What are the primary uses of Methylcobalamin. How should it be taken for optimal absorption. What are the common side effects to watch out for. What precautions should be considered before using Methylcobalamin. How to store Methylcobalamin properly.

Understanding Methylcobalamin: The Active Form of Vitamin B12

Methylcobalamin is the activated form of Vitamin B12, playing a crucial role in various bodily functions. This essential nutrient is vital for maintaining healthy brain function, nerve health, and red blood cell production. But what exactly makes methylcobalamin so important?

Methylcobalamin’s primary function is to produce a substance called “myelin,” which forms a protective sheath around nerve fibers. This myelin sheath is essential for proper nerve function and communication. Without adequate methylcobalamin, the body cannot produce or maintain this protective layer effectively, potentially leading to various neurological issues.

How does Methylcobalamin differ from other forms of Vitamin B12?

Unlike cyanocobalamin, which is a synthetic form of B12, methylcobalamin is a naturally occurring form that is more readily absorbed and utilized by the body. This increased bioavailability makes it a preferred choice for many healthcare professionals when treating Vitamin B12 deficiency.

Key Uses of Methylcobalamin in Medical Treatment

Methylcobalamin serves multiple purposes in medical treatment, addressing various health concerns related to Vitamin B12 deficiency. Let’s explore its primary applications:

• Treating Vitamin B12 deficiency and its associated symptoms
• Addressing nerve problems and certain types of anemia
• Regenerating and improving damaged or irritated nerves
• Managing back pain and nervous system disorders
• Providing pain relief for individuals with diabetes

One of the most significant benefits of methylcobalamin is its ability to replenish Vitamin B12 levels in the body. This replenishment is crucial for individuals suffering from conditions such as pernicious anemia, neuropathy, and neuralgia. By restoring adequate B12 levels, methylcobalamin can help alleviate symptoms and improve overall health.

Can Methylcobalamin help with diabetic neuropathy?

Yes, methylcobalamin has shown promise in managing diabetic neuropathy. Its neuroprotective properties can help reduce pain and improve nerve function in diabetic patients experiencing neuropathic symptoms. However, it’s essential to consult with a healthcare provider before starting any new treatment regimen.

Proper Administration: How and When to Take Methylcobalamin

To maximize the benefits of methylcobalamin, it’s crucial to understand the proper administration methods and timing. Here are some key points to remember:

1. Methylcobalamin is available in both tablet and injectable forms.
2. Tablets should be taken orally, without chewing or swallowing whole.
3. For optimal absorption, take methylcobalamin on an empty stomach.
4. Morning administration, 30 minutes before eating or 2 hours after a meal, is often recommended.
5. Injectable methylcobalamin is typically administered into a muscle 1-3 times per week.

It’s important to note that while methylcobalamin is water-soluble, its absorption can be enhanced when taken on an empty stomach. This allows for better uptake by the body, maximizing its effectiveness.

What’s the recommended dosage for Methylcobalamin?

The appropriate dosage of methylcobalamin can vary depending on individual needs and the specific condition being treated. It’s crucial to follow your healthcare provider’s instructions carefully and avoid adjusting the dose without professional guidance. Typical dosages may range from 500 mcg to 5000 mcg per day, but this can differ based on the severity of the deficiency and other factors.

Identifying and Managing Methylcobalamin Side Effects

While methylcobalamin is generally well-tolerated, some individuals may experience side effects. It’s essential to be aware of potential adverse reactions and know when to seek medical attention.

What are the most common side effects of Methylcobalamin?

Common side effects of methylcobalamin include:

• Nausea
• Vomiting
• Diarrhea
• Headache
• Loss of appetite

While these side effects are generally mild, persistent or severe symptoms should be reported to a healthcare provider. In rare cases, more serious reactions may occur.

How to recognize signs of an allergic reaction to Methylcobalamin?

Although rare, allergic reactions to methylcobalamin can occur. Signs of an allergic reaction may include:

• Difficulty breathing
• Hives or itchy red bumps on the skin
• Swelling of the face, lips, tongue, or throat

If you experience any of these symptoms, seek immediate medical attention. Prompt treatment is crucial in managing allergic reactions effectively.

