How do nabumetone and ibuprofen differ in their uses and effectiveness. What are the key considerations when choosing between these NSAIDs for pain management. How do the side effects and costs of nabumetone compare to ibuprofen.

Understanding Nabumetone and Ibuprofen: Key Differences and Similarities

Nabumetone and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs) widely used for pain management and inflammation reduction. While they share some similarities, there are notable differences in their applications, availability, and effects.

What sets nabumetone apart from ibuprofen? Nabumetone is a prescription-only medication, primarily used to treat pain associated with osteoarthritis and rheumatoid arthritis. It’s available in 500 mg and 750 mg tablets, with a typical daily dosage of up to 2000 mg, taken once or twice daily.

How does ibuprofen differ? Ibuprofen, known by brand names like Advil and Motrin, is available both over-the-counter and as a prescription. It has a broader range of applications, including fever reduction, menstrual pain relief, and treatment of headaches and backaches. Ibuprofen is usually taken every six to eight hours, depending on the formulation and strength.

Conditions Treated: Comparing the Therapeutic Uses of Nabumetone and Ibuprofen

Both nabumetone and ibuprofen are FDA-approved for treating mild to moderate pain and inflammation associated with osteoarthritis and rheumatoid arthritis. However, their uses extend beyond these primary indications.

• Osteoarthritis: Both drugs effectively manage pain from cartilage breakdown around joints.
• Rheumatoid arthritis: Nabumetone and ibuprofen help alleviate pain caused by the immune system attacking joints.
• General pain relief: As NSAIDs, both medications can treat various types of mild to moderate pain.

Are there any unique applications for each drug? Ibuprofen is FDA-approved for treating fever and menstrual cramps, while nabumetone may be used off-label for these conditions. Additionally, both drugs can be effective for headaches, musculoskeletal pain, and lower back pain.

Efficacy Comparison: Nabumetone vs Ibuprofen in Clinical Settings

When it comes to effectiveness, both nabumetone and ibuprofen have proven their worth in clinical settings. However, their efficacy can vary depending on the specific condition and individual patient response.

How do these drugs compare in clinical trials? A randomized, controlled clinical trial involving around 4,000 patients with osteoarthritis or rheumatoid arthritis compared nabumetone to other NSAIDs, including ibuprofen. After 12 weeks of treatment, researchers found that nabumetone was similar in effectiveness to ibuprofen and other NSAIDs for osteoarthritis. Interestingly, nabumetone showed superior efficacy in treating rheumatoid arthritis compared to other NSAIDs.

Does the onset of action differ between the two drugs? Yes, there’s a notable difference in how quickly these medications take effect. Nabumetone generally has a slower onset, taking about one week to start working and up to two weeks for complete symptom relief. In contrast, ibuprofen begins to work within 30 minutes to an hour, although it may require multiple daily doses for sustained relief.

Cost and Coverage: Analyzing the Financial Aspects of Nabumetone and Ibuprofen

The cost and insurance coverage of nabumetone and ibuprofen can significantly impact a patient’s choice between these medications. Understanding the financial aspects can help in making an informed decision.

How does insurance coverage compare for these drugs? Most Medicare and insurance plans cover generic nabumetone. The copay can range from $0 to $57, depending on the specific plan. For ibuprofen, over-the-counter versions are typically not covered by insurance. However, prescription-strength ibuprofen is generally covered by most Medicare and insurance plans.

What are the out-of-pocket costs for these medications? Without insurance, the average cash price for nabumetone is around $79.99. However, using a SingleCare nabumetone coupon can reduce the cost to about $19. For ibuprofen, the average retail price is approximately $50 for 30 prescription-strength tablets. Discount programs and coupons can help lower these costs for both medications.

Side Effects and Safety: Comparing the Risk Profiles of Nabumetone and Ibuprofen

As with all medications, nabumetone and ibuprofen come with potential side effects. Understanding these risks is crucial for patients and healthcare providers when choosing between these NSAIDs.

What are the most common side effects of these drugs? Both medications primarily cause gastrointestinal side effects, including indigestion, diarrhea, and constipation. However, nabumetone may have a higher likelihood of causing indigestion, abdominal pain, and diarrhea compared to ibuprofen.

• Nausea
• Dizziness
• Headache
• Rash
• Fluid retention

Are there any serious side effects to be aware of? Both nabumetone and ibuprofen can potentially cause serious adverse effects, particularly with long-term use or in high doses. These may include:

• Increased risk of heart attack or stroke
• Gastrointestinal bleeding or ulceration
• Kidney problems
• Liver dysfunction
• Allergic reactions

How does the safety profile of nabumetone compare to ibuprofen? Some studies suggest that nabumetone may have a slightly better gastrointestinal safety profile compared to traditional NSAIDs like ibuprofen. However, this advantage is not definitively established, and both drugs require careful consideration of risks and benefits.

