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Mrsa sinus infection symptoms. MRSA Sinus Infection: Symptoms, Treatment, and Prevention of Staph in Nose

What are the symptoms of a staph infection in the nose. How is MRSA sinus infection treated. Can nasal staph infections be prevented. What complications can arise from untreated nasal staph infections.

Understanding Staph Infections in the Nose

Staphylococcus aureus, commonly known as staph, is a bacteria that naturally resides on the skin and in the nasal passages of many individuals. While typically harmless, these bacteria can cause infections when they enter the body through breaks in the skin. Nasal staph infections occur when the bacteria infiltrate damaged tissue inside the nose.

Staph bacteria are highly contagious and can spread through various means:

  • Direct skin-to-skin contact
  • Sharing personal items like toothbrushes or razors
  • Respiratory droplets from coughing or sneezing (less common)

Causes of Nasal Staph Infections

Several factors can contribute to the development of a staph infection in the nose:

  • Excessive nose picking
  • Frequent and forceful nose blowing
  • Aggressive nose rubbing
  • Plucking or tweezing nasal hairs
  • Injuries or cuts inside the nose

These actions can create small wounds or irritations that allow staph bacteria to enter and colonize the tissue, leading to infection.

Recognizing Symptoms of Nasal Staph Infections

Identifying a staph infection in the nose early is crucial for prompt treatment. Common symptoms include:

  • Redness and swelling of the nose
  • Crusting around the nostrils
  • Boils inside one or both nostrils
  • Facial swelling
  • Pain in the affected area
  • Fever

Are all nasal staph infections symptomatic. Not necessarily. Some mild infections may resolve on their own without noticeable symptoms. However, if you experience persistent discomfort or any of the above signs, it’s important to seek medical attention.

Treatment Options for Nasal Staph Infections

The approach to treating staph infections in the nose varies depending on the severity of the infection. Here are some common treatment methods:

Home Remedies

For minor infections, simple home care may suffice:

  • Applying a clean, warm, damp cloth to affected areas to soothe sores and crusting
  • Practicing good hygiene to prevent spread of infection

Medical Interventions

More severe infections often require professional medical treatment:

  • Draining of pus-filled boils by a healthcare professional
  • Oral antibiotics to fight the infection systemically
  • Topical antimicrobial treatments applied directly to the affected area

Which is more effective for treating recurrent staph infections: oral antibiotics or topical treatments. Research suggests that topical antimicrobial medications may be more effective than oral antibiotics for preventing recurrent infections. This is partly due to the potentially lower resistance of S. aureus to topical treatments.

Preventing Nasal Staph Infections

While it’s not always possible to prevent staph infections, certain practices can reduce your risk:

  • Maintain good personal hygiene, especially hand washing
  • Avoid touching or picking your nose unnecessarily
  • Use tissues when blowing your nose and dispose of them immediately
  • Don’t share personal items like towels or razors
  • Keep cuts and scrapes clean and covered until healed

Can nasal decolonization help prevent staph infections. Yes, in some cases. Nasal decolonization involves using antimicrobial treatments to reduce the number of staph bacteria in the nose. This can be particularly helpful for individuals who experience recurrent infections or are at high risk due to medical conditions.

Potential Complications of Untreated Nasal Staph Infections

If left untreated, staph infections in the nose can lead to serious complications:

Facial Cellulitis

This bacterial infection affects the deeper layers of skin and can be life-threatening if not treated promptly. Symptoms include:

  • Tenderness and pain in the face
  • Skin redness and rash
  • Fever and chills
  • Loss of appetite

Cavernous Sinus Thrombosis (CST)

A rare but serious condition involving a blood clot in the cavernous sinuses. Symptoms of CST include:

  • Severe headache
  • Swelling around the eyes
  • Weakness of eye muscles, leading to drooping eyelids or double vision
  • Severe eye pain

Endocarditis

An infection of the inner lining of heart chambers and valves. Signs of endocarditis include:

  • Fever and chills
  • Fatigue and muscle aches
  • Difficulty breathing
  • Nausea and vomiting
  • Blood in urine

Pneumonia

Inflammation of the lungs due to infection. Common symptoms are:

  • Rapid or shallow breathing
  • Chest pain worsening with breathing or coughing
  • Rapid heartbeat
  • Fever and chills
  • Loss of appetite

Sepsis

A life-threatening condition where the body’s response to infection causes widespread inflammation. Sepsis requires immediate medical attention.

MRSA: A Serious Form of Staph Infection

Methicillin-resistant Staphylococcus aureus (MRSA) is a type of staph bacteria that has developed resistance to many common antibiotics. MRSA infections, including those in the nose, can be particularly challenging to treat.

Symptoms of MRSA Sinus Infection

MRSA sinus infections may present with similar symptoms to other staph infections, but they often progress more rapidly and are more severe. Additional symptoms may include:

  • Persistent and severe sinus pain
  • Thick, discolored nasal discharge
  • Reduced sense of smell
  • Headaches
  • Fatigue

Treatment for MRSA Sinus Infections

Treating MRSA sinus infections typically requires specialized antibiotics that are effective against resistant strains. These may include:

  • Vancomycin
  • Linezolid
  • Daptomycin
  • Ceftaroline

In some cases, a combination of antibiotics may be necessary. Treatment duration is often longer for MRSA infections compared to non-resistant staph infections.

