What are the uses of methylcobalamin. How does methylcobalamin treat vitamin B12 deficiency. What are the potential side effects of taking methylcobalamin. When should you consult a doctor before using methylcobalamin. How is methylcobalamin administered for optimal absorption.

Understanding Methylcobalamin: A Crucial Form of Vitamin B12

Methylcobalamin is a bioactive form of vitamin B12 that plays a vital role in maintaining overall health and well-being. As an essential nutrient, it supports various bodily functions, including the formation of red blood cells, nervous system health, and DNA synthesis. Unlike other forms of B12, methylcobalamin is readily available for the body to use, making it an efficient choice for supplementation.

This potent vitamin is particularly important for individuals with B12 deficiency, a condition that can lead to serious health complications if left untreated. Understanding the uses, benefits, and potential side effects of methylcobalamin is crucial for anyone considering supplementation or currently taking this vitamin.

The Therapeutic Applications of Methylcobalamin

Methylcobalamin is primarily used to address vitamin B12 deficiency, but its applications extend beyond this fundamental role. Here are some key therapeutic uses:

• Treating pernicious anemia
• Supporting diabetic neuropathy management
• Enhancing cognitive function
• Promoting nervous system health
• Aiding in the production of red blood cells

For individuals with conditions that impair B12 absorption, such as those with gastric bypass surgery or certain autoimmune disorders, methylcobalamin supplementation can be life-changing. It provides the body with a form of B12 that bypasses some of the usual absorption barriers in the digestive system.

How does methylcobalamin differ from other forms of B12?

Methylcobalamin stands out from other B12 forms like cyanocobalamin due to its methylated structure. This means it’s already in a form that the body can immediately use, potentially making it more effective for certain individuals. Additionally, it doesn’t require the body to remove and excrete a cyanide molecule, as is the case with cyanocobalamin.

Administering Methylcobalamin: Routes and Recommendations

The administration of methylcobalamin can vary depending on the individual’s needs and the severity of their deficiency. Common routes of administration include:

1. Oral tablets or capsules
2. Sublingual lozenges or tablets
3. Intramuscular injections

Oral methylcobalamin is often the first choice for mild deficiencies or maintenance therapy. Sublingual forms are popular because they allow for direct absorption through the mucous membranes under the tongue, potentially bypassing some digestive issues. For severe deficiencies or conditions that significantly impair absorption, intramuscular injections may be necessary to rapidly restore B12 levels.

What is the recommended dosage for methylcobalamin?

Dosage recommendations can vary widely based on individual needs and the condition being treated. Typical oral doses range from 500 mcg to 5000 mcg daily. However, it’s crucial to consult with a healthcare provider to determine the appropriate dosage, as excessive intake may mask underlying health issues or lead to adverse effects.

Potential Side Effects and Precautions

While methylcobalamin is generally considered safe, some individuals may experience side effects. Common side effects include:

• Nausea and vomiting
• Diarrhea
• Headache
• Loss of appetite

In rare cases, more severe reactions can occur, such as allergic reactions characterized by hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. If any of these symptoms occur, immediate medical attention should be sought.

Are there any contraindications for methylcobalamin use?

Certain individuals should exercise caution or avoid methylcobalamin unless under strict medical supervision. These include people with:

• Leber’s disease or other forms of optic nerve damage
• Iron or folic acid deficiency
• Low potassium levels in the blood

Additionally, individuals with a history of allergic reactions to vitamin B12 or cobalt should not use methylcobalamin.

Drug Interactions and Considerations

Methylcobalamin can interact with several medications, potentially affecting their efficacy or increasing the risk of side effects. Some notable interactions include:

• Chloramphenicol (an antibiotic)
• Colchicine
• Metformin and other oral diabetes medications
• Proton pump inhibitors and H2 blockers (acid-reducing medications)

It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking before starting methylcobalamin supplementation. This ensures that potential interactions can be identified and managed appropriately.

