What is mefenamic acid used for. How does mefenamic acid work. What are the potential side effects of mefenamic acid. How should mefenamic acid be taken. What precautions should be considered when using mefenamic acid.

Understanding Mefenamic Acid: An Overview

Mefenamic acid is a potent non-steroidal anti-inflammatory drug (NSAID) commonly prescribed for pain relief and inflammation reduction. Known by its brand name Ponstan, this medication has gained popularity for its effectiveness in managing various painful conditions. But what exactly is mefenamic acid, and how does it work?

Mefenamic acid belongs to a class of drugs called NSAIDs, which work by inhibiting the production of prostaglandins, chemicals in the body responsible for pain and inflammation. By blocking the enzymes called cyclo-oxygenase (COX), mefenamic acid effectively reduces the body’s inflammatory response, providing relief from pain and discomfort.

Key Features of Mefenamic Acid

• Available as capsules, tablets, and oral liquid medicine
• Suitable for adults and children over 12 years of age
• Typically prescribed for short-term use
• Requires a prescription in most countries

Medical Uses of Mefenamic Acid: When Is It Prescribed?

Mefenamic acid is a versatile medication with several applications in pain management. Healthcare providers often prescribe it for various conditions characterized by pain and inflammation. What are the primary medical uses of mefenamic acid?

1. Arthritis pain relief
2. Menstrual pain and heavy menstrual bleeding
3. Post-operative pain management
4. Toothache and dental pain
5. Headaches and migraines

Its effectiveness in managing menstrual pain has made mefenamic acid particularly popular among women. Many find relief from the debilitating cramps and discomfort associated with their menstrual cycles through the use of this medication.

The Mechanism of Action: How Mefenamic Acid Works

Understanding how mefenamic acid works in the body is crucial for appreciating its benefits and potential risks. How does this NSAID provide pain relief and reduce inflammation?

Mefenamic acid primarily works by inhibiting the production of prostaglandins. These are hormone-like substances that play a role in various bodily functions, including inflammation and pain sensation. By blocking the COX enzymes responsible for prostaglandin production, mefenamic acid effectively reduces pain and inflammation at the source.

The Prostaglandin Connection

Prostaglandins are produced at sites of injury or damage in the body. They contribute to:

• Pain sensation
• Inflammation
• Fever
• Blood clotting
• Protection of the stomach lining

By reducing prostaglandin production, mefenamic acid not only alleviates pain and inflammation but also affects these other bodily processes. This broad impact explains both its therapeutic effects and potential side effects.

Dosage and Administration: How to Take Mefenamic Acid Safely

Proper dosage and administration of mefenamic acid are crucial for maximizing its benefits while minimizing potential risks. How should one take mefenamic acid, and what dosages are typically prescribed?

The standard dosage for adults is 500 mg, usually taken three times a day. This can be administered as two 250 mg capsules or one 500 mg tablet. For menstrual pain, doctors often recommend starting the medication on the first day of bleeding and continuing for a few days each month.

Important Administration Guidelines

• Always take mefenamic acid with food to protect your stomach
• Follow your doctor’s instructions precisely
• Do not exceed the prescribed dose
• If you miss a dose, take it as soon as you remember, unless it’s nearly time for your next dose
• Never double up on doses to make up for a missed one

It’s essential to note that mefenamic acid is typically prescribed for short-term use. Long-term use should only occur under close medical supervision due to the potential for side effects.

Precautions and Contraindications: Who Should Avoid Mefenamic Acid?

While mefenamic acid is generally safe and effective, it’s not suitable for everyone. Certain medical conditions and factors may increase the risk of adverse effects. Who should exercise caution or avoid using mefenamic acid altogether?

Individuals with the following conditions should consult their healthcare provider before taking mefenamic acid:

• History of stomach or duodenal ulcers
• Inflammatory bowel disorders (e.g., Crohn’s disease, ulcerative colitis)
• Asthma or allergic disorders
• Liver or kidney problems
• Heart conditions or circulatory issues
• High blood pressure
• Blood clotting disorders
• Epilepsy
• High blood sugar or cholesterol levels
• Connective tissue disorders like systemic lupus erythematosus (SLE)
• Porphyria (a rare inherited blood disorder)

Pregnant women, those trying to conceive, and breastfeeding mothers should also consult their healthcare provider before using mefenamic acid. The medication may pose risks to the developing fetus or nursing infant.

