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Magnesium oxide 400mg side effects. Magnesium Oxide Side Effects, Dosage & Uses: Comprehensive Summary

What are the side effects of magnesium oxide 400mg? What is the dosage and how should magnesium oxide be used? Find comprehensive information on the uses, side effects, interactions, and more for this mineral supplement.

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Magnesium Oxide: An Essential Mineral Supplement

Magnesium oxide is a mineral supplement used to prevent and treat low levels of magnesium in the blood. It plays a crucial role in the normal functioning of cells, nerves, muscles, bones, and the heart. While a well-balanced diet can usually provide adequate magnesium, certain situations can cause the body to lose magnesium faster than it can be replaced from the diet.

Situations Requiring Magnesium Oxide Supplementation

Some circumstances that can deplete magnesium levels include:

  • Treatment with diuretics (water pills) such as furosemide or hydrochlorothiazide
  • Poor diet
  • Alcoholism
  • Severe diarrhea or vomiting
  • Stomach or intestinal absorption problems
  • Poorly controlled diabetes

How to Use Magnesium Oxide Properly

To use magnesium oxide effectively, follow these guidelines:

  1. Take the product by mouth as directed, following all instructions on the package.
  2. It is best to take magnesium supplements with a meal to reduce stomach upset and diarrhea, unless otherwise directed.
  3. Take each dose with a full glass (8 ounces or 240 milliliters) of water, unless your doctor instructs otherwise.
  4. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew them.
  5. If using chewable tablets, chew each one thoroughly before swallowing.
  6. For liquid products, use a medication measuring device to ensure the correct dose. Do not use a household spoon.
  7. Take this medication regularly to get the most benefit from it, and remember to take it at the same time(s) each day.
  8. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed, as too much magnesium in the blood can cause serious side effects.

Potential Side Effects of Magnesium Oxide

The most common side effects of magnesium oxide are stomach upset and diarrhea. These effects can be reduced by taking the supplement with a meal. If these side effects persist or worsen, inform your doctor or pharmacist.

A very serious allergic reaction to magnesium oxide is rare, but you should seek medical help immediately if you notice any symptoms of a severe allergic reaction, such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

Precautions and Interactions

Before taking a magnesium supplement, tell your doctor or pharmacist if you have any allergies, especially to magnesium. Some forms of this product may contain inactive ingredients that can cause allergic reactions or other problems.

Consult your doctor before using magnesium oxide if you have kidney disease. Certain forms of this product may also contain sugar, aspartame, alcohol, or other substances that require caution if you have conditions like diabetes, liver disease, or phenylketonuria (PKU).

Magnesium oxide should be used during pregnancy only when clearly needed, as the effects on the developing fetus are unknown. It is also unknown if this product passes into breast milk, so consult your doctor before breastfeeding.

Drug interactions may change when taking magnesium oxide, so be sure to inform your doctor or pharmacist about all the medications, vitamins, and supplements you are using.

Ensuring Proper Dosage and Monitoring

Tell your doctor if symptoms of low magnesium blood levels, such as muscle cramps, tiredness, irritability, or depression, last or worsen. If you think you may have a serious medical problem, seek medical help immediately.

Remember, it is important to follow the dosage instructions on the product package or as directed by your doctor. Do not increase your dose or take it more often than recommended, as too much magnesium in the blood can lead to serious side effects.

Conclusion

Magnesium oxide is an essential mineral supplement used to prevent and treat low magnesium levels in the blood. While it is generally well-tolerated, it is important to use it as directed, be aware of potential side effects and precautions, and monitor your condition closely. By following these guidelines, you can safely and effectively supplement with magnesium oxide to maintain optimal health.

