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Medicine tegretol: Drug Database | Medical Device Database


Carbamazepine Basic Seizure Medication | Epilepsy Foundation

Serious side effects of carbamazepine are rare. It is important to be aware of possible reactions and what to do if they happen. Only a very small number of people have died from them.

  • Read the package insert for a complete list of all reactions to carbamazepine. 
  • Call your provider’s office right away if any of these problems occur. 

Allergic reactions: About 5 to 10% of people who take carbamazepine have a red rash within in the first month of taking it. If this happens, tell your health care provider to be sure that it’s not the beginning of a serious problem.

  • Tell your provider if you have had a rash to oxcarbazepine or eslicarbazepine or any similar medications in the past. You could have a similar reaction to carbamazepine.

Severe skin reactions: Carbamazepine can cause rare but serious skin reactions, such as Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). These conditions may start with a fever and flu-like symptoms. Then a rash develops. Ulcers or lesions of the mucous membranes may be seen and develop into painful blisters. 

  • Report any fever or rash to a health care provider as this can be a life-threatening condition. 
  • These types of skin reactions happen most commonly in the second or third week after starting the medicine. Though it can happen at other times too. 
  • Serious skin rashes are more common in people with a particular gene called “HLA-B*1502.” (An allele is a form of a gene that is found on a chromosome. Alleles are involved in deciding whether certain traits passed on from a parent to a child will occur. The tendency to severe drug reactions can be one of these traits.) 
    • This gene is found in ancestry or family lines from broad areas of Asia including South Asian Indians. People who are Chinese, Thai, Filipino, Malaysian, and Korean may have an increased risk for these skin reactions with carbamazepine.
    • People at risk should be tested for the HLA-B*1502 allele before starting carbamazepine. If you test positive, you should avoid using this medicine unless your provider and you decide the benefits are worth the risks. 

Blood disorders: Certain changes in blood cells may happen and lead to serious problems. Only 1 in 30,000 people who take carbamazepine will develop one of these blood disorders. This risk is higher than the risk for people who do not take carbamazepine. Some symptoms of a blood disorder may include:

  • Bruising easily
  • Fever
  • Nosebleeds or other unusual bleeding
  • Sore throat
  • Sores in the mouth
  • Tiny red spots on the skin

Blood tests are usually done before starting carbamazepine and again while taking it. These tests look for any changes that happen while on this medicine. Some people may have some small changes in their blood that go away on their own.  

If you notice any of these symptoms, call your health care provider right away. Do not stop taking carbamazepine without your doctor’s advice. 

Liver problems: Liver problems are another serious disorder that occurs in a few people who take carbamazepine. Some symptoms may include: 

  • Black or pale color of bowel movements
  • Loss of appetite
  • Nausea, upset stomach, vomiting
  • Stomach pain
  • Yellow eyes or skin

Tell your health care provider right away if you notice any of these problems. Do not stop taking carbamazepine without your doctor’s advice. 

Suicidal thoughts and behavior: In 2008, the Food and Drug Administration (FDA) reviewed data from drug studies that showed a possible relationship between many seizure medicines and suicidal thoughts and behavior. Together, these thoughts and behavior are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, more had symptoms of suicidality than people taking a placebo or inactive substance – 3. 5 of 1,000 people taking a seizure medicine had suicidality compared to 1 of 1,000 people taking a placebo.

  • Taking seizure medicines may increase the risk of having suicidal thoughts or actions.
  •  Do not make any changes to the medicines without first talking to your prescribing health care provider.
  •  Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.
  • Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:
    • Talking or thinking about wanting to hurt yourself or end your life
    • Withdrawing from friends and family
    • Becoming depressed or having your depression get worse
    • Becoming preoccupied with death and dying
    • Giving away prized possessions
  • Contact your health care provider before stopping any seizure meicine. This could possibly lead to worsening of seizure and mood. 

Tegretol | Side Effects | Dosage | Precautions

By Medicover Hospitals / 31 March 2021
Home | Medicine Tegretol

What is Tegretol?

  • Tegretol 100mg Tablet is an anti-epileptic drug that is used to treat epilepsy. It aids in the prevention of certain types of seizures (fits). It is also used to treat trigeminal neuralgia, a painful condition of face, head, and neck, as well as diabetes-related nerve pain (diabetic neuropathy).
  • Tegretol 100mg Tablet can be taken with or without food, but it must be taken at the same time each day. Your doctor will determine the appropriate dose and frequency of administration for you in order to control your symptoms. It can be gradually increased. Many other medications can interact with this medication, so tell your doctor about everything you’re taking to make sure it’s safe.
    1. Tegretol Uses
    2. Tegretol Side effects
    3. Precautions
    4. Dosage
    5. Storage
    6. Tegretol vs Gabapentin
    7. Frequently Asked Questions
    8. Citations

    Tegretol Uses

    In the case of epilepsy/seizures

  • Tegretol 100mg Tablet reduces the nerve impulses that cause seizures. It alleviates symptoms like confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
  • This medication does not cause physical or psychological dependence (addiction), but it should not be stopped abruptly. To be effective, it must be taken on a regular basis as prescribed. Missed doses may result in seizure.
  • In the case of trigeminal neuralgia

  • Tegretol 100mg Tablet reduces the nerve impulses that cause seizures. It alleviates symptoms like confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
  • Nerve pain in diabetics

  • Tegretol 100mg Tablet relieves nerve pain by reducing the nerve impulses that cause it. This medication does not cause physical or psychological dependence (addiction), but it should not be stopped abruptly. To be effective, it must be taken on a regular basis as prescribed.
  • How to use

  • Before you begin using carbamazepine, and each time you get a refill, read the Medication Guide provided by your pharmacist.
  • Take this medication orally with food. If you’re using chewable tablets, make sure you chew them thoroughly before swallowing.
  • If you’re taking this medication in the form of suspension, shake the bottle thoroughly before each dose. Use a special measuring device or spoon to carefully measure the dose. You should not use a domestic spoon because you may not get the correct dose. Allow at least 2 hours between doses of the suspension and other liquid medications.
  • Tegretol Side effects:

  • Some of the common side effects of Tegretol are:
    • Balance disorder (loss of balance)
    • Dizziness
    • Drowsiness
    • Nausea
    • Slurred speech
    • Vomiting
    • Blurred vision
    • Constipation
    • Dryness in mouth
    • Fatigue
    • Itching


  • Tell your doctor if you are allergic to it, other anti-seizure medications, tricyclic antidepressants, or if you have any other allergies before taking it. Inactive ingredients (such as sorbitol in the suspension) in this product may cause allergic reactions or other problems.
  • Tell your doctor or pharmacist about your medical history, especially if you have: decreased bone marrow function, blood disorders, glaucoma, heart disease, kidney disease, liver disease, mental/mood disorders, or mineral imbalances.
  • This medication may cause dizziness or drowsiness. Alcohol can cause dizziness or drowsiness. Do not drive, operate machinery, or engage in any activity that requires safety.
  • Sugar may be present in the chewable tablets or suspension. If you have diabetes or other condition that requires you to limit or avoid sugar in your diet, proceed with caution. Inquire with your doctor or pharmacist about the safe use of this product.
  • Older adults might be more sensitive to the drug’s side effects, such as confusion, unsteadiness, or irregular heartbeat. Confusion and shakiness can heighten the risk of falling. Older adults are also more likely to develop a mineral imbalance, especially if they are also taking water pills.
  • This medication should not be used during pregnancy. It can harm an unborn child. However, because untreated seizures are a serious condition that can harm both a pregnant woman and her unborn child, do not stop taking this medication unless your doctor tells you to. If you are planning for a pregnancy, discuss the benefits and risks of using this medication during pregnancy with your doctor as soon as possible. Prenatal care, including tests for birth defects, is recommended if you are pregnant. Because birth control pills, patches, implants, and injections may not work when combined with this medication, consult your doctor about alternative methods of birth control.
  • This might pass through breastmilk, before breastfeeding consult your doctor.
  • Interactions

  • Some products that interact with this drug are azole antifungals, orlistat. Taking MAO inhibitors with this medication may cause a serious drug interaction. Avoid taking MAO inhibitors along with this medication. Other medications can cause the removal of carbamazepine from your body, which may affect how it works. Examples include macrolide antibiotics, rifamycins.
  • Missed Dose

  • It is necessary to take each dose of this medication on time. If you forget a dose, contact your doctor or pharmacist as soon as possible to arrange for a new dosing schedule. Do not double the dose.
  • Overdose

  • If someone has taken an overdose of this medicine and has serious symptoms such as trouble breathing, seek medical advice immediately. Never take more doses than what is prescribed to you by your doctor.
  • Storage

  • Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Tegretol vs Gabapentin

    Tegretol Gabapentin
    This is an anti-epileptic drug that is used to treat epilepsy. Gabapentin is an anticonvulsant and anti-epileptic medication. It has an effect on the chemicals and nerves in the body that cause seizures and some types of pain.
    It is used primarily for the treatment of epilepsy and neuropathic pain. Gabapentin is used in conjunction with other medications to treat partial seizures in adults and children over the age of three.
    Tegretol 200 is also used for treating bipolar disorder.

