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Magnesium oxide 400 mg uses: Magnesium Oxide Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


Benefits, Side Effects, Dosage, and Interactions

Much like other types of magnesium, magnesium oxide has many health benefits. When used regularly, magnesium oxide can help boost low magnesium levels, relieve constipation, manage depression, treat migraines, and more. 

Magnesium oxide is a type of magnesium mineral supplement that is mostly made of magnesium—it actually contains more magnesium than other magnesium supplements. Magnesium oxide is acquired by burning magnesium with pure oxygen, but this method is quite costly. The cheaper method is to expose oxygen to magnesium salts using underground deposits, seawater, or salt beds. With this method, the source of the magnesium salt determines the quality of the magnesium oxide that is produced.

Illustration by Brianna Gilmartin, Verywell​

Health Benefits

Magnesium oxide offers some impressive health benefits and can help to relieve the symptoms of a variety of conditions.

Regulates Magnesium Levels

Magnesium deficiency has a number of contributing factors including diet, food allergies, alcoholism, and poor kidney health. Symptoms of magnesium deficiency may include:

  • Leg cramps
  • Cardiac issues: arrythmias, palpitations, blood pressure changes, murmurs
  • Muscle and bone pain
  • Anxiety and depressed moods
  • High blood pressure
  • Insomnia
  • Fatigue

Supplementation of magnesium oxide can maintain healthy levels of magnesium throughout the body. In fact, supplementation eliminates many of the symptoms associated with deficiency.

Manages Gastrointestinal Problems

When magnesium oxide is mixed with water, it is called magnesium hydroxide—this mixture can help with naturalizing stomach acids. One study of 276 people found that a combination of simethicone (an agent used to decrease gas), activated charcoal, and magnesium oxide was more effective than a placebo for managing indigestion. Many antacids use magnesium hydrogen-based substances, but few studies have looked at the effectiveness of magnesium oxide alone.

Relieves Depression 

Magnesium oxide may help manage depressive symptoms and behaviors, as it may have positive mental health and stress reduction effects. Several studies have confirmed an association between magnesium intake and depression.

Reduces Blood Pressure and Risk of Stroke

Research from the American Journal of Clinical Nutrition finds that diets high in magnesium can reduce the risk of stroke, especially ischemic strokes. This type of stroke occurs when the artery to the brain is blocked.  The cause of most ischemic strokes is high blood pressure, and research finds that magnesium supplementation can help to lower blood pressure.

Reduces Migraines

Magnesium oxide supplementation may reduce the number and intensity of migraines. Research shows the majority of migraine sufferers are magnesium deficient. The American Migraine Foundation finds magnesium to be an ideal treatment for migraine relief and prevention.

Lowers Colorectal Cancer Risk

Some research indicates magnesium oxide supplements may reduce the risk of colorectal cancer. Research reported in the American Journal of Clinical Nutrition finds that high doses of magnesium are linked to a lowered risk of colorectal tumors. The report suggests that for every 100-milligram increase in magnesium, the risk of developing a tumor is reduced by 12%.

Possible Side Effects

Upset stomach and diarrhea are the most common side effects of magnesium oxide. Taking magnesium oxide with food can reduce stomach troubles. If side effects are persistent or if they worsen, it is best to talk to your doctor. Most people using magnesium oxide supplements do not have serious side effects.

Serious allergic reactions to magnesium oxide are rare. However, anyone who has symptoms of rash, itching, swelling, severe dizziness and/or trouble breathing should seek immediate medical attention. 

People with kidney problems should talk to their doctors before starting magnesium oxide supplements. In addition, pregnant and breastfeeding mothers should avoid magnesium oxide as risks are unknown.

It is crucial to consult with a doctor before starting or continuing supplements.

Dosage and Preparation

The recommended daily allowance (RDA) of magnesium for young adults is 400 mg per day for men and 310 mg per day for women. In adults over 30 years old, the RDA is 420 mg per day for men and 320 per day for women.

Magnesium oxide supplements should be taken by mouth with meals to reduce stomach upset. Supplements should not be crushed or chewed because doing so will increase the risk of side effects. If taken in liquid form, shake and measure the proper dose according to instructions on the supplement’s label.

If you take magnesium supplements, they should be taken regularly and at the same time daily in order to get the most benefit. Dosage should not be increased without a doctor’s approval. If you are taking a magnesium supplement, any missed doses should be taken as soon as you remember—if it is already time for the next dose, then the missed dose should be skipped. Doses should not be doubled up.

Though magnesium oxide provides a host of health benefits, too much magnesium in the blood can cause serious side effects.

Anyone who thinks they have low magnesium levels should talk to their doctor. The most common symptoms of deficiency are muscle cramping, fatigue, depression, and irritability.

What to Look For

Magnesium oxide supplements are available over-the-counter (OTC) without a prescription. Magnesium oxide is sold under several brand names including Mag-Ox 400, Uro-Mag, and Magox. Your doctor or pharmacist can advise you on which brand might be a good fit for your unique situation and overall health.

Before picking up a magnesium supplement, it is a good idea to have your magnesium levels checked by a doctor. There is no way to know if any symptoms you might be experiencing are related to a magnesium deficiency, another deficiency, or an illness. You should always disclose all health conditions and medications to avoid interactions and adverse reactions.

Other Questions

What is the best source of magnesium?

The best way to get magnesium is through diet and eating a variety of magnesium-rich foods, such as salmon and mackerel, quinoa, black beans, pumpkin seeds, and dark chocolate. Supplements are an option for maintaining magnesium levels in people whose magnesium levels remain low despite diet changes. 

How do I determine if I should take a magnesium oxide supplement?
A doctor is in the best position to determine if magnesium oxide supplements are needed for maintaining and/or increasing magnesium. Anyone who thinks their magnesium is low should talk to their doctor before starting a magnesium supplement. 

A Word From Verywell

Getting enough magnesium is important for good health. Without it, the body cannot function. Magnesium can be ingested by eating foods rich with magnesium such as salmon, quinoa, and black beans. Although your daily dose of magnesium is crucial, consuming magnesium in excessive quantities can be detrimental to your health. Be sure to consult with a doctor if you have symptoms of magnesium deficiencies or if you are considering taking a magnesium supplement.

magnesium oxide

What is the most important information I should know about magnesium oxide?

Before you take magnesium oxide, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding. In some cases, you may not be able to take magnesium oxide, or you may need a dose adjustment or special precautions.

What is magnesium oxide?

Magnesium is a naturally occurring mineral. Magnesium is important for many systems in the body especially the muscles and nerves.

Magnesium oxide is used as a supplement to maintain adequate magnesium in the body.

Magnesium oxide is also used as an antacid to treat indigestion, or as a laxative to relieve occasional constipation.

Magnesium oxide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking magnesium oxide?

You should not use magnesium oxide if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially:

  • kidney disease;
  • heart disease;
  • nausea, vomiting;
  • a blockage in your intestines;
  • low levels of calcium in your blood; or
  • a sudden change in bowel habits for 2 weeks or longer.

It is not known whether magnesium oxide will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.

It is not known whether magnesium oxide passes into breast milk or if it could affect a nursing baby. Ask a doctor before using this medicine if you are breast-feeding.

Do not give this medicine to a child without medical advice.

Magnesium oxide should not be given to a child younger than 6 years old.

How should I take magnesium oxide?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

When using this medicine as a laxative, it may be best to take your dose at bedtime.

Magnesium oxide may be taken with food if it upsets your stomach.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if symptoms get worse.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since magnesium oxide is sometimes used when needed, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, weakness, breathing problems, slow reflexes, weak pulse, extreme drowsiness, and feeling dizzy or light-headed.