Essential Precautions for Safe Methylcobalamin Use

To ensure safe and effective use of methylcobalamin, certain precautions should be observed. These guidelines help minimize risks and optimize treatment outcomes.

What should be avoided while taking Methylcobalamin?

When using methylcobalamin, it’s important to:

• Limit alcohol consumption, as it can interfere with methylcobalamin absorption
• Avoid using expired tablets
• Refrain from administering methylcobalamin to children without proper medical advice

What medical conditions or medications may interact with Methylcobalamin?

Before starting methylcobalamin treatment, inform your healthcare provider if you:

• Have a history of allergies to vitamin B12 or cobalt
• Are taking other vitamins or supplements
• Have or have had Leber’s disease, folic acid deficiency, iron deficiency, or low potassium levels
• Are pregnant, breastfeeding, or planning to become pregnant
• Are taking medications such as chloramphenicol, colchicine, metformin, stomach acid reducers, or certain antibiotics

Disclosing this information helps your healthcare provider determine the most appropriate treatment plan and minimize potential interactions or complications.

Managing Missed Doses and Potential Overdose Situations

Even with the best intentions, missed doses can occur. Understanding how to handle these situations is crucial for maintaining consistent treatment.

What should you do if you miss a dose of Methylcobalamin?

If you miss a dose of methylcobalamin, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It’s important not to double up on doses to make up for a missed one, as this could increase the risk of side effects.

How to respond to a potential Methylcobalamin overdose?

In the event of a suspected overdose, immediate action is necessary:

1. Seek emergency medical attention immediately
2. Bring the medication container or packaging with you to the hospital
3. Provide medical staff with as much information as possible about the amount taken and when

While vitamin B12 is generally considered safe even in large doses due to its water-soluble nature, it’s always better to err on the side of caution and seek professional medical advice in cases of suspected overdose.

Proper Storage and Handling of Methylcobalamin

Proper storage of methylcobalamin is essential for maintaining its effectiveness and ensuring safety. Following these guidelines can help preserve the quality of your medication:

• Store methylcobalamin in a cool, dry place at room temperature (20°C to 25°C)
• Protect the medication from direct light, heat, and air exposure
• Keep methylcobalamin out of reach of children

How long can Methylcobalamin be stored before it expires?

The shelf life of methylcobalamin can vary depending on the specific product and formulation. Generally, most methylcobalamin supplements have a shelf life of 2-3 years when stored properly. Always check the expiration date on the packaging and avoid using the medication past its expiration date.

Proper storage not only ensures the medication’s efficacy but also helps prevent accidental ingestion by children or pets. By following these guidelines, you can maintain the quality and safety of your methylcobalamin supply.

Methylcobalamin in Special Populations: Pregnancy and Pediatric Use

The use of methylcobalamin in special populations, such as pregnant women and children, requires careful consideration and professional medical guidance.

Is Methylcobalamin safe during pregnancy and breastfeeding?

While vitamin B12 is essential for fetal development and maternal health, the use of methylcobalamin supplements during pregnancy should be discussed with a healthcare provider. In general, methylcobalamin is considered safe during pregnancy when taken as directed, but individual circumstances may vary.

For breastfeeding mothers, adequate vitamin B12 intake is crucial for infant health. However, the appropriate dosage should be determined by a healthcare professional to ensure both mother and baby receive optimal nutrition without risking overdose.

Can children take Methylcobalamin supplements?

Methylcobalamin can be used in pediatric populations, but it’s crucial to consult with a pediatrician before administering any supplements to children. The dosage and form of methylcobalamin may need to be adjusted based on the child’s age, weight, and specific health needs.

In some cases, children with certain genetic conditions or dietary restrictions may require vitamin B12 supplementation. However, this should always be done under close medical supervision to ensure safety and efficacy.

Integrating Methylcobalamin into a Holistic Health Approach

While methylcobalamin supplementation can be beneficial for addressing vitamin B12 deficiency, it’s important to consider it as part of a broader health strategy.