    Gabapentin is also used to treat neuropathic pain (nerve pain) in adults caused by the herpes virus or shingles (herpes zoster).

    Frequently Asked Questions:

    It is a mood stabilizer. It is approved for the treatment of bipolar 1 disorder (also known as manic depression), as well as epilepsy and trigeminal neuralgia.

    Carbamazepine is known to cause euphoria as a side effect. As a result, it lends itself to abuse, particularly in the adolescent population.

    The most common side effects of Tegretol, especially when first starting it, are dizziness, drowsiness, unsteadiness, nausea, and vomiting. 1 Consult your doctor if these side effects persist or are bothersome.

    Memory issues may be more common with older anti-seizure medications such as Phenobarbital or Tegretol. One exception is that some people who take Topamax have difficulty concentrating and paying attention, which can impair memory.

    This medication is used to treat anxiety symptoms. It has an effect on the brain by reducing abnormal electrical activity. It is used to treat mental health issues such as depression, anxiety, and post-traumatic stress disorder (PTSD).

    Tegretol is a seizure medication. It reduces the nerve impulses that cause seizures and pain. Tegretol is used for treating certain types of seizures (partial, tonic-clonic, mixed). Tegretol is also used to treat nerve pain, such as trigeminal and glossopharyngeal neuralgia.

    It functions by regulating electrical activity in the brain and nerves. Carbamazepine works to treat epilepsy by preventing electrical signals from accumulating in the brain’s nerve cells. It also reduces the release of glutamate, a chemical (neurotransmitter). Seizures can occur if you consume too much glutamate.

    It is also beneficial in the treatment of chronic neuropathic pain. The tablets are available in 100 mg and large sizes. The maximum recommended dose is 600 mg taken twice daily (morning and near bedtime). The final dose will depend on how well the medication works for you and your tolerance to the medication.

    Your Complete Guide to Trigeminal Neuralgia; A. M. Kaufmann & M. Patel, CCND Winnipeg

    Your Complete Guide to Trigeminal Neuralgia; A. M. Kaufmann & M. Patel,
    CCND Winnipeg

    Part Two: Treatment of Trigeminal Neuralgia

    II.  MedicationsA.
         Today, trigeminal neuralgia
    is usually treated with drugs called anti-convulsants, which include carbamazepine
    (Tegretol), phenytoin (Dilantin), oxycarbazepine
    (Trileptal), and gabapentin
    (Neurontin). Phenytoin was first introduced in 1942,
    and in 1962 carbamazepine became the most commonly
    used drug. Baclophen (Lioresal) may add to the effectiveness of these drugs.
    Recently, Neurontin, (gabapentin) has been widely used
    because of reduced side effects, although is more expensive and somewhat less
    effective then Tegretol. The anti-convulsants are
    thought to reduce TN attacks by decreasing the hyperactivity of the trigeminal
    nerve nucleus in the brain stem.

         Treatment is usually initiated with one drug, such
    as Tegretol or Neurontin.
    The dose is increased as needed and tolerated. If any single drug proves ineffective,
    alternative drugs may be tried alone or in combination with other drugs. Medical
    therapy is initially effective for most patients with TN. Unfortunately, about
    half of TN sufferers eventually become dissatisfied with medical therapy, because
    of incomplete control of pain or drug-related side effects that are almost always
    experienced. Surgical treatments are then considered.

    compression of the trigeminal nerve root entry zone leads to hyperactivity
    of the trigeminal nerve nucleus.
    therapy aims to reduce hyperactivity of the trigeminal nerve nucleus,
    thereby reducing attacks of TN pain.

    Carbamazepine (Tegretol)

         Almost all typical
    TN sufferers experience significant pain relief with carbamazepine. The
    starting daily dose is low, (one to two pills a day), which is gradually increased
    until the pain is completely alleviated or side effects occur. Good relief of
    pain may be achieved at low doses, but the usual effective dose ranges from
    600 to 1600 mg divided in three or four doses per day. Even higher doses may
    be required during severe attacks of pain. Once relief of the pain has been
    achieved, the same dose is usually continued for at least two weeks before trying
    to reduce to a minimal dosage that provides pain relief. As with all TN medications,
    Tegretol may gradually be decreased during periods of remission.

         Several dose-related
    side effects are often experienced including drowsiness, mental confusion, dizziness,
    nystagmus (rapid movements of the eye), ataxia (decreased coordination), diplopia
    (double vision), nausea, and anorexia (loss of appetite). If side effects are
    severe, the daily dose of carbamazepine may be decreased for 1 to 3 days, before
    trying to increase the daily dose again.

         There are also rare but serious reactions to carbamazepine
    that are not dose related. These include an allergic skin rash that may form
    any time after the medication is started. Two to six percent of sufferers who
    take carbamazepine develop blood disorders including leukopenia or agranulocytosis
    (drop in the number of white blood cells), or aplastic anemia (when the bone
    marrow stops producing blood cells) . Other rare complications include liver toxicity, water intoxication (retention of water), hyponatremia (low sodium in the blood), congestive
    heart failure, visual hallucinations and disorders of taste or sexual function.
    Due to these complications, blood tests are usually conducted before carbamazepine
    is started, and repeated intermittently. The administration of carbamazepine
    should be discontinued if the white blood cell counts become abnormally low.
    A physician should be notified immediately and blood tests conducted if one
    experiences a fever, sore throat, stomatitis (painful infection of the mouth),
    easy bruising, or petechiae (tiny red spots on the skin).

    is a new form of Tegretol® that may involve fewer side effects and risks
    of toxicity, but must be taken in higher doses to provide adequate pain control.


    Trileptal (Oxycarbazepine)

    or oxycarbemazepine, is a form of Tegretol® that is becoming more widely
    prescribed for a variety of conditions. It has recently been found to be effective
    for some patients with trigeminal neuralgia. Like Tegretol®, it is an anti-seizure
    drug, but the side effects are less severe and less frequently experienced.

    The dose usually begins at 300 mg
    twice a day and is gradually increased to achieve pain control. The maximum
    dose is 2400-3000 mg per day. Common side effects are nausea, vomiting, dizziness,
    fatigue and tremors. Less frequent symptoms are rash, respiratory infections,
    double vision, and changes in electrolytes in blood. If you have had an allergic
    reaction to Tegretol® (carbemazepine), then you should not try Trileptal.
    As with other anti-seizure medications, increasing and decreasing the dose should
    be gradual.


    Phenytoin (Dilantin)

    relieves tic pain in over half of TN sufferers
    at doses of 300 to 500 mg, divided into three doses per day.Phenytoin may also
    be administered intravenously to treat severe exacerbations of TN. The maximum
    dose depends upon the severity of the side effects that are experienced with
    the drug. These dose-dependant side effects include nystagmus (rapid movements
    of the eye), ataxia (decreased coordination), dysarthria (speech difficulty),
    ophthalmoplegia (paralysis of eye movements) as well as drowsiness and mental
    confusion. Other effects of the medication may include gingival hyperplasia
    (enlargement of the gums in the mouth) and hypertrichosis (excessive hair growth).
    Rare but serious complications may occur, including allergic skin rashes, liver
    damage and blood disorders.