Drug Interactions

Mefenamic acid can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications you’re taking, including over-the-counter drugs, herbal supplements, and other NSAIDs.

Potential Side Effects: Understanding the Risks of Mefenamic Acid

Like all medications, mefenamic acid can cause side effects. While not everyone experiences these, it’s important to be aware of potential adverse reactions. What are the most common side effects of mefenamic acid?

• Stomach upset, nausea, and indigestion
• Diarrhea or constipation
• Headache
• Dizziness
• Drowsiness
• Skin rashes

More serious side effects, although rare, can include:

• Stomach ulcers or bleeding
• Allergic reactions (including difficulty breathing, swelling of the face or throat)
• Liver or kidney problems
• Increased risk of heart attack or stroke (with long-term use)

If you experience any severe or persistent side effects, it’s crucial to seek medical attention promptly. Your healthcare provider can assess the situation and determine whether to adjust your treatment plan.

Long-Term Use Considerations: Balancing Benefits and Risks

While mefenamic acid can be highly effective for short-term pain relief, long-term use requires careful consideration. What are the potential risks associated with prolonged use of mefenamic acid?

Long-term use of NSAIDs like mefenamic acid has been associated with an increased risk of cardiovascular events, such as heart attacks and strokes. Additionally, prolonged use can lead to gastrointestinal complications, including ulcers and bleeding.

Strategies for Safe Long-Term Use

If long-term use of mefenamic acid is necessary, healthcare providers may implement strategies to minimize risks:

• Prescribing the lowest effective dose
• Regular monitoring of liver and kidney function
• Combining with stomach-protecting medications
• Periodic reassessment of the need for continued treatment

It’s crucial for patients on long-term mefenamic acid therapy to maintain open communication with their healthcare providers and report any unusual symptoms promptly.

Alternatives to Mefenamic Acid: Exploring Other Pain Management Options

While mefenamic acid is effective for many individuals, it’s not the only option for pain management. What alternatives are available for those who cannot take mefenamic acid or prefer different treatments?

Several alternatives to mefenamic acid exist, each with its own benefits and considerations:

1. Other NSAIDs (e.g., ibuprofen, naproxen)
2. Acetaminophen (paracetamol)
3. Topical pain relievers
4. Physical therapy and exercise
5. Complementary therapies (e.g., acupuncture, massage)
6. Prescription pain medications (for severe cases)

The choice of alternative depends on the specific condition, individual health factors, and personal preferences. It’s essential to consult with a healthcare provider to determine the most appropriate pain management strategy.

Natural Alternatives

Some individuals prefer natural alternatives for pain relief. While these should not replace prescribed medications without medical advice, they may offer complementary benefits:

• Omega-3 fatty acids (found in fish oil)
• Turmeric (contains curcumin, a natural anti-inflammatory)
• Ginger
• White willow bark (contains salicin, a compound similar to aspirin)
• Boswellia (Indian frankincense)

Always consult with a healthcare provider before incorporating natural remedies into your pain management regimen, as they can interact with medications and may not be suitable for everyone.

Mefenamic Acid in Special Populations: Considerations for Specific Groups

The use of mefenamic acid requires special consideration in certain populations due to potential risks or altered effectiveness. How does mefenamic acid use differ among various groups?

Elderly Patients

Older adults may be more susceptible to side effects from NSAIDs, including mefenamic acid. Healthcare providers often prescribe lower doses and monitor these patients more closely. The risk of gastrointestinal bleeding and cardiovascular events may be higher in this population.

Children and Adolescents

Mefenamic acid is generally not recommended for children under 12 years of age. For adolescents, the dosage may be adjusted based on body weight. Parents and caregivers should closely follow the prescribing physician’s instructions.

Pregnant and Breastfeeding Women

The use of mefenamic acid during pregnancy, especially in the third trimester, is generally avoided due to potential risks to the fetus. It may also pass into breast milk, so breastfeeding mothers should consult their healthcare provider before use.

Patients with Chronic Conditions

Individuals with chronic conditions such as asthma, hypertension, or kidney disease require careful monitoring when using mefenamic acid. In some cases, alternative pain management strategies may be preferable.