What should I avoid while taking magnesium oxide?

Magnesium oxide can make it harder for your body to absorb other medicines you take by mouth. Avoid taking other medicines within 2 hours before or 2 hours after you take magnesium oxide. You may need to wait 4 hours to take your other medicines after taking magnesium oxide. Ask your doctor how to best schedule your medications.

What are the possible side effects of magnesium oxide?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using magnesium oxide and call your doctor at once if you have:

  • rectal bleeding;
  • coughing up blood or vomit that looks like coffee grounds;
  • bloody or tarry stools; or
  • no bowel movement after using magnesium oxide as a laxative.

Common side effects may include:

  • diarrhea; or
  • upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect magnesium oxide?

Ask a doctor or pharmacist if it is safe for you to take magnesium oxide if you are also using any of the following drugs:

  • an antibiotic;
  • a diuretic or “water pill”;
  • penicillamine;

  • a blood thinner –warfarin, Coumadin, Jantoven; or

  • medicine to treat osteoporosis or Paget’s disease –alendronate, ibandronate, risedronate, Fosamax, Boniva, Actonel, and others.

This list is not complete. Other drugs may interact with magnesium oxide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about magnesium oxide.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2020 Cerner Multum, Inc. Version: 4.01. Revision date: 4/28/2017.

Therapeutic Uses of Magnesium – American Family Physician

2. Alaimo K,
McDowell MA,
Briefel RR,

et al.
Dietary intake of vitamins, minerals, and fiber of person ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988–91 Adv Data.

3. Marier JR.
Magnesium content of the food supply in the modern-day world. Magnesium.

4. Thomas D.
A study on the mineral depletion of the foods available to us as a nation over the period 1940 to 1991. Nutr Health.

5. LaValle JB.
Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Altern Ther Health Med.

6. Guerrero-Romero F,
Rodríguez-Morán M.
Hypomagnesemia is linked to low serum HDL-cholesterol irrespective of serum glucose values. J Diabetes Complications.

7. Gropper SS,
Smith JL,
Groff JL.
Magnesium. Advanced Nutrition and Human Metabolism.
4th ed.Belmont, Calif: : Wadsworth Publishing; 2005

8. Food and Nutrition Board, Institute of Medicine.
Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride.
Washington, DC: National Academy Press; 1997.

9. Elin RJ.
Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol.

10. Takaya J,
Higashino H,
Kobayashi Y.
Intracellular magnesium and insulin resistance. Magnes Res.

11. Newhouse IJ,
Finstad EW.
The effects of magnesium supplementation on exercise performance. Clin J Sport Med.

12. Bohl CH,
Volpe SL.
Magnesium and exercise. Crit Rev Food Sci Nutr.

13. Rude RK,
Shils ME.
Magnesium. In:Shils ME,
Shike M,
Ross AC,
Caballero B,
Cousins RJ.
, eds. Modern Nutrition in Health and Disease.
10th ed.Philadelphia, Pa: Lippincott Williams & Wilkins; 2005:223–248.

14. Chubanov V,
Gudermann T,
Schlingmann KP.
Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch.

15. Paolisso G,
Barbagallo M.
Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens.

16. Barbagallo M,
Dominguez LJ,
Galioto A,

et al.
Role of magnesium in insulin action, diabetes and cardiometabolic syndrome X. Mol Aspects Med.

17. Suárez A,
Pulido N,
Casla A,
Casanova B,
Arrieta FJ,
Rovira A.
Impaired tyrosine-kinase activity of muscle insulin receptors from hypomagnesaemic rats. Diabetologia.

18. Yu JS,
Lee SC,
Yang SD.
Effect of Mg2+ concentrations on phosphorylation/activation of phosphorylase b kinase by cAMP/Ca(2+)-independent, autophosphorylation-dependent protein kinase. J Protein Chem.

19. Arner P,
Pollare T,
Lithell H,
Livingston JN.
Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia.

20. Witlin AG,
Sibai BM.
Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol.

21. Duley L,
Henderson-Smart D.
Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev.

22. Duley L,
Gulmezoglu AM.
Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev.

23. Belfort MA,
Anthony J,
Saade GR,
Allen JC Jr,
for the Nimodipine Study Group.
A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med.

24. Duley L,
Gülmezoglu AM,
Henderson-Smart DJ.
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev.

25. Altman D,
Carroli G,
Duley L,

et al.
Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet.

26. Banai S,
Tzivoni D.
Drug therapy for torsade de pointes. J Cardiovasc Electrophysiol.

27. Onalan O,
Crystal E,
Daoulah A,
Lau C,
Crystal A,
Lashevsky I.
Meta-analysis of magnesium therapy for the acute management of rapid atrial fibrillation. Am J Cardiol.

28. Bashir Y,
Sneddon JF,
Staunton HA,

et al.
Effect of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease. Am J Cardiol.

29. Rowe BH,
Bretzlaff JA,
Bourdon C,
Bota GW,
Camargo CA Jr.
Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev.

30. Cheuk DK,
Chau TC,
Lee SL.
A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child.

31. Fogarty A,
Lewis SA,
Scrivener SL,

et al.
Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin Exp Allergy.

32. Blitz M,
Blitz S,
Beasely R,

et al.
Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev.

33. Mauskop A,
Altura BT,
Cracco RQ,
Altura BM.
Intravenous magnesium sulfate relieves cluster headaches in patients with low serum ionized magnesium levels. Headache.

34. Mauskop A,
Altura BT,
Altura BM.
Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine. Headache.

35. Peikert A,
Wilimzig C,
Köhne-Volland R.
Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia.

36. Pfaffenrath V,
Wessely P,
Meyer C,

et al.
Magnesium in the prophylaxis of migraine–a double-blind placebo-controlled study. Cephalalgia.

37. Bigal ME,
Bordini CA,
Tepper SJ,
Speciali JG.
Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study. Cephalalgia.

38. Holtmeier W,
Holtmann G,
Caspary WF,
Weingärtner U.
On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study. J Clin Gastroenterol.

39. DeVault KR.
Treatment of intermittent reflux symptoms: one size does not fit all [editorial]. J Clin Gastroenterol.

40. Ramkumar D,
Rao SS.
Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol.

41. Andrews CN,
Bharucha AE.
Review: good evidence supports polyethylene glycol and tegaserod for constipation. ACP J Club.

42. Stendig-Lindberg G,
Tepper R,
Leichter I.
Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporsis. Magnes Res.

43. Tucker KL,
Hannan MT,
Chen H,
Cupples LA,
Wilson PW,
Kiel DP.
Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr.

44. He K,
Liu K,
Daviglus ML,

et al.
Magnesium intake and incidence of metabolic syndrome among young adults. Circulation.

45. Guerrero-Romero F,
Rodríguez-Morán M.
Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev.

46. Young GL,
Jewell D.
Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev.

47. Proctor ML,
Murphy PA.
Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev.

48. Gums JG.
Magnesium in cardiovascular and other disorders. Am J Health Syst Pharm.

49. Martindale W,
Parfitt K.
, eds Martindale: The Complete Drug Reference.
32nd ed.London: Pharmaceutical Press; 1999.

50. Shils ME,
Olson JA.
Modern Nutrition in Health and Disease.
8th ed.Philadelphia, Pa.: Lea & Febiger; 1994.

51. McKevoy GK.
, ed. AHFS Drug Information.
Bethesda, Md.: American Society of Health-System Pharmacists; 1998.

52. ConsumerLab.com. Multivitamin/multimineral supplements. http://www.consumerlab.com/results/multivit.asp. Accessed January 13, 2009.