    E. Baclophen (Lioresal)

    is not as effective as carbamazepine or phenytoin for TN, but may be used in
    combination with these medications. The starting dose of baclophen is usually
    5 mg two or three times a day, and may be gradually increased. The usual dosage
    taken for complete pain relief is between 50 and 60 mg per day. Baclophen has
    a short duration of function so sufferers with severe TN may need to take doses
    every 3 to 4 hours.

    most common side effects associated with baclophen include drowsiness, dizziness,
    nausea and leg weakness. The incidence of these side effects is reduced by starting
    with a low dose of baclophen that is gradually increased. However, approximately
    one tenth of sufferers cannot tolerate baclophen. A rare complication is a confusional
    state that appears shortly after baclophen is started, but this resolves quickly
    when therapy is stopped. Baclophen should not be discontinued abruptly after
    prolonged use because hallucinations or seizures may occur. If these withdrawal
    symptoms do occur, the previous dose of baclophen is usually re-instituted and
    then gradually reduced.

    F. Gabapentin (Neurontin)

    is an anti-epileptic drug that is structurally related to the neurotransmitter
    GABA. This drug is almost as effective as carbamazepine
    but involves fewer side effects.The
    starting dose is usually 300mg three times a day and this is increased to a
    maximal dose. The most common adverse reactions include somnolence (sleepiness),
    ataxia (decreased coordination), fatigue, and nystagmus (rapid movements of
    the eye). There is no known interaction with Tegretol
    or Dilantin, permitting usage of these drugs in combination
    with Neurontin. As with all of these drugs, rapid discontinuation should be
    avoided as severe withdrawal reactions may occur.


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    Trigeminal Neuralgia
    Web-Site at the Centre for
    Cranial Nerve Disorders

    M. Kaufmann & M. Patel
    Centre for Cranial Nerve Disorders
    Winnipeg, Manitoba, Canada
    © 2001

    Prepared by A.
    M. Kaufmann
    & M.

    © 2001 Centre for Cranial Nerve Disorders, Winnipeg, University of Manitoba,
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    Tegretol (Carbamazepine) for Bipolar Disorder

    What is Tegretol?

    Tegretol is a medication known as an anticonvulsant that is used to treat the manic symptoms of bipolar disorder. It is also used to treat seizures and nerve pain.

    When did the U.S. Food and Drug Administration (FDA) approve the medication?

    Tegretol was first approved by the FDA in 1968.

    Is there a generic version of Tegretol?

    Yes, the generic version is known as carbamazepine and is sold in the U.S.

    Are there any major differences between Tegretol and other medications used to treat bipolar disorder?

    Tegretol belongs to the class of medications known as anticonvulsants. Anticonvulsants are sometimes taken to treat or prevent the manic episodes associated with bipolar disorder. Tegretol may be prescribed alone or in combination with other medications to treat symptoms.

    What warning information do I need to know about Tegretol?

    Tegretol may cause a life-threatening allergic reaction known as Stevens-Johnson Syndrome or toxic epidermal necrolysis. This can cause damage to your internal organs or skin. The risk factor is genetic, with people of Asian ancestry being at higher risk. Talk to your doctor about getting genetic testing to evaluate the risk of taking Tegretol. Tegretol can also decrease the number of blood cells in the body, so talk to your doctor if you already have a low number or are taking other medications that increase this risk.

    Article continues below

    Concerned about Bipolar Disorder?

    Take our 2-minute Bipolar quiz to see if you or a loved one may benefit from further diagnosis and treatment.

    Take Bipolar Quiz

    Can children take Tegretol?

    Children over the age of 6 can be prescribed Tegretol for seizures. Talk to your doctor about the risks and benefits and potential side effects to monitor.

    Are there potential interaction issues for people taking Tegretol and any other drugs?

    There are hundreds of drugs which are known to interact with Tegretol in major, moderate, or mild ways, so let your doctor know what other medications you are taking before you begin taking the medication. Some of these might include medication for mental illness such as depression or anxiety, antifungals, seizure medications, HIV protease inhibitors, malaria medications, sleeping medications, and any vitamins or over the counter prescriptions you might be taking. Tegretol may also decrease the effectiveness of hormonal contraceptives.

    Are there any other medical conditions that would make someone ineligible for Tegretol therapy?

    Talk to your doctor about other medical conditions before you take Tegretol, such as glaucoma, heart disease, kidney disease, thyroid or liver disease, or a history of psychosis. Also tell your doctor if you have a history of low blood cell count.

    What is the typical dose that would be prescribed to someone taking Tegretol?

    Dosage will vary depending on the age of the patient and the condition being treated.

    What do I do if I miss a dose?

    Take the dose of Tegretol when you remember, but skip the missed dose if it is almost time for your next dose. You should never take extra doses of the medication to make up for missed doses.

    What side effects can Tegretol cause?

    Common side effects can include:
    • nausea
    • dry mouth
    • constipation
    • dizziness
    • drowsiness
    • mild rash

    It also is recommended that you wait to drive or operate machinery until you know how the medication affects you and to avoid alcohol and illegal drugs while on the medication, as they can worsen adverse effects. Report major side effects to your doctor immediately, which can include swelling, shortness of breath, skin reaction, and fever. Report side effects to the FDA at 1-800-FDA-1088 or online.

    What are the potential psychological side effects of taking Tegretol?

    Anticonvulsant medications sometimes cause suicidal thoughts and behaviors in a small percentage of people who take the medication. Seek medical help if you experience these thoughts or other changes in your behavior or mood.

    What are the potential long-term effects of taking Tegretol?

    Tegretol can cause lower blood counts and lower sodium levels. Your doctor may want to monitor these periodically while you’re taking the medication.

    Is it safe for a woman who is pregnant, about to become pregnant, or nursing to take Tegretol?

    Tegretol can cause birth defects and fetal harm when taken during pregnancy. The drug can be transferred via breast milk and potentially harm a baby. Therefore, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing before you take Tegretol.

    Can symptoms occur if Tegretol is discontinued?

    It’s important not to discontinue use of the drug before talking with your doctor. Withdrawal symptoms of Tegretol can include sleep problems, increased anxiety, numbness in limbs, joint pain, shaking, and the return of manic or depressive symptoms.

    What should I do if I overdose on Tegretol?

    An overdose of Tegretol could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include abnormal or uncontrollable movements, restlessness, seizures, loss of balance, dizziness, drowsiness, blurred vision, slower or irregular breathing, rapid heartbeat, nausea, vomiting, trouble urinating, and unconsciousness.

    Is Tegretol habit-forming?

    Tegretol has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur.

    How much does Tegretol cost?

    According to goodrx.com, 60 tables of 200 mg generic carbamazepine cost approximately $65. 60 tablets of 200 mg Tegretol cost approximately $150.

    Are there any disadvantages to Tegretol?

    The biggest disadvantages of Tegretol are potential side effects which include severe allergic reaction and decreased blood cell count. Pregnant women are also typically advised not to take the medication due to the risk of birth defects.

    DISCLAIMER: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other healthcare providers. This article mentions drugs that were FDA-approved and available at the time of publication and may not include all possible drug interactions or all FDA warnings or alerts. The author of this page explicitly does not endorse this drug or any specific treatment method. If you have health questions or concerns about interactions, please check with your physician or go to the FDA site for a comprehensive list of warnings.