How does alcohol consumption affect methylcobalamin absorption?

Excessive alcohol intake can interfere with the body’s ability to absorb and utilize methylcobalamin effectively. Chronic heavy drinking may lead to B12 deficiency, even in individuals taking supplements. Therefore, it’s advisable to limit alcohol consumption and discuss any concerns about alcohol use with a healthcare provider.

Special Populations and Methylcobalamin Use

Certain groups may have unique considerations when it comes to methylcobalamin supplementation:

Pregnancy and Breastfeeding

Adequate B12 intake is crucial during pregnancy and lactation for fetal development and infant health. However, pregnant or breastfeeding individuals should consult their healthcare provider before starting any new supplement regimen, including methylcobalamin.

Children

Methylcobalamin supplementation in children should only be done under medical supervision. The dosage and necessity of supplementation can vary greatly depending on the child’s age, diet, and health status.

Vegetarians and Vegans

Plant-based diets often lack natural sources of B12, making supplementation particularly important for vegetarians and vegans. Methylcobalamin can be an excellent choice for these individuals, as it’s typically derived from non-animal sources.

Monitoring and Maintaining Optimal B12 Levels

Regular monitoring of B12 levels is essential for individuals taking methylcobalamin supplements, especially those with chronic deficiencies or absorption issues. Blood tests can help determine if the current dosage is adequate or if adjustments are needed.

What are the signs of B12 deficiency?

Symptoms of B12 deficiency can be subtle and develop gradually. Common signs include:

• Fatigue and weakness
• Pale or jaundiced skin
• Shortness of breath
• Dizziness
• Mood changes or depression
• Memory problems
• Tingling or numbness in extremities

If you experience any of these symptoms, it’s important to consult a healthcare provider for proper evaluation and treatment.

Future Research and Potential Applications

The field of B12 research continues to evolve, with ongoing studies exploring new potential applications for methylcobalamin. Areas of interest include:

• Neuroprotective effects in neurodegenerative diseases
• Role in sleep regulation and circadian rhythms
• Potential benefits in cardiovascular health
• Impact on mood disorders and mental health

As research progresses, our understanding of methylcobalamin’s role in health and disease prevention may expand, potentially leading to new therapeutic applications and improved supplementation strategies.

How might methylcobalamin research impact future healthcare practices?

Advancements in methylcobalamin research could lead to more targeted supplementation protocols, personalized dosing regimens, and potentially new treatment modalities for conditions associated with B12 deficiency or metabolism. This could result in more effective prevention and management of various health issues, from neurological disorders to cardiovascular diseases.

In conclusion, methylcobalamin plays a crucial role in maintaining overall health and treating vitamin B12 deficiency. Its unique properties make it an effective supplement for many individuals, particularly those with absorption issues. However, as with any supplement, it’s essential to use methylcobalamin under proper medical guidance, considering individual health needs, potential interactions, and appropriate dosing. By understanding the benefits, risks, and proper use of methylcobalamin, individuals can make informed decisions about their health and potentially improve their quality of life through optimal B12 supplementation.

Methylcobalamin vitamin B12 Uses, Side Effects & Warnings

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Generic name: methylcobalamin (vitamin B12) oral/injection [ METH-il-koe-BAL-a-min ]
Brand names: Methyl B-12, Vitamin B12 Methylcobalamin
Dosage forms: injectable solution (1 mg/mL; 10 mg/mL; 5 mg/mL), oral capsule (2000 mcg), oral lozenge (1 mg; 500 mcg), oral tablet, disintegrating (1 mg), sublingual tablet (5000 mcg)
Drug class: Vitamins

Medically reviewed by Drugs.com on Sep 28, 2022. Written by Cerner Multum.

What is methylcobalamin?

Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells.

Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions.

Methylcobalamin may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use methylcobalamin if you are allergic to vitamin B12 or cobalt.

