What are the primary uses of Monovisc. How does Monovisc work to alleviate osteoarthritis symptoms. What are the potential side effects of Monovisc injections. When should patients avoid using Monovisc. How is Monovisc administered and what precautions should be taken.

Understanding Monovisc: A Breakthrough in Osteoarthritis Treatment

Monovisc is an innovative medical solution designed to address the challenges posed by osteoarthritis, a debilitating condition affecting millions worldwide. This injectable treatment offers hope to those who have not found relief through conventional therapies, providing a unique approach to joint pain management.

What is Monovisc?

Monovisc is a high molecular weight hyaluronic acid injection used primarily for treating osteoarthritis-related pain. It belongs to a class of treatments known as viscosupplements, which aim to improve joint lubrication and reduce inflammation.

The Science Behind Monovisc

At its core, Monovisc contains sodium hyaluronate, a naturally occurring substance in the human body. This compound plays a crucial role in maintaining the viscosity of joint fluid, which is essential for smooth joint movement and shock absorption.

Key Benefits and Uses of Monovisc

Monovisc offers several advantages in the treatment of osteoarthritis, particularly for patients who have not responded well to other forms of therapy. Here are some of the primary benefits:

• Effective pain relief for osteoarthritis sufferers
• Improved joint mobility and function
• Reduced inflammation in the affected joint
• Potential to delay or prevent more invasive procedures like joint replacement surgery

Is Monovisc Suitable for All Types of Arthritis?

While Monovisc is primarily indicated for osteoarthritis, its effectiveness in other forms of arthritis may vary. It’s crucial to consult with a healthcare professional to determine if Monovisc is appropriate for your specific condition.

The Monovisc Administration Process: What to Expect

Understanding the administration process of Monovisc can help alleviate any concerns patients might have about the treatment. Here’s what you need to know:

1. Monovisc is administered via intra-articular injection
2. The procedure is typically performed by a qualified healthcare professional
3. A single injection is usually sufficient for a treatment course
4. The entire process generally takes less than 30 minutes

How Long Does It Take for Monovisc to Start Working?

The onset of relief after a Monovisc injection can vary among individuals. Some patients report improvement within a few days, while others may take several weeks to experience the full benefits. Patience is key, as the effects of Monovisc can continue to improve over time.

Potential Side Effects and Precautions

As with any medical treatment, Monovisc comes with potential side effects. While most are mild and temporary, it’s important to be aware of possible reactions:

• Injection site reactions (pain, swelling, redness)
• Temporary increase in joint pain or stiffness
• Muscle pain
• Rare allergic reactions

Who Should Avoid Monovisc?

Monovisc may not be suitable for everyone. Patients with the following conditions should consult their doctor before considering this treatment:

• Active joint infections
• Skin diseases or infections near the injection site
• Known allergies to hyaluronic acid products
• Severe bleeding disorders

Comparing Monovisc to Other Osteoarthritis Treatments

In the landscape of osteoarthritis treatments, Monovisc stands out for several reasons. Let’s compare it to some common alternatives:

Monovisc vs. Oral Pain Medications

Unlike oral pain medications, Monovisc targets the affected joint directly, potentially reducing systemic side effects. It also offers longer-lasting relief compared to daily pain medications.

Monovisc vs. Corticosteroid Injections

While corticosteroid injections provide rapid pain relief, their effects are often short-lived. Monovisc, on the other hand, aims to provide more sustained relief and may have fewer long-term side effects.

Monovisc vs. Other Viscosupplements

Monovisc’s single-injection protocol sets it apart from many other viscosupplements that require multiple injections. This can mean fewer office visits and potentially less discomfort for patients.

Lifestyle Considerations When Using Monovisc

To maximize the benefits of Monovisc treatment, consider the following lifestyle adjustments:

• Avoid strenuous activities for 48 hours post-injection
• Incorporate low-impact exercises to support joint health
• Maintain a healthy weight to reduce stress on joints
• Follow a balanced diet rich in anti-inflammatory foods

Can Monovisc Be Combined with Other Treatments?

In many cases, Monovisc can be used in conjunction with other osteoarthritis treatments. However, it’s essential to discuss any combination therapy with your healthcare provider to ensure safety and efficacy.

Long-Term Outlook: What to Expect from Monovisc Treatment

The long-term effectiveness of Monovisc can vary among individuals. Some key points to consider:

• Effects typically last 4-6 months, but can extend up to a year for some patients
• Repeat treatments may be necessary to maintain relief
• Regular follow-ups with your healthcare provider can help monitor progress and adjust treatment as needed

Does Monovisc Slow the Progression of Osteoarthritis?