    Article Sources

    FDA – Tegretol
    NIH – Carbamazepine

    Last Updated: Nov 25, 2018

    Carbamazepine side effects & info on epilepsy drug – Patient

    About carbamazepine

    Type of medicine An antiepileptic medicine
    Used for Epilepsy; trigeminal neuralgia; bipolar disorder
    Also called Tegretol®; Curatil®
    Available as Tablets, oral liquid medicine, suppositories and prolonged-release tablets

    If you have epilepsy, it means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different functions of your body, so the symptoms that occur during a seizure will depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, and consciousness, or a combination of these. The seizures can be prevented in most people by suitable antiepileptic medication. Carbamazepine is a commonly used medicine. It works by stabilising the electrical activity of your brain, which prevents the seizures from occurring.

    Carbamazepine is also prescribed as a treatment for severe burning or stabbing pains in the face (called trigeminal neuralgia), and occasionally as part of the treatment for bipolar disorder (sometimes called manic depression). This is because it can modify some types of pain, and control some mood disorders. If you have been given carbamazepine for these (or any other reasons), ask your doctor if you have questions about your treatment.

    Before taking carbamazepine

    Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking carbamazepine it is important that your doctor knows:

    • If you are pregnant, trying for a baby or breastfeeding.
    • If you have any problems with the way your kidneys work, or with the way your liver works.
    • If you have any heart condition.
    • If you have increased pressure in your eyes, a condition known as glaucoma.
    • If you have ever had any problems affecting your bone marrow.
    • If you have a rare inherited blood disorder called porphyria.
    • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
    • If you have ever had an allergic reaction to a medicine.

    How to take carbamazepine

    • Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about carbamazepine and will provide you with a full list of the side-effects which you may experience from taking it.
    • Take carbamazepine exactly as your doctor tells you to. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. If you are taking it for epilepsy, it is likely you will be asked to take one or two doses every day. Doses for children are tailored to their age and weight. If you have been prescribed it for another reason, you could be asked to take a dose three, or even four, times a day. Your dose will be printed on the label of the pack to remind you about what the doctor said to you.
    • Try to take your doses of carbamazepine at the same times each day. Having a routine will help you to remember to take your doses regularly. Swallow the tablet with a drink of water. You can take most preparations of carbamazepine either before or after meals. If, however, you have been supplied with chewable tablets, you should take these during a mealtime.
    • If you have been given carbamazepine prolonged-release tablets you must swallow the tablet whole – do not chew or crush the tablet.
    • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

    Getting the most from your treatment

    • When you first start a new treatment for epilepsy there may be a change in the number or type of seizures you experience. Your doctor will advise you about this.
    • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You may need to have blood tests from time to time.
    • Different formulations and brands of carbamazepine can act in a slightly different way in your body. Because of this, it is important that you continue to take tablets from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
    • If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines interfere with carbamazepine, and carbamazepine can also alter the way other medicines work.
    • Ask your doctor for advice before drinking alcohol while you are on carbamazepine. Your doctor may recommend you do not drink alcohol because it increases the risk of side-effects.
    • People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to start driving again. This will usually be after a year free of seizures.
    • Carbamazepine may harm an unborn child so you must avoid getting pregnant. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist before you become pregnant.
    • While you are being treated for epilepsy there is a small risk that you may develop mood changes, distressing thoughts and feelings about suicide. If this happens, you must tell your doctor about it straightaway.
    • You need to take carbamazepine regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.

    Can carbamazepine cause problems?

    Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with carbamazepine. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. Many of the side-effects can occur when first starting carbamazepine, but should settle down as your body adjusts to the new medicine. Speak with your doctor if they continue or become troublesome.

    Common carbamazepine side-effects What can I do if I experience this?
    Feeling dizzy, sleepy, or tired; blurred or double vision Do not drive and do not use tools or machines
    Feeling sick (nausea) or being sick (vomiting) Stick to simple meals – avoid rich and spicy food
    Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
    Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets
    Feeling unsteady, swollen feet or ankles, itchy skin rash, increased risk of infection If any of these become troublesome, speak with your doctor for advice

    Important: your doctor will discuss with you the possibility that carbamazepine can cause liver, blood and skin disorders. Although these occur less commonly than the side-effects listed above, it is important that you contact your doctor straightaway if you experience any of the following symptoms:

    • A high temperature (fever), sore throat or swollen glands.
    • A severe skin rash.
    • Mouth ulcers.
    • Unexplained bruising or bleeding.

    If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

    How to store carbamazepine

    • Keep all medicines out of the reach and sight of children.
    • Store in a cool, dry place, away from direct heat and light.

    Important information about all medicines

    Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

    This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

    If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

    Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

    If you have any questions about this medicine ask your pharmacist.

    Tegretol Retard – (Carbamazepine) | MyTeleHealth

    Why have I been prescribed Tegretol?

    • The active ingredient of Tegretol is carbamazepine. 
    • Carbamazepine is one of a group of medicines called anticonvulsants. 
    • It is used to treat epilepsy. 
    • Carbamazepine is also used to treat a painful condition of the face (trigeminal neuralgia) and also may be used to help prevent mood swings.

    How does it work?

    It works by decreasing the excitability of nerve cells and preventing them firing inappropriately.

    When and how do I take it?

    Tegretol is always (except possibly on the first day) given in divided daily doses, i.e. 2 to 4 times a day, depending on your medical condition.

    • Take Tegretol during or after a meal.
    • Swallow the tablets with some liquid; if necessary, the tablets may be broken in half along the line.

    Do not drink grapefruit juice or eat grapefruit since this can increase the effect of Tegretol. Other juices, like orange juice or apple juice, do not have this effect.

    What’s the dose?

    Treatment of epilepsy is usually started at 100 to 200 mg once or twice a day in adults. The dosage is then gradually increased to 800 to 1200mg a day ( i.e. 40–60 mls oral suspension), divided in 2 or 3 intakes.

    Treatment in children is usually started at 100 to 200 mg day (based on 10 to 20 mg/kg body weight daily) and kept at 400 to 800 mg a day. Adolescents may receive between 600 and 1000 mg a day.

    Tegretol is not suitable for children under 5 years.

    For trigeminal neuralgia the starting dosage of 200 to 400 mg a day is slowly raised until there is no pain usually 200 mg 3 to 4 times a day.

    For elderly patients a lower starting dose, 100 mg twice a day, is recommended.

    For mood disorders the usual dosage is 400 to 600 mg a day.

    For alcohol withdrawal symptoms the usual dosage is 600–800 mg a day.

    Could it interact with other tablets?

    If you are already taking any of the following medicines, tell your doctor. It may affect your dose of Tegretol or increase the risk of side effects:

    • Phenobarbital, Phenytoin, Primidone, Valproic Acid, Felbamate, Ethosuximide, Tiagabine, Lamotrigine, Flunarizine (other antiepileptics)
    • Antibiotics include Rifampicin, Josamycin, Clarithromycin. Troleandromycin, Erythromycin, Isoniazid, Doxycycline
    • Itraconazole, Ketoconazole, Voriconazole, Fluconazole, Caspofungin (treatment of fungal infections)
    • Ritonavir, Indinavir (anti-viral medicine)
    • Praziquantel (to treat worm infections
    • medicine for heart problems e.g. Verapamil, Digoxin, Diltiazem, Quinidine, Hydroquinidine, or for high blood pressure eg. Dihydropyridines (such as Felodipine), Propranolol
    • Acetazolamide (to treat glaucoma)
    • Hydrochlorothiazide, Furosemide (diuretics or ‘water tablets’)
    • Dextropropoxyphene/Propoxyphene, Methadone, Tramadol, Fentanyl, Paracetamol, Phenazone (painkillers)
    • Midazolam (sedative)
    • Fluoxetine, Viloxazine, Desipramine, Imipramine, Fluvoxamine, Trazadone, Nortriptyline, Amitriptyline, Clomipramine (antidepressants)
    • Clonazepam, Ethosuximide, Alprazolam, Clobazam (medicines for anxiety)
    • Haloperidol, Bromperidol, Lithium, Olanzapine, Quetiapine, Risperidone, Clozapine (to treat mental illness)
    • Nicotinamide in high doses (vitamin of the B group)
    • Cimetidine (for the treatment of ulcers)
    • Theophylline (for asthma)
    • Corticosteroids (eg. Prednisolone, Dexamethasone)
    • Ciclosporin, Tacrolimus, Sirolimus (immunosuppressants)
    • Cisplatin, Doxorubicin, Procarbazine (anti-cancer medicine)
    • Anticoagulant drugs such as Warfarin, Phenprocoumon and Dicumarol
    • Muscle relaxants (e.g. Pancuronium)
    • Isotretinoin (to treat acne)
    • Danazol (treatment for endometriosis)
    • contraceptive “pill”: It is advised to use another form of contraception.
    • Other medicines containing oestrogens/progestogens, HRT treatment
    • Terfenadine, Loratadine (for allergies)
    • Bupropion (anti-smoking treatment)
    • Methylphenidate (to treat ADH disorder)
    • The herbal remedy St. Johns Wort (Hypericum perforatum) should not be taken at the same time as this medicine. If you already take St. Johns Wort, consult your doctor before stopping the St. John’s Wort preparations.