Mefenamic Acid and Lifestyle: Maximizing Benefits and Minimizing Risks

While mefenamic acid can be an effective tool for pain management, combining it with healthy lifestyle choices can enhance its benefits and reduce potential risks. How can lifestyle factors complement mefenamic acid therapy?

Diet and Nutrition

A balanced diet rich in anti-inflammatory foods can support pain management efforts. Consider incorporating:

• Omega-3 fatty acids (found in fatty fish, flaxseeds, and walnuts)
• Antioxidant-rich fruits and vegetables
• Whole grains
• Lean proteins

Avoiding processed foods, excessive sugar, and alcohol can also help reduce inflammation in the body.

Exercise and Physical Activity

Regular exercise can complement the pain-relieving effects of mefenamic acid by:

• Improving joint flexibility and range of motion
• Strengthening muscles to support joints
• Releasing endorphins, natural pain-relieving chemicals
• Promoting better sleep, which can help manage pain

Always consult with your healthcare provider before starting a new exercise regimen, especially if you have chronic pain or other health conditions.

Stress Management

Chronic stress can exacerbate pain and inflammation. Incorporating stress-reduction techniques can enhance the effectiveness of mefenamic acid:

• Meditation and mindfulness practices
• Deep breathing exercises
• Yoga or tai chi
• Regular relaxation time
• Adequate sleep

These practices can help manage pain perception and improve overall well-being.

Future Developments: Research and Innovations in Pain Management

As medical science advances, new approaches to pain management continue to emerge. What future developments might impact the use of mefenamic acid and other pain medications?

Targeted NSAIDs

Researchers are working on developing NSAIDs that target specific pain pathways more precisely, potentially reducing side effects while maintaining efficacy. These next-generation drugs could offer improved safety profiles compared to current NSAIDs like mefenamic acid.

Personalized Medicine

Advancements in genetic testing and biomarker identification may lead to more personalized pain management strategies. This could help healthcare providers predict which patients are most likely to benefit from mefenamic acid or other treatments, and who might be at higher risk for side effects.

Alternative Delivery Methods

New delivery methods for pain medications are being explored, including:

• Transdermal patches
• Nasal sprays
• Long-acting formulations

These innovations could potentially improve the efficacy and safety of pain medications like mefenamic acid.

Combination Therapies

Research is ongoing into combination therapies that pair NSAIDs with other pain-relieving or protective agents. These combinations could potentially enhance pain relief while mitigating side effects.

As research progresses, it’s crucial for patients and healthcare providers to stay informed about new developments in pain management. While mefenamic acid remains an effective option for many, future innovations may offer even better solutions for pain relief and inflammation control.

Mefenamic acid for pain and inflammation (Ponstan)

Mefenamic acid for pain and inflammation

Ponstan

In this article

• About mefenamic acid
• Before taking mefenamic acid
• How to take mefenamic acid
• Getting the most from your treatment
• Can mefenamic acid cause problems?
• How to store mefenamic acid
• Important information about all medicines

About mefenamic acid

Anti-inflammatory painkillers like mefenamic acid are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just ‘anti-inflammatories’. Mefenamic acid is used to treat painful conditions such as arthritis, pain associated with heavy menstrual bleeding, and pain after surgical operations.

Mefenamic acid works by blocking the effect of natural chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Before taking mefenamic acid

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking mefenamic acid, it is important that your doctor knows:

• If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.
• If you have asthma or any other allergic disorder.
• If you are pregnant, trying for a baby, or breastfeeding.
• If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.
• If you have a heart condition or a problem with your blood vessels or circulation.
• If you have high blood pressure.
• If you have any blood clotting problems.
• If you have epilepsy.
• If you have high blood sugar or cholesterol levels.
• If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.
• If you have a rare inherited blood disorder called porphyria.
• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as as herbal and complementary medicines.
• If you have ever had an allergic reaction to any other NSAID (such as aspirin, ibuprofen, diclofenac, and indometacin), or to any other medicine.

How to take mefenamic acid

• Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about mefenamic acid, and it will also provide you with a full list of the side-effects which you could experience from taking it.
• Take mefenamic acid exactly as your doctor tells you to. The usual dose is 500 mg, which is taken as two 250 mg capsules, or one 500 mg tablet. You will be asked to take this dose three times a day. If you are taking it for period pain, your doctor will likely suggest that you take it for a few days each month, starting on your first day of bleeding.
• Take mefenamic acid with food. This will help to protect your stomach from side-effects such as indigestion.
• If you forget to take a dose, take it as soon as you remember unless your next dose is due. If your next dose is due, then take the dose which is due but leave out the forgotten one. Do not take two doses together to make up for a missed dose.