While Monovisc primarily focuses on symptom relief, some studies suggest it may have a protective effect on cartilage. However, more research is needed to definitively conclude its impact on disease progression.

Insurance Coverage and Cost Considerations for Monovisc

The financial aspect of Monovisc treatment is an important consideration for many patients. Here’s what you need to know:

• Coverage varies among insurance providers
• Some plans may require prior authorization or proof of failure with other treatments
• Out-of-pocket costs can be significant without insurance coverage
• Patient assistance programs may be available for those who qualify

How to Navigate Insurance Approval for Monovisc

To increase the likelihood of insurance approval, work closely with your healthcare provider to document your osteoarthritis history, previous treatments, and the medical necessity for Monovisc. Be prepared to appeal if initially denied coverage.

Future Developments: The Evolving Landscape of Osteoarthritis Treatment

As research in osteoarthritis treatment continues to advance, new developments may impact the use of Monovisc and similar treatments. Stay informed about:

• Emerging combination therapies
• Advancements in hyaluronic acid formulations
• Potential for personalized treatment approaches
• Ongoing clinical trials exploring new applications for viscosupplements

Will Monovisc Be Replaced by New Technologies?

While new technologies are constantly emerging, Monovisc’s established safety profile and effectiveness suggest it will remain a valuable treatment option for the foreseeable future. However, it may be used in conjunction with newer therapies as they become available.

In conclusion, Monovisc represents a significant advancement in the treatment of osteoarthritis, offering hope to many who suffer from this debilitating condition. As with any medical treatment, it’s crucial to discuss the potential benefits and risks with your healthcare provider to determine if Monovisc is the right choice for your individual needs. By staying informed and working closely with your medical team, you can make the most of this innovative treatment and potentially improve your quality of life.

Monovisc: Uses, Side effects, Reviews, Composition, Expert Advice and Precautions

About Monovisc Products

Sodium Hyaluronate is used in the treatment of dry eyes.

Common

Limited data available.

Severe

Side Effects of Monovisc are Stinging in the eyes, Burning sensation in eye, Eye irritation, Foreign body sensation, Scratch dermatitis, Increased production of tears, Eye discharge, Eye redness, Reduced visual acuity, Blurred vision, Halo vision, Photophobia.

Sodium Hyaluronate is a lubricant. It moistens the eyes and provides temporary relief from burning and discomfort.

Patient Concerns about Monovisc Products

Frequently asked questions about Monovisc Products

Q. Can Monovisc 88mg Injection blur the vision?

Yes, some patients may experience blurring of vision, but it is temporary and passes away quickly. It is recommended that after instilling the eye drops, blink your eyes several times to spread it over the eye surface.

Q. What is Monovisc 88mg Injection?

Monovisc 88mg Injection is a naturally occurring substance in the body and is also present in the eye. Monovisc 88mg Injection eye drops are basically artificial tears which are required when there is a deficiency of hyaluronic acid in the eyes.

Q. What is Monovisc 88mg Injection used for?

Monovisc 88mg Injection is used for the treatment of dry eye syndrome (keratoconjunctivitis sicca). In addition to treating dryness, it is also helpful in protecting eyes. It is also used to treat dryness of cornea caused by trauma to it or when the eyes cannot be closed due to nerve paralysis.

Q. How do you use Monovisc 88mg Injection?

You should use Monovisc 88mg Injection exactly as directed by your doctor. Do not touch the tip of the container and avoid it coming in contact with eye or eyelid. After opening the eyelid, instil 1-2 drops in the eye with someone’s help. To prevent washout, try to avoid using any eye drop/eye ointment for 15 minutes at least.

Q. I wear contact lenses, can I use Monovisc 88mg Injection?

Yes, Monovisc 88mg Injection can be used with contact lenses. However, your doctor will tell you whether you can use eye drops while wearing the contact lenses or you need to take out contact lenses and then instil the drops.

Q. How often can you use Monovisc 88mg Injection?

It is recommended to use Monovisc 88mg Injection 4 times a day or you can use it more than 4 times if your doctor has advised you, based on your eye condition.

Q. How long do I need to use Monovisc 88mg Injection?

Continue using Monovisc 88mg Injection as long as your doctor has recommended. The time duration will depend on your eye condition. It can be used for an extended period of time, if required.

Information last updated by Dr. Varun Gupta, MD Pharmacology on 11th May 2023.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.