When to Seek Medical Attention

While minor staph infections may resolve on their own, it’s crucial to recognize when professional medical care is needed. Seek immediate medical attention if you experience:

  • Persistent or worsening symptoms despite home care
  • Fever above 100.4°F (38°C)
  • Rapid spread of redness or swelling
  • Severe pain or tenderness
  • Signs of systemic infection (e.g., chills, body aches, fatigue)

Is it possible to distinguish between a regular staph infection and MRSA at home. No, it’s not possible to definitively diagnose MRSA without laboratory testing. If you suspect you have a staph infection, especially if it’s not responding to initial treatment, consult a healthcare provider for proper diagnosis and care.

Living with Recurrent Nasal Staph Infections

For some individuals, nasal staph infections can be a recurring problem. If you’re prone to these infections, consider the following strategies:

  • Work with your healthcare provider to develop a long-term management plan
  • Consider periodic nasal decolonization treatments
  • Be vigilant about hygiene, especially hand washing and avoiding nose touching
  • Boost your immune system through a healthy diet, regular exercise, and stress management
  • Consider using a humidifier to keep nasal passages moist and less prone to injury

Can probiotics help prevent recurrent staph infections. While research is ongoing, some studies suggest that certain probiotic strains may help reduce S. aureus colonization in the nose. However, more evidence is needed before probiotics can be recommended as a preventive measure for staph infections.

Emerging Research and Future Treatments

The field of staph infection treatment and prevention is continuously evolving. Some areas of current research include:

  • Development of new antibiotics effective against resistant strains
  • Exploration of bacteriophage therapy as an alternative to antibiotics
  • Investigation of nasal vaccines to prevent S. aureus colonization
  • Studies on the role of the microbiome in preventing staph infections

These advancements hold promise for more effective treatments and prevention strategies in the future, potentially reducing the burden of staph infections, including those in the nose.

Understanding the symptoms, causes, and treatment options for staph infections in the nose is crucial for early intervention and prevention of complications. By maintaining good hygiene practices and seeking prompt medical attention when necessary, you can effectively manage and reduce the risk of these infections. Remember, while some staph infections may be minor, others can lead to serious health issues if left untreated. Stay informed, be vigilant, and prioritize your nasal health to keep staph infections at bay.

Staph infection in nose: Symptoms, treatment, and diagnosis

A staphylococcus, or staph, infection is an infection caused by the bacteria Staphylococcus aureus.

Many people carry Staphylococcus aureus (S.aureus) on their skin or within their nose.

Here we look at the various causes and symptoms of a staph infection in the nose. We also outline the available treatment options for a nasal staph infection, as well as some tips for prevention.

Share on PinterestExcessively blowing or rubbing the nose is a possible cause of a staph infection in the nose.

The bacteria S. aureus cause staph infection.

Between 20–80% of humans carry S. aureus within their nasal passages. Most of the time, the bacteria do not cause any harm. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause an infection.

Damage to the surface of the skin may trigger a mild to a moderate staph infection. Damage to the deeper layers of the skin may trigger a severe or even life-threatening staph infection.

Staph bacteria are contagious and can spread to other people through:

  • skin-to-skin contact
  • sharing personal items, such as toothbrushes, razors, or washcloths
  • coughing or sneezing, although these types of transmission are less common

A staph infection in the nose can occur as a result of a scratch, sore, or other types of damage to the skin of the nose.

Some potential causes of a nasal staph infection include:

  • nose picking
  • excessively blowing or rubbing the nose
  • plucking or tweezing nasal hairs

A person who has a nasal staph infection may develop the following symptoms:

  • redness and swelling of the nose
  • crusting around the nostrils
  • boils inside one or both nostrils
  • facial swelling
  • pain
  • fever

In some cases, a staph infection may resolve by itself. In other cases, a person will require treatment to clear the infection and prevent further complications.

Some people may succeed in treating minor nasal infections at home. People can soothe sores and crusting by holding a clean, warm, damp cloth onto affected areas. It is important to wash the cloth afterward to avoid spreading the bacteria.

Some people may develop pus-filled boils inside the nostrils. A doctor will need to drain the boil in order to treat the infection and promote wound healing. This procedure typically involves the use of a local anesthetic.

If a nasal staph infection does not clear up by itself, a person may need to take oral antibiotics or apply topical antimicrobial treatments.

Without treatment, staph infections may recur. This is because S.aureus remains inside the nasal passages.

Prescription antibiotic treatments can reduce numbers of staph bacteria, thereby helping to prevent the staph infection from recurring.

Researchers have been investigating the best treatment to prevent recurrent staph infections. According to a 2015 review, topical antimicrobial medications may be more effective than oral antibiotics. This is because S. aureus may have a lower resistance to topical treatments.

Practicing good personal hygiene may also help to reduce the risk of repeat infections.

If a staph infection enters the bloodstream, it can cause serious complications. We list some potential complications below.

Facial cellulitis

Facial cellulitis is a bacterial infection affecting the deeper layers of the skin. Without treatment, the condition can be life-threatening.

Symptoms of facial cellulitis include:

  • tenderness and pain in the face
  • rash
  • skin redness
  • lockjaw
  • a fever
  • chills
  • loss of appetite

Cavernous sinus thrombosis

A cavernous sinus thrombosis (CST) is a blood clot that forms in the cavernous sinuses. This is the hollow space between the brain and the eye sockets.

A CST can develop when an infection in the face or skull spreads to the cavernous sinuses. Although rare, the condition can be life-threatening.

Symptoms of a CST include:

  • a fever
  • a severe headache
  • swelling around the eyes
  • a weakness of the eye muscles, resulting in drooping eyelids, or double vision
  • severe eye pain

Endocarditis

An infection can sometimes spread to the inner lining of the heart chambers and valves. The medical term for this is endocarditis.