Getting the most from your treatment

• Your doctor will try to prescribe you mefenamic acid for the shortest time possible to reduce the risk of side-effects. If you need to take it over a long period of time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.
• Try to keep any regular appointments with your doctor. This is so your doctor can check on your progress. It is especially important if you are taking mefenamic acid for a long-term condition.
• If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories. If this happens to you, you should stop taking mefenamic acid and see your doctor as soon as possible.
• There is known to be a small increased risk of heart and blood vessel problems in people taking some anti-inflammatory painkillers long-term. Your doctor will explain this to you and will prescribe the lowest suitable dose for the shortest time in order to reduce the risk. Do not take more than the recommended dose.
• If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because you should not take mefenamic acid with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought ‘over the counter’.
• If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Can mefenamic acid cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with mefenamic acid. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer’s printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer’s information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: if you experience any of the following less common but possibly serious symptoms, stop taking mefenamic acid and contact your doctor for advice straightaway:

• If you have any breathing difficulties such as wheeze or breathlessness.
• If you have any signs of an allergic reaction such as swelling around your mouth or face, or an itchy skin rash.
• If you pass blood or black stools, bring up (vomit) blood, or have severe stomach pains.

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

How to store mefenamic acid

• Keep all medicines out of the reach and sight of children.
• Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

• Manufacturer’s PIL, Ponstan® 250 mg Capsules; Chemidex Pharma Ltd, The electronic Medicines Compendium. Dated March 2020.

• Medicines Complete BNF 85th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.

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Mefenamic Acid – Overview

Mefenamic acid is a medication sometimes prescribed to people who need relief from mild pain, including menstrual pain. People who might need a mefenamic acid prescription can use Push Health to connect with a local medical provider who can prescribe mefenamic acid medication, including mefenamic acid 500 mg and mefenamic acid 250 mg tablets, when appropriate to do so.

Mefenamic Acid – Dosage and Cost

Mefenamic acid is sometimes marketed under the brand Ponstel and, like celecoxib (Celebrex), ibuprofen (Motrin), meloxicam (Mobic) and naproxen (Naprosyn), belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). Mefenamic acid can help bring relief from mild to moderate pain, including menstrual pain, and potentially other pain syndromes. It is not entirely clear how mefenamic acid exerts its actions but it may involve modulation of prostaglandins in the body. Mefenamic acid is sometimes prescribed with a loading dose of mefenamic acid 500 mg followed by mefenamic acid 250 mg at various times during the day, depending on the health needs of the patient. Mefenamic acid tablets are moderately affordable, costing approximately $4 per mefenamic acid tablet at many pharmacies in the United States. Mefenamic acid coupons may help reduce the cost of a mefenamic acid prescription and some insurance plans may help with costs associated with a mefenamic acid prescription.

Request Mefenamic Acid 500 mg »

Can I Buy Mefenamic Acid Online?

Mefenamic acid requires a prescription to be obtained at a pharmacy in the United States. Due to this restriction, mefenamic acid OTC is not available and it is not possible to just buy mefenamic acid online as the initial step is getting a mefenamic acid prescription from a licensed medical provider. People who might need a mefenamic acid prescription, however, can connect with a licensed provider through Push Health who can prescribe mefenamic acid medication, including mefenamic acid 500 mg and mefenamic acid 250 mg tablets, when appropriate to do so.

Mefenamic Acid – Side Effects

Mefenamic acid prescription medication can cause side effects such as nausea, abdominal discomfort, vomiting and fatigue. People with a history of liver problems should generally avoid using mefenamic acid medication. Mefenamic acid can cause kidney dysfunction, particularly when used excessively. Prior to using mefenamic acid tablets, questions and concerns should be discussed with a pharmacist and qualified medical provider. Mefenamic acid and alcohol should generally not be used together. People with an allergy to mefenamic acid or similar medications should avoid using mefenamic acid prescription medication.

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More Mefenamic Acid Information

• Mefenamic Acid – Medline

Last updated March 21, 2022. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.