Magnesium Oxide Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is a mineral supplement used to prevent and treat low amounts of magnesium in the blood. Some brands are also used to treat symptoms of too much stomach acid such as stomach upset, heartburn, and acid indigestion. Magnesium is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well-balanced diet provides normal blood levels of magnesium. However, certain situations cause your body to lose magnesium faster than you can replace it from your diet. These situations include treatment with “water pills” (diuretics such as furosemide, hydrochlorothiazide), a poor diet, alcoholism, or other medical conditions (such as severe diarrhea/vomiting, stomach/intestinal absorption problems, poorly controlled diabetes).

How to use Magnesium Oxide

Take this product by mouth as directed. Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

It is best to take magnesium supplements with a meal to reduce stomach upset and diarrhea unless otherwise directed by the product instructions or your doctor.

Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow extended-release capsules and delayed-release/enteric coated tablets or capsules whole. Do not crush or chew extended-release or delayed-release/enteric coated capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are taking the chewable tablets, chew each tablet thoroughly before swallowing.

If you are using a liquid product, use a medication measuring device to carefully measure the dose. Do not use a household spoon because you may not get the correct dose. If you are using a suspension, shake the bottle well before each dose.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time(s) each day. Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed on the product package or by your doctor. Too much magnesium in the blood can cause serious side effects.

Tell your doctor if symptoms of low magnesium blood levels (such as muscle cramps, tiredness, irritability, depression) last or get worse. If you think you may have a serious medical problem, get medical help right away.

Side Effects

Stomach upset and diarrhea may occur. Taking this product with a meal helps to reduce these effects. If either of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking a magnesium supplement, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have the following health problem, consult your doctor or pharmacist before using this product: kidney disease.

Liquids, powders, or some other forms of this product may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

During pregnancy, this product should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this product passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: cellulose sodium phosphate, digoxin, sodium polystyrene sulfonate.

Magnesium can bind with certain medications, preventing their full absorption. If you are taking a tetracycline-type medication (such as demeclocycline, doxycycline, minocycline, tetracycline), separate the time of the dose from the time of the magnesium supplement dose by at least 2 to 3 hours. If you are taking a bisphosphonate (for example, alendronate), a thyroid medication (for example, levothyroxine), or a quinolone-type antibiotic (such as ciprofloxacin, levofloxacin), ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Check the labels on all your prescription and nonprescription/herbal products (such as antacids, laxatives, vitamins) because they may contain magnesium. Ask your pharmacist about using those products safely.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include slow heartbeat, severe drowsiness, dizziness, confusion, muscle weakness, loss of consciousness.

Lab and/or medical tests (such as magnesium blood levels, kidney function) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Magnesium supplements are available in different forms with different amounts of magnesium. Many are available without a prescription. Ask your doctor or pharmacist for help in selecting the best product for you.

Eat a well-balanced diet. Foods high in magnesium include avocados, bananas, beans, whole grain cereals, green vegetables, and nuts.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: R 339

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: GP400

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: MgO

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 240 mg (as magnesium oxide) oral powder packet

Color: whiteShape: Imprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: T

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: logo and 174

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 500 mg capsule

Color: clearShape: oblongImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: whiteShape: ovalImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 420 mg tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 500 mg tablet

Color: whiteShape: oblongImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 400 mg (as magnesium oxide) tablet

Color: whiteShape: oblongImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: logo and 174

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 400 mg (as magnesium oxide) capsule

Color: dark brownShape: oblongImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: tanShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: T

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: whiteShape: roundImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium 250 mg (as magnesium oxide) tablet

Color: whiteShape: oblongImprint:

This medicine is a white, round, scored, tablet imprinted with “R 339”.

magnesium oxide 400 mg (241.3 mg magnesium) tablet

Color: whiteShape: roundImprint: logo and 174

This medicine is a white, round, scored, tablet imprinted with “R 339”.

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Drug Survey

Are you currently using Magnesium Oxide?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Magnesium Oxide (Mag-Ox 400) – Side Effects, Interactions, Uses, Dosage, Warnings

uses

What is Magnesium Oxide (Mag-Ox 400) used for?

  • Dyspepsia
  • Constipation
  • Vitamin/Mineral Supplementation during Pregnancy/Lactation

warnings

What is the most important information I should know about Magnesium Oxide (Mag-Ox 400)?