Symptoms of endocarditis include:

  • a fever
  • chills
  • fatigue
  • aching muscles and joints
  • difficulty breathing
  • nausea and vomiting
  • blood in the urine

Pneumonia

Pneumonia is the medical term for inflammation of one or both lungs. It typically occurs as a result of infection.

In pneumonia, the tiny air sacs, or alveoli, within the lungs fill with fluid or pus. This makes it difficult for a person to breathe.

Some common symptoms of pneumonia include:

  • rapid or shallow breathing
  • breathlessness, even when resting
  • chest pain that worsens when breathing or coughing
  • rapid heartbeat
  • a fever
  • chills
  • feeling generally unwell
  • loss of appetite

Sepsis

Sepsis is a potentially life-threatening condition in which the body’s immune system overreacts to an infection. This overreaction leads to a toxic build-up of chemicals within the blood.

Symptoms of sepsis include:

  • rapid breathing
  • increased heart rate
  • a fever
  • chills
  • feeling confused or disorientated

Toxic shock syndrome

Toxic shock syndrome (TSS) is a rare condition in which staph bacteria release dangerous levels of toxins into the bloodstream. TSS can be life-threatening.

The symptoms of TSS come on suddenly and worsen rapidly. They include:

  • a fever
  • flu-like symptoms, such as a headache, body aches, and a sore throat
  • nausea and vomiting
  • diarrhea
  • a widespread skin rash that appears similar to sunburn
  • a bright red coloring of the lips, tongue, and eye-whites
  • difficulty breathing
  • fainting
  • confusion

There are steps a person can take to reduce their risk of developing or spreading a staph infection of the nose or skin. These include:

  • regularly washing hands with soap and clean water
  • showering or bathing daily to keep skin clean
  • covering any cuts or wounds with sterile bandaids or dressings
  • avoiding sharing personal items, such as toothbrushes, razors, and washcloths
  • covering the mouth and nose when coughing or sneezing
  • disposing of tissues after blowing the nose
  • avoiding picking the nose
  • using only sterile equipment to pluck or tweeze nasal hair, or avoiding these practices altogether

Some staph infections may resolve by themselves, while others may require treatment.

People should see a doctor if the staph infection:

  • is severe
  • lasts longer than a week, or keeps coming back
  • is getting worse, or spreading to other parts of the face
  • causes a skin rash or redness
  • causes fever or chills
  • causes breathing difficulty, or a change in heart rate

Anyone who has a weakened immune system should see a doctor at the first sign of a staph infection. This includes people who:

  • are elderly
  • have an autoimmune disease
  • are receiving chemotherapy
  • have received an organ transplant

Staph bacteria commonly live inside the nose and are usually harmless. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause infection.

A person who has a nasal staph infection may develop redness, sores, or crusting around the nostrils. A person may need antibiotics or topical antimicrobial medications to treat the infection.

People should seek treatment if their infection is severe or persistent or accompanied by other symptoms. People who have a weakened immune system should seek treatment as soon as possible to reduce the risk of complications.

Staph infection in nose: Symptoms, treatment, and diagnosis

A staphylococcus, or staph, infection is an infection caused by the bacteria Staphylococcus aureus.

Many people carry Staphylococcus aureus (S.aureus) on their skin or within their nose.

Here we look at the various causes and symptoms of a staph infection in the nose. We also outline the available treatment options for a nasal staph infection, as well as some tips for prevention.

Share on PinterestExcessively blowing or rubbing the nose is a possible cause of a staph infection in the nose.

The bacteria S. aureus cause staph infection.

Between 20–80% of humans carry S. aureus within their nasal passages. Most of the time, the bacteria do not cause any harm. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause an infection.

Damage to the surface of the skin may trigger a mild to a moderate staph infection. Damage to the deeper layers of the skin may trigger a severe or even life-threatening staph infection.

Staph bacteria are contagious and can spread to other people through:

  • skin-to-skin contact
  • sharing personal items, such as toothbrushes, razors, or washcloths
  • coughing or sneezing, although these types of transmission are less common

A staph infection in the nose can occur as a result of a scratch, sore, or other types of damage to the skin of the nose.

Some potential causes of a nasal staph infection include:

  • nose picking
  • excessively blowing or rubbing the nose
  • plucking or tweezing nasal hairs

A person who has a nasal staph infection may develop the following symptoms:

  • redness and swelling of the nose
  • crusting around the nostrils
  • boils inside one or both nostrils
  • facial swelling
  • pain
  • fever

In some cases, a staph infection may resolve by itself. In other cases, a person will require treatment to clear the infection and prevent further complications.

Some people may succeed in treating minor nasal infections at home. People can soothe sores and crusting by holding a clean, warm, damp cloth onto affected areas. It is important to wash the cloth afterward to avoid spreading the bacteria.

Some people may develop pus-filled boils inside the nostrils. A doctor will need to drain the boil in order to treat the infection and promote wound healing. This procedure typically involves the use of a local anesthetic.

If a nasal staph infection does not clear up by itself, a person may need to take oral antibiotics or apply topical antimicrobial treatments.

Without treatment, staph infections may recur. This is because S.aureus remains inside the nasal passages.

Prescription antibiotic treatments can reduce numbers of staph bacteria, thereby helping to prevent the staph infection from recurring.