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Mefenamic acid: susceptibility features

Mefenamic acid (active intoxicant) – non-steroidal anti-inflammatory and anti-rheumatic faces behind the chemical structure lie down to the group of fenamates. The drug blocks the vibration of speech, which is considered to be the development of inflammation, and blocks the absorption of the enzyme cyclooxygenase (COX 1 and COX 2). Tse give їyy ability to manifest:

• anti-flash;
• antipyretic;
• Insignificant analgesic effect.

Ale, krіm tsikh efektіv, lіki zdatnі:

• activate the synthesis of interferon in the body;
• change the penetration of the wall of blood vessels;
• near the burning fire, the clitin changed;
• disruption in clitins by the reaction of oxide phosphorylation;
• significantly change the activity of enzymes in lysosomes;
• heal wounds;
• increase the resistance of clitin to ovnіshnіh i vnutrіshnіh ushkodzhen;
• normalize the protein structure of cellular membranes.

Release form

Taken orally, so you can buy mefenamic acid in pharmacies in a number of forms:

• capsules of 250 and 500 mg 10 and 20 pieces;
• tablets for internal administration 0.25 and 0.5 g No. 10 and 20.

In the pharmacy it is also possible to use її analogues under other names: Mefenaminka, Amifena ІС. The stench of the virobnik factory is blown away.

Buy chi to know the price of mefenamic acid or other medical products and hygiene items at the additional site MIS Pharmacy 9-1-1.

Pharmacological power

Pharmacodynamics The mechanism of protizapalnye dії razumovaniya zdatnіst prinіchuvat synthesis of mediators of inflammation (prostaglandins, serotonin, kinіnіv etc.), reduce the activity of lysosomal enzymes, yak take part in the inflammatory reaction. Mefenamic acid stabilizes protein ultrastructural membranes of cells, changes the penetration of vessels, disrupts the processes of oxide phosphorylation, inhibits the synthesis of mucopolysaccharides, galmuic proliferation of cells in the inflammation cavity, promotes cell resistance stimulates healing of wounds. Fever-reducing power leads to the development of galvanic synthesis of prostaglandin and influx on the thermoregulation center.

Mefenamic acid stimulates the release of interferon.

In the mechanism of pain relief, the order of the infusion on the central mechanism of pain sensitivity, the original role of playing the muscles in the infusion on the inflamed cavity and the building of the galmuvati of the application of algogenics (kini, histamine, serotonin).

Pharmacokinetics

After ingestion of internal mefenamic acid, it may be wetted in the herbal tract. The maximum concentration in the blood is observed in 2-4 years after taking. Riven in the blood is a proportional dose. Equally important concentration (20 mcg / ml) is assigned for 2 doses of ingestion (1 g 4 times per dose). Calling on 90% with blood albumin. In the liver, it metabolizes by way of oxidation, hydrolysis, glucuronidation. The period of drinking (T1 / 2) becomes 2-4 years. It is important to excrete in the body in the unchangeable form in the presence of metabolites in the form of drugs (67% of the dose), with faeces (20-25%).

Prescribed as an antispasmodic and immunomodulatory remedy for:

• influenza;
• acute infections of the dyhal ways in viral etiology;
• pain syndrome in m’yazakh, loam, teeth, head of low and medium strength;
• bol with hormonal dysfunction and primary dysmenorrhea;
• Illusion of the musculoskeletal apparatus: ankylosing spondylitis, arthrosis, rheumatoid arthritis.

The variability of the drug Mefenamic acid according to the temperature is listed in the catalog of the MIS Pharmacy website 9-1-1.

At what doses and how do you take drugs?

Mefenamic acid tablets are prescribed for adults and children from 12 years of age, drunk after a day, drinking milk. Drink 250 mg / 500 mg 3 or 4 r / day. At the beginning of therapy, the dosage for doba can be reduced to 3.0, and at times of the present, the effect can be reduced to 1.0 per day. Mefenamic acid capsules are prescribed at the same doses.

Mefenamic acid for influenza and GRVI is taken for 5-7 days.

Mefenamic acid in the case of headaches is prescribed according to the instructions.

The course of healing in case of ill-healthy swamps can take 20 days to 2 months and more. With the treatment of pain syndrome, the course of treatment is three to 7 days.

For children aged 5 to 12 years old, sometimes take 0.25 g tablets 3-4 times a day.

