What are the key uses of methylcobalamin. How should methylcobalamin be taken for optimal absorption. What are the common side effects of methylcobalamin. What precautions should be taken when using methylcobalamin. How to properly store methylcobalamin.

Understanding Methylcobalamin: The Active Form of Vitamin B12

Methylcobalamin is the activated form of Vitamin B12, an essential nutrient for maintaining proper brain function, nerve health, and red blood cell production. This powerful compound plays a crucial role in the formation of myelin, a protective sheath covering nerve fibers. Without adequate methylcobalamin, the myelin sheath may not develop properly or maintain its integrity, potentially leading to various neurological issues.

Key Uses and Benefits of Methylcobalamin

Methylcobalamin offers a range of therapeutic benefits, particularly for individuals suffering from Vitamin B12 deficiency. Here are some of its primary uses:

• Treating nerve problems and anemia by restoring Vitamin B12 levels
• Regenerating and improving damaged nerves caused by conditions like pernicious anemia, neuropathy, and neuralgia
• Alleviating back pain and addressing nervous system issues related to Vitamin B12 deficiency
• Acting as a painkiller for individuals with diabetes

How does methylcobalamin help in nerve regeneration?

Methylcobalamin promotes nerve regeneration by stimulating the synthesis of myelin, the protective covering around nerve fibers. This process helps repair damaged nerves and improve their functionality, potentially reducing pain and other neurological symptoms associated with various conditions.

Proper Administration of Methylcobalamin

To maximize the benefits of methylcobalamin, it’s essential to follow the correct administration guidelines:

• Oral tablets should be taken on an empty stomach, preferably in the morning, 30 minutes before eating or 2 hours after a meal
• Avoid swallowing or chewing the entire tablet or lozenge
• Injections are typically administered into a muscle 1 to 3 times per week, as directed by a healthcare professional
• Never alter the dosage without consulting your doctor

Why is it recommended to take methylcobalamin on an empty stomach?

Methylcobalamin is a water-soluble vitamin, and taking it on an empty stomach enhances its absorption in the body. This timing allows for optimal uptake of the vitamin without interference from other foods or substances that may be present in the digestive system.

Recognizing and Managing Side Effects

While methylcobalamin is generally well-tolerated, some individuals may experience side effects. It’s crucial to be aware of potential adverse reactions and seek medical attention if necessary.

What are the most common side effects of methylcobalamin?

The most frequently reported side effects of methylcobalamin include:

• Vomiting
• Diarrhea
• Nausea
• Headache
• Loss of appetite

If you experience persistent side effects or signs of an allergic reaction (such as difficulty breathing, hives, or swelling of the face, lips, tongue, or throat), discontinue use and seek immediate medical assistance.

Essential Precautions for Methylcobalamin Use

To ensure safe and effective use of methylcobalamin, consider the following precautions:

• Limit alcohol consumption, as it can interfere with methylcobalamin absorption
• Avoid using expired tablets
• Do not administer methylcobalamin to children without proper medical guidance
• Inform your healthcare provider about any allergies, especially to vitamin B12 or cobalt
• Disclose all current medications, including vitamins, herbal supplements, and over-the-counter drugs
• Notify your doctor if you have a history of Leber’s disease, folic acid or iron deficiency, or low potassium levels
• Discuss methylcobalamin use if you are pregnant, breastfeeding, or planning to conceive

How does alcohol consumption affect methylcobalamin absorption?

Alcohol can interfere with the body’s ability to absorb methylcobalamin effectively. Excessive alcohol intake may reduce the absorption and utilization of this vital nutrient, potentially diminishing its therapeutic benefits. It’s advisable to limit alcohol consumption while taking methylcobalamin supplements to ensure optimal results.

Proper Storage and Handling of Methylcobalamin

To maintain the efficacy of methylcobalamin, proper storage is essential:

• Store in a cool, dry place at room temperature (20°C to 25°C)
• Protect from direct light, heat, and air exposure
• Keep out of reach of children

What happens if methylcobalamin is not stored properly?

Improper storage of methylcobalamin can lead to degradation of the vitamin, potentially reducing its potency and effectiveness. Exposure to heat, light, or moisture may cause the supplement to break down, resulting in a less potent product that may not provide the intended therapeutic benefits.