Researchers have been investigating the best treatment to prevent recurrent staph infections. According to a 2015 review, topical antimicrobial medications may be more effective than oral antibiotics. This is because S. aureus may have a lower resistance to topical treatments.

Practicing good personal hygiene may also help to reduce the risk of repeat infections.

If a staph infection enters the bloodstream, it can cause serious complications. We list some potential complications below.

Facial cellulitis

Facial cellulitis is a bacterial infection affecting the deeper layers of the skin. Without treatment, the condition can be life-threatening.

Symptoms of facial cellulitis include:

  • tenderness and pain in the face
  • rash
  • skin redness
  • lockjaw
  • a fever
  • chills
  • loss of appetite

Cavernous sinus thrombosis

A cavernous sinus thrombosis (CST) is a blood clot that forms in the cavernous sinuses. This is the hollow space between the brain and the eye sockets.

A CST can develop when an infection in the face or skull spreads to the cavernous sinuses. Although rare, the condition can be life-threatening.

Symptoms of a CST include:

  • a fever
  • a severe headache
  • swelling around the eyes
  • a weakness of the eye muscles, resulting in drooping eyelids, or double vision
  • severe eye pain

Endocarditis

An infection can sometimes spread to the inner lining of the heart chambers and valves. The medical term for this is endocarditis.

Symptoms of endocarditis include:

  • a fever
  • chills
  • fatigue
  • aching muscles and joints
  • difficulty breathing
  • nausea and vomiting
  • blood in the urine

Pneumonia

Pneumonia is the medical term for inflammation of one or both lungs. It typically occurs as a result of infection.

In pneumonia, the tiny air sacs, or alveoli, within the lungs fill with fluid or pus. This makes it difficult for a person to breathe.

Some common symptoms of pneumonia include:

  • rapid or shallow breathing
  • breathlessness, even when resting
  • chest pain that worsens when breathing or coughing
  • rapid heartbeat
  • a fever
  • chills
  • feeling generally unwell
  • loss of appetite

Sepsis

Sepsis is a potentially life-threatening condition in which the body’s immune system overreacts to an infection. This overreaction leads to a toxic build-up of chemicals within the blood.

Symptoms of sepsis include:

  • rapid breathing
  • increased heart rate
  • a fever
  • chills
  • feeling confused or disorientated

Toxic shock syndrome

Toxic shock syndrome (TSS) is a rare condition in which staph bacteria release dangerous levels of toxins into the bloodstream. TSS can be life-threatening.

The symptoms of TSS come on suddenly and worsen rapidly. They include:

  • a fever
  • flu-like symptoms, such as a headache, body aches, and a sore throat
  • nausea and vomiting
  • diarrhea
  • a widespread skin rash that appears similar to sunburn
  • a bright red coloring of the lips, tongue, and eye-whites
  • difficulty breathing
  • fainting
  • confusion

There are steps a person can take to reduce their risk of developing or spreading a staph infection of the nose or skin. These include:

  • regularly washing hands with soap and clean water
  • showering or bathing daily to keep skin clean
  • covering any cuts or wounds with sterile bandaids or dressings
  • avoiding sharing personal items, such as toothbrushes, razors, and washcloths
  • covering the mouth and nose when coughing or sneezing
  • disposing of tissues after blowing the nose
  • avoiding picking the nose
  • using only sterile equipment to pluck or tweeze nasal hair, or avoiding these practices altogether

Some staph infections may resolve by themselves, while others may require treatment.

People should see a doctor if the staph infection:

  • is severe
  • lasts longer than a week, or keeps coming back
  • is getting worse, or spreading to other parts of the face
  • causes a skin rash or redness
  • causes fever or chills
  • causes breathing difficulty, or a change in heart rate

Anyone who has a weakened immune system should see a doctor at the first sign of a staph infection. This includes people who:

  • are elderly
  • have an autoimmune disease
  • are receiving chemotherapy
  • have received an organ transplant

Staph bacteria commonly live inside the nose and are usually harmless. However, if the skin of the nose becomes damaged, the bacteria can enter the wound and cause infection.

A person who has a nasal staph infection may develop redness, sores, or crusting around the nostrils. A person may need antibiotics or topical antimicrobial medications to treat the infection.

People should seek treatment if their infection is severe or persistent or accompanied by other symptoms. People who have a weakened immune system should seek treatment as soon as possible to reduce the risk of complications.

Methicillin-resistant Staphylococcus aureus (MRSA) facts

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What is MRSA?

MRSA is an acronym for Methicillin-resistant Staphylococcus aureus , a bacterium that is resistant to certain antibiotics. Most MRSA infections cause skin conditions.

What are the symptoms of the disease?

Staphylococcal skin infections usually begin as breaks in the skin, through which bacteria enter the skin and develop into an infection. The set of symptoms includes:

  • Local growth or irritation of the skin with characteristic redness, fever, swelling and pain. The affected area may be filled with pus or fluid.
  • In some cases, infected individuals may experience fever or chills.
  • Staphylococcal infections are often mistaken for bites from venomous arthropods.

How is the disease spread?

  • MRSA infection is spread by close contact with the skin of infected individuals or by sharing objects that have been in direct contact with affected skin. Examples of objects that can be shared to spread staph infections include: towels, soap, dressings, bandages, sheets, clothing, sauna benches or hot tubs, and exercise equipment.
  • Fluid or pus coming from the affected area is highly contagious.
  • Some people carry MRSA in the nose or throat without experiencing symptoms; at the same time, such persons are included in the high-risk group as the most susceptible to infection.

How is MRSA diagnosed and treated?