You can buy the drug Mefenamic acid for GRVI in a number of pharmacies-partners of MIS Pharmacy 9-1-1.

Contraindications and maladaptive manifestations

It is not recommended to vicorate with such mills:

When mefenamic acid is ingested, the most common side reactions are damage to the side of the intestinal tract.

Intermittent reactions rarely, but can be so:

1. Herbal system: nausea, increased acidity of the tube (oven), constipation, gastritis, dyspepsia, flatulence, vomit, increased hepatic rheum transaminase in the blood.
2. Heart judge: increased pressure, disruption of the rhythm of the heart (arrhythmias).
3. Dychal system: spasm of the bronchus, impaired frequency and rhythm of breathing.
4. Sichoid system: cystitis, nirk deficiency, allergic glomerulonephritis, hematuria, protein in the sciatica, change or increase in the number of sciatica seen.
5. Blood: leukopenia, anemia, decreased levels of eosinophils and platelets.
6. Nervous system: difficult to get drunk, drativity, impaired concentration of respect, drowsiness.
7. Sensor system: lowering the light, ringing and noise at the ears.
8. Shkira: kropyvyanka, nabryak, sverbіzh.

Specifics of congestion abo kropivyanka).

NPZZ should take care of patients who have a history of ailment of the intestinal tract (virazkovy colitis, Crohn’s ailment), stools may aggravate ailment. As a result of congestion of mefenamic acid, it has led to mucosal-intestinal bleeding or perforation, it is necessary to administer the drug.

Patients of a frail age may develop a risk of development of side effects from the side of the intestinal tract, especially intestinal bleeding and perforation, which can lead to death, this can be done id from the smallest dosage. Chicken and alcohol intake and risk factors.

The use of mefenamic acid may lead to disruption of the intestinal tract (eg, diarrhea). The stench can be blamed as if after the stagnation of the medical care, so after the tribal reception. Even if these symptoms are winickly, the next thing to do is to stop the medical treatment.

Patients with risk factors for cardiovascular and cerebrovascular complications (such as arterial hypertension, ischemic heart disease, diabetes mellitus) may be treated with mefenamic acid For retelnoy analysis spіvvіdnoshnja korist/risik.

The use of mefenamic acid is necessary in case of the first appearance of a visip on the skin, subcutaneous mucosa, or in case of any other manifestation of hypersensitivity.

It is necessary to be careful in case of mefenamic acid stasis in patients, so that concomitant therapy with drugs that reduce the risk of bleeding: corticosteroids, anticoagulants (warfarin) and aspirin.

Mefenamic acid does not stagnate in the mouth.

Interactions with other medical conditions and other types of interactions tsії and increase the rіven of cardiac glycosides in blood plasma.

Zidovudine: NSAIDs increase the risk of hematological toxicity. There is a risk of hemorrhage in suglob and hematomas in VIL-positive ailments for hemophilia, which should be immediately treated with zidovudine.

With a total accumulation of mefenamic acid and methotrexate, the toxic effects of methotrexate are increased, possibly increasing the potential of methotrexate in blood plasma.

Overdose

Symptoms: epigastric discharge, nausea, vomiting, drowsiness, headache, rarely diarrhea, disorien- tation, confusion wife, noise in the ears, loss of sound, sometimes judgement (mefenamic acid may tend to induce tonic – clonic court in case of overdose. In severe depressions – slunic-intestinal bleeding, dyspnoea, arterial hypertension, micturition of four groups of m’ulcers, coma.0004

There is no specific antidote. Washing the sluice with a suspension of activated water. Service of cutting, forcing diuresis. Symptomatic therapy. Hemosorption and hemodialysis are of little effect due to the microbinding of mefenamic acid with blood proteins.

Parts or trials were judged and followed up for the help of intravenous administration of diazepam.

Do you drink watery and lactating?

Insufficiency of the drug during pregnancy and breastfeeding is contraindicated.

What is the next time to stop the drug during the hour of the car and the work that will help the concentration of the drug?

Faces can provoke drowsiness, fuzzy fatness, judge, if the time of stagnation of mefenamic acid is necessary, it will work, yak increase the concentration of blood.

What are the analogues? What is the shortest version of analogues?

There are no analogues on the market, which would most likely have a pharmacological effect.