You should not use magnesium oxide if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially:

  • kidney disease;
  • heart disease;
  • nausea, vomiting;
  • a blockage in your intestines;
  • low levels of calcium in your blood; or
  • a sudden change in bowel habits for 2 weeks or longer.

It is not known whether magnesium oxide will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.

It is not known whether magnesium oxide passes into breast milk or if it could affect a nursing baby. Ask a doctor before using this medicine if you are breast-feeding.

Do not give this medicine to a child without medical advice.

Magnesium oxide should not be given to a child younger than 6 years old.

Side Effects

What are the side effects of Magnesium Oxide (Mag-Ox 400)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using magnesium oxide and call your doctor at once if you have:

  • rectal bleeding;
  • coughing up blood or vomit that looks like coffee grounds;
  • bloody or tarry stools; or
  • no bowel movement after using magnesium oxide as a laxative.

Common side effects may include:

  • diarrhea; or
  • upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Magnesium Oxide (Mag-Ox 400) if I’m pregnant or breastfeeding?

C

Risk cannot be ruled out

Based on FDA pregnancy categories

It is not known whether magnesium oxide will harm an unborn baby. Ask a doctor before using this medicine if you are pregnant.

It is not known whether magnesium oxide passes into breast milk or if it could affect a nursing baby. Ask a doctor before using this medicine if you are breast-feeding.

Interactions

What drugs and food should I avoid while taking Magnesium Oxide (Mag-Ox 400)?

Magnesium oxide can make it harder for your body to absorb other medicines you take by mouth. Avoid taking other medicines within 2 hours before or 2 hours after you take magnesium oxide. You may need to wait 4 hours to take your other medicines after taking magnesium oxide. Ask your doctor how to best schedule your medications.

Dosage Guidelines & Tips

How to take Magnesium Oxide (Mag-Ox 400)?

Use Magnesium Oxide (Mag-Ox 400) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Magnesium Oxide (Mag-Ox 400)?

Since magnesium oxide is sometimes used when needed, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Overdose Signs

What happens if I overdose on Magnesium Oxide (Mag-Ox 400)?

Overdose symptoms may include nausea, vomiting, weakness, breathing problems, slow reflexes, weak pulse, extreme drowsiness, and feeling dizzy or light-headed.

If you think you or someone else may have overdosed on: Magnesium Oxide (Mag-Ox 400),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Magnesium Oxide (Mag-Ox 400), call 911

911

What to Expect

Some studies suggest that magnesium oxide is poorly absorbed by the digestive tract.

The best way to get enough magnesium is to eat a well-balanced diet. Good sources of magnesium include green leafy vegetables, legumes, nuts, seeds, and whole grains.

Stop taking magnesium and let your physician know if you experience any unusual side effects.

Secondary Uses

Though its effectiveness isn’t conclusively proven, magnesium oxide is generally safe and well tolerated and is sometimes taken to help treat other conditions, such as migraines or depression.

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Description of MAGNESIUM OXIDE indications, dosages, contraindications of the active substance MAGNESIUM OXIDE

BP
British Pharmacopoeia


drug interaction

Included in preparations:
list

Pharmacological action

Antacid. Magnesium oxide, turning into magnesium hydroxide when interacting with water, neutralizes free hydrochloric (hydrochloric) acid in the stomach, reduces the peptic activity of gastric juice. When taken on an empty stomach, the antacid effect is short-lived (about 30 minutes), when taken after meals, its duration increases to 3-4 hours.

Magnesium chloride, formed in the stomach, has a laxative effect in the intestines. By increasing the osmotic pressure in the intestinal lumen, it increases peristalsis.

There is evidence that magnesium oxide in combination with pyridoxine reduces the formation of calcium oxalate and prevents the development of oxalate nephrourolithiasis.