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Monovisc 88mg Injection: View Uses, Side Effects, Price and Substitutes

Product introduction

Monovisc 88mg Injection is a medicine used for treatment of pain due to osteoarthritis. This medicine is commonly given when when a patient does not respond to other conventional treatments. It reduces the friction in the joints and decreases the pain and swelling.

Monovisc 88mg Injection is administered by intra‐articular injection. Intra‐articular injection is given by inserting a needle into the space in the knee joint that contains fluid used for lubrication and cushioning. it should not be self-administered as it can be only administered by a qualified doctor. While on treatment with this medicine, you should avoid activities such as strenuous sports and exercise, or standing on your feet for a long time.

Some common side effects of this medicine include injection site reactions (such as pain, swelling, and redness), muscle pain, and joint pain. If these side effects do no resolve with time or get worse, you should let your doctor know. Your doctor may help with ways to reduce or prevent these symptoms by prescribing you alternative medicine or adjusting the dose.

You should not take this medicine if you have a knee joint infection or skin disease, or infection  around the area where the injection will be given. To make sure the medicine is safe for you, let your doctor know if you have any problems with your heart, kidneys, or liver. You should also let your doctor know all the other medicines you are taking before using this medicine. If you are pregnant or breastfeeding, consult your doctor first before taking this medicine.

Uses of Monovisc Injection

• Treatment of Osteoarthritis

Benefits of Monovisc Injection

In Treatment of Osteoarthritis

Osteoarthritis is a condition that causes pain and swelling in the joints of your hands, knees, hips and spine. Monovisc 88mg Injection is most commonly used to treat knee pain caused by osteoarthritis. Monovisc 88mg Injection helps restore the synovial fluid which helps in lubricating and cushioning the joint during movement. This way it restores the mobility and reduce the pain. Mild symptoms of osteoarthritis can sometimes be managed by doing light exercises, losing weight and suitable footwear.

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Monovisc

• Injection site reactions (pain, swelling, redness)
• Muscle pain
• Joint pain

How to use Monovisc Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Monovisc Injection works

Monovisc 88mg Injection is the salt form of hyaluronic acid. It helps supplement the viscous properties of the fluid in knee joint thereby reducing friction in the joints and helps them work smoothly.

Safety advice

Alcohol

SAFE

Consuming alcohol with Monovisc 88mg Injection does not cause any harmful side effects.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Monovisc 88mg Injection during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Monovisc 88mg Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Monovisc 88mg Injection does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Monovisc 88mg Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Monovisc 88mg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Monovisc Injection?

If you miss a dose of Monovisc 88mg Injection, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Fact Box

Chemical Class

Nonsulfated Glycosaminoglycan

Habit Forming

No

Therapeutic Class

OPHTHAL

Action Class

Osteoarthritis- Hyaluronic acid

Patient concerns

Rheumatoid arthritis with osteoarthritis

Dr. Akshat Goel

Orthopaedics

Please refer to a Rheumatologist

MORE

Feeling pain due to osteoarthritis

Vipul Aggarwal

Send me the X-rays please

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Osteoarthritis curable medicine n treatment

Dr. Akshat Goel

Orthopaedics

Get a Digital x-ray done of Both knees AP-view in standing position and share itAsk your treating doctor about Hyaluronic acid injections in knee

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What is the treatment of osteoarthritis

Dr. Akshat Goel

Orthopaedics

Depends upon The stage of the disease

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Osteoarthritis knee joints both sides

Dr. Akshat Goel

Orthopaedics

get a Digital x-ray done of Both knees AP-view in standing position and share it

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Osteoarthritis problem for 3 yrs

Vipul Aggarwal

send me the X-rays please

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Low back pain and osteoarthritis

Dr. Akshat Goel

Orthopaedics

Avoid forward bending and Avoid lifting heavy weight Do Hot Fomentation and apply Dynapar QPS spray and take Tab Myospas-D thrice daily and Tab Flotrip-forte thrice daily and Cap Nurokind-Gold twice daily Do Spinal Extension exercises

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How effective s glucosamine in osteoarthritis ?

Dr. Mehtab Baig

Orthopaedic Physiotherapy

It’s effects on you cartilage and lubricants for ur all joints

MORE

User feedback

What are you using Monovisc Injection for?

Osteoarthriti*

100%

*Osteoarthritis

How much was the improvement?

Excellent

100%

What were the side-effects while using Monovisc 88mg Injection?