Drug Interactions: Understanding Potential Complications with Nabumetone and Ibuprofen

Both nabumetone and ibuprofen can interact with other medications, potentially leading to adverse effects or reduced efficacy. Being aware of these interactions is crucial for safe and effective treatment.

What are some common drug interactions to be cautious of? Both medications can interact with:

• Blood thinners (e.g., warfarin)
• Antihypertensive medications
• Diuretics
• Selective serotonin reuptake inhibitors (SSRIs)
• Other NSAIDs

Are there any unique interactions for either drug? Nabumetone may have fewer interactions with lithium compared to ibuprofen. However, both drugs can potentially increase lithium levels, requiring careful monitoring.

How can patients minimize the risk of drug interactions? It’s essential to inform healthcare providers about all medications, supplements, and herbal products being used. Regular monitoring and potential dose adjustments may be necessary when combining these NSAIDs with other drugs.

Special Considerations: Nabumetone and Ibuprofen in Specific Patient Populations

Certain patient groups may require special consideration when using nabumetone or ibuprofen. Understanding these specific situations can help guide appropriate usage and minimize risks.

How do these drugs affect older adults? Both nabumetone and ibuprofen should be used with caution in older adults due to an increased risk of gastrointestinal bleeding and kidney problems. Lower doses and shorter durations of use may be recommended.

What about pregnant and breastfeeding women? NSAIDs, including nabumetone and ibuprofen, are generally not recommended during pregnancy, especially in the third trimester. They may also pass into breast milk, so caution is advised for nursing mothers.

Are there considerations for patients with pre-existing conditions? Individuals with a history of gastrointestinal ulcers, bleeding disorders, heart disease, or kidney problems should use these medications under close medical supervision. In some cases, alternative pain management strategies may be more appropriate.

Cardiovascular Risk Assessment

How do nabumetone and ibuprofen affect cardiovascular health? Both drugs carry a potential risk of cardiovascular events, particularly with long-term use or high doses. Patients with pre-existing heart conditions or risk factors should discuss these risks with their healthcare provider.

Is there a difference in cardiovascular risk between the two drugs? Some studies suggest that nabumetone may have a slightly lower cardiovascular risk compared to traditional NSAIDs like ibuprofen. However, this difference is not conclusively established, and individual risk factors should be considered.

Renal Function Considerations

How do these NSAIDs impact kidney function? Both nabumetone and ibuprofen can affect kidney function, particularly in patients with pre-existing renal impairment or those at risk of kidney problems. Regular monitoring of kidney function may be necessary for long-term users.

Are there any renal-specific differences between nabumetone and ibuprofen? While both drugs can impact renal function, some studies suggest that nabumetone may have a slightly more favorable renal profile. However, this advantage is not definitively established, and caution is still warranted in at-risk patients.

Choosing Between Nabumetone and Ibuprofen: Factors to Consider

Selecting the most appropriate NSAID depends on various factors, including the specific condition being treated, individual patient characteristics, and potential risks and benefits.

What should patients and healthcare providers consider when choosing between nabumetone and ibuprofen?

1. Specific condition and symptoms
2. Desired onset of action
3. Frequency of dosing
4. Individual risk factors (e.g., gastrointestinal, cardiovascular, renal)
5. Cost and insurance coverage
6. Potential drug interactions
7. Patient preference and lifestyle considerations

How can patients make an informed decision? Discussing these factors with a healthcare provider is crucial. They can provide personalized recommendations based on the patient’s medical history, current medications, and specific needs.

Alternative Pain Management Strategies

Are there non-NSAID alternatives for pain management? In some cases, alternative approaches may be recommended, especially for patients at high risk of NSAID-related complications. These may include:

• Acetaminophen (paracetamol)
• Topical pain relievers
• Physical therapy
• Acupuncture
• Cognitive behavioral therapy
• Lifestyle modifications (e.g., exercise, weight management)

How can these alternatives be incorporated into a pain management plan? A comprehensive approach to pain management often involves a combination of pharmacological and non-pharmacological strategies. Working closely with healthcare providers can help develop an individualized plan that maximizes benefits while minimizing risks.

In conclusion, both nabumetone and ibuprofen offer effective pain relief for various conditions, particularly arthritis-related pain. While they share many similarities as NSAIDs, their differences in availability, onset of action, and potential side effect profiles make them suitable for different patient needs. The choice between these medications should be made in consultation with a healthcare provider, taking into account individual factors such as the specific condition being treated, patient characteristics, and potential risks and benefits. Regular monitoring and open communication with healthcare providers are essential for safe and effective use of these medications.