Managing Missed Doses and Potential Overdose

In the event of a missed dose or accidental overdose, follow these guidelines:

What should I do if I miss a dose of methylcobalamin?

If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Never double up on doses to compensate for a missed one, as this may increase the risk of side effects.

How should I respond to a methylcobalamin overdose?

In case of an overdose, seek immediate medical attention at the nearest emergency department. Bring the medication container or packaging with you for reference. While methylcobalamin is generally considered safe, an overdose may lead to adverse effects that require professional medical intervention.

Interactions with Other Medications and Substances

Methylcobalamin may interact with various medications and substances, potentially affecting its efficacy or causing unwanted side effects. It’s crucial to inform your healthcare provider about all medications you’re taking, including:

• Chloramphenicol
• Colchicine
• Antibiotics
• Oral diabetes medications containing metformin
• Stomach acid reducers
• Over-the-counter medications
• Ayurvedic or herbal supplements

How do these medications interact with methylcobalamin?

Different medications can interact with methylcobalamin in various ways. For example, chloramphenicol may interfere with the red blood cell response to methylcobalamin therapy. Metformin can reduce vitamin B12 absorption, potentially necessitating higher doses of methylcobalamin. Stomach acid reducers may also impair vitamin B12 absorption. Your healthcare provider can assess potential interactions and adjust your treatment plan accordingly.

Long-term Benefits and Considerations of Methylcobalamin Therapy

While methylcobalamin offers numerous benefits, it’s important to consider the long-term aspects of this therapy:

What are the potential long-term benefits of methylcobalamin supplementation?

Long-term methylcobalamin supplementation may provide several benefits, including:

• Improved nerve function and reduced neuropathic pain
• Enhanced cognitive function and mental clarity
• Better energy levels and reduced fatigue
• Improved mood and emotional well-being
• Healthier skin, hair, and nails

However, it’s crucial to maintain regular check-ups with your healthcare provider to monitor your vitamin B12 levels and adjust the treatment as needed.

Are there any risks associated with long-term methylcobalamin use?

While methylcobalamin is generally considered safe for long-term use, some considerations include:

• Potential masking of underlying conditions, such as pernicious anemia
• Risk of overcompensation, leading to excessively high vitamin B12 levels
• Possible interactions with other medications or supplements over time

Regular monitoring and communication with your healthcare provider can help mitigate these risks and ensure optimal long-term benefits from methylcobalamin therapy.

Methylcobalamin vs. Other Forms of Vitamin B12

Methylcobalamin is one of several forms of vitamin B12 available for supplementation. Understanding the differences between these forms can help in choosing the most appropriate option for individual needs.

How does methylcobalamin compare to cyanocobalamin?

Methylcobalamin and cyanocobalamin are two common forms of vitamin B12 supplements:

• Methylcobalamin is the active form of B12, readily usable by the body
• Cyanocobalamin is a synthetic form that requires conversion to methylcobalamin in the body
• Methylcobalamin may be more bioavailable and effective for some individuals
• Cyanocobalamin is often less expensive and has a longer shelf life

The choice between these forms depends on individual health needs, absorption capabilities, and healthcare provider recommendations.

Dietary Sources of Vitamin B12 and Supplementation

While methylcobalamin supplements can effectively address vitamin B12 deficiency, it’s also important to consider dietary sources of this essential nutrient.

What are the best food sources of vitamin B12?

Natural dietary sources of vitamin B12 include:

• Animal products: beef, liver, fish, poultry, eggs, and dairy
• Fortified foods: some breakfast cereals, plant-based milk alternatives, and nutritional yeasts

For individuals following vegetarian or vegan diets, supplementation with methylcobalamin may be necessary to maintain adequate B12 levels.

Can dietary sources replace the need for methylcobalamin supplements?

For most people with a balanced diet, dietary sources can provide sufficient vitamin B12. However, certain groups may require supplementation:

• Older adults with reduced absorption capacity
• Individuals with gastrointestinal disorders affecting nutrient absorption
• Vegans and some vegetarians
• People with pernicious anemia or other conditions affecting B12 absorption

Consult with a healthcare provider to determine if dietary sources are sufficient or if methylcobalamin supplementation is necessary.