53. National Center for Complementary and Alternative Medicine. Magnesium and asthma—clinical trials. http://clinicaltrials.gov/ct2/show/NCT00029510?term=%28NCCAM%29+%5BSPONSOR%5D+%28magnesium%29+%5BTREATMENT%5D&rank=1. Accessed January 13, 2009.

Magnesium oxide: Uses, Interactions, Mechanism of Action

Anaplex Tab Magnesium oxide (50 mg / tab) + Ascorbic acid (40 mg / tab) + Calcium (160 mg / tab) + Iodine (.05 mg / tab) + Nicotinamide (30 mg / tab) + Calcium pantothenate (15 mg / tab) + Phosphorus (75.33 mg / tab) + Potassium chloride (20 mg / tab) + Pyridoxine hydrochloride (40 mg / tab) + Vitamin A palmitate (2000 unit / tab) + Vitamin D (133.33 unit / tab) Tablet Oral Anabolic Laboratories Inc. 1975-12-31 1996-10-02 Canada
Aspirin Plus Stomach Guard Ext.stgth.caplet Magnesium oxide (96.9 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.2 mg / tab) + Magnesium carbonate (52.3 mg / tab) Tablet Oral Sterling Winthrop Inc. 1994-12-31 1996-09-10 Canada
Aspirin Plus Stomach Guard Extra Strength Magnesium oxide (96.95 mg / tab) + Acetylsalicylic acid (500 mg / tab) + Calcium carbonate (246.22 mg / tab) + Magnesium carbonate (52.32 mg / tab) Tablet Oral Bayer Inc Consumer Care 1995-12-31 1998-09-28 Canada
Aspirin Plus Stomach Guard Tab Magnesium oxide (63 mg / tab) + Acetylsalicylic acid (325 mg / tab) + Calcium carbonate (160 mg / tab) + Magnesium carbonate (34 mg / tab) Tablet Oral Sterling Winthrop Inc. 1994-12-31 1996-09-10 Canada
Aspirin With Stomach Guard Magnesium oxide (63 mg) + Acetylsalicylic acid (325 mg) + Calcium carbonate (160 mg) + Magnesium carbonate (34 mg) Tablet Oral Bayer Inc Consumer Care 1997-10-01 2012-07-12 Canada
Aspirin With Stomach Guard Extra Strength – Tab Magnesium oxide (96.9 mg) + Acetylsalicylic acid (500 mg) + Calcium carbonate (246.2 mg) + Magnesium carbonate (52.3 mg) Tablet Oral Bayer Inc Consumer Care 1997-07-07 2012-07-12 Canada
B6 Plus Tab Magnesium oxide (50 mg) + Niacin (20 mg) + Potassium citrate (50 mg) + Pyridoxine hydrochloride (50 mg) + Riboflavin (2.4 mg) + Thiamine (10 mg) Tablet Oral Vita Health Products Inc 1979-12-31 2002-08-01 Canada
C-apnto-B6 Vitamins W Magnesium Tab Magnesium oxide (60 mg / tab) + Ascorbic acid (240 mg / tab) + Calcium pantothenate (500 mg / tab) + Pyridoxine (250 mg / tab) Tablet Oral Metagenics, Inc. 1989-12-31 1996-10-02 Canada
Calcemin Advance Magnesium oxide (40 mg/1) + Calcium carbonate (500 mg/1) + Previtamin D(3) (3 mg/1) + Sodium borate decahydrate (2.45 mg/1) + Zinc oxide (7.5 mg/1) Tablet, film coated Oral Bayer Healthcare Llc. 2016-04-01 Not applicable US
Calcemin Silver Magnesium oxide (40 mg/1) + Boron (2.6 mg/1) + Zinc oxide (7.5 mg/1) Tablet, film coated Oral Bayer Healthcare Llc. 2016-04-01 Not applicable US

Magnesium and Migraine | American Migraine Foundation

The ideal medication for prevention and treatment of migraine would have no side effects, no risk, would be safe in pregnancy, as well as being highly effective while remaining inexpensive. Of course, no such medication exists, but magnesium comes closer than many interventions on all these fronts.

Magnesium oxide is frequently used in pill form to prevent migraine, usually at a dose of 400-500 mg per day. Acutely, it can be dosed in pill form at the same dosage, or given intravenously as magnesium sulfate at 1-2 gm. The most frequent side effect is diarrhea, which can be helpful in those prone to constipation. The diarrhea and abdominal cramping that is sometimes experienced is dose responsive, such that a lower dose or decreasing the frequency of intake usually takes care of the problem.

Magnesium oxide in doses up to 400 mg is pregnancy category A, which means it can be used safely in pregnancy. Magnesium sulfate, typically given intravenously, now carries a warning related to bone thinning seen in the developing fetus when used longer than 5-7 days in a row. This was discovered in the context of high doses being given to pregnant women to prevent preterm labor.

The strongest evidence for magnesium’s effectiveness is in patients who have, or have had, aura with their migraines. It is believed magnesium may prevent the wave of brain signaling, called cortical spreading depression, which produces the visual and sensory changes that are the common forms of aura. Other mechanisms of magnesium action include improved platelet function and decreased release or blocking of pain transmitting chemicals in the brain such as Substance P and glutamate. Magnesium may also prevent narrowing of brain blood vessels caused by the neurotransmitter serotonin.

Daily oral magnesium has also been shown to be effective in preventing menstrually related migraine, especially in those with premenstrual migraine. This means that preventive use can be targeted at those with aura and/or those with menstrually related migraine.

It is difficult to measure magnesium levels accurately, as levels in the blood stream may represent only 2% of total body stores, with the rest of magnesium stored in the bones or within cells. Most importantly, simple magnesium blood levels do not give an accurate measure of magnesium levels in the brain. This has led to uncertainty concerning whether correcting a low magnesium level is necessary in treatment, or whether magnesium effectiveness is even related to low blood levels in the first place. Measurement of ionized magnesium or red blood cell magnesium levels is thought to possibly be more accurate, but these laboratory tests but are more difficult and expensive to obtain.

Because magnesium may not be accurately measured, low magnesium in the brain can be difficult to prove. Those prone to low magnesium include people with heart disease, diabetes, alcoholism, and those on diuretics for blood pressure. There is some evidence that migraineurs may have lower levels of brain magnesium either from decreased absorption of it in food, a genetic tendency to low brain magnesium, or from excreting it from the body to a greater degree than non-migraineurs. Studies of migraineurs have found low levels of brain and spinal fluid magnesium in between migraine attacks.

In 2012, the American Headache Society and the American Academy of Neurology reviewed the studies on medications used for migraine prevention and gave magnesium a Level B rating, that is, it is probably effective and should be considered for patients requiring migraine preventive therapy. Because of its safety profile and the lack of serious side effects, magnesium is often chosen as a preventive strategy either alone, or with other preventive medications.

Magnesium has also been studied for the acute, as-needed treatment of severe, difficult-to-treat migraine. Magnesium sulfate given intravenously was found to be most effective in those with a history of migraine with aura. In those without a history of aura, no difference was seen in immediate pain relief or nausea relief by magnesium, but there was less light and noise sensitivity after the infusion.

Magnesium oxide, in tablet form, is very inexpensive, does not require a prescription, and may be considered as very reasonable prevention in those who have a history of aura, menstrually related migraine, no health insurance, or who may become pregnant. Because of the excellent safety profile of magnesium, any patient who has frequent migraines and is considering a preventive strategy to reduce the frequency or severity of their headaches may want to consider this option and discuss it with their physician.