No Side Effec*

100%

*No Side Effect

How do you take Monovisc Injection?

With food

100%

Please rate Monovisc 88mg Injection on price

Average

100%

FAQs

Q.

Can Monovisc 88mg Injection blur the vision?

Yes, some patients may experience blurring of vision, but it is temporary and passes away quickly. It is recommended that after instilling the eye drops, blink your eyes several times to spread it over the eye surface.

Q. What is Monovisc 88mg Injection?

Monovisc 88mg Injection is a naturally occurring substance in the body and is also present in the eye. Monovisc 88mg Injection eye drops are basically artificial tears which are required when there is a deficiency of hyaluronic acid in the eyes.

Q. What is Monovisc 88mg Injection used for?

Monovisc 88mg Injection is used for the treatment of dry eye syndrome (keratoconjunctivitis sicca). In addition to treating dryness, it is also helpful in protecting eyes. It is also used to treat dryness of cornea caused by trauma to it or when the eyes cannot be closed due to nerve paralysis.

Q. How do you use Monovisc 88mg Injection?

You should use Monovisc 88mg Injection exactly as directed by your doctor. Do not touch the tip of the container and avoid it coming in contact with eye or eyelid. After opening the eyelid, instil 1-2 drops in the eye with someone’s help. To prevent washout, try to avoid using any eye drop/eye ointment for 15 minutes at least.

Q. I wear contact lenses, can I use Monovisc 88mg Injection?

Yes, Monovisc 88mg Injection can be used with contact lenses. However, your doctor will tell you whether you can use eye drops while wearing the contact lenses or you need to take out contact lenses and then instil the drops.

Q. How often can you use Monovisc 88mg Injection?

It is recommended to use Monovisc 88mg Injection 4 times a day or you can use it more than 4 times if your doctor has advised you, based on your eye condition.

Q. How long do I need to use Monovisc 88mg Injection?

Continue using Monovisc 88mg Injection as long as your doctor has recommended. The time duration will depend on your eye condition. It can be used for an extended period of time, if required.

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Disclaimer:

Tata 1mg’s sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

1. Buys LM, Elliott ME. Osteoarthritis. In: DiPiro JT, Talbert RL, Yee GC, et al., editors. Pharmacotherapy: A Pathophysiologic Approach. 9th ed. New York, New York: McGraw-Hill Education; 2014. [Accessed 24 Jan. 2019] (online) Available from:

2. Sodium hyaluronate [Patient Information Leaflet]. [Accessed 27 Nov. 2019] (online) Available from:

3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 02 Apr. 2019] (online) Available from:

Manufacturer/Marketer address

Ground Floor Modi Tower, 98, Nehru Place, New Delhi, Delhi 110019

Country of origin: India
Expires on or after: April, 2025

A licensed vendor partner from your nearest location will deliver Monovisc 88mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor’s ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID:[email protected]
Address: 5th Floor Tower – B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Monovisc (High Molecular Weight Hyaluronan Injection) Side Effects, Warnings, Usage

Monovisk

• Generic Name: High Molecular Weight Hyaluronan Injection
• Brand Name: Monovisk

• Overview
• Professional Information
• Related Resources

Monovisc Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last viewed on RxList28 Feb 2018

Monovisc (High Molecular Weight Hyaluronan Injection) is a complex sugar used to treat osteoarthritis (OA) pain of the knee in patients who have failed to respond adequately to conservative non-drug therapy or simple analgesics tics (eg acetaminophen). Common side effects of Monovisc include:

• joint pain and swelling,
• injection site reaction,
• rash,
• Headache,
• dizziness,
• chills,
• urticaria
• pruritus,

9 0011 nausea,

• muscle cramps

,

• swelling of the legs and feet, and
• general malaise (malaise)

Monovisc is supplied in a 5 ml disposable syringe containing a 4 ml treatment dose. Monovisc may interact with other drugs. Tell your doctor about all medications and supplements you are taking. During pregnancy, Monovisk should only be used as directed. It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding.

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Our Monovisc (High Molecular Weight Hyaluronan Injectable) Side Effects Center provides a comprehensive overview of available drug information and potential side effects when taking this medication.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Consumer Information Monovisc

Get emergency medical help if you have signs of an allergic reaction : hives; labored breathing; swelling of the face, lips, tongue, or throat.

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Call your doctor right away if you have:

• bleeding;
• increased pain in knees; or
• signs of infection (warmth, swelling, redness) around the knee.