How can dietary choices support Methylcobalamin absorption?

Incorporating B12-rich foods into your diet can complement methylcobalamin supplementation. Some excellent sources of vitamin B12 include:

• Beef liver and other organ meats
• Fish, particularly salmon and trout
• Eggs
• Dairy products
• Fortified cereals and plant-based milk alternatives

For individuals following vegetarian or vegan diets, careful planning and potential supplementation may be necessary to ensure adequate B12 intake.

What lifestyle factors can impact Methylcobalamin effectiveness?

Several lifestyle factors can influence the absorption and effectiveness of methylcobalamin:

1. Alcohol consumption: Excessive alcohol intake can interfere with B12 absorption
2. Smoking: Nicotine can reduce B12 levels in the body
3. Stress: Chronic stress may impact nutrient absorption and utilization
4. Exercise: Regular physical activity can support overall health and nutrient absorption

By addressing these lifestyle factors and working with healthcare providers, individuals can optimize their methylcobalamin treatment and overall health outcomes.

Future Perspectives: Ongoing Research and Potential Applications

The field of vitamin B12 research, particularly regarding methylcobalamin, continues to evolve. Ongoing studies are exploring new potential applications and benefits of this crucial nutrient.

What new areas of research are emerging for Methylcobalamin?

Current and future research areas for methylcobalamin include:

• Neuroprotective effects in neurodegenerative disorders
• Potential role in cognitive function and memory enhancement
• Impact on cardiovascular health and homocysteine levels
• Applications in sleep regulation and circadian rhythm disorders
• Possible benefits for skin health and wound healing

As research progresses, our understanding of methylcobalamin’s full potential continues to expand, potentially leading to new therapeutic applications and improved treatment protocols.

How might future developments impact Methylcobalamin use and administration?

Advancements in methylcobalamin research may lead to:

1. More targeted delivery methods for enhanced absorption
2. Personalized dosing strategies based on genetic profiles
3. Combination therapies with other nutrients for synergistic effects
4. Improved diagnostic tools for assessing vitamin B12 status and deficiency

These developments could revolutionize how we approach vitamin B12 supplementation and deficiency treatment, potentially improving outcomes for patients across various health conditions.

As we continue to uncover the full potential of methylcobalamin, it remains a vital component in addressing vitamin B12 deficiency and supporting overall health. By staying informed about proper usage, potential side effects, and ongoing research, individuals can make informed decisions about incorporating methylcobalamin into their health regimen under professional guidance.

Methylcobalamin : Uses, Side Effects, Dosage, Precautions & More

Methylcobalamin

Methylcobalamin is the activated form of Vitamin B12, available as an oral medicine. It is prescribed for people suffering from a deficiency of vitamin B12. The aim of this vitamin is to help with the proper functioning of the brain and nerves as well as the production of red blood cells.

Methylcobalamin helps treat the deficiency of vitamin B12 by producing a substance known as “myelin”. This substance is responsible for covering nerve fibres and protecting them. Without inadequate amounts of methylcobalamin in the body, the myelin sheath cannot develop well or stay healthy.

What are the uses of Methylcobalamin?

Some of the uses of methylcobalamin are

• Methylcobalamin is prescribed for treating certain nerve problems and anaemia by restoring the levels of vitamin B12 in the body.

• Replenishment of the vitamin helps in the regeneration and improvement of damaged and irritated nerves, which can be caused by medical conditions like pernicious anaemia, neuropathy, and neuralgia.

• It is also prescribed for people who experience back pain, anaemia, or other problems related to the nervous system that can be caused by a deficiency of vitamin B12.

• Methylcobalamin also works as a painkiller for people with diabetes.

How and when to take Methylcobalamin?

Methylcobalamin is available as tablets and injections as well. The tablets are to be consumed orally. Do not try to swallow or chew an entire tablet or lozenge. 

• Methylcobalamin is a water-soluble vitamin. It is better absorbed in the body when taken on an empty stomach. So, you can take one in the morning, at least 30 minutes before eating, or 2 hours after you have eaten.

• Methylcobalamin injections are injected into a muscle. The administration is usually done 1 to 3 times a week. Follow the instructions given by your doctor. 