Tell your doctor if you have ever had:

• Leber’s disease or other form of optic nerve damage;

• an iron or folic acid deficiency; or

• low levels of potassium in your blood.

Tell your doctor if you are pregnant or breastfeeding.

Do not give methylcobalamin to a child without medical advice.

How should I use methylcobalamin?

Use exactly as directed on the label, or as prescribed by your doctor.

Methylcobalamin oral is taken by mouth.

Methylcobalamin injection is injected into a muscle, usually 1 to 3 times per week. A healthcare provider can teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions.

Do not swallow a lozenge, disintegrating tablet, or sublingual tablet whole. Allow it to dissolve in your mouth without chewing. The sublingual tablet should be placed under your tongue.

Your dose needs may change if you become pregnant, if you breastfeed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.

For more information you may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Dietary Reference Intakes (formerly “Recommended Daily Allowances”) listings for more information.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking methylcobalamin?

Avoid drinking large amounts of alcohol. Heavy drinking can make it harder for your body to absorb methylcobalamin.

Methylcobalamin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of methylcobalamin may include:

• nausea, vomiting, diarrhea;

• loss of appetite; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect methylcobalamin?

Tell your doctor about all your other medicines, especially:

• chloramphenicol;

• colchicine

• antibiotic medicine;

• oral diabetes medicine that contains metformin; or

• medicines that reduce stomach acid, such as cimetidine, omeprazole, lansoprazole, Nexium, Prevacid, Prilosec, Zantac, and others.

This list is not complete. Other drugs may affect methylcobalamin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about methylcobalamin

• Check interactions
• Compare alternatives
• Reviews (2)
• Side effects
• Drug class: vitamins

Patient resources

• Patient Information

Professional resources

• Advanced Reading

Related treatment guides

• Dietary Supplementation

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01.

Causes, Symptoms and Treatment Options

Medically reviewed by Drugs.com. Last updated on Mar 24, 2023.

What is Anemia?

Anemia is an abnormally low level of red blood cells.

Red blood cells contain hemoglobin. Hemoglobin is a protein that carries oxygen in the blood.

Red blood cells are produced in the bone marrow and then released into the bloodstream. Normally, they live for 110 to 120 days. Older red blood cells are removed from the blood by the spleen and liver.

Anemia can occur when the bone marrow does not produce enough red blood cells to replace those that have died. Or it can occur if the red blood cells die or are destroyed more quickly than usual.

Reasons for under-production of red blood cells by the bone marrow include:

• iron deficiency caused by inadequate intake, blood loss, or poor absorption from the intestine
• vitamin B₁₂ deficiency from either a strict vegetarian diet or an inability to absorb vitamin B₁₂ (known as pernicious anemia).
• some infections, such as parvovirus infection
• chronic diseases, especially inflammatory diseases such as rheumatoid arthritis
• a side effect of some medications, especially chemotherapy
• a disease of the bone marrow, such as aplastic anemia.

When red blood cells are destroyed too quickly, it’s known as hemolytic anemia. This can happen when:

• red blood cells have an abnormally short life span
• there is something wrong with the red blood cells
• the red blood cells are normal but are destroyed by an external process.

Causes of hemolytic anemia include:

• inherited abnormalities of red blood cells, such as sickle cell anemia
• physical damage to red blood cells, which can occur, for example, during heart bypass surgery or as the blood flows through artificial heart valves
• autoimmune hemolytic anemia, a condition in which the body’s immune system mistakenly destroys its own red blood cells
• an enlarged and overactive spleen (hypersplenism), which can trap circulating red blood cells and destroy them before they are old.

Symptoms

Symptoms vary widely. Mild cases often don’t cause any symptoms. The condition may only be discovered during a routine blood test.

In other people, obvious symptoms of anemia can develop. These include:

• pale skin
• fatigue
• weakness
• dizziness
• lightheadedness
• breathlessness.

Diagnosis

Your doctor will review your medical history. He or she will ask you to describe your symptoms.