  • MRSA is usually diagnosed by swab analysis of the infected area. In the case of severe disease caused by MRSA infection, tests will help determine the antibiotic that will be effective in treating the infection.
  • Treatment may also involve draining the abscess and cleaning the wound with or without antibiotics.
  • Severe illness due to MRSA infection involves the use of antibiotics and, in some cases, hospitalization and surgery.

What are the ways to prevent MRSA?

  • Keep cuts and scrapes clean and covered/covered.
  • Avoid contact with wounds, bandages and dressings of others.
  • Consult your physician immediately if you notice reddening of the wound, an increase in its temperature, or a worsening of its condition after treatment.
  • Wash your hands regularly.
  • Avoid sharing personal hygiene items such as razors.
  • Shower after exercise and exercise.
  • Last Updated February 14, 2018
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Methicillin-resistant Staphylococcus aureus of zoonotic origin – a new threat to public health | Vaganova

1. Qin, Y. Antimicrobial Resistance and Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus Isolates from Child Patients of High-Risk Wards in Shenzhen, China / Y. Qin, F. Wen, Y. Zheng, R. Zhao, Q. Hu, R. Zhang // Jpn J Infect Dis. – 2017. – V. 70, N. 5. – P. 479-484.

2. Rolo, J. Evolutionary Origin of the Staphylococcal Cassette Chromosome mec (SCCmec) / J. Rolo, P. Worning, J.B. Nielsen, R. Bowden, O. Bouchami, P. Damborg, L. Guardabassi, V. Perreten, A. Tomasz, H. Westh, H. de Lencastre, M. Miragaia // Antimicrob Agents Chemother. – 2017. – V.61, N.6. – P. 2302-2316.

3. Wu, S. Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri / S. Wu, C. Piscitelli, H. de Lencastre, A. Tomasz // Microcrob Drug Resist. – 1996.-V.2, N.4. – P.435-41.

4. Aires-de-Sousa, M. Methicillin-resistant Staphylococcus aureus among animals: current overview / M. Aires-de-Sousa // Clin Microbiol Infect. – 2017. – V.23, N.6. – P. 373-380.

5. Sahibzada, S. Transmission of highly virulent community-associated MRSA ST93 and livestock-associated MRSA ST398 between humans and pigs in Australia / S. Sahibzada, S. Abraham, G.W. Coombs, S. Pang, M. Hernandez-Jover, D. Jordan, J. Heller // Sci Rep. – 2017. – V.7, N.1. – e. 5273.

6. Brandt, K.M. Evaluation of multiple-locus variable number of tandem repeats analysis for typing livestock-associated methicillin-resistant Staphylococcus aureus / K.M. Brandt, A. Mellmann, B. Ballhausen, C. Jenke, P.J. van der Wolf, E.M. Broens, K. Becker, R. Kock // PLoS One. – 2013. – V.8, N.1. – e54425.

7. Larsen, J. Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011 / J. Larsen, A. Petersen, M. Sorum, M. Stegger, L van Alphen, P. Valentiner-Branth, L.K. Knudsen, L.S. Larsen, B. Feingold, L.B. Price, P.S. Andersen, A.R. Larsen, R.L. Skov // Euro Surveill. – 2015. – V.20, N.37.

8. Kinross, P. Livestock-associated meticillin-resistant Staphylococcus aureus (MRSA) among human MRSA isolates, European Union/European Economic Area countries, 2013 / P. Kinross, A. Petersen, R. Skov, E. Van Hauwermeiren , A. Pantosti, F. Laurent, A. Voss A6, J. Kluytmans, M.J. Struelens, O. Heuer, D.L. Monnet // Euro Surveill. – 2017. – V.22, N.44.

9. Gostev, V. Molecular epidemiology and antibiotic resistance of methicillin-resistant Staphylococcus aureus circulating in the Russian Federation / V. Gostev, A. Kruglov, O. Kalinogo-rskaya, O. Dmitrenko, O. Khokhlova, T. Yamamoto , Y. Lobzin, I. Ryabchenko, S. Sidorenko // Infect Genet Evol. – 2017 – V. 53. – P.189-194.

10. Cuny, C. Livestock associated MRSA (LA-MRSA) and its relevance for humans in Germany / C. Cuny, R. Kck, W. Witte // Int J Med Microbiol. – 2013. – V.303, N.6-7. – P.331-337.

11. Larsen, J. Evidence for Human Adaptation and Food-borne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus / J. Larsen, M. Stegger, P. Andersen, A. Petersen, A.R. Larsen, H. Westh, Y. Agerso, A. Fetsch, B. Kraushaar, A. Kasbohrer, A.T. Fepler, S. Schwarz, C. Cuny, W. Witte, B. Butaye, O. Denis, M. Haenni, J.Y. Madec, E. Jouy, F. Laurent, A. Battisti, A. Franco, P. Alba, C. Mammina, A. Pantos-ti, M. Monaco, J.A. Wagenaar, E. de Boer, E. van Duijkeren, V. Heck M, L. Dominguez, C. Torres, M. Zarazaga, L.B. Price, R.L. Skov // Clin Infect Dis. – 2016. – V.63, N.10. – P.1349-1352.

12. Graveland, H. Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans / H. Graveland, B. Duim, E. van Duijkeren, D. Heederik, J.A. Wagenaar // Int J Med Microbiol. – 2011. – V.301, N.8. – P.630-634.