Deborah Tepper, MD

The Headache Center Cleveland Clinic

Cleveland, OH, USA

How to Take Magnesium for Anxiety or Depression

There are two main factors to consider when choosing a form of magnesium:

  1. Bioavailability, which indicates how much magnesium can be absorbed by the gut.

  2. Access to the brain, as effective forms of magnesium have to be able to cross the protective blood brain barrier surrounding the brain.

The two most commonly prescribed forms of magnesium – magnesium oxide and citrate – have the lowest bioavailability of the various forms. This means that they are more likely to pass through the gut and cause loose stools and diarrhea, so they are best used to relieve constipation. Magnesium salts like carbonate and sulfate have similar issues with absorption.

Based on recent studies, there are certain forms of magnesium that have better bioavailability and ability to cross the blood brain better, making them better treatment options for addressing symptoms of anxiety and depression:

Magnesium Taurate

Magnesium taurate contains an amino acid called taurine, which has a calming, neuroprotective, and anti-inflammatory effect in the brain. Taurine also appears to help the magnesium enter the brain. In addition, it is gentle on the GI tract, making it unlikely to cause loose stool and diarrhea. In a recent study, magnesium acetyl taurate increased brain magnesium levels more than any other form of magnesium.

Magnesium Threonate

This form of magnesium has impressive studies backing its use in mental health conditions and has evidence that it can cross the blood brain barrier. However, it can be more expensive and may require taking 2-3 times more capsules than other magnesium supplements to reach a sufficient therapeutic dose.

Magnesium Glycinate

Glycine is an essential amino acid that has important neurotransmitter functions in the brain. Glycine supplementation can improve the quality of sleep, making this form of magnesium a good choice for those with insomnia. Preliminary research shows that magnesium glycinate can elevate levels of magnesium in brain tissue. Like magnesium taurate, the glycinate form is gentle on the GI tract.

Magnesium Malate

This is one of the better absorbed forms of magnesium, which increases both serum and muscle levels of magnesium. Preliminary research shows that it may be effective in treating symptoms of fibromyalgia and chronic fatigue, as malate is involved with energy production.

Based on current data, magnesium taurate and glycinate have the most research supporting their effects on anxiety and other mental health disorders. Magnesium malate and threonine have also demonstrated therapeutic effects and may be useful in many psychiatric cases.

Magnesium Citrate and Oxide: Benefits, Dosage and Side Effects

[Last updated 14th August, 2018]

Magnesium is an essential mineral thought to several potential health benefits.

This ranges from improving energy levels to treating constipation.

This article explores the uses and possible side effects of the most common forms, magnesium citrate and magnesium oxide.

Why is Magnesium Essential?

Magnesium is critical for many processes in the body, including energy metabolism, DNA production and bone structure.

The body contains around 25-30 grams of magnesium. Half is stored in your bones, the other half in muscles and soft tissue. As little as 1% is found in extracellular fluid (1, 2).

Dietary sources of magnesium include green leafy vegetables, legumes, almonds and many other fruits and vegetables.

Magnesium can also be taken orally as a supplement or medication.

Summary: Magnesium is critical for energy metabolism, DNA production and bone structure.

What is Magnesium Citrate?

Magnesium citrate is elemental magnesium bound to a citrate salt.

When magnesium is bound to a citrate salt it’s more easily dissolved and absorbed by the body. This is why it’s often used in magnesium supplements and laxatives.

As a Supplement

Magnesium citrate supplements prevent or treat magnesium deficiency.

They are generally taken in tablet form.

As a Laxative

It can also be used as a laxative or to flush out the colon prior to operations.

It works by drawing water into the bowel to induce bowel movements. As a laxative, it’s most commonly taken as a liquid.

You may also see magnesium citrate on food labels as an additive; it will be listed as e345. This form is used as an acidity regulator.

Summary: Magnesium citrate is elemental magnesium bonded to citric acid. It can be used as a magnesium supplement or laxative.

What is Magnesium Oxide?

Magnesium oxide (MgO) is a naturally occurring inorganic compound.

It’s used as an osmotic laxative, much like magnesium citrate. It may also be taken as an antacid.

When magnesium oxide combines with water, magnesium hydroxide is formed. This compound is able to naturalize acid in the gastrointestinal tract (4).

One study of 276 participants found that a product called Carbosymag — a combination of simethicone, activated charcoal and magnesium oxide — was 70% more effective than a placebo for treating symptoms of indigestion.

However, it’s likely these results were due to all of the ingredients acting together, rather than the magnesium oxide itself (5).

A number of antacids use magnesium hydroxide combined with other substances. Unfortunately, there are very few recent studies looking at the effectiveness of magnesium alone as an antacid.

Magnesium oxide can also be used as an anti-caking agent. It will be listed on food labels as e530.

Summary: Magnesium oxide is an inorganic compound often used as a laxative and in antacids.

Magnesium Oxide vs Magnesium Citrate Supplements

Magnesium oxide contains the highest amount of elemental magnesium (about 60%) of all magnesium supplement types.

However, this doesn’t directly translate to more magnesium absorbed in the body.

In fact, magnesium oxide is poorly absorbed by the body. It’s though that around 4% of its elemental magnesium is absorbed, equivalent to about 9.5 mg out of a 400 mg tablet (with 60% elemental magnesium) (16).

On the other hand, magnesium citrate is much better absorbed by the body than magnesium oxide. It appears to have a bioavailability of 25-30% (17).

For this reason magnesium citrate is the most common type of magnesium supplementation and is the recommended choice for most issues and deficiencies.

Summary: Magnesium oxide has more elemental magnesium per gram, but is not absorbed as well as magnesium citrate in the body.

Can You Be Deficient in Magnesium Citrate or Magnesium Oxide?

Magnesium citrate and magnesium oxide are compounds not required by the body, but magnesium itself most certainly is.

The absorption of magnesium is dependent on how much of the mineral is already stored in the body.

When the body has sufficient magnesium, less of it is absorbed from food and supplements. When stores are low, more magnesium will be absorbed (6).

Magnesium deficiency is difficult to detect and test. You are unlikely to experience many symptoms until your body’s magnesium stores are severely depleted (2).

Normal blood magnesium levels are 0.70 -0.95 mmol/L. Hypomagnesemia, or low blood magnesium, is defined when blood levels of magnesium are less than 0.70 mmol/L. This is thought to be a good indicator of total body magnesium depletion.

However, less severe and non-symptomatic magnesium deficiency is not as accurately reflected in blood tests (2).

This is because blood levels of magnesium do not account for the stores in bone and other tissues, where the majority of magnesium is found.

If you have one of the following conditions, you are more likely to be deficient in magnesium:

  • Obesity (6, 7)
  • Type 2 diabetes (8)
  • Alcoholism (9)
  • Chronic kidney disease (6)
  • Digestive diseases and disorders. Chronic diarrhea and malabsorption can lead to reduced absorption of magnesium in the gastrointestinal tract (6, 7).

Certain medications may also increase the likelihood of magnesium deficiency (6, 7).

Summary: The body requires magnesium, but not in the form of compounds like magnesium citrate and magnesium oxide. Certain pre-existing conditions increase the likelihood of magnesium deficiency.

Treating Magnesium Deficiency

Magnesium citrate is one of the most common forms of magnesium used to treat deficiency.

It has a high bioavailability of 25-30%, which means it’s more readily absorbed by the body, and is highly soluble in water (9).

Two different studies found that magnesium citrate was better absorbed, in both acute and long-term supplementation, compared to other magnesium supplements (10, 11).

Magnesium oxide has a much lower bioavailability and is less soluble (9).

However, this does not mean it can’t be used as a supplement. In fact, one study found that magnesium oxide was able to raise levels of intracellular (inside tissue cells) magnesium just as well, if not better, than magnesium citrate (12).

