart attacks, sudden deaths increases sharply during natural disasters (floods, earthquakes, etc.). Back in the first half of the 1st century. AD the ancient Roman scientist and physician Cornelius Celsus pointed out the connection between the mind and the heart, noting that “fear and anger, as well as other states of mind, can often cause an agitated pulse.”

Much later, centuries later, other doctors and scientists stated: heart disease “occurs because of the passions of the mind” (they included “anger, fear, jealousy, horror, despair, greed, stupidity and ambition”).

Modern researchers have confirmed that stress negatively affects all types of body activities, metabolism, and magnesium plays a positive role.

There is another problem directly related to stress – sleep deprivation. Lack of sleep prevents a person from fully recovering from daily activities. As a result, new stress is usually more severe than the previous one. It turns out a vicious circle. Insomnia, like stress, is often caused by a deficiency in the body of magnesium, a mineral that plays a major role in the state of the nervous system.Without magnesium, our nerve cells become easily excitable, they cannot transmit nerve impulses. The result is increased sensitivity and susceptibility to external stimuli. Resorting to alcohol, other ways to relax, sleeping pills will only aggravate the situation. Hypersensitivity to external stimuli is most likely a symptom of magnesium deficiency in the body. The expert is convinced that if the food contains the nutrients the body needs, recovery from stress will go much faster.

Reduce stress, promote good sleep: warm milk with saffron, turmeric or honey, chamomile tea, oatmeal, bananas, almonds.

Calms hypertension, helps the heart

High blood pressure, as you know, is also very often associated with stress and nervousness, the expert adds. And studies show that it too can be reduced by using foods that contain magnesium. Under the influence of this microelement, the muscles relax, the vessels expand and the pressure returns to normal.But today’s food is far from complete. And if the body chronically lacks the nutrients it needs, this entails a malfunction in the work of internal organs, which manifests itself in stressful situations.

Today’s food is very different from the food of even our dim-witted great-grandfathers. Now the soil is different, it is depleted in natural ingredients, stuffed with chemicals, and vegetables grown on it are subjected to industrial and thermal processing. As a result, they lose most of the beneficial properties, in particular, magnesium.

But few people know about it. Ask any resident of our country: do they know what magnesium is, is there enough of it in their menu? Ten out of ten will answer no. Although magnesium in our body is involved in dozens of biochemical processes. The effect of assimilation of other essential microelements in the body (calcium, potassium, sodium) depends on magnesium. If magnesium is lacking, calcium, potassium and sodium will be poorly soluble in the blood, and most of them will settle in soft tissues in the form of crystals.And bones of these minerals are often lacking.

For hypertension useful: low-fat cottage cheese and milk (contain not only magnesium, but also calcium, potassium), green tea, bell peppers, oatmeal, pumpkin seeds.

– The human heart is the main muscle in our body, it continuously pumps blood through the vessels, – explains expert Yakovlev. – Heart disease plagues many people, especially over the age of forty. Today, medicine has a huge amount of drugs to treat heart ailments, but people continue to get sick and die from the pathologies of the main motor of life.Scientists in the United States have conducted several studies in this area and have identified the factors that create the risk of heart disease. Many factors are caused by magnesium deficiency. According to these studies, most heart disease today is a direct result of inadequate intake of foods containing this trace mineral.

And other muscles (intestines, eyes, etc.) – also work better under the influence of magnesium – they contract, contract and unclench better. Experts explain it this way: magnesium is able to relax muscles, and this helps the normal circulation of all fluids in the body, including blood.And if the muscles are compressed, it impedes the movement of fluids, which leads to increased blood pressure, spasms, headaches, etc.

There is also one of the most well-known and necessary microelements for humans – calcium, the expert adds.

REFERENCE “MK”

The daily calcium requirement of a healthy adult is from 700 to 1500 mg. It increases during pregnancy and breastfeeding. Sesame is considered the champion in calcium content, but only fresh.Dairy and fermented milk products (its main source) are rich in calcium, as well as broccoli and cauliflower, spinach, asparagus. Calcium is also found in egg yolks, beans, lentils, nuts, and figs. A good source of dietary calcium is considered to be soft fish bones (salmon, sardines), any seafood.

Calcium and magnesium are two minerals that must work together. Calcium is responsible for tightening muscles and stimulating nerves in the body, while magnesium is responsible for relaxing them. For all muscles to work in harmony, calcium and magnesium must be in the body in strict proportion.But more often it happens that there is more calcium in the body and less magnesium. As a result, the muscles remain chronically tight and tense. Tight muscles make it difficult for fluids and blood to circulate, leading to high blood pressure, headaches, and more. A sufficient amount of magnesium in the body “releases” tight muscles, and the circulation of fluids is gradually restored.