13. Neto, A.E.D. Emergence of methicillin-resistant Staphylococcus aureus from clonal complex 398 with no livestock association in Brazil / A.E.D. Neto, R.F.A. Pereira, R.E. Snyder, T.S. Machado, L.S.P. Andre, C.A.A. Cardoso, F. Aguiar-Alves // Mem Inst Oswaldo Cruz. – 2017. – V.112, N.9. – P.647-649.

14. Giacinti, G. Prevalence and characterization of methicil-lin-resistant Staphylococcus aureus carrying mecA or mecC and methicillin-susceptible Staphylococcus aureus in dairy sheep farms in central Italy / G. Giacinti, V. Carfora, A. Caprioli, D Sagrafoli, N. Marri, G. Giangolini, R. Amoruso, M. Iurescia, F. Stravino, S. Dottarelli, F. Feltrin, A. Franco, S. Amatiste, A. Battisti // J Dairy Sci. – 2017.- V.100, N.10. – P.7857-7863.

15. Locatelli, C. Short communication: Methicillin-resistant Staphylococcus aureus in bulk tank milk of dairy cows and effect of swine population density / C. Locatelli, P. Cremonesi, L. Bertocchi, M.G. Zanoni, A. Barberio, I. Drigo, G. Varisco, B. Castiglioni, V. Bronzo, P. Moroni // J Dairy Sci. – 2016.-V.99, N.3. – P.2151-2156.

16. Chen, C.J. Clinical and molecular features of MDR livestock-associated MRSA ST9 with staphylococcal cassette chromosome mecXII in humans / C.J. Chen, T.Y. Lauderdale, C.T. Lu, Y.Y. Chuang, C.C. Yang, T.S. Wu, C.Y. Lee, M.C. Lu, W.C. Ko, Y.C. Huang // J Antimicrob Chemother. – 2018. – V.73, N.1. – P.33-40.

17. Bi, Z. Identical genotypes of community-associated MRSA (ST59) and livestock-associated MRSA (ST9) in humans and pigs in rural China / Z. Bi, C. Sun C, S. Boijesson, B. Chen , X. Ji, B. Berglund, M. Wang, M. Nilsson, H. Yin, Q. Sun, A. Hulth, Y. Wang, C. Wu, Z. Bi, L.E. Nilsson // Zoonoses Public Health. – 2018. – V.65, N.3- P.367-371.

18. Yi, Y. Analysis of the Genetic Diversity in Methicillin-Resistant Staphylococcus aureus Isolates from Bovine Subclinical Mastitis Case in Xinjiang, China / Y. Yi, L. Su, B. Li, S. Li, B. Zhang, Y. Su // Foodborne Pathog Dis. – 2018. – V.15, N.9. – P.568-575.

19. Casey, J.A. Identifying livestock-associated methicil-lin-resistant Staphylococcus aureus in the United States–reply / J.A. Casey, B.S. Schwartz // JAMA Intern Med. – 2014. -V.174, N.5. – P.825.

20. Bosch, T. Livestock-associated MRSA: innocent or serious health threat? / T. Bosch, L.M. Schouls // Future Microbiol. – 2015. – V.10, N.4. – P.445-447.

21. Schulze-Geisthovel, S.V. Survey on the risk awareness of german pig and cattle farmers in relation to dealing with MRSA and antibiotics / S.V. Schulze-Geisthovel, E.V. Tappe, R.M. Schmithausen, J. Lepkojis, K. Rottgen, B. Petersen B2. // Infect Ecol Epidemiol. – 2016. -N.6. – P.29817.

22. Fischer, J. Simultaneous occurrence of MRSA and ES-BL-producing Enterobacteriaceae on pig farms and in nasal and stool samples from farmers / J. Fischer, K. Hille, I. Ruddat, A. Mellmann, R. Kock , L. Kreienbrock // Vet Microbiol. – 2017. – N.200. – P.107-113.

23. Liu, W. The prevalence and influencing factors of meth-icillin-resistant Staphylococcus aureus carriage in people in contact with livestock: A systematic review / W. Liu, Z. Liu, Z. Yao, Y. Fan, X Ye, S. Chen S. // Am J Infect Control. – 2015. -V.43, N.5. – P.469-475.

24. Ye, X. Genotypic and Phenotypic Markers of Livestock-Associated Methicillin-Resistant Staphylococcus aureus CC9 in Humans / X. Ye, X. Wang, Y. Fan, Y. Peng, L. Li, S. Li, J Huang, Z. Yao, S. Chen // Appl Environ Microbiol. – 2016. – V.82, N.13. -P.3892-3899.

25. Jayaweera, J.A.A. S. Antibiotic resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) isolated from livestock and associated farmers in Anuradhapura, Sri Lanka / J.A.A.S. Jayaweera, W.W. Kumbukgolla // Germs. -2017. – V.7, N.3. – P.132-139.

26. Leibler, J.H. Staphylococcus aureus Nasal Carriage among Beefpacking Workers in a Midwestern United States Slaughterhouse / J.H. Leibler, J.A. Jordan, K. Brownstein, L. Lander, L.B. Price, M.J. Perry // PLoS One. – 2016. – V.11, N.2. – e0148789.

27. Antoci, E. Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among subjects working on bovine dairy farms / E. Antoci, M.R. Pinzone, G. Nunnari, S. Stefani, B. Cacopardo // Infez Med. -2013. – V.21, N.2. – P.125-129.

28. Bal, A.M. Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated methicillin-resistant Staphylococcus aureus: Blurring of the traditional definitions / A. M. Bal, G.W. Coombs, M.T.G. Holden, J.A. Lindsay, G.R. Nimmo, P. Tattevin, R.L. Skov // J Glob Antimicrob Resist. – 2016. – N.6. – P.95-101.