The current price of the drug Mefenamic acid for colds is indicated in the catalog of the MIS Pharmacy website 9-1-1.

List of vicarious literature

1. Compendium – medicinal preparations;
2. Sovereign register of medical supplies;
3. JAMA.

The largest part of the supply of pharmacies

What is it prescribed for?

Zasіb vykoristovuyut in GRVI as anti-Russian, immunomodulatory, antipyretic and protizapalny zasib. It can also be used for pain of medium and low intensity, as well as antispasmodic faces in pathologies in the musculoskeletal system.

What is the right way to drink?

As indicated, take 1–2 tablets/capsules 3–4 r/day.

When are you starting to die?

The maximum concentration of the drug is observed in the blood after 2-4 years – a therapeutic effect occurs.

How many pills Mefenaminc?

Current varity is listed on the MIS Pharmacy website 9-1-1.

Mefenamic acid instructions

MEPHENAMIC ACID
(UA/17139/01/01)

Release form:

tablets of 500 mg; 10 tablets in a blister; 2 blisters in a pack of cardboard

Stock:

1 tablet mefenamic acid 500 mg

Manufacturer:

Ukraine

MEPHENAMIC ACID
(UA/18370/01/01)

Release form:

tablets of 500 mg, 10 tablets per blister; 10 tablets in a blister, 2 blisters in a pack

Stock:

1 tablet mefenamic acid 500 mg

Manufacturer:

Ukraine

MEPHENAMIC ACID
(UA/4974/01/01)

Release form:

capsules of 250 mg, 10 capsules in a blister, 2 blisters in a box

Stock:

1 capsule of revenge mefenamic acid 250 mg

Manufacturer:

India

MEPHENAMIC ACID
(UA/4974/01/02)

Release form:

capsules 500 mg, 10 capsules in a blister, 2 blisters in a box

Stock:

1 capsule of revenge mefenamic acid 500 mg

Manufacturer:

India

MEFENAMIC ACID-DARNITSIA
(UA/7015/01/01)

Release form:

tablets of 500 mg, 10 tablets per contour pack; 2 contour packs in packs

Stock:

1 tablet mefenamic acid 500 mg

Manufacturer:

Ukraine

Mefenamic acid price in Pharmacy 911

Name	Price
Mefenamic acid-Darnitsa tab. 500mg №20	110.40 UAH
Mefenamic acid caps. 250mg №20	UAH 59.20
Mefenamic acid caps. 500mg №20	UAH 82.80
Mefenamic acid tab. 500mg №20	UAH 56.10
Mefenamic acid tab. 500mg №20	UAH 44.80

Mefenamic acid capsules 500 mg №20

Application features

Brand name

Mefenamic acid

Active ingredient

Mefenamic acid

Dispensing conditions

Without prescription

Form

Capsules

Adults

Can

Allergics

905 94 Caution

Diabetics

Caution

Drivers

Caution

Children

C 5 years old

Pregnant

Not allowed

Lactating

Not allowed

Primary packaging

blister

Country of origin

India

Manufacturer

Flamingo

Route of administration

905 94 By mouth, solid

Description

Mefenamic acid capsules are used for the following indications:

• Acute respiratory viral infections and influenza.
• Pain of low and moderate intensity: muscle, joint, traumatic, dental, headache of various etiologies, postoperative and postpartum pain.
• Primary dysmenorrhea. Dysfunctional menorrhagia, including those caused by the presence of intrauterine contraceptives, in the absence of pathology of the pelvic organs.
• Inflammatory diseases of the musculoskeletal system: rheumatoid arthritis, rheumatism, ankylosing spondylitis.

Composition

Active ingredient: mefenamic acid;

1 capsule contains mefenamic acid 250 mg or 500 mg;

Excipients:

• capsules 250 mg talc lactose monohydrate, corn starch sodium lauryl sulfate; silicon dioxide; magnesium stearate
• capsules 500 mg talc, stearic acid, corn starch, sodium lauryl sulfate, crospovidone.

Contraindications

Hypersensitivity to the components of the drug. Bronchospasm, Quincke’s edema, rhinitis, bronchial asthma or a history of urticaria that occurred after the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs). Simultaneous administration of specific COX-2 inhibitors. Peptic ulcer of the stomach and duodenum, including a history, inflammatory bowel disease, diseases of the hematopoietic organs, severe heart failure, severe liver or kidney dysfunction, gastrointestinal bleeding or perforation caused by non-steroidal anti-inflammatory drugs.