Good for the heart: products containing magnesium – fresh cabbage, apples, lemons, carrots, bran, nuts, milk, buckwheat, oatmeal; as well as foods containing calcium: parsley, spinach, dill, celery, green salads, asparagus, young beans.

… So, magnesium is a key component in the formation of energy potential in every cell of our entire body, our expert Valery Yakovlev is convinced. Its amount directly affects a person’s mobility, physical activity, mood, and metabolism in general. After all, vigorous health depends on how well the metabolism proceeds in our body.

And magnesium also regulates the work of potassium in the body. Potassium, in turn, maintains water balance and also participates in energy production.And it regulates the adrenal glands, which play an important role in adapting the body to stress. During an emergency, they produce and release the hormone adrenaline into the bloodstream, which helps a person to activate for a while: to do everything faster, to be more collected, more mobile.

Scientists have proven: there are factors that provoke increased magnesium consumption. Definitely – this is smoking, alcohol, drugs; junk food and drinks containing sugar; diuretic medicines; chronic diseases: decreased thyroid function, diabetes, pregnancy, breastfeeding, etc.And the absorption of magnesium is hampered by excess fat in foods.

Potassium magnesium WTF – news Planet of Health

Active substance:
Potassium asparaginate; magnesium asparaginate;

Content of active substances in 4 tablets (daily intake):
potassium-376 mg; magnesium-60 mg.

Recommended as a biologically active food supplement – an additional source of potassium and magnesium.

Advantages of the Potassium Magnesium product.

The heart simultaneously receives two essential substances for its work – potassium and magnesium .
The content of both of these minerals is normalized, since potassium deficiency cannot be eliminated if there is not enough magnesium in the body.
Potassium and magnesium easily penetrate into the extracellular space, as they are contained in the form of asparaginate, which is their effective carrier.

Z The value of potassium for the cardiovascular system.
Potassium regulates myocardial contraction and ensures the passage of nerve impulses. Also potassium provides blood pressure stability.
With a lack of potassium, weakness, cramps, muscle pain and other disturbances in the work of the heart (up to arrhythmias) occur.
An increased need for potassium occurs in diseases of the cardiovascular system, emotional stress, increased physical exertion, the use of thiazide diuretics, frequent use of coffee and coffee beverages; if the diet contains foods high in: sodium (salt, flavor enhancers, etc.)etc.), sugar; with alcohol abuse.
Supplementing with potassium helps prevent heart problems.

The role of magnesium in the work of the heart.
Magnesium is necessary to maintain a stable heart rate, since it ensures the functioning of the cardiac conduction system.
With a lack of magnesium, cramps and muscle spasms occur, which is especially dangerous for the myocardium.
With heart failure, stress, depression, physical exertion, migraines, malnutrition, the content of magnesium in the body decreases, so additional intake is required.

Additional benefits of asparaginate.
Aspartate is an organic salt of aspartic acid. Entering the cells, asparaginate is included in the metabolism, enhancing the production of energy in the form of ATP. This is especially important for the heart, which belongs to the most “energy-intensive” organs and whose full-fledged work depends on the supply of energy.

BAA. NOT A DRUG.

Macronutrients – Federal State Budgetary Institution “NMITs TPM” of the Ministry of Health of Russia

– Sodium (daily requirement 4–5 g) plays an important role in the transmission of nervous excitement, in muscle contraction, in the regulation of fluid balance in the body, it is found in ordinary table salt. The body has enough sodium, which is found in natural food.

In fact, most people consume 2-3 times more salt, so drink more water to lower the concentration.With a lack of potassium, sodium is retained, retaining the water you drink. If a person suffers from hypertension, then sodium and water accumulate in the walls of blood vessels and tissues, which leads to an increase in blood pressure and an increase in the load on the heart.

– Potassium (daily requirement 3 g) The main manifestations of potassium deficiency in the body are muscle weakness, fatigue, and rapid heartbeat. A lack of potassium leads to impaired cardiac activity and nerve conduction.Potassium helps to remove excess fluid from the body, normalizes blood pressure and improves the activity of the heart muscle.

-Magnesium (daily requirement 0.3-0.5 g) Magnesium has a vasodilating and diuretic effect. A lack of magnesium salts in food disrupts the normal excitability and conductivity of the nervous system, muscle contraction.

-Calcium (daily requirement 0.8-1.2 g) Calcium plays an important role in the work of the heart, regulates the excitability of nerve and muscle cells, participates in blood coagulation, is part of bones and teeth.When the cells of the body do not get enough calcium from food, they begin to take it from the bone tissue.

