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Menthol in biofreeze: Biofreeze (Menthol) Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


Biofreeze (Menthol) Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


Different brands of this product have different uses. Some brands are used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). Some brands are used to help relieve itching and skin irritation (such as due to sunburn, insect bites, or minor scrapes). Menthol is known as a counterirritant. It works by causing the skin to feel cool and then warm.

How to use Biofreeze (Menthol) 4 % Topical Gel Dermatological Irritants-Counter-Irritant Formulations

If you are using the over-the-counter product to self-treat, read and follow all directions on the product package before using this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, use it as directed.

This medication is for use on the skin only. Apply to the affected area no more than 3 to 4 times a day. If you are using the cream, gel, or liquid, rub in gently and thoroughly. Some liquid forms of this medication should be shaken before use. Check the manufacturer’s information for specific directions. Let the medicine dry completely before letting anyone else touch the area.

Wash your hands well after applying unless you are using this medication to treat the hands. Avoid getting this medication in your eyes, nose, or mouth. If you do get the medication in those areas, flush with plenty of water.

Do not apply to serious burns or deep wounds. Do not bandage or tightly wrap the affected area. Doing so may increase the risk of side effects. You may cover the area loosely to protect clothing.

Heat can increase the risk of side effects. Do not apply this medication right before, during, or after activities that increase skin temperature (such as bathing, swimming, heavy exercise). Wait until your skin has cooled before applying the medication. Do not use a sunlamp/tanning bed, hot water bottle, or heating pad/device on the treated area.

Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Read the label carefully to make sure you have the right product for you. Ask your pharmacist if you have any questions.

Tell your doctor if your condition lasts for more than 7 days, or if it gets worse, or if it keeps returning. If you think you may have a serious medical problem, get medical help right away.

Side Effects

Redness, warmth, or irritation at the application site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop using this medication and tell your doctor right away if you have any serious side effects, including: blistering/swelling at the application site, increased/unusual pain at the application site.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using this product, tell your doctor or pharmacist if you are allergic to menthol; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Biofreeze (Menthol) 4 % Topical Gel Dermatological Irritants-Counter-Irritant Formulations interact with other drugs you are taking?

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This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Keep all regular medical and lab appointments.

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.


Biofreeze (menthol) 4 % topical gel

Color: Shape: Imprint:

This medicine is a gel


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Drug Survey

Have you ever purchased Biofreeze (Menthol) 4 % Topical Gel Dermatological Irritants-Counter-Irritant Formulations?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven’t purchased but considering

Don’t plan to purchase

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Menthol Topical (Biofreeze) – Side Effects, Interactions, Uses, Dosage, Warnings

Brand Names:ActivICE, ActivOn Arthritis, ActivOn Joint and Muscle, Arctic Relief Pain Relieving, Aspercreme Heat Pain Relieving, Asperflex Maximum Strength


Menthol is either manmade or made from the extracts of mint oil. Menthol provides a cooling sensation when applied to the skin, which helps relieve pain in the tissues underneath the skin.

Menthol topical (for use on the skin) is used to provide temporary relief of minor arthritis pain, backache, muscles or joint pain, or painful bruises.

There are many brands and forms of menthol available. Not all brands are listed on this leaflet.

Menthol topical may also be used for purposes not listed in this medication guide.


What is Menthol Topical (Biofreeze) used for?

  • Cough
  • Pain
  • Pruritus


What is the most important information I should know about Menthol Topical (Biofreeze)?

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had an allergy to aspirin or salicylate medicine.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

If you apply menthol to your chest, avoid areas that may come into contact with a nursing baby’s mouth.

Ask a doctor before using this medicine on child 12 years old or younger.

Side Effects

What are the side effects of Menthol Topical (Biofreeze)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe burning, stinging, redness, or irritation after using this medicine; or
  • pain, swelling, or blistering where the medicine was applied.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Menthol Topical (Biofreeze) if I’m pregnant or breastfeeding?

Ask a doctor before using this medicine if you are pregnant or breastfeeding.


What drugs and food should I avoid while taking Menthol Topical (Biofreeze)?

If this medication gets in your eyes, nose, or mouth, rinse with water.

Avoid using other topical pain medications on the areas you treat with menthol.

Dosage Guidelines & Tips

How to take Menthol Topical (Biofreeze)?

Use Menthol Topical (Biofreeze) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Menthol Topical (Biofreeze)?

Since this medicine is when needed, you are not likely to miss a dose.

Overdose Signs

What happens if I overdose on Menthol Topical (Biofreeze)?

If you think you or someone else may have overdosed on: Menthol Topical (Biofreeze),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Menthol Topical (Biofreeze), call 911




Color: maroon

Shape: oval

Flavor: cherry

Imprint: B

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Color: yellow

Shape: capsule

Flavor: honey lemon

Imprint: LUDENS

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Color: blue

Shape: oval

Flavor: menthol

Imprint: B

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Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health. 