Summary: Though magnesium citrate is more soluble in water and has a higher bioavailability, magnesium oxide is just as suitable as a magnesium supplement.

Magnesium and Constipation

Both magnesium citrate and magnesium oxide can be used as an osmotic laxative.

When taken, water is drawn into the large intestine via a process called osmosis. The large intestine then becomes full of water, softening stool and stimulating bowel movements (13).

According to anecdotal accounts, magnesium citrate is a quick and effective treatment for constipation.

However, there’s still limited evidence to suggest that magnesium-based laxatives are more effective than other type of laxatives (14).

Magnesium may also be taken for bowel preparation. This is when the bowel needs to be cleared out before a gastrointestinal operation or procedure (15).

Summary: Magnesium citrate and magnesium oxide can be used as a laxative and to clear out the bowel before medical procedures.

Are Other Reported Magnesium Benefits and Uses True?

Magnesium citrate and magnesium oxide are often promoted as a cure-all for an assortment of conditions.

The list of conditions is very broad and there is very little or no evidence available to support these claims:

  • Stress and anxiety: Current evidence is poor and inconclusive (18)
  • Muscle aches and cramps: Possibly useful for treating leg cramps during pregnancy but not all aches and cramps.
  • Insomnia: Some evidence does suggest magnesium can help with sleep however, it is unlikely to help with sever insomnia.
  • Respiratory issues: may be helpful for asthma but cannot be generalised to all respiratory issues.
  • Poor digestion, such as IBS
  • Back pain
  • Prevention of heart attacks
  • Nausea and dizziness
  • Irregular heart beat
  • Panic attacks
  • Loss of appetite
  • Fatigue (more on this below)

The problem is it’s very hard to tell whether magnesium will actually help with these problems in people who are otherwise healthy. Some reasons for this include:

  • The extremely wide range of non-specific symptoms associated with magnesium deficiency.
  • The symptoms of magnesium deficiency can be also present in a number of other health conditions.
  • The difficulty in testing for low grade magnesium deficiency. As discussed above the full spectrum of symptoms may not appear until severe deficiency occurs. This makes symptoms of mild deficiency hard to pinpoint.

At this stage, those claims are all speculative and hopeful.

Magnesium and Fatigue

Fatigue is probably the most popular condition that magnesium supplements are said to remedy.

But its unknown if fatigue is actually a symptom of mild magnesium deficiency.

Some studies suggest magnesium might be beneficial to people with chronic fatigue or fibromyalgia, but they are far from conclusive (16).

It could be worth a try, but it’s speculative at the moment.

Summary: Magnesium is said to be a cure-all for many conditions ranging from muscle aches to digestive issues and even fatigue. The evidence supporting these claims is largely non-existent, so it remains to be seen if it is useful for these conditions.

What Dosage of Magnesium Should I Take?

The magnesium dosage depends on your age and what you’re taking magnesium for.

For Deficiency

The National Institutes of Health recommend not exceeding the following doses of magnesium from supplements or medication:

  • 1-3 years = 65mg/day
  • 4-8 years = 110mg/day
  • 9-18 years = 350mg/day
  • Adults = 350mg/day

For Constipation

Most manufacturers recommend 150-300ml of magnesium citrate.

For magnesium oxide, most suggest one 500mg tablet, twice per day, with a full glass of water.

Overall, it’s best to follow the instructions on the label or from your doctor.

For Indigestion

The dose depends entirely on the type of medication you are taking. Consult your pharmacist or doctor.

Magnesium Side Effects

Magnesium citrate and magnesium oxide generally have few side effects.

However, some people may experience diarrhea and stomach discomfort.

If it’s continually used as a laxative you may develop laxative dependence. This is when the bowel loses its ability to effectively clear stools without the help of a laxative.

In rare circumstances, hypermagnesemia (too much magnesium in the blood) can occur, usually only when large doses are given for bowel preparation or with long-term use.

Consult your doctor if you are taking antibiotics, as magnesium supplementation may reduce their effect.

Magnesium should be taken with caution if you have any of the following conditions (6):

  • Kidney disease
  • Ongoing nausea and vomiting
  • You are on a low-sodium or low-magnesium diet

Summary: Magnesium supplementation has few side effects. The most common is digestive issues like stomach discomfort and diarrhea.

Should I Take a Magnesium Supplement?

Dietary sources of magnesium should be your first go-to source for increasing magnesium intake.

Foods high in magnesium include:

If you believe you’re not able to get enough through your diet, you may consider a magnesium supplement.

Get the full run-down on magnesium supplements here.

Magnesium Plus 30 tablets – Russian Pharmacy in Sharm El Sheikh

Trade name:

Magnesium Plus

Magnesium Plus


Each tablet contains:

Magnesium oxide – 400mg.

Magnesium gluconate – 100mg.


Magnesium is the second most abundant intracellular cation. It is a cofactor in more than 300 enzymatic reactions, including proteins of energy metabolism and nucleic acid products.Oral magnesium salt formulations are used as a supplement in patients with magnesium deficiency due to a restricted diet, alcoholism or magnesium depletion caused by drugs that break down magnesium (such as diuretics), or severe burns and regular exercise that increase magnesium production with sweat. Magnesium oxide can also be used as an antacid or laxative. The antacid mechanism of magnesium oxide involves reaction with water. In the presence of water, magnesium oxide is converted to magnesium hydroxide, which quickly reacts with stomach acid to form salt and magnesium chloride, thereby increasing gastric pH.


Adjuvant therapy during diuretic treatment and in severe burns. Treatment of hypomagnesemia. For muscle cramps as a result of magnesium depletion. As a laxative for the treatment of constipation or as a bowel preparation before surgery or radiological, proctoscopic and sigmoidoscopic procedures. For the treatment of indigestion and heartburn.

Application method:

For the treatment of hypomagnesemia, adjuvant therapy and symptoms caused by magnesium depletion, 1-2 tablets per day, tolerated without diarrhea.For laxative effect or bowel preparation for research: 1 tablet at bedtime with a full glass of water. For the treatment of dyspepsia: 1 to 2 tablets daily.


Use with caution in patients with renal insufficiency. When used as laxatives, oral magnesium salts should be avoided in patients with gastric or intestinal obstruction. Use oral magnesium salts with caution in dehydrated patients.Repeated administration of oral magnesium salts can lead to severe dehydration due to fluid loss through the gastrointestinal tract.


Take any other medicines and magnesium oxide at least 2 hours apart. Do not take magnesium as an antacid for more than 2 weeks unless directed by your doctor. Do not take magnesium oxide as a laxative for more than 1 week unless directed by your doctor.

Side effects:

Diarrhea is the most common reaction with oral magnesium salts.

Drug interaction: the simultaneous use of cardiac glycosides with magnesium salts can inhibit absorption and, possibly, reduce the concentration of cardiac glycosides in plasma. Diuretics can affect the concentration of magnesium in the kidneys. Concomitant use of laxatives can lead to magnesium toxicity, especially in patients with renal impairment. Administration of oral magnesium salts with oral tetracyclines or quinolone antibiotics may involve magnesium supplementation with other magnesium-containing antacids, or form absorbable complexes, resulting in decreased absorption of tetracyclines and non-quinolones.Do not give magnesium salts by mouth within 1 to 3 hours after taking oral tetracycline or oral fluoroquinolone. Magnesium antacids and supplemental magnesium salts should not be used in the preparation of vitamin D analogs. Increase serum magnesium levels in patients with chronic renal failure.

Pregnancy and lactation: Do not use during pregnancy without consulting a doctor. Magnesium crosses the placenta and is excreted in breast milk.