Methylcobalamin and Cognitive Health

The role of methylcobalamin in cognitive function and neurological health is an area of growing interest and research.

How does methylcobalamin contribute to cognitive health?

Methylcobalamin supports cognitive health through several mechanisms:

• Promoting the formation and maintenance of myelin, essential for nerve signal transmission
• Supporting the synthesis of neurotransmitters involved in mood regulation and cognitive function
• Reducing homocysteine levels, which may contribute to cognitive decline when elevated
• Enhancing energy production in brain cells

These effects may contribute to improved memory, concentration, and overall cognitive performance, particularly in individuals with vitamin B12 deficiency.

Can methylcobalamin supplementation prevent or treat cognitive decline?

While research is ongoing, some studies suggest that methylcobalamin supplementation may have potential benefits for cognitive health:

• May help slow cognitive decline in older adults with vitamin B12 deficiency
• Could potentially reduce the risk of dementia and Alzheimer’s disease, though more research is needed
• May improve cognitive function in individuals with neurological disorders

However, it’s important to note that methylcobalamin is not a cure for cognitive disorders, and its effects may vary among individuals. Always consult with a healthcare provider before using methylcobalamin for cognitive health purposes.

Methylcobalamin in Sports and Athletic Performance

The potential benefits of methylcobalamin for athletes and fitness enthusiasts have garnered attention in recent years.

How can methylcobalamin impact athletic performance?

Methylcobalamin may contribute to athletic performance in several ways:

• Enhancing energy production and reducing fatigue
• Supporting red blood cell formation, potentially improving oxygen delivery to muscles
• Aiding in muscle recovery and repair
• Potentially reducing exercise-induced oxidative stress

These effects may be particularly beneficial for endurance athletes or those engaged in intense training regimens.

Is methylcobalamin considered a performance-enhancing substance in sports?

Methylcobalamin is not typically classified as a performance-enhancing substance in sports:

• It is a natural vitamin and not banned by major sports organizations
• Supplementation is generally considered safe and legal for athletes
• However, athletes should always check with their specific sporting bodies regarding supplement regulations

While methylcobalamin may support overall health and potentially enhance performance, it is not a substitute for proper training, nutrition, and recovery practices.

Future Directions in Methylcobalamin Research

As scientific understanding of methylcobalamin continues to evolve, several areas of research hold promise for future applications and insights.

What are some emerging areas of methylcobalamin research?

Ongoing and future research on methylcobalamin may focus on:

• Its potential role in preventing and treating neurodegenerative diseases
• Exploring new delivery methods for improved absorption and efficacy
• Investigating its effects on gut health and the microbiome
• Studying its potential in combination with other nutrients for synergistic effects
• Examining its impact on epigenetic processes and gene expression

These research directions may lead to new therapeutic applications and a deeper understanding of methylcobalamin’s role in human health.

How might future findings impact the use of methylcobalamin in healthcare?

Future research findings could potentially:

• Expand the range of conditions for which methylcobalamin is prescribed
• Lead to more targeted and personalized supplementation strategies
• Improve diagnostic tools for identifying vitamin B12 deficiency and related disorders
• Inform public health policies regarding fortification and supplementation recommendations

As our knowledge of methylcobalamin grows, healthcare practices may evolve to more effectively leverage its benefits for various aspects of health and well-being.

Methylcobalamin : Uses, Side Effects, Dosage, Precautions & More

Methylcobalamin

Methylcobalamin is the activated form of Vitamin B12, available as an oral medicine. It is prescribed for people suffering from a deficiency of vitamin B12. The aim of this vitamin is to help with the proper functioning of the brain and nerves as well as the production of red blood cells.

Methylcobalamin helps treat the deficiency of vitamin B12 by producing a substance known as “myelin”. This substance is responsible for covering nerve fibres and protecting them. Without inadequate amounts of methylcobalamin in the body, the myelin sheath cannot develop well or stay healthy.

What are the uses of Methylcobalamin?

Some of the uses of methylcobalamin are

• Methylcobalamin is prescribed for treating certain nerve problems and anaemia by restoring the levels of vitamin B12 in the body.