Differences, similarities, and which is better for you

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ

Nabumetone and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation from arthritis. Both nabumetone and ibuprofen are generic medications that work by blocking the release of prostaglandins, which are substances partly responsible for inflammation and pain in the body.

Ibuprofen may be a more familiar household name than nabumetone. However, both NSAIDs are effective for relieving pain and stiffness in the joints for those with osteoarthritis and rheumatoid arthritis. Continue reading to learn about other important differences between these drugs.

What are the main differences between nabumetone and ibuprofen?

Nabumetone is the generic name for the now discontinued, Relafen. It is available with a prescription from a doctor and primarily used to treat pain from osteoarthritis and rheumatoid arthritis. Generic nabumetone tablets are available in strengths of 500 mg and 750 mg. The typical dosage of nabumetone is up to 2000 mg per day taken as a once-daily or twice-daily dose.

Ibuprofen is known by popular brand names like Advil and Motrin. Unlike nabumetone, ibuprofen is available as a prescription or over-the-counter (OTC) pain reliever. While ibuprofen can treat pain from arthritis, it is also labeled to treat fever, menstrual pain, and pain from headaches or backaches. Ibuprofen is usually taken every six to eight hours depending on the strength and formulation.

Conditions treated by nabumetone and ibuprofen

Nabumetone and ibuprofen are both FDA approved to treat mild to moderate pain and inflammation from osteoarthritis and rheumatoid arthritis. Osteoarthritis and rheumatoid arthritis are chronic conditions that affect the joints; however, osteoarthritis is characterized by the breakdown of cartilage around the joints over time whereas rheumatoid arthritis develops when the immune system attacks the joints.

As NSAIDs, nabumetone and ibuprofen can also treat mild to moderate pain. More specifically, NSAIDs can treat headaches, musculoskeletal pain around the neck, and lower back pain. While ibuprofen is FDA approved to treat pain, fever, and menstrual cramps (primary dysmenorrhea), nabumetone may be used as an off-label treatment.

Is nabumetone or ibuprofen more effective?

Nabumetone and ibuprofen are effective NSAID pain relievers when used as prescribed. Both drugs have been FDA approved to treat pain and inflammation from arthritis. The more effective NSAID is the one that works best for your specific condition and symptoms.

In a randomized, controlled clinical trial, nabumetone was compared to other NSAIDs like ibuprofen, naproxen, and diclofenac in around 4,000 patients with osteoarthritis or rheumatoid arthritis. After 12 weeks of treatment, researchers found that nabumetone was similar in effectiveness to ibuprofen and other NSAIDs when treating osteoarthritis. However, the study found that nabumetone was more effective than the other NSAIDs for rheumatoid arthritis.

Nabumetone generally takes longer to work than ibuprofen and other NSAIDs. It usually takes around one week for nabumetone to start working and up to two weeks for complete symptom relief. On the other hand, ibuprofen starts working within 30 minutes to an hour, although it may need to be taken several times per day for complete relief.

Consult your healthcare provider for medical advice on the best pain reliever for you. Your healthcare provider may prescribe over-the-counter or prescription drugs to help treat your pain.

Coverage and cost comparison of nabumetone vs. ibuprofen

Most Medicare and insurance plans will cover generic nabumetone. The copay for nabumetone will depend on the insurance plan but can range from $0 to $57. Without insurance, the average cash price of nabumetone is around $79.99. With a SingleCare nabumetone coupon, you save on the drug price and pay around $19.

Most insurance plans will not cover the over-the-counter version of ibuprofen. However, with a prescription, most Medicare and insurance plans will cover ibuprofen. The average retail price of ibuprofen is around $50 for 30 prescription-strength tablets. Using a SingleCare ibuprofen coupon card (prescription required) may help lower the cost of ibuprofen.

Common side effects of nabumetone vs. ibuprofen

Nabumetone and ibuprofen can cause similar side effects. The most common side effects of these NSAIDs are gastrointestinal side effects, like indigestion, diarrhea, and constipation. Compared to ibuprofen, nabumetone may have a higher chance of causing indigestion, abdominal pain, and diarrhea.

Other possible side effects of nabumetone and ibuprofen include nausea, dizziness, swelling in the hands or feet (edema), headache, rash, and tinnitus.

Serious side effects of nabumetone and ibuprofen may include high blood pressure, kidney problems, heart attack, stroke, and stomach or intestinal ulcers. Allergic reactions are also possible. Seek immediate medical attention if you experience serious side effects or side effects that persist or worsen.

Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.
Source: DailyMed (Nabumetone), DailyMed (Ibuprofen)

Drug interactions of nabumetone vs. ibuprofen

NSAIDs should be used with caution with drugs like warfarin and aspirin. Taking anticoagulants or antiplatelet drugs with NSAIDs can increase the risk of gastrointestinal bleeding and ulcers.