    Herbal products should also only be taken after talking with your doctor.

    What are the possible risks or side-effects?

    Like most medicines, Tegretol can have side effects. Side effects aremore common at the start of treatment, but usually disappear after a few days or when the dose is adjusted to be right for you. 

    Common effects seen in less than 1 in 10 patients but more than 1 in 100, include: 

    • feeling dizzy
    • feeling tired or drowsy
    • suffering from skin rashes and a loss of co-ordination

    Tell your doctor straight away if you:

    • notice a skin rash or a severe skin reaction
    • suffer from a persistent sore throat, fever or both
    • feel feverish
    • suffer from mouth ulcers or notice unusual bruising or bleeding of your skin
    • get a throbbing headache
    • stiff neck and become sensitive to bright light
    • have difficulty breathing
    • have a combination of symptoms including painful joints or muscles and a rash

    These are rare effects, seen in less than 1 in 1000 patients but more than 1 in 10,000.

    Very common side effects (affecting more than or equal to 1 in 10 patients): 

    Common side effects (affecting less than 1 in 10 patients):

    • swelling of the ankles, feet or lower legs (oedema)
    • changes in behaviour
    • confusion 
    • weakness
    • increase in seizures (fits)
    • blurred vision
    • double vision
    • itching with redness and swelling of the eye (conjunctivis)
    • feeling pressure/pain in the eye (signs of increased pressure in the eye)
    • trembling
    • uncontrolled body movements
    • muscle spasms
    • uncontrolled eye movements

    Uncommon effects, seen in less than 1 in 100 patients but more than 1 in 1000, include: 

    Can I drink Alcohol while taking it?

    This medicine interacts with alcohol and concomitant use should be avoided.

    What if I’m pregnant/breastfeeding?

    • If you are planning to become pregnant, talk to your doctor first.
    • If you are pregnant and need to take an anticonvulsant, you are likely to be taking only one anticonvulsant. 
    • Your doctor will monitor you and your unborn child closely. 
    • Breast feeding while taking Tegretol is not recommended. If you do breast feed and you take Tegretol, tell your doctor straight away if your child becomes very drowsy or is slow to put on weight.

    If you have any more questions please ask your Pharmacist.

    Remember to keep all medicines out of reach of children
    Please Note: 
    We have made every effort to ensure that the content of this information sheet is correct at time of publish, but remember that information about drugs may change. This sheet does not list all the uses and side-effects associated with this drug. For full details please see the drug information leaflet which comes with your medicine. Your doctor will assess your medical circumstances and draw your attention to any information or side-effects which may be relevant in your particular case.









    Carbamazepine | Health Navigator NZ

    Carbamazepine is used to treat epilepsy, control some mood disorders such as bipolar disorder and for some types of pain such as nerve pain. Find out how to take it safely and possible side effects. Carbamazepine is also called Tegretol.

    Type of medicine Also called

    • Belongs to a group of medicines known as anti-epileptic medication (to prevent seizures), but it has many other uses.

    What is carbamazepine?

    Carbamazepine has many different uses including the treatment of epilepsy by preventing seizures, the control of some mood disorders such as bipolar disorder and the treatment of some types of nerve pain involving the face, head and neck (trigeminal neuralgia). Carbamazepine blocks certain kinds of nerve activity. In New Zealand, carbamazepine is available as:

    • Tegretol liquid (syrup) 100 mg in 5 mL
    • Tegretol 200 mg and 400 mg tablets (white tablets)
    • Tegretol CR 200 mg tablets (beige-orange tablets)
    • Tegretol CR 400 mg tablets (brown-orange tablets)


    • The dose of carbamazepine is different for different people.
    • Your doctor will start you on a low dose, and increase your dose slowly over a few weeks. This will help to reduce the risk of side effects.
    • Always take your carbamazepine exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it, and any special instructions.

    How to take carbamazepine

    • Carbamazepine can be taken with food if you have stomach upset.
    • Take your doses at the same times each day, to help you to remember to take it.
    • Carbamazepine is available as a liquid or as tablets.

    Formulation How to take it
    Tegretol liquid

    • Measure the right amount using an oral syringe or medicine spoon.
      You can get these from your pharmacy.
    • Do not use a kitchen spoon as it will not give you the right amount.
      Read more: Tips on how to give medicines to babies and children.
    • The liquid is usually taken 3 or 4 times a day.
    Tegretol tablets

    • You can swallow these tablets with a glass of water, juice or milk.
    • If you have swallowing problems, you can put the tablet in a small amount of water (5 to 10 mL) so it can dissolve. This may take a few minutes, then gently stir or shake it. Swallow all of the solution straight away. You could also ask for the liquid instead but the dose and times may need to be adjusted.
    • These tablets are usually taken 2 or 3 times a day.
    Tegretol CR tablets

    • These tablets can be halved but do not crush or chew them, this could cause side effects.
    • Take these tablets with a glass of water, juice or milk.
    • These tablets are usually taken twice a day.
    • Missed dose: If you forget to take your dose, take it as soon as you remember that day. But, if it is nearly time for your next dose (within 2 to 3 hours), just take the next dose at the right time. Do not take double the dose.
    • Keep taking carbamazepine every day. It may take a few weeks before you experience the full benefits of carbamazepine. For people with nerve pain, carbamazepine can provide relief within a few days. Do not stop taking carbamazepine suddenly; speak to your doctor or nurse before stopping.  See tips to help you remember to take your medicines regularly.

    Precautions – before starting carbamazepine

    • Are you pregnant or trying for a baby?
    • Do you have problems with the way your kidneys or liver works?
    • Do you have a heart condition?
    • Do you have any problems affecting your bone marrow?

    If so, it’s important that you tell your doctor before you start carbamazepine. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

    Side effects

    Like all medicines, carbamazepine can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.

    Side effects What should I do?

    • Feeling sleepy, drowsy or tired
    • Feeling dizzy, or faint

    • This is common when starting carbamazepine and may last a few hours after taking your dose
    • Be careful when driving or using tools until you know how this medicine affects you
    • Limit or avoid alcohol
    • Tell your doctor if troublesome, you may need to adjust your dose.

    • Problems with your eyesight – blurred vision or seeing double   

    • Be careful when driving or using tools 
    • Tell your doctor if troublesome

    • Feeling sick (nausea)
    • Stomach upset

    • Try taking carbamazepine with food
    • Tell your doctor if troublesome

    • Tell your doctor if troublesome

    • Low mood, suicidal thoughts — thoughts of harming yourself

    • Easy bruising, feeling tired, looking pale, getting sick often

    •  Tell to your doctor as you may need a blood test.

    • Signs of an allergic reaction such as skin rash, hives, itches, swelling of the face, mouth or lips, trouble breathing 

    • Tell your doctor immediately or ring HealthLine 0800 611 116


    • Carbamazepine interacts with many medications and herbal supplements, especially anti-viral medicines, anti-clotting medicines such as warfarin and oral contraceptives. Always check with your doctor or pharmacist before starting carbamazepine or before starting any new medicines.
    • It may also interact with medicines that are available without a prescription such as cough, cold and flu medication, or anti-allergy medication. Check with your pharmacist before taking any new medicines.