• Replenishment of the vitamin helps in the regeneration and improvement of damaged and irritated nerves, which can be caused by medical conditions like pernicious anaemia, neuropathy, and neuralgia.

• It is also prescribed for people who experience back pain, anaemia, or other problems related to the nervous system that can be caused by a deficiency of vitamin B12.

• Methylcobalamin also works as a painkiller for people with diabetes.

How and when to take Methylcobalamin?

Methylcobalamin is available as tablets and injections as well. The tablets are to be consumed orally. Do not try to swallow or chew an entire tablet or lozenge. 

• Methylcobalamin is a water-soluble vitamin. It is better absorbed in the body when taken on an empty stomach. So, you can take one in the morning, at least 30 minutes before eating, or 2 hours after you have eaten.

• Methylcobalamin injections are injected into a muscle. The administration is usually done 1 to 3 times a week. Follow the instructions given by your doctor. 

• Do not increase or decrease the dose without consulting your doctor.

What are the side effects of Methylcobalamin?

Get immediate medical assistance in case you notice signs of an allergic reaction like difficulty in breathing, hives (itchy red bumps on the skin), or swollen lips, face, tongue, or throat. Certain common side effects of Methylcobalamin include:

• Vomiting

• Diarrhoea

• Nausea

• Headache

• Loss of appetite

If you face any of the mentioned (or other) side effects for a persistent period, stop taking the medicine and contact your doctor for help immediately.  

What precautions are to be taken while using Methylcobalamin?

Certain precautions must be taken before any medicines are prescribed or taken by a person. In the case of methylcobalamin

• Avoid drinking alcohol in large amounts since it makes it difficult for your body to absorb methylcobalamin.

• Do not buy or consume expired tablets.

• Do not give methylcobalamin to a child without proper medical advice.

Other than the precautions mentioned above, make sure to mention the following details to your doctor before taking Methylcobalamin:

• If you are allergic to vitamin B12 or cobalt

• If you are taking any other vitamins

• If you have or used to suffer from Leber’s disease, folic acid or iron deficiency, or low levels of potassium in the blood

• If you are pregnant, breastfeeding, or trying for a baby

• If you are taking any other medicines, especially chloramphenicol, colchicine, antibiotic medicines, oral diabetes medicines containing metformin, medicines that reduce stomach acid, or medicines that do not require a prescription, like Ayurvedic or herbal.

What if I miss a dose of Methylcobalamin?

There is no need to worry if you miss a dose. Take the dose as soon as you remember, but leave out the missed dose if it is almost time for your next dose. Do not try to take two doses together to make up for the missed dose as it might lead to side effects.

What if you overdose on Methylcobalamin?

If you or someone you know overdoses on Methylcobalamin, immediately go to the emergency department of the nearest hospital. Take the container or sachet of the medicine with you for reference.

What are the storage conditions for Methylcobalamin?

• Store methylcobalamin in a dry and cool place, preferably at room temperature between 20°C and 25°C.

• Keep it away from direct contact with light, heat, and air.

• Keep it safely in a place that is away from children’s reach.

Can I take Methylcobalamin with other medications?

Unless prescribed by your medical practitioner or pharmacist, do not consume methylcobalamin with any other medicine. If it is prescribed to be taken with some other medicine, do not go beyond the prescribed dosage for either of the medicines.

How quickly will the Methylcobalamin tablet show results?

Typically, results can be observed within 48 to 72 hours after taking Methylcobalamin.

Comparison of Methylcobalamin with Vitamin B complex

Conclusion

It is wise to always follow the instructions provided by your doctor when consuming any medications. Keep all the medications out of reach and sight of children to avoid any mishaps.

References:

https://www.drugs.com/mtm/methylcobalamin-vitamin-b12.html https://www.practo.com/medicine-info/methylcobalamin-179-api

Disclaimer: The information provided here is not meant to substitute an advice from a healthcare professional. The information is not intended to cover all the possible uses, side-effects, precautions, and drug interactions. This information is not intended to suggest that using a specific drug is suitable, safe, or efficient for you or anyone else. The absence of any information or warning regarding the drug should not be interpreted as an implicit guarantee from the organisation. We strongly advise you to consult a doctor if you have any concerns about the drug and never use the medication without a doctor’s prescription.