• Do not increase or decrease the dose without consulting your doctor.

What are the side effects of Methylcobalamin?

Get immediate medical assistance in case you notice signs of an allergic reaction like difficulty in breathing, hives (itchy red bumps on the skin), or swollen lips, face, tongue, or throat. Certain common side effects of Methylcobalamin include:

• Vomiting

• Diarrhoea

• Nausea

• Headache

• Loss of appetite

If you face any of the mentioned (or other) side effects for a persistent period, stop taking the medicine and contact your doctor for help immediately.  

What precautions are to be taken while using Methylcobalamin?

Certain precautions must be taken before any medicines are prescribed or taken by a person. In the case of methylcobalamin

• Avoid drinking alcohol in large amounts since it makes it difficult for your body to absorb methylcobalamin.

• Do not buy or consume expired tablets.

• Do not give methylcobalamin to a child without proper medical advice.

Other than the precautions mentioned above, make sure to mention the following details to your doctor before taking Methylcobalamin:

• If you are allergic to vitamin B12 or cobalt

• If you are taking any other vitamins

• If you have or used to suffer from Leber’s disease, folic acid or iron deficiency, or low levels of potassium in the blood

• If you are pregnant, breastfeeding, or trying for a baby

• If you are taking any other medicines, especially chloramphenicol, colchicine, antibiotic medicines, oral diabetes medicines containing metformin, medicines that reduce stomach acid, or medicines that do not require a prescription, like Ayurvedic or herbal.

What if I miss a dose of Methylcobalamin?

There is no need to worry if you miss a dose. Take the dose as soon as you remember, but leave out the missed dose if it is almost time for your next dose. Do not try to take two doses together to make up for the missed dose as it might lead to side effects.

What if you overdose on Methylcobalamin?

If you or someone you know overdoses on Methylcobalamin, immediately go to the emergency department of the nearest hospital. Take the container or sachet of the medicine with you for reference.

What are the storage conditions for Methylcobalamin?

• Store methylcobalamin in a dry and cool place, preferably at room temperature between 20°C and 25°C.

• Keep it away from direct contact with light, heat, and air.

• Keep it safely in a place that is away from children’s reach.

Can I take Methylcobalamin with other medications?

Unless prescribed by your medical practitioner or pharmacist, do not consume methylcobalamin with any other medicine. If it is prescribed to be taken with some other medicine, do not go beyond the prescribed dosage for either of the medicines.

How quickly will the Methylcobalamin tablet show results?

Typically, results can be observed within 48 to 72 hours after taking Methylcobalamin.

Comparison of Methylcobalamin with Vitamin B complex

Conclusion

It is wise to always follow the instructions provided by your doctor when consuming any medications. Keep all the medications out of reach and sight of children to avoid any mishaps.

References:

https://www.drugs.com/mtm/methylcobalamin-vitamin-b12.html https://www.practo.com/medicine-info/methylcobalamin-179-api

Disclaimer: The information provided here is not meant to substitute an advice from a healthcare professional. The information is not intended to cover all the possible uses, side-effects, precautions, and drug interactions. This information is not intended to suggest that using a specific drug is suitable, safe, or efficient for you or anyone else. The absence of any information or warning regarding the drug should not be interpreted as an implicit guarantee from the organisation. We strongly advise you to consult a doctor if you have any concerns about the drug and never use the medication without a doctor’s prescription.

Methylcobalamin (Vitamin B12 Methylcobalamin) – Side Effects, Interactions, Uses, Dosage, Warnings

Reviewed: October 8, 2020

Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Methylcobalamin may also be used for purposes not listed in this medication guide.

warnings

What is the most important information I should know about Methylcobalamin (Vitamin B12 Methylcobalamin)?

You should not use methylcobalamin if you are allergic to vitamin B12 or cobalt.

Tell your doctor if you have ever had:

• Leber’s disease or other form of optic nerve damage;
• an iron or folic acid deficiency; or
• low levels of potassium in your blood.

Tell your doctor if you are pregnant or breastfeeding.