Store at a temperature not exceeding 30C in a dry place out of the reach of children.


Box contains 30 tablets and paper instructions.

Doppelgerz® active Magnesium + Vitamins of group B

Who is recommended to take Doppelherz Active Magnesium + Vitamins of Group B?

The trace element magnesium is important for the energy supply of cells, metabolic processes, and stabilization of the work of the heart muscle.He takes part in the process of neuromuscular arousal. At the same time, it is contained in the body in extremely small quantities. Vitamin B6 is used in the treatment of neurological disorders, impaired attention, and depression. Vitamin B1 is involved in metabolic processes and supports the normal functioning of the nervous system. Vitamin B12 is used for the treatment and prevention of anemia, protects against the development of heart attack and stroke, and normalizes the functioning of the nervous system.

Thus, this complex is recommended for people with magnesium deficiency, which is accompanied by the following symptoms:

  1. Fatigue, lethargy, low energy level
  2. Increased nervousness
  3. Chronic fatigue syndrome

What is chronic fatigue syndrome?

To establish the diagnosis of Chronic Fatigue Syndrome, two prerequisites are required:

  1. Persistent fatigue that significantly reduces the level of activity for at least 6 months.
  2. At least 4 of the following symptoms:
    • Impaired memory or concentration;
    • sore throat;
    • enlarged lymph nodes;
    • Muscle pain or stiffness
    • joint pain;
    • re-emerging headache;
    • sleep that does not bring recovery of strength;
    • fatigue after exercise.

There must be no other pathology that could explain this condition (eg anemia).
Clinical studies have confirmed the positive therapeutic effect of a combination of magnesium (lactate) and vitamin B6 (pyridoxine hydrochloride) on the severity of symptoms characteristic of chronic fatigue syndrome [1,2].

[1] Gromova OA .. Avdeenko TV, Burtsev EM, 1998

[2] Mousain-Bosc M., Roche M., Rapin J et al., 2004).

Antistress set 1 set


The Antistress set is suitable for everyone who, against the background of increased psycho-emotional stress, experiences digestive problems (bloating, heaviness after eating, pain, problems with stools, etc.).NS.).

The set includes:
7 Magnesium Salts® – a unique best-selling Biogena product! It can be used to effectively prevent stress. It contains seven forms of magnesium based on organic salts with high bioavailability and the ability to be absorbed at various pH levels. Magnesium can help improve sleep, improve performance, relieve irritability, and reduce anxiety.

“Fit @ Work® Stressbiotic” – directed and gently helps to restore the balance of the microbiome (studies have shown that the diversity and well-being of the intestinal microflora especially affects the production of serotonin, which means it can be a support in times of stress).It contains the patented Probiostress® complex with lacto, bifidobacteria and saffron extract, vitamin C and riboflavin (to support energy levels).


7 Magnesium® Salt

capsule daily dose in 2 capsules
Magnesium 140 mg 280 mg

Ingredients: magnesium malate, magnesium bisglycinate, hydroxypropyl methylcellulose (capsule shell), magnesium citrate, magnesium oxide, magnesium glycerophosphate, magnesium gluconate, magnesium carbonate. Fit @ Work® Stressbiotic

daily dose in 1 capsule
Probiostress ™ 500 mg
contains: lactobacilli and bifidobacteria 1,000,000,000 CFU / g
contains: saffron extract 30 mg
Vitamin C 80 mg
Riboflavin (vitamin B2) 1.4 mg

Composition: Filler: magnesium hydroxide; hydroxypropyl methylcellulose (capsule shell), calcium ascorbate, saffron extract, lactobacillus and bifidobacteria, riboflavin. May contain trace amounts of soy and milk.

Dietary supplement. It is not a medicine. The recommended daily intake should not be exceeded. Not a substitute for a balanced and varied diet. The information provided is not a recommendation for treatment.Consult a specialist before use.
Suitable for diabetics.

Pure matter principle
To create micronutrients, Biogena uses “pure substances” completely free from dyes, preservatives, anti-adhesives, artificial flavor enhancers, anti-caking agents, excipients.


Magne B6®

By Order of the Chairman
RSU “Medical Committee
and pharmaceutical control
Ministry of Health
Of the Republic of Kazakhstan “
from “17” ___05____2021
No. N039106

Instruction for medical use

of medicinal product
(Package leaflet)

Trade name


International Nonproprietary Name


Dosage form, dosage

Film-coated tablets

Pharmacotherapeutic group

Digestive tract and metabolism. Mineral supplements. Other minerals. Magnesium preparations. A combination of various magnesium salts.
ATX code A12CC30

Indications for use

Established magnesium deficiency, isolated or associated.
A combination of the following may indicate a magnesium deficiency:
– nervousness, irritability, mild anxiety, transient fatigue, minor sleep disturbances
– signs of anxiety such as gastrointestinal cramps or heart palpitations (without any pathology from the heart), / br>
– muscle cramps, tingling sensation in the muscles

List of information required before starting use

– hypersensitivity to active ingredients or to any of the excipients
– severe renal failure (creatinine clearance less than 30 ml / min / 1.73 m2)
– simultaneous administration with levodopa is not recommended due to the pyridoxine content in the preparation
-severe violations of the water-salt balance
-Children under 6 years old
– rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.

Precautions to be taken when using

-In case of severe magnesium deficiency, treatment should be started with parenteral administration of the drug, and parenteral administration is also recommended for patients with severe malabsorption syndrome.
-If there is concomitant calcium deficiency, magnesium deficiency should be corrected first before supplementing with calcium.
-In the case of mild to moderate renal failure, the patient can receive treatment with a reduced dose of the drug with careful monitoring of the level of magnesium in the blood plasma (to prevent the risk of hypermagnesemia of any etiology).
– An increase in the level of magnesium affects the work of the heart, slightly lowering blood pressure, slows down the conduction of the heart impulse, can weaken cardiac function, therefore, the drug can be prescribed to digitalized patients, only under close medical supervision (ECG monitoring, drop in blood pressure).
– The main effect of chronic pyridoxine overdose is sensory, axonal neuropathy, which can occur if high doses of pyridoxine are taken for a long period of time (several months, and in other cases for many years), but this can also occur with small doses (50-300 mg / day). Symptoms include numbness and impaired sense of body position, tremors in the distal extremities, and gradual progressive sensory ataxia (impaired coordination of movements).This effect is usually reversible upon discontinuation of pyridoxine.
-This medicinal product should not be prescribed to patients with rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.
-Film-coated tablets are intended for the treatment of adults and children over 6 years of age.
Interactions with other medicinal products
Combinations to which there are contraindications
– Simultaneous administration with levodopa should be avoided, since the activity of levodopa is peripherally inhibited by vitamin B6, if the administration of this drug is not combined with the administration of peripheral dopa decarboxylase inhibitors, and levodopa cannot cross the blood-brain barrier.Thus, the action of levodopa is suppressed.
Combinations not recommended
– Simultaneous administration of preparations based on phosphates or calcium salts and preparations containing iron II ions is not recommended, since such products interfere with the absorption of magnesium in the intestine.
Combinations to be used with caution
– In case of concomitant treatment with oral tetracyclines, bisphosphonates, digitalis glycosides and sodium fluoride, when taking MAGNE B6® film-coated tablets, an interval of at least 3 hours must be observed after taking any of these drugs, since magnesium reduces their absorption in the gastrointestinal tract.
Special warnings
During pregnancy or lactation
Due to the lack of available data on the safety of use in pregnant or lactating women, it is not recommended to exceed the maximum recommended therapeutic doses (i.e. the recommended daily intake of each of the components, namely magnesium: 250 mg / day; RDA for vitamin B6: 25 mg / day).
Peculiarities of the drug’s effect on the ability to drive a vehicle or potentially dangerous machinery
Not established

