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Menthol use. Menthol in Skin Wound Healing: Anti-Inflammatory and Antioxidant Properties

by alexxlab

How does menthol contribute to skin wound healing. What are the anti-inflammatory properties of menthol in wound care. How does menthol stimulate the antioxidant defense system. Can menthol increase epithelialization in skin wounds.

Содержание

The Healing Power of Menthol: A Comprehensive Overview

Menthol, a naturally occurring compound found in peppermint and other mint plants, has gained significant attention in the field of wound healing. This organic compound, known for its cooling and soothing properties, has demonstrated remarkable potential in promoting skin repair and regeneration. Recent studies have shed light on menthol’s multi-faceted role in wound healing, encompassing anti-inflammatory effects, antioxidant defense stimulation, and enhanced epithelialization.

The Chemical Nature of Menthol

Menthol is a cyclic terpene alcohol with the molecular formula C10H20O. Its unique structure allows it to interact with various cellular processes, making it a versatile compound in wound healing applications. The biosynthesis of menthol in plants involves a complex series of enzymatic reactions, primarily occurring in the essential oil glands of mint species.

Menthol’s Anti-Inflammatory Potential in Wound Healing

Inflammation is a crucial part of the wound healing process, but excessive or prolonged inflammation can impede proper healing. Menthol has shown promising anti-inflammatory properties that can help regulate this delicate balance.

Modulation of Inflammatory Mediators

How does menthol reduce inflammation in wounds? Menthol has been found to modulate the production and activity of various inflammatory mediators. It can suppress the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Additionally, menthol may inhibit the activation of nuclear factor kappa B (NF-κB), a key transcription factor involved in the inflammatory response.

TRPM8 Activation and Anti-Inflammatory Effects

Menthol is a known agonist of the transient receptor potential melastatin 8 (TRPM8) channel. Activation of TRPM8 by menthol has been linked to anti-inflammatory effects in various tissues, including the skin. This mechanism may contribute to reduced inflammatory cell infiltration and edema formation in wounds treated with menthol.

Stimulation of the Antioxidant Defense System

Oxidative stress plays a significant role in tissue damage during wound healing. Menthol’s ability to stimulate the antioxidant defense system offers a protective effect against this oxidative damage.

Enhancing Antioxidant Enzyme Activity

Can menthol boost antioxidant enzymes in wound healing? Studies have shown that menthol can enhance the activity of key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). These enzymes play crucial roles in neutralizing reactive oxygen species (ROS) and preventing oxidative damage to cells and tissues.

Scavenging Free Radicals

Beyond enzyme stimulation, menthol itself possesses free radical scavenging properties. Its molecular structure allows it to directly neutralize various types of free radicals, further contributing to the overall antioxidant defense in the wound environment.

Increased Epithelialization: Accelerating Wound Closure

Epithelialization is a critical phase in wound healing, involving the migration and proliferation of epithelial cells to cover the wound surface. Menthol has demonstrated the ability to enhance this process, potentially leading to faster wound closure.

Promoting Keratinocyte Migration

How does menthol affect keratinocyte behavior in wounds? Research has indicated that menthol can stimulate the migration of keratinocytes, the primary cell type in the epidermis. This enhanced migration contributes to more rapid re-epithelialization of the wound bed.

Modulating Matrix Metalloproteinases

Menthol may influence the activity of matrix metalloproteinases (MMPs), enzymes involved in extracellular matrix remodeling during wound healing. By modulating MMP activity, menthol could facilitate the restructuring of the wound environment, promoting efficient epithelialization.

Menthol’s Interaction with TRP Channels in Wound Healing

Transient receptor potential (TRP) channels play essential roles in various physiological processes, including wound healing. Menthol’s interaction with these channels contributes to its therapeutic effects.

TRPM8 and Pain Modulation

As mentioned earlier, menthol activates TRPM8 channels. This interaction not only contributes to anti-inflammatory effects but also plays a role in pain modulation. By activating TRPM8, menthol can induce a cooling sensation that may help alleviate pain associated with wounds.

TRPV3 and Nitric Oxide Synthesis

Interestingly, menthol has been found to interact with TRPV3 channels, which are involved in regulating nitric oxide (NO) synthesis in the skin. NO is a crucial signaling molecule in wound healing, influencing various aspects such as inflammation, angiogenesis, and collagen deposition. Menthol’s modulation of TRPV3 may contribute to optimized NO production during the healing process.

Formulations and Applications of Menthol in Wound Care

The therapeutic potential of menthol in wound healing has led to the development of various formulations and applications in wound care products.

Topical Ointments and Gels

Menthol is commonly incorporated into topical ointments and gels for direct application to wounds. These formulations often combine menthol with other wound-healing agents to create synergistic effects. The concentration of menthol in these products is carefully controlled to maximize therapeutic benefits while minimizing potential irritation.