    Learn more

    Tegretol Medsafe Consumer Information Sheet
    For adults: Carbamazepine New Zealand Formulary Patient Information
    For children: Carbamazepine New Zealand Formulary for Children


    1. Carbamazepine New Zealand Formulary Patient Information
    2. Carbamazepine New Zealand Formulary for Children
    3. Tegretol Medsafe Data sheet
    4. Managing patients with neuropathic pain BPAC, May 2016
    5. Bipolar disorder: identifying and supporting patients in primary care BPAC, July 2014

    Tegretol instructions for use: indications, contraindications, side effects – description of Tegretol tab. 200 mg: 50 pcs. (34562)

    💊 Composition of the preparation Tegretol ®

    ✅ Application of the drug Tegretol ®


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    Description of the active components of the drug

    Tegretol ®
    (Tegretol ® )

    The scientific information provided is generalized and cannot be used to make
    decisions about the possibility of using a particular drug.

    Update date: 2020.04.

    Marketing Authorization Holder:

    ATX code:



    Dosage form

    Tegretol ®

    Tab.200 mg: 50 pcs.

    reg. No .: P N012130 / 01
    from 18.11.11
    – Indefinitely

    Re-registration date: 06/20/19

    Release form, packaging and composition


    Tablets are white, round, flat, chamfered, marked “CG” on one side and “G / K” on the other, and there is a risk.

    1 tab.
    carbamazepine 200 mg

    Excipients : microcrystalline cellulose, low-substituted sodium carmellose, magnesium stearate, anhydrous colloidal silicon dioxide.

    10 pcs. – blisters (5) – cardboard packs.

    Pharmacological action

    Antiepileptic agent, derivative of tricyclic iminostilbene.It is believed that the anticonvulsant effect is associated with a decrease in the ability of neurons to maintain a high frequency of development of repeated action potentials through inactivation of sodium channels. In addition, inhibition of the release of neurotransmitters by blocking presynaptic sodium channels and the development of action potentials, which in turn reduces synaptic transmission, seems to be important.

    Has a moderate antimanic, antipsychotic effect, as well as an analgesic effect for neurogenic pain.Mechanisms of action possibly involve GABA receptors, which may be associated with calcium channels; also, apparently, the effect of carbamazepine on the systems of modulators of neurotransmission.

    The antidiuretic effect of carbamazepine may be associated with a hypothalamic effect on osmoreceptors, which is mediated through the secretion of ADH, and also due to a direct effect on the renal tubules.


    After oral administration, carbamazepine is almost completely absorbed from the gastrointestinal tract.Plasma protein binding is 75%. It is an inducer of liver enzymes and stimulates its own metabolism.

    T 1/2 is 12-29 hours. 70% is excreted in the urine (in the form of inactive metabolites) and 30% in the feces.

    Indications of the active substances of the drug



    Epilepsy: large, focal, mixed (including large and focal) epileptic seizures.Pain syndrome of predominantly neurogenic genesis, incl. essential neuralgia of the trigeminal nerve, neuralgia of the trigeminal nerve in multiple sclerosis, essential glossopharyngeal neuralgia. Prevention of seizures in alcohol withdrawal syndrome. Affective and schizoaffective psychoses (as a means of prevention). Diabetic neuropathy with pain syndrome. Diabetes insipidus of central origin, polyuria and polydipsia of neurohormonal nature.

    Dosing regimen

    Method of application and dosage regimen of a particular drug depends on its form of release and other factors.The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

    Set individually. For oral administration for adults and adolescents 15 years of age and older, the initial dose is 100-400 mg. If necessary and taking into account the clinical effect, the dose is increased by no more than 200 mg / day with an interval of 1 week.The frequency of admission is 1-4 times / day. The maintenance dose is usually 600-1200 mg / day in divided doses. The duration of treatment depends on the indications, the effectiveness of treatment, the patient’s response to therapy.

    In children under 6 years of age, use 10-20 mg / kg / day in 2-3 divided doses; if necessary and taking into account tolerance, the dose is increased by no more than 100 mg / day with an interval of 1 week; the maintenance dose is usually 250-350 mg / day and does not exceed 400 mg / day. Children aged 6-12 years – 100 mg 2 times / day on the first day, then the dose is increased by 100 mg / day with an interval of 1 week.until the optimal effect is obtained; the maintenance dose is usually 400-800 mg / day.

    Maximum doses: for oral administration in adults and adolescents 15 years and older – 1.2 g / day, for children – 1 g / day.

    Side effects

    From the side of the central nervous system and peripheral nervous system: often – dizziness, ataxia, drowsiness; possible headache, diplopia, accommodation disturbances; rarely – involuntary movements, nystagmus; in some cases – oculomotor disorders, dysarthria, peripheral neuritis, paresthesias, muscle weakness, paresis symptoms, hallucinations, depression, fatigue, aggressive behavior, agitation, impaired consciousness, increased psychosis, taste disturbances, conjunctivitis, tinnitus, hyperacusis.

    From the digestive system: nausea, increased GGT, increased alkaline phosphatase activity, vomiting, dry mouth; rarely – increased activity of transaminases, jaundice, cholestatic hepatitis, diarrhea or constipation; in some cases – decreased appetite, abdominal pain, glossitis, stomatitis.

    From the side of the cardiovascular system: rarely – myocardial conduction disorders; in some cases – bradycardia, arrhythmias, AV block with syncope, collapse, heart failure, manifestations of coronary insufficiency, thrombophlebitis, thromboembolism.

    From the hematopoietic system: leukopenia, eosinophilia, thrombocytopenia; rarely – leukocytosis; in some cases – agranulocytosis, aplastic anemia, erythrocytic aplasia, megaloblastic anemia, reticulocytosis, hemolytic anemia, granulomatous hepatitis.

    From the side of metabolism: hyponatremia, fluid retention, edema, weight gain, decrease in plasma osmolality; in some cases – acute intermittent porphyria, folic acid deficiency; disorders of calcium metabolism, increased cholesterol and triglyceride levels.

    From the endocrine system: gynecomastia or galactorrhea; rarely – dysfunction of the thyroid gland.

    From the urinary system: rarely – renal dysfunction, interstitial nephritis and renal failure.

    On the part of the respiratory system: in some cases – dyspnea, pneumonitis or pneumonia.

    Allergic reactions: skin rash, itching; rarely – lymphadenopathy, fever, hepatosplenomegaly, arthralgia.

    Contraindications to use

    AV block, previous myelodepression, history of intermittent porphyria, concomitant use of MAO inhibitors and lithium preparations, hypersensitivity to carbamazepine.

    Use during pregnancy and lactation

    If it is necessary to use it during pregnancy (especially in the first trimester) and during lactation, the expected benefits of treatment for the mother and the risk for the fetus or child should be carefully weighed.In this case, carbamazepine is recommended to be used only as monotherapy in the minimum effective doses.

    Women of childbearing age are recommended to use non-hormonal contraception during treatment with carbamazepine.

    Application for violations of liver function

    Use with caution in severe liver dysfunction.

    Application for impaired renal function

    Use with caution in severe renal impairment.

    Use in children

    Use with caution in children.

    Use in elderly patients

    Use with caution in elderly patients.

    Special instructions

    Carbamazepine is not used for atypical or generalized small epileptic seizures, myoclonic or atonic epileptic seizures.Should not be used to relieve common pain; as a prophylactic agent during long periods of remission of trigeminal neuralgia.

    Use with caution in case of concomitant diseases of the cardiovascular system, severe impaired liver and / or kidney function, diabetes mellitus, increased intraocular pressure, with indications of a history of hematological reactions to the use of other drugs, hyponatremia, urinary retention, hypersensitivity to tricyclic antidepressants, with a history of indications of interruption of the course of treatment with carbamazepine, as well as children and elderly patients.