NSAIDs have the potential to increase blood pressure. Therefore, the effects of blood pressure lowering medications, such as lisinopril and losartan, may be reduced if NSAIDs and blood pressure medications are taken together.

Nabumetone and ibuprofen can decrease the effects of diuretic medications. Kidney function may need to be monitored while taking NSAIDs and diuretics together.

Taking nabumetone or ibuprofen with lithium or methotrexate can lead to accumulated levels of lithium or methotrexate in the body. This could lead to lithium or methotrexate toxicity.

This is not a complete list of possible drug interactions.

Consult a healthcare professional for other possible drug interactions.

Warnings of nabumetone and ibuprofen

Nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of cardiovascular events, such as heart attack and stroke. Those with heart disease or risk factors for heart disease, such as high blood pressure or high cholesterol, should avoid NSAIDs or use them with caution.

Medications like nabumetone and ibuprofen can also increase the risk of gastrointestinal events, including ulcers and intestinal bleeding. Elderly patients and those with a history of gastric ulcers should avoid NSAIDs or use them with caution. The incidence of gastrointestinal bleeding may be slightly lower with nabumetone than with ibuprofen.

NSAIDs may cause fluid retention, or edema, and worsening of heart failure. Caution should be advised in patients with a history of heart failure.

Long-term use of NSAIDs may cause damage to the kidneys over time. Consult your healthcare provider if you have a history of kidney problems before using NSAIDs. Talk to your doctor about other possible side effects or adverse events before using NSAIDs, such as nabumetone or ibuprofen.

Frequently asked questions about nabumetone vs. ibuprofen

What is nabumetone?

Nabumetone is a generic NSAID analgesic, or pain reliever. It is the generic name for Relafen, and can only be obtained with a prescription. Nabumetone is usually taken once or twice daily as an oral tablet to treat osteoarthritis and rheumatoid arthritis.

What is ibuprofen?

Ibuprofen works as an NSAID to relieve pain and inflammation caused by osteoarthritis or rheumatoid arthritis. Although it is available as an over-the-counter medication to treat pain and fever, it can also be prescribed in higher strengths to treat more severe pain. Ibuprofen comes as an oral tablet, liquid solution, capsule, and injection. Brand names of ibuprofen include Advil and Motrin.

Are nabumetone and ibuprofen the same?

Nabumetone and ibuprofen are not the same. Although they are both NSAID pain relievers, nabumetone and ibuprofen are dosed differently and may have slightly different effects. Nabumetone, which requires a prescription, can be taken once daily while ibuprofen, which is available over the counter, is usually taken multiple times throughout the day. Both nabumetone and ibuprofen can treat chronic pain from arthritis.

Is nabumetone or ibuprofen better?

Compared to placebo, or no treatment at all, nabumetone and ibuprofen are both effective for treating pain and inflammation from arthritis. Nabumetone may be preferred for its once- or twice-daily dosing. However, nabumetone may have the potential to cause more indigestion than ibuprofen, and it is only available with a prescription. The better NSAID is the most cost-effective treatment for you as determined with the help of your doctor.

Can I use nabumetone or ibuprofen while pregnant?

Nabumetone and ibuprofen, like other NSAIDs, should be avoided during late pregnancy. Taking NSAIDs during late pregnancy may increase the risk of birth defects and miscarriage. Consult your healthcare provider if you are breastfeeding before taking NSAIDs.

Can I use nabumetone or ibuprofen with alcohol?

Drinking alcohol in moderation while taking nabumetone or ibuprofen as prescribed is generally safe. Problems may start when long-term NSAID use is combined with excessive consumption of alcohol. Regularly drinking alcohol with NSAIDs may lead to an increased risk of stomach ulcers, kidney impairment, and other adverse side effects.

How long does it take for nabumetone to work?

It can take one week to start feeling the effects of nabumetone. In some cases, it can take two weeks or longer to feel maximum relief with nabumetone.

Is nabumetone like tramadol?

Nabumetone is a nonsteroidal anti-inflammatory drug while tramadol is an opioid. Tramadol is considered a more potent pain reliever than nabumetone. Compared to nabumetone, tramadol is used to treat more severe forms of pain.

Does nabumetone cause weight gain?

Nabumetone does not normally cause weight gain as a common side effect. Weight gain from nabumetone may indicate fluid retention or a worsening of heart failure. Consult your healthcare provider immediately if you experience unusual weight gain or swelling in the hands or feet.

Nabumetone Oral Tablet 500 mg, 750 mg – Health Information Library

This medicine is used for the following purposes:

• arthritis
• gout

Brand Name(s): Relafen

Generic Name: Nabumetone

Instructions

Take the medicine with 250 mL (1 cup) of water.

Sit or stand upright for 10 minutes after taking the medicine. Do not lie down.