Wound Dressings

Advanced wound dressings incorporating menthol have been developed to provide sustained release of the compound over time. These dressings may combine menthol with other materials such as hydrocolloids or alginates to create an optimal wound healing environment.

Potential Synergies with Other Natural Compounds

While menthol shows promise on its own, combining it with other natural compounds may enhance its wound healing properties.

Flavonoids and Menthol

Can flavonoids enhance menthol’s wound healing effects? Some studies have explored the combination of menthol with flavonoids, such as quercetin. These combinations may offer enhanced anti-inflammatory and antioxidant effects compared to either compound alone. The synergistic action could potentially accelerate wound healing and improve overall outcomes.

Essential Oils and Menthol

Essential oils from various plants have demonstrated wound healing properties. Combining menthol with essential oils like lavender or tea tree oil may provide complementary benefits, such as antimicrobial action and enhanced tissue regeneration.

Safety Considerations and Future Research Directions

While menthol shows great promise in wound healing, it’s essential to consider safety aspects and areas for future research.

Potential Skin Sensitization

Is menthol safe for all skin types? While generally well-tolerated, menthol can cause skin sensitization in some individuals. Future research should focus on identifying optimal concentrations and formulations that maximize therapeutic benefits while minimizing the risk of adverse reactions.

Long-Term Effects and Wound Remodeling

Most studies on menthol in wound healing have focused on the early stages of the process. Further research is needed to elucidate the long-term effects of menthol on wound remodeling and scar formation. Understanding these aspects will be crucial for developing comprehensive wound care strategies incorporating menthol.

In conclusion, menthol’s multifaceted role in wound healing, encompassing anti-inflammatory effects, antioxidant defense stimulation, and enhanced epithelialization, makes it a promising compound in the field of wound care. As research continues to uncover the intricacies of menthol’s mechanisms of action, we can expect to see more advanced and effective wound healing products incorporating this versatile natural compound. The integration of menthol into wound care strategies offers exciting possibilities for improving patient outcomes and accelerating the healing process.

The Use of Menthol in Skin Wound Healing—Anti-Inflammatory Potential, Antioxidant Defense System Stimulation and Increased Epithelialization

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Menthol Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). Menthol works by causing the skin to feel cool and then warm. These feelings on the skin distract you from feeling the aches/pains deeper in your muscles and joints.

How to use Menthol 5 % Topical Patch

Use this medication on the skin only. Clean and dry the affected area. Remove the backing from the patch and apply the patch to the affected area. Do not apply the patch to skin that is injured or irritated (such as skin that is cut, scraped, sunburned, infected, or has a rash). Leave the patch on the affected area for up to 12 hours. Use this medication as directed by your doctor or follow all directions on the product package. If you have any questions, talk to your doctor or pharmacist.

Take the patch off before bathing and do not apply the patch right after bathing. Do not bandage or wrap the area where the patch is applied unless directed to do so by the doctor. Do not apply heat (such as a heating pad) on the patch. Doing so may increase the risk of side effects.

Wash your hands well after handling the patch. Avoid getting this medication in your eyes, nose, or mouth. If you do get the medication in those areas, flush with plenty of water.

After removing each patch, fold the used patch with the sticky sides together, and throw away in the trash away from children and pets.

Tell your doctor if your condition lasts for more than 7 days, or if it gets worse, or if it keeps returning. If you think you may have a serious medical problem, get medical help right away.

Side Effects

Redness, mild itching, or irritation at the application site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop using this medication and tell your doctor right away if you have any serious side effects, including: blistering/swelling at the application site, increased/unusual pain at the application site.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this product, tell your doctor or pharmacist if you are allergic to menthol; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you are going to have an MRI test, tell testing personnel if you are using this patch. Some patches may contain metals that can cause serious burns during an MRI. Ask your doctor whether you will need to remove your patch before the test and apply a new patch afterward, and how to do so properly.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Menthol 5 % Topical Patch interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medication patch may be harmful if chewed or swallowed. If someone has overdosed, remove the patch if possible. For serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Keep all regular medical and lab appointments.

If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. (See also How to Use section.) Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Menthol – ingredient description, instructions for use, indications and contraindications
ProWellness

Table of contents

  • Description of menthol
  • Pharmacological properties of menthol
  • Use of menthol
  • Contraindications and side effects

Disclaimer

Please note that all information posted on the site
Prowellness is provided for informational purposes only and is not a personal program, a direct recommendation for action, or medical advice. Do not use these materials for diagnosis, treatment, or any medical procedure. Consult your physician before using any technique or using any product. This site is not a specialized medical portal and does not replace the professional advice of a specialist. The Site Owner is not liable to any party who has suffered indirect or direct damage as a result of misuse of materials posted on this resource.