BIOFRIZ – instructions for use, doses, side effects, reviews of the drug: gel for external use

BIOFRIZ (gel for external use), instructions for medical use RU No. LP-000959

Date of last change: 900 03 02/09/2017


  • Active substance
  • ATX
  • Pharmacological group
  • Composition and form of release
  • Compound
  • Description of the dosage form
  • Pharmacological properties
  • Pharmaco-therapeutic group
  • Indications
  • Contraindications
  • Dosage and administration
  • Side effects
  • Interaction
  • Overdose
  • special instructions
  • Release form
  • Terms of dispensing from pharmacies
  • Storage conditions
  • Best before date
  • Reviews

Active ingredient

Camphor + Levomenthol (Camphor + Levomenol)


M02AX10 Other preparations

Pharmacological group

Other non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs, in combinations

Local irritants in combinations

Composition and formulation

Gel for external use


Composition per 100 g:

Active ingredients:

Levomenthol 3. 5 g (3.5%)

Camphor (natural) 0.2 g (0.2%)

Auxiliary components: Paraguayan holly extract, isopropanol, carbomer, trolamine (triethanolamine), silicon dioxide, methyl parahydroxybenzoate (methyl paraben), propylene glycol, glycerol (glycerin), riboflavin, brilliant blue dye, deionized water .

Description of dosage form

Clear blue-green or green gel with a menthol odor.

Pharmacological properties

Combination agent of natural origin; It has a locally irritating (“distracting”), mild local anesthetic effect.

Pharmaco-therapeutic group

Local irritant of natural origin.


As a “distraction” remedy for arthralgia (joint pain), myalgia, sciatica, sciatica, myositis.


Hypersensitivity to the components of the drug, dermatological diseases, violations of the integrity of the skin in the places of the intended application of the drug, pregnancy, breastfeeding, age up to 18 years.

Dosage and Administration

Information for healthcare professionals only.
Are you a healthcare professional?

External. Adults should apply 2-3 g of gel to the painful area and rub into the skin with light massage movements. The procedure is carried out depending on the intensity of pain 3-4 times a day. The duration of therapy depends on the nature and severity of the disease. The average course of treatment is 10 days.

Side effects

Possible skin itching, skin irritation at the site of application of the drug, allergic reactions.


Information for healthcare professionals only.
Are you a healthcare professional?

Not described.


So far, no cases of overdose have been reported with the use of the drug.

Special instructions

Gel must be used for external use only!

Avoid contact of the gel with eyes, mucous membranes, wounds, and affected areas of the skin.

Do not use the gel simultaneously with other topical medicines (ointments, creams, sprays, liniments).

Do not apply a tight bandage while using the drug.

Influence on the ability to drive vehicles, mechanisms

The use of the drug does not affect the ability to perform potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, the work of a dispatcher and operator).

Product form

Gel for external use.

5 g per sachet. 30 g, 55 g and 110 g in plastic tubes. 452 g in bottles with a pump dispenser. 100 sachets along with instructions for medical use in a cardboard box. 1 plastic tube with instructions for medical use in a cardboard box. 1 bottle with a pump-dispenser, together with instructions for medical use, in a cardboard box.

Terms of dispensing from pharmacies

Without a prescription.

Storage conditions

Away from heat source and open flame at temperature not exceeding 25°C.

Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date.

Update date: 08/24/2020

Biofreeze instructions for use: indications, contraindications, side effects – description Biofreeze gel for external approx. 3.5g+0.2g/100g: pack. 5 g 100 pcs., tubes 30 g, 55 g or 110 g, vial. 452 g (31903)

📜 Instructions for use Biofreeze

💊 Ingredients of Biofreeze

✅ Use of Biofreeze

📅 Storage conditions Biofreeze

⏳ Expiry date Biofreeze

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Description of the medicinal product


Based on the approved prescribing information and prepared for the electronic edition of the Vidal Handbook 2012, update date: 2022. 05.30

Marketing authorization holder:





ATX Code:


(Other preparations)

Active ingredients

  • camphor
    European Pharmacopoeia
  • levomenthol
    Rec. INN
    WHO registered

Dosage form


Gel for outdoor approx. 3.5g+0.2g/100g: pack. 5 g 100 pcs., tubes 30 g, 55 g or 110 g, vial. 452 g

reg. No.: LP-000959
from 10/18/11
– Indefinitely

Date of re-registration: 03/13/17

Release form, packaging and composition

Topical gel clear, blue-green or green, with a menthol scent.

Excipients : Paraguayan holly extract – 5 g, isopropanol – 35 g, carbomer – 0.

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