You may take with food to prevent stomach upset.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

This medicine can make you sensitive to the sun. Use sunscreen or protective clothing when in sun.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

It is very important that you follow your doctor’s instructions for all blood tests.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

This medicine is associated with an increased risk of serious heart problems, heart attack, and stroke. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

This medicine may cause serious bleeding from the stomach or bowels. Stop this medicine and call your doctor immediately if you see any signs of bleeding. Bleeding can cause pain in the stomach, vomiting up liquid that looks like coffee grounds, and red or dark tarry stools.

Do not use the medication any more than instructed.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Speak with your doctor before taking any medicine with aspirin.

Please check with your doctor before drinking alcohol while on this medicine.

Avoid smoking while on this medicine. Smoking may increase your risk for stroke, heart attack, blood clots, high blood pressure, and other diseases of the heart and blood vessels.

It is unknown if this medicine passes into breast milk. Ask your doctor before breastfeeding.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Do not share this medicine with anyone who has not been prescribed this medicine.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• bloating
• constipation or diarrhea
• dizziness or drowsiness
• excess gas
• headaches
• nausea and vomiting
• stomach upset or abdominal pain

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• loss of balance
• chest pain
• coughing up blood or vomit that looks like coffee grounds
• swelling of the legs, feet, and hands
• fever
• swelling in the neck or throat
• numbness or tingling in hands and feet
• signs of kidney damage (such as change in urine color or bubbly urine)
• signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
• mood changes
• ringing in the ears
• shortness of breath
• bloody or dark, tarry stools
• light colored stool
• symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
• difficulty swallowing
• blurring or changes of vision
• severe or persistent vomiting
• sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice.

There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist.

The display and use of this drug information is subject to Terms of Use.

https://api.meducation.com/V2.0/fdbpem/5049

Copyright(c) 2023 First Databank, Inc.

Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.

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Nabumetone vs Ibuprofen: Differences, Similarities & What’s Best for You – Drug Vs.

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Drug Vs. Friend

Drug Overview and Key Differences | Conditions of treatment | Efficiency | Insurance coverage and cost comparison | Side effects | Drug Interactions | Warnings | FAQ

Nabumetone and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation in arthritis. Both nabumetone and ibuprofen are generic drugs that block the release of prostaglandins, which are partly responsible for inflammation and pain in the body.

Ibuprofen may be a better known household name than nabumetone. However, both NSAIDs are effective in relieving joint pain and stiffness in patients with osteoarthritis and rheumatoid arthritis. Keep reading to learn about other important differences between these drugs.

What are the main differences between nabumetone and ibuprofen?

Nabumetone is the generic name for the discontinued Relafen. It is available by prescription and is primarily used to treat osteoarthritis and rheumatoid arthritis pain. Generic nabumetone tablets are available in 500 and 750 mg dosages. The typical dosage of nabumetone is up to 2000 mg per day, taken once or twice a day.

Ibuprofen is known under popular brand names such as Advil and Motrin. Unlike nabumetone, ibuprofen is available as a prescription or over-the-counter (OTC) pain reliever. While ibuprofen can treat arthritis pain, it is also meant to treat fever, menstrual pain, and pain from headaches or back pain. Ibuprofen is usually taken every six to eight hours depending on strength and composition.

Main differences between nabumetone and ibuprofen fen
Drug class	Non-steroidal anti-inflammatory drug (NSAID)	Non-steroidal anti-inflammatory drug (NSAID)
Brand / Generic Status	Generic available; brand name discontinued	Brands and generics available
What is a brand name?	Relafen	Advil, Motrin, Midol
What form(s) does the drug come in?	Oral tablet	Oral capsule Oral tablet Oral liquid Injection (NeoProfen)
What is the standard dosage?	1000 to 2000 mg per day, divided into one or two doses	1200 to 3200 mg per day, divided into three or four doses
How long does a typical treatment last?	The duration of treatment depends on the state of health, the severity of the pain and other factors. Treatment may be short term or long term.	The duration of treatment depends on the state of health, the severity of the pain and other factors. Treatment may be short term or long term. The over-the-counter form of ibuprofen should not be taken for longer than 10 days without consulting a doctor.
Who usually takes this medicine?	Adults	Adults and children 6 months and older

Conditions treated with nabumetone and ibuprofen

Nabumetone and ibuprofen are FDA approved for the treatment of pain and mild to moderate inflammation. osteoarthritis and rheumatoid arthritis. Osteoarthritis and rheumatoid arthritis are chronic diseases that affect the joints; however, osteoarthritis is characterized by the breakdown of cartilage around the joints over time, while rheumatoid arthritis develops when the immune system attacks the joints.