Description of menthol

Menthol is an organic substance isolated from mint essence or produced synthetically. The compound is a secondary metabolite of plants belonging to the Lamiaceae family. It is a colorless crystal with a minty aroma and a cooling taste.

Menthol exhibits weak antiseptic activity, cools the skin and mucous membranes, and has a local anesthetic effect. It is included in the formulation of the vasodilator drug Validol.

Pharmacological properties of menthol

Menthol has the following properties:

  • relieves the symptoms of diseases of the mouth and throat;
  • exhibits antimicrobial activity;
  • suppresses inflammatory processes;
  • reduces the severity of pain;
  • eliminates itching;
  • constricts blood vessels;
  • tones the veins;
  • is an effective analgesic;
  • relieves migraine attacks;
  • has a carminative effect;
  • lowers pressure;
  • calms the central nervous system;
  • excites the trigeminal nerve;
  • cools at high body temperature, warms at low body temperature.

Attention! Menthol improves potency. However, when the drug is abused, it has the opposite effect. Therefore, you must strictly adhere to the instructions for its use.

The use of menthol

Menthol is used in the complex therapy of gastrointestinal pathologies. It stimulates appetite, normalizes digestion and eliminates nausea. With colds, the drug acts as an anesthetic and reduces the frequency and severity of coughing attacks.

In liquid form, menthol is used to lubricate sore tonsils and gums. Menthol ointment for the joints suppresses inflammation, and for the legs – cools, dulls pain, relieves spasms.

Menthol inhalation helps to cure a runny nose and reduce the viscosity of sputum. When using a solution of menthol in combination with valerian tincture, a calming effect can be achieved. This combination is used for cardiac pathologies, for example, with angina attacks.

Menthol oil is used for weakness, overexcitation. The remedy is indicated for allergic skin reactions, dermatitis and other rashes. The cooling effect of menthol helps to reduce itching and irritation.

Contraindications and side effects

Menthol is contraindicated in the following conditions:

  • under 5 years of age;
  • complications of varicose veins;
  • extensive dermatitis;
  • individual intolerance;
  • allergy.

Adverse reactions possible. The most common ingestion is nausea, vomiting, pain in the abdomen. When applied externally, drowsiness, dizziness, and impaired coordination of movements may occur.

Disclaimer

Please note that all information posted on the site
Prowellness is provided for informational purposes only and is not a personal program, a direct recommendation for action, or medical advice. Do not use these materials for diagnosis, treatment, or any medical procedure. Consult your physician before using any technique or using any product. This site is not a specialized medical portal and does not replace the professional advice of a specialist. The Site Owner is not liable to any party who has suffered indirect or direct damage as a result of misuse of materials posted on this resource.

Menthol Food Flavor

Frequently Asked Questions:

WHERE CAN YOUR FLAVOR BE USED?

In the food industry: in the production of milk-containing products, non-alcoholic and low-alcohol drinks, confectionery, bakery products, ice cream, fatty products, fillers, fillings, sauces, food concentrates, flavored teas

WHAT DOSAGE / CONSUMPTION OF YOUR FLAVORS?

Recommended dosage g/kg:
0.5-0.6 – marmalade
1.0-1.2 – fruit fillings
1.5-2.0 – caramel
0.5-1.0 – dairy products
0.4-0, 6 – soft drinks
0. 8-1.0 – milk-based ice cream
1.8-2.0 – flour products

The working dosage of flavoring in a particular product is selected by the manufacturer in the process of testing on specific recipes.

How to use your fragrance?

Flavor can be added separately, directly to the product, or mixed with liquid components (oil, water, juices) during preparation.

How safe are your fragrances?

Flavors comply with the requirements of TR CU 029/2012, TU 9154-001-75419099-2006.
Uniform sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision and (control).
This product does not contain additives containing genetically modified organisms (GMOs), as well as substances according to clause 21, art. 7 TR CU 029/2012.

What is the shelf life of your fragrances?

Not more than 24 months, in original unopened packaging, in dry, dark closed rooms at a temperature not exceeding 25°C and not lower than 0°C.

what is the composition of your fragrances?

Flavors consist of natural sources of flavoring substances and flavoring preparations made from them according to TR CU 029/2012.

Menthol has pronounced antiseptic and anti-inflammatory properties

The widespread use of menthol has already become traditional. We meet products with this fresh and invigorating aroma among cosmetics, food, medicines. Well, menthol-flavored candy or chewing gum is a favorite delicacy of many. I wonder what is menthol? It turns out that this natural food essence is extracted from a plant familiar to us – mint. Almost all liquid food flavors presented in the assortment on our website are made from natural ingredients.

Just a few mint leaves are enough to add an invigorating and refreshing effect to ordinary tea. Menthol also has pronounced antiseptic and anti-inflammatory properties. To emphasize the taste and aroma of most culinary products, especially sweets and desserts, production technologists add Menthol food flavoring.