Common side effects may include:

• joint pain, stiffness or swelling;
• itching, numbness or tingling;
• headache, dizziness;
• back pain;
• swelling, pain, redness or slight discomfort at the injection site.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Monovisc (high molecular weight hyaluronan injection)

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Learn More ‘ Professional Information Monovisc

SIDE EFFECTS

Possible adverse health effects of the device

Device related adverse events reported

The most common adverse events associated with Monovisc are as follows: 90 003

• Arthralgia
• Edema joints
• Pain at injection site

Rash, headache, dizziness, chills, urticaria, pruritus, nausea, muscle spasms, peripheral edema and malaise have also been reported in association with intra-articular injections.

For a complete list of the frequency and frequency of adverse events identified in clinical studies, see the Safety section.

Read all FDA Prescribing Information for Monovisc (High Molecular Weight Hyaluronan Injection)

Read More ‘ Related Resources for Monovisc

Concomitant drugs

• Bextra
• Change
• Celebrex
• Dolobid
• Mobic

• Nal fon
• Synojoynt
• Voltaren
• Voltaren XR

Information for Monovisc patients is provided by Cerner Multum, Inc. , and Monovisc Consumer information is provided by First Databank, Inc., used under license and subject to their respective copyrights.

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instructions for use, dosage, composition, analogues, side effects / Pillintrip

901 65

Page reviewed by pharmacist Milityan Inessa Mesropovna Last update 2020-04-08

Attention!
The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

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Name of medication

The information provided in section Name of the medicinal product MONOVISC is based on data from another medicinal product with exactly the same composition as the medicinal product MONOVISC . Be
carefully and be sure to specify the information under section Name of the drug
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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MONOVISC

Composition of

The information provided in section Composition of MONOVISC is based on data from another medicine with exactly the same composition as medicine MONOVISC . Be
carefully and be sure to specify the information on section Composition
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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Sodium Hyaluronate

Therapeutic indications

The information provided in section Therapeutic indications of MONOVISC is based on data from another medicine with exactly the same composition as MONOVISC . Be
carefully and be sure to check the information under section Therapeutic indications
in the instructions for the medicine MONOVISC directly from the package or from the pharmacist in the pharmacy.

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Solution for intra-articular injection

Solution for intraocular administration

Solution for injection

osteoarthrosis and post-traumatic changes in the joints;

relief of pain and improvement of joint mobility;

as an aid in orthopedic surgery.

Eye surgery – in operations on the anterior and posterior segments of the eye to expand the anterior chamber of the eye, to separate tissues, to examine the retina during and after surgery, to perform laser therapy.

Eye surgery – for operations on the anterior and posterior segments of the eye to expand the anterior chamber of the eye, to separate tissues, to examine the retina during and after operations, to carry out laser therapy.

Dosage and Administration

The information provided in section Dosage and Administration of MONOVISC is based on data from another medicine with exactly the same composition as MONOVISC . Be
carefully and be sure to clarify the information in section Dosage and Administration
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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Solution for intra-articular injection

Solution for intraocular injection

Solution for injection

Intra-articular. In the knee and hip joints, the contents of one vial (20 mg/2 ml) or a filled syringe (20 mg/2 ml) should be administered once a week, in a course of 5 injections according to the standard method.

Method of administration

Before the administration of Hyalgan Phidias, the exudate from the joint capsule should be removed. The drug should be injected exactly into the joint cavity according to standard methods, taking into account the anatomical features. The same needle, once inserted before aspiration, can be used to remove the effusion and administer the drug. In this case, the syringe with the drug is attached to the needle freed from the syringe with the aspirated liquid. To confirm that the needle is in the joint cavity, an available amount of synovial fluid should be aspirated before the slow administration of the drug. You should follow the rules of asepsis and antisepsis during the procedure. The introduction of the drug into the joint cavity should be stopped if pain occurs during the injection. Avoid getting air into the syringe with the drug. Unused to the end of the drug is not subject to storage.

Intraocular. The dose depends on the characteristics of the surgical intervention. During operations on the anterior segment – the total volume (including repeated injections) usually does not exceed 1 ml; during operations on the posterior segment – 2-4 ml.

To minimize the risk of transient increases in intraocular pressure in the postoperative period, at the end of cataract surgery, it is recommended to remove Healon from the eye by irrigation/aspiration. Patients with glaucoma, as well as in cases where Healon is left in the eye for clinical reasons, should be prescribed prophylactically drugs that reduce intraocular pressure.