29. Anker, J.C.H. Distance to pig farms as a risk factor for community-onset livestock-associated MRSA CC398 infection in persons without known contact to pig farms-A nationwide study / J.C.N. Anker, A. Koch, S. Ethelberg, K. Mlbak, J. Larsen, M.R. Jepsen // Zoonoses Public Health. – 2018. – V.65, N. 3. – P.352-360.

30. Bosch, T. Next-Generation Sequencing Confirms Presumed Nosocomial Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in the Netherlands / T. Bosch, S. Witteveen, A. Haenen, F. Landman, L.M. Schouls // Appl Environ Microbiol. – 2016. – V.82, N.14. – P.40814089.

31. Hatcher, S.M. Occurrence of methicillin-resistant Staphylococcus aureus in surface waters near industrial hog operation spray fields / S.M. Hatcher, K.W. Myers, C.D. Heaney, J. Larsen, D. Hall, M.B. Miller, J.R. Stewart // Sci Total Environ. – 2016. – N.565. – P.1028-1036.

32. Kock, R. Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) as causes of human infection and colonization in Germany / R. Kock, F. Schaumburg, A. Mellmann, M. Koksal, A. Jurke, K Becker, A.W. Friedrich // PLoS One. – 2013. – V.8, N.2. – e55040.

33. Larsen, J. Emergence of Livestock-Associated Methicil-lin-Resistant Staphylococcus aureus Bloodstream Infections in Denmark / J. Larsen, A. Petersen, A.R. Larsen, R.N. Sieber, M. Stegger, A. Koch, F.M. Aarestrup, L.B. Price, R.L. Skov // Clin Infect Dis. – 2017. – V.65, N.7. – P.1072-1076.

34. Manara, S. Whole-genome epidemiology, characterization, and phylogenetic reconstruction of Staphylococcus aureus strains in a paediatric hospital / S. Manara, E. Pasolli, D. Dolce, N. Ravenni, S. Campana, F. Armanini , F. Asnicar, A. Mengoni, L. Galli, C. Montagnani, E. Venturini, O. Rota-Stabelli, G. Grandi, G. Taccetti, N. Segata // Genome Med. -2018. -V.10, N.1. – P. 82.

35. Dodemont, M. Emergence of livestock-associated MRSA isolated from cystic fibrosis patients: Result of a Belgian national survey / M. Dodemont, M.A. Argudin, J. Willekens, E. Vanderhelst, D. Pierard, V.Y. Miendje Deyi, L. Hanssens, H. Franckx, P. Schelstraete, I. Leroux-Roels, C. Nonhoff, A. Deplano, C. Knoop, A. Malfroot, O. Denis // J Cyst Fibres. – 2018. – pii: S1569-1993(18)30577-0.

36. Ballhausen, B. LA-MRSA CC398 differ from classical community acquired-MRSA and hospital acquired-MRSA lineages: functional analysis of infection and colonization processes / B. Ballhausen, P. Jung, A. Kriegeskorte, P.E. Makgotlho, U. Ruffing, L. von Muller, R. Kock, G. Peters, M. Herrmann, W. Ziebuhr, K. Becker, M. Bischoff // Int J Med Microbiol. – 2014. – V.304, N.7. – P.777-786.

37. Mutters, N.T. Comparison of livestock-associated and health care-associated MRSA-genes, virulence, and resistance / N.T. Mutters, C.P. Bieber, C. Hauck, G. Reiner, V. Malek, U. Frank // Diagn Microbiol Infect Dis. – 2016. – V.86, N.4. — P.417 — 421.

38. Stevens, M.J.A. Draft Genome Sequence of Staphylococcus aureus S681, a Tetracycline-Sensitive Livestock-Associated Methicillin-Resistant Clonal Complex 398 Strain / M.J.A. Stevens, R. Stephan, S. Johler // Genome Announcement. – 2017. – V. 5, N.33. — e.00805-00817.

39. Larsen, J. Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline / J. Larsen, J. Clasen, J.E. Hansen, W. Paulander, A. Petersen, A.R. Larsen, D. Frees // Antimicrob Agents Chemother. – 2016. – V.60, N.7. – P.4401-4403.

40. Yan, X. Genetic features of livestock-associated Staphylococcus aureus ST9 isolates from Chinese pigs that carry the lsa(E) gene for quinupristin/dalfopristin resistanc / X. Yan, Z. Li, M.A. Chlebowicz, X. Tao, M. Ni, Y. Hu, Z. Li, H. Grundmann, S. Murray, B. Pascoe, S.K. Sheppard, X. Bo, J.M. Dijl, P. Du, M. Zhang, Y. You, X. Yu, F. Meng, S. Wang, J. Zhang // Int J Med Microbiol. – 2016. – V.306, N.8. — P.722-729.

41. Hau, S.J. Antimicrobial Resistance Distribution Differs Among Methicillin Resistant Staphylococcus aureus Sequence Type (ST) 5 Isolates From Health Care and Agricultural Sources / Hau S.J., J.S. Haan, P.R. Davies, T. Frana, T.L. Nicholson // Front Microbiol. – 2018. – V.9, N.2102.

42. Sieber, R.N. Drivers and Dynamics of Methicillin-Resistant Livestock-Associated Staphylococcus aureus CC398 in Pigs and Humans in Denmark / R.N. Sieber, R.L. Skov, J. Nielsen, J. Schulz, L.B. Price, F.M. Aarestrup, A.R. Larsen, M. Stegger, J. Larsen // MBio. — 2018. — V.9, N.6. — e02142-18.