    Treatment should be carried out under the supervision of a physician. With long-term treatment, it is necessary to monitor the blood picture, the functional state of the liver and kidneys, the concentration of electrolytes in the blood plasma, and conduct an ophthalmological examination. Periodic determination of the level of carbamazepine in blood plasma is recommended to monitor the effectiveness and safety of treatment.

    At least 2 weeks before starting therapy with carbamazepine, treatment with MAO inhibitors should be discontinued.

    Avoid drinking alcohol during treatment.

    Influence on the ability to drive vehicles and mechanisms

    During treatment, you should refrain from engaging in potentially hazardous activities that require increased attention, speed of psychomotor reactions.

    Drug interactions

    With the simultaneous use of inhibitors of the isoenzyme CYP3A4, it is possible to increase the concentration of carbamazepine in the blood plasma.

    With the simultaneous use of inducers of the CYP3A4 isoenzyme system, it is possible to accelerate the metabolism of carbamazepine, decrease its concentration in blood plasma, and decrease the therapeutic effect.

    With the simultaneous use of carbamazepine stimulates the metabolism of anticoagulants, folic acid.

    With simultaneous use with valproic acid, it is possible to reduce the concentration of carbamazepine and a significant decrease in the concentration of valproic acid in the blood plasma.This increases the concentration of the carbamazepine metabolite, carbamazepine epoxide (probably due to inhibition of its conversion to carbamazepine-10,11-trans-diol), which also has anticonvulsant activity, so the effects of this interaction can be leveled, but more often side reactions occur – blurred vision, dizziness, vomiting, weakness, nystagmus. With the simultaneous use of valproic acid and carbamazepine, a hepatotoxic effect may develop (apparently due to the formation of a secondary metabolite of valproic acid, which has a hepatotoxic effect).

    With the simultaneous use of valpromide reduces the metabolism in the liver of carbamazepine and its metabolite carbamazepine-epoxide due to inhibition of the enzyme epoxide hydrolase. The specified metabolite has anticonvulsant activity, but with a significant increase in plasma concentration, it can have a toxic effect.

    When used simultaneously with verapamil, diltiazem, isoniazid, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazol, desipramine, nicotinamide (in adults, only in high doses), erythromycin, trolycin, trolycin with azoles (incl.including itraconazole, ketoconazole, fluconazole), terfenadine, loratadine may increase the concentration of carbamazepine in the blood plasma with the risk of side effects (dizziness, drowsiness, ataxia, diplopia).

    With simultaneous use with hexamidine, the anticonvulsant effect of carbamazepine is weakened; with hydrochlorothiazide, furosemide – a decrease in the sodium content in the blood is possible; with hormonal contraceptives – the weakening of the effect of contraceptives and the development of acyclic bleeding is possible.

    With simultaneous use with thyroid hormones, it is possible to increase the elimination of thyroid hormones; with clonazepam – an increase in the clearance of clonazepam and a decrease in the clearance of carbamazepine are possible; with lithium preparations – mutual enhancement of neurotoxic action is possible.

    With simultaneous use with primidone, it is possible to reduce the concentration of carbamazepine in the blood plasma. There are reports that primidone can increase the plasma concentration of a pharmacologically active metabolite, carbamazepine-10,11-epoxide.

    Simultaneous administration with ritonavir may increase the side effects of carbamazepine; with sertraline – a decrease in the concentration of sertraline is possible; with theophylline, rifampicin, cisplatin, doxorubicin – a decrease in the concentration of carbamazepine in the blood plasma is possible; with tetracycline – the effects of carbamazepine may be weakened.

    With simultaneous use with felbamate, a decrease in the concentration of carbamazepine in the blood plasma is possible, but an increase in the concentration of the active metabolite of carbamazepine-epoxide, while a decrease in the plasma concentration of felbamate is possible.

    With simultaneous use with phenytoin, phenobarbital, the concentration of carbamazepine in the blood plasma decreases. Mutual weakening of the anticonvulsant action is possible, and in rare cases – its enhancement.


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    Carbamazepine: Pediatric Medication | Memorial Sloan Kettering Cancer Center

    This document, provided by Lexicomp ® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

    Trade names: USA

    Carbatrol; Epitol; Equetro; TEGretol; TEGretol-XR

    Trade names: Canada

    APO-CarBAMazepine; DOM-CarBAMazepine; DOM-CarBAMazepine CR; Mazepine; PMS-CarBAMazepine; PMS-CarBAMazepine CR; PMS-CarBAMazepine-CR; SANDOZ CarBAMazepine CR; SANDOZ CarBAMazepine [DSC]; TARO-CarBAMazepine; TEGretol; TEGretol CR; TEVA-Carbamazepine


    • Cases of dangerous abnormalities in blood cell levels have occurred, such as aplastic anemia and a variant of low leukocyte counts.Tell your doctor right away if your child feels very tired or weak, has a fever, chills, shortness of breath, unexplained bruising and bleeding, or purple spots on the skin.
    • If the child has any signs of infection, such as fever, chills, flu-like symptoms, very bad sore throat, sore ear or sinuses, cough, increased or discolored sputum, pain when urinating mouth ulcers or non-healing wounds, see your child’s doctor immediately.
    • Possible severe skin reaction (Stevens-Johnson syndrome / toxic epidermal necrolysis). This can lead to serious and permanent health problems and sometimes death. Get medical help right away if your child has symptoms such as redness, skin swelling with blistering or scaling (with or without a fever), redness or irritation of the eyes, painful sores on the lining of the mouth, throat, nose, or eyes …
    • People with a particular gene (HLA-B * 1502) are more likely to have serious and sometimes fatal skin reactions associated with this drug. This gene is most common among Asians, including South Asian Indians. If you have any questions, consult your doctor.
    • People with a particular gene (HLA-A * 3101) may be more likely to have serious allergic reactions associated with this drug. Allergic reactions can lead to death.If you have any questions, consult your doctor.

    What is this drug used for?

    • Used to treat seizures.
    • It is used to treat pain syndrome caused by damage to the facial nerve.
    • This medication is used to treat bipolar disorder.
    • This drug can be given to children for other indications. Consult your doctor.

    What should I tell my doctor BEFORE my child takes this drug?

    • If your child is allergic to this drug, any of its ingredients, other drugs, foods, or substances.Tell your doctor about the allergy and how your child has it.
    • If your child has kidney disease.
    • If your child has any of the following: bone marrow disease or porphyria.
    • If your child’s body is unable to break down fructose, consult a doctor. Some of these drugs contain sorbitol.
    • If your child is taking any drugs (prescription or over-the-counter, natural drugs, and vitamins) that should not be taken with this drug — for example, some drugs for HIV, other infections, or seizures.There are many medicines that should not be taken at the same time as this medicine.
    • If your child has taken drugs for depression or some other medical condition in the past 14 days. These include isocarboxazid, phenelzine, and tranylcypromine. An episode of very high blood pressure may occur.

    This list of drugs and diseases that may be adversely associated with this drug is not exhaustive.

    Talk to your doctor or pharmacist about all medications your child is taking (prescription and over-the-counter, natural products, and vitamins) and any health concerns. You need to make sure that this drug is safe for your child’s illness and in combination with other drugs that he or she is already taking. You should not start, stop, or change the dosage of any drug your child is taking without talking to your doctor.

    What do I need to know or do while my child is taking this drug?

    • Tell all health care providers for your child that your child is taking this drug. These are your child’s doctors, nurses, pharmacists and dentists.
    • Perform blood tests as directed by your healthcare practitioner. Please consult your doctor.
    • Check your child’s eyesight as directed by your doctor.
    • This drug may interfere with some lab tests. Tell all healthcare professionals and laboratory staff providing your child’s healthcare that your child is taking this drug.
    • Alcohol may interact with this drug. Make sure your child does not drink alcohol.
    • Consult with your child’s doctor before using marijuana, other forms of cannabis, prescription or over-the-counter drugs that may slow down your child’s actions.
    • Consult a pediatrician if your child frequently drinks grapefruit juice or eats grapefruit.
    • Have your child avoid tasks or activities that require attention until you see how this drug is working for your child. This includes cycling, playing sports, or using items such as scissors, lawn mowers, electric scooters, toy cars, or motorized vehicles.
    • Do not suddenly stop giving this drug to your child without talking to your doctor. This can increase the risk of seizures. If your child needs this drug, stop taking this drug gradually, as directed by the doctor.
    • Consult a doctor if seizures change or worsen after starting this drug.