Recommendations for use

Dosing regimen
Adults: 4-6 tablets, divided into 2-3 doses per day.Adolescents over 14 years of age (weighing> 50 kg) can take the drug as adults.
Children: Film-coated tablets should not be given to children under 6 years of age.
For children over 6 years old (body weight> 20 kg), magnesium should be prescribed at 5-10 mg / kg / day, that is, 2-4 tablets per day, dividing them into 2-3 doses.
Method and route of administration
For oral administration. The tablets should be swallowed whole with plenty of water after meals.
Treatment duration
Treatment should be continued until the symptoms of magnesium deficiency have disappeared.
Measures to be taken in case of overdose
Long-term use of large doses can lead to hypermagnesemia. An overdose of magnesium when taken orally does not lead to toxic reactions in patients with normal renal function. Magnesium poisoning may develop in patients with renal insufficiency.
The toxicity level depends on the concentration of magnesium in the blood and can cause the following signs and symptoms:
– drop in blood pressure
– nausea, vomiting
– depression of the central nervous system, impaired reflexes
– pathological changes on ECG
– development of respiratory depression, coma, cardiac arrest and respiratory paralysis
– anuria
Treatment: rehydration, forced diuresis.Renal failure requires hemodialysis or peritoneal dialysis.
Recommendations for seeking the advice of a healthcare professional to explain how to use the medicinal product

If you have any questions about the use of this medicinal product, please contact your doctor or pharmacist.

Description of adverse reactions that occur with the standard use of the medicinal product and the measures to be taken in this case

– diarrhea
– abdominal pain
Very rare

– allergic reactions
Not known

-cutaneous reactions

In the event of adverse drug reactions, contact a healthcare professional, pharmacist or directly to the information database on adverse drug reactions (actions), including reports of drug ineffectiveness

RSE on REM “National Center for Expertise of Medicines and Medical Devices” of the Committee for Medical and Pharmaceutical Control of the Ministry of Health of the Republic of Kazakhstan
http: // www.ndda.kz

Additional information

Composition of the medicinal product

One tablet contains
active substances: magnesium lactate dihydrate – 470 mg (equivalent to 48 mg magnesium), pyridoxine hydrochloride – 5 mg
excipients: sucrose, heavy kaolin, acacia gum, carbomer 35000 mPa.s, talc, magnesium stearate
shell composition: acacia gum, sucrose, titanium dioxide, talc, carnauba wax.

Description of appearance, smell, taste

White coated tablets, smooth, shiny, oval

Form of issue and packaging

10 tablets are placed in blisters made of polyvinyl chloride film and aluminum foil.
5 contour packs, together with instructions for medical use in the state and Russian languages, are put into a cardboard box.

Shelf life

2 years
Do not take after expiration date.
Storage conditions
Store at a temperature not exceeding 30 ℃.
Keep out of the reach of children!

Terms of dispensing from pharmacies

Without prescription

Manufacturer information

HINOIN, pharmaceutical and chemical products plant ZAO, Hungary
2112 Veresegyhaz, Levai u.5, Hungary
Tel: +1 212-652-2655
[email protected]

Marketing Authorization Holder

Sanofi-aventis ZAO, Budapest, Hungary
1045 Budapesht, To u.1-5, Hungary
Tel: +36 1 505 2142

Name, address and contact details (phone, fax, e-mail) of the organization on the territory of the Republic of Kazakhstan that accepts claims (proposals) on the quality of medicinal products from consumers and is responsible for post-registration supervision of the safety of the medicinal product

Sanofi-aventis Kazakhstan LLP
050013, Almaty, N. Nazarbayev ave., 187B
Tel .: +7 (727) 244 50 96/97
Email address: [email protected]
[email protected]
Solution: N039106
Decision date: 17.05.2021
Surname, name, patronymic (if any) of the head of the state body (or an authorized person): B. Bayserkin S.
(Committee for Quality Control and Safety of Goods and Services)
This document, in accordance with clause 1 of Article 7 of the ZRK dated January 7, 2003 “On an Electronic Document and Electronic Digital Signature”, is equivalent to a paper document


Appearance and properties: oblong tablets, white colors,

Nutritional and energy value: 1 capsule contains 0.5 kcal, 2 kJ, proteins 0 mg, fats 36 mg, carbohydrates 0 mg.

Directions for diabetics: Does not contain bread units.

Magnesium is a vital mineral that is contained in the body in extremely small quantities. The amount of magnesium received from food does not always compensate for its loss. Magnesium is extremely important for the energy supply of the cells of the body, activates enzymatic reactions, and participates in metabolic processes. Magnesium largely determines the normal activity of the heart, controls the functioning of myocardial cells, stabilizes the heart rate, helps relieve spasm of blood vessels, thereby improving blood circulation.

Magnesium takes part in the process of neuromuscular excitation, it has an anti-stress effect, magnesium deficiency aggravates the course of mental disorders. Magnesium is also beneficial for intense physical and mental stress.

B vitamins are primarily responsible for the production of energy from dietary carbohydrates, proteins and fats, but each of them has its own main function.

Vitamin B1 (thiamine) – participates in metabolic processes, supports the normal functioning of the nervous system, improves memory and clarity of thought.Deficiency of vitamin B1 in the body occurs in cases of poor absorption in the intestine, insufficient absorption of this vitamin by cells, as well as with its increased destruction and increased consumption.

Vitamin B6 (pyridoxine) – participates in many biochemical reactions, in particular, it is necessary for the production of prostaglandins. Pyridoxine helps to stabilize blood sugar levels, improves glucose metabolism. Vitamin B6 is useful in diseases of the cardiovascular system, lowers blood pressure, and plays an important role in maintaining immunity.Pyridoxine is often used for neurological disorders, impaired memory, attention, and depression.

Vitamin B12 (cyanocobalamin) – promotes the absorption of food, protects against the development of heart attack and stroke, normalizes the nervous system. Normal emotional and cognitive (cognitive) brain function depends on having optimal levels of vitamin B12. It helps to overcome insomnia, improves falling asleep and increases sleep duration.

Folic acid is a water-soluble B vitamin.In combination with vitamins B6 and B12, folic acid takes part in protein synthesis, the formation of red blood cells, and also in the transfer of oxygen. Folic acid is involved in the biochemical processes responsible for brain health and emotional balance and is very useful in preventing cardiovascular disease. This acid is also essential for the health and normal reproduction of intestinal cells.

Chelated magnesium (or magnesium bisglycinate, aka glycinate)


Magnesium Glycinate 400, 400 mg, 180 Tablets

Why are CHELATES so great? This form of magnesium is completely ready for absorption by the intestinal walls, it does not require additional transformations in the body with the involvement of other elements, so chelated forms give quick results.(Such magnesium is more expensive than others, since production technologies are more complex).

The advantage of magnesium glycinate is that it is completely comfortable for digestion and does not have a laxative effect (like L-threonate).

And these good quality chelates (by the way, bisglycinate = glycinate = chelate):

CGN magnesium bisglycinate 200 mg, in capsules

Solaray, Magnesium glycinate, 400 mg, 120 capsules

Bluebonnet Nutrition, Chelated Magnesium , 120 Veggie Caps

Kirkman Labs, Magnesium Bisglycinate Chelate , Bio-Max Series, 250 Capsules

Thorne Research, Magnesium Bisglycinate Chelate

, 8.4 oz.

If someone does not use magnesium on a daily basis and does not know why he walks in the main elements for the normal functioning of the whole body.