As NSAIDs, nabumetone and ibuprofen can also relieve mild to moderate pain. In particular, NSAIDs can treat headaches, musculoskeletal pain in the neck, and back pain. While ibuprofen is FDA approved for the treatment of pain, fever, and menstrual cramps (primary dysmenorrhea), nabumetone may be used as an off-label treatment.

Condition	Nabumetone	Ibuprofen
Osteoarthritis	yes	yes
Rheumatoid arthritis	yes	yes
Pain	Off label	yes
Fever	Off label	yes
Primary dysmenorrhea	Off label	yes

Is nabumetone or ibuprofen more effective?

Nabumetone and ibuprofen are effective NSAID pain relievers when used as directed. Both drugs have been approved by the FDA for the treatment of pain and inflammation in arthritis. The more effective NSAID is the one that works best for your particular condition and symptoms.

In a randomized controlled clinical trial, nabumeton was compared with other NSAIDs such as ibuprofen, naproxen and diclofenac in approximately 4000 patients with osteoarthritis or rheumatoid arthritis. After 12 weeks of treatment, researchers found that nabumetone was similar in efficacy to ibuprofen and other NSAIDs in the treatment of osteoarthritis. However, a study found that nabumetone was more effective than other NSAIDs for rheumatoid arthritis.

Nabumetone usually lasts longer than ibuprofen and other NSAIDs. It usually takes up to two weeks for nabumetone to start working for complete relief of symptoms. On the other hand, ibuprofen begins to work within 30 minutes to an hour, although it may be necessary to take it several times a day for complete relief.

Talk to your doctor about the best pain reliever for you. Your health care provider may prescribe over-the-counter or prescription medications to help relieve your pain.

Nabumetone vs. ibuprofen coverage and cost comparison

Most Medicare and insurance programs cover generic nabumetone. The copay for nabumeton will depend on the insurance plan, but can range from $0 to $57. Without insurance, the average cash price of nabumeton is about $79.99. With the Nabumeton SingleCare coupon, you will save on the price of the medicine and pay about $19.

Most insurance plans do not cover the over-the-counter version of ibuprofen. However, with a prescription, most Medicare programs and insurance plans cover ibuprofen. The average retail price of ibuprofen is about $50 for 30 prescription tablets. Using a SingleCare ibuprofen coupon card (prescription required) can help lower the cost of ibuprofen.

	Nabumetone	Ibuprofen
Usually covered by insurance?	yes	yes
Usually covered by Medicare Part D?	yes	yes
Quantity0038
Typical Medicare copay	$0-57	$0-22
SingleCare cost	$19 +	$5 +

Common side effects of nabumetone compared to ibuprofen

Nabumetone and ibuprofen may cause similar side effects. The most common side effects of these NSAIDs are gastrointestinal side effects such as indigestion, diarrhea and constipation. Compared to ibuprofen, nabumetone may be more likely to cause indigestion, abdominal pain, and diarrhea.

Other possible side effects of nabumetone and ibuprofen include nausea, dizziness, swelling of the arms or legs (oedema), headache, rash, and tinnitus.

Serious side effects of nabumetone and ibuprofen may include high blood pressure, kidney problems, heart attack, stroke, and stomach or intestinal ulcers. Allergic reactions are also possible. Seek medical attention right away if you experience severe or ongoing side effects or side effects that get worse.

	Nabumetone	Ibuprofen Side effect	Applicable?	Frequency	Applicable?	Frequency
Indigestion	yes	13%	yes	1% -3% 9 0038
Abdominal pain	yes	12%	yes	1% -3%
Diarrhea	yes	1 4%	yes	1% -3%
Nausea	yes	3% -9%	yes	1% -3%
Constipation	yes	3% -9%	yes 9 0038	1% -3%
Dizziness	yes	3% -9%	yes	1% -3%
Edema	yes	3% -9%	yes	1% -3% 900 38
Headache	yes	3% -9 %	yes	1% -3%
Rash	yes	3% -9%	yes	1% -3%
Tinnitus	yes	3% -9 %	yes	1% -3%

Frequency not based on face-to-face trial data. This may not be a complete list of side effects that may occur. Please contact your doctor or health care provider for more information.
Source: DailyMed (Nabumetone), DailyMed (Ibuprofen)

Nabumetone and ibuprofen drug interactions

NSAIDs should be used with caution with drugs such as warfarin and aspirin. Taking anticoagulants or antiplatelet drugs with NSAIDs may increase the risk of gastrointestinal bleeding and ulcers.

NSAIDs can increase blood pressure. Therefore, the effects of blood pressure lowering drugs such as lisinopril and losartan may be reduced if NSAIDs and blood pressure drugs are taken together.

Nabumetone and ibuprofen may decrease the effect of diuretics. While taking NSAIDs and diuretics, it may be necessary to monitor kidney function.