During your physical examination, your doctor will look for signs of anemia. These include:

• pale skin and fingernails
• rapid pulse
• heart murmur
• enlarged spleen and liver.

This exam will be followed by blood tests to

• measure the levels of red blood cells
• look at the size and shape of red blood cells
• measure the hemoglobin level
• determine the number of immature red blood cells (the bone marrow may pour out immature blood cells in an effort to make up for the anemia).

Your doctor may also order tests to check for blood in your stool. This can identify whether your anemia is caused by blood loss. Other blood tests check for anemia resulting from a lack of iron or certain vitamins in your diet.

Any other tests you may receive will depend on the suspected cause of your anemia.

Expected duration

How long anemia lasts depends on its cause and how easily it can be corrected. If the reason for the anemia is only inadequate intake of iron or vitamin B₁₂, the anemia will start to correct within days of treatment.

Anemia caused by an inherited illness is a lifelong condition. Its impact on a person’s quality of life and life span can vary greatly, and depends on the specific inherited disorder and its severity. Some people don’t have any symptoms. Others have severe, persistent symptoms.

Prevention

Anemia caused by nutritional deficiency can be prevented by eating a healthy diet or taking a vitamin and mineral supplement when iron or B₁₂ intake might be insufficient.

Most other types of anemia cannot be prevented.

Treatment

Treatment of anemia depends on its severity and cause. Severe anemia may require blood transfusion.

Iron and vitamin B₁₂ deficiency require supplements, which are usually taken by mouth.

Anemia caused by a drug is treated by stopping the drug.

Autoimmune hemolytic anemia is usually treated with drugs called corticosteroids first. Other therapies are added if needed.

Inherited hemolytic anemia may require removal of the spleen (a procedure called splenectomy).

Treatment options

The following list of medications are in some way related to or used in the treatment of this condition.

• epoetin alfa
• Procrit
• Vitamin B6
• Reblozyl
• Epogen

View more treatment options

When to call a professional

Call your doctor promptly if you develop symptoms of anemia. Also call if you notice a yellowish tint to your skin or in the whites of your eyes.

If an inherited form of anemia runs in your family, you may wish to consider genetic testing before you start a family.

Prognosis

The outlook for anemia depends on its cause and severity, as well as the underlying health of the affected person.

Cases that are caused by medications or infections usually go away quickly. Anemia caused by chronic diseases tends to be persistent, but is rarely severe.

People with autoimmune hemolytic anemia usually respond well to treatment.

The outlook for people with inherited anemias depends on the type of inherited illness and its severity.

National Heart, Lung, and Blood Institute (NHLBI)

www.nhlbi.nih.gov/

Learn more about Anemia

Treatment options

• Medications for Anemia
• Medications for Pernicious Anemia

Care guides

• Anemia

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Methylcobalamin/Vitamin B12 2500 mcg 60 tabs

Swanson™ Methylcobalamin/Vitamin B12 2500 mcg

Quantity: 60 tabs.

Swanson™ Methylcobalamin / Vitamin B-12 2500 mcg. is an advanced formula vitamin containing Methylcobalamin which is the active form of vitamin B-12 . Unlike other forms of vitamin B-12, this active form does not need to be converted in the human body before the vitamin can work.

Vitamins B-12:

• Needed for energy production†
• Supports a healthy nervous system †
• Supports healthy brain function †
• Due to their rapid absorption, these vitamins can replace injections

Today’s active lifestyle requires a lot of energy. Every day we are forced to follow a tight schedule, and also have some energy in reserve for what we love to do. Such a pace of life requires a significant amount of energy, and therefore, essential vitamin supplements, such as vitamin B-12. † Maintaining adequate levels of Vitamin B-12 in the body is vital to our health, as Vitamin B-12 is a key vitamin in our body’s enzymatic processes and is essential for the body to function properly to keep the nervous system and brain functioning properly. It helps keep us in good shape. †

Vitamin B12 is known to become less effective with age, so it is recommended that vitamin B12 be taken as a daily supplement by persons over 50 years of age. Vitamin B12 is also recommended for vegetarians, as vitamin B12 is mainly found in animal products.