– Phosphorus (daily requirement 1–1.5 g) Phosphorus salts are involved in the formation of bones. They are accumulators of energy, which is used during muscle contraction, in biochemical processes

You can make an appointment with the specialists of our center by phone: +7 (495) 790-71-72, +7 (495) 510-49-10

Useful properties of magnesium

Published: Updated: 13.08.2021 Views: 640 90 009

Magnesium is one of the essential minerals that humans need in large quantities. Magnesium interacts with many enzymes in the regulation of body temperature and protein synthesis, as well as in the transmission of nerve impulses between cells – the most important process in the human body.

Let’s see what is such an important role of magnesium and why it is necessary for the human body.It is amazing, but true: without magnesium, not a single system of our body can function properly!

First of all, this microelement is involved in the most important metabolic processes – energy, protein, carbohydrate and fat. Magnesium is very important for the normal functioning of cells, muscles, the entire nervous system and organs.

Magnesium plays an essential role in a woman’s health: a sufficient amount of it noticeably alleviates PMS syndromes, it also promotes ovulation, conception, favorable pregnancy and childbirth (it participates in the transfer of genetic information and has a beneficial effect on muscle tone).

• Magnesium “works” for our beauty from the inside: participating in metabolic processes, it contributes to the fact that the skin and hair are always in excellent condition, even in winter. By positively affecting the functioning of the digestive system, it controls our weight.
• Accumulating solar energy, magnesium saturates our cells with it, being responsible for the energy potential of the body. Our vitality and vitality directly depend on a sufficient amount of magnesium in the body!
• By regulating the transmission of nerve impulses, it deprives the cell of the so-called “over-excitability”.As a result, the person becomes balanced, calmly and adequately reacts to the events taking place.
• By regulating the tone of blood vessels, magnesium normalizes blood pressure.
• Magnesium and calcium control the work of muscles (and, in particular, of the heart): calcium is responsible for their contraction, while magnesium relaxes them in time, relieving overstrain in the form of cramps. With a sufficient amount of magnesium, the heart will never fail.
• Calcium is absorbed by the body through magnesium.Therefore, for any bone problem, calcium and magnesium are always taken together.
• Magnesium plays a role in the immune processes, participating in the formation of the immune response, resistance to infections, allergic reactions.

These are just the basics to talk about. The main thing to remember is that everyone, especially women, needs to monitor the balance of magnesium in the body. And if you notice symptoms of a lack of magnesium (low tone, irritability, PMS, headaches and high blood pressure, muscle dysfunction), you need to use the services of laboratory diagnostics on time, then take a course of magnesium-containing preparations, proven by time and specialists, and be calm about your health!

Source: http: // magneb6.ru /

Author:
Baktyshev Alexey Ilyich, General practitioner (family doctor), ultrasound diagnostics doctor, chief physician

Dietary supplement Kudesan Cardio Potassium and magnesium 40 tablets

Dietary supplement for food “Cardio Potassium and Magnesium tablets of the Kudesan trademark” is used as an additional source of coenzyme Q10 (ubiquinone), potassium and magnesium.

“Cardio Potassium and Magnesium tablets of the Kudesan trademark” is a source of coenzyme Q10, which reduces the risk of developing cardiovascular diseases, such as hypertension, coronary heart disease, myocardial infarction, stroke, is recommended in the complex therapy of arrhythmias, hypertension, heart failure.

The original combination of coenzyme Q10 and trace elements provides comprehensive support for the cardiovascular system. Coenzyme Q10 is a powerful antioxidant, potassium and magnesium are essential nutrients for normal heart function.

One tablet contains: coenzyme Q10 7.5 mg, magnesium asparaginate 250 mg (including magnesium 16 mg), potassium asparaginate 450 mg (including potassium 97 mg).

Coenzyme Q10, potassium and magnesium have a multifaceted effect on the activity of the heart: they support the normal functioning of the myocardium. Coenzyme Q10 supplies the heart with energy and protects against free radicals, while potassium and magnesium are essential for the normal contraction of the heart muscle and the conduction of nerve impulses. They are also involved in the prevention of cardiovascular diseases by feeding the heart muscle.Coenzyme Q10 slows down the aging process and prevents the development of atherosclerosis, potassium and magnesium strengthen the heart muscle, maintain vascular elasticity.

Content of biologically active substances in 4 tablets:

* – percentage of the recommended level of daily consumption in accordance with TR CU 022/2011 “Food products in terms of their labeling.”

** – percentage of the adequate level of consumption of food and biologically active substances according to the “Values ​​of daily consumption of food and biologically active substances for adults in the composition of specialized food products (SPP) and dietary supplements for food” changes to the Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary and epidemiological supervision (control).

*** – information on the nutritional value of the product is determined by calculation based on the average content of the biologically active substance in the product.

Recommendations for use: for adults 2 tablets 2 times a day with meals. Duration of admission is 1 month.

Contraindications: individual intolerance to the components of the product. It is recommended to consult a doctor before use.

Expiry date: 2 years.

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