    If your child is or may be sexually active:

    • Some pregnancy tests may not give results when you take this drug.Consult your doctor.
    • The contraceptive effectiveness of birth control pills and other hormonal contraceptives may be reduced. Make sure your child is also using another form of birth control, such as a condom, while taking this drug.

    If your daughter is pregnant or breastfeeding:

    • If your daughter uses the drug during pregnancy, the drug may have a harmful effect on the fetus.If your daughter is pregnant or becomes pregnant while taking this drug, call her doctor right away.
    • Tell the doctor if your daughter is breastfeeding. You will need to be consulted about the possible risks to the child.

    What side effects should I report to my child’s healthcare provider right away?

    WARNING / CAUTION: Although rare, this drug can cause very serious and sometimes deadly side effects in some people.Call your child’s doctor right away or get medical attention if your child has any of the following signs or symptoms that could be associated with a very bad side effect:

    • Signs of an allergic reaction such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
    • Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confusion, weakness, seizures, balance problems.
    • Change of speech.
    • Hallucinations (a person sees or hears something that is not in reality).
    • Change in vision.
    • Difficulty walking.
    • Severe and sometimes deadly side effects have been reported in patients using drugs similar to this drug for seizures.If your child has swollen lymph nodes, fever, rash, chest pains, signs of kidney damage such as urinary retention or changes in urine output, signs of liver damage such as dark urine, feeling tired, or not feeling hungry , nausea or abdominal pain, light colored stools, vomiting, yellow skin or eyes, see a doctor immediately.
    • Like other drugs used to treat seizures, this drug in rare cases may increase the risk of suicidal ideation or behavior.This risk may be higher in people who have attempted suicide or have had suicidal thoughts in the past. See your doctor right away if you develop or worsen symptoms such as depression, nervousness, anxiety, irritability, panic attacks, or other mood or behavior disorders. In case of suicidal thoughts or attempted suicide, contact your doctor immediately.
    • Patients can develop a very serious and sometimes fatal complication called neuroleptic malignant syndrome.Call your child’s doctor right away if the child has a fever, muscle cramps or stiffness in the muscles, dizziness, very bad headache, confusion, changes in thinking, tachycardia, a feeling of irregular heartbeat, and profuse sweating.
    • A heart problem, such as heart failure and certain heart rhythm problems, has happened with this drug. Sometimes these heart problems have resulted in death.If your child has a fast, slow heartbeat, or an irregular heartbeat, severe dizziness or fainting, shortness of breath, weight gain, or swelling in the arms or legs, see your child’s healthcare provider right away.
    • A very severe reaction called angioedema has occurred with this drug. Sometimes this reaction can be life-threatening. Symptoms may include swelling of the hands, face, lips, eyelids, tongue, or throat, difficulty breathing or swallowing, or uncharacteristic hoarseness.Call your doctor right away if your child has any of these symptoms.

    What are some other side effects of this drug?

    Any drug can have side effects. However, many people have little or no side effects. Call your child’s doctor or get medical help if any of these or other side effects bothers your child or does not go away:

    • Feeling dizzy, sleepy, tired, or weak.
    • Nausea or vomiting.
    • Dry mouth.
    • Constipation.

    This list of potential side effects is not exhaustive. If you have any questions about side effects, talk to your child’s doctor. Talk to your child’s doctor about side effects.

    You can report side effects to the National Health Office.

    What is the best way to give this drug?

    Give this drug to your child as directed by the doctor.Read all the information provided to you. Follow all instructions strictly.

    Sustained-release capsules:

    • Give this drug with or without food.
    • Have your child swallow whole. Tell your child not to chew, crush, or crush the tablet.
    • You can pour the contents of the capsule into applesauce or other soft foods. Have your child swallow right away without chewing and drink with water or juice.

    All other oral preparations:

    • Give this drug with food.

    Chewable Tablets:

    • Make sure your child chews the drug thoroughly before swallowing.

    Extended release tablets:

    • Have your child swallow whole. Tell your child not to chew, crush, or crush the tablet.
    • Do not give broken or chipped tablets to a child.
    • The tablet shell can sometimes be seen in the stool of a child. This is normal and not a cause for concern.
    • If your child has trouble swallowing this drug, talk to your doctor. There may be other ways of administering this drug.

    Liquid (suspension):

    • Shake well before use.
    • Care should be taken when measuring liquid doses. Use the dispenser that comes with the medicine.If a dispenser is not included in the package, ask your pharmacist for a dosing product for this drug.
    • Do not mix with other liquid medicines.
    • Do not give this drug to your child at the same time as any other liquid medicine.

    What if my child misses a dose of a drug?

    • Give the missed dose as soon as possible.
    • If it is time for your child to take the next dose, do not take the missed dose and then return to your child’s normal dosage schedule.
    • Do not give a double dose at the same time or additional doses.

    How do I store and / or discard this drug?

    • Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
    • Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
    • Dispose of unused or expired drugs.Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

    General information about medicines

    • If your child’s symptoms or health problems do not improve, or if they get worse, see your child’s doctor.
    • Do not share your child’s medicine with others or give anyone’s medicine to your child.
    • Some medicines may come with other patient information sheets. If you have questions about this drug, talk with your child’s doctor, nurse, pharmacist, or other healthcare professional.
    • If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

    Use of information by the consumer and limitation of liability

    This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are appropriate for a particular patient. This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient.Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional. Please consult your doctor for complete information on the possible risks and benefits of taking this drug.Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.


    © UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

    Tegretol – action, indications, side effects, drug interactions composition, instructions, reviews

    Home »Medicines» Tegretol – action, indications, side effects, drug interactions

    composition, instructions, reviews

    Tegretol CR is a drug with psychotropic, antiepileptic and neurotropic effects.It is widely used in neurology. It is especially recommended for the treatment of ailments such as bipolar disorder, trigeminal pain, epilepsy, manic syndromes, multiple sclerosis or alcohol abstraction in drug addicts. The medicine is only available with the present prescription. Depending on the means, dose and form, the price of tegretol ranges from 14 to 26 zlotys.

    tegretol CR it contains the active ingredient carbamazepine and is available in two different doses – 200 mg and 400 mg.Also comes in the form of a syrup. Carbamazepine has a membrane-stabilizing effect on nerve cells that are overstimulated. The product alleviates the effects of alcohol withdrawal in people who depend on it, reduces aggressiveness and irritability, and repels feelings of anxiety and depression. In addition, it prevents bouts of pain in the trigeminal nerve.

    Your doctor will determine your dose. In epilepsy, it usually starts with a dose of 100-200 twice a day and increases gradually.For the treatment of bipolar disorder and manic syndromes, the optimal dose is 400-1600 mg, for alcohol withdrawal syndrome 200 mg 3 times a day, and for trigeminal nerve pain 200-400 mg per day.

    Before using the drug tegretol CR , carefully read its instructions. Do not take this medication if you are allergic to any of its ingredients. Not indicated for people with hepatic porphyria, atrioventricular blocks, bone marrow disorders. In addition, MAO inhibitors should be discontinued two weeks before starting carbamazepine therapy.

    The drug, like any other drug, can cause side effects and more often include, among others, dizziness and headache, drowsiness, double vision, vomiting, nausea, fatigue, dermatitis, hives, weight gain, edema and fluid retention. In addition, dangerous side effects such as arrhythmias, liver failure, embolic blood clots, and more can rarely occur. In case of adverse reactions, consult a doctor immediately.

    Tegretol should not be taken, for example, MAO inhibitors, drugs that increase the amount of carbamazepine in the blood, incl.