Features of the formula of these vitamins:

• Rapid absorption by the body
• High Bioavailability Formula Methylcobalamin B-12
• Excellent cherry flavor.

These vitamins use an advanced formula that provides high bioavailability of methylcobalamin , in the form of vitamin B-12. This is an active form B-12 and should not be converted. Therefore, sublingual tablets ensure optimal transfer of vitamin B-12 to the human body. Also, sublingual tablets of vitamin B-12 5000 mcg . can replace injections of of this vitamin.

Other Ingredients: Xylitol, microcrystalline cellulose (plant fiber), croscarmellose sodium, crospovidone, carboxymethylcellulose, citric acid, natural cherry flavor, hydroxypropyl cellulose, hydroxypropyl methylcellulose, calcium palmitate, silica, vegetable juice color [gum rabik, vegetable juice ( Beetroot, Black Carrot, Purple Sweet Potato, Red Cabbage, Red Radish), Maltodextrin, Citric Acid], Stevia Extract (Stevia rebaudiana) (leaf).

Recommended Use:

Take 1-2 tablets per day by placing under the tongue for 30 seconds and then swallowing. USP Verified

This drug has been verified by the United States Pharmacopeia (USP), which is an independent, scientific, non-profit organization that sets strict quality and purity standards for nutritional supplements manufactured and distributed throughout the world.

Our Commitment to Delivering Quality and Value

Since 1969, the Swanson™ brand has been providing high quality nutritional supplements and has earned high praise from customers in that time. Swanson™ vitamins, minerals and supplements are made from carefully selected ingredients sourced from trusted suppliers.

Additives are manufactured in accordance with good manufacturing practices. In addition, many of the ingredients listed above are tested by the United States Pharmacopeia (USP), which is an independent, scientific, non-profit organization that sets strict quality and purity standards for dietary supplements.

Made in USA

OstroVit Vitamin B12 Methylcobalamin 200 tablets

Product form:

tablets

Servings:

800

Pieces:

200

9000 4 Net weight:

38 g

Dominant component:

vitamin B12

EAN -code:

5903933

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OstroVit Vitamin B12 Methylcobalamin 200 tablets

OstroVit Vitamin B12 Methylcobalamin is a dietary supplement from the line of professional vitamins. The product is intended for everyone who wants to supplement their daily diet with vitamin B12.

Vitamin B12 Methylcobalamin

Methylcobalamin is the biologically active form of vitamin B12 recommended for all people who are struggling with the absorption of the non-methyl forms of the vitamin most commonly found in supplements. Methylcobalamin is easily absorbed, stays in tissues longer and does not contain harmful cyanide. Unlike the synthetic form of vitamin B12, it does not convert to methyl directly in the body.

OstroVit Properties Vitamin B12 Methylcobalamin:

• COMPLEX EFFECT – Without enough vitamin B12, our body cannot function properly. Vitamin B12 supports the production of red blood cells and also affects the nervous system, thereby helping you maintain memory and concentration.
• METHYLCOBALAMIN VITAMIN – Methylcobalamin is the best form of vitamin B12 on the market. Compared to the commonly used cyanocobalamin tablets, it is absorbed faster and stays in the body longer. This is a ready-made active substance that does not transform into a simpler form.
• HIGH DOSE – One OstroVit supplement tablet contains 400 micrograms of vitamin B12, equal to four daily doses. With regular use, a package of this supplement lasts for many months.
• VEGAN PRODUCT – If you are a vegetarian, vegan, or rarely eat meat or animal products, vitamin B12 is recommended.

How to use

Take 1 serving (1/4 tablet) per day. This product is intended for adults.

Do not exceed the recommended daily allowance. A food supplement should not be used as a substitute for a varied diet.