Indications of the active substance
MAGNESIUM OXIDE

Gastritis (acute, exacerbation of chronic with increased and normal secretion), duodenitis (acute, exacerbation of chronic), exacerbation of peptic ulcer of the stomach and duodenum, gastralgia, dyspeptic symptoms in peptic ulcer of the stomach and duodenum (after taking medications, with diet errors, drinking ethanol, nicotine, coffee), reflux esophagitis, pan creatitis, constipation; acid poisoning; oxalate nephrourolithiasis (prevention).

Open list of ICD-10 codes

K21.0 Gastroesophageal reflux with esophagitis
K25 Gastric ulcer
K26 Duodenal ulcer
K27 Peptic ulcer
K29 Gastritis and duodenitis
K30 Functional dyspepsia (digestive disorders)
K59.0 Constipation
K86.1 Other chronic pancreatitis
N20 Kidney and ureter stones
N21 Lower urinary tract stones
R10. 1 Pain localized in the upper abdomen
R12 Heartburn
T54.2 Corrosive acids and acid-like substances

Dosage regimen

For oral administration, a single dose is 0.25-2.5 g. The frequency and duration of use depend on the indications.

Side effects

Possible: diarrhea, allergic reactions.

Contraindications for use

Hypersensitivity to magnesium oxide; hypermagnesemia, children’s age (depending on the dosage form).

Use in impaired renal function

Use with caution in renal insufficiency.

In patients with impaired renal function, the use of magnesium oxide may develop hypermagnesemia.

Use in children

May be used in children according to indications, in doses and dosage forms recommended according to age. It is necessary to strictly follow the instructions in the instructions for magnesium oxide preparations on contraindications for use in children of different ages of specific dosage forms of magnesium oxide.

Special instructions

Use with caution in renal failure.

In patients with impaired renal function, the use of magnesium oxide may develop hypermagnesemia.

Usually used in combination with aluminum containing antacids to reduce gastrointestinal side effects and increase duration of action.

Magnesium oxide can be used in cases of magnesium deficiency in the body, and also as a dietary supplement.

Drug interactions

When used simultaneously with antacids containing aluminum, side effects from the gastrointestinal tract are reduced and the duration of action of antacids is increased.

With simultaneous use with indomethacin, a decrease in the concentration of indomethacin in the blood plasma, a decrease in the irritating effect of indomethacin on the gastrointestinal tract, is possible.

With simultaneous use with nitrofurantoin, a decrease in the absorption of nitrofurantoin is possible; with tetracyclines, iron salts – the absorption of tetracyclines, iron salts decreases.

Active substance MAGNESIUM OXIDE* (MAGNESII OXYDUM*)

  • Pharmacological properties
  • Indications MAGNESIUM OXIDE*
  • Application of MAGNESIUM OXIDE*
  • Contraindications
  • Side effects
  • Interactions
  • Diagnosis
  • Recommended alternatives
  • Trade names

Medicines containing the active substance MAGNESIUM OXIDE*

Prices in pharmacies

Prices in pharmacies

Prices in pharmacies

Magnesium oxide powder is practically not absorbed in the intestine, so it is used mainly as an antacid. Neutralizes hydrochloric acid with the formation of magnesium chloride without the release of carbon dioxide and secondary hypersecretion. Entering the intestines, magnesium chloride has a slight laxative effect.

When using magnesium oxide in the form of effervescent tablets, the bioavailability of magnesium is increased. Magnesium is a vital trace element; takes part in the activation of more than 300 enzymes that regulate metabolic processes (see Magnesium lactate). The daily requirement for magnesium is 300 mg. An unbalanced diet, intense physical activity, including sports, alcohol abuse contribute to the development of magnesium deficiency in the body, which is manifested by a decrease in nonspecific resistance, working capacity, and a deterioration in general well-being.

magnesium oxide powder – hyperacid gastritis, peptic ulcer of the stomach and duodenum, acid poisoning;

effervescent soluble tablets – magnesium deficiency, accompanied by neuromuscular disorders, calf muscle cramps.