43. Garcia-Graells, C. Livestock veterinarians at high risk of acquiring methicillin-resistant Staphylococcus aureus ST398 / C. Garcia-Graells, J. Antoine, J. Larsen, B. Catry, R. Skov, O. Denis / / Epidemiol Infect. – 2012. – V.140, N.3. – P.383-389.

44. Luini, M. Methicillin-resistant Staphylococcus aureus (MRSA) is associated with low within-herd prevalence of intramammary infections in dairy cows: Genotyping of isolates / M. Luini, P. Cremonesi, G. Magro, V. Bianchini , G. Minozzi, B. Castiglioni, R. Piccinini // Vet Microbiol. – 2015. – V.178, N. 3-4. – P.270-274.

45. Kraushaar, B. Acquisition of virulence factors in livestock-associated MRSA: Lysogenic conversion of CC398 strains by virulence gene-containing phages / B. Kraushaar, J.A. Hammerl, M. Kienol, M.L. Heinig, N. Sperling, M. Dinh Thanh, J. Reetz, C. Jackel, A. Fetsch, S. Hertwig // Sci Rep. – 2017. – V.7, V.1. — P.2004.

46. Fitzgerald, J.R. Human origin for livestock-associated methicillin-resistant Staphylococcus aureus / J.R. Fitzgerald // MBio. – 2012. – V.3, N.2. — e.00082-12.

47. Harrison, E.M. Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC / E.M. Harrison, G.K. Paterson, M.T. Holden, J. Larsen, M. Stegger, A.R. Larsen, A. Petersen, R.L. Skov, J.M. Christensen, A. Bak Zeuthen, O. Heltberg, S.R. Harris, R.N. Zadoks, J. Parkhill, S.J. Peacock, M.A. Holmes // EMBO Mol Med. – 2013. – V.5, N.4. – P.509-515.

48. Perez-Moreno, M.O., Unusual presence of the immune evasion gene cluster in livestock-associated MRSA of lineage CC398 causing peridural and psoas abscesses in a poultry farmer / M.O. Perez-Moreno, M.J. Centelles-Serrano, J. Nogales-Lopez, M.F. Domenech-Spanedda, C. Lozano, C. Torres // En-ferm Infecc Microbiol Clin. — 2017 Dec;35(10):651-654.

49. Gonjalves da Silva, A. A phylogenomic framework for assessing the global emergence and evolution of clonal complex 398 methicillin-resistant Staphylococcus aureus / A. Gonjalves da Silva, S.L. Baines, G.P. Carter, H. Heffernan, N.P. French, X. Ren, T. Seemann, D. Bulach, J. Kwong, T.P. Stinear, B.P. Howden, D.A. Williamson // Microb Genom. – 2017. – V.3, N.1. — e000105.

50. van Alen, S. In the center of an epidemic: Fifteen years of LA-MRSA CC398 at the University Hospital Munster / S. van Alen, B. Ballhausen, G. Peters, A.W. Friedrich, A. Mellmann, R. Kock, K. Becker // Vet Microbiol. – 2017. – N.200. – P.19-24.

51. Kock, R. Characteristics of hospital patients colonized with livestock-associated meticillin-resistant Staphylococcus aureus (MRSA) CC398 versus other MRSA clones / R. Kock, K. Siam, S. Al-Malat, J. Christmann, F Schaumburg, K. Becker, A.W. Friedrich // J Hosp Infect. — 2011. — V.79, N.4. – P.292-296.

52. Reynaga, E. Clinical impact and prevalence of MRSA CC398 and differences between MRSA-TetR and MRSA-TetS in an area of ​​Spain with a high density of pig farming: a prospective cohort study / E. Reynaga, C. Torres , M. Garcia-Nunez, M. Navarro, A. Vilamala, E. Puigoriol, G.E. Lucchetti, M. Sabria // Clin Microbiol Infect. – 2017. – V.23, N.9. — P.678.

53. Hetem, D.J. Transmissibility of livestock-associated methicillin-resistant Staphylococcus aureus / D.J. Hetem, M.C. Bootsma, A. Troelstra, M.J. Bonten // Emerg Infect Dis. — 2013. — V.19, N.11. — P.1797-1802.

54. Li, J. Characterization of pig-associated methicillin-resistant Staphylococcus aureus / J. Li, N. Jiang, Y. Ke, A.T. FeBler, Y. Wang, S. Schwarz, C. Wu // Vet Microbiol. – 2017. – N.201. – P.183-187.

55. Sorensen, A.I.V. Risk factors for the occurrence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in Danish pig herds / A.I.V. Sorensen, V.F. Jensen, A. Boklund, T. Halasa, H. Christensen, N. Toft // Prev Vet Med. — 2018. — N.159. — P.22-29.

56. Bos, M.E. Livestock-associated MRSA prevalence in veal calf production is associated with farm hygiene, use of antimicrobials, and age of the calves / M.E. Bos, H. Graveland, L. Portengen, J.A. Wagenaar, D.J. Heederik // Prev Vet Med. – 2012. – V.105, N.1-2. – P.155-159.

57. Agabou, A. Emergence of Nasal Carriage of ST80 and ST152 PVL+ Staphylococcus aureus Isolates from Livestock in Algeria / A. Agabou, Z. Ouchenane, C. Ngba Essebe, S. Khemissi, M.