Taking nabumetone or ibuprofen with lithium or methotrexate can lead to accumulation of lithium or methotrexate in the body. This can lead to lithium or methotrexate poisoning.

This is not a complete list of possible drug interactions. Ibuprofen Nabumetone Warfarin Anticoagulant yes yes Aspirin Antiplatelet 9003 8

yes yes Lisinopril
Captopril
Ramipril Angiotensin converting enzyme (ACE) inhibitor yes yes Losartan
Valsartan
Olmesartan Angiotensin receptor blocker (ARB) yes yes Furosemide
Hydrochlorothiazide Diuretic yes yes Lithium Mood stabilizer yes yes Methotrexate

Pemetrexed

Antimetabolite yes yes

9011 8

Talk to your doctor about other possible drug interactions.

Nabumetone and ibuprofen warnings

Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of cardiovascular disease such as heart attack and stroke. People with heart disease or heart disease risk factors such as high blood pressure or high cholesterol should avoid or use NSAIDs with caution.

Medicines such as nabumetone and ibuprofen may also increase the risk of gastrointestinal events, including ulcers and intestinal bleeding. Elderly patients and patients with a history of gastric ulcers should avoid taking NSAIDs or use them with caution. The incidence of gastrointestinal bleeding may be slightly lower with nabumetone than with ibuprofen.

NSAIDs can cause fluid retention or edema, and exacerbate heart failure. Caution should be advised in patients with a history of heart failure.

Long-term use of NSAIDs can cause kidney damage over time. Talk to your doctor before using NSAIDs if you have a history of kidney problems. Before using NSAIDs such as nabumetone or ibuprofen, talk to your doctor about other possible side effects or adverse events.

Frequently asked questions about nabumetone and ibuprofen

What is nabumetone?

Nabumetone is a general NSAID analgesic or pain reliever. This is the generic name for Relafen and is only available with a prescription. Nabumetone is usually taken once or twice daily as an oral tablet to treat osteoarthritis and rheumatoid arthritis.

What is ibuprofen?

Ibuprofen acts as an NSAID to relieve pain and inflammation caused by osteoarthritis or rheumatoid arthritis. While it is available as an over-the-counter medicine to treat pain and fever, it can also be prescribed in stronger drugs to treat more severe pain. Ibuprofen is available as oral tablets, liquid solutions, capsules, and injections. Brand names for ibuprofen include Advil and Motrin.

Are nabumetone and ibuprofen the same thing?

Nabumetone and ibuprofen are not the same thing. Although they are both NSAID pain relievers, nabumetone and ibuprofen are dosed differently and can have slightly different effects. Prescription nabumetone can be taken once a day, while over-the-counter ibuprofen is usually taken several times a day. Both nabumetone and ibuprofen can treat chronic arthritis pain.

Which is better: nabumetone or ibuprofen?

Compared with placebo or no treatment, nabumetone and ibuprofen are effective in treating arthritis pain and inflammation. Nabumetone may be preferred to be taken once or twice a day. However, nabumetone can cause more stomach upset than ibuprofen and is only available by prescription. The best NSAIDs are the most economical treatment for you, as determined by your doctor.

Can I use nabumetone or ibuprofen during pregnancy?

Nabumetone and ibuprofen, like other NSAIDs, should be avoided in late pregnancy. Taking NSAIDs late in pregnancy may increase the risk of birth defects and miscarriage. Talk to your doctor before taking NSAIDs if you are breastfeeding.

Can I use nabumetone or ibuprofen with alcohol?

Moderate drinking while taking nabumetone or ibuprofen as prescribed is generally safe. Problems can begin when long-term use of NSAIDs is combined with excessive alcohol consumption. Regular alcohol consumption with NSAIDs can lead to an increased risk of stomach ulcers, kidney failure, and other side effects.

How long does it take for nabumeton to start working?

It may take one week to feel the effect of nabumetone. In some cases, it may take two weeks or more to feel maximum relief after taking nabumetone.

Is nabumetone similar to tramadol?

Nabumetone is a nonsteroidal anti-inflammatory drug and tramadol is an opioid. Tramadol is considered to be a stronger pain reliever than nabumetone. Compared to nabumetone, tramadol is used to treat more severe forms of pain.

Does nabumetone cause weight gain?

Nabumetone does not usually cause weight gain as a common side effect. Weight gain from nabumetone may indicate fluid retention or worsening heart failure. Call your doctor right away if you notice unusual weight gain or swelling in your hands or feet.