Methylcobalamin (Vitamin B12 Methylcobalamin) – Side Effects, Interactions, Uses, Dosage, Warnings

Reviewed: October 8, 2020

Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Methylcobalamin may also be used for purposes not listed in this medication guide.

warnings

What is the most important information I should know about Methylcobalamin (Vitamin B12 Methylcobalamin)?

You should not use methylcobalamin if you are allergic to vitamin B12 or cobalt.

Tell your doctor if you have ever had:

• Leber’s disease or other form of optic nerve damage;
• an iron or folic acid deficiency; or
• low levels of potassium in your blood.

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

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Side Effects

What are the side effects of Methylcobalamin (Vitamin B12 Methylcobalamin)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

• nausea, vomiting, diarrhea;
• loss of appetite; or
• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Methylcobalamin (Vitamin B12 Methylcobalamin) if I’m pregnant or breastfeeding?

Tell your doctor if you are pregnant or breastfeeding.

Interactions

What drugs and food should I avoid while taking Methylcobalamin (Vitamin B12 Methylcobalamin)?

Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb methylcobalamin.

Dosage Guidelines & Tips

How to take Methylcobalamin (Vitamin B12 Methylcobalamin)?

Use Methylcobalamin (Vitamin B12 Methylcobalamin) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Methylcobalamin (Vitamin B12 Methylcobalamin)?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Methylcobalamin (Vitamin B12 Methylcobalamin)?

If you think you or someone else may have overdosed on: Methylcobalamin (Vitamin B12 Methylcobalamin),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Methylcobalamin (Vitamin B12 Methylcobalamin), call 911

911

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Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health. 

Mecobalamin – instructions for use

Mecobalamin

Instruction:

• Pharmacological action
• Readings
• Contraindications
• Pregnancy and breastfeeding
• Dosage and administration
• Side effects
• Interaction
• Precautions
• Classification

Pharmacological action

Mecobalamin – coenzyme form of vitamin B ₁₂ . Participates in the processes of transmethylation, in the synthesis of proteins and nucleic acids, in the metabolism of carbohydrates and lipids. Stimulates the monooxygenase system, has a protective effect on SH-groups and activates liver glutathione transferases. It has an anabolic effect (increasing physical performance), a regenerating effect in case of mechanical and toxic damage to the nerve trunks. In diseases of the peripheral nervous system, it reduces pain, helps to restore motor functions and reduce autonomic disorders. Having a hepatoprotective effect, it has a beneficial effect on liver function in toxic hepatitis, cirrhosis of the liver, and pancreatitis. Reduces joint damage in adjuvant arthritis, has a hematopoietic effect.

Indications

Diseases of the peripheral nervous system (complex treatment): neuralgia, polyneuropathy, radiculopathy. Chronic hepatitis, fatty degeneration of the liver, cirrhosis of the liver, chronic pancreatitis. The need to improve physical performance (including in sports).

Contraindications

Hypersensitivity.

Pregnancy and breastfeeding

Not recommended during pregnancy and breastfeeding.

Method of administration and doses

Inside, in diseases of the peripheral nervous system – 10 mg 1 time per day. In the complex therapy of liver diseases and pancreatitis – 5 mg 2 times a day or 10 mg 1 time per day. The course of treatment is 3-4 weeks. If necessary, after 1 month, repeat courses of treatment are carried out. In sports medicine – 5-10 mg once a day for 2-3 weeks.

Side effects

Allergic reactions.

Interaction

The drug is pharmaceutically incompatible with ascorbic acid, heavy metal salts (inactivation), thiamine bromide, pyridoxine, riboflavin (because the cobalt ion contained in the drug molecule destroys other vitamins).

Aminoglycosides, salicylates, antiepileptics, colchicine, preparations K ⁺ reduce absorption.

Intake enhances the development of allergic reactions caused by thiamine.

Chloramphenicol reduces the hematopoietic response.

Do not combine with drugs that increase blood clotting.

Risk of developing allergic reactions in the presence of thiamine.

Precautions

Vitamin B deficiency ₁₂ must be confirmed diagnostically before prescribing the drug, as it may mask folic acid deficiency.