The administration of Healon is not complicated by its viscosity, since it decreases significantly when the drug passes through the cannula. Healon is easily removed from the anterior segment.

When preparing to inject, remove the syringe from the plastic bag. Before screwing the plastic tip to the piston and connecting the cannula, it is necessary to perforate its membrane by pressing the cartridge containing the solution towards the needle.

Intraocular. The dose depends on the characteristics of the surgical intervention. During operations on the anterior segment – the total volume (including repeated injections) usually does not exceed 1 ml; during operations on the posterior segment – 2-4 ml.

To minimize the risk of transient increases in intraocular pressure in the postoperative period, it is recommended that MONOVISC be removed from the eye by irrigation/aspiration at the end of cataract surgery. Patients with glaucoma, and also in cases where MONOVISC is left in the eye for clinical reasons, should be given prophylactic drugs that reduce intraocular pressure.

The administration of MONOVISC is not complicated by its viscosity, as it decreases significantly as the drug passes through the cannula. MONOVISC is easily removed from the anterior segment.

When preparing to inject, remove the syringe from the plastic bag. Before screwing the plastic tip to the piston and connecting the cannula, it is necessary to perforate its membrane by pressing the cartridge containing the solution towards the needle.

Contraindications

The information provided in section Contraindications MONOVISC is based on data from another medicine with exactly the same composition as MONOVISC . Be
carefully and be sure to check the information on section Contraindications
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

more…

No.

Side effects

The information provided in section Side effects of MONOVISC is based on data from another medicine with exactly the same composition as MONOVISC . Be
carefully and be sure to check the information in section Side effects
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

more…

Transient increase in intraocular pressure in the postoperative period with a maximum in 4-8 hours after surgery (due to mechanical blockade of the trabecular meshwork by the remnants of the solution). Allergic reactions.

Overdose

The information provided in section Overdose MONOVISC is based on data from another medicine with exactly the same composition as medicine MONOVISC . Be
carefully and be sure to specify the information on section Overdose
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

more…

No cases of overdose were noted.

Pharmacodynamics

The information provided in section Pharmacodynamics MONOVISC is based on data from another medicine with exactly the same composition as medicine MONOVISC . Be
carefully and be sure to specify the information on section Pharmacodynamics
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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Phidia Hyalgan is a sterile, pyrogen-free, viscous buffered aqueous solution of highly purified hyaluronic acid sodium salt fraction with a molecular weight of 500 to 730 kDa. Hyaluronic acid is an essential component of the extracellular matrix, present in high concentrations in articular cartilage and synovial fluid. Endogenous hyaluronic acid provides the viscosity and elasticity of the synovial fluid, and it is also necessary for the formation of proteoglycans in the articular cartilage. With osteoarthritis, there is a deficiency and qualitative changes in hyaluronic acid in the composition of synovial fluid and cartilage. Intra-articular injection of hyaluronic acid against the background of degenerative changes in the surface of the synovial cartilage and the pathology of the synovial fluid leads to an improvement in the functional state of the joint. When using Hyalgan Phidias, there is an improvement in the clinical course of osteoarthritis for six months from the moment of treatment, an anti-inflammatory and analgesic effect is observed.

Pharmacokinetics

The information provided in section Pharmacokinetics of MONOVISC is based on data from another medicine with exactly the same composition as the medicine MONOVISC . Be
carefully and be sure to specify the information on section Pharmacokinetics
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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The sodium salt of hyaluronic acid is eliminated from the synovial fluid within 2-3 days when injected intraarticularly. Pharmacokinetic studies have shown a rapid distribution of the substance in the synovial membrane. The highest concentrations of labeled hyaluronic acid were found in the synovial fluid and joint capsule, while lower concentrations were found in the synovial membrane, ligaments, and adjacent muscles.

Hyaluronic acid in the synovial fluid does not undergo significant metabolic changes. In experimental models, the main metabolism occurs in the periarticular tissues and the liver, excretion is mainly carried out by the kidneys.

Pharmacological group

The information provided in section Pharmacological group MONOVISC is based on data from another medicine with exactly the same composition as medicine MONOVISC . Be
carefully and be sure to specify the information on section Pharmacological group
in the instructions for the drug MONOVISC directly from the package or from the pharmacist in the pharmacy.

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• Diagnostic Reagent [Other Diagnostics]

Interactions

The information provided in Interactions MONOVISC same formulation as MONOVISC . Be
carefully and be sure to check the information on section Interaction
in the instructions for the medicine MONOVISC directly from the package or from the pharmacist in the pharmacy.