How to use

Take orally the drug should be taken after meals.

Adults and children over 12 years old, 250-500 mg 3-4 times a day. If necessary, the dose can be increased to 3 g per day. After achieving a therapeutic effect, the daily dose should be reduced to 1 g.

The course of treatment for diseases of the joints can last from 20 days to 2 months or more. In the treatment of pain syndrome, the course of treatment lasts up to 7 days.

Application features

Pregnant women

The drug is not used by women during pregnancy or lactation.

Children

Recommended for children over 12 years of age.

Drivers

Caution should be exercised when driving vehicles or working with mechanisms that require increased attention, as sometimes the use of the drug can cause drowsiness, blurred vision, convulsions.

Overdose

Symptoms: epigastric pain, nausea, vomiting, drowsiness. In severe cases – gastrointestinal bleeding, respiratory depression, arterial hypertension, twitching of certain muscle groups, coma.

Treatment. There is no specific antidote. Gastric lavage with activated charcoal suspension. Alkalinization of urine, forced diuresis. Symptomatic therapy. Hemosorption and hemodialysis are ineffective due to the strong binding of mefenamic acid to blood proteins.

Side effects

• On the part of the organs of vision: blurred vision, reversible loss of the ability to distinguish colors, eye irritation.
• From the side of the hearing and vestibular apparatus: ringing in the ears, otalgia.
• From the respiratory system, chest organs and mediastinum: dyspnea, bronchospasm.
• From the gastrointestinal tract: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, enterocolitis, colitis, exacerbation of colitis and Crohn’s disease, gastritis, hepatotoxicity, steatorrhea, cholestatic jaundice, hepatitis, pancreatitis, hepatorenal syndrome, hemorrhagic gastritis, peptic ulcer with or without bleeding. Gastrointestinal bleeding, perforation or gastrointestinal bleeding, sometimes fatal, especially in elderly patients, dyspepsia, constipation, diarrhea.
• From the side of the kidneys and urinary system: dysuria, cystitis. Renal dysfunction, albuminuria, hematuria, oliguria or polyuria, renal failure, including papillary necrosis, acute interstitial nephritis, nephrotic syndrome, allergic glomerulonephritis, hyponatremia, hyperkalemia.
• From the nervous system: drowsiness or insomnia, weakness, irritability, agitation, headache, blurred vision, convulsions, optic neuritis, paresthesia, dizziness, stiff neck, fever, disorientation. On the part of the psyche: confusion, depression, hallucinations.
• From the side of the cardiovascular system: arterial hypertension, arrhythmia, rarely – congestive heart failure, peripheral edema, syncope, arterial hypotension, palpitations, shortness of breath, thrombotic complications (eg myocardial infarction or stroke).
• On the part of the blood and lymphatic system: aplastic anemia, autoimmune hemolytic anemia, prolongation of bleeding time, eosinophilia, leukopenia, thrombocytopenia, decreased hematocrit, thrombocytopenic purpura, agranulocytosis, neutropenia, pancytopenia, bone marrow hypoplasia.
• From the immune system: hypersensitivity reactions, including skin rashes, pruritus, facial edema, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, urticaria, bullous pemphigus, photosensitivity, asthma, anaphylaxis .
• From the side of the skin and subcutaneous tissue: purpura, skin rashes, pruritus, erythema multiforme, urticaria, bullous pemphigus.
• Laboratory indicators: impaired glucose tolerance in patients with diabetes mellitus, a positive reaction in some tests for the presence of mefenamic acid and its metabolites in bile and urine. Increased levels of liver enzymes in blood plasma.

Interaction

Thiamine, pyridoxine hydrochloride, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, diphenhydramine increase the analgesic effect of the drug.

Tacrolimus: possible increased risk of nephrotoxicity.

Storage conditions

Store in the original container at a temperature not exceeding 30°C.

Keep out of reach of children.

Shelf life – 3 years.

Editorial group

Shcherbakova Alexandra Olegovna

Author

Gritsyuk Liana Georgievna

Reviewer

Creation date: 03/31/2023

Update date: 04/05/2023

Pay attention

Description of the drug Mefenamic acid capsules 500 mg №20 on this page is a simplified version from anc.