During treatment, it is necessary to monitor peripheral blood parameters: on the 5th–8th day of treatment, the number of reticulocytes and iron concentration are determined.

Classification

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Read more about the active substance Mecobalamin:

• INN
• Reviews
• Questions
• Latin name
• Chemical formula

Information about the active substance Mecobalamin is intended for medical and pharmaceutical professionals, for reference purposes only. The instructions are not intended to replace professional medical advice, diagnosis or treatment. The information contained here may change over time. The most accurate information on the use of drugs containing the active substance Mecobalamin is contained in the manufacturer’s instructions attached to the package.

Active substance MECOBALAMINUM | Compendium – drug reference book

• Pharmacological properties
• Indications MECOBALAMIN
• Application of MECOBALAMIN
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Diagnosis
• Recommended alternatives
• Trade names

Medicinal preparations containing the active substance MECOBALAMIN

Diacobal

film-coated tablets 500 mcg blister, № 30

Kusum

Prices in pharmacies

9 0002 Neurocobal ^®

film-coated tablets 500 mcg blister, № 90

Gledpharm Ltd

Prices in pharmacies

mecobalamin is one of the active forms of vitamin B 9 0029 12 . Vitamin B ₁₂ is essential for nuclear protein and myelin synthesis, cell reproduction, normal growth and normal erythropoiesis. Compared to other forms of vitamin B ₁₂ mecobalamin at the subcellular level is better transported to neuronal organelles. It is due to this property that it is more effective in the treatment of diseases of the nervous system.

Mecobalamin is a coenzyme of methionine synthase, an enzyme involved in the conversion of homocysteine ​​to methionine in protein and DNA methylation reactions. It is known that methylcobalamin normalizes the axonal transport of protein complexes and promotes axonal regeneration. Mecobalamin also promotes myelination of neurons by stimulating the synthesis of phospholipids. In addition, methylcobalamin restores delayed synaptic transmission and reduces the content of neurotransmitters to normal levels.

The use of therapeutic doses of mecobalamin promotes detoxification processes in the nervous system due to an increase in the content of tetrahydrofolate. Mecobalamin also promotes the conversion of homocysteine ​​to S-adenosine methionine, which is a universal donor of methyl groups, which leads to the activation of transmethylation reactions.

peripheral neuropathy

is used by mouth in adults. The recommended daily dose is 1500 mcg, which is divided into 3 doses. The duration of the course of treatment depends on the nature and course of the disease and is determined individually. In the absence of a clinical effect after continuous use of the drug for 1 month, the drug should be discontinued.

hypersensitivity to mecobalamin or other components of the drug. Erythremia, erythrocytosis. Neoplasms, except in cases accompanied by megaloblastic anemia and vitamin B deficiency ₁₂ . Acute thromboembolic diseases. Angina pectoris of a high functional class.

from the gastrointestinal tract: anorexia, nausea, vomiting, diarrhea;

from the nervous system : irritability, headache, dizziness, migraine, severe anxiety disorders, agitation, insomnia;

from the side of the cardiovascular system: tachycardia, pain in the heart;

from the immune system: hypersensitivity reactions, including urticaria, anaphylactic shock, anaphylactoid reactions;

from the musculoskeletal system: muscle pain, joint pain;

on the skin side: itching, rash, acne;

from the blood and lymphatic system: thrombosis, hypercoagulability4

general disorders: increased sweating, malaise, fever.

the drug should be used with caution in patients with allergic manifestations, liver disease in history.

Long-term use of high doses of the drug is not recommended for patients whose professional activity is associated with mercury or compounds containing mercury.

Not recommended for use with clotting agents. During the treatment period, it is necessary to monitor peripheral blood counts. Regarding patients with a tendency to thrombosis and patients with angina during treatment, care must be taken and blood clotting should be monitored.

With a tendency to develop leukocytosis and erythrocytosis, the dose of the drug must be reduced or temporarily suspended treatment.

There are no data on the negative effect of the drug on the speed of psychomotor reactions.

Simultaneous use with folic acid improves the absorption and absorption of mecobalamin.

Do not co-administer other preparations containing vitamin B ₁₂ .

Chloramphenicol reduces the hematopoietic response of reticulocytes to mecobalamin.