Do not give this medicine to a child without medical advice.

User Reviews & Rating

No ratings yet for Methylcobalamin (Vitamin B12 Methylcobalamin)

Leave a Review

Side Effects

What are the side effects of Methylcobalamin (Vitamin B12 Methylcobalamin)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

• nausea, vomiting, diarrhea;
• loss of appetite; or
• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Methylcobalamin (Vitamin B12 Methylcobalamin) if I’m pregnant or breastfeeding?

Tell your doctor if you are pregnant or breastfeeding.

Interactions

What drugs and food should I avoid while taking Methylcobalamin (Vitamin B12 Methylcobalamin)?

Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb methylcobalamin.

Dosage Guidelines & Tips

How to take Methylcobalamin (Vitamin B12 Methylcobalamin)?

Use Methylcobalamin (Vitamin B12 Methylcobalamin) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Methylcobalamin (Vitamin B12 Methylcobalamin)?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Overdose Signs

What happens if I overdose on Methylcobalamin (Vitamin B12 Methylcobalamin)?

If you think you or someone else may have overdosed on: Methylcobalamin (Vitamin B12 Methylcobalamin),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Methylcobalamin (Vitamin B12 Methylcobalamin), call 911

911

Find Another Drug

Search prescription drugs, over-the counter medications, and supplements

Medical Disclaimer

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health. 

Mecobalamin – instructions for use

Mecobalamin

Instruction:

• Pharmacological action
• Readings
• Contraindications
• Pregnancy and breastfeeding
• Dosage and administration
• Side effects
• Interaction
• Precautions
• Classification

Pharmacological action

Mecobalamin – coenzyme form of vitamin B ₁₂ . Participates in the processes of transmethylation, in the synthesis of proteins and nucleic acids, in the metabolism of carbohydrates and lipids. Stimulates the monooxygenase system, has a protective effect on SH-groups and activates liver glutathione transferases. It has an anabolic effect (increasing physical performance), a regenerating effect in case of mechanical and toxic damage to the nerve trunks. In diseases of the peripheral nervous system, it reduces pain, helps to restore motor functions and reduce autonomic disorders. Having a hepatoprotective effect, it has a beneficial effect on liver function in toxic hepatitis, cirrhosis of the liver, and pancreatitis. Reduces joint damage in adjuvant arthritis, has a hematopoietic effect.

Indications

Diseases of the peripheral nervous system (complex treatment): neuralgia, polyneuropathy, radiculopathy. Chronic hepatitis, fatty degeneration of the liver, cirrhosis of the liver, chronic pancreatitis. The need to improve physical performance (including in sports).

Contraindications

Hypersensitivity.

Pregnancy and breastfeeding

Not recommended during pregnancy and breastfeeding.

Method of administration and doses

Inside, in diseases of the peripheral nervous system – 10 mg 1 time per day. In the complex therapy of liver diseases and pancreatitis – 5 mg 2 times a day or 10 mg 1 time per day. The course of treatment is 3-4 weeks. If necessary, after 1 month, repeat courses of treatment are carried out. In sports medicine – 5-10 mg once a day for 2-3 weeks.

Side effects

Allergic reactions.

Interaction

The drug is pharmaceutically incompatible with ascorbic acid, heavy metal salts (inactivation), thiamine bromide, pyridoxine, riboflavin (because the cobalt ion contained in the drug molecule destroys other vitamins).

Aminoglycosides, salicylates, antiepileptics, colchicine, preparations K ⁺ reduce absorption.

Intake enhances the development of allergic reactions caused by thiamine.

Chloramphenicol reduces the hematopoietic response.

Do not combine with drugs that increase blood clotting.

Risk of developing allergic reactions in the presence of thiamine.

Precautions

Vitamin B deficiency ₁₂ must be confirmed diagnostically before prescribing the drug, as it may mask folic acid deficiency.

During treatment, it is necessary to monitor peripheral blood parameters: on the 5th–8th day of treatment, the number of reticulocytes and iron concentration are determined.