Memorial Sloan Kettering Cancer Center

Adult Medication

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This document, provided by Lexicomp ^® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Relafen DS; Relafen [DSC]

Warning

• This drug may increase the risk of heart and blood vessel problems such as myocardial infarction and stroke. These effects can be deadly. This risk may be increased if you have heart disease or risk factors for heart disease. However, the risk may be increased even for people who do not have or are at risk of developing heart disease. The risk may occur during the first weeks of using this drug and may increase with higher doses or long-term use. This drug should not be used immediately before or after coronary bypass surgery.
• This drug may increase the chance of developing severe and sometimes deadly stomach or intestinal problems, such as ulcers or bleeding. The risk is increased in the elderly and in people who have previously had ulcers or bleeding in the stomach or intestines. Such disturbances can occur suddenly.

What is this drug used for?

• Used to treat certain types of arthritis.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you are allergic to aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen.
• If you have had nasal polyps or inflammation in your mouth, face, lips, tongue, or throat, unusual hoarseness, or difficulty breathing while taking aspirin or NSAIDs.
• If you have any of the following health problems: gastrointestinal bleeding or kidney problems.
• If you have any of the following health conditions: Heart failure (weak heart) or a recent heart attack.
• If you are taking an NSAID, a salicylate such as aspirin, or pemetrexed.
• If you are unable to conceive or are testing to see if you are able to conceive.
• If you are pregnant, plan to become pregnant, or become pregnant while taking this drug. If you take this drug after 20 weeks of pregnancy, it may harm the fetus. If you are 20 to 30 weeks pregnant, take this drug only as directed by your doctor. Do not use this drug after 30 weeks of pregnancy.

This list of drugs and conditions that may interact unfavorably with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• With prolonged use of the drug, it is necessary to conduct a blood test. Talk to a medical specialist.
• The use of drugs of this kind was accompanied by high blood pressure. Monitor your blood pressure as directed by your doctor.
• Consult your doctor before drinking alcohol.
• If you smoke, please consult your doctor.
• If you have asthma, check with your doctor. You may be more sensitive to the drug.
• Do not take the drug in higher doses than prescribed by your doctor. Taking more than the prescribed amount of the drug increases the risk of serious side effects.
• Do not take this drug for longer than the length of time your doctor has prescribed.
• There is an increased chance of bleeding. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• If you are taking aspirin to prevent myocardial infarction, talk to your doctor.
• You can easily get sunburn when using this drug. Be careful if you will be in the sun. If you get sunburn easily while taking this drug, talk to your doctor.
• The risk of developing heart failure increases with the use of drugs of this kind. People with heart failure have an increased risk of myocardial infarction, hospitalization for heart failure, and death. Consult your doctor.
• The use of drugs like this has been associated with liver problems. In some cases, this has led to death. Call your doctor right away if you develop signs of liver problems such as dark urine, fatigue, lack of appetite, nausea or abdominal pain, light-colored stools, vomiting, yellowing of the skin or eyes.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• Non-steroidal anti-inflammatory drugs (NSAIDs), such as this drug, may interfere with the release of an egg (ovulation). This can negatively affect the ability to get pregnant. As a rule, the process of ovulation is restored after stopping this drug. Consult your doctor.
• Tell your doctor if you are breastfeeding. It is necessary to consult whether the drug poses any risk to the child.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
• Signs of kidney problems, including not passing urine, changes in the volume of urine, blood in the urine, or rapid weight gain.
• Signs of elevated potassium levels such as feeling of an abnormal heartbeat, confusion, feeling weak or dizzy, feeling faint, feeling numb or tingly, or short of breath.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Shortness of breath, sudden weight gain, or swelling of the arms or legs.
• Pain or pressure in the chest.
• Weakness on 1 side of the body, difficulty speaking or thinking, problems with balance, sagging on one side of the face, or blurred vision.
• Feeling extremely tired or weak.
• Tinnitus.
• Flu-like symptoms.
• Against the background of the use of this drug, severe reactions from the skin are possible. These include Stevens-Johnson syndrome (SSD), toxic epidermal necrolysis (TEN), and other serious skin reactions. Sometimes internal organs can also be affected. Such reactions can lead to death. Seek immediate medical attention if you experience skin symptoms such as redness, swelling, blisters, or peeling; with redness or irritation of the eyes; sores in the mouth, throat, nose, eyes or genitals, or any other area of ​​the skin; with high fever, chills, body pain, shortness of breath, or swollen lymph nodes.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Dizziness or headache.
• Constipation, diarrhea, abdominal pain, nausea or vomiting.
• Heartburn.
• Gas formation.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• Take with or without food. Take with food if medicine causes nausea.
• Take this drug with a full glass of water.

What should I do if I miss a dose of a drug?

• Take the missed dose as soon as you can.
• If it’s time for your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about drugs

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• A separate instruction for patients is attached to the drug. Please read this information carefully. Reread it each time you refill your supply. If you have any questions about this drug, ask your doctor, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes summaries of diagnosis, treatment and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications.