What are the serious side effects of carbamazepine? How to identify and manage them. Explore the risks and precautions to take when using this seizure medication.

Understanding Carbamazepine’s Potential Risks

Carbamazepine, a commonly prescribed anticonvulsant medication, is generally well-tolerated, but it is important to be aware of its possible serious side effects. While these adverse reactions are rare, they can be life-threatening if not addressed promptly. This comprehensive guide will delve into the various potential complications associated with carbamazepine use, providing insights into their identification, management, and preventive measures.

Allergic Reactions: Recognizing the Warning Signs

Approximately 5 to 10% of individuals who take carbamazepine may develop a red rash within the first month of treatment. If this occurs, it is crucial to inform your healthcare provider immediately to ensure it is not the precursor to a more serious reaction. Individuals who have had a rash to related medications, such as oxcarbazepine or eslicarbazepine, are at a higher risk of experiencing a similar reaction to carbamazepine.

Severe Skin Reactions: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Carbamazepine can, in rare cases, trigger severe skin reactions, including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). These conditions typically begin with fever and flu-like symptoms, followed by the development of a rash. Ulcers or lesions may appear on the mucous membranes, eventually leading to painful blisters. If you experience any fever or rash while taking carbamazepine, it is essential to report it to your healthcare provider immediately, as these can be life-threatening conditions.

Genetic Predisposition and Risk Factors

Certain genetic factors can increase the risk of severe skin reactions to carbamazepine. Individuals with the “HLA-B*1502” allele, which is more common in certain Asian populations, such as South Asian Indians, Chinese, Thai, Filipino, Malaysian, and Korean, have a higher susceptibility to these serious skin reactions. It is recommended that individuals in these ethnic groups be tested for the HLA-B*1502 allele before starting carbamazepine treatment. If the test is positive, the benefits and risks of using this medication should be carefully weighed with your healthcare provider.

Blood Disorders: Monitoring and Vigilance

Carbamazepine can also lead to changes in blood cell counts, which may result in serious problems. While only 1 in 30,000 people taking carbamazepine will develop a blood disorder, this risk is higher than for individuals not taking the medication. Symptoms of a blood disorder may include bruising easily, fever, nosebleeds, sore throat, and tiny red spots on the skin. Regular blood tests are typically performed before and during carbamazepine treatment to monitor for any changes. If you notice any of these symptoms, contact your healthcare provider immediately, but do not stop taking the medication without their advice.

Liver Problems: Recognizing the Signs

Liver problems are another serious concern associated with carbamazepine use, although they occur in only a few individuals. Symptoms of liver issues may include black or pale-colored bowel movements, loss of appetite, nausea, vomiting, stomach pain, and yellowing of the eyes or skin. If you experience any of these signs, inform your healthcare provider right away, but do not discontinue the medication without their guidance.

Suicidal Thoughts and Behavior: Vigilance and Communication

In 2008, the FDA reviewed data from drug studies that suggested a possible link between many seizure medications, including carbamazepine, and an increased risk of suicidal thoughts and behavior. While the absolute risk is low, it is essential to be vigilant and monitor any changes in mood, behavior, or actions, as these can occur quickly. Report any concerning symptoms to your healthcare provider immediately, and do not make any changes to your medication regimen without their input.

In conclusion, while serious side effects of carbamazepine are rare, it is crucial to be aware of the potential risks and to promptly report any concerning symptoms to your healthcare provider. Regular monitoring, prompt medical attention, and a collaborative approach with your healthcare team can help ensure the safe and effective use of this important seizure medication.

Carbamazepine Basic Seizure Medication | Epilepsy Foundation

Serious side effects of carbamazepine are rare. It is important to be aware of possible reactions and what to do if they happen. Only a very small number of people have died from them.

• Read the package insert for a complete list of all reactions to carbamazepine. 
• Call your provider’s office right away if any of these problems occur. 

Allergic reactions: About 5 to 10% of people who take carbamazepine have a red rash within in the first month of taking it. If this happens, tell your health care provider to be sure that it’s not the beginning of a serious problem.

• Tell your provider if you have had a rash to oxcarbazepine or eslicarbazepine or any similar medications in the past. You could have a similar reaction to carbamazepine.

Severe skin reactions: Carbamazepine can cause rare but serious skin reactions, such as Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). These conditions may start with a fever and flu-like symptoms. Then a rash develops. Ulcers or lesions of the mucous membranes may be seen and develop into painful blisters. 

• Report any fever or rash to a health care provider as this can be a life-threatening condition. 
• These types of skin reactions happen most commonly in the second or third week after starting the medicine. Though it can happen at other times too. 
• Serious skin rashes are more common in people with a particular gene called “HLA-B*1502.” (An allele is a form of a gene that is found on a chromosome. Alleles are involved in deciding whether certain traits passed on from a parent to a child will occur. The tendency to severe drug reactions can be one of these traits.) 
  • This gene is found in ancestry or family lines from broad areas of Asia including South Asian Indians. People who are Chinese, Thai, Filipino, Malaysian, and Korean may have an increased risk for these skin reactions with carbamazepine.
  • People at risk should be tested for the HLA-B*1502 allele before starting carbamazepine. If you test positive, you should avoid using this medicine unless your provider and you decide the benefits are worth the risks. 

Blood disorders: Certain changes in blood cells may happen and lead to serious problems. Only 1 in 30,000 people who take carbamazepine will develop one of these blood disorders. This risk is higher than the risk for people who do not take carbamazepine. Some symptoms of a blood disorder may include:

• Bruising easily
• Fever
• Nosebleeds or other unusual bleeding
• Sore throat
• Sores in the mouth
• Tiny red spots on the skin

Blood tests are usually done before starting carbamazepine and again while taking it. These tests look for any changes that happen while on this medicine. Some people may have some small changes in their blood that go away on their own.  

If you notice any of these symptoms, call your health care provider right away. Do not stop taking carbamazepine without your doctor’s advice. 

Liver problems: Liver problems are another serious disorder that occurs in a few people who take carbamazepine. Some symptoms may include: 

• Black or pale color of bowel movements
• Loss of appetite
• Nausea, upset stomach, vomiting
• Stomach pain
• Yellow eyes or skin

Tell your health care provider right away if you notice any of these problems. Do not stop taking carbamazepine without your doctor’s advice. 

Suicidal thoughts and behavior: In 2008, the Food and Drug Administration (FDA) reviewed data from drug studies that showed a possible relationship between many seizure medicines and suicidal thoughts and behavior. Together, these thoughts and behavior are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, more had symptoms of suicidality than people taking a placebo or inactive substance – 3. 5 of 1,000 people taking a seizure medicine had suicidality compared to 1 of 1,000 people taking a placebo.

• Taking seizure medicines may increase the risk of having suicidal thoughts or actions.
•  Do not make any changes to the medicines without first talking to your prescribing health care provider.
•  Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.
• Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:
  • Talking or thinking about wanting to hurt yourself or end your life
  • Withdrawing from friends and family
  • Becoming depressed or having your depression get worse
  • Becoming preoccupied with death and dying
  • Giving away prized possessions

• Contact your health care provider before stopping any seizure meicine. This could possibly lead to worsening of seizure and mood. 

Tegretol | Side Effects | Dosage | Precautions

By Medicover Hospitals / 31 March 2021
Home | Medicine Tegretol

What is Tegretol?

Tegretol 100mg Tablet can be taken with or without food, but it must be taken at the same time each day. Your doctor will determine the appropriate dose and frequency of administration for you in order to control your symptoms. It can be gradually increased. Many other medications can interact with this medication, so tell your doctor about everything you’re taking to make sure it’s safe.

1. Tegretol Uses
2. Tegretol Side effects
3. Precautions
4. Dosage
5. Storage
6. Tegretol vs Gabapentin
7. Frequently Asked Questions
8. Citations

Tegretol Uses

In the case of epilepsy/seizures

In the case of trigeminal neuralgia

Tegretol 100mg Tablet reduces the nerve impulses that cause seizures. It alleviates symptoms like confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.

Nerve pain in diabetics

How to use

If you’re taking this medication in the form of suspension, shake the bottle thoroughly before each dose. Use a special measuring device or spoon to carefully measure the dose. You should not use a domestic spoon because you may not get the correct dose. Allow at least 2 hours between doses of the suspension and other liquid medications.

Tegretol Side effects:

• Balance disorder (loss of balance)
• Dizziness
• Drowsiness
• Nausea
• Slurred speech
• Vomiting
• Blurred vision
• Constipation
• Dryness in mouth
• Fatigue
• Itching

Precautions:

Tell your doctor or pharmacist about your medical history, especially if you have: decreased bone marrow function, blood disorders, glaucoma, heart disease, kidney disease, liver disease, mental/mood disorders, or mineral imbalances.

This medication should not be used during pregnancy. It can harm an unborn child. However, because untreated seizures are a serious condition that can harm both a pregnant woman and her unborn child, do not stop taking this medication unless your doctor tells you to. If you are planning for a pregnancy, discuss the benefits and risks of using this medication during pregnancy with your doctor as soon as possible. Prenatal care, including tests for birth defects, is recommended if you are pregnant. Because birth control pills, patches, implants, and injections may not work when combined with this medication, consult your doctor about alternative methods of birth control.

Interactions

Missed Dose

It is necessary to take each dose of this medication on time. If you forget a dose, contact your doctor or pharmacist as soon as possible to arrange for a new dosing schedule. Do not double the dose.

Overdose

Storage

Tegretol vs Gabapentin

Tegretol	Gabapentin
This is an anti-epileptic drug that is used to treat epilepsy.	Gabapentin is an anticonvulsant and anti-epileptic medication. It has an effect on the chemicals and nerves in the body that cause seizures and some types of pain.
It is used primarily for the treatment of epilepsy and neuropathic pain.	Gabapentin is used in conjunction with other medications to treat partial seizures in adults and children over the age of three.
Tegretol 200 is also used for treating bipolar disorder.	Gabapentin is also used to treat neuropathic pain (nerve pain) in adults caused by the herpes virus or shingles (herpes zoster).

Frequently Asked Questions:

It is a mood stabilizer. It is approved for the treatment of bipolar 1 disorder (also known as manic depression), as well as epilepsy and trigeminal neuralgia.

Carbamazepine is known to cause euphoria as a side effect. As a result, it lends itself to abuse, particularly in the adolescent population.

The most common side effects of Tegretol, especially when first starting it, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. 1 Consult your doctor if these side effects persist or are bothersome.

Memory issues may be more common with older anti-seizure medications such as Phenobarbital or Tegretol. One exception is that some people who take Topamax have difficulty concentrating and paying attention, which can impair memory.

This medication is used to treat anxiety symptoms. It has an effect on the brain by reducing abnormal electrical activity. It is used to treat mental health issues such as depression, anxiety, and post-traumatic stress disorder (PTSD).

Tegretol is a seizure medication. It reduces the nerve impulses that cause seizures and pain. Tegretol is used for treating certain types of seizures (partial, tonic-clonic, mixed). Tegretol is also used to treat nerve pain, such as trigeminal and glossopharyngeal neuralgia.

It functions by regulating electrical activity in the brain and nerves. Carbamazepine works to treat epilepsy by preventing electrical signals from accumulating in the brain’s nerve cells. It also reduces the release of glutamate, a chemical (neurotransmitter). Seizures can occur if you consume too much glutamate.

It is also beneficial in the treatment of chronic neuropathic pain. The tablets are available in 100 mg and large sizes. The maximum recommended dose is 600 mg taken twice daily (morning and near bedtime). The final dose will depend on how well the medication works for you and your tolerance to the medication.

Your Complete Guide to Trigeminal Neuralgia; A. M. Kaufmann & M. Patel, CCND Winnipeg

Your Complete Guide to Trigeminal Neuralgia; A. M. Kaufmann & M. Patel,
CCND Winnipeg

Part Two: Treatment of Trigeminal Neuralgia

II.  MedicationsA.
Introduction      Today, trigeminal neuralgia
is usually treated with drugs called anti-convulsants, which include carbamazepine
(Tegretol), phenytoin (Dilantin), oxycarbazepine
(Trileptal), and gabapentin
(Neurontin). Phenytoin was first introduced in 1942,
and in 1962 carbamazepine became the most commonly
used drug. Baclophen (Lioresal) may add to the effectiveness of these drugs.
Recently, Neurontin, (gabapentin) has been widely used
because of reduced side effects, although is more expensive and somewhat less
effective then Tegretol. The anti-convulsants are
thought to reduce TN attacks by decreasing the hyperactivity of the trigeminal
nerve nucleus in the brain stem.

     Treatment is usually initiated with one drug, such
as Tegretol or Neurontin.
The dose is increased as needed and tolerated. If any single drug proves ineffective,
alternative drugs may be tried alone or in combination with other drugs. Medical
therapy is initially effective for most patients with TN. Unfortunately, about
half of TN sufferers eventually become dissatisfied with medical therapy, because
of incomplete control of pain or drug-related side effects that are almost always
experienced. Surgical treatments are then considered.

B.
Carbamazepine (Tegretol)

     Almost all typical
TN sufferers experience significant pain relief with carbamazepine. The
starting daily dose is low, (one to two pills a day), which is gradually increased
until the pain is completely alleviated or side effects occur. Good relief of
pain may be achieved at low doses, but the usual effective dose ranges from
600 to 1600 mg divided in three or four doses per day. Even higher doses may
be required during severe attacks of pain. Once relief of the pain has been
achieved, the same dose is usually continued for at least two weeks before trying
to reduce to a minimal dosage that provides pain relief. As with all TN medications,
Tegretol may gradually be decreased during periods of remission.

     Several dose-related
side effects are often experienced including drowsiness, mental confusion, dizziness,
nystagmus (rapid movements of the eye), ataxia (decreased coordination), diplopia
(double vision), nausea, and anorexia (loss of appetite). If side effects are
severe, the daily dose of carbamazepine may be decreased for 1 to 3 days, before
trying to increase the daily dose again.

     There are also rare but serious reactions to carbamazepine
that are not dose related. These include an allergic skin rash that may form
any time after the medication is started. Two to six percent of sufferers who
take carbamazepine develop blood disorders including leukopenia or agranulocytosis
(drop in the number of white blood cells), or aplastic anemia (when the bone
marrow stops producing blood cells) . Other rare complications include liver toxicity, water intoxication (retention of water), hyponatremia (low sodium in the blood), congestive
heart failure, visual hallucinations and disorders of taste or sexual function.
Due to these complications, blood tests are usually conducted before carbamazepine
is started, and repeated intermittently. The administration of carbamazepine
should be discontinued if the white blood cell counts become abnormally low.
A physician should be notified immediately and blood tests conducted if one
experiences a fever, sore throat, stomatitis (painful infection of the mouth),
easy bruising, or petechiae (tiny red spots on the skin).

     Oxycarbamazepine
is a new form of Tegretol® that may involve fewer side effects and risks
of toxicity, but must be taken in higher doses to provide adequate pain control.

C.
Trileptal (Oxycarbazepine)

     Trileptal,
or oxycarbemazepine, is a form of Tegretol® that is becoming more widely
prescribed for a variety of conditions. It has recently been found to be effective
for some patients with trigeminal neuralgia. Like Tegretol®, it is an anti-seizure
drug, but the side effects are less severe and less frequently experienced.

The dose usually begins at 300 mg
twice a day and is gradually increased to achieve pain control. The maximum
dose is 2400-3000 mg per day. Common side effects are nausea, vomiting, dizziness,
fatigue and tremors. Less frequent symptoms are rash, respiratory infections,
double vision, and changes in electrolytes in blood. If you have had an allergic
reaction to Tegretol® (carbemazepine), then you should not try Trileptal.
As with other anti-seizure medications, increasing and decreasing the dose should
be gradual.

D.
Phenytoin (Dilantin)

     Phenytoin
relieves tic pain in over half of TN sufferers
at doses of 300 to 500 mg, divided into three doses per day.Phenytoin may also
be administered intravenously to treat severe exacerbations of TN. The maximum
dose depends upon the severity of the side effects that are experienced with
the drug. These dose-dependant side effects include nystagmus (rapid movements
of the eye), ataxia (decreased coordination), dysarthria (speech difficulty),
ophthalmoplegia (paralysis of eye movements) as well as drowsiness and mental
confusion. Other effects of the medication may include gingival hyperplasia
(enlargement of the gums in the mouth) and hypertrichosis (excessive hair growth).
Rare but serious complications may occur, including allergic skin rashes, liver
damage and blood disorders.

E. Baclophen (Lioresal)

     Baclophen
is not as effective as carbamazepine or phenytoin for TN, but may be used in
combination with these medications. The starting dose of baclophen is usually
5 mg two or three times a day, and may be gradually increased. The usual dosage
taken for complete pain relief is between 50 and 60 mg per day. Baclophen has
a short duration of function so sufferers with severe TN may need to take doses
every 3 to 4 hours.

     The
most common side effects associated with baclophen include drowsiness, dizziness,
nausea and leg weakness. The incidence of these side effects is reduced by starting
with a low dose of baclophen that is gradually increased. However, approximately
one tenth of sufferers cannot tolerate baclophen. A rare complication is a confusional
state that appears shortly after baclophen is started, but this resolves quickly
when therapy is stopped. Baclophen should not be discontinued abruptly after
prolonged use because hallucinations or seizures may occur. If these withdrawal
symptoms do occur, the previous dose of baclophen is usually re-instituted and
then gradually reduced.

F. Gabapentin (Neurontin)

     Gabapentin
is an anti-epileptic drug that is structurally related to the neurotransmitter
GABA. This drug is almost as effective as carbamazepine
but involves fewer side effects.The
starting dose is usually 300mg three times a day and this is increased to a
maximal dose. The most common adverse reactions include somnolence (sleepiness),
ataxia (decreased coordination), fatigue, and nystagmus (rapid movements of
the eye). There is no known interaction with Tegretol
or Dilantin, permitting usage of these drugs in combination
with Neurontin. As with all of these drugs, rapid discontinuation should be
avoided as severe withdrawal reactions may occur.

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Web-Site at the Centre for
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A.
M. Kaufmann & M. Patel
Centre for Cranial Nerve Disorders
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M. Kaufmann & M.
Patel
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Tegretol (Carbamazepine) for Bipolar Disorder

What is Tegretol?

Tegretol is a medication known as an anticonvulsant that is used to treat the manic symptoms of bipolar disorder. It is also used to treat seizures and nerve pain.

When did the U.S. Food and Drug Administration (FDA) approve the medication?

Tegretol was first approved by the FDA in 1968.

Is there a generic version of Tegretol?

Yes, the generic version is known as carbamazepine and is sold in the U.S.

Are there any major differences between Tegretol and other medications used to treat bipolar disorder?

Tegretol belongs to the class of medications known as anticonvulsants. Anticonvulsants are sometimes taken to treat or prevent the manic episodes associated with bipolar disorder. Tegretol may be prescribed alone or in combination with other medications to treat symptoms.

What warning information do I need to know about Tegretol?

Tegretol may cause a life-threatening allergic reaction known as Stevens-Johnson Syndrome or toxic epidermal necrolysis. This can cause damage to your internal organs or skin. The risk factor is genetic, with people of Asian ancestry being at higher risk. Talk to your doctor about getting genetic testing to evaluate the risk of taking Tegretol. Tegretol can also decrease the number of blood cells in the body, so talk to your doctor if you already have a low number or are taking other medications that increase this risk.

Article continues below

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Take our 2-minute Bipolar quiz to see if you or a loved one may benefit from further diagnosis and treatment.

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Can children take Tegretol?

Children over the age of 6 can be prescribed Tegretol for seizures. Talk to your doctor about the risks and benefits and potential side effects to monitor.

Are there potential interaction issues for people taking Tegretol and any other drugs?

There are hundreds of drugs which are known to interact with Tegretol in major, moderate, or mild ways, so let your doctor know what other medications you are taking before you begin taking the medication. Some of these might include medication for mental illness such as depression or anxiety, antifungals, seizure medications, HIV protease inhibitors, malaria medications, sleeping medications, and any vitamins or over the counter prescriptions you might be taking. Tegretol may also decrease the effectiveness of hormonal contraceptives.

Are there any other medical conditions that would make someone ineligible for Tegretol therapy?

Talk to your doctor about other medical conditions before you take Tegretol, such as glaucoma, heart disease, kidney disease, thyroid or liver disease, or a history of psychosis. Also tell your doctor if you have a history of low blood cell count.

What is the typical dose that would be prescribed to someone taking Tegretol?

Dosage will vary depending on the age of the patient and the condition being treated.

What do I do if I miss a dose?

Take the dose of Tegretol when you remember, but skip the missed dose if it is almost time for your next dose. You should never take extra doses of the medication to make up for missed doses.

What side effects can Tegretol cause?

Common side effects can include:
• nausea
• dry mouth
• constipation
• dizziness
• drowsiness
• mild rash

It also is recommended that you wait to drive or operate machinery until you know how the medication affects you and to avoid alcohol and illegal drugs while on the medication, as they can worsen adverse effects. Report major side effects to your doctor immediately, which can include swelling, shortness of breath, skin reaction, and fever. Report side effects to the FDA at 1-800-FDA-1088 or online.

What are the potential psychological side effects of taking Tegretol?

Anticonvulsant medications sometimes cause suicidal thoughts and behaviors in a small percentage of people who take the medication. Seek medical help if you experience these thoughts or other changes in your behavior or mood.

What are the potential long-term effects of taking Tegretol?

Tegretol can cause lower blood counts and lower sodium levels. Your doctor may want to monitor these periodically while you’re taking the medication.

Is it safe for a woman who is pregnant, about to become pregnant, or nursing to take Tegretol?

Tegretol can cause birth defects and fetal harm when taken during pregnancy. The drug can be transferred via breast milk and potentially harm a baby. Therefore, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing before you take Tegretol.

Can symptoms occur if Tegretol is discontinued?

It’s important not to discontinue use of the drug before talking with your doctor. Withdrawal symptoms of Tegretol can include sleep problems, increased anxiety, numbness in limbs, joint pain, shaking, and the return of manic or depressive symptoms.

What should I do if I overdose on Tegretol?

An overdose of Tegretol could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include abnormal or uncontrollable movements, restlessness, seizures, loss of balance, dizziness, drowsiness, blurred vision, slower or irregular breathing, rapid heartbeat, nausea, vomiting, trouble urinating, and unconsciousness.

Is Tegretol habit-forming?

Tegretol has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur.

How much does Tegretol cost?

According to goodrx.com, 60 tables of 200 mg generic carbamazepine cost approximately $65. 60 tablets of 200 mg Tegretol cost approximately $150.

Are there any disadvantages to Tegretol?

The biggest disadvantages of Tegretol are potential side effects which include severe allergic reaction and decreased blood cell count. Pregnant women are also typically advised not to take the medication due to the risk of birth defects.

DISCLAIMER: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other healthcare providers. This article mentions drugs that were FDA-approved and available at the time of publication and may not include all possible drug interactions or all FDA warnings or alerts. The author of this page explicitly does not endorse this drug or any specific treatment method. If you have health questions or concerns about interactions, please check with your physician or go to the FDA site for a comprehensive list of warnings.

Article Sources

FDA – Tegretol
NIH – Carbamazepine

Last Updated: Nov 25, 2018

Carbamazepine side effects & info on epilepsy drug – Patient

About carbamazepine

If you have epilepsy, it means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different functions of your body, so the symptoms that occur during a seizure will depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, and consciousness, or a combination of these. The seizures can be prevented in most people by suitable antiepileptic medication. Carbamazepine is a commonly used medicine. It works by stabilising the electrical activity of your brain, which prevents the seizures from occurring.

Carbamazepine is also prescribed as a treatment for severe burning or stabbing pains in the face (called trigeminal neuralgia), and occasionally as part of the treatment for bipolar disorder (sometimes called manic depression). This is because it can modify some types of pain, and control some mood disorders. If you have been given carbamazepine for these (or any other reasons), ask your doctor if you have questions about your treatment.

Before taking carbamazepine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking carbamazepine it is important that your doctor knows:

• If you are pregnant, trying for a baby or breastfeeding.
• If you have any problems with the way your kidneys work, or with the way your liver works.
• If you have any heart condition.
• If you have increased pressure in your eyes, a condition known as glaucoma.
• If you have ever had any problems affecting your bone marrow.
• If you have a rare inherited blood disorder called porphyria.
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
• If you have ever had an allergic reaction to a medicine.

How to take carbamazepine

• Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about carbamazepine and will provide you with a full list of the side-effects which you may experience from taking it.
• Take carbamazepine exactly as your doctor tells you to. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. If you are taking it for epilepsy, it is likely you will be asked to take one or two doses every day. Doses for children are tailored to their age and weight. If you have been prescribed it for another reason, you could be asked to take a dose three, or even four, times a day. Your dose will be printed on the label of the pack to remind you about what the doctor said to you.
• Try to take your doses of carbamazepine at the same times each day. Having a routine will help you to remember to take your doses regularly. Swallow the tablet with a drink of water. You can take most preparations of carbamazepine either before or after meals. If, however, you have been supplied with chewable tablets, you should take these during a mealtime.
• If you have been given carbamazepine prolonged-release tablets you must swallow the tablet whole – do not chew or crush the tablet.
• If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

• When you first start a new treatment for epilepsy there may be a change in the number or type of seizures you experience. Your doctor will advise you about this.
• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You may need to have blood tests from time to time.
• Different formulations and brands of carbamazepine can act in a slightly different way in your body. Because of this, it is important that you continue to take tablets from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
• If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines interfere with carbamazepine, and carbamazepine can also alter the way other medicines work.
• Ask your doctor for advice before drinking alcohol while you are on carbamazepine. Your doctor may recommend you do not drink alcohol because it increases the risk of side-effects.
• People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to start driving again. This will usually be after a year free of seizures.
• Carbamazepine may harm an unborn child so you must avoid getting pregnant. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.
• While you are being treated for epilepsy there is a small risk that you may develop mood changes, distressing thoughts and feelings about suicide. If this happens, you must tell your doctor about it straightaway.
• You need to take carbamazepine regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.

Can carbamazepine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with carbamazepine. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. Many of the side-effects can occur when first starting carbamazepine, but should settle down as your body adjusts to the new medicine. Speak with your doctor if they continue or become troublesome.

Important: your doctor will discuss with you the possibility that carbamazepine can cause liver, blood and skin disorders. Although these occur less commonly than the side-effects listed above, it is important that you contact your doctor straightaway if you experience any of the following symptoms:

• A high temperature (fever), sore throat or swollen glands.
• A severe skin rash.
• Mouth ulcers.
• Unexplained bruising or bleeding.

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

How to store carbamazepine

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Tegretol Retard – (Carbamazepine) | MyTeleHealth

Why have I been prescribed Tegretol?

• The active ingredient of Tegretol is carbamazepine. 
• Carbamazepine is one of a group of medicines called anticonvulsants. 
• It is used to treat epilepsy. 
• Carbamazepine is also used to treat a painful condition of the face (trigeminal neuralgia) and also may be used to help prevent mood swings.

How does it work?

It works by decreasing the excitability of nerve cells and preventing them firing inappropriately.

When and how do I take it?

Tegretol is always (except possibly on the first day) given in divided daily doses, i.e. 2 to 4 times a day, depending on your medical condition.

• Take Tegretol during or after a meal.
• Swallow the tablets with some liquid; if necessary, the tablets may be broken in half along the line.

Do not drink grapefruit juice or eat grapefruit since this can increase the effect of Tegretol. Other juices, like orange juice or apple juice, do not have this effect.

What’s the dose?

Treatment of epilepsy is usually started at 100 to 200 mg once or twice a day in adults. The dosage is then gradually increased to 800 to 1200mg a day ( i.e. 40–60 mls oral suspension), divided in 2 or 3 intakes.

Treatment in children is usually started at 100 to 200 mg day (based on 10 to 20 mg/kg body weight daily) and kept at 400 to 800 mg a day. Adolescents may receive between 600 and 1000 mg a day.

Tegretol is not suitable for children under 5 years.

For trigeminal neuralgia the starting dosage of 200 to 400 mg a day is slowly raised until there is no pain usually 200 mg 3 to 4 times a day.

For elderly patients a lower starting dose, 100 mg twice a day, is recommended.

For mood disorders the usual dosage is 400 to 600 mg a day.

For alcohol withdrawal symptoms the usual dosage is 600–800 mg a day.

Could it interact with other tablets?

If you are already taking any of the following medicines, tell your doctor. It may affect your dose of Tegretol or increase the risk of side effects:

• Phenobarbital, Phenytoin, Primidone, Valproic Acid, Felbamate, Ethosuximide, Tiagabine, Lamotrigine, Flunarizine (other antiepileptics)
• Antibiotics include Rifampicin, Josamycin, Clarithromycin. Troleandromycin, Erythromycin, Isoniazid, Doxycycline
• Itraconazole, Ketoconazole, Voriconazole, Fluconazole, Caspofungin (treatment of fungal infections)
• Ritonavir, Indinavir (anti-viral medicine)
• Praziquantel (to treat worm infections
• medicine for heart problems e.g. Verapamil, Digoxin, Diltiazem, Quinidine, Hydroquinidine, or for high blood pressure eg. Dihydropyridines (such as Felodipine), Propranolol
• Acetazolamide (to treat glaucoma)
• Hydrochlorothiazide, Furosemide (diuretics or ‘water tablets’)
• Dextropropoxyphene/Propoxyphene, Methadone, Tramadol, Fentanyl, Paracetamol, Phenazone (painkillers)
• Midazolam (sedative)
• Fluoxetine, Viloxazine, Desipramine, Imipramine, Fluvoxamine, Trazadone, Nortriptyline, Amitriptyline, Clomipramine (antidepressants)
• Clonazepam, Ethosuximide, Alprazolam, Clobazam (medicines for anxiety)
• Haloperidol, Bromperidol, Lithium, Olanzapine, Quetiapine, Risperidone, Clozapine (to treat mental illness)
• Nicotinamide in high doses (vitamin of the B group)
• Cimetidine (for the treatment of ulcers)
• Theophylline (for asthma)
• Corticosteroids (eg. Prednisolone, Dexamethasone)
• Ciclosporin, Tacrolimus, Sirolimus (immunosuppressants)
• Cisplatin, Doxorubicin, Procarbazine (anti-cancer medicine)
• Anticoagulant drugs such as Warfarin, Phenprocoumon and Dicumarol
• Muscle relaxants (e.g. Pancuronium)
• Isotretinoin (to treat acne)
• Danazol (treatment for endometriosis)
• contraceptive “pill”: It is advised to use another form of contraception.
• Other medicines containing oestrogens/progestogens, HRT treatment
• Terfenadine, Loratadine (for allergies)
• Bupropion (anti-smoking treatment)
• Methylphenidate (to treat ADH disorder)
• The herbal remedy St. Johns Wort (Hypericum perforatum) should not be taken at the same time as this medicine. If you already take St. Johns Wort, consult your doctor before stopping the St. John’s Wort preparations.

Herbal products should also only be taken after talking with your doctor.

What are the possible risks or side-effects?

Like most medicines, Tegretol can have side effects. Side effects aremore common at the start of treatment, but usually disappear after a few days or when the dose is adjusted to be right for you. 

Common effects seen in less than 1 in 10 patients but more than 1 in 100, include: 

• feeling dizzy
• feeling tired or drowsy
• suffering from skin rashes and a loss of co-ordination

Tell your doctor straight away if you:

• notice a skin rash or a severe skin reaction
• suffer from a persistent sore throat, fever or both
• feel feverish
• suffer from mouth ulcers or notice unusual bruising or bleeding of your skin
• get a throbbing headache
• stiff neck and become sensitive to bright light
• have difficulty breathing
• have a combination of symptoms including painful joints or muscles and a rash

These are rare effects, seen in less than 1 in 1000 patients but more than 1 in 10,000.

Very common side effects (affecting more than or equal to 1 in 10 patients): 

Common side effects (affecting less than 1 in 10 patients):

• swelling of the ankles, feet or lower legs (oedema)
• changes in behaviour
• confusion 
• weakness
• increase in seizures (fits)
• blurred vision
• double vision
• itching with redness and swelling of the eye (conjunctivis)
• feeling pressure/pain in the eye (signs of increased pressure in the eye)
• trembling
• uncontrolled body movements
• muscle spasms
• uncontrolled eye movements

Uncommon effects, seen in less than 1 in 100 patients but more than 1 in 1000, include: 

Can I drink Alcohol while taking it?

This medicine interacts with alcohol and concomitant use should be avoided.

What if I’m pregnant/breastfeeding?

• If you are planning to become pregnant, talk to your doctor first.
• If you are pregnant and need to take an anticonvulsant, you are likely to be taking only one anticonvulsant. 
• Your doctor will monitor you and your unborn child closely. 
• Breast feeding while taking Tegretol is not recommended. If you do breast feed and you take Tegretol, tell your doctor straight away if your child becomes very drowsy or is slow to put on weight.

If you have any more questions please ask your Pharmacist.

Remember to keep all medicines out of reach of children
Please Note: We have made every effort to ensure that the content of this information sheet is correct at time of publish, but remember that information about drugs may change. This sheet does not list all the uses and side-effects associated with this drug. For full details please see the drug information leaflet which comes with your medicine. Your doctor will assess your medical circumstances and draw your attention to any information or side-effects which may be relevant in your particular case.

References:

https://en.wikipedia.org/wiki/Carbamazepine

http://www.drugs.com/tegretol.html

http://www.rxlist.com/tegretol-drug.htm

https://www.medicines.org.uk/emc/medicine/1328

http://www.fda.gov/downloads/Drugs/DrugSafety/UCM246796.pdf

https://www.pharma.us.novartis.com/product/pi/pdf/tegretol.pdf

Carbamazepine | Health Navigator NZ

Carbamazepine is used to treat epilepsy, control some mood disorders such as bipolar disorder and for some types of pain such as nerve pain. Find out how to take it safely and possible side effects. Carbamazepine is also called Tegretol.

What is carbamazepine?

Carbamazepine has many different uses including the treatment of epilepsy by preventing seizures, the control of some mood disorders such as bipolar disorder and the treatment of some types of nerve pain involving the face, head and neck (trigeminal neuralgia). Carbamazepine blocks certain kinds of nerve activity. In New Zealand, carbamazepine is available as:

• Tegretol liquid (syrup) 100 mg in 5 mL
• Tegretol 200 mg and 400 mg tablets (white tablets)
• Tegretol CR 200 mg tablets (beige-orange tablets)
• Tegretol CR 400 mg tablets (brown-orange tablets)

Dose

• The dose of carbamazepine is different for different people.
• Your doctor will start you on a low dose, and increase your dose slowly over a few weeks. This will help to reduce the risk of side effects.
• Always take your carbamazepine exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it, and any special instructions.

How to take carbamazepine

• Carbamazepine can be taken with food if you have stomach upset.
• Take your doses at the same times each day, to help you to remember to take it.
• Carbamazepine is available as a liquid or as tablets.

• Missed dose: If you forget to take your dose, take it as soon as you remember that day. But, if it is nearly time for your next dose (within 2 to 3 hours), just take the next dose at the right time. Do not take double the dose.
• Keep taking carbamazepine every day. It may take a few weeks before you experience the full benefits of carbamazepine. For people with nerve pain, carbamazepine can provide relief within a few days. Do not stop taking carbamazepine suddenly; speak to your doctor or nurse before stopping.  See tips to help you remember to take your medicines regularly.

Precautions – before starting carbamazepine

• Are you pregnant or trying for a baby?
• Do you have problems with the way your kidneys or liver works?
• Do you have a heart condition?
• Do you have any problems affecting your bone marrow?

If so, it’s important that you tell your doctor before you start carbamazepine. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Side effects

Like all medicines, carbamazepine can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

Interactions

• Carbamazepine interacts with many medications and herbal supplements, especially anti-viral medicines, anti-clotting medicines such as warfarin and oral contraceptives. Always check with your doctor or pharmacist before starting carbamazepine or before starting any new medicines.
• It may also interact with medicines that are available without a prescription such as cough, cold and flu medication, or anti-allergy medication. Check with your pharmacist before taking any new medicines.

Learn more

Tegretol Medsafe Consumer Information Sheet
For adults: Carbamazepine New Zealand Formulary Patient Information
For children: Carbamazepine New Zealand Formulary for Children

References

1. Carbamazepine New Zealand Formulary Patient Information
2. Carbamazepine New Zealand Formulary for Children
3. Tegretol Medsafe Data sheet
4. Managing patients with neuropathic pain BPAC, May 2016
5. Bipolar disorder: identifying and supporting patients in primary care BPAC, July 2014

Tegretol instructions for use: indications, contraindications, side effects – description of Tegretol tab. 200 mg: 50 pcs. (34562)

Carbamazepine: Pediatric Medication | Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ^® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

Trade names: USA

Carbatrol; Epitol; Equetro; TEGretol; TEGretol-XR

Trade names: Canada

APO-CarBAMazepine; DOM-CarBAMazepine; DOM-CarBAMazepine CR; Mazepine; PMS-CarBAMazepine; PMS-CarBAMazepine CR; PMS-CarBAMazepine-CR; SANDOZ CarBAMazepine CR; SANDOZ CarBAMazepine [DSC]; TARO-CarBAMazepine; TEGretol; TEGretol CR; TEVA-Carbamazepine

Warning

• Cases of dangerous abnormalities in blood cell levels have occurred, such as aplastic anemia and a variant of low leukocyte counts.Tell your doctor right away if your child feels very tired or weak, has a fever, chills, shortness of breath, unexplained bruising and bleeding, or purple spots on the skin.
• If the child has any signs of infection, such as fever, chills, flu-like symptoms, very bad sore throat, sore ear or sinuses, cough, increased or discolored sputum, pain when urinating mouth ulcers or non-healing wounds, see your child’s doctor immediately.
• Possible severe skin reaction (Stevens-Johnson syndrome / toxic epidermal necrolysis). This can lead to serious and permanent health problems and sometimes death. Get medical help right away if your child has symptoms such as redness, skin swelling with blistering or scaling (with or without a fever), redness or irritation of the eyes, painful sores on the lining of the mouth, throat, nose, or eyes …
• People with a particular gene (HLA-B * 1502) are more likely to have serious and sometimes fatal skin reactions associated with this drug. This gene is most common among Asians, including South Asian Indians. If you have any questions, consult your doctor.
• People with a particular gene (HLA-A * 3101) may be more likely to have serious allergic reactions associated with this drug. Allergic reactions can lead to death.If you have any questions, consult your doctor.

What is this drug used for?

• Used to treat seizures.
• It is used to treat pain syndrome caused by damage to the facial nerve.
• This medication is used to treat bipolar disorder.
• This drug can be given to children for other indications. Consult your doctor.

What should I tell my doctor BEFORE my child takes this drug?

• If your child is allergic to this drug, any of its ingredients, other drugs, foods, or substances.Tell your doctor about the allergy and how your child has it.
• If your child has kidney disease.
• If your child has any of the following: bone marrow disease or porphyria.
• If your child’s body is unable to break down fructose, consult a doctor. Some of these drugs contain sorbitol.
• If your child is taking any drugs (prescription or over-the-counter, natural drugs, and vitamins) that should not be taken with this drug — for example, some drugs for HIV, other infections, or seizures.There are many medicines that should not be taken at the same time as this medicine.
• If your child has taken drugs for depression or some other medical condition in the past 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.

This list of drugs and diseases that may be adversely associated with this drug is not exhaustive.

Talk to your doctor or pharmacist about all medications your child is taking (prescription and over-the-counter, natural products, and vitamins) and any health concerns. You need to make sure that this drug is safe for your child’s illness and in combination with other drugs that he or she is already taking. You should not start, stop, or change the dosage of any drug your child is taking without talking to your doctor.

What do I need to know or do while my child is taking this drug?

• Tell all health care providers for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
• Perform blood tests as directed by your healthcare practitioner. Please consult your doctor.
• Check your child’s eyesight as directed by your doctor.
• This drug may interfere with some lab tests. Tell all healthcare professionals and laboratory staff providing your child’s healthcare that your child is taking this drug.
• Alcohol may interact with this drug. Make sure your child does not drink alcohol.
• Consult with your child’s doctor before using marijuana, other forms of cannabis, prescription or over-the-counter drugs that may slow down your child’s actions.
• Consult a pediatrician if your child frequently drinks grapefruit juice or eats grapefruit.
• Have your child avoid tasks or activities that require attention until you see how this drug is working for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
• Do not suddenly stop giving this drug to your child without talking to your doctor. This can increase the risk of seizures. If your child needs this drug, stop taking this drug gradually, as directed by the doctor.
• Consult a doctor if seizures change or worsen after starting this drug.

If your child is or may be sexually active:

• Some pregnancy tests may not give results when you take this drug.Consult your doctor.
• The contraceptive effectiveness of birth control pills and other hormonal contraceptives may be reduced. Make sure your child is also using another form of birth control, such as a condom, while taking this drug.

If your daughter is pregnant or breastfeeding:

• If your daughter uses the drug during pregnancy, the drug may have a harmful effect on the fetus.If your daughter is pregnant or becomes pregnant while taking this drug, call her doctor right away.
• Tell the doctor if your daughter is breastfeeding. You will need to be consulted about the possible risks to the child.

What side effects should I report to my child’s healthcare provider right away?

WARNING / CAUTION: Although rare, this drug can cause very serious and sometimes deadly side effects in some people.Call your child’s doctor right away or get medical attention if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

• Signs of an allergic reaction such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
• Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confusion, weakness, seizures, balance problems.
• Change of speech.
• Hallucinations (a person sees or hears something that is not in reality).
• Change in vision.
• Difficulty walking.
• Severe and sometimes deadly side effects have been reported in patients using drugs similar to this drug for seizures.If your child has swollen lymph nodes, fever, rash, chest pains, signs of kidney damage such as urinary retention or changes in urine output, signs of liver damage such as dark urine, feeling tired, or not feeling hungry , nausea or abdominal pain, light colored stools, vomiting, yellow skin or eyes, see a doctor immediately.
• Like other drugs used to treat seizures, this drug in rare cases may increase the risk of suicidal ideation or behavior.This risk may be higher in people who have attempted suicide or have had suicidal thoughts in the past. See your doctor right away if you develop or worsen symptoms such as depression, nervousness, anxiety, irritability, panic attacks, or other mood or behavior disorders. In case of suicidal thoughts or attempted suicide, contact your doctor immediately.
• Patients can develop a very serious and sometimes fatal complication called neuroleptic malignant syndrome.Call your child’s doctor right away if the child has a fever, muscle cramps or stiffness in the muscles, dizziness, very bad headache, confusion, changes in thinking, tachycardia, a feeling of irregular heartbeat, and profuse sweating.
• A heart problem, such as heart failure and certain heart rhythm problems, has happened with this drug. Sometimes these heart problems have resulted in death.If your child has a fast, slow heartbeat, or an irregular heartbeat, severe dizziness or fainting, shortness of breath, weight gain, or swelling in the arms or legs, see your child’s healthcare provider right away.
• A very severe reaction called angioedema has occurred with this drug. Sometimes this reaction can be life-threatening. Symptoms may include swelling of the hands, face, lips, eyelids, tongue, or throat, difficulty breathing or swallowing, or uncharacteristic hoarseness.Call your doctor right away if your child has any of these symptoms.

What are some other side effects of this drug?

Any drug can have side effects. However, many people have little or no side effects. Call your child’s doctor or get medical help if any of these or other side effects bothers your child or does not go away:

• Feeling dizzy, sleepy, tired, or weak.
• Nausea or vomiting.
• Dry mouth.
• Constipation.

This list of potential side effects is not exhaustive. If you have any questions about side effects, talk to your child’s doctor. Talk to your child’s doctor about side effects.

You can report side effects to the National Health Office.

What is the best way to give this drug?

Give this drug to your child as directed by the doctor.Read all the information provided to you. Follow all instructions strictly.

Sustained-release capsules:

• Give this drug with or without food.
• Have your child swallow whole. Tell your child not to chew, crush, or crush the tablet.
• You can pour the contents of the capsule into applesauce or other soft foods. Have your child swallow right away without chewing and drink with water or juice.

All other oral preparations:

• Give this drug with food.

Chewable Tablets:

• Make sure your child chews the drug thoroughly before swallowing.

Extended release tablets:

• Have your child swallow whole. Tell your child not to chew, crush, or crush the tablet.
• Do not give broken or chipped tablets to a child.
• The tablet shell can sometimes be seen in the stool of a child. This is normal and not a cause for concern.
• If your child has trouble swallowing this drug, talk to your doctor. There may be other ways of administering this drug.

Liquid (suspension):

• Shake well before use.
• Care should be taken when measuring liquid doses. Use the dispenser that comes with the medicine.If a dispenser is not included in the package, ask your pharmacist for a dosing product for this drug.
• Do not mix with other liquid medicines.
• Do not give this drug to your child at the same time as any other liquid medicine.

What if my child misses a dose of a drug?

• Give the missed dose as soon as possible.
• If it is time for your child to take the next dose, do not take the missed dose and then return to your child’s normal dosage schedule.
• Do not give a double dose at the same time or additional doses.

How do I store and / or discard this drug?

• Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
• Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs.Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

General information about medicines

• If your child’s symptoms or health problems do not improve, or if they get worse, see your child’s doctor.
• Do not share your child’s medicine with others or give anyone’s medicine to your child.
• Some medicines may come with other patient information sheets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other healthcare professional.
• If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Use of information by the consumer and limitation of liability

This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are appropriate for a particular patient. This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient.Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional. Please consult your doctor for complete information on the possible risks and benefits of taking this drug.Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

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© UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

Tegretol – action, indications, side effects, drug interactions composition, instructions, reviews

Home »Medicines» Tegretol – action, indications, side effects, drug interactions

composition, instructions, reviews

Tegretol CR is a drug with psychotropic, antiepileptic and neurotropic effects.It is widely used in neurology. It is especially recommended for the treatment of ailments such as bipolar disorder, trigeminal pain, epilepsy, manic syndromes, multiple sclerosis or alcohol abstraction in drug addicts. The medicine is only available with the present prescription. Depending on the means, dose and form, the price of tegretol ranges from 14 to 26 zlotys.

tegretol CR it contains the active ingredient carbamazepine and is available in two different doses – 200 mg and 400 mg.Also comes in the form of a syrup. Carbamazepine has a membrane-stabilizing effect on nerve cells that are overstimulated. The product alleviates the effects of alcohol withdrawal in people who depend on it, reduces aggressiveness and irritability, and repels feelings of anxiety and depression. In addition, it prevents bouts of pain in the trigeminal nerve.

Your doctor will determine your dose. In epilepsy, it usually starts with a dose of 100-200 twice a day and increases gradually.For the treatment of bipolar disorder and manic syndromes, the optimal dose is 400-1600 mg, for alcohol withdrawal syndrome 200 mg 3 times a day, and for trigeminal nerve pain 200-400 mg per day.

Before using the drug tegretol CR , carefully read its instructions. Do not take this medication if you are allergic to any of its ingredients. Not indicated for people with hepatic porphyria, atrioventricular blocks, bone marrow disorders. In addition, MAO inhibitors should be discontinued two weeks before starting carbamazepine therapy.

The drug, like any other drug, can cause side effects and more often include, among others, dizziness and headache, drowsiness, double vision, vomiting, nausea, fatigue, dermatitis, hives, weight gain, edema and fluid retention. In addition, dangerous side effects such as arrhythmias, liver failure, embolic blood clots, and more can rarely occur. In case of adverse reactions, consult a doctor immediately.

Tegretol should not be taken, for example, MAO inhibitors, drugs that increase the amount of carbamazepine in the blood, incl.