• Magnesium is responsible for the assimilation of many substances, it participates in more than 300 biological reactions. With its deficiency, the nervous system, bone tissue suffers, gastrocnemius cramps, insomnia, depression and even panic attacks appear (and we thought it was a terrible genetic disease, yes ..). (Research 1 , 2 , 3 )

• Magnesium is involved in the synthesis of serotonin – mood substances , and other neurotransmitters, with its lack there are chronic headaches, migraines, depression and anxiety, not for nothing many the names of magnesium preparations include the word “calm”.(Research)

• With a lack of magnesium, biotin is poorly absorbed, and this is dry, faded skin, bad hair and nails. (Research)

• Magnesium affects the normal functioning of the brain, mental capabilities, and the opposition of brain cells to degenerative processes, including age-related ones. (Form Magnesium L-threonate is designed specifically to support the brain and nervous system during high mental stress and in old age) (Research)

during pregnancy.Most of the doctors’ recommendations for hormonal disorders and various female diseases begin with magnesium. (Research 1 , 2 , 3 , 4 )

• Magnesium is an excellent pressure stabilizer, it is possible that other drugs will not be needed besides it. (Research)

• For diabetes mellitus and for its prevention. (Study, 2 )

• In diabetic neuropathy, magnesium protects the nervous tissue that is attacked by sugar.(Research)

• Magnesium reduces stress levels, it is extremely necessary for children, adolescents, students during the session, although it should be taken every day, and not during something. This is an element that is very quickly excreted from the body (especially under stress) and requires constant replenishment. (Research) – This research provides information for those who doubt whether children need supplements if they have the right nutrition.

• Which organ contains the most magnesium? In heart.A fiery motor needs a building material, as does the entire cardiovascular system (Study, 2 )

• Magnesium is essential for controlling asthma, it is responsible for relaxing muscles – including bronchial muscles.

• It also helps the body synthesize a special growth factor, thanks to which muscle tissue develops and grows well.

What is more important than CALCIUM or MAGNESIUM?
Not calcium. Balance matters! In the body, these two elements strive to fill each other’s place.There is a persistent myth that you need a lot of calcium every day (supposedly due to a lack of calcium, nails exfoliate and bones are bad), this is NOT so, calcium is essentially “cement”, and, knocking down the balance in the direction of calcium, we cement the tissues, which must remain elastic.
In fact, the nails are likely to exfoliate due to a lack of magnesium. without it, biotin is not assimilated, as I wrote about above.
For building bones, again, magnesium is important, it affects the absorption of calcium.

Magnesium is important for digestion and the entire gastrointestinal tract, it attracts water to the intestines, which affects peristalsis and relieves constipation. magnesium citrate is used as a light laxative, magnesium oxide is used as a more effective one, but the absorption of magnesium itself in citrate is lower, and in oxide it is about zero (but it is an excellent laxative).

If you find magnesium oxide in advanced bone complexes, keep in mind that it is not there as a source of magnesium. The fact is that it is magnesium oxide and vitamin K2 that affect the absorption of calcium and its direction into the bone tissue (so that it does not wander around the body and does not settle in the vessels and kidneys).

Further, what do blood tests say about magnesium reserves in the body, i.e. whey magnesium. Alas, they are not very informative – for example, hemoglobin and serum iron do not tell us about iron stores in the body, just as these indicators of magnesium do not carry the necessary information.
A lowered serum magnesium level indicates an acute deficiency of this element,
but normal does not indicate the absence of this deficiency,
everything is the same with iron – when it comes to reducing serum iron, then this is not just a deficiency, but most likely anemia.(With very low ferritin, serum iron and hemoglobin can be completely normal)

If you want to determine the level of magnesium, and along with many other trace elements, you need to do a spectral analysis of the hair.
Almost everyone has a magnesium deficiency; it is the element that is flushed out of the body constantly and at high speed, therefore 400 mg for an adult. a day is a safe dosage.

As for the composition of blood and analyzes for many, many substances.Why you need to venture with spectral analysis of hair, saliva and other special.
The blood formula is a very constant structure, for some elements the value can fluctuate in a very, very narrow range. If the value changes negligibly more, then we become seriously ill, therefore it is so arranged that the blood will take trace elements from anywhere – it lacks calcium – it will take it from the bones (will produce resorption), magnesium is needed – it will take it from muscles and nervous tissue. Blood is needed for us to survive, and convulsions, etc.- the second question.

There are insufficient data on transdermal application of magnesium (research).
Information is conflicting. For example, the Israeli army uses a protective magnesium lotion IB1, its effects have been investigated, no changes in magnesium levels have been found. On the other hand, magnesium baths and the use of magnesium oil on a regular basis are able to maintain serum magnesium levels systematically, which means that cellular magnesium levels will rise over time.
“In addition, it was reported that the radius of the ion of hydrated magnesium (86 microns) is 400 times higher than its dehydrated form, which leads to the statement that magnesium ions practically do not pass through biological membranes”

This is an incomplete list of the needs of this element for every day …

As for the blood test for the level of magnesium in the body, you can read here

Update 11/15/17: magnesium + calcium (two in one) in chelated form here

If you have high blood pressure, then will do such a preparation of magnesium .

Note : and here Lara writes that magnesium citrate is important for those with kidney stones

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Pyatigorsk Medical and Pharmaceutical Institute – a branch of Volgograd State Medical University

According to the Order of the Ministry of Health and Social Development of the Russian Federation No. 434 of April 28, 2012, on October 1, 2012, the reorganization of the state budgetary educational institution of higher professional education “Volgograd State Medical University” of the Ministry of Health and Social Development of the Russian Federation and the state budgetary educational institution of higher professional education was completed “Pyatigorsk State Pharmaceutical Academy” of the Ministry of Health and Social Development of the Russian Federation in the form of joining the second institution to the first with subsequent formation on the basis of the affiliated institution of a separate subdivision (branch).

It was determined that the full name of the branch of the university (the former Pyatigorsk State Pharmaceutical Academy), taking into account the division of the Ministry of Health and Social Development of the Russian Federation into two ministries, is as follows:

Pyatigorsk Branch of the State Budgetary Educational Institution of Higher Professional Education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation

Abbreviated name: “Pyatigorsk branch of the Volgograd State Medical University of the Ministry of Health of Russia” .

According to the Order of the Ministry of Health of the Russian Federation No. 51 of February 4, 2013, changes are indicated that are being made to the charter of the state budgetary educational institution of higher professional education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation.

In clause 1.10, paragraphs three and four shall be stated as follows:

“Full name: Pyatigorsk Medical and Pharmaceutical Institute – a branch of the state budgetary educational institution of higher professional education” Volgograd State Medical University “of the Ministry of Health of the Russian Federation “,

abbreviated name:

Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University of the Ministry of Health of Russia “.

Renaming was carried out from 03/14/2013.

In accordance with the order for the University of July 15, 2016 No. 1029-KM “On the introduction of a new version of the Charter and change of the name of the University” from 13.07.2016 in connection with the renaming of the University, consider:

the full name of the University: Federal State Budgetary Educational Institution of Higher Education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation;

– the abbreviated name of the University: FGBOU VO VolgGMU of the Ministry of Health of Russia;

full name of the branch of the University: Pyatigorsk Medical and Pharmaceutical Institute – a branch of the federal state budgetary educational institution of higher education “Volgograd State Medical University” of the Ministry of Health of the Russian Federation;

– the abbreviated name of the branch of the University: Pyatigorsk Medical and Pharmaceutical Institute – a branch of the Volgograd State Medical University of the Ministry of Health of Russia.