Classification

Share this page

More on the topic

Read more about the active substance Mecobalamin:

• INN
• Reviews
• Questions
• Latin name
• Chemical formula

Information about the active substance Mecobalamin is intended for medical and pharmaceutical professionals, for reference purposes only. The instructions are not intended to replace professional medical advice, diagnosis or treatment. The information contained here may change over time. The most accurate information on the use of drugs containing the active substance Mecobalamin is contained in the manufacturer’s instructions attached to the package.

Active substance MECOBALAMINUM | Compendium – drug reference book

• Pharmacological properties
• Indications MECOBALAMIN
• Application of MECOBALAMIN
• Contraindications
• Side effects
• Special instructions
• Interactions
• Overdose
• Diagnosis
• Recommended alternatives
• Trade names

Medicinal preparations containing the active substance MECOBALAMIN

Diacobal

film-coated tablets 500 mcg blister, № 30

Kusum

Prices in pharmacies

9 0002 Neurocobal ^®

film-coated tablets 500 mcg blister, № 90

Gledpharm Ltd

Prices in pharmacies

mecobalamin is one of the active forms of vitamin B 9 0029 12 . Vitamin B ₁₂ is essential for nuclear protein and myelin synthesis, cell reproduction, normal growth and normal erythropoiesis. Compared to other forms of vitamin B ₁₂ mecobalamin at the subcellular level is better transported to neuronal organelles. It is due to this property that it is more effective in the treatment of diseases of the nervous system.

Mecobalamin is a coenzyme of methionine synthase, an enzyme involved in the conversion of homocysteine ​​to methionine in protein and DNA methylation reactions. It is known that methylcobalamin normalizes the axonal transport of protein complexes and promotes axonal regeneration. Mecobalamin also promotes myelination of neurons by stimulating the synthesis of phospholipids. In addition, methylcobalamin restores delayed synaptic transmission and reduces the content of neurotransmitters to normal levels.

The use of therapeutic doses of mecobalamin promotes detoxification processes in the nervous system due to an increase in the content of tetrahydrofolate. Mecobalamin also promotes the conversion of homocysteine ​​to S-adenosine methionine, which is a universal donor of methyl groups, which leads to the activation of transmethylation reactions.

peripheral neuropathy

is used by mouth in adults. The recommended daily dose is 1500 mcg, which is divided into 3 doses. The duration of the course of treatment depends on the nature and course of the disease and is determined individually. In the absence of a clinical effect after continuous use of the drug for 1 month, the drug should be discontinued.

hypersensitivity to mecobalamin or other components of the drug. Erythremia, erythrocytosis. Neoplasms, except in cases accompanied by megaloblastic anemia and vitamin B deficiency ₁₂ . Acute thromboembolic diseases. Angina pectoris of a high functional class.

from the gastrointestinal tract: anorexia, nausea, vomiting, diarrhea;

from the nervous system : irritability, headache, dizziness, migraine, severe anxiety disorders, agitation, insomnia;

from the side of the cardiovascular system: tachycardia, pain in the heart;

from the immune system: hypersensitivity reactions, including urticaria, anaphylactic shock, anaphylactoid reactions;

from the musculoskeletal system: muscle pain, joint pain;

on the skin side: itching, rash, acne;

from the blood and lymphatic system: thrombosis, hypercoagulability4

general disorders: increased sweating, malaise, fever.

the drug should be used with caution in patients with allergic manifestations, liver disease in history.

Long-term use of high doses of the drug is not recommended for patients whose professional activity is associated with mercury or compounds containing mercury.

Not recommended for use with clotting agents. During the treatment period, it is necessary to monitor peripheral blood counts. Regarding patients with a tendency to thrombosis and patients with angina during treatment, care must be taken and blood clotting should be monitored.

With a tendency to develop leukocytosis and erythrocytosis, the dose of the drug must be reduced or temporarily suspended treatment.

There are no data on the negative effect of the drug on the speed of psychomotor reactions.

Simultaneous use with folic acid improves the absorption and absorption of mecobalamin.

Do not co-administer other preparations containing vitamin B ₁₂ .

Chloramphenicol reduces the hematopoietic response of reticulocytes to mecobalamin.